Jose L Soengas

Summary

Affiliation: University of Vigo
Country: Spain

Publications

  1. Conde Sieira M, Capelli V, Alvarez Otero R, Comesana S, Liñares Pose L, Velasco C, et al. Differential Role of Hypothalamic AMPKα Isoforms in Fish: an Evolutive Perspective. Mol Neurobiol. 2018;: pubmed publisher
    ..In contrast, the function of central AMPKα1 in fish relates to modulation of liver metabolism whereas in mammals modulates not only liver metabolism but also brown adipose tissue and thermogenesis. ..
  2. Conde Sieira M, Ceinos R, Velasco C, Comesana S, López Patiño M, Míguez J, et al. Response of rainbow trout's (Oncorhynchus mykiss) hypothalamus to glucose and oleate assessed through transcription factors BSX, ChREBP, CREB, and FoxO1. J Comp Physiol A Neuroethol Sens Neural Behav Physiol. 2018;204:893-904 pubmed publisher
    ..The results support the association of several transcription factors with metabolic control of food intake in fish. ..
  3. Librán Pérez M, Geurden I, Dias K, Corraze G, Panserat S, Soengas J. Feeding rainbow trout with a lipid-enriched diet: effects on fatty acid sensing, regulation of food intake and cellular signaling pathways. J Exp Biol. 2015;218:2610-9 pubmed publisher
    ..These proteins in the hypothalamus and liver were generally activated in fish fed the high-fat versus low-fat diet, suggesting that cellular signaling pathways are activated in response to the increased availability of fatty acids. ..
  4. Librán Pérez M, Velasco C, Otero Rodiño C, López Patiño M, Míguez J, Soengas J. Effects of insulin treatment on the response to oleate and octanoate of food intake and fatty acid-sensing systems in rainbow trout. Domest Anim Endocrinol. 2015;53:124-35 pubmed publisher
    ..Therefore, we provide for the first time in fish, and in a non-mammalian vertebrate, evidence for the modulation of FA-sensing systems by insulin. ..
  5. Otero Rodiño C, Librán Pérez M, Velasco C, Álvarez Otero R, López Patiño M, Míguez J, et al. Glucosensing in liver and Brockmann bodies of rainbow trout through glucokinase-independent mechanisms. Comp Biochem Physiol B Biochem Mol Biol. 2016;199:29-42 pubmed publisher
    ..The stress conditions elicited by HSD altered the response of the glucosensor systems based on mitochondrial activity, sweet taste receptor, and SGLT-1 in the liver, and LXR and SGLT-1 in the BB. ..
  6. Conde Sieira M, Bonacic K, Velasco C, Valente L, Morais S, Soengas J. Hypothalamic fatty acid sensing in Senegalese sole (Solea senegalensis): response to long-chain saturated, monounsaturated, and polyunsaturated (n-3) fatty acids. Am J Physiol Regul Integr Comp Physiol. 2015;309:R1521-31 pubmed publisher
    ..Both OA and ALA enhanced anorexigenic capacity compatible with the activation of FA sensing systems. ..
  7. Otero Rodiño C, Librán Pérez M, Velasco C, Álvarez Otero R, López Patiño M, Míguez J, et al. Response of lactate metabolism in brain glucosensing areas of rainbow trout (Oncorhynchus mykiss) to changes in glucose levels. J Comp Physiol B. 2015;185:869-82 pubmed publisher
  8. Velasco C, Comesana S, Conde Sieira M, Míguez J, Soengas J. The short-term presence of oleate or octanoate alters the phosphorylation status of Akt, AMPK, mTOR, CREB, and FoxO1 in liver of rainbow trout (Oncorhynchus mykiss). Comp Biochem Physiol B Biochem Mol Biol. 2018;219-220:17-25 pubmed publisher
  9. Soengas J. Contribution of glucose- and fatty acid sensing systems to the regulation of food intake in fish. A review. Gen Comp Endocrinol. 2014;205:36-48 pubmed publisher
    ..The present review will provide a picture of the main results obtained to date in these studies, as well as perspectives for future research in the field. ..

More Information

Publications22

  1. Otero Rodiño C, Velasco C, Alvarez Otero R, López Patiño M, Míguez J, Soengas J. In vitro evidence in rainbow trout supporting glucosensing mediated by sweet taste receptor, LXR, and mitochondrial activity in Brockmann bodies, and sweet taste receptor in liver. Comp Biochem Physiol B Biochem Mol Biol. 2016;200:6-16 pubmed publisher
  2. Velasco C, Moreiras G, Conde Sieira M, Leao J, Míguez J, Soengas J. Ceramide counteracts the effects of ghrelin on the metabolic control of food intake in rainbow trout. J Exp Biol. 2017;220:2563-2576 pubmed publisher
    ..The results are discussed in the context of regulation of food intake by metabolic and endocrine inputs. ..
  3. Velasco C, Librán Pérez M, Otero Rodiño C, López Patiño M, Míguez J, Soengas J. Intracerebroventricular ghrelin treatment affects lipid metabolism in liver of rainbow trout (Oncorhynchus mykiss). Gen Comp Endocrinol. 2016;228:33-39 pubmed publisher
    ..These results give support to the notion of hypothalamus as an integrative place for the regulation of peripheral energy metabolism in fish. ..
  4. Velasco C, Librán Pérez M, Otero Rodiño C, López Patiño M, Míguez J, Soengas J. Ceramides are involved in the regulation of food intake in rainbow trout (Oncorhynchus mykiss). Am J Physiol Regul Integr Comp Physiol. 2016;311:R658-R668 pubmed publisher
    ..The results suggest that ceramides are involved in the regulation of food intake in rainbow trout through mechanisms comparable to those characterized previously in mammals in some cases. ..
  5. Soengas J, Cerdá Reverter J, Delgado M. Central regulation of food intake in fish: an evolutionary perspective. J Mol Endocrinol. 2018;60:R171-R199 pubmed publisher
  6. Marandel L, Panserat S, Plagnes Juan E, Arbenoits E, Soengas J, Bobe J. Evolutionary history of glucose-6-phosphatase encoding genes in vertebrate lineages: towards a better understanding of the functions of multiple duplicates. BMC Genomics. 2017;18:342 pubmed publisher
    ..Our results suggested that the fixation and the divergence of g6pc duplicated genes during vertebrates' evolution may lead to adaptive novelty and probably to the emergence of novel phenotypes related to glucose homeostasis. ..
  7. Otero Rodiño C, Velasco C, Alvarez Otero R, López Patiño M, Míguez J, Soengas J. In vitro evidence supports the presence of glucokinase-independent glucosensing mechanisms in hypothalamus and hindbrain of rainbow trout. J Exp Biol. 2016;219:1750-9 pubmed publisher
    ..The response observed in the presence of these specific inhibitors/antagonists further supports the proposal that critical components of the different glucosensing mechanisms are functioning in rainbow trout hypothalamus and hindbrain. ..
  8. request reprint
    Gómez Boronat M, Velasco C, Isorna E, de Pedro N, Delgado M, Soengas J. The satiety factor oleoylethanolamide impacts hepatic lipid and glucose metabolism in goldfish. J Comp Physiol B. 2016;186:1009-1021 pubmed
    ..These results support an important role for OEA in the regulation of liver lipid and glucose metabolism, and could relate to the metabolic changes associated with circadian activity and the regulation of food intake in fish. ..
  9. Velasco C, Otero Rodiño C, Comesana S, Míguez J, Soengas J. Hypothalamic mechanisms linking fatty acid sensing and food intake regulation in rainbow trout. J Mol Endocrinol. 2017;59:377-390 pubmed publisher
    ..The results support, for the first time in fish, the involvement of these proteins in the regulation of food intake by fatty acids. ..
  10. Otero Rodiño C, Velasco C, Alvarez Otero R, López Patiño M, Míguez J, Soengas J. Changes in the levels and phosphorylation status of Akt, AMPK, CREB and FoxO1 in hypothalamus of rainbow trout under conditions of enhanced glucosensing activity. J Exp Biol. 2017;220:4410-4417 pubmed publisher
  11. Comesana S, Velasco C, Ceinos R, López Patiño M, Míguez J, Morais S, et al. Evidence for the presence in rainbow trout brain of amino acid sensing systems involved in the control of food intake. Am J Physiol Regul Integr Comp Physiol. 2017;:ajpregu.00283.2017 pubmed publisher
    ..Another novel result is the clear effect of leucine on telencephalon, in which amino acid sensing systems, but not neuropeptides, were activated as in hypothalamus...
  12. Velasco C, Librán Pérez M, Otero Rodiño C, López Patiño M, Míguez J, Cerdá Reverter J, et al. Ghrelin modulates hypothalamic fatty acid-sensing and control of food intake in rainbow trout. J Endocrinol. 2016;228:25-37 pubmed publisher
    ..These changes provide evidence for the first time in fish of a possible modulatory role of ghrelin on the metabolic regulation by fatty acid of food intake occurring in the hypothalamus. ..
  13. Soengas J, Polakof S, Chen X, Sangiao Alvarellos S, Moon T. Glucokinase and hexokinase expression and activities in rainbow trout tissues: changes with food deprivation and refeeding. Am J Physiol Regul Integr Comp Physiol. 2006;291:R810-21 pubmed publisher