Carmen Sanmartin

Summary

Affiliation: University of Navarra
Country: Spain

Publications

  1. ncbi request reprint Selenium compounds and apoptotic modulation: a new perspective in cancer therapy
    Carmen Sanmartin
    Department of Organic and Pharmaceutical Chemistry, Faculty of Pharmacy, University of Navarra, Irunlarrea 1, E 31008, Pamplona, Spain
    Mini Rev Med Chem 8:1020-31. 2008
  2. ncbi request reprint Innovative lead compounds and formulation strategies as newer kinetoplastid therapies
    S Espuelas
    Department of Pharmacy and Pharmaceutical Technology, Faculty of Pharmacy, University of Navarra, Irunlarrea 1, E 31008, Pamplona, Spain
    Curr Med Chem 19:4259-88. 2012
  3. ncbi request reprint The quinoline imidoselenocarbamate EI201 blocks the AKT/mTOR pathway and targets cancer stem cells leading to a strong antitumor activity
    E Ibanez
    Synthesis Section, Department of Organic and Pharmaceutical Chemistry, University of Navarra, Irunlarrea, 1, E 31008 Pamplona, Spain
    Curr Med Chem 19:3031-43. 2012
  4. ncbi request reprint Kinase regulation by sulfur and selenium containing compounds
    Carmen Sanmartin
    Department of Organic and Pharmaceutical Chemistry, University of Navarra, Irunlarrea 1, E 31008, Pamplona, Spain
    Curr Cancer Drug Targets 11:496-523. 2011
  5. ncbi request reprint Selenium and clinical trials: new therapeutic evidence for multiple diseases
    C Sanmartin
    Department of Organic and Pharmaceutical Chemistry, University of Navarra, Irunlarrea, Pamplona, Spain
    Curr Med Chem 18:4635-50. 2011
  6. ncbi request reprint Molecular symmetry: a structural property frequently present in new cytotoxic and proapoptotic drugs
    Carmen Sanmartin
    Department of Organic and Pharmaceutical Chemistry, University of Navarra, Irunlarrea 1, E 31008 Pamplona, Spain
    Mini Rev Med Chem 6:639-50. 2006
  7. doi request reprint Synthesis and pharmacological screening of several aroyl and heteroaroyl selenylacetic acid derivatives as cytotoxic and antiproliferative agents
    Carmen Sanmartin
    Synthesis Section, Department of Organic and Pharmaceutical Chemistry, University of Navarra, Irunlarrea, 1, E 31008 Pamplona, Spain
    Molecules 14:3313-38. 2009
  8. ncbi request reprint Synthesis and biological evaluation of heteroaryldiamides and heteroaryldiamines as cytotoxic agents, apoptosis inducers and caspase-3 activators
    Mikel Echeverria
    Sección de Síntesis, Departamento de Quimica Organica y Farmaceutica, University of Navarra, Pamplona, Spain
    Arch Pharm (Weinheim) 339:182-92. 2006
  9. ncbi request reprint Synthesis and biological evaluation of new symmetrical derivatives as cytotoxic agents and apoptosis inducers
    Carmen Sanmartin
    Sección de Síntesis, Departamento de Quimica Organica y Farmaceutica, Universidad de Navarra, Irunlarrea, 1, E 31008 Pamplona, Spain
    Bioorg Med Chem 13:2031-44. 2005
  10. ncbi request reprint Bisacylimidoselenocarbamates cause G2/M arrest associated with the modulation of CDK1 and Chk2 in human breast cancer MCF-7 cells
    Iranzu Lamberto
    Department of Organic and Pharmaceutical Chemistry, University of Navarra, Irunlarrea, 1, E 31008 Pamplona, Spain
    Curr Med Chem 20:1609-19. 2013

Collaborators

Detail Information

Publications33

  1. ncbi request reprint Selenium compounds and apoptotic modulation: a new perspective in cancer therapy
    Carmen Sanmartin
    Department of Organic and Pharmaceutical Chemistry, Faculty of Pharmacy, University of Navarra, Irunlarrea 1, E 31008, Pamplona, Spain
    Mini Rev Med Chem 8:1020-31. 2008
    ..The aim of this review is to summarize the current knowledge about more than twenty eight selenium-containing molecules and to discuss the implications for apoptosis and the impact in cancer therapy...
  2. ncbi request reprint Innovative lead compounds and formulation strategies as newer kinetoplastid therapies
    S Espuelas
    Department of Pharmacy and Pharmaceutical Technology, Faculty of Pharmacy, University of Navarra, Irunlarrea 1, E 31008, Pamplona, Spain
    Curr Med Chem 19:4259-88. 2012
    ..Bioadhesive nanoparticles can be proposed to enhance the bioavailability of drugs after oral administration by reason of improving the drug solubility, and permeability across the intestinal epithelia...
  3. ncbi request reprint The quinoline imidoselenocarbamate EI201 blocks the AKT/mTOR pathway and targets cancer stem cells leading to a strong antitumor activity
    E Ibanez
    Synthesis Section, Department of Organic and Pharmaceutical Chemistry, University of Navarra, Irunlarrea, 1, E 31008 Pamplona, Spain
    Curr Med Chem 19:3031-43. 2012
    ..Taken together, our results support further development of EI201 as a novel multi-kinase inhibitor that may be useful against cancers with aberrant upregulation of PI3K/AKT and MAPK signaling pathways...
  4. ncbi request reprint Kinase regulation by sulfur and selenium containing compounds
    Carmen Sanmartin
    Department of Organic and Pharmaceutical Chemistry, University of Navarra, Irunlarrea 1, E 31008, Pamplona, Spain
    Curr Cancer Drug Targets 11:496-523. 2011
    ....
  5. ncbi request reprint Selenium and clinical trials: new therapeutic evidence for multiple diseases
    C Sanmartin
    Department of Organic and Pharmaceutical Chemistry, University of Navarra, Irunlarrea, Pamplona, Spain
    Curr Med Chem 18:4635-50. 2011
    ..Based on these studies this review focuses on the advances made so far in the study of mechanisms and applications of selenium compounds that could be suitable for chronic diseases...
  6. ncbi request reprint Molecular symmetry: a structural property frequently present in new cytotoxic and proapoptotic drugs
    Carmen Sanmartin
    Department of Organic and Pharmaceutical Chemistry, University of Navarra, Irunlarrea 1, E 31008 Pamplona, Spain
    Mini Rev Med Chem 6:639-50. 2006
    ..The present review highlights the importance of the molecular symmetry of several chemical structures and their relation with cytotoxic and apoptotic activity...
  7. doi request reprint Synthesis and pharmacological screening of several aroyl and heteroaroyl selenylacetic acid derivatives as cytotoxic and antiproliferative agents
    Carmen Sanmartin
    Synthesis Section, Department of Organic and Pharmaceutical Chemistry, University of Navarra, Irunlarrea, 1, E 31008 Pamplona, Spain
    Molecules 14:3313-38. 2009
    ..69, 4.18 and 6.19 microM. On the other hand, in PC-3 these compounds showed values of 6.8, 4.0 and 2.9 microM. Furthermore, benzoylselenylacetic acid did not provoke apoptosis nor did it perturb the cell cycle in MCF-7...
  8. ncbi request reprint Synthesis and biological evaluation of heteroaryldiamides and heteroaryldiamines as cytotoxic agents, apoptosis inducers and caspase-3 activators
    Mikel Echeverria
    Sección de Síntesis, Departamento de Quimica Organica y Farmaceutica, University of Navarra, Pamplona, Spain
    Arch Pharm (Weinheim) 339:182-92. 2006
    ..The different types of behaviour of each compound are not necessarily parallel in the three cell lines tested...
  9. ncbi request reprint Synthesis and biological evaluation of new symmetrical derivatives as cytotoxic agents and apoptosis inducers
    Carmen Sanmartin
    Sección de Síntesis, Departamento de Quimica Organica y Farmaceutica, Universidad de Navarra, Irunlarrea, 1, E 31008 Pamplona, Spain
    Bioorg Med Chem 13:2031-44. 2005
    ..Subsequent modulation of these lead structures permits advances in the design of potent cytotoxic and proapoptotic anticancer drugs...
  10. ncbi request reprint Bisacylimidoselenocarbamates cause G2/M arrest associated with the modulation of CDK1 and Chk2 in human breast cancer MCF-7 cells
    Iranzu Lamberto
    Department of Organic and Pharmaceutical Chemistry, University of Navarra, Irunlarrea, 1, E 31008 Pamplona, Spain
    Curr Med Chem 20:1609-19. 2013
    ..Moreover, since reduced levels of p21(CIP1) and Chk2 proteins but no change in p53 levels could be detected in MCF-7 cells after BSC 3g or 3n treatment our results suggest that BSC treated cells die from lethal mitosis...
  11. doi request reprint Sulfur and selenium derivatives of quinazoline and pyrido[2,3-d]pyrimidine: synthesis and study of their potential cytotoxic activity in vitro
    Esther Moreno
    Sección de Síntesis, Departamento de Quimica Organica y Farmaceutica, University of Navarra, Irunlarrea, 1, E 31008 Pamplona, Spain
    Eur J Med Chem 47:283-98. 2012
    ..A preliminary study into the mechanism of the potent derivatives 2o, 3a and 7h indicated that the cytotoxic activities of these compounds might be mediated by inducing cell death without affecting cell cycle phases...
  12. doi request reprint Structural characteristics of phosphoramide derivatives as urease inhibitors. Requirements for activity
    Maria Font
    Molecular Modeling Section, Department of Organic and Pharmaceutical Chemistry, University of Navarra, Irunlarrea 1, E 31008 Pamplona, Spain
    J Agric Food Chem 56:8451-60. 2008
    ..These data, along with the preliminary docking study carried out, allow us to propose a union mode to the active site of the enzyme for these compounds...
  13. doi request reprint Synthesis and in vitro anticancer activities of some selenadiazole derivatives
    Daniel Plano
    Departamento de Quimica Organica y Farmaceutica, University of Navarra, Pamplona, Spain
    Arch Pharm (Weinheim) 343:680-91. 2010
    ..Compound 2a also provoked cell cycle arrest with a significant decrease in the G₀/G₁ phase cell population and an increase in S and G₂/M cells, thus suggesting mitotic arrest prior to metaphase...
  14. doi request reprint Structural variations on antitumour agents derived from bisacylimidoselenocarbamate. A proposal for structure-activity relationships based on the analysis of conformational behaviour
    Maria Font
    Sección de Modelización Molecular, Facultad de Farmacia, Departamento de Quimica Organica y Farmaceutica, Universidad de Navarra, Irunlarrea, 1, E 31008 Pamplona, Spain
    Eur J Med Chem 66:489-98. 2013
    ....
  15. ncbi request reprint Synthesis and biological evaluation of 2,4,6-functionalized derivatives of pyrido[2,3-d]pyrimidines as cytotoxic agents and apoptosis inducers
    Carmen Sanmartin
    Sección de Síntesis, Departamento de Quimica Organica y Farmaceutica, University of Navarra, Pamplona, Spain
    Arch Pharm (Weinheim) 341:28-41. 2008
    ..In order to test the selectivity of the compounds, two non-tumoral human cell lines were used. Several compounds of the did not show cytotoxicity in these cell lines...
  16. doi request reprint Synthesis and antiproliferative activity of novel symmetrical alkylthio- and alkylseleno-imidocarbamates
    Elena Ibáñez
    Synthesis Section, Department of Organic and Pharmaceutical Chemistry, University of Navarra, Irunlarrea, 1, E 31008 Pamplona, Spain
    Eur J Med Chem 46:265-74. 2011
    ..These two compounds can therefore be considered as the most promising candidates for the development of novel generations of antitumor agents...
  17. ncbi request reprint New symmetrical quinazoline derivatives selectively induce apoptosis in human cancer cells
    Elena Cubedo
    Laboratorio de Farmacogenómica, Area de Oncología, Centro de Investigación Médica Aplicada, Pamplona, Spain
    Cancer Biol Ther 5:850-9. 2006
    ..In conclusion, 2,4-dibenzylaminoquinazoline is a promising anticancer drug showing cytostatic and apoptotic effects mainly in a transcription independent manner...
  18. ncbi request reprint Novel potent organoselenium compounds as cytotoxic agents in prostate cancer cells
    Daniel Plano
    Sección de Síntesis, Departamento de Quimica Organica y Farmaceutica, University of Navarra, Irunlarrea, 1, E 31008 Pamplona, Spain
    Bioorg Med Chem Lett 17:6853-9. 2007
    ..Five compounds showed interesting activity levels and 3p (IC(50)=1.85 microM) was 7.3 times more active than the standard etoposide used in the treatment of prostate cancer and emerges as the most interesting compound...
  19. doi request reprint Antioxidant-prooxidant properties of a new organoselenium compound library
    Daniel Plano
    Department of Organic and Pharmaceutical Chemistry, University of Navarra, Irunlarrea, 1, E 31008 Pamplona, Spain
    Molecules 15:7292-312. 2010
    ....
  20. doi request reprint Novel structural insights for imidoselenocarbamates with antitumoral activity related to their ability to generate methylselenol
    Maria Font
    Sección de Modelización Molecular, Departamento de Quimica Organica y Farmaceutica, University of Navarra, Irunlarrea 1, E 31008 Pamplona, Spain
    Bioorg Med Chem 20:5110-6. 2012
    ..This activity is related to the controlled delivery of methylselenol and makes this an interesting approach to develop new antitumoral agents...
  21. doi request reprint Novel library of selenocompounds as kinase modulators
    Daniel Plano
    Department of Organic and Pharmaceutical Chemistry, University of Navarra, Irunlarrea, Pamplona E 31008, Spain
    Molecules 16:6349-64. 2011
    ..In conclusion, we propose that the replacement of sulfur by selenium seems to be a potential and useful strategy in the search of novel chemical compound libraries against cancer as kinase modulators...
  22. doi request reprint Selenocyanates and diselenides: a new class of potent antileishmanial agents
    Daniel Plano
    Sección de Síntesis, Departamento de Quimica Organica y Farmaceutica, University of Navarra, Irunlarrea, 1, E 31008 Pamplona, Spain
    Eur J Med Chem 46:3315-23. 2011
    ..This compound thus represents a new lead for further studies aimed at establishing its mechanism of action...
  23. ncbi request reprint Biological profile of new apoptotic agents based on 2,4-pyrido[2,3-d]pyrimidine derivatives
    Lucia Cordeu
    Laboratorio de Farmacogenómica, Area de Oncología, Centro de Investigación Médica Aplicada, Pamplona, Spain
    Bioorg Med Chem 15:1659-69. 2007
    ....
  24. doi request reprint Novel hybrid selenosulfonamides as potent antileishmanial agents
    Ylenia Baquedano
    Departamento de Quimica Organica y Farmaceutica, University of Navarra, Irunlarrea, 1, E 31008 Pamplona, Spain Instituto de Salud Tropical, University of Navarra, Irunlarrea, 1, E 31008 Pamplona, Spain
    Eur J Med Chem 74:116-23. 2014
    ..These compounds could potentially serve as templates for future drug-optimization and drug-development efforts for their use as therapeutic agents in developing countries...
  25. doi request reprint Structure- and cell-specific effects of imidoselenocarbamates on selenoprotein expression and activity in liver cells in culture
    Elena Ibáñez
    Synthesis Section, Department of Organic and Pharmaceutical Chemistry, University of Navarra, Irunlarrea, 1, E 31008 Pamplona, Spain
    Metallomics 4:1297-307. 2012
    ..These effects represent a promising finding with respect to the identification of therapeutic selenocompounds, as cancer-cell specificity is combined with desired effects on selenoprotein expression and activity...
  26. doi request reprint New insights into the structural requirements for pro-apoptotic agents based on 2,4-diaminoquinazoline, 2,4-diaminopyrido[2,3-d]pyrimidine and 2,4-diaminopyrimidine derivatives
    Maria Font
    Sección de Modelización Molecular, Dpto de Química Orgánica y Farmacéutica, Facultad de Farmacia, Universidad de Navarra, Irunlarrea 1, E 31008 Pamplona, Spain
    Eur J Med Chem 46:3887-99. 2011
    ....
  27. ncbi request reprint Nanoparticles as multifunctional devices for the topical treatment of cutaneous leishmaniasis
    Esther Moreno
    University of Navarra, Tropical Health Institute, Irunlarrea, 1 E 31008 Pamplona, Spain 34948425600 34948425619
    Expert Opin Drug Deliv 11:579-97. 2014
    ..It is also recommended in combination with systemic therapy for more severe forms. Progresses in this modality of treatment are hindered by the heterogeneity of the disease and shortcomings in the clinical trials...
  28. ncbi request reprint Synthesis and antiproliferative activity of novel selenoester derivatives
    Enrique Domínguez-Álvarez
    Synthesis Section, Department of Organic and Pharmaceutical Chemistry, University of Navarra, Irunlarrea 1, E 31008 Pamplona, Spain Division of Bioorganic Chemistry, School of Pharmacy, Saarland University, Campus, 66123 Saarbruecken, Germany
    Eur J Med Chem 73:153-66. 2014
    ..The present results revealed that analogues 5, 21, 28 and 30 might serve as a useful starting point for the design of improved anti-tumour agents. ..
  29. ncbi request reprint Structural characteristics of novel symmetrical diaryl derivatives with nitrogenated functions. Requirements for cytotoxic activity
    Maria Font
    Sección de Modelización Molecular, Departamento de Quimica Organica y Farmaceutica, University of Navarra, Pamplona, Spain
    Bioorg Med Chem 14:1942-8. 2006
    ....
  30. ncbi request reprint Design, synthesis, and biological evaluation of phosphoramide derivatives as urease inhibitors
    María J Domínguez
    Synthesis Section and Molecular Modeling Section, Department of Organic and Pharmaceutical Chemistry, University of Navarra, Irunlarrea 1, E 31008 Pamplona, Spain
    J Agric Food Chem 56:3721-31. 2008
    ..On the basis of the activity results and the conclusions of the molecular modeling study, a structural model for new potential inhibitors has been defined...
  31. ncbi request reprint A new polyamine derivative, a structural analog of spermine, with in vivo activity as an inhibitor of ethanol appetite
    Maria Font
    Modelización Molecular, Departamento de Quimica Organica y Farmaceutica, Universidad de Navarra, Irunlarrea No 1, E 31008 Pamplona, Spain
    Bioorg Med Chem 13:4375-82. 2005
    ..These polyamines have shown activity as inhibitors of ethanol appetite in the same experimental model...
  32. doi request reprint Thermosensitive hydrogels of poly(methyl vinyl ether-co-maleic anhydride) - Pluronic(®) F127 copolymers for controlled protein release
    Esther Moreno
    Tropical Health Institute, University of Navarra, Irunlarrea 1, E 31008 Pamplona, Spain
    Int J Pharm 459:1-9. 2014
    ....
  33. pmc Selenium compounds, apoptosis and other types of cell death: an overview for cancer therapy
    Carmen Sanmartin
    Department of Organic and Pharmaceutical Chemistry, University of Navarra, Irunlarrea 1, Pamplona E 31008, Spain E Mails D P J A P
    Int J Mol Sci 13:9649-72. 2012
    ..Emerging evidence indicates the overlaps between the apoptosis and other types of cell death such as autophagy. In this review we report different processes of cell death induced by Se compounds in cancer treatment and prevention...