M J Ruiz

Summary

Affiliation: University of Valencia
Country: Spain

Publications

  1. ncbi Genotoxicity of six pesticides by Salmonella mutagenicity test and SOS chromotest
    M J Ruiz
    Laboratori de Toxicologia, Facultat de Formàcia, Universitat de Valencia, Spain
    Mutat Res 390:245-55. 1997
  2. doi Dietary administration of high doses of pterostilbene and quercetin to mice is not toxic
    M J Ruiz
    Departamento de Fisiologia, Facultat de Farmacia, Universitat de Valencia, Valencia, Spain
    J Agric Food Chem 57:3180-6. 2009
  3. doi Cytotoxic effects of mycotoxin combinations in mammalian kidney cells
    Maria Jose Ruiz
    Laboratori de Toxicologia, Facultat de Farmacia, Universitat de Valencia, Av Vicent Andres Estelles, 46100 Burjassot, Valencia, Spain
    Food Chem Toxicol 49:2718-24. 2011
  4. doi Toxicological interactions between the mycotoxins beauvericin, deoxynivalenol and T-2 toxin in CHO-K1 cells in vitro
    M J Ruiz
    Laboratori de Toxicologia, Facultat de Farmacia, Universitat de Valencia, Av Vicent Andres Estelles, 46100 Burjassot, Valencia, Spain
    Toxicon 58:315-26. 2011
  5. doi Beauvericin-induced cytotoxicity via ROS production and mitochondrial damage in Caco-2 cells
    A Prosperini
    Laboratory of Food Chemistry and Toxicology, Faculty of Pharmacy, University of Valencia, Av Vicent Andres Estelles s n, 46100 Burjassot, Valencia, Spain Electronic address
    Toxicol Lett 222:204-11. 2013
  6. doi Reactive oxygen species involvement in apoptosis and mitochondrial damage in Caco-2 cells induced by enniatins A, A₁, B and B₁
    A Prosperini
    Laboratori de Toxicologia, Facultat de Farmacia, Universitat de Valencia, Av Vincent Andres Estelles, 46100 Burjassot, Valencia, Spain
    Toxicol Lett 222:36-44. 2013
  7. doi Toxicity evaluation of individual and mixed enniatins using an in vitro method with CHO-K1 cells
    H Lu
    Laboratorio de Toxicologia, Facultat de Farmacia, Universitat de Valencia, Av Vicent Andres Estelles, S N, 46117 Burjassot, Valencia, Spain
    Toxicol In Vitro 27:672-80. 2013
  8. ncbi Disturbance of antioxidant capacity produced by beauvericin in CHO-K1 cells
    B Mallebrera
    Laboratory of Toxicology, Faculty of Pharmacy, University of Valencia, Av Vicent Andres Estelles s n, 46100 Burjassot, Valencia, Spain Electronic address
    Toxicol Lett 226:337-42. 2014
  9. doi Study of the potential toxicity of enniatins A, A(1), B, B(1) by evaluation of duodenal and colonic bioavailability applying an in vitro method by Caco-2 cells
    G Meca
    Laboratory of Food Chemistry and Toxicology, Faculty of Pharmacy, University of Valencia, Avenue Vicent Andres Estelles s n, 46100 Burjassot, Valencia, Spain
    Toxicon 59:1-11. 2012
  10. doi Co-occurrence and risk assessment of mycotoxins in food and diet from Mediterranean area
    A B Serrano
    Laboratory of Food Chemistry and Toxicology, Faculty of Pharmacy, University of Valencia, Avenue Vicent Andres Estelles s n, 46100 Burjassot, Spain
    Food Chem 135:423-9. 2012

Collaborators

Detail Information

Publications15

  1. ncbi Genotoxicity of six pesticides by Salmonella mutagenicity test and SOS chromotest
    M J Ruiz
    Laboratori de Toxicologia, Facultat de Formàcia, Universitat de Valencia, Spain
    Mutat Res 390:245-55. 1997
    ....
  2. doi Dietary administration of high doses of pterostilbene and quercetin to mice is not toxic
    M J Ruiz
    Departamento de Fisiologia, Facultat de Farmacia, Universitat de Valencia, Valencia, Spain
    J Agric Food Chem 57:3180-6. 2009
    ..Biochemical parameters were not affected. Histopathological examination revealed no alterations in clinical signs or organ weight at any dose...
  3. doi Cytotoxic effects of mycotoxin combinations in mammalian kidney cells
    Maria Jose Ruiz
    Laboratori de Toxicologia, Facultat de Farmacia, Universitat de Valencia, Av Vicent Andres Estelles, 46100 Burjassot, Valencia, Spain
    Food Chem Toxicol 49:2718-24. 2011
    ..43-5.89), DON+T-2 toxin (3.13-7.62) and BEA+DON+T-2 toxin (1.32-2.68) for 24, 48 and 72h produced antagonistic effects in Vero cells. The highest antagonistic effect in Vero cells was observed with binary DON and T-2 toxin mixture...
  4. doi Toxicological interactions between the mycotoxins beauvericin, deoxynivalenol and T-2 toxin in CHO-K1 cells in vitro
    M J Ruiz
    Laboratori de Toxicologia, Facultat de Farmacia, Universitat de Valencia, Av Vicent Andres Estelles, 46100 Burjassot, Valencia, Spain
    Toxicon 58:315-26. 2011
    ....
  5. doi Beauvericin-induced cytotoxicity via ROS production and mitochondrial damage in Caco-2 cells
    A Prosperini
    Laboratory of Food Chemistry and Toxicology, Faculty of Pharmacy, University of Valencia, Av Vicent Andres Estelles s n, 46100 Burjassot, Valencia, Spain Electronic address
    Toxicol Lett 222:204-11. 2013
    ..0 μM concentration. This study demonstrated that oxidative stress is one of the mechanism involved in BEA toxicity, moreover apoptosis induction and loss of ΔΨm contribute to its cytotoxicity in Caco-2 cells...
  6. doi Reactive oxygen species involvement in apoptosis and mitochondrial damage in Caco-2 cells induced by enniatins A, A₁, B and B₁
    A Prosperini
    Laboratori de Toxicologia, Facultat de Farmacia, Universitat de Valencia, Av Vincent Andres Estelles, 46100 Burjassot, Valencia, Spain
    Toxicol Lett 222:36-44. 2013
    ..ENs A, A₁ and B₁ induced DNA damage. However the same effects cannot be proposed for EN B. Further studies on the toxicological effects induced by ENs A, A₁, B and B₁ are needed...
  7. doi Toxicity evaluation of individual and mixed enniatins using an in vitro method with CHO-K1 cells
    H Lu
    Laboratorio de Toxicologia, Facultat de Farmacia, Universitat de Valencia, Av Vicent Andres Estelles, S N, 46117 Burjassot, Valencia, Spain
    Toxicol In Vitro 27:672-80. 2013
    ..67±1.32) and ENs A1+B+B1 (CI=3.14±1.91). These results provide quantitative evidence that ENs cytotoxicity depend on their concentrations, and also on their combination with other mycotoxins...
  8. ncbi Disturbance of antioxidant capacity produced by beauvericin in CHO-K1 cells
    B Mallebrera
    Laboratory of Toxicology, Faculty of Pharmacy, University of Valencia, Av Vicent Andres Estelles s n, 46100 Burjassot, Valencia, Spain Electronic address
    Toxicol Lett 226:337-42. 2014
    ..In addition, NAC is an effective scavenger of BEA. GSH and related enzymes play an antioxidant role in the defense system of CHO-K1 cells exposed to BEA...
  9. doi Study of the potential toxicity of enniatins A, A(1), B, B(1) by evaluation of duodenal and colonic bioavailability applying an in vitro method by Caco-2 cells
    G Meca
    Laboratory of Food Chemistry and Toxicology, Faculty of Pharmacy, University of Valencia, Avenue Vicent Andres Estelles s n, 46100 Burjassot, Valencia, Spain
    Toxicon 59:1-11. 2012
    ..3% for EN A, from 40.8 to 50.0% for EN A(1), from 47.7 to 55.0% for EN B, and from 52.4 to 57.4% for En B(1). The highest duodenal and colonic bioavailability was observed after Caco-2 cells exposed to EN A, ENs B and B(1), respectively...
  10. doi Co-occurrence and risk assessment of mycotoxins in food and diet from Mediterranean area
    A B Serrano
    Laboratory of Food Chemistry and Toxicology, Faculty of Pharmacy, University of Valencia, Avenue Vicent Andres Estelles s n, 46100 Burjassot, Spain
    Food Chem 135:423-9. 2012
    ....
  11. doi Study of the cytotoxic activity of beauvericin and fusaproliferin and bioavailability in vitro on Caco-2 cells
    A Prosperini
    Laboratory of Food Chemistry and Toxicology, Faculty of Pharmacy, University of Valencia, Av Vicent Andres Estelles s n, 46100 Burjassot, Spain
    Food Chem Toxicol 50:2356-61. 2012
    ..BEA bioavailability was variable from 50.1% to 54.3%, whereas FUS presented a bioavailability variable from 80.2% to 83.2%. Results obtained demonstrated a potential risk for human health...
  12. doi Comparative cytotoxicity study of enniatins A, A₁, A₂, B, B₁, B₄ and J₃ on Caco-2 cells, Hep-G₂ and HT-29
    G Meca
    Laboratory of Food Chemistry and Toxicology, Faculty of Pharmacy, University of Valencia, Av Vicent Andres Estelles s n, 46100 Burjassot, Spain
    Food Chem Toxicol 49:2464-9. 2011
    ..7 ± 0.7 to 11.5 ± 5.3 μM) and B(4) (IC(50) of 4.5 ± 2.9-15.0 ± 4.0 μM). In summary, this study demonstrated that ENs can exert toxic activity at low micromolar concentrations in mammalian cells...
  13. doi Reactive oxygen species induced by beauvericin, patulin and zearalenone in CHO-K1 cells
    E Ferrer
    Laboratori de Toxicologia, Facultat de Farmacia, Universitat de Valencia, Av Vicent Andres Estelles, 46100 Burjassot, Valencia, Spain
    Toxicol In Vitro 23:1504-9. 2009
    ..These data suggested that cytotoxicity and ROS generation are mechanisms of mycotoxins mediated toxicity...
  14. doi Isolation and purification of enniatins A, A(1), B, B(1), produced by Fusarium tricinctum in solid culture, and cytotoxicity effects on Caco-2 cells
    G Meca
    Laboratory of Food Chemistry and Toxicology, Faculty of Pharmacy, University of Valencia, Avenue Vicent Andres Estelles s n, 46100 Burjassot, Spain
    Toxicon 56:418-24. 2010
    ..5 microM. This study indicates that ENs, fungal metabolites that are commonly found in corn and in general in product composed by corn, may have a toxic potential for human health...
  15. doi Interaction effects of Fusarium enniatins (A, A1, B and B1) combinations on in vitro cytotoxicity of Caco-2 cells
    A Prosperini
    Laboratory of Food Chemistry and Toxicology, Faculty of Pharmacy, University of Valencia, Av Vicent Andres Estelles s n, 46100 Burjassot, Valencia, Spain Electronic address
    Toxicol In Vitro 28:88-94. 2014
    ..76-10.36). The use of combination index-isobole method could help to better understand the potential interaction between co-occurring mycotoxins and may contribute to their risk assessment. ..