Affiliation: University of Granada
Martinez A, Perojil A, Rivas F, Parra A, Garcia Granados A, Fernandez Vivas A. Biotransformation of oleanolic and maslinic methyl esters by Rhizomucor miehei CECT 2749. Phytochemistry. 2015;117:500-8 pubmed publisher
..The structures of these derivatives were deduced by extensive and rigorous spectroscopic studies. ..
Medina O Donnell M, Rivas F, Reyes Zurita F, Martinez A, Martin Fonseca S, Garcia Granados A, et al
. Semi-synthesis and antiproliferative evaluation of PEGylated pentacyclic triterpenes. Eur J Med Chem. 2016;118:64-78 pubmed publisher
..These PEGylated derivatives of natural triterpenoids, which can induce apoptosis at very low concentrations in different tumour lines, may represent new effective therapeutic drugs against these diseases. ..
Medina O Donnell M, Rivas F, Reyes Zurita F, Martinez A, LupiaÃ±ez J, Parra A. Diamine and PEGylated-diamine conjugates of triterpenic acids as potential anticancer agents. Eur J Med Chem. 2018;148:325-336 pubmed publisher
..All the compounds analysed, except one, did not cause changes in mitochondrial-membrane potential during apoptosis of the B16-F10 cancer cells, suggesting an activation of the extrinsic apoptotic pathway for these compounds. ..
Medina O Donnell M, Rivas F, Reyes Zurita F, Martinez A, Galisteo González F, Lupiáñez J, et al
. Synthesis and in vitro antiproliferative evaluation of PEGylated triterpene acids. Fitoterapia. 2017;120:25-40 pubmed publisher
..Finally, we have also studied changes in mitochondrial membrane potential during apoptosis of HT29 cancer cells, and the results suggest an activation of the extrinsic apoptotic pathway for these compounds. ..