Jose Luis Rios

Summary

Affiliation: University of Valencia
Country: Spain

Publications

  1. doi request reprint Chemical constituents and pharmacological properties of Poria cocos
    Jose Luis Rios
    Department of Pharmacology, University of Valencia, Valencia, Spain
    Planta Med 77:681-91. 2011
  2. ncbi request reprint Cucurbitacins as inducers of cell death and a rich source of potential anticancer compounds
    J L Rios
    Departament de Farmacologia, Facultat de Farmacia, Universitat de València Av Vicent Andrés Estellés S N, 46100 Burjassot, Valencia, Spain
    Curr Pharm Des 18:1663-76. 2012
  3. ncbi request reprint Traditional chinese medicine remedy to jury: the pharmacological basis for the use of shikonin as an anticancer therapy
    I Andújar
    Departament de Farmacologia, Facultat de Farmacia, Universitat de Valencia, Av Vicent Andres Estelles s n, 46100 Burjassot, Valencia, Spain
    Curr Med Chem 20:2892-8. 2013
  4. ncbi request reprint In vivo anti-inflammatory activity of saponins from Bupleurum rotundifolium
    P Navarro
    Departament de Farmacologia, Facultat de Farmacia, Universitat de Valencia, Burjassot, Spain
    Life Sci 68:1199-206. 2001
  5. doi request reprint Effects of triterpenes on the immune system
    Jose Luis Rios
    Departament de Farmacologia, Facultat de Farmacia, Universitat de Valencia, Av Vicent Andres Estelles s n 46100 Burjassot, Valencia, Spain
    J Ethnopharmacol 128:1-14. 2010
  6. ncbi request reprint Inhibition of transcription factors by plant-derived compounds and their implications in inflammation and cancer
    J L Rios
    Department of Pharmacology, Faculty of Pharmacy, University of Valencia, Spain
    Curr Pharm Des 15:1212-37. 2009
  7. doi request reprint Inhibition of delayed-type hypersensitivity by Cucurbitacin R through the curbing of lymphocyte proliferation and cytokine expression by means of nuclear factor AT translocation to the nucleus
    Jose M Escandell
    Departament de Farmacologia, Facultat de Farmacia, Universitat de Valencia, Av Vicent Andres Estelles s n, 46100 Burjassot, Valencia, Spain
    J Pharmacol Exp Ther 332:352-63. 2010
  8. ncbi request reprint Medicinal plants and antimicrobial activity
    J L Rios
    Departament de Farmacologia, Facultat de Farmacia, Universitat de València Av Vicent Andrés Estellés s n 46100 Burjassot, Valencia, Spain
    J Ethnopharmacol 100:80-4. 2005
  9. ncbi request reprint Anti-inflammatory activity of two cucurbitacins isolated from Cayaponia tayuya roots
    M Carmen Recio
    Departament de Farmacologia, Facultat de Farmacia, Universitat de Valencia, Burjassot, Spain
    Planta Med 70:414-20. 2004
  10. ncbi request reprint Dihydrocucurbitacin B, isolated from Cayaponia tayuya, reduces damage in adjuvant-induced arthritis
    Jose Miguel Escandell
    Departament de Farmacologia, Facultat de Farmacia, Universitat de Valencia, Av Vicent Andres Estelles s n, 46100 Burjassot, Spain
    Eur J Pharmacol 532:145-54. 2006

Collaborators

  • Lidija Klampfer
  • Matthias Hamburger
  • Guillermo R Schinella
  • Alexander I Gray
  • Jose M Prieto
  • Senji Shirasawa
  • Olivier Potterat
  • Han Dong Sun
  • Irmgard Merfort
  • Ammar Bader
  • Salvador Máñez
  • Rosa M Giner
  • M Carmen Recio
  • Rosa María Giner
  • María Carmen Recio
  • Jose M Escandell
  • Isabel Andújar
  • Miguel Cerda-Nicolas
  • Elisa Giner
  • Silvia Aquila
  • María del Carmen Recio
  • Esperanza Bas
  • Marta Marín
  • Luis Góngora
  • Ana Olmos
  • Victoriano Hernández
  • Araceli Sala
  • I Andújar
  • M Cerda-Nicolas
  • María C Recio
  • M C Recio
  • R M Giner
  • Jose Miguel Escandell
  • Zeng Yueqin
  • Eva M Giner-Larza
  • P Navarro
  • José Miguel Cerdá
  • Sara Laghi
  • Jose Miguel Cerda-Nicolas
  • Mariya El Alami
  • Elena Cienfuegos-Jovellanos
  • Begoña Muguerza
  • Jairo Saez
  • Zhi Ying Weng
  • Etile D Spegazzini
  • Yue Qin Zeng
  • Benjamin Rojano
  • Silvia L Debenedetti
  • Takehiko Sasazuki
  • Leonard Augenlicht
  • Pawan Kaler
  • Rosario Gil-Benso
  • Mohamed Abdallah
  • Concha Lopez-Gines
  • Maite Prieto
  • Cecilia Orsi
  • Marina Bonucelli
  • Rosa Marfa Giner
  • Horacio Tournier
  • MaríadelCarmen Recio
  • S Máñez

Detail Information

Publications42

  1. doi request reprint Chemical constituents and pharmacological properties of Poria cocos
    Jose Luis Rios
    Department of Pharmacology, University of Valencia, Valencia, Spain
    Planta Med 77:681-91. 2011
    ..In addition, they showed antitumor activity against different cancer cell lines. This activity is associated with their capacity to inhibit angiogenesis by downregulating both NF- κB and the induction of NF- κB/Rel translocation...
  2. ncbi request reprint Cucurbitacins as inducers of cell death and a rich source of potential anticancer compounds
    J L Rios
    Departament de Farmacologia, Facultat de Farmacia, Universitat de València Av Vicent Andrés Estellés S N, 46100 Burjassot, Valencia, Spain
    Curr Pharm Des 18:1663-76. 2012
    ..Taking all these effects into account, cucurbitacins may prove useful in the treatment of different kinds of cancers, especially when used with other cytostatic agents...
  3. ncbi request reprint Traditional chinese medicine remedy to jury: the pharmacological basis for the use of shikonin as an anticancer therapy
    I Andújar
    Departament de Farmacologia, Facultat de Farmacia, Universitat de Valencia, Av Vicent Andres Estelles s n, 46100 Burjassot, Valencia, Spain
    Curr Med Chem 20:2892-8. 2013
    ....
  4. ncbi request reprint In vivo anti-inflammatory activity of saponins from Bupleurum rotundifolium
    P Navarro
    Departament de Farmacologia, Facultat de Farmacia, Universitat de Valencia, Burjassot, Spain
    Life Sci 68:1199-206. 2001
    ..Their ID50 were determined to be 248, 288, 128, 99 and 297 nmol/ear for saponin 1, 2, 3, 4 and 6, respectively. Saponins 3 and 6 were also active on a TPA multiple-dose model of skin chronic inflammation...
  5. doi request reprint Effects of triterpenes on the immune system
    Jose Luis Rios
    Departament de Farmacologia, Facultat de Farmacia, Universitat de Valencia, Av Vicent Andres Estelles s n 46100 Burjassot, Valencia, Spain
    J Ethnopharmacol 128:1-14. 2010
    ..Several of them are implicated in the resolution of immune diseases, although their effects have not always been clearly correlated...
  6. ncbi request reprint Inhibition of transcription factors by plant-derived compounds and their implications in inflammation and cancer
    J L Rios
    Department of Pharmacology, Faculty of Pharmacy, University of Valencia, Spain
    Curr Pharm Des 15:1212-37. 2009
    ..This review focuses mainly on the effects of natural products on transcription factors, which are the most promising targets for designing new active drugs against inflammation and cancer...
  7. doi request reprint Inhibition of delayed-type hypersensitivity by Cucurbitacin R through the curbing of lymphocyte proliferation and cytokine expression by means of nuclear factor AT translocation to the nucleus
    Jose M Escandell
    Departament de Farmacologia, Facultat de Farmacia, Universitat de Valencia, Av Vicent Andres Estelles s n, 46100 Burjassot, Valencia, Spain
    J Pharmacol Exp Ther 332:352-63. 2010
    ..In conclusion, cucurbitacin R has the potential to be a new immunosuppressive agent with antiproliferative effects through the inhibition of the NFAT with anti-inflammatory activity in DTH reactions...
  8. ncbi request reprint Medicinal plants and antimicrobial activity
    J L Rios
    Departament de Farmacologia, Facultat de Farmacia, Universitat de València Av Vicent Andrés Estellés s n 46100 Burjassot, Valencia, Spain
    J Ethnopharmacol 100:80-4. 2005
    ..Of utmost relevance is the definition of common parameters, such as plant material, techniques employed, growth medium and microorganisms tested...
  9. ncbi request reprint Anti-inflammatory activity of two cucurbitacins isolated from Cayaponia tayuya roots
    M Carmen Recio
    Departament de Farmacologia, Facultat de Farmacia, Universitat de Valencia, Burjassot, Spain
    Planta Med 70:414-20. 2004
    ..Neither compound modified the production of LTB4 in rat polymorphonuclear leukocytes, nor did they exhibit analgesic properties at the dose assayed...
  10. ncbi request reprint Dihydrocucurbitacin B, isolated from Cayaponia tayuya, reduces damage in adjuvant-induced arthritis
    Jose Miguel Escandell
    Departament de Farmacologia, Facultat de Farmacia, Universitat de Valencia, Av Vicent Andres Estelles s n, 46100 Burjassot, Spain
    Eur J Pharmacol 532:145-54. 2006
    ..In addition, it decreased the tumor necrosis factor-alpha and interleukin-1beta production in lymphocytes, but did not modify it in macrophages...
  11. ncbi request reprint New insight into the inhibition of the inflammatory response to experimental delayed-type hypersensitivity reactions in mice by scropolioside A
    Esperanza Bas
    Departament de Farmacologia, Facultat de Farmacia, Universitat de Valencia, Av Vicent Andres Estelles s n, 46100 Burjassot, Spain
    Eur J Pharmacol 555:199-210. 2007
    ..Moreover, it modified the expression of both nitric oxide synthase-2 and cyclooxygenase-2, as well as the activation of nuclear factor-kappaB in RAW 264.7 macrophages...
  12. ncbi request reprint A new dual inhibitor of arachidonate metabolism isolated from Helichrysum italicum
    Araceli Sala
    Departament de Farmacologia, Facultat de Farmacia, Universitat de Valencia, Av Vicent Andres Estelles s n 46100 Burjassot, Spain
    Eur J Pharmacol 460:219-26. 2003
    ..In conclusion acetophenone 1 (4-hydroxy-3-(3-methyl-2-butenyl)acetophenone) is a new dual inhibitor of arachidonate metabolism, and could be a useful tool for obtaining anti-inflammatory and analgesic drugs...
  13. ncbi request reprint Isolation of two triterpenoids and a biflavanone with anti-Inflammatory activity from Schinus molle fruits
    Zeng Yueqin
    Departament de Farmacologia, Facultat de Farmacia, Universitat de Valencia, Burjassot, Valencia, Spain
    Planta Med 69:893-8. 2003
    ..In addition, 3 inhibited the LTB (4) production in rat peritoneal polymorphonuclear leukocytes with an IC (50) value of 29.8 microM, while triterpenes showed toxicity against cells at 100 microM...
  14. ncbi request reprint Inhibition of the pro-inflammatory mediators' production and anti-inflammatory effect of the iridoid scrovalentinoside
    Esperanza Bas
    Departament de Farmacologia, Facultat de Farmacia, Universitat de Valencia, Av Vicent Andres Estelles s n, 46100 Burjassot, Spain
    J Ethnopharmacol 110:419-27. 2007
    ..Finally, scrovalentinoside inhibited the production of the pro-inflammatory mediators' TNF-alpha, IFN-gamma, IL-1beta, IL-2, IL-4, LTB(4), and NO, but had no effect on the production of the anti-inflammatory cytokine IL-10...
  15. ncbi request reprint Inhibition of xanthine oxidase by phenolic conjugates of methylated quinic acid
    Luis Góngora
    Departament de Farmacologia, Facultat de Farmacia, Universitat de Valencia, Burjassot, Spain
    Planta Med 69:396-401. 2003
    ....
  16. ncbi request reprint Anti-inflammatory triterpenes from Pistacia terebinthus galls
    Eva M Giner-Larza
    Departament de Farmacologia, Facultat de Farmacia, Universitat de Valencia, Burjassot, Valencia, Spain
    Planta Med 68:311-5. 2002
    ..The pharmacological activity of the compounds was ratified by a histological study of the ear samples. In addition, they inhibited leukotriene B4 production in rat polymorphonuclear leukocytes stimulated with calcium ionophore A 23187...
  17. ncbi request reprint Effects of caffeoyl conjugates of isoprenyl-hydroquinone glucoside and quinic acid on leukocyte function
    Luis Góngora
    Departament de Farmacologia, Facultat de Farmacia, Universitat de Valencia, Avda Vicent Andres Estelles s n, 46100 Burjassot, Valencia, Spain
    Life Sci 71:2995-3004. 2002
    ....
  18. ncbi request reprint Isoprenylhydroquinone glucoside: a new non-antioxidant inhibitor of peroxynitrite-mediated tyrosine nitration
    Ana Olmos
    Departament de Farmacologia, Universitat de Valencia, Facultat de Farmacia, 46100 Burjassot, Spain
    Nitric Oxide 12:54-60. 2005
    ....
  19. ncbi request reprint Anti-inflammatory and antiallergic activity in vivo of lipophilic Isatis tinctoria extracts and tryptanthrin
    María Carmen Recio
    Department of Pharmacology, Faculty of Pharmacy, University of Valencia, Valencia, Spain
    Planta Med 72:539-46. 2006
    ..The extract had no effect in this model when administered orally. The DCM extract (200 mg/kg P. O.) inhibited the acetic acid-induced writhing by 49%...
  20. ncbi request reprint Dihydrocucurbitacin B inhibits delayed type hypersensitivity reactions by suppressing lymphocyte proliferation
    Jose M Escandell
    Departament de Farmacologia, Facultat de Farmacia, Universitat de Valencia, Av Vicent Andres Estelles s n, 46100 Burjassot, Spain
    J Pharmacol Exp Ther 322:1261-8. 2007
    ..Taken together, these results suggest that dihydrocucurbitacin B curbs DTH reactions by inhibiting NFAT, which in turn suppresses the proliferation of the most relevant cells involved in DTH reactions, namely the T cells...
  21. ncbi request reprint Modulation of protein tyrosine nitration and inflammatory mediators by isoprenylhydroquinone glucoside
    Ana Olmos
    Departament de Farmacologia, Facultat de Farmacia, Universitat de Valencia, Av Vicent Andres Estelles s n, 46100 Burjassot, Spain
    Eur J Pharm Sci 30:220-8. 2007
    ..Thus, isoprenylhydroquinone glucoside is an inhibitor of protein nitration in situ, but lacks effect on the generation of either nitric oxide or inflammatory cytokines...
  22. ncbi request reprint Anti-inflammatory activity of 5-O-demethylnobiletin, a polymethoxyflavone isolated from Sideritis tragoriganum
    Esperanza Bas
    Departament de Farmacologia, Facultat de Farmacia, Universitat de Valencia, Av Vicent Andres Estelles s n, 46100 Burjassot, Valencia, Spain
    Planta Med 72:136-42. 2006
    ..7 macrophages. These experimental results suggest that 1 may act through a direct inhibition of 5-LOX, without affecting the expression of COX-2...
  23. ncbi request reprint Anti-inflammatory and antioxidant properties of Helichrysum italicum
    Araceli Sala
    Departament de Farmacologia, Facultat de Farmacia, Universitat de Valencia, Spain
    J Pharm Pharmacol 54:365-71. 2002
    ..We conclude that the anti-inflammatory activity of Helichrysum italicum can be explained by multiple effects, including inflammatory enzyme inhibition, free-radical scavenging activity and corticoid-like effects...
  24. ncbi request reprint Effects of naturally occurring dihydroflavonols from Inula viscosa on inflammation and enzymes involved in the arachidonic acid metabolism
    Victoriano Hernández
    Departament de Farmacologia, Facultat de Farmacia, Universitat de Valencia, Av Vicent Andres Estelles s n 46100 Burjassot, Spain
    Life Sci 81:480-8. 2007
    ..Finally, none of the flavanones exhibited any effect on MPO or PKC activities. Taken together, these findings indicate that sakuranetin may be a selective inhibitor of 5-LOX...
  25. ncbi request reprint Anti-arthritic activity of a lipophilic woad (Isatis tinctoria) extract
    María Carmen Recio
    Department of Pharmacology, Faculty of Pharmacy, University of Valencia, Spain
    Planta Med 72:715-20. 2006
    ..High dose treatment with Isatis extract for two weeks did not result in macroscopic lesions of the gastric mucosa...
  26. ncbi request reprint Inhibition of pro-inflammatory enzymes by inuviscolide, a sesquiterpene lactone from Inula viscosa
    Salvador Máñez
    Departament de Farmacologia, Facultat de Farmacia, Universitat de Valencia, Avinguda Vicent Andrés Estellés s n, 46100 Burjassot, Spain
    Fitoterapia 78:329-31. 2007
    ..Furthermore, it reduces the skin leukocyte infiltration in a murine model of dermatitis induced by repeated application of 12-O-tetradecanoylphorbol 13-acetate...
  27. doi request reprint Oleuropein protects against dextran sodium sulfate-induced chronic colitis in mice
    Elisa Giner
    Departament de Farmacologia, Facultat de Farmacia, Universitat de Valencia, Burjassot, Spain
    J Nat Prod 76:1113-20. 2013
    ..In addition, 1 ameliorated intestinal wound healing in IEC-18 monolayers. Therefore, oleuropein seems to be a promising active molecule in experimental ulcerative colitis. ..
  28. doi request reprint Oleuropein ameliorates acute colitis in mice
    Elisa Giner
    Departament de Farmacologia, Facultat de Farmacia, Universitat de Valencia, Av Vicent Andres Estelles, 46100 Burjassot, Valencia, Spain
    J Agric Food Chem 59:12882-92. 2011
    ..These results suggest that the effect of oleuropein on DSS-induced colitis is associated with a decrease in the production of interleukins and expression of proteins, principally through reduction of NF-κB activation...
  29. doi request reprint Phenolic substances from Phagnalon rupestre protect against 2,4,6-trinitrochlorobenzene-induced contact hypersensitivity
    Elisa Giner
    Departament de Farmacologia, Facultat de Farmàcia, Universitat de València, Spain
    J Nat Prod 74:1079-84. 2011
    ..7 stimulated with lipopolysaccharide. Thus, compounds 2 and 3 were found to exhibit a greater activity against contact hypersensitivity than 1...
  30. doi request reprint Anti-inflammatory activity of berenjenol and related compounds
    Silvia Aquila
    Departament de Farmacologia, Facultat de Farmacia, Universitat de Valencia, Spain
    Planta Med 75:18-23. 2009
    ....
  31. ncbi request reprint Cucurbitacin R reduces the inflammation and bone damage associated with adjuvant arthritis in lewis rats by suppression of tumor necrosis factor-alpha in T lymphocytes and macrophages
    Jose M Escandell
    Departament de Farmacologia, Facultat de Farmacia, Universitat de Valencia, Av Vicent Andres Estelles s n, 46100 Burjassot, Spain
    J Pharmacol Exp Ther 320:581-90. 2007
    ....
  32. ncbi request reprint Phenolic glycosides from Phagnalon rupestre
    Luis Góngora
    Departament de Farmacologia, Facultat de Farmacia, Universitat de Valencia, Avinguda Vicent Andrés Estellés s n, 46100 Burjassot, Valencia, Spain
    Phytochemistry 59:857-60. 2002
    ..The known flavonoids apigenin-7-O-beta-glucoside, luteolin-7-O-beta-glucoside, luteolin-7-O-beta-glucuronide and the acetophenone picein were also isolated...
  33. doi request reprint Anti-inflammatory activity of flavonoids from Cayaponia tayuya roots
    Silvia Aquila
    Departament de Farmacologia, Facultat de Farmacia, Universitat de Valencia, Spain
    J Ethnopharmacol 121:333-7. 2009
    ....
  34. ncbi request reprint Screening of some rare endemic Italian plants for inhibitory activity on 5-lipoxygenase
    José Maria Prieto
    Departament de Farmacologia, Facultat de Farmacia, Universitat de Valencia, Av Vicent Andres Estelles, s n 46100 Burjassot, Valencia, Spain
    Fitoterapia 76:725-7. 2005
    ..The methanol extracts of pods of Cytisus aeolicus and aerial parts of Thymus richardii were the most active extracts, inhibiting almost completely the leukotriene B4 production at 200 and 50 microg/ml, respectively...
  35. pmc Activated kRas protects colon cancer cells from cucurbitacin-induced apoptosis: the role of p53 and p21
    Jose M Escandell
    Departament de Farmacologia, Facultat de Farmacia, Universitat de Valencia, Burjassot 46100, Spain
    Biochem Pharmacol 76:198-207. 2008
    ....
  36. doi request reprint Inhibition of ulcerative colitis in mice after oral administration of a polyphenol-enriched cocoa extract is mediated by the inhibition of STAT1 and STAT3 phosphorylation in colon cells
    Isabel Andújar
    Departament de Farmacologia, Facultat de Farmàcia, Universitat de València, Spain
    J Agric Food Chem 59:6474-83. 2011
    ..This effect is principally due to the inhibition of transcription factors STAT1 and STAT3 in intestinal cells, with NF-κB inhibition also being implicated...
  37. ncbi request reprint Tiliroside and gnaphaliin inhibit human low density lipoprotein oxidation
    Guillermo R Schinella
    Catedra de Farmacologia, Facultad de Ciencias Medicas, Universidad Nacional de La Plata, Argentina
    Fitoterapia 78:1-6. 2007
    ..6+/-2.5 microM vs. IC(50)>50 microM). In conclusion, tiliroside and gnaphaliin are antioxidants against in vitro Cu(2+)-induced LDL oxidation in the same order of magnitude compared to that of the reference drug, probucol...
  38. doi request reprint Pharmacological Properties of Shikonin - A Review of Literature since 2002
    Isabel Andújar
    Departament de Farmacologia, Facultat de Farmacia, Universitat de Valencia, Valencia, Spain
    Planta Med 79:1685-97. 2013
    ..The aim of this review is to provide an update of the new data published on shikonin, whose wide spectrum of pharmacological effects as well as pharmacokinetic properties and toxicity make it a highly interesting target molecule. ..
  39. pmc Beneficial effect of shikonin on experimental colitis induced by dextran sulfate sodium in BALB/c mice
    Isabel Andújar
    Departamento de Farmacologia, Facultat de Farmacia, Universitat de Valencia, Burjassot, 46100 Valencia, Spain
    Evid Based Complement Alternat Med 2012:271606. 2012
    ..Shikonin acts by blocking the activation of two major targets: NF-κB and STAT-3, and thus constitutes a promising potential therapeutic agent for the management of the inflammatory bowel disease...
  40. doi request reprint Inhibition of NF-kappaB activation and iNOS induction by ent-kaurane diterpenoids in LPS-stimulated RAW264.7 murine macrophages
    Silvia Aquila
    Departament de Farmacologia, Universitat de Valencia, Avenida Vicent Andres Estelles s n, 46100 Burjassot, Valencia, Spain
    J Nat Prod 72:1269-72. 2009
    ..These findings indicate that ent-kauranes are potential anti-inflammatory agents, with a specific mechanism in which both the inhibition of NF-kappaB translocation and the consequent decrease of pro-inflammatory mediators are implicated...
  41. doi request reprint Intestinal anti-inflammatory activity of ellagic acid in the acute and chronic dextrane sulfate sodium models of mice colitis
    Marta Marín
    Department of Pharmacology, Faculty of Pharmacy, University of Valencia Avda Vicent Andrés Estellés sn, 46100 Burjassot Valencia, Spain
    J Ethnopharmacol 150:925-34. 2013
    ..To evaluate the anti-inflammatory effects of ellagic acid on dextran sulfate sodium (DSS)-induced acute and chronic experimental colitis in two different strains of mice and to elucidate its possible mechanisms of action...
  42. doi request reprint Protective effect of apocynin in a mouse model of chemically-induced colitis
    Marta Marín
    Departament de Farmacologia, Facultat de Farmacia, Universitat de Valencia, Valencia, Spain
    Planta Med 79:1392-400. 2013
    ..These results are promising for further experimental studies on treating gastrointestinal diseases and on the potential protective effects of apocynin. ..