Jose L Quiles

Summary

Affiliation: University of Granada
Country: Spain

Publications

  1. ncbi request reprint Vitamin E supplementation increases the stability and the in vivo antioxidant capacity of refined olive oil
    J L Quiles
    Institute of Nutrition and Food Technology, Department of Physiology, University of Granada, Spain
    Free Radic Res 31:S129-35. 1999
  2. ncbi request reprint Physical exercise affects the lipid profile of mitochondrial membranes in rats fed with virgin olive oil or sunflower oil
    J L Quiles
    Institute of Nutrition and Food Technology INYTA, University of Granada, Spain
    Br J Nutr 81:21-4. 1999
  3. pmc Autophagy in periodontitis patients and gingival fibroblasts: unraveling the link between chronic diseases and inflammation
    Pedro Bullon
    Dipartimento di Scienze Cliniche Specialistiche ed Odontostomatologiche Sezione Biochimica, Universita Politecnica delle Marche, Via Ranieri, 65, Ancona, 60100, Italia
    BMC Med 10:122. 2012
  4. ncbi request reprint Dietary fat (virgin olive oil or sunflower oil) and physical training interactions on blood lipids in the rat
    Jose L Quiles
    Institute of Nutrition and Food Technology, Department of Physiology, University of Granada, Granada, Spain
    Nutrition 19:363-8. 2003
  5. ncbi request reprint Coenzyme Q concentration and total antioxidant capacity of human milk at different stages of lactation in mothers of preterm and full-term infants
    Jose L Quiles
    Institute of Nutrition and Food Technology, University of Granada, Department of Physiology, Granada, Spain
    Free Radic Res 40:199-206. 2006
  6. ncbi request reprint Dietary fat type (virgin olive vs. sunflower oils) affects age-related changes in DNA double-strand-breaks, antioxidant capacity and blood lipids in rats
    Jose L Quiles
    Department of Physiology, Institute of Nutrition and Food Technology, University of Granada, C Ramón y Cajal 4 Edificio Fray Luis, Granada 18071, Spain
    Exp Gerontol 39:1189-98. 2004
  7. ncbi request reprint Age-related mitochondrial DNA deletion in rat liver depends on dietary fat unsaturation
    Jose L Quiles
    Department of Physiology, Institute of Nutrition and Food Technology, University of Granada, Spain
    J Gerontol A Biol Sci Med Sci 61:107-14. 2006
  8. ncbi request reprint Coenzyme Q supplementation protects from age-related DNA double-strand breaks and increases lifespan in rats fed on a PUFA-rich diet
    Jose L Quiles
    Department of Physiology, Institute of Nutrition and Food Technology, University of Granada, Ramón y Cajal 4 Edif Fray Luis de Granada, Granada 18071, Spain
    Exp Gerontol 39:189-94. 2004
  9. ncbi request reprint Coenzyme Q differentially modulates phospholipid hydroperoxide glutathione peroxidase gene expression and free radicals production in malignant and non-malignant prostate cells
    J L Quiles
    Institute of Nutrition and Food Technology, University of Granada, Spain
    Biofactors 18:265-70. 2003
  10. ncbi request reprint Life-long supplementation with a low dosage of coenzyme Q10 in the rat: effects on antioxidant status and DNA damage
    Jose L Quiles
    Institute of Nutrition and Food Technology, Department of Physiology, University of Granada, Spain
    Biofactors 25:73-86. 2005

Collaborators

Detail Information

Publications43

  1. ncbi request reprint Vitamin E supplementation increases the stability and the in vivo antioxidant capacity of refined olive oil
    J L Quiles
    Institute of Nutrition and Food Technology, Department of Physiology, University of Granada, Spain
    Free Radic Res 31:S129-35. 1999
    ..In conclusion, the supplementation of refined olive oil with 200 mg/kg of vitamin E increases the stability of this oil under pro-oxidant conditions, and its intake decreases the oxidative damage generated by adriamycin in rats...
  2. ncbi request reprint Physical exercise affects the lipid profile of mitochondrial membranes in rats fed with virgin olive oil or sunflower oil
    J L Quiles
    Institute of Nutrition and Food Technology INYTA, University of Granada, Spain
    Br J Nutr 81:21-4. 1999
    ..05). These changes due to the exercise may arise via several mechanisms, e.g. fluidity regulation; changes in the eicosanoid metabolism; differences in the availability or oxidation rate of the different fatty acids...
  3. pmc Autophagy in periodontitis patients and gingival fibroblasts: unraveling the link between chronic diseases and inflammation
    Pedro Bullon
    Dipartimento di Scienze Cliniche Specialistiche ed Odontostomatologiche Sezione Biochimica, Universita Politecnica delle Marche, Via Ranieri, 65, Ancona, 60100, Italia
    BMC Med 10:122. 2012
    ..Thus it is important to study the role of autophagy in the pathophysiology of periodontitis...
  4. ncbi request reprint Dietary fat (virgin olive oil or sunflower oil) and physical training interactions on blood lipids in the rat
    Jose L Quiles
    Institute of Nutrition and Food Technology, Department of Physiology, University of Granada, Granada, Spain
    Nutrition 19:363-8. 2003
    ..We investigated whether the intake of virgin olive oil or sunflower oil and performance of physical exercise (at different states) affect plasma levels of triacylglycerols, total cholesterol, and fatty acid profile in rats...
  5. ncbi request reprint Coenzyme Q concentration and total antioxidant capacity of human milk at different stages of lactation in mothers of preterm and full-term infants
    Jose L Quiles
    Institute of Nutrition and Food Technology, University of Granada, Department of Physiology, Granada, Spain
    Free Radic Res 40:199-206. 2006
    ..CoQ10 in breast milk decreases through lactation in mothers delivering full-term infants. Also, CoQ10, alpha- and gamma-tocopherol concentration in human milk directly correlates with the antioxidant capacity of the milk...
  6. ncbi request reprint Dietary fat type (virgin olive vs. sunflower oils) affects age-related changes in DNA double-strand-breaks, antioxidant capacity and blood lipids in rats
    Jose L Quiles
    Department of Physiology, Institute of Nutrition and Food Technology, University of Granada, C Ramón y Cajal 4 Edificio Fray Luis, Granada 18071, Spain
    Exp Gerontol 39:1189-98. 2004
    ..In the present study best results were found after intake of virgin olive oil, which suggest the possible use of that edible oil to provide a healthier aging...
  7. ncbi request reprint Age-related mitochondrial DNA deletion in rat liver depends on dietary fat unsaturation
    Jose L Quiles
    Department of Physiology, Institute of Nutrition and Food Technology, University of Granada, Spain
    J Gerontol A Biol Sci Med Sci 61:107-14. 2006
    ..Results suggest that the age-related increase of the relative amount of deleted mtDNA depends on fat unsaturation. Moreover, the studied mtDNA deletion was correlated with mitochondrial oxidative stress and ultrastructural alterations...
  8. ncbi request reprint Coenzyme Q supplementation protects from age-related DNA double-strand breaks and increases lifespan in rats fed on a PUFA-rich diet
    Jose L Quiles
    Department of Physiology, Institute of Nutrition and Food Technology, University of Granada, Ramón y Cajal 4 Edif Fray Luis de Granada, Granada 18071, Spain
    Exp Gerontol 39:189-94. 2004
    ..e. 6 months) than non-supplemented animals. These results suggest that a long-term supplementation with a small dosage of coenzyme Q(10) might represent a good anti-aging therapy in rats fed on a PUFA-based diet...
  9. ncbi request reprint Coenzyme Q differentially modulates phospholipid hydroperoxide glutathione peroxidase gene expression and free radicals production in malignant and non-malignant prostate cells
    J L Quiles
    Institute of Nutrition and Food Technology, University of Granada, Spain
    Biofactors 18:265-70. 2003
    ..If these results are confirmed with additional experiments, it could represent a novel and interesting approach on the biomedical use of coenzyme Q10 in cancer therapy...
  10. ncbi request reprint Life-long supplementation with a low dosage of coenzyme Q10 in the rat: effects on antioxidant status and DNA damage
    Jose L Quiles
    Institute of Nutrition and Food Technology, Department of Physiology, University of Granada, Spain
    Biofactors 25:73-86. 2005
    ..In addition, CoQ(10) supplementation attenuates the age-related fall in total antioxidant capacity of plasma and the increase in DNA damage in peripheral blood lymphocytes...
  11. ncbi request reprint Antioxidant nutrients and adriamycin toxicity
    Jose L Quiles
    Department of Physiology, Institute of Nutrition and Food Technology, University of Granada, Ramon y Cajal 4, Spain
    Toxicology 180:79-95. 2002
    ....
  12. ncbi request reprint Olive oil phenolics: effects on DNA oxidation and redox enzyme mRNA in prostate cells
    Jose L Quiles
    Institute of Nutrition and Food Technology, Department of Physiology, University of Granada, Granada, Spain
    Br J Nutr 88:225-34; discussion 223-4. 2002
    ..Tyrosol appeared to exhibit pro-oxidant effects (only at high concentrations) and caffeic acid was neutral. Both number and position of hydroxyl groups appear to play a role in the cellular effects of hydroxytyrosol...
  13. doi request reprint Coenzyme Q addition to an n-6 PUFA-rich diet resembles benefits on age-related mitochondrial DNA deletion and oxidative stress of a MUFA-rich diet in rat heart
    Jose L Quiles
    Institute of Nutrition and Food Technology José Mataix Verdú, Department of Physiology, University of Granada, Granada, Spain
    Mech Ageing Dev 131:38-47. 2010
    ..Moreover, under our experimental conditions, lipid-derived oxidative damage appears to be more important than the pure protein-derived oxidative damage during aging...
  14. ncbi request reprint The intake of fried virgin olive or sunflower oils differentially induces oxidative stress in rat liver microsomes
    Jose L Quiles
    Institute of Nutrition and Food Technology, Dept of Physiology, University of Granada, Spain
    Br J Nutr 88:57-65. 2002
    ..The highly unsaturated sunflower oil was less resistant to the oxidative stress produced by frying and led to a higher degree of lipid peroxidation in liver microsomes in vivo than virgin olive oil...
  15. ncbi request reprint Effect of lifelong coenzyme Q10 supplementation on age-related oxidative stress and mitochondrial function in liver and skeletal muscle of rats fed on a polyunsaturated fatty acid (PUFA)-rich diet
    Julio J Ochoa
    Department of Physiology, University of Granada, Granada, Spain
    J Gerontol A Biol Sci Med Sci 62:1211-8. 2007
    ..These findings provide mechanisms to explain the effect of CoQ(10) in extending the life span of animals fed a PUFA-rich diet...
  16. ncbi request reprint Curcuma longa extract supplementation reduces oxidative stress and attenuates aortic fatty streak development in rabbits
    Jose L Quiles
    Department of Physiology, Granada University, Granada, Spain
    Arterioscler Thromb Vasc Biol 22:1225-31. 2002
    ..This study evaluates the effect of a Curcuma longa extract on the development of experimental atherosclerosis (fatty streak) in rabbits and its interaction with other plasmatic antioxidants...
  17. ncbi request reprint Oral administration of a turmeric extract inhibits erythrocyte and liver microsome membrane oxidation in rabbits fed with an atherogenic diet
    M Dolores Mesa
    Department of Biochemistry and Molecular Biology, Granada, Spain
    Nutrition 19:800-4. 2003
    ....
  18. ncbi request reprint Aging-related oxidative stress depends on dietary lipid source in rat postmitotic tissues
    Julio J Ochoa
    Department of Physiology, Institute of Nutrition and Food Technology, University of Granada, Granada, Spain
    J Bioenerg Biomembr 35:267-75. 2003
    ..This study confirms that postmitotic tissues are more prone to oxidative stress during aging and proposes a hypothesis to explain this phenomenon...
  19. doi request reprint Age-related changes in brain mitochondrial DNA deletion and oxidative stress are differentially modulated by dietary fat type and coenzyme Q₁₀
    Julio J Ochoa
    Institute of Nutrition and Food Technology José Mataix Verdú, University of Granada, 18071 Granada, Spain
    Free Radic Biol Med 50:1053-64. 2011
    ....
  20. ncbi request reprint Coenzyme Q10 protects from aging-related oxidative stress and improves mitochondrial function in heart of rats fed a polyunsaturated fatty acid (PUFA)-rich diet
    Julio J Ochoa
    Institute of Nutrition and Food Technology, Department of Physiology, University of Granada, Spain
    J Gerontol A Biol Sci Med Sci 60:970-5. 2005
    ....
  21. ncbi request reprint Ageing-related tissue-specific alterations in mitochondrial composition and function are modulated by dietary fat type in the rat
    Jose L Quiles
    Department of Physiology, Institute of Nutrition and Food Technology, University of Granada, C Ramon y Cajal 4, 18071 Granada, Spain
    J Bioenerg Biomembr 34:517-24. 2002
    ..Since high levels of cytochrome b have been related to increased age, it could be hypothesized that olive oil could lead to less aged mitochondria...
  22. ncbi request reprint Oxidative stress in erythrocytes from premature and full-term infants during their first 72 h of life
    Julio J Ochoa
    Institute of Nutrition and Food Technology INYTA, Granada, Spain
    Free Radic Res 37:317-22. 2003
    ....
  23. ncbi request reprint Dietary oils high in oleic acid but with different unsaponifiable fraction contents have different effects in fatty acid composition and peroxidation in rabbit LDL
    Julio J Ochoa
    Institute of Nutrition and Food Technology, University of Granada, Granada, Spain
    Nutrition 18:60-5. 2002
    ..We investigated the influence of different edible oils high in oleic acid but with different unsaponifiable fractions on the fatty acid composition and lipid peroxidation in plasma and low-density lipoprotein (LDL) in rabbits...
  24. ncbi request reprint Oxidative stress status in liver mitochondria and lymphocyte DNA damage of atherosclerotic rabbits supplemented with water soluble coenzyme Q10
    M Carmen Ramirez-Tortosa
    Department of Biochemistry and Molecular Biology II, Institute of Nutrition and Food Technology INYTA, University of Granada, Granada, Spain
    Biofactors 32:263-73. 2008
    ..The findings suggest that antioxidant therapy with coenzyme Q10 may be used in the treatment of liver pathologies associated to the intake of high-fat, atherogenic, diets...
  25. ncbi request reprint Monounsaturated and omega-3 but not omega-6 polyunsaturated fatty acids improve hepatic fibrosis in hypercholesterolemic rabbits
    Concepcion M Aguilera
    Department of Biochemistry and Molecular Biology, Institute of Nutrition and Food Technology, University of Granada, Granada, Spain
    Nutrition 21:363-71. 2005
    ....
  26. ncbi request reprint Oxidative stress status in an institutionalised elderly group after the intake of a phenolic-rich dessert
    M Carmen Ramirez-Tortosa
    Department of Biochemistry and Molecular Biology, Institute of Nutrition and Food Technology, University of Granada, Campus de Cartuja, 18071 Granada, Spain
    Br J Nutr 91:943-50. 2004
    ..Moreover, a highly oxidative stress status during ageing was confirmed, together with the need to perform follow-up nutritional studies to improve this situation...
  27. doi request reprint Hydroxytyrosol ameliorates oxidative stress and mitochondrial dysfunction in doxorubicin-induced cardiotoxicity in rats with breast cancer
    Sergio Granados-Principal
    Department of Biochemistry and Molecular Biology II, Biomedical Research Center, Granada, Spain José Mataix Institute of Nutrition and Food Technology, Biomedical Research Center, Granada, Spain
    Biochem Pharmacol 90:25-33. 2014
    ..This study demonstrates that hydroxytyrosol protect rat heart damage provoked by doxorubicin decreasing oxidative damage and mitochondrial alterations. ..
  28. doi request reprint Squalene ameliorates atherosclerotic lesions through the reduction of CD36 scavenger receptor expression in macrophages
    Sergio Granados-Principal
    Department of Biochemistry and Molecular Biology II, University of Granada, Granada, Spain
    Mol Nutr Food Res 56:733-40. 2012
    ..We investigated the effects of minor compounds of OO (squalene (SQ), tyrosol (Tyr) and hydroxytyrosol (OH-Tyr)), on the expression of the CD36 receptor, as well as on monocyte/macrophage differentiation and proliferation...
  29. doi request reprint Curcumin and liver disease
    Laura Vera-Ramirez
    GENyO Center Pfizer University of Granada and Andalusian Government Centre for Genomics and Oncology, Granada, Spain
    Biofactors 39:88-100. 2013
    ..Because curcumin is a micronutrient that is closely related to cellular redox balance, its properties and activity give rise to a series of molecular reactions that in every case and biological situation affect the mitochondria...
  30. doi request reprint Hydroxytyrosol: from laboratory investigations to future clinical trials
    Sergio Granados-Principal
    Institute of Nutrition and Food Technology José Mataix Verdú, University of Granada, Granada, Spain
    Nutr Rev 68:191-206. 2010
    ..New evidence and strategies regarding the use of hydroxytyrosol as a natural drug for the prevention and treatment of diseases with high incidences in Western countries are also presented...
  31. doi request reprint Coenzyme Q Protects Against Age-Related Alveolar Bone Loss Associated to n-6 Polyunsaturated Fatty Acid Rich-Diets by Modulating Mitochondrial Mechanisms
    Alfonso Varela-Lopez
    Department of Physiology, Institute of Nutrition and Food Technology José Mataix Verdú, University of Granada, Spain
    J Gerontol A Biol Sci Med Sci 71:593-600. 2016
    ....
  32. doi request reprint New advances in molecular mechanisms and the prevention of adriamycin toxicity by antioxidant nutrients
    Sergio Granados-Principal
    Department of Biochemistry and Molecular Biology II, Institute of Nutrition and Food Technology José Mataix Verdú, University of Granada, Granada, Spain
    Food Chem Toxicol 48:1425-38. 2010
    ....
  33. doi request reprint Hydroxytyrosol inhibits growth and cell proliferation and promotes high expression of sfrp4 in rat mammary tumours
    Sergio Granados-Principal
    Department of Biochemistry and Molecular Biology II, University of Granada, Granada, Spain
    Mol Nutr Food Res 55:S117-26. 2011
    ..The aim of this study was to investigate, for the first time in an animal model of experimental mammary carcinoma, the anti-cancer ability of hydroxytyrosol and to discover which pathways are modified by hydroxytyrosol...
  34. pmc Role of Lipids in the Onset, Progression and Treatment of Periodontal Disease. A Systematic Review of Studies in Humans
    Alfonso Varela-Lopez
    Department of Physiology, Institute of Nutrition and Food Technology José Mataix, University of Granada, Biomedical Research Center, Avda Conocimiento s n, 18100 Armilla, Spain
    Int J Mol Sci 17:. 2016
    ..On the other hand, saturated fat-rich diets increase oxidative stress as well the as intensity and duration of inflammatory processes, so they must be avoided. ..
  35. pmc Sunflower Oil but Not Fish Oil Resembles Positive Effects of Virgin Olive Oil on Aged Pancreas after Life-Long Coenzyme Q Addition
    Adrian Gonzalez-Alonso
    Department of Physiology, Institute of Nutrition and Food Technology José Mataix, University of Granada, Biomedical Research Center, lab 250, Avda Conocimiento s n, 18100 Armilla, Granada, Spain
    Int J Mol Sci 16:23425-45. 2015
    ..Therefore CoQ may improve pancreatic alterations associated to the chronic intake of some dietary fat sources. ..
  36. doi request reprint Periodontitis is associated with altered plasma fatty acids and cardiovascular risk markers
    M C Ramirez-Tortosa
    Institute of Nutrition and Food Technology, Department of Biochemistry and Molecular Biology II, University of Granada, Granada, Spain
    Nutr Metab Cardiovasc Dis 20:133-9. 2010
    ....
  37. doi request reprint A Systematic Review on the Implication of Minerals in the Onset, Severity and Treatment of Periodontal Disease
    Alfonso Varela-Lopez
    Department of Physiology, Institute of Nutrition and Food Technology José Mataix, University of Granada, Biomedical Research Center, Avda Conocimiento s n, 18100 Armilla, Granada, Spain
    Molecules 21:. 2016
    ..Lastly, some observations suggest that all those minerals with roles in immune and/or antioxidant systems should be considered in future research. ..
  38. pmc Non-Nutrient, Naturally Occurring Phenolic Compounds with Antioxidant Activity for the Prevention and Treatment of Periodontal Diseases
    Alfonso Varela-Lopez
    Department of Physiology, Institute of Nutrition and Food Technology José Mataix, Biomedical Research Center CIBM, University of Granada, Armilla, Avda del Conocimiento s n, 18100 Armilla, Spain
    Antioxidants (Basel) 4:447-81. 2015
    ....
  39. doi request reprint Coenzyme Q and Its Role in the Dietary Therapy against Aging
    Alfonso Varela-Lopez
    Department of Physiology, Institute of Nutrition and Food Technology José Mataix, Biomedical Research Center CIBM, University of Granada, Avda del Conocimiento s n, Armilla, Granada 18100, Spain
    Molecules 21:373. 2016
    ..In this context, the present review focus on the current knowledge and evidence the roles of CoQ cells, its relationship with aging, and possible implications of dietary CoQ in relation to aging, lifespan or age-related diseases. ..
  40. pmc Oxidative Stress and Dietary Fat Type in Relation to Periodontal Disease
    Alfonso Varela-Lopez
    Institute of Nutrition and Food Technology José Mataix Verdú, Biomedical Research Center CIBM, University of Granada, Avda del Conocimiento s n, Armilla, Granada 18100, Spain
    Antioxidants (Basel) 4:322-44. 2015
    ..Maybe in the future, we should analyze the diet and provide some advice to periodontitis patients to improve treatment outcomes. ..
  41. ncbi request reprint Dietary fat type and regular exercise affect mitochondrial composition and function depending on specific tissue in the rat
    J L Quiles
    Institute of Nutrition and Food Technology, Department of Physiology, University of Granada, Spain
    J Bioenerg Biomembr 33:127-34. 2001
    ..05) among the rats fed sunflower oil. In conclusion, dietary fat type, regular exercise, and the specific tissue modulate composition and function of rat mitochondria...
  42. ncbi request reprint Olive oil supplemented with vitamin E affects mitochondrial coenzyme Q levels in liver of rats after an oxidative stress induced by adriamycin
    J L Quiles
    Nutrition and Food Technology Institute, University of Granada, Spain
    Biofactors 9:331-6. 1999
    ..In conclusion, an increase in coenzyme Q and alpha-tocopherol in these membranes can be a basis for protection against oxidation and improvement in antioxidant capacity...
  43. ncbi request reprint Olive oil and mitochondrial oxidative stress
    J Mataix
    Institute of Nutrition and Food Technology, Department of Physiology, University of Granada, Ramon y Cajal 4, 18071 Granada
    Int J Vitam Nutr Res 76:178-83. 2006
    ..In the same way, virgin olive oil leads to better function of the mitochondrial electron transport chain...