Research Topics
Genomes and Genes | Cheng QianSummaryAffiliation: University of Navarra Country: Spain Publications
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Publications
Targeting toll-like receptor 9 with CpG oligodeoxynucleotides enhances anti-tumor responses of peripheral blood mononuclear cells from human lung cancer patientsTao Ren
Department of Respiratory Medicine, East Hospital, Tongji University, Shanghai, China
Cancer Invest 26:448-55. 2008..Our findings suggest that the CpG-ODN is promising as a preventive and therapeutic anti-tumor measure against pulmonary carcinoma...- Blockade of Wnt signaling inhibits angiogenesis and tumor growth in hepatocellular carcinomaJie Hu
Division of Gene Therapy and Hepatology, Center for Applied Medical Research, University of Navarra, Pamplona, Spain
Cancer Res 69:6951-9. 2009..Our data indicate that Wnt antagonists WIF1-Fc and sFRP1-Fc inhibit Wnt signaling and exert potent antitumor activity by increasing the apoptosis rate in tumor cells and by impairing tumor vascularization... 
Therapy of cancer by cytokines mediated by gene therapy approachCheng Qian
Xinyuan Institute of Medicine and Biotechnology, School of Life Sciences, Zhejiang Sci Tech University, Hangzhou, China
Cell Res 16:182-8. 2006..The combination of cytopathic effect by oncolytic adenovirus and biological effect of transgene would exert strong antitumor activity. These new types of vectors may provide a potent and safe tool for cancer gene therapy...- Gene therapy of cancer: induction of anti-tumor immunityCheng Qian
Division of Hepatology and Gene Therapy, Medical School, Fundacion para la Investigacion Medica Aplicada, University of Navarra, Pamplona, Spain
Cell Mol Immunol 1:105-11. 2004.... - Intratumoral injection of dendritic cells engineered to secrete interleukin-12 by recombinant adenovirus in patients with metastatic gastrointestinal carcinomasGuillermo Mazzolini
Division of Hepatology and Gene Therapy, Department of Radiology, Clinica Universitaria School of Medicine, University of Navarra, C Irunlarrea, S N, 31008 Pamplona, Spain
J Clin Oncol 23:999-1010. 2005..Secondarily, we have evaluated biologic effects and antitumoral activity... - Intrahepatic injection of adenovirus reduces inflammation and increases gene transfer and therapeutic effect in miceJulien Crettaz
Division of Gene Therapy and Hepatology, Center for Applied Medical Research (CIMA, University of Navarra, Pamplona, Spain
Hepatology 44:623-32. 2006..In conclusion, IH injection of adenovirus represents a safe and efficient administration route for clinical applications of gene therapy targeting the liver... - Treatment of cancer with a novel dual-targeted conditionally replicative adenovirus armed with mda-7/IL-24 geneJingjing Luo
Institute of Medicine and Biotechnology, School of Life Sciences, Zhejiang Sci Tech University, Hangzhou, Zhejiang, China
Clin Cancer Res 14:2450-7. 2008..However, better specificity and mode of transgene expression are required to improve the efficacy and safety if this vector is applied for clinical application... - Optimization of the Tet-on system to regulate interleukin 12 expression in the liver for the treatment of hepatic tumorsMaider Zabala
Division of Hepatology and Gene Therapy, School of Medicine, Fundacion para la Investigacion Medica Aplicada (FIMA, University of Navarra, Pamplona, Spain
Cancer Res 64:2799-804. 2004..These data demonstrate the potential of a naked DNA gene therapy strategy to achieve tight control of IL-12 within the liver for the treatment of cancer... - Increased efficacy and safety in the treatment of experimental liver cancer with a novel adenovirus-alphavirus hybrid vectorMin Guan
Division of Hepatology and Gene Therapy, School of Medicine, , University of Navarra, 31008 Pamplona, Spain
Cancer Res 66:1620-9. 2006..This new type of hybrid vectors may provide a potent and safe tool for cancer gene therapy... - Prolonged and inducible transgene expression in the liver using gutless adenovirus: a potential therapy for liver cancerLin Wang
Faculty of Medicine, University of Navarra, Pamplona, Spain
Gastroenterology 126:278-89. 2004..These vectors are promising tools for gene therapy of liver cancer and could also be useful for other forms of hepatic disease... - Biologic therapy of liver tumorsJesus Prieto
Division of Hepatology and Gene Therapy, Fundación para la Investigación Médica Aplicada FIMA, University of Navarra, Avenida Pio XII s n, 31080 Pamplona, Spain
Surg Clin North Am 84:673-96. 2004..Combination of biological modifiers, gene therapy, and cell therapy will hopefully provide efficient means to combat inoperable neoplasms in a not-very-distant future... - The oncolytic adenovirus targeting to TERT and RB pathway induced specific and potent anti-tumor efficacy in vitro and in vivo for hepatocellular carcinomaWei Zhang
Xinyuan Institute of Medicine and Biotechnology, School of Life Sciences, Zhejiang Sci Tech University, Hangzhou, Zhejiang, China
Cancer Biol Ther 6:1726-32. 2007..Oncolytic viruses have been used as targeting therapy for different malignancies. In study, we have engineered oncolytic adenovirus to target both of TERT and RB pathways to achieve strict tumor specificity... - Positron emission tomography imaging of adenoviral-mediated transgene expression in liver cancer patientsIvan Penuelas
Department of Nuclear Medicine, Clinica Universitaria de Navarro, Pamplona, Spain
Gastroenterology 128:1787-95. 2005.... - Generation of full-length functional antibody against preS2 of hepatitis B virus in hepatic cells in vitro from bicistrons mediated by gutless adenovirusYuexiang Yin
Xinyuan Institute of Medicine and Biotechnology, School of Life Sciences, Zhejiang Sci Tech University, Hangzhou, Zhejiang, China
BioDrugs 23:391-7. 2009..However, for the polymeric structure of full-length mAbs, it is important to design an optimal gene transfer system for mAb generation... - Enhanced sensitivity of hepatocellular carcinoma cells to chemotherapy with a Smac-armed oncolytic adenovirusQiu wei Pan
Xin Yuan Institute of Medicine and Biotechnology, Life Science College, Zhejiang Sci Tech University, Hangzhou 310018, China
Acta Pharmacol Sin 28:1996-2004. 2007..The aim of the present study was to further improve the therapeutic effects for human hepatocellular carcinoma (HCC) and reduce the damage in normal cells using a novel chemo-gene-virotherapeutic strategy... - Expression of miR-122 mediated by adenoviral vector induces apoptosis and cell cycle arrest of cancer cellsLeina Ma
Xinyuan Institute of Medicine and Biotechnology, School of Life Sciences, Zhejiang Sci Tech University, Hangzhou, Zhejiang, China
Cancer Biol Ther 9:554-61. 2010..In this study, we presented a novel strategy for cancer therapy based on gene transfer of miR-122 by adenoviral vector... - Influence of the chitosan nature on the transfection efficacy of DNA-loaded nanoparticles after hydrodynamic administration in miceMiguel N Centelles
Centro Galenico, Departamento Farmacia y Tecnología Farmacéutica, University of Navarra, Irunlarrea 1, 31080 Pamplona, Spain
J Microencapsul 27:460-9. 2010.... - Gene therapy of cancer based on interleukin 12Bruno Sangro
Liver Unit, Clinica Universitaria de Navarra, and the Division of Hepatology and Gene Therapy, Centro de Investigación Médica Aplicada, Pamplona, Spain
Curr Gene Ther 5:573-81. 2005..New vectors that might achieve regulated, long-term production of this cytokine might have better results and merit clinical testing... - Synergistic antitumor activity of XIAP-shRNA and TRAIL expressed by oncolytic adenoviruses in experimental HCCQiuwei Pan
Xinyuan Institute of Medicine and Biotechnology, School of Life Science, Zhejiang Sci Tech University, Hangzhou, China
Acta Oncol 47:135-44. 2008..This pilot study offers a promise of using oncolytic adenovirus to deliver siRNA targeting overexpressed oncogenes and a novel strategy for cancer therapy by regulating the equilibrium between the proapoptotic and antiapoptotic factors... - Antitumoral activity of transferrin-lipoplexes carrying the IL-12 gene in the treatment of colon cancerConchita Tros de Ilarduya
Department of Pharmacy and Pharmaceutical Technology, School of Pharmacy, University of Navarra, Pamplona, Spain
J Drug Target 14:527-35. 2006..The vector has the advantages of ease of preparation and economy, in comparison with commercial transfection reagents, as well as, the possibility of a large scale production... - Transfer of suppressor of cytokine signaling 3 by an oncolytic adenovirus induces potential antitumor activities in hepatocellular carcinomaQiang Cui
Xinyuan Institute of Medicine and Biotechnology, School of Life Sciences, Zhejiang Sci Tech University, Hangzhou, China
Hepatology 47:105-12. 2008..Conclusion: This study suggests that transfer of SOCS3 by an oncolytic adenovirus represents a potent approach for cancer therapy... - Suppression of angiogenesis and tumor growth by adenoviral-mediated gene transfer of pigment epithelium-derived factorLin Wang
Division of Hepatology and Gene Therapy, Department of Medicine, Pamplona, Spain
Mol Ther 8:72-9. 2003..These data suggest that the antiangiogenic properties of PEDF can be exploited to inhibit the establishment of tumor neovasculature and reduce tumor growth... 
Mitochondria-dependent apoptosis of con A-activated T lymphocytes induced by asiatic acid for preventing murine fulminant hepatitisWenjie Guo
State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, China
PLoS ONE 7:e46018. 2012..Taken together, our results demonstrated that the ability of asiatic acid to induce apoptosis of activated T cells and its potential use in the treatment of T-cell-mediated inflammatory diseases...- Improving efficacy of interleukin-12-transfected dendritic cells injected into murine colon cancer with anti-CD137 monoclonal antibodies and alloantigensIñigo Tirapu
Gene Therapy Division, Fundacion para la Investigacion Medica Aplicada, University of Navarre, Irunlarrea s n 31008 Pamplona, Navarre, Spain
Int J Cancer 110:51-60. 2004..Supplementary Material for this article can be found on the International Journal of Cancer website at http://www.interscience.wiley.com/jpages/0020-7136/suppmat/index.html... - Inhibition of Th1/Th17 responses via suppression of STAT1 and STAT3 activation contributes to the amelioration of murine experimental colitis by a natural flavonoid glucoside icariinFeifei Tao
State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, China
Biochem Pharmacol 85:798-807. 2013..Taken together, these results indicate that icariin is a potential therapeutic agent for IBD... - Water-soluble andrographolide sulfonate exerts anti-sepsis action in mice through down-regulating p38 MAPK, STAT3 and NF-κB pathwaysWenjie Guo
State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, 22 Han Kou Road, Nanjing 210093, China
Int Immunopharmacol 14:613-9. 2012.... - New methodologies to characterize the effectiveness of the gene transfer mediated by DNA-chitosan nanoparticlesMiguel N Centelles
Centro Galenico, Departamento Farmacia y Tecnología Farmacéutica, University of Navarra, Pamplona, Spain
Int J Nanomedicine 3:451-60. 2008..This fact could be explained by the rapid physiological turn-over of enterocytes and by the ability of chitosan nanoparticles to control the DNA release... - In vitro and in vivo comparative study of chimeric liver-specific promotersM Gabriela Kramer
Division of Hepatology and Gene Therapy, Department of Internal Medicine, School of Medicine, University of Navarra, 31008 Pamplona, Spain
Mol Ther 7:375-85. 2003..We found that among the various chimeric constructs tested in this work, the alpha1-antitrypsin promoter alone or linked to the albumin or hepatitis B enhancers is the most potent in directing stable gene expression in liver cells... - Human adenovirus replicates in immunocompetent models of pancreatic cancer in Syrian hamstersSergia Bortolanza
Gene Therapy Unit, Center for Applied Medical Research, University of Navarra, 31008 Pamplona, Spain
Hum Gene Ther 18:681-90. 2007..In conclusion, the Syrian hamster models described here offer the opportunity to evaluate the effect of oncolytic adenoviruses in an immunocompetent animal and may be a valuable tool in the preclinical evaluation of these agents... - [An efficient tool for the construction of multiple-cistronic vectors: FMDV 2A]Bi Sheng Liu
Xinyuan Institute of Medicine and Biotechnology, School of Life Sciences, Zhejiang Sci Tech University, Hangzhou 310018, China
Sheng Wu Gong Cheng Xue Bao 23:765-9. 2007..In this article, the characteristics and cleavage activities of FMDV 2A will be elucidated,and we further outline its applications in cancer gene therapy... - Liver failure caused by herpes simplex virus thymidine kinase plus ganciclovir therapy is associated with mitochondrial dysfunction and mitochondrial DNA depletionMaite Herraiz
Division of Hepatology and Gene Therapy, University of Navarra, Medical School Pamplona, 31008 Pamplona, Spain
Hum Gene Ther 14:463-72. 2003..These data are relevant for the design of clinical trials using adenoviral vectors encoding HSV-tk... - Synergistic induction of tumor cell death by combining cisplatin with an oncolytic adenovirus carrying TRAILQiuwei Pan
Xin Yuan Institute of Medicine and Biotechnology, Life Science College, Zhejiang Sci Tech University, Hangzhou 310018, China
Mol Cell Biochem 304:315-23. 2007..Thus, a novel chemo-gene-virotherapeutic strategy for cancer therapy was proposed... - Phase I trial of intratumoral injection of an adenovirus encoding interleukin-12 for advanced digestive tumorsBruno Sangro
Liver Unit, Division of Gene Therapy, Department of Internal Medicine, Clinica Universitaria, University of Navarre, Ap 4209 Pamplona 31080, Spain
J Clin Oncol 22:1389-97. 2004..To evaluate the feasibility and safety of intratumoral injection of an adenoviral vector encoding human interleukin-12 genes (Ad.IL-12) and secondarily, its biologic effect for the treatment of advanced digestive tumors... - Anti-ICAM-2 monoclonal antibody synergizes with intratumor gene transfer of interleukin-12 inhibiting activation-induced T-cell deathIgnacio Melero
Centro de Investigación Médica Aplicada CIMA, Facultad de Medicina, Gene Therapy Unit, Universidad de Navarra, 31008 Pamplona, Spain
Clin Cancer Res 9:3546-54. 2003..We sought to design combined therapy strategies with AdCMVIL-12 plus anti-ICAM-2 mAbs and to identify their mechanism of action... - Gene therapy of hepatocellular carcinoma and gastrointestinal tumorsBruno Sangro
Gene Therapy Unit, Department of Internal Medicine, Clinica Universitaria, Universidad de Navarra, Pamplona, Spain
Ann N Y Acad Sci 963:6-12. 2002..In summary, a variety of gene therapy strategies have been effective against animal models of gastrointestinal tumors. Clinical trials should determine whether human patients can be treated safely and effectively by such strategies... - [miR-34s--a tumor suppression protein p53 highly related microRNA]Wen Jia Lou
Xinyuan Institute of Medicine and Biotechnology, College of Life Science, Zhejiang Sci Tech University, Hangzhou 310018, China
Yi Chuan 32:423-30. 2010..This paper summarizes the latest advances of p53 highly related miR-34 families in oncogenesis and treatment... - A novel chromone derivative with anti-inflammatory property via inhibition of ROS-dependent activation of TRAF6-ASK1-p38 pathwayHailiang Liu
State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, Nanjing, China
PLoS ONE 7:e37168. 2012..Blockade of the upstream events required for p38 MAPK action by DCO-6 may provide a new therapeutic option in the treatment of inflammatory diseases... - [piRNA: a novel member of small RNA family]Yan He Guo
Xin Yuan Institute of Medicine and Biotechnology, College of Life Science, Zhejiang Sci Tech University, Hangzhou 310018, China
Yi Chuan 30:28-34. 2008..It is well believed that the more intensive research on piRNA will throw light on the delicate mechanisms of gene expression modulation for eukaryotic species... - Nuclear α1-antichymotrypsin promotes chromatin condensation and inhibits proliferation of human hepatocellular carcinoma cellsMonica Santamaria
Division of Hepatology and Gene Therapy, Centro de Investigación Médica Aplicada CIMA, University of Navarra, Pamplona, Spain
Gastroenterology 144:818-828.e4. 2013..Expression of α1-ACT is down-regulated in human hepatocellular carcinoma (HCC) tissues and cells; we examined its roles in liver regeneration and HCC proliferation... - Effective gene-virotherapy for complete eradication of tumor mediated by the combination of hTRAIL (TNFSF10) and plasminogen k5Xin Yuan Liu
Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China
Mol Ther 11:531-41. 2005..Therefore, targeting dual gene-virotherapy may be one of the best strategies for cancer therapy if two suitable genes are chosen... - Immunotherapy of murine hepatocellular carcinoma by alpha-fetoprotein DNA vaccination combined with adenovirus-mediated chemokine and cytokine expressionMaría Matilde Bartolomé Rodríguez
Department of Medicine II, University Hospital Freiburg, 79106 Freiburg, Germany
Hum Gene Ther 19:753-9. 2008..This effect may be mediated by attraction of activated effector cells to the tumor tissue... - Adjuvant interleukin-12 gene therapy for the management of colorectal liver metastasesArnaud Alves
Laboratory of Biology and Therapeutic of Immune Diseases, University Pierre and Marie Curie, CNRS UMR7087, , Paris, France
Cancer Gene Ther 11:782-9. 2004..Altogether, our results suggest that IL-12 adjuvant gene therapy could improve the management of patients with either resectable or unresectable LM... - Induction of murine liver damage by overexpression of CD40 ligand provides an experimental model to study fulminant hepatic failureVolker Schmitz
Medizinische Klinik und Poliklinik I, Universitat Bonn, Bonn, Germany
Hepatology 44:430-9. 2006..This model suggests involvement of the CD40-CD40L system in FHF and might have important implications for future pathophysiological studies of this condition... - Use of adenoviruses encoding CD40L or IL-2 against B cell lymphomaEl Kahina Meziane
CRUK Immunology Group, Paterson Institute for Cancer Research, Christie Hospital NHS Trust, Manchester, United Kingdom
Int J Cancer 111:910-20. 2004..0001). Our study strongly supports the use of Ad-CD40L and Ad-IL-2 combination therapy for the treatment of patients with B cell lymphoma... - Gene therapy of liver diseasesJesus Prieto
Department of Internal Medicine, Clinica Universitaria de Navarra, Avda. Pio XII 36, 31008 Pamplona, Spain
Expert Opin Biol Ther 4:1073-91. 2004..Recent progress in vector technology and imaging techniques, allowing in vivo assessment of gene expression, will facilitate the development of clinical applications of gene therapy... - Combination of Targeting Gene-ViroTherapy with 5-FU enhances antitumor efficacy in malignant colorectal carcinomaSongbo Qiu
Institute of Molecular Virology, College of Life Science, Wuhan University, Wuhan 430072, China
J Interferon Cytokine Res 24:219-30. 2004..Furthermore, no detectable hepatoxicity was found by serum enzyme level analysis. These results suggest that ZD55-hTRAIL alone or in combination with 5-FU may have potential clinical implications... - An oncolytic adenoviral vector of Smac increases antitumor activity of TRAIL against HCC in human cells and in miceZifei Pei
Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China
Hepatology 39:1371-81. 2004..The combination of Smac and TRAIL delivered by way of the oncolytic adenoviral vector would provide a useful strategy for therapy of HCC and might also be applied to other IAPs abundant in cancers... - A novel oncolytic adenovirus targeting to telomerase activity in tumor cells with potentWeiguo Zou
Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 320 Yue-Yang Road, Shanghai 200031, China
Oncogene 23:457-64. 2004..TERT was targeted by the telomerase activity in cancer cells and has potent antitumoral efficacy in vivo, and since telomerase activity is a wide-ranged tumor marker, Ad.TERT could be a powerful therapeutic agent for a variety of cancers... - Suppression of tumor growth by oncolytic adenovirus-mediated delivery of an antiangiogenic gene, soluble Flt-1Zilai Zhang
Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China
Mol Ther 11:553-62. 2005..These results indicate that ZD55-sflt-1, combining the advantages of oncolytic adenovirus and antiangiogenic gene therapy, is a powerful agent for human tumor treatment... - Effective antitumour mono- and combination therapy by gene delivery of angiostatin-like molecule and interleukin-12 in a murine hepatoma modelVolker Schmitz
Department of Internal Medicine I, University Hospital Bonn, Bonn, Germany
Int J Colorectal Dis 20:494-501. 2005..We applied an experimental approach employing two recombinant adenoviral vectors (Ad) that express interleukin-12 (IL-12) and angiostatin-like molecule (K1-3) respectively to a subcutaneous hepatoma model in mice... - Effective angiostatic treatment in a murine metastatic and orthotopic hepatoma modelEsther Raskopf
Department of Internal Medicine I, University Hospital Bonn, Germany
Hepatology 41:1233-40. 2005..The data support the value of VEGF blockade as an effective target for HCC treatment... - Suppression of colorectal tumor growth by regulated survivin targetingBinghua Li
Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 320 Yueyang Road, Shanghai 200031, China
J Mol Med (Berl) 84:1077-86. 2006..Synergized with the chemotherapeutic drug cisplatin, regulated surDN expression completely suppressed tumor growth. These results indicated that this modified RU486-regulated system could be useful in cancer-targeting therapy... - SHP-2 phosphatase negatively regulates the TRIF adaptor protein-dependent type I interferon and proinflammatory cytokine productionHuazhang An
Institute of Immunology and National Key Laboratory of Medical Immunology, Second Military Medical University, Shanghai 200433, People s Republic of China
Immunity 25:919-28. 2006..These results demonstrate that SHP-2 specifically negatively regulate TRIF-mediated gene expression in TLR signaling, partially through inhibiting TBK1-activated signal transduction... - A survivin-mediated oncolytic adenovirus induces non-apoptotic cell death in lung cancer cells and shows antitumoral potential in vivoBinghua Li
Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China
J Gene Med 8:1232-42. 2006..SP/E1A could be a potent therapeutic agent for cancer gene therapy. The investigation of the mechanisms of oncolytic virus-induced cell death in this work will shed light on the construction of more powerful vectors for cancer therapy... - TLR agonists promote ERK-mediated preferential IL-10 production of regulatory dendritic cells (diffDCs), leading to NK-cell activationCheng Qian
Institute of Immunology and National Key Laboratory of Medical Immunology, Second Military Medical University, 800 Xiangyin Rd, Shanghai, 200433, People s Republic of China
Blood 108:2307-15. 2006..Our results illuminate signal pathways for the unique cytokine profile of diffDCs, and diffDCs can exert their regulatory function even after inflammatory stimuli, thus reflecting one way for strict regulation of immune response... - Treatment of metastatic colorectal carcinomas by systemic inhibition of vascular endothelial growth factor signaling in miceVolker Schmitz
Medizinische Klinik I, Sigmund Freud Str 25, Bonn 53105, Germany
World J Gastroenterol 11:4332-6. 2005..Here, we tested a recombinant adenovirus, AdsFlt1-3, that encodes an antagonistically acting fragment of the VEGF receptor 1 (Flt-1), for systemic antitumor effects in pre-established subcutaneous CRC tumors in mice... - Potent antitumor activity of oncolytic adenovirus expressing mda-7/IL-24 for colorectal cancerLili Zhao
Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China
Hum Gene Ther 16:845-58. 2005..These data indicated that oncolytic adenovirus expressing IL-24 could exert potential antitumor activity and offer a novel approach to cancer therapy... - Complete elimination of colorectal tumor xenograft by combined manganese superoxide dismutase with tumor necrosis factor-related apoptosis-inducing ligand gene virotherapyYanhong Zhang
Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, China
Cancer Res 66:4291-8. 2006..In conclusion, our dual gene virotherapy completely eliminated colorectal tumor xenografts via enhanced apoptosis, and this novel strategy points toward a new direction of cancer treatment... - New strategies to enhance gene therapy efficiencyCheng Qian
Gastroenterology 123:639-42. 2002 - Establishment of an orthotopic tumour model for hepatocellular carcinoma and non-invasive in vivo tumour imaging by high resolution ultrasound in miceVolker Schmitz
Department of Internal Medicine I, University Hospital Bonn, Bonn, Germany
J Hepatol 40:787-91. 2004..In this study we established an orthotopic tumour model for hepatocellular carcinoma and evaluated a non-invasive high resolution ultrasound technique for diagnosis and follow-up of intrahepatic HCC... - Genome assembly comparison identifies structural variants in the human genomeRazi Khaja
Program in Genetics and Genomic Biology, The Hospital for Sick Children and Department of Molecular and Medical Genetics, University of Toronto and The Centre for Applied Genomics, MaRS Centre, Toronto, Ontario, M5G 1L7, Canada
Nat Genet 38:1413-8. 2006..Our results uncover substantial undescribed variation in humans, highlighting the need for comprehensive annotation strategies to fully interpret genome scanning and personalized sequencing projects... - Src homology 2 domain-containing inositol-5-phosphatase 1 (SHIP1) negatively regulates TLR4-mediated LPS response primarily through a phosphatase activity- and PI-3K-independent mechanismHuazhang An
Institute of Immunology, Second Military Medical University, Shanghai, People s Republic of China
Blood 105:4685-92. 2005.... - TLR agonists induce regulatory dendritic cells to recruit Th1 cells via preferential IP-10 secretion and inhibit Th1 proliferationCheng Qian
Institute of Immunology and National Key Laboratory of Medical Immunology, Second Military Medical University, 800 Xiangyin Road, Shanghai 200433, People s Republic of China
Blood 109:3308-15. 2007..Our results demonstrate a new manner for regulatory DCs to down-regulate T-cell response by preferential IP-10 production and inhibition of recruited Th1 cell proliferation... - Induction of a high population of neural stem cells with anterior neuroectoderm characters from epiblast-like P19 embryonic carcinoma cellsCaihong Xia
Laboratory of Molecular Cell Biology, Key Laboratory of Stem Cell Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China
Differentiation 75:912-27. 2007..This method will provide an in vitro system to dissect the molecular mechanisms involved in neural induction of early mouse embryos... - Increased granulysin expression in peripheral blood cells of patients with primary biliary cirrhosis and its clinical implicationsCheng Qian
Clinical Immunology Center of PLA, Changzheng Hospital, Second Military Medical University, Fengyang Road 415, Shanghai 200003, China
J Clin Immunol 28:520-7. 2008..Granulysin is a cytotoxic molecule involved in cellular immune reactions... - A promising technique for transplantation of bone marrow-derived endothelial progenitor cells into rat heartCheng Qian
Department of Clinical Pharmacology, University Hospital of Groningen, The Netherlands
Cardiovasc Pathol 16:127-35. 2007..To investigate the feasibility of intracoronary application of endothelial progenitor cells and the subsequent distribution within the heart...