Cheng Qian

Summary

Affiliation: University of Navarra
Country: Spain

Publications

  1. doi request reprint Targeting toll-like receptor 9 with CpG oligodeoxynucleotides enhances anti-tumor responses of peripheral blood mononuclear cells from human lung cancer patients
    Tao Ren
    Department of Respiratory Medicine, East Hospital, Tongji University, Shanghai, China
    Cancer Invest 26:448-55. 2008
  2. doi request reprint Blockade of Wnt signaling inhibits angiogenesis and tumor growth in hepatocellular carcinoma
    Jie Hu
    Division of Gene Therapy and Hepatology, Center for Applied Medical Research, University of Navarra, Pamplona, Spain
    Cancer Res 69:6951-9. 2009
  3. ncbi request reprint Therapy of cancer by cytokines mediated by gene therapy approach
    Cheng Qian
    Xinyuan Institute of Medicine and Biotechnology, School of Life Sciences, Zhejiang Sci Tech University, Hangzhou, China
    Cell Res 16:182-8. 2006
  4. ncbi request reprint Gene therapy of cancer: induction of anti-tumor immunity
    Cheng Qian
    Division of Hepatology and Gene Therapy, Medical School, Fundacion para la Investigacion Medica Aplicada, University of Navarra, Pamplona, Spain
    Cell Mol Immunol 1:105-11. 2004
  5. ncbi request reprint Intratumoral injection of dendritic cells engineered to secrete interleukin-12 by recombinant adenovirus in patients with metastatic gastrointestinal carcinomas
    Guillermo Mazzolini
    Division of Hepatology and Gene Therapy, Department of Radiology, Clinica Universitaria School of Medicine, University of Navarra, C Irunlarrea, S N, 31008 Pamplona, Spain
    J Clin Oncol 23:999-1010. 2005
  6. ncbi request reprint Intrahepatic injection of adenovirus reduces inflammation and increases gene transfer and therapeutic effect in mice
    Julien Crettaz
    Division of Gene Therapy and Hepatology, Center for Applied Medical Research CIMA, University of Navarra, Pamplona, Spain
    Hepatology 44:623-32. 2006
  7. doi request reprint Treatment of cancer with a novel dual-targeted conditionally replicative adenovirus armed with mda-7/IL-24 gene
    Jingjing Luo
    Institute of Medicine and Biotechnology, School of Life Sciences, Zhejiang Sci Tech University, Hangzhou, Zhejiang, China
    Clin Cancer Res 14:2450-7. 2008
  8. ncbi request reprint Optimization of the Tet-on system to regulate interleukin 12 expression in the liver for the treatment of hepatic tumors
    Maider Zabala
    Division of Hepatology and Gene Therapy, School of Medicine, Fundación para la Investigación Médica Aplicada FIMA, University of Navarra, Pamplona, Spain
    Cancer Res 64:2799-804. 2004
  9. ncbi request reprint Prolonged and inducible transgene expression in the liver using gutless adenovirus: a potential therapy for liver cancer
    Lin Wang
    Faculty of Medicine, University of Navarra, Pamplona, Spain
    Gastroenterology 126:278-89. 2004
  10. ncbi request reprint Increased efficacy and safety in the treatment of experimental liver cancer with a novel adenovirus-alphavirus hybrid vector
    Min Guan
    Division of Hepatology and Gene Therapy, School of Medicine, Centro de Investigación Médica Aplicada, University of Navarra, 31008 Pamplona, Spain
    Cancer Res 66:1620-9. 2006

Collaborators

Detail Information

Publications68

  1. doi request reprint Targeting toll-like receptor 9 with CpG oligodeoxynucleotides enhances anti-tumor responses of peripheral blood mononuclear cells from human lung cancer patients
    Tao Ren
    Department of Respiratory Medicine, East Hospital, Tongji University, Shanghai, China
    Cancer Invest 26:448-55. 2008
    ..Our findings suggest that the CpG-ODN is promising as a preventive and therapeutic anti-tumor measure against pulmonary carcinoma...
  2. doi request reprint Blockade of Wnt signaling inhibits angiogenesis and tumor growth in hepatocellular carcinoma
    Jie Hu
    Division of Gene Therapy and Hepatology, Center for Applied Medical Research, University of Navarra, Pamplona, Spain
    Cancer Res 69:6951-9. 2009
    ..Our data indicate that Wnt antagonists WIF1-Fc and sFRP1-Fc inhibit Wnt signaling and exert potent antitumor activity by increasing the apoptosis rate in tumor cells and by impairing tumor vascularization...
  3. ncbi request reprint Therapy of cancer by cytokines mediated by gene therapy approach
    Cheng Qian
    Xinyuan Institute of Medicine and Biotechnology, School of Life Sciences, Zhejiang Sci Tech University, Hangzhou, China
    Cell Res 16:182-8. 2006
    ..The combination of cytopathic effect by oncolytic adenovirus and biological effect of transgene would exert strong antitumor activity. These new types of vectors may provide a potent and safe tool for cancer gene therapy...
  4. ncbi request reprint Gene therapy of cancer: induction of anti-tumor immunity
    Cheng Qian
    Division of Hepatology and Gene Therapy, Medical School, Fundacion para la Investigacion Medica Aplicada, University of Navarra, Pamplona, Spain
    Cell Mol Immunol 1:105-11. 2004
    ....
  5. ncbi request reprint Intratumoral injection of dendritic cells engineered to secrete interleukin-12 by recombinant adenovirus in patients with metastatic gastrointestinal carcinomas
    Guillermo Mazzolini
    Division of Hepatology and Gene Therapy, Department of Radiology, Clinica Universitaria School of Medicine, University of Navarra, C Irunlarrea, S N, 31008 Pamplona, Spain
    J Clin Oncol 23:999-1010. 2005
    ..Secondarily, we have evaluated biologic effects and antitumoral activity...
  6. ncbi request reprint Intrahepatic injection of adenovirus reduces inflammation and increases gene transfer and therapeutic effect in mice
    Julien Crettaz
    Division of Gene Therapy and Hepatology, Center for Applied Medical Research CIMA, University of Navarra, Pamplona, Spain
    Hepatology 44:623-32. 2006
    ..In conclusion, IH injection of adenovirus represents a safe and efficient administration route for clinical applications of gene therapy targeting the liver...
  7. doi request reprint Treatment of cancer with a novel dual-targeted conditionally replicative adenovirus armed with mda-7/IL-24 gene
    Jingjing Luo
    Institute of Medicine and Biotechnology, School of Life Sciences, Zhejiang Sci Tech University, Hangzhou, Zhejiang, China
    Clin Cancer Res 14:2450-7. 2008
    ..However, better specificity and mode of transgene expression are required to improve the efficacy and safety if this vector is applied for clinical application...
  8. ncbi request reprint Optimization of the Tet-on system to regulate interleukin 12 expression in the liver for the treatment of hepatic tumors
    Maider Zabala
    Division of Hepatology and Gene Therapy, School of Medicine, Fundación para la Investigación Médica Aplicada FIMA, University of Navarra, Pamplona, Spain
    Cancer Res 64:2799-804. 2004
    ..These data demonstrate the potential of a naked DNA gene therapy strategy to achieve tight control of IL-12 within the liver for the treatment of cancer...
  9. ncbi request reprint Prolonged and inducible transgene expression in the liver using gutless adenovirus: a potential therapy for liver cancer
    Lin Wang
    Faculty of Medicine, University of Navarra, Pamplona, Spain
    Gastroenterology 126:278-89. 2004
    ..Gene therapy of liver diseases would benefit from systems allowing prolonged, regulable, and tissue-specific transgene expression. We attempted to produce a vector fulfilling these requirements...
  10. ncbi request reprint Increased efficacy and safety in the treatment of experimental liver cancer with a novel adenovirus-alphavirus hybrid vector
    Min Guan
    Division of Hepatology and Gene Therapy, School of Medicine, Centro de Investigación Médica Aplicada, University of Navarra, 31008 Pamplona, Spain
    Cancer Res 66:1620-9. 2006
    ..This new type of hybrid vectors may provide a potent and safe tool for cancer gene therapy...
  11. ncbi request reprint Biologic therapy of liver tumors
    Jesus Prieto
    Division of Hepatology and Gene Therapy, Fundación para la Investigación Médica Aplicada FIMA, University of Navarra, Avenida Pio XII s n, 31080 Pamplona, Spain
    Surg Clin North Am 84:673-96. 2004
    ..Combination of biological modifiers, gene therapy, and cell therapy will hopefully provide efficient means to combat inoperable neoplasms in a not-very-distant future...
  12. ncbi request reprint Positron emission tomography imaging of adenoviral-mediated transgene expression in liver cancer patients
    Ivan Penuelas
    Department of Nuclear Medicine, Clinica Universitaria de Navarro, Pamplona, Spain
    Gastroenterology 128:1787-95. 2005
    ....
  13. ncbi request reprint The oncolytic adenovirus targeting to TERT and RB pathway induced specific and potent anti-tumor efficacy in vitro and in vivo for hepatocellular carcinoma
    Wei Zhang
    Xinyuan Institute of Medicine and Biotechnology, School of Life Sciences, Zhejiang Sci Tech University, Hangzhou, Zhejiang, China
    Cancer Biol Ther 6:1726-32. 2007
    ..Oncolytic viruses have been used as targeting therapy for different malignancies. In study, we have engineered oncolytic adenovirus to target both of TERT and RB pathways to achieve strict tumor specificity...
  14. doi request reprint Generation of full-length functional antibody against preS2 of hepatitis B virus in hepatic cells in vitro from bicistrons mediated by gutless adenovirus
    Yuexiang Yin
    Xinyuan Institute of Medicine and Biotechnology, School of Life Sciences, Zhejiang Sci Tech University, Hangzhou, Zhejiang, China
    BioDrugs 23:391-7. 2009
    ..However, for the polymeric structure of full-length mAbs, it is important to design an optimal gene transfer system for mAb generation...
  15. ncbi request reprint Synergistic antitumor activity of XIAP-shRNA and TRAIL expressed by oncolytic adenoviruses in experimental HCC
    Qiuwei Pan
    Xinyuan Institute of Medicine and Biotechnology, School of Life Science, Zhejiang Sci Tech University, Hangzhou, China
    Acta Oncol 47:135-44. 2008
    ..This pilot study offers a promise of using oncolytic adenovirus to deliver siRNA targeting overexpressed oncogenes and a novel strategy for cancer therapy by regulating the equilibrium between the proapoptotic and antiapoptotic factors...
  16. ncbi request reprint Expression of miR-122 mediated by adenoviral vector induces apoptosis and cell cycle arrest of cancer cells
    Leina Ma
    Xinyuan Institute of Medicine and Biotechnology, School of Life Sciences, Zhejiang Sci Tech University, Hangzhou, Zhejiang, China
    Cancer Biol Ther 9:554-61. 2010
    ..In this study, we presented a novel strategy for cancer therapy based on gene transfer of miR-122 by adenoviral vector...
  17. ncbi request reprint Enhanced sensitivity of hepatocellular carcinoma cells to chemotherapy with a Smac-armed oncolytic adenovirus
    Qiu wei Pan
    Xin Yuan Institute of Medicine and Biotechnology, Life Science College, Zhejiang Sci Tech University, Hangzhou 310018, China
    Acta Pharmacol Sin 28:1996-2004. 2007
    ..The aim of the present study was to further improve the therapeutic effects for human hepatocellular carcinoma (HCC) and reduce the damage in normal cells using a novel chemo-gene-virotherapeutic strategy...
  18. doi request reprint Influence of the chitosan nature on the transfection efficacy of DNA-loaded nanoparticles after hydrodynamic administration in mice
    Miguel N Centelles
    Centro Galenico, Departamento Farmacia y Tecnología Farmacéutica, University of Navarra, Irunlarrea 1, 31080 Pamplona, Spain
    J Microencapsul 27:460-9. 2010
    ....
  19. ncbi request reprint Gene therapy of cancer based on interleukin 12
    Bruno Sangro
    Liver Unit, Clinica Universitaria de Navarra, and the Division of Hepatology and Gene Therapy, Centro de Investigación Médica Aplicada, Pamplona, Spain
    Curr Gene Ther 5:573-81. 2005
    ..New vectors that might achieve regulated, long-term production of this cytokine might have better results and merit clinical testing...
  20. doi request reprint Water-soluble andrographolide sulfonate exerts anti-sepsis action in mice through down-regulating p38 MAPK, STAT3 and NF-κB pathways
    Wenjie Guo
    State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, 22 Han Kou Road, Nanjing 210093, China
    Int Immunopharmacol 14:613-9. 2012
    ....
  21. ncbi request reprint Antitumoral activity of transferrin-lipoplexes carrying the IL-12 gene in the treatment of colon cancer
    Conchita Tros de Ilarduya
    Department of Pharmacy and Pharmaceutical Technology, School of Pharmacy, University of Navarra, Pamplona, Spain
    J Drug Target 14:527-35. 2006
    ..The vector has the advantages of ease of preparation and economy, in comparison with commercial transfection reagents, as well as, the possibility of a large scale production...
  22. ncbi request reprint Suppression of angiogenesis and tumor growth by adenoviral-mediated gene transfer of pigment epithelium-derived factor
    Lin Wang
    Division of Hepatology and Gene Therapy, Department of Medicine, Pamplona, Spain
    Mol Ther 8:72-9. 2003
    ..These data suggest that the antiangiogenic properties of PEDF can be exploited to inhibit the establishment of tumor neovasculature and reduce tumor growth...
  23. ncbi request reprint Transfer of suppressor of cytokine signaling 3 by an oncolytic adenovirus induces potential antitumor activities in hepatocellular carcinoma
    Qiang Cui
    Xinyuan Institute of Medicine and Biotechnology, School of Life Sciences, Zhejiang Sci Tech University, Hangzhou, China
    Hepatology 47:105-12. 2008
    ..Conclusion: This study suggests that transfer of SOCS3 by an oncolytic adenovirus represents a potent approach for cancer therapy...
  24. pmc Mitochondria-dependent apoptosis of con A-activated T lymphocytes induced by asiatic acid for preventing murine fulminant hepatitis
    Wenjie Guo
    State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, China
    PLoS ONE 7:e46018. 2012
    ..Taken together, our results demonstrated that the ability of asiatic acid to induce apoptosis of activated T cells and its potential use in the treatment of T-cell-mediated inflammatory diseases...
  25. ncbi request reprint Improving efficacy of interleukin-12-transfected dendritic cells injected into murine colon cancer with anti-CD137 monoclonal antibodies and alloantigens
    Iñigo Tirapu
    Gene Therapy Division, Fundacion para la Investigacion Medica Aplicada, University of Navarre, Irunlarrea s n 31008 Pamplona, Navarre, Spain
    Int J Cancer 110:51-60. 2004
    ..Supplementary Material for this article can be found on the International Journal of Cancer website at http://www.interscience.wiley.com/jpages/0020-7136/suppmat/index.html...
  26. doi request reprint Inhibition of Th1/Th17 responses via suppression of STAT1 and STAT3 activation contributes to the amelioration of murine experimental colitis by a natural flavonoid glucoside icariin
    Feifei Tao
    State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, China
    Biochem Pharmacol 85:798-807. 2013
    ..Taken together, these results indicate that icariin is a potential therapeutic agent for IBD...
  27. ncbi request reprint In vitro and in vivo comparative study of chimeric liver-specific promoters
    M Gabriela Kramer
    Division of Hepatology and Gene Therapy, Department of Internal Medicine, School of Medicine, University of Navarra, 31008 Pamplona, Spain
    Mol Ther 7:375-85. 2003
    ..We found that among the various chimeric constructs tested in this work, the alpha1-antitrypsin promoter alone or linked to the albumin or hepatitis B enhancers is the most potent in directing stable gene expression in liver cells...
  28. ncbi request reprint Human adenovirus replicates in immunocompetent models of pancreatic cancer in Syrian hamsters
    Sergia Bortolanza
    Gene Therapy Unit, Center for Applied Medical Research, University of Navarra, 31008 Pamplona, Spain
    Hum Gene Ther 18:681-90. 2007
    ..In conclusion, the Syrian hamster models described here offer the opportunity to evaluate the effect of oncolytic adenoviruses in an immunocompetent animal and may be a valuable tool in the preclinical evaluation of these agents...
  29. pmc New methodologies to characterize the effectiveness of the gene transfer mediated by DNA-chitosan nanoparticles
    Miguel N Centelles
    Centro Galenico, Departamento Farmacia y Tecnología Farmacéutica, University of Navarra, Pamplona, Spain
    Int J Nanomedicine 3:451-60. 2008
    ..This fact could be explained by the rapid physiological turn-over of enterocytes and by the ability of chitosan nanoparticles to control the DNA release...
  30. doi request reprint Metabolite profiling of astilbin in rat sera using UPLC/MS(E) and impact of its metabolites on immunosuppressive activity
    Jiayu Tang
    State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, Nanjing 210093, China
    J Chromatogr B Analyt Technol Biomed Life Sci 929:56-62. 2013
    ....
  31. ncbi request reprint [An efficient tool for the construction of multiple-cistronic vectors: FMDV 2A]
    Bi Sheng Liu
    Xinyuan Institute of Medicine and Biotechnology, School of Life Sciences, Zhejiang Sci Tech University, Hangzhou 310018, China
    Sheng Wu Gong Cheng Xue Bao 23:765-9. 2007
    ..In this article, the characteristics and cleavage activities of FMDV 2A will be elucidated,and we further outline its applications in cancer gene therapy...
  32. ncbi request reprint Liver failure caused by herpes simplex virus thymidine kinase plus ganciclovir therapy is associated with mitochondrial dysfunction and mitochondrial DNA depletion
    Maite Herraiz
    Division of Hepatology and Gene Therapy, University of Navarra, Medical School Pamplona, 31008 Pamplona, Spain
    Hum Gene Ther 14:463-72. 2003
    ..These data are relevant for the design of clinical trials using adenoviral vectors encoding HSV-tk...
  33. ncbi request reprint Synergistic induction of tumor cell death by combining cisplatin with an oncolytic adenovirus carrying TRAIL
    Qiuwei Pan
    Xin Yuan Institute of Medicine and Biotechnology, Life Science College, Zhejiang Sci Tech University, Hangzhou 310018, China
    Mol Cell Biochem 304:315-23. 2007
    ..Thus, a novel chemo-gene-virotherapeutic strategy for cancer therapy was proposed...
  34. ncbi request reprint Phase I trial of intratumoral injection of an adenovirus encoding interleukin-12 for advanced digestive tumors
    Bruno Sangro
    Liver Unit, Division of Gene Therapy, Department of Internal Medicine, Clinica Universitaria, University of Navarre, Ap 4209 Pamplona 31080, Spain
    J Clin Oncol 22:1389-97. 2004
    ..To evaluate the feasibility and safety of intratumoral injection of an adenoviral vector encoding human interleukin-12 genes (Ad.IL-12) and secondarily, its biologic effect for the treatment of advanced digestive tumors...
  35. ncbi request reprint Anti-ICAM-2 monoclonal antibody synergizes with intratumor gene transfer of interleukin-12 inhibiting activation-induced T-cell death
    Ignacio Melero
    Centro de Investigación Médica Aplicada CIMA, Facultad de Medicina, Gene Therapy Unit, Universidad de Navarra, 31008 Pamplona, Spain
    Clin Cancer Res 9:3546-54. 2003
    ..We sought to design combined therapy strategies with AdCMVIL-12 plus anti-ICAM-2 mAbs and to identify their mechanism of action...
  36. doi request reprint Nuclear α1-antichymotrypsin promotes chromatin condensation and inhibits proliferation of human hepatocellular carcinoma cells
    Monica Santamaria
    Division of Hepatology and Gene Therapy, Centro de Investigación Médica Aplicada CIMA, University of Navarra, Pamplona, Spain
    Gastroenterology 144:818-828.e4. 2013
    ..Expression of α1-ACT is down-regulated in human hepatocellular carcinoma (HCC) tissues and cells; we examined its roles in liver regeneration and HCC proliferation...
  37. ncbi request reprint [miR-34s--a tumor suppression protein p53 highly related microRNA]
    Wen Jia Lou
    Xinyuan Institute of Medicine and Biotechnology, College of Life Science, Zhejiang Sci Tech University, Hangzhou 310018, China
    Yi Chuan 32:423-30. 2010
    ..This paper summarizes the latest advances of p53 highly related miR-34 families in oncogenesis and treatment...
  38. ncbi request reprint Gene therapy of hepatocellular carcinoma and gastrointestinal tumors
    Bruno Sangro
    Gene Therapy Unit, Department of Internal Medicine, Clinica Universitaria, Universidad de Navarra, Pamplona, Spain
    Ann N Y Acad Sci 963:6-12. 2002
    ..In summary, a variety of gene therapy strategies have been effective against animal models of gastrointestinal tumors. Clinical trials should determine whether human patients can be treated safely and effectively by such strategies...
  39. pmc A novel chromone derivative with anti-inflammatory property via inhibition of ROS-dependent activation of TRAF6-ASK1-p38 pathway
    Hailiang Liu
    State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, Nanjing, China
    PLoS ONE 7:e37168. 2012
    ..Blockade of the upstream events required for p38 MAPK action by DCO-6 may provide a new therapeutic option in the treatment of inflammatory diseases...
  40. ncbi request reprint [piRNA: a novel member of small RNA family]
    Yan He Guo
    Xin Yuan Institute of Medicine and Biotechnology, College of Life Science, Zhejiang Sci Tech University, Hangzhou 310018, China
    Yi Chuan 30:28-34. 2008
    ..It is well believed that the more intensive research on piRNA will throw light on the delicate mechanisms of gene expression modulation for eukaryotic species...
  41. doi request reprint Histone deacetylase 3 participates in self-renewal of liver cancer stem cells through histone modification
    Chungang Liu
    Institute of Pathology and Southwest Cancer Center, Southwest Hospital, Third Military Medical University, Chongqing, China Department of Pathology, School of Medicine, Zhejiang University, Hangzhou, China
    Cancer Lett 339:60-9. 2013
    ..HDAC inhibitors could render liver CSCs sensitive to sorafenib. Taken together, our data suggest that HDAC3 plays a critical role in regulating self-renewal of liver CSCs. ..
  42. doi request reprint Immunotherapy of murine hepatocellular carcinoma by alpha-fetoprotein DNA vaccination combined with adenovirus-mediated chemokine and cytokine expression
    María Matilde Bartolomé Rodríguez
    Department of Medicine II, University Hospital Freiburg, 79106 Freiburg, Germany
    Hum Gene Ther 19:753-9. 2008
    ..This effect may be mediated by attraction of activated effector cells to the tumor tissue...
  43. ncbi request reprint An oncolytic adenoviral vector of Smac increases antitumor activity of TRAIL against HCC in human cells and in mice
    Zifei Pei
    Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China
    Hepatology 39:1371-81. 2004
    ..The combination of Smac and TRAIL delivered by way of the oncolytic adenoviral vector would provide a useful strategy for therapy of HCC and might also be applied to other IAPs abundant in cancers...
  44. ncbi request reprint Effective gene-virotherapy for complete eradication of tumor mediated by the combination of hTRAIL (TNFSF10) and plasminogen k5
    Xin Yuan Liu
    Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China
    Mol Ther 11:531-41. 2005
    ..Therefore, targeting dual gene-virotherapy may be one of the best strategies for cancer therapy if two suitable genes are chosen...
  45. ncbi request reprint Combination of Targeting Gene-ViroTherapy with 5-FU enhances antitumor efficacy in malignant colorectal carcinoma
    Songbo Qiu
    Institute of Molecular Virology, College of Life Science, Wuhan University, Wuhan 430072, China
    J Interferon Cytokine Res 24:219-30. 2004
    ..Furthermore, no detectable hepatoxicity was found by serum enzyme level analysis. These results suggest that ZD55-hTRAIL alone or in combination with 5-FU may have potential clinical implications...
  46. ncbi request reprint Adjuvant interleukin-12 gene therapy for the management of colorectal liver metastases
    Arnaud Alves
    Laboratory of Biology and Therapeutic of Immune Diseases, University Pierre and Marie Curie, CNRS UMR7087, Pitie Salpetriere Hospital, Paris, France
    Cancer Gene Ther 11:782-9. 2004
    ..Altogether, our results suggest that IL-12 adjuvant gene therapy could improve the management of patients with either resectable or unresectable LM...
  47. ncbi request reprint Use of adenoviruses encoding CD40L or IL-2 against B cell lymphoma
    El Kahina Meziane
    CRUK Immunology Group, Paterson Institute for Cancer Research, Christie Hospital NHS Trust, Manchester, United Kingdom
    Int J Cancer 111:910-20. 2004
    ..0001). Our study strongly supports the use of Ad-CD40L and Ad-IL-2 combination therapy for the treatment of patients with B cell lymphoma...
  48. ncbi request reprint A survivin-mediated oncolytic adenovirus induces non-apoptotic cell death in lung cancer cells and shows antitumoral potential in vivo
    Binghua Li
    Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China
    J Gene Med 8:1232-42. 2006
    ..It has been reported that activity of the survivin promoter is tumor-specific, which makes the survivin promoter a good candidate to construct oncolytic viral vectors...
  49. ncbi request reprint Gene therapy of liver diseases
    Jesus Prieto
    Department of Internal Medicine, Clinica Universitaria de Navarra, Avda Pio XII 36, 31008 Pamplona, Spain
    Expert Opin Biol Ther 4:1073-91. 2004
    ..Recent progress in vector technology and imaging techniques, allowing in vivo assessment of gene expression, will facilitate the development of clinical applications of gene therapy...
  50. ncbi request reprint Suppression of tumor growth by oncolytic adenovirus-mediated delivery of an antiangiogenic gene, soluble Flt-1
    Zilai Zhang
    Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China
    Mol Ther 11:553-62. 2005
    ..These results indicate that ZD55-sflt-1, combining the advantages of oncolytic adenovirus and antiangiogenic gene therapy, is a powerful agent for human tumor treatment...
  51. ncbi request reprint Effective antitumour mono- and combination therapy by gene delivery of angiostatin-like molecule and interleukin-12 in a murine hepatoma model
    Volker Schmitz
    Department of Internal Medicine I, University Hospital Bonn, Bonn, Germany
    Int J Colorectal Dis 20:494-501. 2005
    ..We applied an experimental approach employing two recombinant adenoviral vectors (Ad) that express interleukin-12 (IL-12) and angiostatin-like molecule (K1-3) respectively to a subcutaneous hepatoma model in mice...
  52. ncbi request reprint SHP-2 phosphatase negatively regulates the TRIF adaptor protein-dependent type I interferon and proinflammatory cytokine production
    Huazhang An
    Institute of Immunology and National Key Laboratory of Medical Immunology, Second Military Medical University, Shanghai 200433, People s Republic of China
    Immunity 25:919-28. 2006
    ..These results demonstrate that SHP-2 specifically negatively regulate TRIF-mediated gene expression in TLR signaling, partially through inhibiting TBK1-activated signal transduction...
  53. ncbi request reprint A novel oncolytic adenovirus targeting to telomerase activity in tumor cells with potent
    Weiguo Zou
    Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 320 Yue Yang Road, Shanghai 200031, China
    Oncogene 23:457-64. 2004
    ..TERT was targeted by the telomerase activity in cancer cells and has potent antitumoral efficacy in vivo, and since telomerase activity is a wide-ranged tumor marker, Ad.TERT could be a powerful therapeutic agent for a variety of cancers...
  54. ncbi request reprint Induction of murine liver damage by overexpression of CD40 ligand provides an experimental model to study fulminant hepatic failure
    Volker Schmitz
    Medizinische Klinik und Poliklinik I, Universitat Bonn, Bonn, Germany
    Hepatology 44:430-9. 2006
    ..This model suggests involvement of the CD40-CD40L system in FHF and might have important implications for future pathophysiological studies of this condition...
  55. ncbi request reprint TLR agonists promote ERK-mediated preferential IL-10 production of regulatory dendritic cells (diffDCs), leading to NK-cell activation
    Cheng Qian
    Institute of Immunology and National Key Laboratory of Medical Immunology, Second Military Medical University, 800 Xiangyin Rd, Shanghai, 200433, People s Republic of China
    Blood 108:2307-15. 2006
    ..Our results illuminate signal pathways for the unique cytokine profile of diffDCs, and diffDCs can exert their regulatory function even after inflammatory stimuli, thus reflecting one way for strict regulation of immune response...
  56. ncbi request reprint Complete elimination of colorectal tumor xenograft by combined manganese superoxide dismutase with tumor necrosis factor-related apoptosis-inducing ligand gene virotherapy
    Yanhong Zhang
    Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, China
    Cancer Res 66:4291-8. 2006
    ..In conclusion, our dual gene virotherapy completely eliminated colorectal tumor xenografts via enhanced apoptosis, and this novel strategy points toward a new direction of cancer treatment...
  57. ncbi request reprint Treatment of metastatic colorectal carcinomas by systemic inhibition of vascular endothelial growth factor signaling in mice
    Volker Schmitz
    Medizinische Klinik I, Sigmund Freud Str 25, Bonn 53105, Germany
    World J Gastroenterol 11:4332-6. 2005
    ..Here, we tested a recombinant adenovirus, AdsFlt1-3, that encodes an antagonistically acting fragment of the VEGF receptor 1 (Flt-1), for systemic antitumor effects in pre-established subcutaneous CRC tumors in mice...
  58. ncbi request reprint Potent antitumor activity of oncolytic adenovirus expressing mda-7/IL-24 for colorectal cancer
    Lili Zhao
    Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China
    Hum Gene Ther 16:845-58. 2005
    ..These data indicated that oncolytic adenovirus expressing IL-24 could exert potential antitumor activity and offer a novel approach to cancer therapy...
  59. ncbi request reprint Effective angiostatic treatment in a murine metastatic and orthotopic hepatoma model
    Esther Raskopf
    Department of Internal Medicine I, University Hospital Bonn, Germany
    Hepatology 41:1233-40. 2005
    ..The data support the value of VEGF blockade as an effective target for HCC treatment...
  60. ncbi request reprint Suppression of colorectal tumor growth by regulated survivin targeting
    Binghua Li
    Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 320 Yueyang Road, Shanghai 200031, China
    J Mol Med (Berl) 84:1077-86. 2006
    ..Synergized with the chemotherapeutic drug cisplatin, regulated surDN expression completely suppressed tumor growth. These results indicated that this modified RU486-regulated system could be useful in cancer-targeting therapy...
  61. ncbi request reprint Establishment of an orthotopic tumour model for hepatocellular carcinoma and non-invasive in vivo tumour imaging by high resolution ultrasound in mice
    Volker Schmitz
    Department of Internal Medicine I, University Hospital Bonn, Bonn, Germany
    J Hepatol 40:787-91. 2004
    ..In this study we established an orthotopic tumour model for hepatocellular carcinoma and evaluated a non-invasive high resolution ultrasound technique for diagnosis and follow-up of intrahepatic HCC...
  62. ncbi request reprint New strategies to enhance gene therapy efficiency
    Cheng Qian
    Gastroenterology 123:639-42. 2002
  63. ncbi request reprint Src homology 2 domain-containing inositol-5-phosphatase 1 (SHIP1) negatively regulates TLR4-mediated LPS response primarily through a phosphatase activity- and PI-3K-independent mechanism
    Huazhang An
    Institute of Immunology, Second Military Medical University, Shanghai, People s Republic of China
    Blood 105:4685-92. 2005
    ....
  64. doi request reprint Increased granulysin expression in peripheral blood cells of patients with primary biliary cirrhosis and its clinical implications
    Cheng Qian
    Clinical Immunology Center of PLA, Changzheng Hospital, Second Military Medical University, Fengyang Road 415, Shanghai 200003, China
    J Clin Immunol 28:520-7. 2008
    ..Granulysin is a cytotoxic molecule involved in cellular immune reactions...
  65. pmc Genome assembly comparison identifies structural variants in the human genome
    Razi Khaja
    Program in Genetics and Genomic Biology, The Hospital for Sick Children and Department of Molecular and Medical Genetics, University of Toronto and The Centre for Applied Genomics, MaRS Centre, Toronto, Ontario, M5G 1L7, Canada
    Nat Genet 38:1413-8. 2006
    ..Our results uncover substantial undescribed variation in humans, highlighting the need for comprehensive annotation strategies to fully interpret genome scanning and personalized sequencing projects...
  66. ncbi request reprint Induction of a high population of neural stem cells with anterior neuroectoderm characters from epiblast-like P19 embryonic carcinoma cells
    Caihong Xia
    Laboratory of Molecular Cell Biology, Key Laboratory of Stem Cell Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China
    Differentiation 75:912-27. 2007
    ..This method will provide an in vitro system to dissect the molecular mechanisms involved in neural induction of early mouse embryos...
  67. ncbi request reprint A promising technique for transplantation of bone marrow-derived endothelial progenitor cells into rat heart
    Cheng Qian
    Department of Clinical Pharmacology, University Hospital of Groningen, The Netherlands
    Cardiovasc Pathol 16:127-35. 2007
    ..To investigate the feasibility of intracoronary application of endothelial progenitor cells and the subsequent distribution within the heart...
  68. ncbi request reprint TLR agonists induce regulatory dendritic cells to recruit Th1 cells via preferential IP-10 secretion and inhibit Th1 proliferation
    Cheng Qian
    Institute of Immunology and National Key Laboratory of Medical Immunology, Second Military Medical University, 800 Xiangyin Road, Shanghai 200433, People s Republic of China
    Blood 109:3308-15. 2007
    ..Our results demonstrate a new manner for regulatory DCs to down-regulate T-cell response by preferential IP-10 production and inhibition of recruited Th1 cell proliferation...