Research Topics

Maria P Portillo


Affiliation: University of the Basque Country
Country: Spain


  1. Gracia A, Miranda J, Fernández Quintela A, Eseberri I, Garcia Lacarte M, Milagro F, et al. Involvement of miR-539-5p in the inhibition of de novo lipogenesis induced by resveratrol in white adipose tissue. Food Funct. 2016;7:1680-8 pubmed publisher
    ..In conclusion, the up-regulation of miR-539-5p is involved in the inhibition of de novo lipogenesis induced by resveratrol in WAT. ..
  2. Lasa A, Simón E, Churruca I, Fernández Quintela A, Macarulla M, Martinez J, et al. Effects of trans-10,cis-12 CLA on liver size and fatty acid oxidation under energy restriction conditions in hamsters. Nutrition. 2011;27:116-121 pubmed publisher
    ..Consequently, this CLA isomer seems not to be a useful tool for inclusion in body weight loss strategies followed during obesity treatment. ..
  3. Miranda J, Lasa A, Aguirre L, Fernández Quintela A, Milton I, Portillo M. Potential application of non-flavonoid phenolics in diabetes: antiinflammatory effects. Curr Med Chem. 2015;22:112-31 pubmed
    ..Very little information has been reported with regard to human studies to date. Thus, new studies are needed to confirm if the beneficial effects observed in preclinical studies can apply to human beings. ..
  4. Aguirre L, Fernández Quintela A, Arias N, Portillo M. Resveratrol: anti-obesity mechanisms of action. Molecules. 2014;19:18632-55 pubmed publisher
    ..Thus, it increases mitochondriogenesis and consequently fatty acid oxidation in skeletal muscle and liver. This effect can also contribute to the body-fat lowering effect of this molecule. ..
  5. Arias N, Macarulla M, Aguirre L, Milton I, Portillo M. The combination of resveratrol and quercetin enhances the individual effects of these molecules on triacylglycerol metabolism in white adipose tissue. Eur J Nutr. 2016;55:341-8 pubmed publisher
  6. Gartziandia O, Lasa A, Pedraz J, Miranda J, Portillo M, Igartua M, et al. Preparation and Characterization of Resveratrol Loaded Pectin/Alginate Blend Gastro-Resistant Microparticles. Molecules. 2018;23: pubmed publisher
    ..In summary, the gastro-resistant microparticles developed could represent a suitable method of including resveratrol in dietary supplements and in functional foods used in obesity therapy. ..
  7. García Layana A, Ciufo G, Toledo E, Martínez González M, Corella D, Fitó M, et al. The Effect of a Mediterranean Diet on the Incidence of Cataract Surgery. Nutrients. 2017;9: pubmed publisher
    ..Further studies are necessary to investigate whether a MedDiet could have a preventive role in cataract surgery. ..
  8. Guo X, Tresserra Rimbau A, Estruch R, Martínez González M, Medina Remón A, Fitó M, et al. Polyphenol Levels Are Inversely Correlated with Body Weight and Obesity in an Elderly Population after 5 Years of Follow Up (The Randomised PREDIMED Study). Nutrients. 2017;9: pubmed publisher
    ..408; 95% CI: -0.788 to -0.028, p = 0.036) after adjustments for potential confounders. To conclude, a greater polyphenol intake may thus contribute to reducing body weight in elderly people at high cardiovascular risk. ..
  9. Escoté X, Gómez Zorita S, López Yoldi M, Milton Laskibar I, Fernández Quintela A, Martínez J, et al. Role of Omentin, Vaspin, Cardiotrophin-1, TWEAK and NOV/CCN3 in Obesity and Diabetes Development. Int J Mol Sci. 2017;18: pubmed publisher
    ..Finally, a strong correlation has been found between plasma NOV/CCN3 concentration and fat mass. This adipokine improves insulin actions. ..

More Information


  1. Mosqueda Solís A, Lasa A, Gómez Zorita S, Eseberri I, Picó C, Portillo M. Screening of potential anti-adipogenic effects of phenolic compounds showing different chemical structure in 3T3-L1 preadipocytes. Food Funct. 2017;8:3576-3586 pubmed publisher
    ..In conclusion, the most effective phenolic compounds are naringenin, hesperidin and quercetin. Differences were found in terms of effects on the expression of genes involved in adipogenesis among the analyzed compounds. ..