Cesar Picado

Summary

Affiliation: University of Barcelona
Country: Spain

Publications

  1. ncbi Cyclooxygenase-2 mRNA is downexpressed in nasal polyps from aspirin-sensitive asthmatics
    C Picado
    Servei de Pneumologia i Al lèrgia Respiratoria, Hospital Clinic, Departament de Medicina, Universitat de Barcelona, Spain
    Am J Respir Crit Care Med 160:291-6. 1999
  2. ncbi [Celecoxib in NSAID-induced cutaneous and respiratory adverse reactions]
    Antonio Valero
    Servicio de Neumología y Alergia Respiratoria Hospital Clínic Barcelona Spain
    Med Clin (Barc) 121:695-6. 2003
  3. ncbi COX-2 specific inhibitors in NSAID-intolerant patients
    P Picado
    Servei de Pneumologia i Respiratória, Hospital Clinic, Department de Medicina, Universitat de Barcelona, Barcelona, Spain
    Int J Immunopathol Pharmacol 16:11-6. 2003
  4. ncbi NSAID-sensitive patients tolerate rofecoxib
    A Valero
    Servei de Pneumologia i Allergia Respiratoria, Hospital Clinic, Villarroel, 17008036, Barcelona, Spain
    Allergy 57:1214-5. 2002
  5. ncbi Aspirin intolerance and nasal polyposis
    Cesar Picado
    Servei de Pneumologia, Hospital Clinic, Barcelona, Spain
    Curr Allergy Asthma Rep 2:488-93. 2002
  6. ncbi A short course of oral prednisone followed by intranasal budesonide is an effective treatment of severe nasal polyps
    Pedro Benitez
    Rhinology Unit, Department of Otorhinolaryngology ICEMEQ, Universitat de Barcelona, Barcelona, Spain
    Laryngoscope 116:770-5. 2006
  7. ncbi Dynamics of COX-2 in nasal mucosa and nasal polyps from aspirin-tolerant and aspirin-intolerant patients with asthma
    Laura Pujols
    Institut d Investigacions Biomediques August Pi i Sunyer, Barcelona, Spain
    J Allergy Clin Immunol 114:814-9. 2004
  8. doi Proteasome inhibition reduces proliferation, collagen expression, and inflammatory cytokine production in nasal mucosa and polyp fibroblasts
    Laura Pujols
    Clinical and Experimental Respiratory Immunoallergy, Institut d Investigacions Biomediques August Pi i Sunyer, and Centro de Investigaciones Respiratorias en Red de Enfermedades Respiratorias, Barcelona, Spain
    J Pharmacol Exp Ther 343:184-97. 2012
  9. doi Nuclear translocation of the glucocorticoid receptor in fibroblasts of asthmatic patients with nasal polyposis insensitive to glucocorticoid treatment
    Cristina Embid
    Servei de Pneumologia i Al lèrgia Respiratoria, Hospital Clinic, Barcelona, Espana
    Arch Bronconeumol 47:115-21. 2011
  10. ncbi Fluticasone furoate inhibits cytokine secretion from nasal epithelial cells and reduces eosinophil survival in an in vitro model of eosinophilic inflammation
    Joaquim Mullol
    Clinical and Experimental Respiratory Immunoallergy, CELLEX, Institut d Investigacions Biomediques August Pi i Sunyer IDIBAPS, Barcelona, Spain
    Int Arch Allergy Immunol 163:225-33. 2014

Collaborators

Detail Information

Publications82

  1. ncbi Cyclooxygenase-2 mRNA is downexpressed in nasal polyps from aspirin-sensitive asthmatics
    C Picado
    Servei de Pneumologia i Al lèrgia Respiratoria, Hospital Clinic, Departament de Medicina, Universitat de Barcelona, Spain
    Am J Respir Crit Care Med 160:291-6. 1999
    ..93 +/- 0. 52, sevenfold, p < 0.0001) and nasal mucosa (2.10 +/- 0.54, sixfold, p < 0.01). These findings suggest that an inadequate COX-2 regulation may be involved in AIAR...
  2. ncbi [Celecoxib in NSAID-induced cutaneous and respiratory adverse reactions]
    Antonio Valero
    Servicio de Neumología y Alergia Respiratoria Hospital Clínic Barcelona Spain
    Med Clin (Barc) 121:695-6. 2003
    ..Inhibition of COX-1 appears to be a key event in most non-steroidal anti-inflammatory drugs (NSAIDs)-induced adverse reactions. We evaluated celecoxib tolerance, a highly specific COX-2 inhibitor, in NSAIDs-sensitive patients...
  3. ncbi COX-2 specific inhibitors in NSAID-intolerant patients
    P Picado
    Servei de Pneumologia i Respiratória, Hospital Clinic, Department de Medicina, Universitat de Barcelona, Barcelona, Spain
    Int J Immunopathol Pharmacol 16:11-6. 2003
    ....
  4. ncbi NSAID-sensitive patients tolerate rofecoxib
    A Valero
    Servei de Pneumologia i Allergia Respiratoria, Hospital Clinic, Villarroel, 17008036, Barcelona, Spain
    Allergy 57:1214-5. 2002
  5. ncbi Aspirin intolerance and nasal polyposis
    Cesar Picado
    Servei de Pneumologia, Hospital Clinic, Barcelona, Spain
    Curr Allergy Asthma Rep 2:488-93. 2002
    ..The similarities in the reaction between the nose and airways in aspirin-sensitive patients provide compelling evidence for common pathogenic mechanisms for nasal polyps, chronic rhinosinusitis, and bronchial asthma...
  6. ncbi A short course of oral prednisone followed by intranasal budesonide is an effective treatment of severe nasal polyps
    Pedro Benitez
    Rhinology Unit, Department of Otorhinolaryngology ICEMEQ, Universitat de Barcelona, Barcelona, Spain
    Laryngoscope 116:770-5. 2006
    ..This study aimed to evaluate the effect of a short course of oral prednisone followed by intranasal budesonide on nasal symptoms, polyp size, nasal flow, and computed tomography scan...
  7. ncbi Dynamics of COX-2 in nasal mucosa and nasal polyps from aspirin-tolerant and aspirin-intolerant patients with asthma
    Laura Pujols
    Institut d Investigacions Biomediques August Pi i Sunyer, Barcelona, Spain
    J Allergy Clin Immunol 114:814-9. 2004
    ..Only dynamic studies can elucidate the discrepancies concerning the expression of the inducible COX-2 gene in inflammatory airway diseases...
  8. doi Proteasome inhibition reduces proliferation, collagen expression, and inflammatory cytokine production in nasal mucosa and polyp fibroblasts
    Laura Pujols
    Clinical and Experimental Respiratory Immunoallergy, Institut d Investigacions Biomediques August Pi i Sunyer, and Centro de Investigaciones Respiratorias en Red de Enfermedades Respiratorias, Barcelona, Spain
    J Pharmacol Exp Ther 343:184-97. 2012
    ..We conclude that noncytotoxic treatment with MG262 reduces the proliferative, fibrotic, and inflammatory response of nasal fibroblasts, whereas high MG262 concentrations induce apoptosis...
  9. doi Nuclear translocation of the glucocorticoid receptor in fibroblasts of asthmatic patients with nasal polyposis insensitive to glucocorticoid treatment
    Cristina Embid
    Servei de Pneumologia i Al lèrgia Respiratoria, Hospital Clinic, Barcelona, Espana
    Arch Bronconeumol 47:115-21. 2011
    ..Our aim was to establish whether the poor response to GC is due to an alteration in the translocation of the GR to the nucleus...
  10. ncbi Fluticasone furoate inhibits cytokine secretion from nasal epithelial cells and reduces eosinophil survival in an in vitro model of eosinophilic inflammation
    Joaquim Mullol
    Clinical and Experimental Respiratory Immunoallergy, CELLEX, Institut d Investigacions Biomediques August Pi i Sunyer IDIBAPS, Barcelona, Spain
    Int Arch Allergy Immunol 163:225-33. 2014
    ..The aim of this study was to investigate the effect of FF on eosinophil survival and cytokine secretion from nasal mucosa epithelial cells...
  11. ncbi Oral plus nasal corticosteroids improve smell, nasal congestion, and inflammation in sino-nasal polyposis
    Isam Alobid
    Rhinology Unit and Smell Clinic, Department of Otorhinolaryngology, Barcelona, Catalonia, Spain Institut d Investigacions Biomèdiques, August Pi i Sunyer IDIBAPS, Barcelona, Catalonia, Spain Centro de Investigación Biomédica en Red de Enfermedades Respiratorias, CibeRes, Barcelona, Catalonia, Spain
    Laryngoscope 124:50-6. 2014
    ..To assess the effect of oral plus intranasal corticosteroids on subjective outcomes (smell and nasal congestion) and objective outcomes (tissue eosinophilia and nitric oxide) in severe nasal polyposis (NP)...
  12. ncbi Glucocorticoid receptor isoforms alpha and beta in in vitro cytokine-induced glucocorticoid insensitivity
    Alfons Torrego
    Servei de Pneumologia, Hospital Clinic, Villarroel 170, 08036 Barcelona, Spain
    Am J Respir Crit Care Med 170:420-5. 2004
    ..GR-alpha, but not GR-beta, protein was detected at baseline and after cytokine exposure. Our data do not support the hypothesis that increased GR-beta expression can contribute to cytokine-induced glucocorticoid insensitivity...
  13. doi Locally administered prostaglandin E2 prevents aeroallergen-induced airway sensitization in mice through immunomodulatory mechanisms
    Rosa Torres
    Department of Pharmacology, Universitat Autonoma de Barcelona, Barcelona, Spain
    Pharmacol Res 70:50-9. 2013
    ..These findings suggest that the protection provided by PGE2 is a result of the modulation of early lung immunomodulatory mechanisms, and possibly a shift in the balance of dendritic cells towards a tolerogenic profile...
  14. doi Persistent asthma has an accumulative impact on the loss of smell in patients with nasal polyposis
    Isam Alobid
    Rhinology Unit and Smell Clinic, Department of Otorhinolaryngology, Hospital Clinic, University of Barcelona, Spain
    Rhinology 49:519-24. 2011
    ..Loss of sense of smell is one of the most frequent complaints in patients with nasal polyposis (NP). The aim of this study was to evaluate the impact of asthma and its severity on the sense of smell...
  15. doi Impact of cell culture methods on the outcomes of the in vitro inflammatory response in nasal polyps
    Laura Fernández-Bertolín
    Institut d Investigacions Biomediques August Pi i Sunyer IDIBAPS, Barcelona, Spain
    Rhinology 49:562-9. 2011
    ..In vitro culture of nasal polyp cells is frequently used in the investigation of inflammatory mechanisms and effect of treatments in nasal polyposis. Research outcomes may, however, be influenced by the culture methodology used...
  16. doi Differential expression of remodeling markers by tissue structure in nasal polyposis
    Francisco de Borja Callejas
    Hospital Clinic, Universitat de Barcelona, CIBER de Enfermedades Respiratorias, Spain
    Am J Rhinol Allergy 27:e69-74. 2013
    ..The aim of this study was to establish a qualitative/semiquantitative method of analysis on the expression of these remodeling markers in different tissue structures and eosinophils in both NPs and nasal mucosa (NM)...
  17. doi Low prostaglandin E2 and cyclooxygenase expression in nasal mucosa fibroblasts of aspirin-intolerant asthmatics
    Jordi Roca-Ferrer
    Immunoal lèrgia Respiratòria Clínica i Experimental, Institut d Investigacions Biomediques August Pi i Sunyer, Barcelona, Spain
    Respirology 18:711-7. 2013
    ..Whether these anomalies are specific to nasal polyps or affect all the nasal mucosa (NM) of upper airways is still unclear. The objective of this study was to compare the COX pathway in NM of AIA patients with the NM of control subjects...
  18. doi The importance of smell in patients with bronchiectasis
    Jose Maria Guilemany
    Rhinology Unit and Smell Clinic, Department of Otorhinolaryngology Head and Neck Surgery, Hospital Clinic i Universitari de Barcelona, Barcelona, Spain
    Respir Med 105:44-9. 2011
    ..The aim of the study was to evaluate the sense of smell in patients with bronchiectasis...
  19. doi The loss of smell in persistent allergic rhinitis is improved by levocetirizine due to reduction of nasal inflammation but not nasal congestion (the CIRANO study)
    Jose Maria Guilemany
    Rhinology Unit and Smell Clinic, Department of Otorhinolaryngology, Head and Neck Surgery, Hospital Clinic i Universitari de Barcelona, Barcelona, Spain
    Int Arch Allergy Immunol 158:184-90. 2012
    ..Persistent allergic rhinitis (PER) has a moderate impact on the sense of smell, but no controlled study has reported the effect of antihistamines on the loss of smell in patients with PER...
  20. doi Reduced expression of COXs and production of prostaglandin E(2) in patients with nasal polyps with or without aspirin-intolerant asthma
    Jordi Roca-Ferrer
    Immunoallergia Respiratoria Clinica i Experimental, Institut d Investigacions Biomediques August Pi i Sunyer IDIBAPS, Barcelona, Spain
    J Allergy Clin Immunol 128:66-72.e1. 2011
    ..Researchers have debated whether regulation of the COX enzymes (COX-1 and COX-2), which mediate production of prostaglandins (PGs), affects the pathogenesis of nasal polyps (NPs) and aspirin-intolerant asthma (AIA)...
  21. pmc An intranasal selective antisense oligonucleotide impairs lung cyclooxygenase-2 production and improves inflammation, but worsens airway function, in house dust mite sensitive mice
    Rosa Torres
    Department of Pneumology and Respiratory Allergy, Hospital Clinic, IDIBAPS, Universitat de Barcelona, Barcelona, Spain
    Respir Res 9:72. 2008
    ....
  22. pmc Signal transduction pathways (MAPKs, NF-κB, and C/EBP) regulating COX-2 expression in nasal fibroblasts from asthma patients with aspirin intolerance
    Francesc Josep Garcia-Garcia
    Immunoal lèrgia Respiratòria Clínica i Experimental IRCE, Institut d Investigacions Biomediques August Pi i Sunyer IDIBAPS, Barcelona, Catalonia, Spain
    PLoS ONE 7:e51281. 2012
    ..Recent studies have revealed that cyclooxygenase-2 (COX-2) expression is down-regulated in aspirin-induced asthma (AIA). Various signal pathways (MAPKs, NF-κB and C/EBP) are involved in COX-2 regulation...
  23. pmc Mometasone and desloratadine additive effect on eosinophil survival and cytokine secretion from epithelial cells
    Joaquim Mullol
    IDIBAPS, Hospital Clinic, Ciber de enfermedades respiratorias CIBERES, Villarroel 170, Barcelona, 08036, Catalonia, Spain
    Respir Res 12:23. 2011
    ....
  24. ncbi Cyclooxygenase-2 is up-regulated in lung parenchyma of chronic obstructive pulmonary disease and down-regulated in idiopathic pulmonary fibrosis
    Antoni Xaubet
    Servei de Pneumologia i Allergia Respiratoria, Institut Clinic de Pneumologia i Cirurgia Toracica, Barcelona, Spain
    Sarcoidosis Vasc Diffuse Lung Dis 21:35-42. 2004
    ..In vitro studies have suggested that fibroblasts from idiopathic pulmonary fibrosis (IPF) may have an impaired induction of cyclooxygenase (Cox)-2. We have investigated Cox-1 and Cox-2 expression in lung tissue from IPF...
  25. ncbi The impact of atopy, sinus opacification, and nasal patency on quality of life in patients with severe nasal polyposis
    Isam Alobid
    Rhinology Unit, Department of Otorhinolaryngology ICEMEQ, Institut d Investigacions Biomediques August Pi i Sunyer IDIBAPS, Hospital Clinic, Barcelona, Spain
    Otolaryngol Head Neck Surg 134:609-12. 2006
    ..Nasal polyposis has a great impact on the quality of life. The aim of this study was to evaluate the association between quality of life and atopy, sinus opacification, and nasal patency in severe nasal polyposis...
  26. doi Rhinosinusitis and nasal polyps in aspirin-exacerbated respiratory disease
    Joaquim Mullol
    Rhinology Unit and Smell Clinic, Department of Otorhinolaryngology, Hospital Clinic i Universitari, University of Barcelona, Barcelona, Catalonia, Spain
    Immunol Allergy Clin North Am 33:163-76. 2013
    ..This article explores the clinical aspects, physiopathology, and treatment of rhinosinusitis as it relates to AERD...
  27. doi Platelet-activating factor nasal challenge induces nasal congestion and reduces nasal volume in both healthy volunteers and allergic rhinitis patients
    Rosa Muñoz-Cano
    Unitat Allèrgia, Pneumologia i Allèrgia Respiratòria Hospital Clínic, Universitat de Barcelona, Barcelona, Spain
    Am J Rhinol Allergy 27:e48-52. 2013
    ..Clinical and experimental findings suggest that PAF participates in allergic rhinitis (AR) pathogenesis. The aim was to assess the PAF ability to induce clinical response in nasal airway after local stimulation...
  28. doi Subcutaneous prostaglandin E(2) restrains airway mast cell activity in vivo and reduces lung eosinophilia and Th(2) cytokine overproduction in house dust mite-sensitive mice
    Aida Herrerias
    Department of Pharmacology, Universitat Autonoma de Barcelona, ES 08193 Bellaterra, Barcelona, Spain
    Int Arch Allergy Immunol 149:323-32. 2009
    ..However, in vivo evidence is scarce...
  29. doi Lower sensitivity of nasal polyp fibroblasts to glucocorticoid anti-proliferative effects
    Laura Pujols
    Clinical and Experimental Respiratory Immunoallergy, Institut d Investigacions Biomediques August Pi i Sunyer IDIBAPS, Hospital Clinic, Villarroel 170, 08036 Barcelona, Catalonia, Spain
    Respir Med 105:218-25. 2011
    ..Fibroblasts are involved in both inflammation and remodelling of NP. We aimed to evaluate whether NP fibroblasts are less sensitive to GCs' anti-proliferative and anti-inflammatory effects, compared to nasal mucosa (NM) fibroblasts...
  30. ncbi Aspirin-intolerant asthma: role of cyclo-oxygenase enzymes
    Cesar Picado
    Servicio de Neumologia y Alergia Respiratoria, Instituto de Neumología y Cirugía Torácica, Hospital Clinic, Villaroel 170, E 08036 Barcelona, Spain
    Allergy 57:58-60. 2002
    ....
  31. doi Persistent allergic rhinitis has a moderate impact on the sense of smell, depending on both nasal congestion and inflammation
    Jose Maria Guilemany
    Rhinology Unit and Smell Clinic, Department of Otorhinolaryngology, Barcelona, Catalonia, Spain
    Laryngoscope 119:233-8. 2009
    ..The aims of the study were to evaluate the impact of PER on the sense of smell, and to characterize this impact based on self-reported hyposmia (SRH) and PER severity...
  32. pmc Reconstituted human upper airway epithelium as 3-d in vitro model for nasal polyposis
    Francisco de Borja Callejas
    Clinical and Experimental Respiratory Immunoallergy, Institut d Investigacions Biomediques August Pi i Sunyer IDIBAPS, Barcelona, Spain CIBER of Respiratory Diseases CIBERES, Barcelona, Spain
    PLoS ONE 9:e100537. 2014
    ..However, neither characterization of mucociliar differentiation overtime nor the inflammatory function of reconstituted nasal polyp (NP) epithelia have been described...
  33. ncbi Barcelona Smell Test - 24 (BAST-24): validation and smell characteristics in the healthy Spanish population
    Alda Cardesin
    Unitat de Rinologia, Servei d Otorinolaringologia ICEMEQ, Barcelona, Spain
    Rhinology 44:83-9. 2006
    ..Smell tests for clinical use have been developed in different countries, but no single test has gained general acceptance. The objectives of the study were to evaluate the smell outcomes in a Spanish population...
  34. ncbi Importance of glucocorticoid receptors in upper and lower airways
    Laura Pujols
    Immunoallergia Respiratoria Clinica i Experimental, Institut d Investigacions Biomediques August Pi i Sunyer, Hospital Clinic, Catalonia, Spain
    Front Biosci (Landmark Ed) 15:789-800. 2010
    ..In addition to GR beta, other mechanisms explaining GC resistance include alterations in GR binding to ligand, nuclear translocation, and binding to GRE, and/or a defective cross-talk with transcription factors and cofactors...
  35. pmc Activity of the cyclooxygenase 2-prostaglandin-E prostanoid receptor pathway in mice exposed to house dust mite aeroallergens, and impact of exogenous prostaglandin E2
    Aida Herrerias
    Department of Pharmacology, Universitat Autonoma de Barcelona, Barcelona, Spain
    J Inflamm (Lond) 6:30. 2009
    ..We analyzed the activity of the pathway in mice sensitized to aeroallergens, and then studied its modulation under exogenous PGE2...
  36. doi Safety of parecoxib in asthmatic patients with aspirin-exacerbated respiratory disease
    Antonio Valero
    Department of Pneumology and Respiratory Allergy, Allergy Unit, Hospital Clinic, Barcelona, Spain
    Int Arch Allergy Immunol 156:221-3. 2011
    ..The aim of the study is to assess the tolerance of parecoxib (Dynastat; Pfizer) given by intramuscular route in patients with AERD...
  37. ncbi Expression of glucocorticoid receptor alpha- and beta-isoforms in human cells and tissues
    Laura Pujols
    Institut d Investigacions Biomediques August Pi i Sunyer, Hospital Clinic, Departament de Medicina, Universitat de Barcelona, 08036 Barcelona, Spain
    Am J Physiol Cell Physiol 283:C1324-31. 2002
    ..Our results suggest that, in physiological conditions, the default splicing pathway is the one leading to GR-alpha. The alternative splicing event leading to GR-beta is minimally activated...
  38. ncbi Role of Art v 3 in pollinosis of patients allergic to Pru p 3
    Jaime Sánchez-López
    Unitat d Al lèrgia, Institut Clínic del Torax ICT, Hospital Clinic, Institut d Investigacions Biomediques August Pi i Sunyer IDIBAPS, Universitat de Barcelona, Barcelona, Spain Electronic address
    J Allergy Clin Immunol 133:1018-25. 2014
    ..Although in vitro cross-reactivity is already well known, it has yet to be elucidated whether a pollen LTP can induce rhinitis...
  39. doi Omalizumab therapy in severe asthma: experience from the Spanish registry--some new approaches
    Maria del Carmen Vennera
    Department of Pneumology and Respiratory Allergy, Hospital Clinic, Universitat de Barcelona, Barcelona, Spain
    J Asthma 49:416-22. 2012
    ..The main objective of this study was to evaluate the efficacy and tolerability of omalizumab in a real-life setting in Spain, particularly in those patients with immunoglobulin E (IgE) levels out of range...
  40. ncbi Alpha and beta glucocorticoid receptors: relevance in airway diseases
    Laura Pujols
    Servei d Otorinolaringologia, Hospital Clinic, Villarroel 170, 08036, Barcelona, Spain
    Curr Allergy Asthma Rep 7:93-9. 2007
    ..However, the role of GRbeta in modulating GC sensitivity in vivo has been highly debated and is as yet unclear...
  41. pmc Lung myofibroblasts are characterized by down-regulated cyclooxygenase-2 and its main metabolite, prostaglandin E2
    Marta Gabasa
    Institut d Investigacions Biomediques August Pi i Sunyer, Barcelona, Spain
    PLoS ONE 8:e65445. 2013
    ..Our aim was to investigate the expression of COX-2 and PGE2 in human lung myofibroblasts and establish whether fibroblast-myofibroblast transition (FMT) and EMT are associated with COX-2 and PGE2 down-regulation...
  42. ncbi Severe nasal polyposis and its impact on quality of life. The effect of a short course of oral steroids followed by long-term intranasal steroid treatment
    Isam Alobid
    Rhinology Unit, Department of Otorhinolaryngology ICEMEQ, Hospital Clinic, Universitat de Barcelona, Spain
    Rhinology 44:8-13. 2006
    ..The aims of this study were to evaluate the quality of life in nasal polyp patients after: (1) a short course of oral steroids; and (2) a long-term treatment with intranasal steroids...
  43. doi [Inflammatory response of rapid onset asthma exacerbation]
    Jesus Bellido-Casado
    Departament de Pneumologia, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain
    Arch Bronconeumol 46:587-93. 2010
    ..The association between onset of asthma exacerbation and the inflammatory response has not been sufficiently studied...
  44. ncbi Glucocorticoid receptor in human respiratory epithelial cells
    Laura Pujolsa
    Immunoal lèrgia Respiratòria Clínica i Experimental, Institut d Investigacions Biomediques August Pi i Sunyer IDIBAPS, Hospital Clinic, Barcelona, Spain
    Neuroimmunomodulation 16:290-9. 2009
    ..However, the role of GRbeta in modulating GC sensitivity in vivo has been highly debated and is as yet unclear...
  45. doi Validation of the Spanish version of the Asthma Control Questionnaire
    Cesar Picado
    Department of Pneumology, Hospital Clinic, Barcelona, Spain
    Clin Ther 30:1918-31. 2008
    ..The Asthma Control Questionnaire (ACQ) has not been validated in the Spanish population, and the fact that it requires spirometry poses an important limitation on its widespread use in the primary care setting in Spain...
  46. ncbi Mechanisms of aspirin sensitivity
    Cesar Picado
    Pneumology and Respiratory Allergy Service, University of Barcelona Hospital Clinic, Villarroel 170, 08036 Barcelona, Barcelona, Spain
    Curr Allergy Asthma Rep 6:198-202. 2006
    ..There has been no explanation to date that connects all these findings, although an anomaly in the regulation of Cox-2 is probably accountable...
  47. doi Psychological profile of patients with bronchial asthma and functional dyspnea: a comparison with a non-asthmatic population and impact on the disease
    Carlos Martinez-Rivera
    Servicio de Neumologia, Hospital Universitari Germans Trias i Pujol, Universitat Autonoma de Barcelona, Badalona, Barcelona, Spain
    Arch Bronconeumol 47:73-8. 2011
    ..The aim of this study was to assess the prevalence of DD in asthma, its impact on quality of life and asthma control and its relationship with anxiety and alexithymia...
  48. ncbi Cyclooxygenase 1 and cyclooxygenase 2 expression is abnormally regulated in human nasal polyps
    Joaquim Mullol
    Institut d Investigacions Biomediques August Pi i Sunyer, Institut Clinic de Pneumologia i Cirurgia Toracica, Hospital Clinic, Barcelona, Spain
    J Allergy Clin Immunol 109:824-30. 2002
    ..There is evidence that impairment of prostanoid metabolism might be involved in the pathogenesis of nasal polyps (NPs). Prostanoids are synthesized by 2 cyclooxygenase (Cox) enzymes, one constitutive (Cox-1) and another inducible (Cox-2)...
  49. doi Quantification of major urinary metabolites of PGE2 and PGD2 in cystic fibrosis: correlation with disease severity
    Suha Jabr
    Servei de Pneumologia, Hospital Cínic, Institut d Investigacions Biomediques August Pi i Sunyer IDIBAPS, CibeRes, Universitat de Barcelona, 08036 Barcelona, Spain
    Prostaglandins Leukot Essent Fatty Acids 89:121-6. 2013
    ..67; 13.67-28.62ng/mg Cr, n=5) and severe (22.82; 10.67-84.13ng/mg Cr). Our study confirms the key role of CFTR in the regulation of the cyclooxygenase pathway of arachidonic acid metabolism found in in vitro studies. ..
  50. ncbi [Triamcinolone acetonide in the treatment of corticosteroid-resistant asthma: risks and benefits]
    Cesar Picado
    Servei de Pneumologia, Hospital Clinic, Universitat de Barcelona, Barcelona, Spain
    Arch Bronconeumol 44:324-7. 2008
    ..Therefore, TA can be considered a useful option for the treatment of patients with severe prednisone-resistant asthma...
  51. ncbi [Incidence and characteristics of asthma exacerbations in Barcelona (ASMAB II)]
    Ferran Morell
    Servei de Pneumologia, Hospital Universitari Vall d Hebron, Departament de Medicina, Universitat Autonoma de Barcelona, Barcelona, Espana
    Arch Bronconeumol 45:550-5. 2009
    ..A study has been made on the incidence and clinical characteristics of asthma exacerbations (AE) seen in hospital emergency departments (HED) and domiciliary services (DS) in Barcelona...
  52. ncbi Control of ventilation, breathlessness perception and alexithymia in near-fatal asthma
    Vicente Plaza
    Department of Pneumology, Hospital de la Santa Creu i de Sant Pau, Barcelona, Spain
    J Asthma 43:639-44. 2006
    ..Neither altered breathlessness perception nor ventilatory response to hypoxia seems to play a role in NFA, although alexithymia may favor poor clinical control...
  53. ncbi Rupatadine: pharmacological profile and its use in the treatment of allergic disorders
    Cesar Picado
    University of Barcelona, Servei de Pneumologia i Allergia Respiratoria, Hospital Clinic, C Villarroel 170, 08036 Barcelona, Spain
    Expert Opin Pharmacother 7:1989-2001. 2006
    ..Rupatadine does not present drug-drug interactions with azithromycin, fluoxetine and lorazepam, but should not be administered concomitantly with known CYP3A4 inhibitors...
  54. ncbi Usefulness of montelukast to prevent adverse reactions to COX-2 selective inhibitors: a case report
    C Serrano
    Allergy Unit Hospital Clinic Barcelona Spain
    J Investig Allergol Clin Immunol 15:156-7. 2005
    ....
  55. ncbi Glucocorticoid receptors in human airways
    L Pujols
    Institut d Investigacions Biomediques August Pi i Sunyer, Barcelona, Spain
    Allergy 59:1042-52. 2004
    ..However, the possible role of GRbeta in modulating glucocorticoid sensitivity and/or resistance in vivo has been highly debated and it is not yet clear...
  56. ncbi Nuclear factor-kappaB activity is down-regulated in nasal polyps from aspirin-sensitive asthmatics
    C Picado
    Servei de Pneumologia i Allergia Respiratoria, Institut Clinic de Pneumologia i Cirurgia Toracica, Universitat de Barcelona, Barcelona, Spain
    Allergy 58:122-6. 2003
    ..We examined whether a decreased activity of nuclear factor(NF)-kappaB), a transcriptional regulator of cyclooxygenase-2 (COX-2), could account for down-regulation of COX-2 in nasal polyps of aspirin-sensitive asthmatics...
  57. ncbi Non-steroidal anti-inflammatory drugs-induced urticaria and angioedema: more research on mechanisms needed
    C Picado
    Clin Exp Allergy 35:698-9. 2005
  58. ncbi Safety of triflusal (antiplatelet drug) in patients with aspirin-exacerbated respiratory diseases
    J Fraj
    Department of Allergology, Hospital Clinico Lozano Blesa, Zaragoza, Spain
    Allergy 63:112-5. 2008
    ..The aim of the study was to assess the tolerability of triflusal in patients with aspirin-exacerbated respiratory disease (AERD)...
  59. ncbi EAACI/GA2LEN guideline: aspirin provocation tests for diagnosis of aspirin hypersensitivity
    E Nizankowska-Mogilnicka
    Department of Medicine, Jagiellonian University School of Medicine, Krakow, Poland
    Allergy 62:1111-8. 2007
    ..Indications, contraindications for the tests, the rules of drug withdrawal and equipment are reviewed. Patient supervision and interpretations of the tests are proposed...
  60. ncbi Effect of desloratadine on epithelial cell granulocyte-macrophage colony-stimulating factor secretion and eosinophil survival
    J Mullol
    IDIBAPS, Rhinology Unit, ENT Department, Hospital Clinic, Deparmtent of Medicine, Universitat de Barcelona, Barcelona, Catalonia, Spain
    Clin Exp Allergy 36:52-8. 2006
    ..Second-generation antihistamines are H(1) receptor antagonists and may have additional anti-inflammatory effects...
  61. pmc Upregulation of COX-1 and COX-2 in nasal polyps in cystic fibrosis
    J Roca-Ferrer
    Institut d Investigaccions Biomèdiques, August Pi Syuner, IDIBAPS, Barcelona, Spain
    Thorax 61:592-6. 2006
    ..Since abnormalities in prostanoid metabolism occur in the lower airway of patients with cystic fibrosis (CF), it is likely that they could also be detected in the nose...
  62. ncbi Frequency and clinical characteristics of rapid-onset fatal and near-fatal asthma
    V Plaza
    Dept de Pneumologia, Hospital Santa Creu i Sant Pau, Universitat Autonoma de Barcelona, Barcelona, Spain corrected
    Eur Respir J 19:846-52. 2002
    ..These findings also support a distinct clinical profile for rapid-onset asthma marked by differences in triggers, severity of exacerbation and clinical course...
  63. ncbi [Relation between rhinosinusitis and bronchiectasis]
    J M Guilemany
    Unitat de Rinologia, Servei d ORL ICEMEQ, Hospital Clinic, Universitat de Barcelona, Barcelona, Spain
    Arch Bronconeumol 42:135-40. 2006
    ..This review considers the diseases in which bronchiectasis occurs along with sinonasal manifestations. We propose examining sinonasal disease from a new perspective by observing it in patients with bronchiectasis...
  64. ncbi Proinflammatory cytokines and eosinophil cationic protein on glandular secretion from human nasal mucosa: regulation by corticosteroids
    J Roca-Ferrer
    , IDIBAPS, Barcelona, Spain
    J Allergy Clin Immunol 108:87-93. 2001
    ..Corticosteroids may reduce nasal hypersecretion by blocking the direct effect of proinflammatory cytokines on glandular output...
  65. ncbi Effect of budesonide and nedocromil sodium on IL-6 and IL-8 release from human nasal mucosa and polyp epithelial cells
    A Xaubet
    , , , Barcelona, Spain
    Respir Med 95:408-14. 2001
    ..The different effect of budesonide and nedocromil sodium on IL-6 and IL-8 release may be explained by differences in the mechanisms which regulate the upregulation of these cytokines in inflammatory responses...
  66. ncbi Mucin genes have different expression patterns in healthy and diseased upper airway mucosa
    A Martínez-Antón
    Institut d Investigacions Biomediques August Pi i Sunyer IDIBAPS, Barcelona, Catalonia, Spain
    Clin Exp Allergy 36:448-57. 2006
    ..Since mucins are major components of mucus, the knowledge of their distribution and regulation in nasal tissues is likely to improve mucus hyper-secretion therapy...
  67. ncbi The impact of bronchiectasis associated to sinonasal disease on quality of life
    J M Guilemany
    Rhinology Unit, Department of Otorhinolaryngology, Hospital Clinic de Barcelona, ENT, Barcelona, Spain
    Respir Med 100:1997-2003. 2006
    ..Associations between upper and lower airways diseases have been demonstrated in allergic rhinitis and asthma, nasal polyposis and asthma, chronic obstructive lung disease and chronic rhinosinusitis...
  68. ncbi Dietary micronutrients/antioxidants and their relationship with bronchial asthma severity
    C Picado
    , Departament de Medicina, Universitat de Barcelona, Spain
    Allergy 56:43-9. 2001
    ..Reduction of platelet GSH-Px activity in the most severe patients suggests that these patients have a diminished capacity to restore part of the antioxidant defences...
  69. ncbi Alexithymia: a relevant psychological variable in near-fatal asthma
    J Serrano
    Departament de Pneumologia, Hospital de la Santa Creu i Sant Pau, Universitat Autonoma de Barcelona, Barcelona, corrected Spain
    Eur Respir J 28:296-302. 2006
    ..The results show that alexithymia is more frequent in near-fatal asthma patients compared to the rest of asthmatics and is associated with recurrent very severe asthma exacerbations...
  70. ncbi Expression of the human glucocorticoid receptor alpha and beta isoforms in human respiratory epithelial cells and their regulation by dexamethasone
    L Pujols
    Institut d Investigacions Biomediques August Pi i Sunyer, Institut Clínic de Pneumologia i Cirurgia Toràcica and Servei d Otorinolaringologia, Hospital Germans Trias i Pujol de Badalona, Barcelona, Catalonia, Spain
    Am J Respir Cell Mol Biol 24:49-57. 2001
    ....
  71. ncbi [Rhinitis and asthma: one airway, one disease]
    C Serrano
    Servicio de Neumologia y Alergia Respiratoria, ICPCT, Hospital Clinic, Barcelona, Spain
    Arch Bronconeumol 41:569-78. 2005
  72. ncbi Validation of the Spanish version of the Asthma Control Test (ACT)
    J M Vega
    Department of Allergy, Hospital Carlos Haya, Malaga, Spain
    J Asthma 44:867-72. 2007
    ..Validation of the Spanish version of the Asthma Control Test (ACT)...
  73. doi Regulation of glucocorticoid receptor in nasal polyps by systemic and intranasal glucocorticoids
    L Pujols
    Clinical and Experimental Respiratory Immunoallergy, Institut d Investigacions Biomediques August Pi i Sunyer, Barcelona, Spain
    Allergy 63:1377-86. 2008
    ..We aimed to evaluate the in vivo regulation of GR isoforms in GC-treated nasal polyps and to assess the relationship between clinical response to GCs and GR levels...
  74. ncbi [Use of the mouse to unravel allergic asthma: a review of the pathogenesis of allergic asthma in mouse models and its similarity to the condition in humans]
    R Torres
    Departamento de Farmacologia, de Terapéutica y de Toxicología, Universidad Autonoma de Barcelona, Cerdanyola del Valles, Barcelona, Spain
    Arch Bronconeumol 41:141-52. 2005
  75. ncbi Nasal polyposis and its impact on quality of life: comparison between the effects of medical and surgical treatments
    I Alobid
    Department of Otorhinolaryngology, Rhinology Unit, Hospital Clinic, University of Barcelona, Barcelona, Spain
    Allergy 60:452-8. 2005
    ....
  76. ncbi Nasal and bronchial response to exercise in patients with asthma and rhinitis: the role of nitric oxide
    A Valero
    Unidad de Alergia, Servicio de Neumología y Alerdia Respiratoria, Hospital Clinic, Universitat de Barcelona, Barcelona, Spain
    Allergy 60:1126-31. 2005
    ..The objective was to evaluate the relationship between the levels of nasal nitric oxide (nNO) and exhaled bronchial nitric oxide (eNO) with bronchial responses to exercise in patients with rhinitis and asthma...
  77. doi Corticosteroid therapy increases membrane-tethered while decreases secreted mucin expression in nasal polyps
    A Martínez-Antón
    Immunoal lèrgia Respiratòria Clínica i Experimental, Institut d Investigacions Biomediques August Pi i Sunyer, Barcelona, Spain
    Allergy 63:1368-76. 2008
    ..However, their effect on mucin production is not well-understood. The aim of this (pilot) study was to investigate CS effect on mucin expression in NP...
  78. pmc Expression of glucocorticoid receptors alpha and beta in steroid sensitive and steroid insensitive interstitial lung diseases
    L Pujols
    Institut d Investigacions Biomediques August Pi i Sunyer, Barcelona, Spain
    Thorax 59:687-93. 2004
    ....
  79. ncbi Occupational asthma and rhinoconjunctivitis caused by cricket allergy
    J Bartra
    Allergy Unit, Pneumology Department, Hospital Clinic, Barcelona, Spain
    J Investig Allergol Clin Immunol 18:141-2. 2008
  80. pmc Effect of montelukast added to inhaled budesonide on control of mild to moderate asthma
    M J Vaquerizo
    Merck Sharp and Dohme, c Josefa Valcarcel 38, 28027 Madrid, Spain
    Thorax 58:204-10. 2003
    ..A 16 week multicentre, randomised, double blind, controlled study was undertaken to study the efficacy of adding oral montelukast, a leukotriene receptor antagonist, to a constant dose of inhaled budesonide...
  81. doi Rupatadine in allergic rhinitis and chronic urticaria
    J Mullol
    Unitat de Rinologia, Servei d ORL, Hospital Clinic, IDIBAPS, Barcelona, Spain
    Allergy 63:5-28. 2008
    ....
  82. ncbi [Response to glucocorticoid treatment in asthma. The role of alpha and beta isoforms of the glucocorticoid receptor]
    A Torrego
    Servei de Pneumologia, Institut Clinic de Pneumologia i Cirurgia Toracica, Universitat de Barcelona, IDIBAPS, Hospital Clinic, Universitat de Barcelona, Spain
    Arch Bronconeumol 38:436-40. 2002