Ivan Penuelas

Summary

Affiliation: University of Navarra
Country: Spain

Publications

  1. ncbi request reprint Positron emission tomography imaging of adenoviral-mediated transgene expression in liver cancer patients
    Ivan Penuelas
    Department of Nuclear Medicine, Clinica Universitaria de Navarro, Pamplona, Spain
    Gastroenterology 128:1787-95. 2005
  2. pmc PET Tracers for Clinical Imaging of Breast Cancer
    Ivan Penuelas
    Department of Nuclear Medicine, University Clinic of Navarra, Avenida Pio XII 36, 31008 Pamplona, Spain
    J Oncol 2012:710561. 2012
  3. ncbi request reprint cAMP activates transcription of the human glucocorticoid receptor gene promoter
    I Penuelas
    Department of Biochemistry and Molecular Biology, University of Navarra School of Medicine, Pamplona, Spain
    J Steroid Biochem Mol Biol 67:89-94. 1998
  4. ncbi request reprint 18F-FDG metabolism in a rat model of chronic infarction: a 17-sector semiquantitative analysis
    I Penuelas
    Department of Nuclear Medicine, Clinica Universitaria de Navarra, Av Pio XII 36, 31008 Pamplona, Spain
    Nuklearmedizin 46:149-54. 2007
  5. ncbi request reprint (13)N-ammonia PET as a measurement of hindlimb perfusion in a mouse model of peripheral artery occlusive disease
    Ivan Penuelas
    Department of Nuclear Medicine, Clinica Universitaria, University of Navarra, Pamplona, Spain
    J Nucl Med 48:1216-23. 2007
  6. ncbi request reprint Gene therapy imaging in patients for oncological applications
    Ivan Penuelas
    Department of Nuclear Medicine, University Hospital, University of Navarra, Pamplona, Spain
    Eur J Nucl Med Mol Imaging 32:S384-403. 2005
  7. ncbi request reprint Positron emission tomography and gene therapy: basic concepts and experimental approaches for in vivo gene expression imaging
    Ivan Penuelas
    Department of Nuclear Medicine, Clinica Universitaria de Navarra, Pamplona, Spain
    Mol Imaging Biol 6:225-38. 2004
  8. doi request reprint The HIF-1α hypoxia response in tumor-infiltrating T lymphocytes induces functional CD137 (4-1BB) for immunotherapy
    Asis Palazon
    CIMA and CUN University of Navarra, Pamplona, Navarra, Spain
    Cancer Discov 2:608-23. 2012
  9. doi request reprint Adipose stromal vascular fraction improves cardiac function in chronic myocardial infarction through differentiation and paracrine activity
    Manuel Mazo
    Hematology and Cell Therapy and Foundation for Applied Medical Research, Division of Cancer, Clinica Universitaria, University of Navarra, Navarra, Spain
    Cell Transplant 21:1023-37. 2012
  10. ncbi request reprint Simple automated system for simultaneous production of 11C-labeled tracers by solid supported methylation
    Gemma Quincoces
    Department of Nuclear Medicine, University Hospital, University of Navarra School of Medicine, Av Pio XII 36, 31008 Pamplona, Spain
    Appl Radiat Isot 64:808-11. 2006

Collaborators

Detail Information

Publications44

  1. ncbi request reprint Positron emission tomography imaging of adenoviral-mediated transgene expression in liver cancer patients
    Ivan Penuelas
    Department of Nuclear Medicine, Clinica Universitaria de Navarro, Pamplona, Spain
    Gastroenterology 128:1787-95. 2005
    ....
  2. pmc PET Tracers for Clinical Imaging of Breast Cancer
    Ivan Penuelas
    Department of Nuclear Medicine, University Clinic of Navarra, Avenida Pio XII 36, 31008 Pamplona, Spain
    J Oncol 2012:710561. 2012
    ..Furthermore, molecules related with the tumour microenvironment, tumour induced angiogenesis or even hypoxia could also be used as molecular biomarkers for breast cancer imaging...
  3. ncbi request reprint cAMP activates transcription of the human glucocorticoid receptor gene promoter
    I Penuelas
    Department of Biochemistry and Molecular Biology, University of Navarra School of Medicine, Pamplona, Spain
    J Steroid Biochem Mol Biol 67:89-94. 1998
    ....
  4. ncbi request reprint 18F-FDG metabolism in a rat model of chronic infarction: a 17-sector semiquantitative analysis
    I Penuelas
    Department of Nuclear Medicine, Clinica Universitaria de Navarra, Av Pio XII 36, 31008 Pamplona, Spain
    Nuklearmedizin 46:149-54. 2007
    ..Strategies to establish the functional benefit of cell therapy in cardiac regeneration and the potential mechanism are needed...
  5. ncbi request reprint (13)N-ammonia PET as a measurement of hindlimb perfusion in a mouse model of peripheral artery occlusive disease
    Ivan Penuelas
    Department of Nuclear Medicine, Clinica Universitaria, University of Navarra, Pamplona, Spain
    J Nucl Med 48:1216-23. 2007
    ..The development of noninvasive methods for assessment and comparison of the efficacy of novel therapies in animal models is of great importance...
  6. ncbi request reprint Gene therapy imaging in patients for oncological applications
    Ivan Penuelas
    Department of Nuclear Medicine, University Hospital, University of Navarra, Pamplona, Spain
    Eur J Nucl Med Mol Imaging 32:S384-403. 2005
    ..Finally, the advantages of designing a gene therapy-based clinical trial with imaging fully integrated from the very beginning are discussed and future perspectives for the development of these applications outlined...
  7. ncbi request reprint Positron emission tomography and gene therapy: basic concepts and experimental approaches for in vivo gene expression imaging
    Ivan Penuelas
    Department of Nuclear Medicine, Clinica Universitaria de Navarra, Pamplona, Spain
    Mol Imaging Biol 6:225-38. 2004
    ....
  8. doi request reprint The HIF-1α hypoxia response in tumor-infiltrating T lymphocytes induces functional CD137 (4-1BB) for immunotherapy
    Asis Palazon
    CIMA and CUN University of Navarra, Pamplona, Navarra, Spain
    Cancer Discov 2:608-23. 2012
    ..As a result, low-dose intratumoral injections avoid liver inflammation, achieve antitumor systemic effects, and permit synergistic therapeutic effects with PD-L1/B7-H1 blockade...
  9. doi request reprint Adipose stromal vascular fraction improves cardiac function in chronic myocardial infarction through differentiation and paracrine activity
    Manuel Mazo
    Hematology and Cell Therapy and Foundation for Applied Medical Research, Division of Cancer, Clinica Universitaria, University of Navarra, Navarra, Spain
    Cell Transplant 21:1023-37. 2012
    ..These results show the potential of SVF to contribute to the regeneration of ischemic tissue and to provide a long-term functional benefit in a rat model of chronic MI, by both direct and indirect mechanisms...
  10. ncbi request reprint Simple automated system for simultaneous production of 11C-labeled tracers by solid supported methylation
    Gemma Quincoces
    Department of Nuclear Medicine, University Hospital, University of Navarra School of Medicine, Av Pio XII 36, 31008 Pamplona, Spain
    Appl Radiat Isot 64:808-11. 2006
    ..Furthermore, it can be used for multiple simultaneous synthesis...
  11. doi request reprint Molecular imaging techniques to study the biodistribution of orally administered (99m)Tc-labelled naive and ligand-tagged nanoparticles
    Paloma Areses
    Department of Nuclear Medicine, Clinica Universidad de Navarra, University Clinic of Navarra, Pamplona, Spain
    Mol Imaging Biol 13:1215-23. 2011
    ..Study by molecular imaging the biodistribution of poly(anhydride) nanoparticles after oral administration...
  12. doi request reprint MAPC transplantation confers a more durable benefit than AC133+ cell transplantation in severe hind limb ischemia
    Xabier L Aranguren
    Hematology Service and Cell Therapy, Foundation for Applied Medical Research, Division of Cancer, University of Navarra, Pamplona, Spain
    Cell Transplant 20:259-69. 2011
    ..This, in turn, conferred tissue protection and regeneration with longer term functional improvement...
  13. doi request reprint Transplantation of mesenchymal stem cells exerts a greater long-term effect than bone marrow mononuclear cells in a chronic myocardial infarction model in rat
    Manuel Mazo
    Hematology and Cell Therapy and Division of Cancer, Clinica Universitaria and Foundation for Applied Medical Research, University of Navarra, Navarra, Spain
    Cell Transplant 19:313-28. 2010
    ..Altogether, results show that MSC provides a long-term superior benefit than whole BM-MNC transplantation in a rat model of chronic MI...
  14. doi request reprint Voxel-based analysis of dual-time-point 18F-FDG PET images for brain tumor identification and delineation
    Elena Prieto
    Department of Nuclear Medicine, Clinica Universidad de Navarra, Pamplona, Spain
    J Nucl Med 52:865-72. 2011
    ..We have investigated dual-time-point (18)F-FDG PET for the detection and delineation of high-grade brain tumors using quantitative criteria applied on a voxel basis...
  15. doi request reprint Conjunctival vaccination against Brucella ovis in mice with mannosylated nanoparticles
    Raquel Da Costa Martins
    Dpt Pharmacy and Pharmaceutical Technology, University of Navarra, Pamplona, Spain
    J Control Release 162:553-60. 2012
    ..In summary, mannosylated nanoparticles appear to be a safe and suitable adjuvant for conjunctival vaccination...
  16. doi request reprint Adeno-associated virus liver transduction efficiency measured by in vivo [18F]FHBG positron emission tomography imaging in rodents and nonhuman primates
    Astrid Paneda
    Division of Hepatology and Gene Therapy, Center for Applied Medical Research CIMA, 31008 Pamplona, Spain
    Hum Gene Ther 22:999-1009. 2011
    ..However, we also describe how an immune response against HSV-TK hampered analysis of long-term expression in nonhuman primates...
  17. doi request reprint Dual tracer 11C-choline and FDG-PET in the diagnosis of biochemical prostate cancer relapse after radical treatment
    Jose A Richter
    Nuclear Medicine Department, Clinica Universitaria, Universidad de Navarra, Avenida Pio XII 36, Pamplona, Spain
    Mol Imaging Biol 12:210-7. 2010
    ..The purpose of this study was to evaluate a dual tracer 2-deoxy-2-[F-18]fluoro-D: -glucose (FDG) and (11)C-choline positron emission tomography (PET) protocol in the detection of biochemical prostate cancer relapse...
  18. ncbi request reprint Dendritic cells delivered inside human carcinomas are sequestered by interleukin-8
    Esperanza Feijoo
    Division of Hepatology and Gene Therapy, Clinica Universitaria School of Medicine, Foundation for Applied Medical Research, Universidad de Navarra, Pamplona, Spain
    Int J Cancer 116:275-81. 2005
    ..Impairment of DC migration toward lymphoid tissue could be involved in cancer immune evasion...
  19. doi request reprint Statistical parametric maps of ¹⁸F-FDG PET and 3-D autoradiography in the rat brain: a cross-validation study
    Elena Prieto
    Nuclear Medicine Department, Clinica Universidad de Navarra, Av Pio XII 36, 31008 Pamplona, Spain
    Eur J Nucl Med Mol Imaging 38:2228-37. 2011
    ..The gold standard for the validation of the PET results was the autoradiography of the same animals acquired under the same physiological conditions, reconstructed as a 3-D volume and analysed using SPM...
  20. doi request reprint Design and performance evaluation of single-use whole-sterile "plug & play" kits for routine automated production of [(11)C]choline and [(11)C]methionine with radiopharmaceutical quality
    Gemma Quincoces
    Radiopharmacy Unit, Department of Nuclear Medicine, University Hospital, University of Navarra School of Medicine, Av Pio XII 36, 31008 Pamplona, Spain
    Appl Radiat Isot 68:2298-301. 2010
    ..The use of all-disposable sterile medical-grade material, helps ensure safety and cGMP compliance. The quick set-up and removal ("plug & play") also reduces radiation burden to operator...
  21. doi request reprint Toxicity studies of poly(anhydride) nanoparticles as carriers for oral drug delivery
    Patricia Ojer
    Department of Pharmacy and Pharmaceutical Technology, University of Navarra, C Irunlarrea, 1, Pamplona 31008, Spain
    Pharm Res 29:2615-27. 2012
    ..To evaluate the acute and subacute toxicity of poly(anhydride) nanoparticles as carriers for oral drug/antigen delivery...
  22. doi request reprint Decreased carbon-11-flumazenil binding in early Alzheimer's disease
    Belen Pascual
    Neuroscience Division, Centre for Applied Medical Research, University of Navarra, Pamplona, 31008, Spain
    Brain 135:2817-25. 2012
    ..From these data, we conclude that [(11)C]-flumazenil binding could be a useful marker of neuronal loss in early Alzheimer's disease...
  23. doi request reprint Impact of time-of-flight and point-spread-function in SUV quantification for oncological PET
    Elena Prieto
    Department of Nuclear Medicine, Clinica Universidad de Navarra, Pamplona, Spain
    Clin Nucl Med 38:103-9. 2013
    ..However, first experiences with these techniques have shown a consistent tendency to measure markedly high SUV values, bewildering nuclear medicine physicians and referring clinicians...
  24. doi request reprint Cyclodextrin-poly(anhydride) nanoparticles as new vehicles for oral drug delivery
    Maite Agüeros
    University of Navarra, School of Pharmacy, Department of Pharmaceutics and Pharmaceutical Technology, Pamplona, Spain
    Expert Opin Drug Deliv 8:721-34. 2011
    ..Among other types of drug, various anti-cancer drugs also suffer from these drawbacks (i.e., paclitaxel), which limits the possibilities for developing oral treatments...
  25. doi request reprint Twelve automated thresholding methods for segmentation of PET images: a phantom study
    Elena Prieto
    Department of Nuclear Medicine, Clinica Universidad de Navarra, Pio XII 36, 31008 Pamplona, Spain
    Phys Med Biol 57:3963-80. 2012
    ..05). We have herein demonstrated that fully automated thresholding algorithms can provide better results than classical PET segmentation tools...
  26. doi request reprint Progression of dopaminergic depletion in a model of MPTP-induced Parkinsonism in non-human primates. An (18)F-DOPA and (11)C-DTBZ PET study
    Javier Blesa
    Movement Disorders Group, Neurosciences Division, CIMA, and Department of Neurology and Neurosurgery, Clinica Universidad de Navarra, Pamplona, Spain
    Neurobiol Dis 38:456-63. 2010
    ..This approach could be useful to perform studies aiming to test the effect of early therapeutic intervention and putative neuroprotective treatments...
  27. doi request reprint Agonist anti-CD137 mAb act on tumor endothelial cells to enhance recruitment of activated T lymphocytes
    Asis Palazon
    CIMA and CUN University of Navarra, Pamplona, Spain
    Cancer Res 71:801-11. 2011
    ..Our findings identify an additional mechanism of action that can explain the immunotherapeutic effects of agonist CD137 antibodies...
  28. ncbi request reprint Activation of human cerebral and cerebellar cortex by auditory stimulation at 40 Hz
    Maria A Pastor
    Department of Neurology, University of Navarra School of Medicine, 31080 Pamplona, Spain
    J Neurosci 22:10501-6. 2002
    ..Additionally, we found that, compared with other stimulation frequencies, 40 Hz selectively activated the auditory region of the pontocerebellum, a brain structure with important roles in cortical inhibition and timing...
  29. ncbi request reprint [Use of 11C-(+)-alpha -dihydrotetrabenazine for the assessment of dopaminergic innervation in animal models of Parkinson's disease]
    M Collantes
    Unidad de Investigación microPET, Centro de Investigación Médica Aplicada CIMA Clínica Universitaria de Navarra, Pamplona, Espana
    Rev Esp Med Nucl 27:103-11. 2008
    ....
  30. doi request reprint A phase I clinical trial of thymidine kinase-based gene therapy in advanced hepatocellular carcinoma
    B Sangro
    Liver Unit, Clinica Universitaria, Pamplona, Spain
    Cancer Gene Ther 17:837-43. 2010
    ..One of them achieved a sustained stabilization and survived for 26 months. In conclusion, Ad.TK can be safely administered by intratumoral injection to patients with HCC up to 2 × 10¹² vp per patient...
  31. ncbi request reprint [Quick and simple synthesis of (11)C-(+)-alpha-dihydrotetrabenazine to be used as a PET radioligand of vesicular monoamine transporters]
    G Quincoces
    Unidad de Radiofarmacia, Servicio de Medicina Nuclear, Clinica Universitaria de Navarra, Pamplona, Navarra, Spain
    Rev Esp Med Nucl 27:13-21. 2008
    ....
  32. doi request reprint New MRI, 18F-DOPA and 11C-(+)-alpha-dihydrotetrabenazine templates for Macaca fascicularis neuroimaging: advantages to improve PET quantification
    M Collantes
    Small Animal Imaging Research Unit, Center for Applied Medical Research CIMA and Clínica Universidad de Navarra, Pamplona, Spain
    Neuroimage 47:533-9. 2009
    ..In conclusion, templates of M. fascicularis brain have been constructed and validated for reproducible and automated PET quantification. All templates are electronically available via the internet...
  33. ncbi request reprint [Use of a cyclotron in the production of positron emitting radionuclides]
    J Marti-Climent
    Servicio de Medicina Nuclear, Clinica Universitaria de Navarra, Pamplona, Navarra, 31008, Espana
    Rev Esp Med Nucl 18:261-7. 1999
    ....
  34. ncbi request reprint Functional neuroanatomy of sustained attention in schizophrenia: contribution of parietal cortices
    Natalia Ojeda
    Department of Psychiatry and Medical Psychology, University Hospital School of Medicine, University of Navarre, Avda Pio XII, Pamplona, Navarre, Spain
    Hum Brain Mapp 17:116-30. 2002
    ..They failed to activate prefrontal and parietal regions at a similar level during tasks requiring increased cognitive effort, and they required a higher activation of inferior frontal regions to properly respond to cognitive demands...
  35. pmc Intensive pharmacological immunosuppression allows for repetitive liver gene transfer with recombinant adenovirus in nonhuman primates
    Antonio Fontanellas
    Gene Therapy and Hepatology Area, Centre for Applied Medical Research, University of Navarra, Pamplona, Spain
    Mol Ther 18:754-65. 2010
    ..This strategy allows measurable gene retransfer to the liver as late as 15 months following the first adenoviral exposure in a macaque, which has undergone a total of four treatments with the same adenoviral vector...
  36. doi request reprint Pilot clinical trial of type 1 dendritic cells loaded with autologous tumor lysates combined with GM-CSF, pegylated IFN, and cyclophosphamide for metastatic cancer patients
    Carlos Alfaro
    Gene Therapy and Hepatology Unit, Center for Applied Medical Research, University of Navarra, 31008 Pamplona, Spain
    J Immunol 187:6130-42. 2011
    ..This combinatorial immunotherapy strategy is safe and feasible, and its immunobiological effects suggest potential activity in patients with minimal residual disease. A randomized trial exploring this hypothesis is currently ongoing...
  37. doi request reprint Levodopa induces long-lasting modification in the functional activity of the nigrostriatal pathway
    Mario Riverol
    Department of Neurology, Clinica Universidad de Navarra, Pamplona, Spain Laboratory of Regenerative Therapy, Center for Applied Medical Research CIMA, Pamplona, Spain
    Neurobiol Dis 62:250-9. 2014
    ..This study shows that chronic levodopa administration to monkeys with partial nigrostriatal degeneration followed by a washout period induces modifications in the functional activity of the dopaminergic nigrostriatal pathway. ..
  38. pmc Antitumor and antiangiogenic effect of the dual EGFR and HER-2 tyrosine kinase inhibitor lapatinib in a lung cancer model
    Roque Diaz
    Division of Oncology, Center for Applied Medical Research CIMA, University of Navarra, Pamplona, Spain
    BMC Cancer 10:188. 2010
    ..In this report, we investigated the activity of lapatinib against non-small cell lung cancer (NSCLC)...
  39. ncbi request reprint A synthetic peptide from transforming growth factor beta type III receptor inhibits liver fibrogenesis in rats with carbon tetrachloride liver injury
    Ignacio José Ezquerro
    Departamento de Medicina Interna, Universidad de Navarra, Pamplona, Spain
    Cytokine 22:12-20. 2003
    ..These results suggest that short synthetic peptides derived from TGF-beta1 type III receptor may be of value in reducing liver fibrosis in chronic liver injury...
  40. pmc Deletion of inducible nitric-oxide synthase in leptin-deficient mice improves brown adipose tissue function
    Sara Becerril
    Metabolic Research Laboratory, Clinica Universidad de Navarra, Pamplona, Spain
    PLoS ONE 5:e10962. 2010
    ..Therefore, the aim of the present study was to analyze the impact of the absence of the inducible NO synthase (iNOS) gene in the regulation of energy balance in ob/ob mice...
  41. doi request reprint Transplantation of adipose derived stromal cells is associated with functional improvement in a rat model of chronic myocardial infarction
    Manuel Mazo
    Hematology and Cell Therapy and Foundation for Applied Medical Research, Division of Cancer, University of Navarra, Pamplona, Spain
    Eur J Heart Fail 10:454-62. 2008
    ..To determine the effect of transplantation of undifferentiated and cardiac pre-differentiated adipose stem cells compared with bone marrow mononuclear cells (BM-MNC) in a chronic model of myocardial infarction...
  42. doi request reprint Bioadhesive properties and biodistribution of cyclodextrin-poly(anhydride) nanoparticles
    Maite Agüeros
    Department of Pharmacy and Pharmaceutical Technology, University of Navarra, Apartado 177, 31008 Pamplona, Spain
    Eur J Pharm Sci 37:231-40. 2009
    ..Finally, from in vivo studies, no evidence of translocation of distribution to other organs was observed when these nanoparticles were orally administered...
  43. doi request reprint PET imaging of thymidine kinase gene expression in the liver of non-human primates following systemic delivery of an adenoviral vector
    A Fontanellas
    Division of Gene Therapy and Hepatology, Centre for Applied Medical Research, University of Navarra, Pamplona, Spain
    Gene Ther 16:136-41. 2009
    ..Such imaging methodology might contribute to improve strategies based on adenoviral vectors...
  44. ncbi request reprint Sustained attention in a counting task: normal performance and functional neuroanatomy
    F Ortuno
    Department of Psychiatry and Medical Psychology, University Hospital, School of Medicine, University of Navarra, Pamplona, Navarre, Spain
    Neuroimage 17:411-20. 2002
    ..The findings obtained in this study support the notion that the parietal and dorsolateral prefrontal cortex are involved when time estimation and working memory are taking part in a task requiring sustained attention...