Jose A Paramo

Summary

Affiliation: University of Navarra
Country: Spain

Publications

  1. pmc Integrating soluble biomarkers and imaging technologies in the identification of vulnerable atherosclerotic patients
    Jose A Paramo
    Atherosclerosis Research, Division of Cardiovascular Sciences, CIMA, University of Navarra, Pamplona, Spain
    Biomark Insights 1:165-73. 2007
  2. doi request reprint Tissue factor expressed by microparticles is associated with mortality but not with thrombosis in cancer patients
    C Hernandez
    José A Páramo, Servicio de Hematologia, Clinica Universidad de Navarra, Av Pio XII, 36, 31008 Pamplona, Navarra, Spain, Tel 34 948 296397, Fax 34 948 296500, E mail
    Thromb Haemost 110:598-608. 2013
  3. pmc Association between serum soluble CD40 ligand levels and mortality in patients with severe sepsis
    Leonardo Lorente
    Intensive Care Unit, Hospital Universitario de Canarias, Ofra, S N, La Laguna 38320, Santa Cruz de Tenerife, Spain
    Crit Care 15:R97. 2011
  4. pmc Matrix metalloproteinase-9, -10, and tissue inhibitor of matrix metalloproteinases-1 blood levels as biomarkers of severity and mortality in sepsis
    Leonardo Lorente
    Intensive Care Unit, Hospital Universitario de Canarias, Ofra, 38320 Santa Cruz de Tenerife, Spain
    Crit Care 13:R158. 2009
  5. ncbi request reprint Fibrinolysis/proteolysis balance in stable angina pectoris in relation to angiographic findings
    J A Paramo
    Atherosclerosis Research Unit, Division of Cardiovascular Pathophysiology and Biochemistry, University of Navarra, Pamplona, Spain
    Thromb Haemost 86:636-9. 2001
  6. ncbi request reprint [Arterial thrombosis and genetic polymorphisms: too many actors, complex scenario]
    Jose A Paramo
    Servicio de Hematologia, Clinica Universitaria de Navarra, Pamplona, Spain
    Med Clin (Barc) 124:69-74. 2005
  7. ncbi request reprint Independent association of von Willebrand factor with surrogate markers of atherosclerosis in middle-aged asymptomatic subjects
    J A Paramo
    Atherosclerosis Research, University Clinical, School of Medicine, University of Navarra, Pamplona, Spain
    J Thromb Haemost 3:662-4. 2005
  8. ncbi request reprint [Association of age, inflammatory markers and subclinical atherosclerosis in subjects free from cardiovascular disease]
    Jose A Paramo
    Area de Ciencias Cardiovasculares, Centro de Investigación Médica Aplicada CIMA, Universidad de Navarra, Pamplona, Navarra, Espana
    Med Clin (Barc) 131:361-6. 2008
  9. ncbi request reprint Monocyte cyclooxygenase-2 activity: a new therapeutic target for atherosclerosis?
    J A Paramo
    Atherosclerosis Research, Centre for Applied Medical Research, 31008 Pamplona, Navarra, Spain
    Curr Drug Targets Cardiovasc Haematol Disord 5:303-11. 2005
  10. ncbi request reprint Vulnerable plaque versus vulnerable patient: emerging blood biomarkers for risk stratification
    J A Paramo
    Atherosclerosis Research, Division of Cardiovascular Sciences, CIMA, University of Navarra, Pamplona, Avda Pio XII 55 31008 Pamplona, Spain
    Endocr Metab Immune Disord Drug Targets 7:195-201. 2007

Collaborators

Detail Information

Publications57

  1. pmc Integrating soluble biomarkers and imaging technologies in the identification of vulnerable atherosclerotic patients
    Jose A Paramo
    Atherosclerosis Research, Division of Cardiovascular Sciences, CIMA, University of Navarra, Pamplona, Spain
    Biomark Insights 1:165-73. 2007
    ..However, additional studies are required in order to show that this approach can contribute to improved diagnostic and therapeutic of atherosclerotic disease...
  2. doi request reprint Tissue factor expressed by microparticles is associated with mortality but not with thrombosis in cancer patients
    C Hernandez
    José A Páramo, Servicio de Hematologia, Clinica Universidad de Navarra, Av Pio XII, 36, 31008 Pamplona, Navarra, Spain, Tel 34 948 296397, Fax 34 948 296500, E mail
    Thromb Haemost 110:598-608. 2013
    ..In conclusion, while TF variables were not associated with future VTE in cancer patients, we found a strong association of TF and MPs-TF activity with mortality, thus suggesting they might be good prognostic markers in cancer patients. ..
  3. pmc Association between serum soluble CD40 ligand levels and mortality in patients with severe sepsis
    Leonardo Lorente
    Intensive Care Unit, Hospital Universitario de Canarias, Ofra, S N, La Laguna 38320, Santa Cruz de Tenerife, Spain
    Crit Care 15:R97. 2011
    ..Thus, the aim of this study was to determine whether circulating sCD40L levels could be a marker of adverse outcome in a large cohort of patients with severe sepsis...
  4. pmc Matrix metalloproteinase-9, -10, and tissue inhibitor of matrix metalloproteinases-1 blood levels as biomarkers of severity and mortality in sepsis
    Leonardo Lorente
    Intensive Care Unit, Hospital Universitario de Canarias, Ofra, 38320 Santa Cruz de Tenerife, Spain
    Crit Care 13:R158. 2009
    ..The objective of this study was to determine the predictive value of MMP-9, MMP-10, and TIMP-1 on clinical severity and mortality in a large series of patients with severe sepsis...
  5. ncbi request reprint Fibrinolysis/proteolysis balance in stable angina pectoris in relation to angiographic findings
    J A Paramo
    Atherosclerosis Research Unit, Division of Cardiovascular Pathophysiology and Biochemistry, University of Navarra, Pamplona, Spain
    Thromb Haemost 86:636-9. 2001
    ..We conclude that there is a disturbance of the plasma fibrinolysis/proteolysis in patients with stable angina not related to the extent of atherosclerosis. The t-PA levels may be a good marker for coronary occlusion in these patients...
  6. ncbi request reprint [Arterial thrombosis and genetic polymorphisms: too many actors, complex scenario]
    Jose A Paramo
    Servicio de Hematologia, Clinica Universitaria de Navarra, Pamplona, Spain
    Med Clin (Barc) 124:69-74. 2005
    ..Whereas the individual contribution of each polymorphism to the overall cardiovascular risk seems to be modest, multiple gene-gene and gene-environment interactions appear more relevant in the pathogenesis of arterial thrombosis...
  7. ncbi request reprint Independent association of von Willebrand factor with surrogate markers of atherosclerosis in middle-aged asymptomatic subjects
    J A Paramo
    Atherosclerosis Research, University Clinical, School of Medicine, University of Navarra, Pamplona, Spain
    J Thromb Haemost 3:662-4. 2005
    ..01). In conclusion, VWF was independently associated with both structural and functional surrogates of atherosclerosis in asymptomatic subjects, thus representing a systemic biomarker of subclinical atherosclerosis...
  8. ncbi request reprint [Association of age, inflammatory markers and subclinical atherosclerosis in subjects free from cardiovascular disease]
    Jose A Paramo
    Area de Ciencias Cardiovasculares, Centro de Investigación Médica Aplicada CIMA, Universidad de Navarra, Pamplona, Navarra, Espana
    Med Clin (Barc) 131:361-6. 2008
    ..We assessed whether an independent association between inflammatory markers and age-related subclinical atherosclerosis could be found in subjects free from cardiovascular disease...
  9. ncbi request reprint Monocyte cyclooxygenase-2 activity: a new therapeutic target for atherosclerosis?
    J A Paramo
    Atherosclerosis Research, Centre for Applied Medical Research, 31008 Pamplona, Navarra, Spain
    Curr Drug Targets Cardiovasc Haematol Disord 5:303-11. 2005
    ....
  10. ncbi request reprint Vulnerable plaque versus vulnerable patient: emerging blood biomarkers for risk stratification
    J A Paramo
    Atherosclerosis Research, Division of Cardiovascular Sciences, CIMA, University of Navarra, Pamplona, Avda Pio XII 55 31008 Pamplona, Spain
    Endocr Metab Immune Disord Drug Targets 7:195-201. 2007
    ..A multimarker approach to estimate cardiovascular risk either by inflammatory markers and cumulative risk markers obtained from non-invasive tests or both may be superior to assessing a single marker...
  11. ncbi request reprint [Treatment of antiphospholipid syndrome]
    J A Paramo
    Servicio de Hematologia, Clinica Universitaria, Facultad de Medicina, Universidad de Navarra, Pamplona
    Rev Med Univ Navarra 51:38-41. 2007
    ..Patients with APS are treated with long-term therapy to prolong the INR to 2.0-3.0. Low-molecular-weight heparin in combination with low-aspirin dose is a reasonable strategy to avoid pregnancy loss in women with this syndrome...
  12. ncbi request reprint [Atherosclerosis in inflammatory diseases]
    Jose A Paramo
    Servicio de Hematologia y Hemoterapia, Clinica Universitaria, Pamplona, Navarra, Espana
    Med Clin (Barc) 128:749-56. 2007
    ....
  13. ncbi request reprint [Antiplatelets and anticoagulants in acute coronary syndromes: levels of evidence]
    J A Paramo
    Servicio de Hematologia, Clínica Universitaria Facultad de Medicina, Universidad de Navarra, Espana
    Rev Med Univ Navarra 51:23-7. 2007
    ..As new treatments are rapidly added, clinicians are constantly challenged to incorporate new information and guidelines into their practices in a timely fashion...
  14. ncbi request reprint [To whom should a study of thrombophilia be performed?]
    Jose A Paramo
    Servicio de Hematologia, Clinica Universitaria, Universidad de Navarra, Pamplona, Navarra, Espana
    Med Clin (Barc) 128:665-7. 2007
  15. ncbi request reprint Association between matrix metalloproteinase-10 concentration and smoking in individuals without cardiovascular disease
    Jose A Paramo
    Area de Ciencias Cardiovasculares, CIMA, Universidad de Navarra, Pamplona, Navarra, Spain
    Rev Esp Cardiol 61:1267-73. 2008
    ..The aim of this study was to determine whether there is an independent association between smoking and the concentration of circulating metalloproteinases (MMPs) in individuals without cardiovascular disease...
  16. doi request reprint [Venous thromboembolism: an urgent call for action]
    Jose A Paramo
    Servicio de Hematologia, Clinica Universidad de Navarra, Pamplona, Espana
    Med Clin (Barc) 133:547-51. 2009
    ..The commitment of all levels of governments as well as public and private institutions will be crucial to reduce the incidence of DVT, a leading cause of death...
  17. ncbi request reprint Hemostasis, inflammation and cardiovascular disease
    Jose A Paramo
    Division of Cardiovascular Pathophysiology, University of Navarra, Pamplona, Spain
    Clin Lab 48:463-70. 2002
  18. ncbi request reprint Prothrombin fragments in cardiovascular disease
    J A Paramo
    Hematology Service, University Clinic, Atherosclerosis Research, CIMA, University of Navarra, Pamplona, Spain
    Adv Clin Chem 51:1-23. 2010
    ..Finally, the prognostic value of F1+2 and other markers of coagulation activation remains to be fully defined in future studies...
  19. doi request reprint [New era in antiplatelet therapy based on results from recent clinical trials]
    José Antonio Páramo
    Servicio de Hematologia, Clinica Universidad de Navarra, Pamplona, Navarra, Spain
    Med Clin (Barc) 137:504-8. 2011
    ..These new agents open a realistic prospect of a personalized choice of the most appropriate antiplatelet therapy tailored for an individual patient and a clinical condition...
  20. ncbi request reprint [Diagnosis and management of deep venous thrombosis]
    J A Paramo
    Servicio de Hematologia, Clinica Universitaria, Facultad de Medicina, Universidad de Navarra, Espana
    Rev Med Univ Navarra 51:13-7. 2007
    ..Interventions such as thrombolysis and placement of inferior vena cava filter are reserved for special situations...
  21. ncbi request reprint [Atheroma plaque stabilization: a new concept based on the dynamic biology of atherosclerosis]
    Jose A Paramo
    Laboratorio de Aterosclerosis División de Fisiopatología Cardiovascular Facultad de Medicina Universidad de Navarra Pamplona España
    Med Clin (Barc) 121:583-7. 2003
    ....
  22. ncbi request reprint [Clinical complications in a series of patients with anticardiolipin antibodies]
    A Pujol
    Facultad de Medicina, Clinica Universitaria de Navarra, Pamplona, 31008, Spain
    An Sist Sanit Navar 26:365-72. 2003
    ..In the series of patients with ACA IgG>23 GPL, we appreciated a high percentage of venous and arterial thrombosis detected with objective methods. The presence of ACA constitutes a prothrombotic risk factor..
  23. ncbi request reprint [Pharmacological alternatives to blood transfusion: what is new about?]
    Jose A Paramo
    Servicio de Hematologia, Clinica Universitaria de Navarra, Pamplona, Espana
    Med Clin (Barc) 122:231-6. 2004
    ..Hematopoietic cytokines, such as EPO, may have a place to avoid blood transfusion in a variety of clinical conditions, including cancer and critically ill patients...
  24. ncbi request reprint Prothrombin fragment 1+2 is associated with carotid intima-media thickness in subjects free of clinical cardiovascular disease
    J A Paramo
    Atherosclerosis Research, University Clinic, School of Medicine, University of Navarra, Pamplona, Spain
    Stroke 35:1085-9. 2004
    ..We studied the relationship between prothrombin fragment 1+2 (F1+2), a specific marker of thrombin generation in vivo, and carotid intima-media thickness (IMT), an index of subclinical atherosclerosis...
  25. doi request reprint [Hemorrhage, hemostasis and thrombosis in surgery]
    Jose A Paramo
    Servicio de Hematologia, Clinica Universidad de Navarra, Pamplona, Espana
    Cir Esp 85:2-6. 2009
    ..To prevent postoperative thrombosis, low molecular weight heparins or pentasaccharide have been shown to significantly reduce the incidence of thromboembolism...
  26. ncbi request reprint [Disseminated intravascular coagulation]
    Jose A Paramo
    Servicio de Hematologia, Clinica Universitaria, Universidad de Navarra, Pamplona, Navarra, Espana
    Med Clin (Barc) 127:785-9. 2006
  27. doi request reprint Matrix metalloproteinase-10 is upregulated by thrombin in endothelial cells and increased in patients with enhanced thrombin generation
    Josune Orbe
    Atherothrombosis Research Laboratory, Division of Cardiovascular Science, Center for Applied Medical Research CIMA University of Navarra, Pamplona, Spain
    Arterioscler Thromb Vasc Biol 29:2109-16. 2009
    ..Thrombin is a multifunctional serine protease that promotes vascular proinflammatory responses whose effect on endothelial MMP-10 expression has not previously been evaluated...
  28. ncbi request reprint Vitamins C and E downregulate vascular VEGF and VEGFR-2 expression in apolipoprotein-E-deficient mice
    Beatriz Nespereira
    Atherosclerosis Research Unit, University of Navarra, C Irunlarrea 1 CIFA, Pamplona E 31008, Spain
    Atherosclerosis 171:67-73. 2003
    ..This novel mechanism could contribute to explaining the beneficial effects of antioxidant vitamins in experimental atherosclerosis...
  29. doi request reprint Synergistic effect of thrombin and CD40 ligand on endothelial matrix metalloproteinase-10 expression and microparticle generation in vitro and in vivo
    Sara Martinez de Lizarrondo
    Laboratory of Atherothrombosis, Division of Cardiovascular Sciences, CIMA, Av Pio XII, 55, 31008 Pamplona, Navarra, Spain
    Arterioscler Thromb Vasc Biol 32:1477-87. 2012
    ..Thrombin induces CD40 ligand (CD40L) and matrix metalloproteinases (MMPs) under inflammatory/prothrombotic conditions. Thrombin and CD40L could modulate endothelial MMP-10 expression in vitro and in vivo...
  30. ncbi request reprint Monocyte cyclooxygenase-2 overactivity: a new marker of subclinical atherosclerosis in asymptomatic subjects with cardiovascular risk factors?
    Oscar Beloqui
    Department of Internal Medicine, University Clinic, Clinica Universitaria, Avenida de Pio XII 36, 31008 Pamplona, Spain
    Eur Heart J 26:153-8. 2005
    ..We investigated the relationship between COX-2-mediated prostaglandin-E2 (PGE2) release, cardiovascular risk factors, and carotid atherosclerosis in apparently healthy subjects...
  31. ncbi request reprint Dietary supplementation with vitamins C and E prevents downregulation of endothelial NOS expression in hypercholesterolemia in vivo and in vitro
    Jose A Rodriguez
    Atherosclerosis Research Laboratory, Division of Cardiovascular Pathophysiology, School of Medicine, University of Navarra, C Irunlarrea 1, CIFA, 31008, Pamplona, Spain
    Atherosclerosis 165:33-40. 2002
    ..A similar effect could be demonstrated in vitro, by incubation of EC with native LDL, suggesting that the effect of physiologically-modified LDL on eNOS could have a role in recovering vascular function...
  32. doi request reprint Increased thrombin generation after acute versus chronic coronary disease as assessed by the thrombin generation test
    Josune Orbe
    Atherosclerosis Research Laboratory, Division of Cardiovascular Sciences, CIMA, University of Navarra, Avda Pio XII 55, Pamplona, Spain
    Thromb Haemost 99:382-7. 2008
    ..The thrombin generation test may be of clinical value to monitor hypercoagulable/vulnerable blood and/or guide therapy in CAD...
  33. ncbi request reprint Validation of plasma fibrinogen as a marker of carotid atherosclerosis in subjects free of clinical cardiovascular disease
    Jose A Paramo
    Atherosclerosis Research, Area of Cardiovascular Pathophysiology, Clinica Universitaria, Pamplona, Spain
    Haematologica 89:1226-31. 2004
    ..The aim of this study was to validate the measurement of plasma fibrinogen as a marker of subclinical atherosclerosis in a series of asymptomatic subjects (n=519, median age 55.5 years, 80% men)...
  34. doi request reprint [Clinical use of D-dimer in patients with cancer]
    Ramon Lecumberri
    Servicio de Hematologia, Clinica Universidad de Navarra, Pamplona, Spain
    Med Clin (Barc) 137:453-8. 2011
    ..In this review, the current evidence supporting the use of DD in cancer patients is critically exposed and discussed...
  35. ncbi request reprint Independent association of fibrinogen with carotid intima-media thickness in asymptomatic subjects
    Eduardo Martinez-Vila
    Vascular Risk Area, University Clinic, Pamplona, Spain
    Cerebrovasc Dis 16:356-62. 2003
    ..Therefore, the aim of this study was to investigate the relations of plasma fibrinogens and the -455 G/A Bbeta-fibrinogen polymorphism with the carotid IMT in a series of asymptomatic subjects...
  36. ncbi request reprint Metalloproteinases and atherothrombosis: MMP-10 mediates vascular remodeling promoted by inflammatory stimuli
    Jose A Rodriguez
    Atherosclerosis Research Laboratory, Division of Cardiovascular Sciences CIMA University of Navarra Avda Pio XII 55, 31008 Pamplona, Spain
    Front Biosci 13:2916-21. 2008
    ....
  37. ncbi request reprint C-reactive protein induces matrix metalloproteinase-1 and -10 in human endothelial cells: implications for clinical and subclinical atherosclerosis
    Ines Montero
    Laboratory of Atherosclerosis, School of Medicine University Clinic, Center for Applied Medical Research, University of Navarra, Pamplona, Spain
    J Am Coll Cardiol 47:1369-78. 2006
    ..We examined the effect of C-reactive protein (CRP) on matrix metalloproteinase (MMP) and inhibitor expression in endothelial cells and in patients with clinical and subclinical atherosclerosis...
  38. ncbi request reprint [Fibrinogen. An old hemostatic protein with a new function: non-invasive marker of subclinical atherosclerosis]
    Jose A Paramo
    Laboratorio de Aterosclerosis, Servicio de Hematologia, Clinica Universitaria, Universidad de Navarra, Pamplona, Espana
    Med Clin (Barc) 124:790-4. 2005
    ..Likewise, recent studies from our group have shown that increased fibrinogen levels represent a marker of subclinical atherosclerosis, likely to be useful in the identification of asymptomatic subjects at risk for cardiovascular disease...
  39. doi request reprint High incidence of venous thromboembolism despite electronic alerts for thromboprophylaxis in hospitalised cancer patients
    Ramon Lecumberri
    Hematology Service, University Clinic of Navarra, Av Pio XII, 36, 31008 Pamplona, Spain
    Thromb Haemost 110:184-90. 2013
    ..Contrary to the impact on hospitalised patients without cancer, implementation of e-alerts for VTE risk did not prevent VTE effectively among those with malignancies. ..
  40. ncbi request reprint Different expression of MMPs/TIMP-1 in human atherosclerotic lesions. Relation to plaque features and vascular bed
    J Orbe
    Atherosclerosis Research Laboratory, Division of Cardiovascular Pathophysiology, School of Medicine, University of Navarra, C Irunlarrea 1, 31008 Pamplona, Spain
    Atherosclerosis 170:269-76. 2003
    ..The aim of this study was to examine differences in the patterns of metalloproteinases (MMPs) and MMP inhibitor (TIMP-1) expression in advanced human atheromas, both in relation to the plaque features and the vascular bed involved...
  41. ncbi request reprint The A1166C polymorphism of the AT1 receptor gene is associated with collagen type I synthesis and myocardial stiffness in hypertensives
    Javier Diez
    Division of Cardiovascular Pathophysiology, Centre for Applied Medical Research, School of Medicine, University of Navarra, Pamplona, Spain
    J Hypertens 21:2085-92. 2003
    ..We have investigated whether the A1166C polymorphism of the angiotensin II type 1 (AT1) receptor gene modulates the effects of angiotensin II on collagen type I turnover and myocardial stiffness in hypertension...
  42. ncbi request reprint Anticoagulant treatment and survival in cancer patients. The evidence from clinical studies
    Ramon Lecumberri
    Hematology Service, University Clinic of Navarra, University of Navarra, Pamplona, Spain
    Haematologica 90:1258-66. 2005
    ....
  43. ncbi request reprint [Decreased transfusion requirements in acquired severe bleeding with recombinant activated factor VII]
    Ramon Lecumberri
    Servicio de Hematologia, Clinica Universitaria de Navarra, Pamplona, Navarra, Spain
    Med Clin (Barc) 125:252-3. 2005
    ..The aim of the study was to evaluate the role of rFVIIa in the management of severe bleeding, refractory to other treatments...
  44. doi request reprint Association between matrix metalloproteinase-10 concentration and smoking in individuals without cardiovascular disease
    Jose A Paramo
    División of Cardiovascular Sciencies, Center for Applied Medical Research, University of Navarra, Pamplona, Navarra, Spain
    Rev Esp Cardiol (Engl Ed) 61:1267-73. 2008
    ..The aim of this study was to determine whether there is an independent association between smoking and the concentration of circulating metalloproteinases (MMPs) in individuals without cardiovascular disease...
  45. doi request reprint Screening for occult malignancy with FDG-PET/CT in patients with unprovoked venous thromboembolism
    Ana Alfonso
    Hematology Service, Clinica Universidad de Navarra, Pamplona, Spain
    Int J Cancer 133:2157-64. 2013
    ..FDG-PET/CT is feasible for the screening of occult cancer in patients with unprovoked VTE, showing high S and NPV. The addition of TF activity determination may be useful for patient selection. ..
  46. ncbi request reprint Involvement of leptin in the association between percentage of body fat and cardiovascular risk factors
    Javier Gomez-Ambrosi
    Metabolic Research Laboratory, Clinica Universitaria de Navarra, Pamplona, Spain
    Clin Biochem 35:315-20. 2002
    ..We have assessed whether these markers are associated with percentage of body fat (BF), insulin sensitivity as well as with leptin concentrations...
  47. ncbi request reprint Preliminary characterisation of the promoter of the human p22(phox) gene: identification of a new polymorphism associated with hypertension
    Maria U Moreno
    Division of Cardiovascular Pathophysiology, Centre for Applied Medical Research, School of Medicine, University of Navarra, C Irunlarrea 1, 31008 Pamplona, Spain
    FEBS Lett 542:27-31. 2003
    ..Mutagenesis experiments showed that the G allele had higher promoter activity than the A allele. These results suggest that the -930(A/G) polymorphism in the p22(phox) promoter may be a novel genetic marker associated with hypertension...
  48. ncbi request reprint [Cyclooxygenase-2: a new therapeutic target in atherosclerosis?]
    Jose A Paramo
    Servicio de Hematologia, Laboratorio de Aterosclerosis, Centro para la Investigación Médica Aplicada CIMA, Clinica Universitaria, Universidad de Navarra, Pamplona, Navarra, Espana
    Med Clin (Barc) 126:782-6. 2006
    ....
  49. doi request reprint Angiogenic and prothrombotic markers in extensive slow-flow vascular malformations: implications for antiangiogenic/antithrombotic strategies
    P Redondo
    Department of Dermatology, University Clinic of Navarra, 31008 Pamplona, Spain
    Br J Dermatol 162:350-6. 2010
    ..Localized intravascular coagulation associated with venous or combined malformations is characterized by low fibrinogen, high D-dimers, and normal platelet count...
  50. ncbi request reprint The 4G/5G PAI-1 polymorphism influences the endothelial response to IL-1 and the modulatory effect of pravastatin
    C Roncal
    Atherosclerosis Research Laboratory, Division of Cardiovascular Sciences, Centre for Applied Medical Research, University of Navarra, Pamplona, Spain
    J Thromb Haemost 4:1798-803. 2006
    ..PAI-1 expression may be regulated by different inflammatory cytokines such as interleukin-1alpha (IL-1). Several polymorphisms have been described in the PAI-1 gene...
  51. ncbi request reprint [Metalloproteases, vascular remodeling and atherothrombotic syndromes]
    Jose A Rodriguez
    Laboratorio de Aterosclerosis, Area de Ciencias Cardiovasculares, CIMA Universidad de Navarra, Pamplona, Espana
    Rev Esp Cardiol 60:959-67. 2007
    ....
  52. ncbi request reprint Vitamins C and E prevent endothelial VEGF and VEGFR-2 overexpression induced by porcine hypercholesterolemic LDL
    Jose A Rodriguez
    Atherosclerosis Research Laboratory, Division of Cardiovascular Pathophysiology, School of Medicine, Foundation for Applied Medical Research, University of Navarra, Pamplona Navarra E 31008, Spain
    Cardiovasc Res 65:665-73. 2005
    ....
  53. doi request reprint MMP-10 is required for efficient muscle regeneration in mouse models of injury and muscular dystrophy
    Miriam Bobadilla
    Cell Therapy Area, Division of Cancer, Center for Applied Medical Research CIMA, University of Navarra, Pamplona, Spain
    Stem Cells 32:447-61. 2014
    ..Furthermore, our data suggest that MMP-10-mediated muscle repair is associated with VEGF/Akt signaling. Thus, our findings indicate that MMP-10 is critical for skeletal muscle maintenance and regeneration during injury and disease...
  54. ncbi request reprint Maintained effectiveness of an electronic alert system to prevent venous thromboembolism among hospitalized patients
    Ramon Lecumberri
    Hematology Service, University Clinic of Navarra, Av Pio XII 36, Pamplona, Spain
    Thromb Haemost 100:699-704. 2008
    ..For the first time, an intervention aimed to improve VTE prophylaxis shows maintained effectiveness over time...
  55. doi request reprint In vivo assessment of a new method of pulsatile perfusion based on a centrifugal pump
    Jesus Herreros
    Cardiovascular Surgery Department, Clinica Universitaria, University of Navarra, Pamplona, Spain
    Artif Organs 34:140-6. 2010
    ..The results suggest that the hemodynamic performance of the new pump is similar to a conventional centrifugal pump and could therefore be appropriate for use in extracorporeal circulation...
  56. ncbi request reprint Independent association of matrix metalloproteinase-10, cardiovascular risk factors and subclinical atherosclerosis
    J Orbe
    Laboratory of Atherosclerosis, Division of Cardiovascular Sciences, Center for Applied Medical Research, Pamplona, Spain
    J Thromb Haemost 5:91-7. 2007
    ..Whether MMP-10 is associated with the severity of atherosclerosis remains to be determined. This study examines the relationship of systemic MMP-10 levels with atherosclerotic risk factors and subclinical atherosclerosis...
  57. doi request reprint Tissue-specific PAI-1 gene expression and glycosylation pattern in insulin-resistant old rats
    R Serrano
    Atherothrombosis Research, Centre for Applied Medical Research, University of Navarra, Pamplona, Spain
    Am J Physiol Regul Integr Comp Physiol 297:R1563-9. 2009
    ..Additionally, the high degree of PAI-1 glycosylation and activity, together with the significant increase in visceral fat in old rats, may well contribute to an increased cardiovascular risk associated with insulin-resistant states...