Research Topics
| Julio J OchoaSummaryAffiliation: University of Granada Country: Spain Publications
| Collaborators
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Detail Information
Publications
Coenzyme Q10 protects from aging-related oxidative stress and improves mitochondrial function in heart of rats fed a polyunsaturated fatty acid (PUFA)-rich dietJulio J Ochoa
Institute of Nutrition and Food Technology, Department of Physiology, University of Granada, Spain
J Gerontol A Biol Sci Med Sci 60:970-5. 2005....- Effect of lifelong coenzyme Q10 supplementation on age-related oxidative stress and mitochondrial function in liver and skeletal muscle of rats fed on a polyunsaturated fatty acid (PUFA)-rich dietJulio J Ochoa
Department of Physiology, University of Granada, Granada, Spain
J Gerontol A Biol Sci Med Sci 62:1211-8. 2007..These findings provide mechanisms to explain the effect of CoQ(10) in extending the life span of animals fed a PUFA-rich diet... - Conjugated linoleic acids (CLAs) decrease prostate cancer cell proliferation: different molecular mechanisms for cis-9, trans-11 and trans-10, cis-12 isomersJulio J Ochoa
Institute of Nutrition and Food Technology, Department of Physiology, University of Granada, C Ramon y Cajal 4, 18071, Granada, Spain
Carcinogenesis 25:1185-91. 2004..Trans-10, cis-12 seems to work preferentially through modulation of apoptosis and cell cycle control, while c9,t11 CLA isomer affects arachidonic acid metabolism... - Aging-related oxidative stress depends on dietary lipid source in rat postmitotic tissuesJulio J Ochoa
Department of Physiology, Institute of Nutrition and Food Technology, University of Granada, Granada, Spain
J Bioenerg Biomembr 35:267-75. 2003..This study confirms that postmitotic tissues are more prone to oxidative stress during aging and proposes a hypothesis to explain this phenomenon... 
Melatonin supplementation ameliorates oxidative stress and inflammatory signaling induced by strenuous exercise in adult human malesJulio J Ochoa
Department of Physiology, University of Granada, Granada, Spain
J Pineal Res 51:373-80. 2011..In summary, melatonin supplementation before strenuous exercise reduced muscle damage through modulation of oxidative stress and inflammation signaling associated with this physical challenge...- Oxidative stress in patients undergoing cardiac surgery: comparative study of revascularization and valve replacement proceduresJulio J Ochoa
Institute of Nutrition and Food Technology INYTA, Department of Physiology, University of Granada, Granada, Spain
J Surg Res 111:248-54. 2003.... - Oxidative stress in erythrocytes from premature and full-term infants during their first 72 h of lifeJulio J Ochoa
Institute of Nutrition and Food Technology INYTA, Granada, Spain
Free Radic Res 37:317-22. 2003.... - Oxidative stress is evident in erythrocytes as well as plasma in patients undergoing heart surgery involving cardiopulmonary bypassJulio J Ochoa
Departmet of Physiology, Institute of Nutrition and Food Technology INYTA, University of Granada, C Ramon y Cajal, 4, 18071 Granda, Spain
Free Radic Res 37:11-7. 2003..The aim of this study was to analyse the level and progression of oxidative stress, in both plasma and erythrocytes, during heart surgery involving cardiopulmonary bypass... - Fluidity and oxidative stress in erythrocytes from very low birth weight infants during their first 7 days of lifeJulio J Ochoa
Institute of Nutrition and Food Technology, Department of Physiology, University of Granada, Granada, Spain
Free Radic Res 41:1035-40. 2007..To study the evolution of lipid peroxidation, enzymatic antioxidants response, lipid profile and membrane fluidity in erythrocytes from very low birth weight (VLBW) infants during their first 7 days of extra-uterine life... - Ageing-related tissue-specific alterations in mitochondrial composition and function are modulated by dietary fat type in the ratJose L Quiles
Department of Physiology, Institute of Nutrition and Food Technology, University of Granada, C Ramon y Cajal 4, 18071 Granada, Spain
J Bioenerg Biomembr 34:517-24. 2002..Since high levels of cytochrome b have been related to increased age, it could be hypothesized that olive oil could lead to less aged mitochondria... - Coenzyme Q(10) supplementation ameliorates inflammatory signaling and oxidative stress associated with strenuous exerciseJavier Díaz-Castro
Department of Physiology, University of Granada, Granada, Spain
Eur J Nutr 51:791-9. 2012..Exhausting exercise induces muscle damage associated with high production of free radicals and pro-inflammatory mediators... - Coenzyme Q addition to an n-6 PUFA-rich diet resembles benefits on age-related mitochondrial DNA deletion and oxidative stress of a MUFA-rich diet in rat heartJose L Quiles
Institute of Nutrition and Food Technology José Mataix Verdú, Department of Physiology, University of Granada, Granada, Spain
Mech Ageing Dev 131:38-47. 2010..Moreover, under our experimental conditions, lipid-derived oxidative damage appears to be more important than the pure protein-derived oxidative damage during aging... - Phlebodium decumanum is a natural supplement that ameliorates the oxidative stress and inflammatory signalling induced by strenuous exercise in adult humansJavier Díaz-Castro
Department of Physiology, Faculty of Pharmacy, University of Granada, Granada, Spain
Eur J Appl Physiol 112:3119-28. 2012.... - Life-long supplementation with a low dosage of coenzyme Q10 in the rat: effects on antioxidant status and DNA damageJose L Quiles
Institute of Nutrition and Food Technology, Department of Physiology, University of Granada, Spain
Biofactors 25:73-86. 2005..In addition, CoQ(10) supplementation attenuates the age-related fall in total antioxidant capacity of plasma and the increase in DNA damage in peripheral blood lymphocytes... - Age-related changes in brain mitochondrial DNA deletion and oxidative stress are differentially modulated by dietary fat type and coenzyme Q₁₀Julio J Ochoa
Institute of Nutrition and Food Technology José Mataix Verdú, University of Granada, 18071 Granada, Spain
Free Radic Biol Med 50:1053-64. 2011.... - Dietary fat type (virgin olive vs. sunflower oils) affects age-related changes in DNA double-strand-breaks, antioxidant capacity and blood lipids in ratsJose L Quiles
Department of Physiology, Institute of Nutrition and Food Technology, University of Granada, C Ramón y Cajal 4 Edificio Fray Luis, Granada 18071, Spain
Exp Gerontol 39:1189-98. 2004..In the present study best results were found after intake of virgin olive oil, which suggest the possible use of that edible oil to provide a healthier aging... - Age-related mitochondrial DNA deletion in rat liver depends on dietary fat unsaturationJose L Quiles
Department of Physiology, Institute of Nutrition and Food Technology, University of Granada, Spain
J Gerontol A Biol Sci Med Sci 61:107-14. 2006..Results suggest that the age-related increase of the relative amount of deleted mtDNA depends on fat unsaturation. Moreover, the studied mtDNA deletion was correlated with mitochondrial oxidative stress and ultrastructural alterations... - Coenzyme Q supplementation protects from age-related DNA double-strand breaks and increases lifespan in rats fed on a PUFA-rich dietJose L Quiles
Department of Physiology, Institute of Nutrition and Food Technology, University of Granada, Ramón y Cajal 4 Edif Fray Luis de Granada, Granada 18071, Spain
Exp Gerontol 39:189-94. 2004..e. 6 months) than non-supplemented animals. These results suggest that a long-term supplementation with a small dosage of coenzyme Q(10) might represent a good anti-aging therapy in rats fed on a PUFA-based diet... - Coenzyme Q concentration and total antioxidant capacity of human milk at different stages of lactation in mothers of preterm and full-term infantsJose L Quiles
Institute of Nutrition and Food Technology, University of Granada, Department of Physiology, Granada, Spain
Free Radic Res 40:199-206. 2006..CoQ10 in breast milk decreases through lactation in mothers delivering full-term infants. Also, CoQ10, alpha- and gamma-tocopherol concentration in human milk directly correlates with the antioxidant capacity of the milk... - Oxidative stress status in liver mitochondria and lymphocyte DNA damage of atherosclerotic rabbits supplemented with water soluble coenzyme Q10M Carmen Ramirez-Tortosa
Department of Biochemistry and Molecular Biology II, Institute of Nutrition and Food Technology INYTA, University of Granada, Granada, Spain
Biofactors 32:263-73. 2008..The findings suggest that antioxidant therapy with coenzyme Q10 may be used in the treatment of liver pathologies associated to the intake of high-fat, atherogenic, diets... - Dietary fat (virgin olive oil or sunflower oil) and physical training interactions on blood lipids in the ratJose L Quiles
Institute of Nutrition and Food Technology, Department of Physiology, University of Granada, Granada, Spain
Nutrition 19:363-8. 2003..We investigated whether the intake of virgin olive oil or sunflower oil and performance of physical exercise (at different states) affect plasma levels of triacylglycerols, total cholesterol, and fatty acid profile in rats... - Dietary oils high in oleic acid but with different unsaponifiable fraction contents have different effects in fatty acid composition and peroxidation in rabbit LDLJulio J Ochoa
Institute of Nutrition and Food Technology, University of Granada, Granada, Spain
Nutrition 18:60-5. 2002..We investigated the influence of different edible oils high in oleic acid but with different unsaponifiable fractions on the fatty acid composition and lipid peroxidation in plasma and low-density lipoprotein (LDL) in rabbits... - Melatonin protects against lipid peroxidation and membrane rigidity in erythrocytes from patients undergoing cardiopulmonary bypass surgeryJulio J Ochoa
Department of Physiology, Institute of Nutrition and Food Technology, University of Granada, Granada, Spain
J Pineal Res 35:104-8. 2003..The results constitute a persuasive argument for the use of melatonin for preventive and therapeutic purposes during CPB... - Olive oil and modulation of cell signaling in disease preventionKlaus W J Wahle
School of Life Sciences, The Robert Gordon University, Aberdeen, AB25 1 HG, Scotland, United Kingdom
Lipids 39:1223-31. 2004..Adoption of a Mediterranean diet could confer health benefits in high-risk populations...