Research Topics
| Jose A ObesoSummaryAffiliation: University of Navarra Country: Spain Publications
| Collaborators
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Detail Information
Publications
Missing pieces in the Parkinson's disease puzzleJose A Obeso
Department of Neurology, Clínica Universitaria and Medical School of Navarra, Neuroscience Centre, Center for Applied Medical Research, Pamplona, Spain
Nat Med 16:653-61. 2010..Here we discuss a series of critical issues that we think researchers need to address to stand a better chance of solving the different challenges posed by this pathology...- Subthalamic activity during diphasic dyskinesias in Parkinson's diseaseManuel Alegre
Neurosciences Area, CIMA, University of Navarra, Pamplona, Spain
Mov Disord 27:1178-81. 2012..Diphasic dyskinesias are a subtype of levodopa-induced dyskinesias that appear typically at the onset and end of levodopa antiparkinsonian action. The pathophysiology of diphasic dyskinesias is not well understood... - The subthalamic nucleus is involved in successful inhibition in the stop-signal task: a local field potential study in Parkinson's diseaseManuel Alegre
Neurosciences Area, CIMA, University of Navarra, Pamplona, Spain
Exp Neurol 239:1-12. 2013..Our results provide direct support for the involvement of the subthalamic nucleus in response inhibition and suggest that this function may be mediated by a specific reduction in gamma oscillations in the cortico-subthalamic connection... - Progression of dopaminergic depletion in a model of MPTP-induced Parkinsonism in non-human primates. An (18)F-DOPA and (11)C-DTBZ PET studyJavier Blesa
Movement Disorders Group, Neurosciences Division, CIMA, and Department of Neurology and Neurosurgery, Clinica Universidad de Navarra, Pamplona, Spain
Neurobiol Dis 38:456-63. 2010..This approach could be useful to perform studies aiming to test the effect of early therapeutic intervention and putative neuroprotective treatments... - Involvement of the subthalamic nucleus in impulse control disorders associated with Parkinson's diseaseMaria C Rodriguez-Oroz
Department of Neurology, Clinica Universidad de Navarra, Medical School, 31008 Pamplona, Spain
Brain 134:36-49. 2011..Consequently, the subthalamic nucleus appears to be implicated in the motor and behavioural complications associated with dopaminergic drugs in Parkinson's disease, specifically engaging different anatomo-functional territories... - Functional organization of the basal ganglia: therapeutic implications for Parkinson's diseaseJose A Obeso
Department of Neurology and Neurosurgery, Clinica Universitaria and Medical School and Neuroscience Centre, CIMA, University of Navarra, Pamplona, Spain
Mov Disord 23:S548-59. 2008..This creates a scenario that substantially departs from the normal physiological state of the BG... 
The basal ganglia and disorders of movement: pathophysiological mechanismsJose A Obeso
Department of Neurology, Clinica Universitaria and Medical School, University of Navarra, Pamplona 31008, Spain
News Physiol Sci 17:51-5. 2002..Abnormal increment or reduction in the inhibitory output activity of basal ganglia give rise, respectively, to poverty and slowness of movement (i.e., Parkinson's disease) or dyskinesias...- Successful thalamic deep brain stimulation for orthostatic tremorJorge Guridi
Department of Neurology, Neurophysiology and Neurosurgery, Clinica Universitaria, Universidad de Navarra, Pamplona, Spain
Mov Disord 23:1808-11. 2008..This case suggests that Vim-DBS may be a useful therapeutic approach for patients highly disabled by OT... - L-dopa-induced dyskinesia and stereotactic surgery for Parkinson's diseaseJorge Guridi
Division of Neurosurgery, Neuroscience Department, University Clinic, University of Navarra, Pamplona, Spain
Neurosurgery 62:311-23; discussion 323-5. 2008..To assess the impact of different surgical targets and techniques, such as ablation and deep brain stimulation, to treat patients with L-dopa-induced dyskinesia (LID), a major therapeutic complication of Parkinson's disease... - A direct projection from the subthalamic nucleus to the ventral thalamus in monkeysAlberto J Rico
Area de Neurociencias, Centro de Investigación Médica Aplicada CIMA, Facultad de Medicina, Universidad de Navarra, Pamplona, Spain
Neurobiol Dis 39:381-92. 2010..In conclusion, our findings support the presence of a direct projection from the STN to the ventral thalamus that appears to be functionally modulated by dopaminergic activity... - Posterior parietooccipital hypometabolism may differentiate mild cognitive impairment from dementia in Parkinson's diseaseDavid Garcia-Garcia
Neurosciences Area, CIMA, Department of Neurology and Neurosurgery, Clinica Universidad de Navarra, University of Navarra, Pamplona, Spain
Eur J Nucl Med Mol Imaging 39:1767-77. 2012..We investigated differences in cerebral metabolism associated with these three cognitive states and the relationship between metabolism and cognitive dysfunction... - Statistical parametric maps of ¹⁸F-FDG PET and 3-D autoradiography in the rat brain: a cross-validation studyElena Prieto
Nuclear Medicine Department, Clinica Universidad de Navarra, Av Pio XII 36, 31008 Pamplona, Spain
Eur J Nucl Med Mol Imaging 38:2228-37. 2011..The gold standard for the validation of the PET results was the autoradiography of the same animals acquired under the same physiological conditions, reconstructed as a 3-D volume and analysed using SPM... - Chaperone-mediated autophagy markers in Parkinson disease brainsLydia Alvarez-Erviti
Centro Investigación Biomédica en Red Enfermedades Neurodegenerativas, University of Navarra, Pamplona, Spain
Arch Neurol 67:1464-72. 2010..To investigate chaperone-mediated autophagy in the pathogenesis of Parkinson disease (PD)... - Neuronal activity of the red nucleus in Parkinson's diseaseMaria C Rodriguez-Oroz
Department of Neurology and Neurosurgery, Clinica Universitaria and Medical School, Neuroscience Division, CIMA, University of Navarra, Pamplona, Spain
Mov Disord 23:908-11. 2008..This initial description of the physiological characteristics of the RN in humans will draw attention to the possibility of confusing the RN and STN during intraoperative recording... - Initial clinical manifestations of Parkinson's disease: features and pathophysiological mechanismsMaria C Rodriguez-Oroz
Department of Neurology, Clinica Universitaria and Medical School and Neuroscience, CIMA, University of Navarra, Pamplona, Spain
Lancet Neurol 8:1128-39. 2009.... - The basal ganglia in Parkinson's disease: current concepts and unexplained observationsJose A Obeso
Departments of Neurology, Neurophysiology and Neurosurgery, Clinica Universitaria and Medical School, Neuroscience Centre, Center for Applied Medical Research, University of Navarra, Pamplona, Spain
Ann Neurol 64:S30-46. 2008..The growing understanding of the complexity of the normal BG and the changes induced by DA depletion should guide the development of more efficacious therapies for Parkinson's disease... - Beta activity in the subthalamic nucleus during sleep in patients with Parkinson's diseaseElena Urrestarazu
Department of Neurology and Neurosurgery, Clinica Universitaria and Medical School, and Neurosciences Division, CIMA University of Navarra, Pamplona, Spain
Mov Disord 24:254-60. 2009..These findings indicate that STN activity is modulated and modified during different sleep stages. The increased beta activity during REM sleep is a new but unexpected finding, which requires further analysis... - Thalamic innervation of striatal and subthalamic neurons projecting to the rat entopeduncular nucleusJose L Lanciego
Department of Anatomy, Clinica Universitaria and Medical School, Foundation for Applied Medical Research F I M A, University of Navarra, c Irunlarrea no 1, 31008 Pamplona, Spain
Eur J Neurosci 19:1267-77. 2004..These circuits enabled the caudal intralaminar nuclei to modulate basal ganglia output... - LRRK2 haplotype-sharing analysis in Parkinson's disease reveals a novel p.S1761R mutationOswaldo Lorenzo-Betancor
Neurogenetics Laboratory, Division of Neurosciences, Center for Applied Medical Research, University of Navarra, Pamplona, Spain
Mov Disord 27:146-51. 2012..Our aim was to identify novel LRRK2 mutations in late-onset Parkinson's disease families... - The pathophysiological basis of sensory disturbances in Parkinson's diseaseCarlos Juri
Departments of Neurology, Neurophysiology and Neurosurgery, Clinica Universitaria and Medical School, Neuroscience Centre, Center for Applied Medical Research, University of Navarra, Pamplona, Spain
J Neurol Sci 289:60-5. 2010..Thus, more clinical and basic studies are warranted to clarify pain mechanisms in PD, with the aim of achieving better treatments... - The duration of the motor response to apomorphine boluses is conditioned by the length of a prior infusion in Parkinson's diseaseJulia Vaamonde
Department of Neurology, Hospital General, Ciudad Real, Spain
Mov Disord 24:762-5. 2009..01) with the on induced by the MED-2 of apomorphine. Our findings indicate that a continuous dopaminergic stimulus may induce pharmacodynamic changes associated with tolerance in PD patients... - Striatal dopamine function in a family with multiple SCA-3 phenotypesEsther Cubo
Department of Neurology, Hospital General Yague, Avda Cid 96, 09005, Burgos, Spain
J Neurol 258:308-10. 2011..SCA-3 can present with a levodopa responsive parkinsonism phenotype, and an abnormal DAT scan showing predominant impairment of presynaptic dopamine function... - Homocysteine and cognitive impairment in Parkinson's disease: a biochemical, neuroimaging, and genetic studyMaria C Rodriguez-Oroz
Department of Neurology, University Clinic and Medical School of Navarra, Pamplona, Spain
Mov Disord 24:1437-44. 2009..We found no evidence for a direct relationship between Hcy plasma levels and cognitive impairment and dementia in PD. No indirect effect through cerebrovascular disease or genetic background was found either... - LINGO1 gene analysis in Parkinson's disease phenotypesOswaldo Lorenzo-Betancor
Division of Neurosciences, Neurogenetics Laboratory, Center for Applied Medical Research, University of Navarra, Pamplona, Spain
Mov Disord 26:722-7. 2011..A genome-wide association study has shown that LINGO1 gene variants are associated with increased risk of ET. We hypothesized that LINGO1 variants could increase susceptibility to PD... - Lesion of the centromedian thalamic nucleus in MPTP-treated monkeysJose L Lanciego
Neurosciences Division, CIMA, Pamplona, University of Navarra, Spain
Mov Disord 23:708-15. 2008..The role of the caudal intralaminar nuclei in the pathophysiology of movement disorders of basal ganglia origin remains to be clarified... 
Functional neuroanatomy of the basal gangliaJose L Lanciego
Department of Neuroscience, Center for Applied Medical Research CIMA and CIBERNED, University of Navarra Medical College, Pamplona, Spain
Cold Spring Harb Perspect Med 2:a009621. 2012....- The globus pallidus pars externa and Parkinson's disease. Ready for prime time?Jose A Obeso
Department of Neurology and Neurosurgery, Clinica Universitaria and Medical School, and Neuroscience Centre, CIMA, University of Navarra, Pamplona, Spain
Exp Neurol 202:1-7. 2006 - Past, present, and future of the pathophysiological model of the Basal GangliaJose A Obeso
Neurosciences Division, Center for Applied Medical Research, University of Navarra Pamplona, Spain
Front Neuroanat 5:39. 2011..Detailed accounts and state-of-the-art developments concerning research on the BG are provided in the articles that make up this Special Issue...