Jose A Obeso

Summary

Affiliation: University of Navarra
Country: Spain

Publications

  1. doi request reprint Missing pieces in the Parkinson's disease puzzle
    Jose A Obeso
    Department of Neurology, Clínica Universitaria and Medical School of Navarra, Neuroscience Centre, Center for Applied Medical Research, Pamplona, Spain
    Nat Med 16:653-61. 2010
  2. doi request reprint Subthalamic activity during diphasic dyskinesias in Parkinson's disease
    Manuel Alegre
    Neurosciences Area, CIMA, University of Navarra, Pamplona, Spain
    Mov Disord 27:1178-81. 2012
  3. doi request reprint The subthalamic nucleus is involved in successful inhibition in the stop-signal task: a local field potential study in Parkinson's disease
    Manuel Alegre
    Neurosciences Area, CIMA, University of Navarra, Pamplona, Spain
    Exp Neurol 239:1-12. 2013
  4. doi request reprint Progression of dopaminergic depletion in a model of MPTP-induced Parkinsonism in non-human primates. An (18)F-DOPA and (11)C-DTBZ PET study
    Javier Blesa
    Movement Disorders Group, Neurosciences Division, CIMA, and Department of Neurology and Neurosurgery, Clinica Universidad de Navarra, Pamplona, Spain
    Neurobiol Dis 38:456-63. 2010
  5. doi request reprint Involvement of the subthalamic nucleus in impulse control disorders associated with Parkinson's disease
    Maria C Rodriguez-Oroz
    Department of Neurology, Clinica Universidad de Navarra, Medical School, 31008 Pamplona, Spain
    Brain 134:36-49. 2011
  6. doi request reprint Effect of deep brain stimulation of the subthalamic nucleus on non-motor fluctuations in Parkinson's disease: two-years' follow-up
    Sara Ortega-Cubero
    Neurology and Neurosurgery, Clinica Universidad de Navarra, Pamplona, Spain
    Parkinsonism Relat Disord 19:543-7. 2013
  7. ncbi request reprint Thalamic innervation of the direct and indirect basal ganglia pathways in the rat: Ipsi- and contralateral projections
    Maria Castle
    Department of Anatomy, Division of Neurosciences, Clinica Universitaria and Medical School, Center for Applied Medical Research, University of Navarra, 31008 Navarra, Spain
    J Comp Neurol 483:143-53. 2005
  8. doi request reprint l-dopa-induced dyskinesias in unilateral 6-hydroxydopamine-lesioned rats are not modified by excitotoxic lesion of the entopeduncular nucleus and substantia nigra pars reticulata
    Belen Gago
    Department of Neurology and Neuroscience Area, Clinica Universitaria and Medical School, University of Navarra and CIMA, Pamplona, Spain
    Synapse 67:407-14. 2013
  9. doi request reprint Functional organization of the basal ganglia: therapeutic implications for Parkinson's disease
    Jose A Obeso
    Department of Neurology and Neurosurgery, Clinica Universitaria and Medical School and Neuroscience Centre, CIMA, University of Navarra, Pamplona, Spain
    Mov Disord 23:S548-59. 2008
  10. doi request reprint Posterior parietooccipital hypometabolism may differentiate mild cognitive impairment from dementia in Parkinson's disease
    David Garcia-Garcia
    Neurosciences Area, CIMA, Department of Neurology and Neurosurgery, Clinica Universidad de Navarra, University of Navarra, Pamplona, Spain
    Eur J Nucl Med Mol Imaging 39:1767-77. 2012

Collaborators

Detail Information

Publications32

  1. doi request reprint Missing pieces in the Parkinson's disease puzzle
    Jose A Obeso
    Department of Neurology, Clínica Universitaria and Medical School of Navarra, Neuroscience Centre, Center for Applied Medical Research, Pamplona, Spain
    Nat Med 16:653-61. 2010
    ..Here we discuss a series of critical issues that we think researchers need to address to stand a better chance of solving the different challenges posed by this pathology...
  2. doi request reprint Subthalamic activity during diphasic dyskinesias in Parkinson's disease
    Manuel Alegre
    Neurosciences Area, CIMA, University of Navarra, Pamplona, Spain
    Mov Disord 27:1178-81. 2012
    ..Diphasic dyskinesias are a subtype of levodopa-induced dyskinesias that appear typically at the onset and end of levodopa antiparkinsonian action. The pathophysiology of diphasic dyskinesias is not well understood...
  3. doi request reprint The subthalamic nucleus is involved in successful inhibition in the stop-signal task: a local field potential study in Parkinson's disease
    Manuel Alegre
    Neurosciences Area, CIMA, University of Navarra, Pamplona, Spain
    Exp Neurol 239:1-12. 2013
    ..Our results provide direct support for the involvement of the subthalamic nucleus in response inhibition and suggest that this function may be mediated by a specific reduction in gamma oscillations in the cortico-subthalamic connection...
  4. doi request reprint Progression of dopaminergic depletion in a model of MPTP-induced Parkinsonism in non-human primates. An (18)F-DOPA and (11)C-DTBZ PET study
    Javier Blesa
    Movement Disorders Group, Neurosciences Division, CIMA, and Department of Neurology and Neurosurgery, Clinica Universidad de Navarra, Pamplona, Spain
    Neurobiol Dis 38:456-63. 2010
    ..This approach could be useful to perform studies aiming to test the effect of early therapeutic intervention and putative neuroprotective treatments...
  5. doi request reprint Involvement of the subthalamic nucleus in impulse control disorders associated with Parkinson's disease
    Maria C Rodriguez-Oroz
    Department of Neurology, Clinica Universidad de Navarra, Medical School, 31008 Pamplona, Spain
    Brain 134:36-49. 2011
    ..Consequently, the subthalamic nucleus appears to be implicated in the motor and behavioural complications associated with dopaminergic drugs in Parkinson's disease, specifically engaging different anatomo-functional territories...
  6. doi request reprint Effect of deep brain stimulation of the subthalamic nucleus on non-motor fluctuations in Parkinson's disease: two-years' follow-up
    Sara Ortega-Cubero
    Neurology and Neurosurgery, Clinica Universidad de Navarra, Pamplona, Spain
    Parkinsonism Relat Disord 19:543-7. 2013
    ..In this study we assess the efficacy of STN-DBS on NMF two years after surgery...
  7. ncbi request reprint Thalamic innervation of the direct and indirect basal ganglia pathways in the rat: Ipsi- and contralateral projections
    Maria Castle
    Department of Anatomy, Division of Neurosciences, Clinica Universitaria and Medical School, Center for Applied Medical Research, University of Navarra, 31008 Navarra, Spain
    J Comp Neurol 483:143-53. 2005
    ..These ipsi- and contralateral projections enable the caudal intralaminar nuclei to modulate the activity of both the direct and the indirect pathway...
  8. doi request reprint l-dopa-induced dyskinesias in unilateral 6-hydroxydopamine-lesioned rats are not modified by excitotoxic lesion of the entopeduncular nucleus and substantia nigra pars reticulata
    Belen Gago
    Department of Neurology and Neuroscience Area, Clinica Universitaria and Medical School, University of Navarra and CIMA, Pamplona, Spain
    Synapse 67:407-14. 2013
    ....
  9. doi request reprint Functional organization of the basal ganglia: therapeutic implications for Parkinson's disease
    Jose A Obeso
    Department of Neurology and Neurosurgery, Clinica Universitaria and Medical School and Neuroscience Centre, CIMA, University of Navarra, Pamplona, Spain
    Mov Disord 23:S548-59. 2008
    ..This creates a scenario that substantially departs from the normal physiological state of the BG...
  10. doi request reprint Posterior parietooccipital hypometabolism may differentiate mild cognitive impairment from dementia in Parkinson's disease
    David Garcia-Garcia
    Neurosciences Area, CIMA, Department of Neurology and Neurosurgery, Clinica Universidad de Navarra, University of Navarra, Pamplona, Spain
    Eur J Nucl Med Mol Imaging 39:1767-77. 2012
    ..We investigated differences in cerebral metabolism associated with these three cognitive states and the relationship between metabolism and cognitive dysfunction...
  11. pmc Functional neuroanatomy of the basal ganglia
    Jose L Lanciego
    Department of Neuroscience, Center for Applied Medical Research CIMA and CIBERNED, University of Navarra Medical College, Pamplona, Spain
    Cold Spring Harb Perspect Med 2:a009621. 2012
    ....
  12. ncbi request reprint The basal ganglia and disorders of movement: pathophysiological mechanisms
    Jose A Obeso
    Department of Neurology, Clinica Universitaria and Medical School, University of Navarra, Pamplona 31008, Spain
    News Physiol Sci 17:51-5. 2002
    ..Abnormal increment or reduction in the inhibitory output activity of basal ganglia give rise, respectively, to poverty and slowness of movement (i.e., Parkinson's disease) or dyskinesias...
  13. doi request reprint A direct projection from the subthalamic nucleus to the ventral thalamus in monkeys
    Alberto J Rico
    Area de Neurociencias, Centro de Investigación Médica Aplicada CIMA, Facultad de Medicina, Universidad de Navarra, Pamplona, Spain
    Neurobiol Dis 39:381-92. 2010
    ..In conclusion, our findings support the presence of a direct projection from the STN to the ventral thalamus that appears to be functionally modulated by dopaminergic activity...
  14. doi request reprint L-dopa-induced dyskinesia and stereotactic surgery for Parkinson's disease
    Jorge Guridi
    Division of Neurosurgery, Neuroscience Department, University Clinic, University of Navarra, Pamplona, Spain
    Neurosurgery 62:311-23; discussion 323-5. 2008
    ..To assess the impact of different surgical targets and techniques, such as ablation and deep brain stimulation, to treat patients with L-dopa-induced dyskinesia (LID), a major therapeutic complication of Parkinson's disease...
  15. doi request reprint Successful thalamic deep brain stimulation for orthostatic tremor
    Jorge Guridi
    Department of Neurology, Neurophysiology and Neurosurgery, Clinica Universitaria, Universidad de Navarra, Pamplona, Spain
    Mov Disord 23:1808-11. 2008
    ..This case suggests that Vim-DBS may be a useful therapeutic approach for patients highly disabled by OT...
  16. doi request reprint Statistical parametric maps of ¹⁸F-FDG PET and 3-D autoradiography in the rat brain: a cross-validation study
    Elena Prieto
    Nuclear Medicine Department, Clinica Universidad de Navarra, Av Pio XII 36, 31008 Pamplona, Spain
    Eur J Nucl Med Mol Imaging 38:2228-37. 2011
    ..The gold standard for the validation of the PET results was the autoradiography of the same animals acquired under the same physiological conditions, reconstructed as a 3-D volume and analysed using SPM...
  17. doi request reprint Beta activity in the subthalamic nucleus during sleep in patients with Parkinson's disease
    Elena Urrestarazu
    Department of Neurology and Neurosurgery, Clinica Universitaria and Medical School, and Neurosciences Division, CIMA University of Navarra, Pamplona, Spain
    Mov Disord 24:254-60. 2009
    ..These findings indicate that STN activity is modulated and modified during different sleep stages. The increased beta activity during REM sleep is a new but unexpected finding, which requires further analysis...
  18. doi request reprint Chaperone-mediated autophagy markers in Parkinson disease brains
    Lydia Alvarez-Erviti
    Centro Investigación Biomédica en Red Enfermedades Neurodegenerativas, University of Navarra, Pamplona, Spain
    Arch Neurol 67:1464-72. 2010
    ..To investigate chaperone-mediated autophagy in the pathogenesis of Parkinson disease (PD)...
  19. doi request reprint The basal ganglia in Parkinson's disease: current concepts and unexplained observations
    Jose A Obeso
    Departments of Neurology, Neurophysiology and Neurosurgery, Clinica Universitaria and Medical School, Neuroscience Centre, Center for Applied Medical Research, University of Navarra, Pamplona, Spain
    Ann Neurol 64:S30-46. 2008
    ..The growing understanding of the complexity of the normal BG and the changes induced by DA depletion should guide the development of more efficacious therapies for Parkinson's disease...
  20. doi request reprint Neuronal activity of the red nucleus in Parkinson's disease
    Maria C Rodriguez-Oroz
    Department of Neurology and Neurosurgery, Clinica Universitaria and Medical School, Neuroscience Division, CIMA, University of Navarra, Pamplona, Spain
    Mov Disord 23:908-11. 2008
    ..This initial description of the physiological characteristics of the RN in humans will draw attention to the possibility of confusing the RN and STN during intraoperative recording...
  21. doi request reprint Initial clinical manifestations of Parkinson's disease: features and pathophysiological mechanisms
    Maria C Rodriguez-Oroz
    Department of Neurology, Clinica Universitaria and Medical School and Neuroscience, CIMA, University of Navarra, Pamplona, Spain
    Lancet Neurol 8:1128-39. 2009
    ....
  22. ncbi request reprint Thalamic innervation of striatal and subthalamic neurons projecting to the rat entopeduncular nucleus
    Jose L Lanciego
    Department of Anatomy, Clinica Universitaria and Medical School, Foundation for Applied Medical Research F I M A, University of Navarra, c Irunlarrea no 1, 31008 Pamplona, Spain
    Eur J Neurosci 19:1267-77. 2004
    ..These circuits enabled the caudal intralaminar nuclei to modulate basal ganglia output...
  23. doi request reprint LRRK2 haplotype-sharing analysis in Parkinson's disease reveals a novel p.S1761R mutation
    Oswaldo Lorenzo-Betancor
    Neurogenetics Laboratory, Division of Neurosciences, Center for Applied Medical Research, University of Navarra, Pamplona, Spain
    Mov Disord 27:146-51. 2012
    ..Our aim was to identify novel LRRK2 mutations in late-onset Parkinson's disease families...
  24. doi request reprint The pathophysiological basis of sensory disturbances in Parkinson's disease
    Carlos Juri
    Departments of Neurology, Neurophysiology and Neurosurgery, Clinica Universitaria and Medical School, Neuroscience Centre, Center for Applied Medical Research, University of Navarra, Pamplona, Spain
    J Neurol Sci 289:60-5. 2010
    ..Thus, more clinical and basic studies are warranted to clarify pain mechanisms in PD, with the aim of achieving better treatments...
  25. doi request reprint LINGO1 gene analysis in Parkinson's disease phenotypes
    Oswaldo Lorenzo-Betancor
    Division of Neurosciences, Neurogenetics Laboratory, Center for Applied Medical Research, University of Navarra, Pamplona, Spain
    Mov Disord 26:722-7. 2011
    ..A genome-wide association study has shown that LINGO1 gene variants are associated with increased risk of ET. We hypothesized that LINGO1 variants could increase susceptibility to PD...
  26. doi request reprint Striatal dopamine function in a family with multiple SCA-3 phenotypes
    Esther Cubo
    Department of Neurology, Hospital General Yague, Avda Cid 96, 09005, Burgos, Spain
    J Neurol 258:308-10. 2011
    ..SCA-3 can present with a levodopa responsive parkinsonism phenotype, and an abnormal DAT scan showing predominant impairment of presynaptic dopamine function...
  27. doi request reprint The duration of the motor response to apomorphine boluses is conditioned by the length of a prior infusion in Parkinson's disease
    Julia Vaamonde
    Department of Neurology, Hospital General, Ciudad Real, Spain
    Mov Disord 24:762-5. 2009
    ..01) with the on induced by the MED-2 of apomorphine. Our findings indicate that a continuous dopaminergic stimulus may induce pharmacodynamic changes associated with tolerance in PD patients...
  28. doi request reprint Homocysteine and cognitive impairment in Parkinson's disease: a biochemical, neuroimaging, and genetic study
    Maria C Rodriguez-Oroz
    Department of Neurology, University Clinic and Medical School of Navarra, Pamplona, Spain
    Mov Disord 24:1437-44. 2009
    ..We found no evidence for a direct relationship between Hcy plasma levels and cognitive impairment and dementia in PD. No indirect effect through cerebrovascular disease or genetic background was found either...
  29. doi request reprint Lesion of the centromedian thalamic nucleus in MPTP-treated monkeys
    Jose L Lanciego
    Neurosciences Division, CIMA, Pamplona, University of Navarra, Spain
    Mov Disord 23:708-15. 2008
    ..The role of the caudal intralaminar nuclei in the pathophysiology of movement disorders of basal ganglia origin remains to be clarified...
  30. doi request reprint Ascorbate prevents cell death from prolonged exposure to glutamate in an in vitro model of human dopaminergic neurons
    Santiago Ballaz
    Laboratory of Movement Disorders, Department of Neuroscience, Centre for Applied Medicine Research CIMA, University of Navarra, Pamplona, Spain Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas, CIBERNED, Madrid, Spain
    J Neurosci Res 91:1609-17. 2013
    ..Occurrence of a glutamate-ascorbate link in dopaminergic neurons may explain previous contradictions regarding their putative role in PD...
  31. ncbi request reprint The globus pallidus pars externa and Parkinson's disease. Ready for prime time?
    Jose A Obeso
    Department of Neurology and Neurosurgery, Clinica Universitaria and Medical School, and Neuroscience Centre, CIMA, University of Navarra, Pamplona, Spain
    Exp Neurol 202:1-7. 2006
  32. pmc Past, present, and future of the pathophysiological model of the Basal Ganglia
    Jose A Obeso
    Neurosciences Division, Center for Applied Medical Research, University of Navarra Pamplona, Spain
    Front Neuroanat 5:39. 2011
    ..Detailed accounts and state-of-the-art developments concerning research on the BG are provided in the articles that make up this Special Issue...