J Nacher

Summary

Affiliation: University of Valencia
Country: Spain

Publications

  1. doi request reprint Structural plasticity of interneurons in the adult brain: role of PSA-NCAM and implications for psychiatric disorders
    Juan Nacher
    Neurobiology Unit and Program in Basic and Applied Neurosciences, Cell Biology Department, Universitat de Valencia, Dr Moliner, 50, 46100 Burjassot, Spain
    Neurochem Res 38:1122-33. 2013
  2. pmc Chronic fluoxetine treatment in middle-aged rats induces changes in the expression of plasticity-related molecules and in neurogenesis
    Ramón Guirado
    Neurobiology Unit and Program in Basic and Applied Neurosciences, Cell Biology Dpt, Universitat de Valencia, Spain
    BMC Neurosci 13:5. 2012
  3. ncbi request reprint Chronic restraint stress and chronic corticosterone treatment modulate differentially the expression of molecules related to structural plasticity in the adult rat piriform cortex
    J Nacher
    Laboratory of Neuroendocrinology, Rockefeller University, New York, NY 10021, USA
    Neuroscience 126:503-9. 2004
  4. ncbi request reprint Expression of the transcription factor Pax 6 in the adult rat dentate gyrus
    Juan Nacher
    Neurobiology, Cell Biology Department, Universitat de Valencia, Burjassot, Spain
    J Neurosci Res 81:753-61. 2005
  5. ncbi request reprint NMDA receptor antagonist treatment increases the production of new neurons in the aged rat hippocampus
    Juan Nacher
    Laboratory of Neuroendocrinology, The Rockefeller University, 1230 York Avenue, New York, NY 10021, USA
    Neurobiol Aging 24:273-84. 2003
  6. ncbi request reprint CRMP-4 expression in the adult cerebral cortex and other telencephalic areas of the lizard Podarcis hispanica
    Juan Nacher
    Neurobiologia, Biologia Celular, Facultad de Ciencias Biologicas, Universidad de Valencia, 46100 Burjassot, Valencia, Spain
    Brain Res Dev Brain Res 139:285-94. 2002
  7. ncbi request reprint Chronic non-invasive glucocorticoid administration decreases polysialylated neural cell adhesion molecule expression in the adult rat dentate gyrus
    Juan Nacher
    Neurobiology, Cell Biology Department, Universitat de Valencia, Dr Moliner, 50, Burjassot 46100, Spain
    Neurosci Lett 370:40-4. 2004
  8. ncbi request reprint Distribution of PSA-NCAM expression in the amygdala of the adult rat
    J Nacher
    Laboratory of Neuroendocrinology, Rockefeller University, New York, NY 10021, USA
    Neuroscience 113:479-84. 2002
  9. doi request reprint Divergent impact of the polysialyltransferases ST8SiaII and ST8SiaIV on polysialic acid expression in immature neurons and interneurons of the adult cerebral cortex
    J Nacher
    Cell Biology Department, Universitat de Valencia, Burjassot, Spain
    Neuroscience 167:825-37. 2010
  10. ncbi request reprint Non-granule PSA-NCAM immunoreactive neurons in the rat hippocampus
    Juan Nacher
    Harold and Margaret Milliken Hatch Laboratory of Neuroendocrinology, Rockefeller University, York Avenue 1230, New York, NY 10021, USA
    Brain Res 930:1-11. 2002

Collaborators

Detail Information

Publications34

  1. doi request reprint Structural plasticity of interneurons in the adult brain: role of PSA-NCAM and implications for psychiatric disorders
    Juan Nacher
    Neurobiology Unit and Program in Basic and Applied Neurosciences, Cell Biology Department, Universitat de Valencia, Dr Moliner, 50, 46100 Burjassot, Spain
    Neurochem Res 38:1122-33. 2013
    ..Finally, we review recent findings on the possible implication of PSA-NCAM on the remodeling of inhibitory neurons in certain psychiatric disorders and their treatments...
  2. pmc Chronic fluoxetine treatment in middle-aged rats induces changes in the expression of plasticity-related molecules and in neurogenesis
    Ramón Guirado
    Neurobiology Unit and Program in Basic and Applied Neurosciences, Cell Biology Dpt, Universitat de Valencia, Spain
    BMC Neurosci 13:5. 2012
    ..PSA-NCAM is expressed in immature neurons and in a subpopulation of mature interneurons and its expression is modulated by antidepressants in the telencephalon of young-adult rodents...
  3. ncbi request reprint Chronic restraint stress and chronic corticosterone treatment modulate differentially the expression of molecules related to structural plasticity in the adult rat piriform cortex
    J Nacher
    Laboratory of Neuroendocrinology, Rockefeller University, New York, NY 10021, USA
    Neuroscience 126:503-9. 2004
    ..This is a potential mechanism by which stress and corticosterone modulate functions of this limbic region, such as its participation in olfactory memory...
  4. ncbi request reprint Expression of the transcription factor Pax 6 in the adult rat dentate gyrus
    Juan Nacher
    Neurobiology, Cell Biology Department, Universitat de Valencia, Burjassot, Spain
    J Neurosci Res 81:753-61. 2005
    ..However, the expression of Pax 6 in astrocytes and certain mature neurons may indicate the existence of other roles for this transcription factor in this telencephalic region...
  5. ncbi request reprint NMDA receptor antagonist treatment increases the production of new neurons in the aged rat hippocampus
    Juan Nacher
    Laboratory of Neuroendocrinology, The Rockefeller University, 1230 York Avenue, New York, NY 10021, USA
    Neurobiol Aging 24:273-84. 2003
    ..Injection of the NMDA receptor antagonist to aged rats increases significantly the number of proliferating cells, new neurons and radial glia-like cells in the hippocampus...
  6. ncbi request reprint CRMP-4 expression in the adult cerebral cortex and other telencephalic areas of the lizard Podarcis hispanica
    Juan Nacher
    Neurobiologia, Biologia Celular, Facultad de Ciencias Biologicas, Universidad de Valencia, 46100 Burjassot, Valencia, Spain
    Brain Res Dev Brain Res 139:285-94. 2002
    ..Our results show for the first time the expression of CRMP-4 in a reptile brain, where it appears to be expressed in regions where adult neurogenesis and/or neurite outgrowth occur...
  7. ncbi request reprint Chronic non-invasive glucocorticoid administration decreases polysialylated neural cell adhesion molecule expression in the adult rat dentate gyrus
    Juan Nacher
    Neurobiology, Cell Biology Department, Universitat de Valencia, Dr Moliner, 50, Burjassot 46100, Spain
    Neurosci Lett 370:40-4. 2004
    ..Because CORT treatment reduces but does not eliminate PSA-NCAM expression, the present results do not exclude a permissive role for PSA-NCAM in CORT or CRS-induced structural plasticity in hippocampus...
  8. ncbi request reprint Distribution of PSA-NCAM expression in the amygdala of the adult rat
    J Nacher
    Laboratory of Neuroendocrinology, Rockefeller University, New York, NY 10021, USA
    Neuroscience 113:479-84. 2002
    ..PSA-NCAM expression in the lateral amygdala could indicate its participation in the plastic events that lead to the generation of emotional memories such as those related to fear conditioning...
  9. doi request reprint Divergent impact of the polysialyltransferases ST8SiaII and ST8SiaIV on polysialic acid expression in immature neurons and interneurons of the adult cerebral cortex
    J Nacher
    Cell Biology Department, Universitat de Valencia, Burjassot, Spain
    Neuroscience 167:825-37. 2010
    ..However, many of the immature granule neurons showed aberrant locations and morphology, suggesting a role of ST8SiaII in their terminal differentiation...
  10. ncbi request reprint Non-granule PSA-NCAM immunoreactive neurons in the rat hippocampus
    Juan Nacher
    Harold and Margaret Milliken Hatch Laboratory of Neuroendocrinology, Rockefeller University, York Avenue 1230, New York, NY 10021, USA
    Brain Res 930:1-11. 2002
    ..The presence of the polysialylated form of NCAM in these neurons could indicate that they are undergoing continuous remodeling during adulthood and may have an important role in hippocampal structural plasticity...
  11. ncbi request reprint PSA-NCAM expression in the piriform cortex of the adult rat. Modulation by NMDA receptor antagonist administration
    Juan Nacher
    Laboratory of Neuroendocrinology, The Rockefeller University, 1230 York Avenue, New York, NY 10021, USA
    Brain Res 927:111-21. 2002
    ..Similar to the hippocampus, NMDA receptors appear to play a critical role in these processes in the adult piriform cortex...
  12. ncbi request reprint Doublecortin expression in the adult rat telencephalon
    J Nacher
    Laboratory of Neuroendocrinology, The Rockefeller University, New York, NY 10021, USA
    Eur J Neurosci 14:629-44. 2001
    ..Given these results, we hypothesize that DCX expression in differentiated neurons could be related to its capacity for microtubule reorganization and that this fact could be linked to axonal outgrowth or synaptogenesis...
  13. ncbi request reprint NMDA receptor antagonist treatment induces a long-lasting increase in the number of proliferating cells, PSA-NCAM-immunoreactive granule neurons and radial glia in the adult rat dentate gyrus
    J Nacher
    Laboratory of Neuroendocrinology, The Rockefeller University, New York, NY 10021, USA
    Eur J Neurosci 13:512-20. 2001
    ..Thus, NMDA receptor antagonist treatment serves as a valuable tool to increase neurogenesis in the adult hippocampus without undesirable collateral deleterious effects...
  14. ncbi request reprint Chronic antidepressant treatment induces contrasting patterns of synaptophysin and PSA-NCAM expression in different regions of the adult rat telencephalon
    E Varea
    Neurobiology Unit and Program in Basic and Applied Neurosciences, Cell Biology Department, Universitat de Valencia, Spain
    Eur Neuropsychopharmacol 17:546-57. 2007
    ..The expression of these molecules is also affected in the entorhinal, the visual and the somatosensory cortices...
  15. ncbi request reprint N-methyl-d-aspartate receptor expression during adult neurogenesis in the rat dentate gyrus
    J Nacher
    Neurobiology Unit and Program in Basic and Applied Neurosciences, Cell Biology Department, Universitat de Valencia, Dr Moliner 50, Burjassot 46100, Spain
    Neuroscience 144:855-64. 2007
    ..However, an indirect effect through NMDA receptors located in other cell types should not be excluded...
  16. ncbi request reprint Widespread expression of rat collapsin response-mediated protein 4 in the telencephalon and other areas of the adult rat central nervous system
    J Nacher
    Laboratory of Neuroendocrinology, The Rockefeller University, New York, New York 10021, USA
    J Comp Neurol 424:628-39. 2000
    ..These cells did not express neuronal, astroglial, or microglial markers, although some of them also were immunoreactive for rip antibody, suggesting an oligodendroglial lineage...
  17. ncbi request reprint PSA-NCAM expression in the rat medial prefrontal cortex
    E Varea
    Neurobiology, Cell Biology Department, Universitat de Valencia, Dr Moliner, 50, 46100 Burjassot, Valencia, Spain
    Neuroscience 136:435-43. 2005
    ....
  18. doi request reprint Synaptic connectivity of serotonergic axons in the olfactory glomeruli of the rat olfactory bulb
    F J Gracia-Llanes
    Departamento de Biologia Celular, Facultad de Ciencias Biologicas, Universidad de Valencia, Burjasot, Valencia, Spain
    Neuroscience 169:770-80. 2010
    ..Altogether, our results suggest a complex action of the serotonergic system in the modulation of the bulbar circuitry...
  19. doi request reprint Effects of chronic fluoxetine treatment on the rat somatosensory cortex: activation and induction of neuronal structural plasticity
    R Guirado
    Cell Biology Department, Neurobiology Unit and Program in Basic and Applied Neurosciences, Universitat de Valencia, Spain
    Neurosci Lett 457:12-5. 2009
    ..These results indicate that, apart from the medial prefrontal cortex or the hippocampus, other cortical regions can respond to chronic antidepressant treatment undergoing neuronal structural plasticity...
  20. doi request reprint Alteration of inhibitory circuits in the somatosensory cortex of Ts65Dn mice, a model for Down's syndrome
    D Pérez-Cremades
    Department of Cell Biology, University of Valencia, Dr Moliner Street, 50, 46100 Burjassot, Valencia, Spain
    J Neural Transm 117:445-55. 2010
    ....
  21. ncbi request reprint Differential expression of suppressors of cytokine signaling-1, -2, and -3 in the rat hippocampus after seizure: implications for neuromodulation by gp130 cytokines
    D R Rosell
    Laboratory of Neuroendocrinology, The Rockefeller University, 1230 York Avenue, Box 165, New York, NY 10021, USA
    Neuroscience 122:349-58. 2003
    ..Since in our previous study we did not detect cytokine receptor expression in non-principal cells, it is unclear what elicits SOCS-3 expression in this population...
  22. ncbi request reprint "Arrested development". Immature, but not recently generated, neurons in the adult brain
    M Á Gómez-Climent
    Neurobiology Unit and Program in Basic and Applied Neurosciences, Cell Biology Dpt, Universitat de Valencia, Spain
    Arch Ital Biol 148:159-72. 2010
    ..The review is mainly focused on the population of immature neurons located in the layer II of certain cortical regions, but we will also describe similar populations found in other regions of the peripheral and central nervous systems...
  23. doi request reprint Distribution of the A3 subunit of the cyclic nucleotide-gated ion channels in the main olfactory bulb of the rat
    M Gutierrez-Mecinas
    Departamento de Biologia Celular, Unidad de Neurobiologia, Facultad de Ciencias Biologicas, Universidad de Valencia, Street Dr Moliner 50, Burjasot, Spain
    Neuroscience 153:1164-76. 2008
    ..Moreover, they can be involved in the function of the ensheathing glia and in the radial migration of immature cells through the bulbar layers...
  24. doi request reprint Characterization of a population of tyrosine hydroxylase-containing interneurons in the external plexiform layer of the rat olfactory bulb
    T Liberia
    Departamento de Biología Celular y Parasitología, Facultad de Ciencias Biologicas, Universidad de Valencia, C Dr Moliner, 50, E 46100 Burjassot, Spain
    Neuroscience 217:140-53. 2012
    ....
  25. doi request reprint GABAergic basal forebrain afferents innervate selectively GABAergic targets in the main olfactory bulb
    F J Gracia-Llanes
    Universidad de Valencia, Facultad de Ciencias Biologicas, Departamento de Biologia Celular, Unidad de Neurobiología Str Dr Moliner, 50 E 46 100 Burjasot Valencia, Spain
    Neuroscience 170:913-22. 2010
    ..Possible similarities of this pathway with the septo-hippocampal loop are discussed...
  26. doi request reprint Olfactory bulbectomy, but not odor conditioned aversion, induces the differentiation of immature neurons in the adult rat piriform cortex
    M Á Gómez-Climent
    Neurobiology Unit and Program in Basic and Applied Neurosciences, Cell Biology Department, Universitat de Valencia, Spain
    Neuroscience 181:18-27. 2011
    ..By contrast, these cells do not seem to play a crucial role in olfactory memory...
  27. ncbi request reprint Spatiotemporal distribution of gp130 cytokines and their receptors after status epilepticus: comparison with neuronal degeneration and microglial activation
    D R Rosell
    Laboratory of Neuroendocrinology, The Rockefeller University, 1230 York Avenue, Box 165, New York, NY 10021, USA
    Neuroscience 122:329-48. 2003
    ..Furthermore, we suggest that activity-dependent mechanisms may be involved in the regulation of cytokines expressed early, and that relatively late occurring cytokine expression may be elicited by injury-related stimuli...
  28. ncbi request reprint The lizard cerebral cortex as a model to study neuronal regeneration
    Carlos Lopez-Garcia
    Lab Neurobiologia Celular, Universidad de Valencia, Burjasot, Valencia, 46100, Spain
    An Acad Bras Cienc 74:85-104. 2002
    ..Thus the lizard cerebral cortex is a good model to study neuronal regeneration and the complex factors that regulate its neurogenetic, migratory and neo-synaptogenetic events...
  29. ncbi request reprint The role of N-methyl-D-asparate receptors in neurogenesis
    Juan Nacher
    Neurobiology Division, Department of Cell Biology, Universitat de Valencia, Dr Moliner, 50 Burjassot 46100, Spain
    Hippocampus 16:267-70. 2006
    ....
  30. ncbi request reprint Neural overexcitation and implication of NMDA and AMPA receptors in a mouse model of temporal lobe epilepsy implying zinc chelation
    María Isabel Domínguez
    Universidad de Valencia, Facultad de Ciencias Biologicas, Departamento de Biologia Celular, Unidad de Neurobiologia, Burjasot, Spain
    Epilepsia 47:887-99. 2006
    ..The objective of this work was to study the developing of the lesion in this model of temporal lobe epilepsy and the implications of the different types of glutamate receptors...
  31. ncbi request reprint Loss of input from the mossy cells blocks maturation of newly generated granule cells
    Ana Isabel Marqués-Marí
    Departamento de Biologia Celular, Unidad de Neurobiologia, Facultad de Ciencias Biologicas, Universidad de Valencia, E 46 100 Burjasot, Spain
    Hippocampus 17:510-24. 2007
    ..Thus, it is likely that the reorganization of the circuitry after the loss of the mossy cells facilitates the survival and incorporation of the newly generated granule cells...
  32. ncbi request reprint Cytochemical techniques for zinc and heavy metals localization in nerve cells
    Carlos Lopez-Garcia
    Neurobiology, Department of Cell Biology, University of Valencia, 46100 Burjassot, Valencia, Spain
    Microsc Res Tech 56:318-31. 2002
    ....
  33. ncbi request reprint PSA-NCAM immunocytochemistry in the cerebral cortex and other telencephalic areas of the lizard Podarcis hispanica: differential expression during medial cortex neuronal regeneration
    Carmen Ramirez-Castillejo
    Neurobiologia, Biologia Celular, Facultad de Ciencias Biologicas, Universidad de Valencia, 46100 Burjassot, Spain
    J Comp Neurol 453:145-56. 2002
    ..Our results show for the first time the expression of PSA-NCAM in a reptile brain, where it appears to participate in the migration and differentiation of granule neurons during adult neurogenesis and regeneration...
  34. ncbi request reprint Repeated restraint stress suppresses neurogenesis and induces biphasic PSA-NCAM expression in the adult rat dentate gyrus
    Kara Pham
    Laboratory of Neuroendocrinology, Rockefeller University, New York, New York 10021, USA
    Eur J Neurosci 17:879-86. 2003
    ..These studies may help us understand the basis for hippocampal shrinkage and raise questions about the ultimate reversibility of the effects of chronic stress...