Victoriano Mulero

Summary

Affiliation: University of Murcia
Country: Spain

Publications

  1. pmc Solute carrier 11a1 (Slc11a1; formerly Nramp1) regulates metabolism and release of iron acquired by phagocytic, but not transferrin-receptor-mediated, iron uptake
    Victoriano Mulero
    Department of Immunology and Bacteriology, Western Infirmary, University of Glasgow, Glasgow G11 6NT, Scotland, UK
    Biochem J 363:89-94. 2002
  2. ncbi request reprint The colony-stimulating factor-1 receptor is a specific marker of macrophages from the bony fish gilthead seabream
    Francisco J Roca
    Department of Cell Biology, Faculty of Biology, University of Murcia, 30100 Murcia, Spain
    Mol Immunol 43:1418-23. 2006
  3. ncbi request reprint The activation of gilthead seabream professional phagocytes by different PAMPs underlines the behavioural diversity of the main innate immune cells of bony fish
    M Pilar Sepulcre
    Department of Cell Biology, Faculty of Biology, University of Murcia, 30100 Murcia, Spain
    Mol Immunol 44:2009-16. 2007
  4. pmc TNF receptors regulate vascular homeostasis in zebrafish through a caspase-8, caspase-2 and P53 apoptotic program that bypasses caspase-3
    Raquel Espín
    Departmento de Biología Celular e Histología, Facultad de Biologia, Universidad de Murcia, 30100 Murcia, Spain
    Dis Model Mech 6:383-96. 2013
  5. pmc An orphan viral TNF receptor superfamily member identified in lymphocystis disease virus
    Sergio M Pontejo
    Centro de Biologia Molecular Severo Ochoa, Consejo Superior de Investigaciones Cientificas and Universidad Autonoma de Madrid, Cantoblanco, Madrid 28049, Spain
    Virol J 10:188. 2013
  6. pmc Testicular involution prior to sex change in gilthead seabream is characterized by a decrease in DMRT1 gene expression and by massive leukocyte infiltration
    Sergio Liarte
    Department of Cell Biology, Faculty of Biology, University of Murcia, Campus Universitario de Espinardo, Murcia, Spain
    Reprod Biol Endocrinol 5:20. 2007
  7. pmc A role for specific collagen motifs during wound healing and inflammatory response of fibroblasts in the teleost fish gilthead seabream
    Patricia Castillo-Briceño
    Department of Cell Biology and Histology, University of Murcia, Murcia 30100, Spain
    Mol Immunol 48:826-34. 2011
  8. pmc Profiling of infection specific mRNA transcripts of the European seabass Dicentrarchus labrax
    Elena Sarropoulou
    Institute of Marine Biology and Genetics, Hellenic Center of Marine Research, Iraklio, Crete, Greece
    BMC Genomics 10:157. 2009
  9. pmc Application of the dual-luciferase reporter assay to the analysis of promoter activity in Zebrafish embryos
    Francisca Alcaraz-Pérez
    Research Unit, Department of Surgery, University Hospital Virgen de la Arrixaca, 30120 Murcia, Spain
    BMC Biotechnol 8:81. 2008
  10. pmc Regulation of phagosomal iron release from murine macrophages by nitric oxide
    Victoriano Mulero
    Department of Immunology and Bacteriology, Western Infirmary, University of Glasgow, Glasgow, UK
    Biochem J 365:127-32. 2002

Collaborators

Detail Information

Publications38

  1. pmc Solute carrier 11a1 (Slc11a1; formerly Nramp1) regulates metabolism and release of iron acquired by phagocytic, but not transferrin-receptor-mediated, iron uptake
    Victoriano Mulero
    Department of Immunology and Bacteriology, Western Infirmary, University of Glasgow, Glasgow G11 6NT, Scotland, UK
    Biochem J 363:89-94. 2002
    ....
  2. ncbi request reprint The colony-stimulating factor-1 receptor is a specific marker of macrophages from the bony fish gilthead seabream
    Francisco J Roca
    Department of Cell Biology, Faculty of Biology, University of Murcia, 30100 Murcia, Spain
    Mol Immunol 43:1418-23. 2006
    ..In addition, the functional characterisation of the CSF-1R and its ligand may shed light into the mechanisms of proliferation and the pathways of differentiation of macrophages in bony fish...
  3. ncbi request reprint The activation of gilthead seabream professional phagocytes by different PAMPs underlines the behavioural diversity of the main innate immune cells of bony fish
    M Pilar Sepulcre
    Department of Cell Biology, Faculty of Biology, University of Murcia, 30100 Murcia, Spain
    Mol Immunol 44:2009-16. 2007
    ..These results suggest different roles for professional phagocytes of fish in the recognition and elimination of pathogens and in the regulation of adaptive immune responses...
  4. pmc TNF receptors regulate vascular homeostasis in zebrafish through a caspase-8, caspase-2 and P53 apoptotic program that bypasses caspase-3
    Raquel Espín
    Departmento de Biología Celular e Histología, Facultad de Biologia, Universidad de Murcia, 30100 Murcia, Spain
    Dis Model Mech 6:383-96. 2013
    ..We have identified an evolutionarily conserved apoptotic pathway involved in vascular homeostasis that provides new therapeutic targets for the control of inflammation- and tumor-driven angiogenesis...
  5. pmc An orphan viral TNF receptor superfamily member identified in lymphocystis disease virus
    Sergio M Pontejo
    Centro de Biologia Molecular Severo Ochoa, Consejo Superior de Investigaciones Cientificas and Universidad Autonoma de Madrid, Cantoblanco, Madrid 28049, Spain
    Virol J 10:188. 2013
    ..Analysis of the genome of LCDV-C showed it to encode a protein named LDVICp016 with similarities to the Tumour necrosis factor receptor (TNFR) superfamily with immunomodulatory potential...
  6. pmc Testicular involution prior to sex change in gilthead seabream is characterized by a decrease in DMRT1 gene expression and by massive leukocyte infiltration
    Sergio Liarte
    Department of Cell Biology, Faculty of Biology, University of Murcia, Campus Universitario de Espinardo, Murcia, Spain
    Reprod Biol Endocrinol 5:20. 2007
    ..Special attention has been paid to the testicular degenerative process which is particularly active in the last stage of the second RC probably due to the immediacy of the sex change process...
  7. pmc A role for specific collagen motifs during wound healing and inflammatory response of fibroblasts in the teleost fish gilthead seabream
    Patricia Castillo-Briceño
    Department of Cell Biology and Histology, University of Murcia, Murcia 30100, Spain
    Mol Immunol 48:826-34. 2011
    ..These data suggest that specific collagen motifs are involved in the regulation of the inflammatory and healing responses of teleost fish...
  8. pmc Profiling of infection specific mRNA transcripts of the European seabass Dicentrarchus labrax
    Elena Sarropoulou
    Institute of Marine Biology and Genetics, Hellenic Center of Marine Research, Iraklio, Crete, Greece
    BMC Genomics 10:157. 2009
    ..The analysis of expressed sequence tags (EST) is an efficient and easy approach for gene discovery, comparative genomics and for examining gene expression in specific tissues in a qualitative and quantitative way...
  9. pmc Application of the dual-luciferase reporter assay to the analysis of promoter activity in Zebrafish embryos
    Francisca Alcaraz-Pérez
    Research Unit, Department of Surgery, University Hospital Virgen de la Arrixaca, 30120 Murcia, Spain
    BMC Biotechnol 8:81. 2008
    ..Although this strategy has proved very useful, it does not allow the promoter and gene function to be analyzed in the context of the whole organism...
  10. pmc Regulation of phagosomal iron release from murine macrophages by nitric oxide
    Victoriano Mulero
    Department of Immunology and Bacteriology, Western Infirmary, University of Glasgow, Glasgow, UK
    Biochem J 365:127-32. 2002
    ....
  11. doi request reprint Molecular cloning, phylogenetic analysis and functional characterization of soluble Toll-like receptor 5 in gilthead seabream, Sparus aurata
    Iciar Munoz
    Department of Cell Biology and Histology, Faculty of Biology, University of Murcia, 30100 Murcia, Spain
    Fish Shellfish Immunol 35:36-45. 2013
    ..Collectively, these results suggest that sbTLR5S plays an important role in modulating the flagellin-mediated immune response in seabream...
  12. doi request reprint Recombinant TNFα as oral vaccine adjuvant protects European sea bass against vibriosis: insights into the role of the CCL25/CCR9 axis
    Jorge Galindo-Villegas
    Department of Cell Biology and Histology, Faculty of Biology, University of Murcia, 30100 Murcia, Spain
    Fish Shellfish Immunol 35:1260-71. 2013
    ..Ex-vivo, chemotaxis analyses confirmed these findings. Together, our results demonstrate that improved oral vaccines targeting key cytokines may provide a means to selectively modulate fish immune defence. ..
  13. doi request reprint 17α-Ethynylestradiol alters the immune response of the teleost gilthead seabream (Sparus aurata L.) both in vivo and in vitro
    Isabel Cabas
    Department of Cell Biology and Histology, Faculty of Biology, University of Murcia, 30100 Murcia, Spain
    Dev Comp Immunol 36:547-56. 2012
    ..Taken together, our results suggest that EE(2) might alter the capacity of fish to appropriately respond to infection although it does not behave as an immunosuppressor...
  14. ncbi request reprint Molecular and functional characterization of gilthead seabream Sparus aurata caspase-1: the first identification of an inflammatory caspase in fish
    Gloria Lopez-Castejon
    Department of Cell Biology, Faculty of Biology, University of Murcia, 30100 Murcia, Spain
    Mol Immunol 45:49-57. 2008
    ..Finally, seabream fibroblast cell line SAF-1 and primary leukocytes showed endogenous caspase-1 activity, which was almost completely inhibited by a caspase-1 specific inhibitor...
  15. ncbi request reprint Professional phagocytic granulocytes of the bony fish gilthead seabream display functional adaptation to testicular microenvironment
    Elena Chaves-Pozo
    Department of Cell Biology, Faculty of Biology, University of Murcia, Campus Universitario de Espinardo, 30100 Murcia, Spain
    J Leukoc Biol 78:345-51. 2005
    ....
  16. ncbi request reprint The type II interleukin-1 receptor (IL-1RII) of the bony fish gilthead seabream Sparus aurata is strongly induced after infection and tightly regulated at transcriptional and post-transcriptional levels
    Gloria Lopez-Castejon
    Department of Cell Biology, Faculty of Biology, University of Murcia, 30100 Murcia, Spain
    Mol Immunol 44:2772-80. 2007
    ..Finally, the seabream IL-1RII was localized in the plasma membrane when expressed in HEK293 cells and was able to bind IL-1beta...
  17. pmc Histamine is stored in mast cells of most evolutionarily advanced fish and regulates the fish inflammatory response
    Ivan Mulero
    Department of Cell Biology, Faculty of Biology, University of Murcia, 30100 Murcia, Spain
    Proc Natl Acad Sci U S A 104:19434-9. 2007
    ..This same feature seems to have developed independently in Perciform fish much more recently in the Lower Eocene, between 55 and 45 million years ago, a short period during which the great majority of Percomorph families appeared...
  18. ncbi request reprint Characterization of macrophages from the bony fish gilthead seabream using an antibody against the macrophage colony-stimulating factor receptor
    Ivan Mulero
    Department of Cell Biology and Histology, Faculty of Biology, University of Murcia, 30100 Murcia, Spain
    Dev Comp Immunol 32:1151-9. 2008
    ..Finally, as the epitope recognized by the anti-Mcsfr is well conserved, we illustrate the potential usefulness of this antibody in other teleost species, such as the European seabass...
  19. doi request reprint Vaccination of larvae of the bony fish gilthead seabream reveals a lack of correlation between lymphocyte development and adaptive immunocompetence
    Ivan Mulero
    Department of Cell Biology and Histology, Faculty of Biology, University of Murcia, 30100 Murcia, Spain
    Mol Immunol 45:2981-9. 2008
    ....
  20. doi request reprint Collagen regulates the activation of professional phagocytes of the teleost fish gilthead seabream
    Patricia Castillo-Briceño
    Department of Cell Biology and Histology, Faculty of Biology, University of Murcia, 30100 Murcia, Spain
    Mol Immunol 46:1409-15. 2009
    ..Therefore, we propose that, besides to the well-established response to infection, the innate immune system of fish is able to respond to tissue injury...
  21. ncbi request reprint The antimicrobial peptides piscidins are stored in the granules of professional phagocytic granulocytes of fish and are delivered to the bacteria-containing phagosome upon phagocytosis
    Ivan Mulero
    Department of Cell Biology and Histology, Faculty of Biology, University of Murcia, 30100 Murcia, Spain
    Dev Comp Immunol 32:1531-8. 2008
    ....
  22. doi request reprint Evolutionary conserved pro-inflammatory and antigen presentation functions of zebrafish IFNγ revealed by transcriptomic and functional analysis
    Azucena López-Muñoz
    Department of Cell Biology and Histology, Faculty of Biology, University of Murcia, 30100 Murcia, Spain
    Mol Immunol 48:1073-83. 2011
    ....
  23. doi request reprint TLR agonists extend the functional lifespan of professional phagocytic granulocytes in the bony fish gilthead seabream and direct precursor differentiation towards the production of granulocytes
    Maria P Sepulcre
    Department of Cell Biology and Histology, Faculty of Biology, University of Murcia, Campus Universitario de Espinardo, 30100 Murcia, Spain
    Mol Immunol 48:846-59. 2011
    ..These results demonstrated that the extension of neutrophil lifespan by microbial products is conserved in lower vertebrates although the magnitude of the response is much higher in fish...
  24. ncbi request reprint Distribution of the professional phagocytic granulocytes of the bony fish gilthead seabream (Sparus aurata L.) during the ontogeny of lymphomyeloid organs and pathogen entry sites
    Ivan Mulero
    Department of Cell Biology, Faculty of Biology, University of Murcia, Campus Universitario Espinardo, 30100 Murcia, Spain
    Dev Comp Immunol 31:1024-33. 2007
    ..In the spleen and in the thymus, AGs were observed much later (62 dph) and appeared scattered. AGs were also observed in the gill lamella and the posterior intestine near the anus throughout development...
  25. ncbi request reprint Vibrio anguillarum evades the immune response of the bony fish sea bass (Dicentrarchus labrax L.) through the inhibition of leukocyte respiratory burst and down-regulation of apoptotic caspases
    M Pilar Sepulcre
    Department of Cell Biology, Faculty of Biology, University of Murcia, 30100 Murcia, Spain
    Mol Immunol 44:3751-7. 2007
    ..These results suggest that the virulence mechanisms of V. anguillarum in sea bass involve the inhibition of leukocyte respiratory burst and apoptosis, and thereby providing a safe haven for growth...
  26. doi request reprint Estrogen signaling through the G protein-coupled estrogen receptor regulates granulocyte activation in fish
    Isabel Cabas
    Department of Cell Biology and Histology, Faculty of Biology, Regional Campus of International Excellence Campus Mare Nostrum, University of Murcia, 30100 Murcia, Spain
    J Immunol 191:4628-39. 2013
    ....
  27. ncbi request reprint Post-transcriptional regulation of cytokine genes in fish: A role for conserved AU-rich elements located in the 3'-untranslated region of their mRNAs
    Francisco J Roca
    Department of Cell Biology, Faculty of Biology, University of Murcia, 30100 Murcia, Spain
    Mol Immunol 44:472-8. 2007
    ..Both cytokine mRNAs were unstable with an estimated half-life of about 45 min in control and activated cells...
  28. doi request reprint Dietary intake of 17α-ethinylestradiol promotes leukocytes infiltration in the gonad of the hermaphrodite gilthead seabream
    Isabel Cabas
    Department of Cell Biology and Histology, Faculty of Biology, University of Murcia, 30100 Murcia, Spain
    Mol Immunol 48:2079-86. 2011
    ..Moreover, the dietary intake of EE(2) promoted a dose-dependent up-regulation of the expression of genes coding for cytokines, chemokines and adhesion molecules correlated with a leukocyte infiltration...
  29. pmc Regulation of immunity and disease resistance by commensal microbes and chromatin modifications during zebrafish development
    Jorge Galindo-Villegas
    Departamento de Biología Celular e Histología, Universidad de Murcia, 30100 Murcia, Spain
    Proc Natl Acad Sci U S A 109:E2605-14. 2012
    ....
  30. ncbi request reprint Identification and functional characterization of a new IL-1 family member, IL-1Fm2, in most evolutionarily advanced fish
    Diego Angosto
    1Departamento de Biolog a Celular e Histolog a, Facultad de Biolog a, Universidad de Murcia, Murcia, Spain
    Innate Immun . 2013
    ..These results demonstrate an important role of IL-1Fm2 in the regulation of fish immune responses, shed light on the evolution of the IL-1 family in vertebrates and point to the complexity of this cytokine family...
  31. ncbi request reprint ATP Modulates Acute Inflammation In Vivo through Dual Oxidase 1-Derived H2O2 Production and NF-κB Activation
    Sofia de Oliveira
    Laboratório de Carlota Saldanha, Instituto de Medicina Molecular, 1649 028 Lisbon, Portugal Instituto de Bioquímica, Faculdade de Medicina, Universidade de Lisboa, 1649 028 Lisbon, Portugal Departamento de Biología Celular e Histología, Facultad de Biologia, Universidad de Murcia, 30100 Murcia, Spain
    J Immunol 192:5710-9. 2014
    ....
  32. ncbi request reprint Characterization of ATP-gated P2X7 receptors in fish provides new insights into the mechanism of release of the leaderless cytokine interleukin-1 beta
    Gloria Lopez-Castejon
    Department of Cell Biology, Faculty of Biology, University of Murcia, 30100 Murcia, Spain
    Mol Immunol 44:1286-99. 2007
    ....
  33. ncbi request reprint Acidophilic granulocytes of the marine fish gilthead seabream (Sparus aurata L.) produce interleukin-1beta following infection with Vibrio anguillarum
    Elena Chaves-Pozo
    Department of Cell Biology, Faculty of Biology, University of Murcia, Campus Universitario de Espinardo, 30100 Murcia, Spain
    Cell Tissue Res 316:189-95. 2004
    ..A rapid mobilization of such cells from the head-kidney to the site of inflammation following infection with V. anguillarum was also observed...
  34. pmc Tnfa signaling through tnfr2 protects skin against oxidative stress-induced inflammation
    Sergio Candel
    Departamento de Biología Celular e Histología, Facultad de Biologia, Universidad de Murcia, Murcia, Spain Instituto Murciano de Investigación Biosanitaria IMIB, Murcia, Spain
    PLoS Biol 12:e1001855. 2014
    ..These results reveal a crucial role for TNFα/TNFR2 axis in the protection of the skin against DUOX1-mediated oxidative stress and could establish new therapeutic targets for skin inflammatory disorders...
  35. ncbi request reprint An overview of cell renewal in the testis throughout the reproductive cycle of a seasonal breeding teleost, the gilthead seabream (Sparus aurata L)
    Elena Chaves-Pozo
    Department of Cell Biology, Faculty of Biology, University of Murcia, Campus Universitario de Espinardo, 30100 Murcia, Spain
    Biol Reprod 72:593-601. 2005
    ..This proliferative pattern was correlated with the gonadosomatic index, testicular morphology, and testicular and gonad areas, suggesting that complex mechanisms operate in the regulation of gonocyte proliferation in hermaphrodite fish...
  36. ncbi request reprint Toll-like receptor 22 of gilthead seabream, Sparus aurata: Molecular cloning, expression profiles and post-transcriptional regulation
    Iciar Munoz
    Departamento de Biología Celular e Histología, Facultad de Biologia, Universidad de Murcia, Murcia, Spain Instituto Murciano de Investigación Biosanitaria IMIB, Murcia, Spain Electronic address
    Dev Comp Immunol 44:173-9. 2014
    ..Taken together, our results suggest that sbTLR22 is involved in bacterial infection and might sense bacterial PAMPs. ..
  37. ncbi request reprint Molecular cloning and expression analysis of tumor necrosis factor alpha from a marine fish reveal its constitutive expression and ubiquitous nature
    Jesús García-Castillo
    Department of Cell Biology, Faculty of Biology, University of Murcia, 30100 Murcia, Spain
    Immunogenetics 54:200-7. 2002
    ..The putative role of three AU-rich endotoxin-responsive motifs (AREs) of seabream TNF alpha mRNA, found within two phylogenetically conserved protein binding regions, is discussed...
  38. ncbi request reprint Production and mechanism of secretion of interleukin-1beta from the marine fish gilthead seabream
    Pablo Pelegrin
    Department of Cell Biology, Faculty of Biology, University of Murcia, Campus Universitario de Espinardo, 30100, Murcia, Spain
    Dev Comp Immunol 28:229-37. 2004
    ..Notably, the post-translational processing of IL-1beta by SAF-1 cells is abrogated by a specific ICE inhibitor...