Victoriano Mulero


Affiliation: University of Murcia
Country: Spain


  1. López Muñoz A, Nicolas F, García Moreno D, Pérez Oliva A, Navarro Mendoza M, Hernández Oñate M, et al. An Adult Zebrafish Model Reveals that Mucormycosis Induces Apoptosis of Infected Macrophages. Sci Rep. 2018;8:12802 pubmed publisher
    ..The induction of macrophage apoptosis, therefore, might represent a key virulence mechanism of these fungal pathogens, providing novel targets for therapeutic intervention in this lethal infection. ..
  2. Angosto D, Montero J, López Muñoz A, Alcaraz Pérez F, Bird S, Sarropoulou E, et al. Identification and functional characterization of a new IL-1 family member, IL-1Fm2, in most evolutionarily advanced fish. Innate Immun. 2014;20:487-500 pubmed publisher
    ..These results demonstrate an important role of IL-1Fm2 in the regulation of fish immune responses, shed light on the evolution of the IL-1 family in vertebrates and point to the complexity of this cytokine family. ..
  3. Garcia Garcia E, Gómez González N, Meseguer J, García Ayala A, Mulero V. Histamine regulates the inflammatory response of the tunicate Styela plicata. Dev Comp Immunol. 2014;46:382-91 pubmed publisher
    ..These results provide for the first time clear evidence for the involvement of histamine in the regulation of inflammation and host defense in tunicates. ..
  4. Gómez González N, Garcia Garcia E, Montero J, García Alcazar A, Meseguer J, García Ayala A, et al. Isolation of mast cells from the peritoneal exudate of the teleost fish gilthead sea bream (Sparus aurata L.). Fish Shellfish Immunol. 2014;40:225-32 pubmed publisher
    ..This fish mast cells separation protocol is a stepping stone for further studies addressing the evolution of vertebrate inflammatory mechanisms. ..
  5. Angosto D, López Muñoz A, García Alcazar A, Meseguer J, Sepulcre M, Mulero V. Aluminum is a powerful adjuvant in teleost fish despite failing to induce interleukin-1β release. Dev Comp Immunol. 2018;85:18-24 pubmed publisher
  6. Espín Palazón R, Stachura D, Campbell C, García Moreno D, Del Cid N, Kim A, et al. Proinflammatory signaling regulates hematopoietic stem cell emergence. Cell. 2014;159:1070-1085 pubmed publisher
    ..These results demonstrate that proinflammatory signaling, in the absence of infection, is utilized by the developing embryo to generate the lineal precursors of the adult hematopoietic system. ..
  7. Galindo Villegas J, García Alcazar A, Meseguer J, Mulero V. Aluminum adjuvant potentiates gilthead seabream immune responses but induces toxicity in splenic melanomacrophage centers. Fish Shellfish Immunol. 2018;: pubmed publisher
    ..Therefore, our data support adjuvant inclusion, but strongly suggest that use of aluminium must be further explored in detail before it might benefit the rational design of new vaccination strategies in aquaculture. ..
  8. de Oliveira S, Lopez Muñoz A, Martínez Navarro F, Galindo Villegas J, Mulero V, Calado Ã. Cxcl8-l1 and Cxcl8-l2 are required in the zebrafish defense against Salmonella Typhimurium. Dev Comp Immunol. 2015;49:44-8 pubmed publisher
  9. Galindo Villegas J, Garcia Garcia E, Mulero V. Role of histamine in the regulation of intestinal immunity in fish. Dev Comp Immunol. 2016;64:178-86 pubmed publisher

More Information


  1. Montero J, Gómez Abellán V, Arizcun M, Mulero V, Sepulcre M. Prostaglandin E2 promotes M2 polarization of macrophages via a cAMP/CREB signaling pathway and deactivates granulocytes in teleost fish. Fish Shellfish Immunol. 2016;55:632-41 pubmed publisher
    ..Our data identify for the first time a role for professional phagocyte-derived-PGE2 in the resolution of inflammation in fish and highlight key differences in the PGE2 signaling pathway in macrophages and granulocytes. ..
  2. Boltaña S, Castellana B, Goetz G, Tort L, Teles M, Mulero V, et al. Extending Immunological Profiling in the Gilthead Sea Bream, Sparus aurata, by Enriched cDNA Library Analysis, Microarray Design and Initial Studies upon the Inflammatory Response to PAMPs. Int J Mol Sci. 2017;18: pubmed publisher
    ..We have developed and validated an oligonucleotide microarray (SAQ) that provides a platform enriched for the study of gene expression in S. aurata with an emphasis upon immunity and the immune response. ..
  3. Sarropoulou E, Sepulcre P, Poisa Beiro L, Mulero V, Meseguer J, Figueras A, et al. Profiling of infection specific mRNA transcripts of the European seabass Dicentrarchus labrax. BMC Genomics. 2009;10:157 pubmed publisher
    ..In addition some of the potentially interesting genes identified by in silico analysis and confirmed by real-time PCR are putative biomarkers for bacterial and viral infections in fish. ..
  4. Alcaraz Pérez F, Mulero V, Cayuela M. Application of the dual-luciferase reporter assay to the analysis of promoter activity in Zebrafish embryos. BMC Biotechnol. 2008;8:81 pubmed publisher
    ..Among others, the assay allows a rapid and quantitative measurement of the effects of particular genes or drugs in a given promoter in the context of a whole organism and it can also be used in high throughput screening experiments. ..
  5. López Muñoz A, Liarte S, Gómez González N, Cabas I, Meseguer J, García Ayala A, et al. Estrogen receptor 2b deficiency impairs the antiviral response of zebrafish. Dev Comp Immunol. 2015;53:55-62 pubmed publisher
    ..All together, these results uncover an important role for E2 and Esr signaling in the fine-tuning of sexual hormone balance and the antiviral response of vertebrates. ..
  6. Candel S, Tyrkalska S, García Moreno D, Meseguer J, Mulero V. Identification of Evolutionarily Conserved Md1 Splice Variants That Regulate Innate Immunity through Differential Induction of NF-?B. J Immunol. 2016;197:1379-88 pubmed publisher
  7. Candel S, Sepulcre M, Espín Palazón R, Tyrkalska S, de Oliveira S, Meseguer J, et al. Md1 and Rp105 regulate innate immunity and viral resistance in zebrafish. Dev Comp Immunol. 2015;50:155-65 pubmed publisher
    ..These results shed light on the evolutionary history of Md1 and Rp105 and uncover a previously unappreciated function of these molecules in the regulation of innate immunity. ..
  8. de Oliveira S, López Muñoz A, Candel S, Pelegrin P, Calado A, Mulero V. ATP modulates acute inflammation in vivo through dual oxidase 1-derived H2O2 production and NF-?B activation. J Immunol. 2014;192:5710-9 pubmed publisher