Maria J Moreno-Aliaga

Summary

Affiliation: University of Navarra
Country: Spain

Publications

  1. ncbi request reprint Sp1-mediated transcription is involved in the induction of leptin by insulin-stimulated glucose metabolism
    M J Moreno-Aliaga
    Department of Physiology and Nutrition, School of Pharmacy, University of Navarra, Pamplona, Spain
    J Mol Endocrinol 38:537-46. 2007
  2. pmc Differential proinflammatory and oxidative stress response and vulnerability to metabolic syndrome in habitual high-fat young male consumers putatively predisposed by their genetic background
    Pedro González-Muniesa
    Department of Nutrition, Food Sciences and Physiology, University of Navarra, 31008 Pamplona, Spain
    Int J Mol Sci 14:17238-55. 2013
  3. ncbi request reprint Effects of a beta3-adrenergic agonist on glucose uptake and leptin expression and secretion in cultured adipocytes from lean and overweight (cafeteria) rats
    Maria J Moreno-Aliaga
    Department of Physiology and Nutrition, University of Navarra, 31008 Pamplona, Spain
    Biochem Biophys Res Commun 291:1201-7. 2002
  4. doi request reprint Regulation of adipokine secretion by n-3 fatty acids
    Maria J Moreno-Aliaga
    Department of Nutrition, Food Science, Physiology and Toxicology, University of Navarra, Pamplona, Spain
    Proc Nutr Soc 69:324-32. 2010
  5. doi request reprint Lipoic acid administration prevents nonalcoholic steatosis linked to long-term high-fat feeding by modulating mitochondrial function
    M Pilar Valdecantos
    Department of Nutrition, Food Science, Physiology and Toxicology, University of Navarra, 31008 Pamplona, Spain
    J Nutr Biochem 23:1676-84. 2012
  6. doi request reprint Lipoic acid inhibits leptin secretion and Sp1 activity in adipocytes
    Pedro L Prieto-Hontoria
    Department of Nutrition, Food Science, Physiology and Toxicology, University of Navarra, Pamplona, Spain
    Mol Nutr Food Res 55:1059-69. 2011
  7. ncbi request reprint Eicosapentaenoic acid actions on adiposity and insulin resistance in control and high-fat-fed rats: role of apoptosis, adiponectin and tumour necrosis factor-alpha
    Patricia Pérez-Matute
    Department of Physiology and Nutrition, University of Navarra, 31008 Pamplona, Spain
    Br J Nutr 97:389-98. 2007
  8. pmc Effects of lipoic acid on lipolysis in 3T3-L1 adipocytes
    Marta Fernández-Galilea
    Department of Nutrition, Food Science, Physiology and Toxicology, University of Navarra, Pamplona, Spain
    J Lipid Res 53:2296-306. 2012
  9. ncbi request reprint Effects of lipoic acid on AMPK and adiponectin in adipose tissue of low- and high-fat-fed rats
    Pedro L Prieto-Hontoria
    Department of Nutrition, Food Science, Physiology and Toxicology, University of Navarra, Pamplona, Spain
    Eur J Nutr 52:779-87. 2013
  10. ncbi request reprint Eicosapentaenoic fatty acid increases leptin secretion from primary cultured rat adipocytes: role of glucose metabolism
    Patricia Pérez-Matute
    Department of Physiology and Nutrition, University of Navarra, 31008 Pamplona, Spain
    Am J Physiol Regul Integr Comp Physiol 288:R1682-8. 2005

Collaborators

Detail Information

Publications46

  1. ncbi request reprint Sp1-mediated transcription is involved in the induction of leptin by insulin-stimulated glucose metabolism
    M J Moreno-Aliaga
    Department of Physiology and Nutrition, School of Pharmacy, University of Navarra, Pamplona, Spain
    J Mol Endocrinol 38:537-46. 2007
    ..Together, these findings support a key role for Sp1 in the transcriptional activation of the leptin gene promoter by insulin-mediated glucose metabolism...
  2. pmc Differential proinflammatory and oxidative stress response and vulnerability to metabolic syndrome in habitual high-fat young male consumers putatively predisposed by their genetic background
    Pedro González-Muniesa
    Department of Nutrition, Food Sciences and Physiology, University of Navarra, 31008 Pamplona, Spain
    Int J Mol Sci 14:17238-55. 2013
    ....
  3. ncbi request reprint Effects of a beta3-adrenergic agonist on glucose uptake and leptin expression and secretion in cultured adipocytes from lean and overweight (cafeteria) rats
    Maria J Moreno-Aliaga
    Department of Physiology and Nutrition, University of Navarra, 31008 Pamplona, Spain
    Biochem Biophys Res Commun 291:1201-7. 2002
    ..However, neither the cafeteria diet nor the Trecadrine treatment significantly alters the ability of adipocytes to increase leptin secretion in response to insulin...
  4. doi request reprint Regulation of adipokine secretion by n-3 fatty acids
    Maria J Moreno-Aliaga
    Department of Nutrition, Food Science, Physiology and Toxicology, University of Navarra, Pamplona, Spain
    Proc Nutr Soc 69:324-32. 2010
    ....
  5. doi request reprint Lipoic acid administration prevents nonalcoholic steatosis linked to long-term high-fat feeding by modulating mitochondrial function
    M Pilar Valdecantos
    Department of Nutrition, Food Science, Physiology and Toxicology, University of Navarra, 31008 Pamplona, Spain
    J Nutr Biochem 23:1676-84. 2012
    ..The reduction in mitochondrial energy efficiency could also explain, at least in part, the beneficial effects of lipoic acid not only in fatty liver but also in preventing excessive body weight gain...
  6. doi request reprint Lipoic acid inhibits leptin secretion and Sp1 activity in adipocytes
    Pedro L Prieto-Hontoria
    Department of Nutrition, Food Science, Physiology and Toxicology, University of Navarra, Pamplona, Spain
    Mol Nutr Food Res 55:1059-69. 2011
    ..The aim of this study was to examine in vivo and in vitro the effects of LA on leptin production, as well as to elucidate the mechanisms and signalling pathways involved in LA actions...
  7. ncbi request reprint Eicosapentaenoic acid actions on adiposity and insulin resistance in control and high-fat-fed rats: role of apoptosis, adiponectin and tumour necrosis factor-alpha
    Patricia Pérez-Matute
    Department of Physiology and Nutrition, University of Navarra, 31008 Pamplona, Spain
    Br J Nutr 97:389-98. 2007
    ..Adiposity-corrected adiponectin plasma levels were increased by EPA. These actions on both TNFalpha and adiponectin could explain the beneficial effects of EPA on insulin resistance induced by the cafeteria diet...
  8. pmc Effects of lipoic acid on lipolysis in 3T3-L1 adipocytes
    Marta Fernández-Galilea
    Department of Nutrition, Food Science, Physiology and Toxicology, University of Navarra, Pamplona, Spain
    J Lipid Res 53:2296-306. 2012
    ..Together, these data suggest that the lipolytic actions of LA are mainly mediated by phosphorylation of HSL through cAMP-mediated activation of protein kinase A probably through the inhibition of AdPLA and prostaglandin E(2)...
  9. ncbi request reprint Effects of lipoic acid on AMPK and adiponectin in adipose tissue of low- and high-fat-fed rats
    Pedro L Prieto-Hontoria
    Department of Nutrition, Food Science, Physiology and Toxicology, University of Navarra, Pamplona, Spain
    Eur J Nutr 52:779-87. 2013
    ..AMP-activated protein kinase (AMPK) is a key enzyme involved in cellular energy homeostasis. Activation of AMPK has been considered as a target to reverse the metabolic abnormalities associated with obesity and type 2 diabetes...
  10. ncbi request reprint Eicosapentaenoic fatty acid increases leptin secretion from primary cultured rat adipocytes: role of glucose metabolism
    Patricia Pérez-Matute
    Department of Physiology and Nutrition, University of Navarra, 31008 Pamplona, Spain
    Am J Physiol Regul Integr Comp Physiol 288:R1682-8. 2005
    ..84, P < 0.01). Together, the results suggest that EPA, like insulin, stimulates leptin production by increasing the nonanaerobic/oxidative metabolism of glucose...
  11. doi request reprint Cardiotrophin-1 is a key regulator of glucose and lipid metabolism
    Maria J Moreno-Aliaga
    Department of Nutrition, Food Sciences, Physiology and Toxicology, University of Navarra, 31008 Pamplona, Spain
    Cell Metab 14:242-53. 2011
    ..We conclude that CT-1 is a master regulator of fat and glucose metabolism with potential applications for treatment of obesity and insulin resistance...
  12. doi request reprint Effects of eicosapentaenoic acid ethyl ester on visfatin and apelin in lean and overweight (cafeteria diet-fed) rats
    Nerea Pérez-Echarri
    Department of Nutrition, Food Science, Physiology and Toxicology, University of Navarra, 31008 Pamplona, Spain
    Br J Nutr 101:1059-67. 2009
    ....
  13. ncbi request reprint Lipoic acid inhibits adiponectin production in 3T3-L1 adipocytes
    Pedro L Prieto-Hontoria
    Department of Nutrition, Food Science and Physiology, University of Navarra, Pamplona, Spain
    J Physiol Biochem 69:595-600. 2013
    ....
  14. ncbi request reprint Predictor factors for childhood obesity in a Spanish case-control study
    Maria C Ochoa
    Department of Physiology and Nutrition, University of Navarra, Pamplona, Spain
    Nutrition 23:379-84. 2007
    ....
  15. doi request reprint Eicosapentaenoic acid inhibits tumour necrosis factor-α-induced lipolysis in murine cultured adipocytes
    Silvia Lorente-Cebrián
    Department of Nutrition, Food Science, Physiology and Toxicology, University of Navarra, 31008 Pamplona, Spain
    J Nutr Biochem 23:218-27. 2012
    ..These findings suggest that EPA inhibits proinflammatory cytokine-induced lipolysis in adipocytes. This effect might contribute to explain the insulin-sensitizing properties of EPA...
  16. doi request reprint Fat intake leads to differential response of rat adipocytes to glucose, insulin and ascorbic acid
    Diego F García-Díaz
    Department of Nutrition and Food Sciences, Physiology and Toxicology, University of Navarra, C Irunlarrea 1, 31008 Pamplona, Spain
    Exp Biol Med (Maywood) 237:407-16. 2012
    ....
  17. ncbi request reprint Role of omega-3 fatty acids in obesity, metabolic syndrome, and cardiovascular diseases: a review of the evidence
    Silvia Lorente-Cebrián
    Department of Nutrition, Food Science and Physiology, University of Navarra, Pamplona, Spain
    J Physiol Biochem 69:633-51. 2013
    ..However, more clinical trials are necessary to recommend the most effective dosages and formulas (type of n-3 LC-PUFA, EPA/DHA ratio) for specific pathologies. ..
  18. doi request reprint A dysregulation in CES1, APOE and other lipid metabolism-related genes is associated to cardiovascular risk factors linked to obesity
    M Pilar Marrades
    Department of Nutrition, Food Sciences, Physiology and Toxicology, University of Navarra, Pamplona, Spain
    Obes Facts 3:312-8. 2010
    ....
  19. doi request reprint Lipoic acid improves mitochondrial function in nonalcoholic steatosis through the stimulation of sirtuin 1 and sirtuin 3
    M Pilar Valdecantos
    Department of Nutrition, Food Science, Physiology and Toxicology, University of Navarra, Pamplona, Spain
    Obesity (Silver Spring) 20:1974-83. 2012
    ....
  20. ncbi request reprint High-fat feeding period affects gene expression in rat white adipose tissue
    I P Lopez
    Department of Biochemistry and Molecular Biology, University of Navarra, Spain
    Mol Cell Biochem 275:109-15. 2005
    ....
  21. ncbi request reprint Differential expression of aquaporin 7 in adipose tissue of lean and obese high fat consumers
    M Pilar Marrades
    Department of Physiology and Nutrition, University of Navarra, Pamplona, Spain
    Biochem Biophys Res Commun 339:785-9. 2006
    ..The down-regulation of the AQP7 gene could be implicated in the susceptibility to obesity by reducing glycerol release and promoting the accumulation of lipids in the adipose tissue...
  22. doi request reprint Vitamin C modulates the interaction between adipocytes and macrophages
    Diego F García-Díaz
    Department of Nutrition and Food Sciences, Physiology and Toxicology, University of Navarra, Pamplona, Spain
    Mol Nutr Food Res 55:S257-63. 2011
    ..Increased adiposity is related with monocyte infiltration into the adipose tissue that accentuates inflammation. Antioxidant treatments emerge as approaches to counteract this phenomenon...
  23. ncbi request reprint Serum and gene expression levels of leptin and adiponectin in rats susceptible or resistant to diet-induced obesity
    N Pérez-Echarri
    Department of Physiology and Nutrition, University of Navarra, 31008 Pamplona, Spain
    J Physiol Biochem 61:333-42. 2005
    ..However, neither changes in leptin or adiponectin seem to be involved in the adaptive mechanisms that confer resistance to high fat intake...
  24. doi request reprint Role of obesity-associated dysfunctional adipose tissue in cancer: a molecular nutrition approach
    Pedro L Prieto-Hontoria
    Department of Nutrition, Food Science, Physiology and Toxicology, University of Navarra, C Irunlarrea 1, 31008 Pamplona, Spain
    Biochim Biophys Acta 1807:664-78. 2011
    ....
  25. ncbi request reprint Role of adipogenic and thermogenic genes in susceptibility or resistance to develop diet-induced obesity in rats
    N Pérez-Echarri
    Departament of Nutrition, Food Science, Physiology and Toxicology, University of Navarra, 31008 Pamplona, Spain
    J Physiol Biochem 63:317-27. 2007
    ..The compensatory adaptations through the increase in energy expenditure by changes on the expression levels of UCP1 seem not to be enough to avoid the obesity onset in the DIO group...
  26. ncbi request reprint Gene expression changes in rat white adipose tissue after a high-fat diet determined by differential display
    I P Lopez
    Department of Biochemistry and Molecular Biology, University of Navarra, 31080 Pamplona, Navarra, Spain
    Biochem Biophys Res Commun 318:234-9. 2004
    ....
  27. ncbi request reprint Conjugated linoleic acid inhibits glucose metabolism, leptin and adiponectin secretion in primary cultured rat adipocytes
    P Pérez-Matute
    Department of Physiology and Nutrition, University of Navarra, 31008 Pamplona, Spain
    Mol Cell Endocrinol 268:50-8. 2007
    ..Furthermore, the inhibition of leptin and adiponectin production induced by CLA may contribute to insulin resistance observed in CLA-treated animals and humans...
  28. ncbi request reprint Association between obesity and insulin resistance with UCP2-UCP3 gene variants in Spanish children and adolescents
    Maria C Ochoa
    Department of Nutrition and Food Sciences, Physiology and Toxicology, C Irunlarrea s n, University of Navarra, 31080 Pamplona, Spain
    Mol Genet Metab 92:351-8. 2007
    ..Thus, the (-866A; rs659366)-(Ins; 45bp)-(-55C; rs1800849) haplotype may protect against insulin resistance in the obese population group...
  29. doi request reprint Down-regulation in muscle and liver lipogenic genes: EPA ethyl ester treatment in lean and overweight (high-fat-fed) rats
    Nerea Pérez-Echarri
    Department of Nutrition and Food Sciences, Physiology and Toxicology, University of Navarra, Pamplona, Spain
    J Nutr Biochem 20:705-14. 2009
    ..These findings show the ability of EPA ethyl ester treatment to down-regulate some genes involved in fatty acid synthesis without affecting the transcriptional activation of beta-oxidation-related genes...
  30. doi request reprint Association between leptin receptor (LEPR) and brain-derived neurotrophic factor (BDNF) gene variants and obesity: a case-control study
    A Marti
    Department of Nutrition and Food Sciences, Physiology and Toxicology, University of Navarra, 31080 Pamplona, Navarra, Spain
    Nutr Neurosci 12:183-8. 2009
    ..Human and animal studies provide evidence for a relevant role of the leptin receptor (LEPR) and the brain-derived neurotrophic factor (BDNF) genes in energy homeostasis...
  31. ncbi request reprint Down-regulation of heart HFABP and UCP2 gene expression in diet-induced (cafeteria) obese rats
    A Marti
    Dpto de Fisiología y Nutrición, Universidad de Navarra, Pamplona, Spain
    J Physiol Biochem 58:69-74. 2002
    ..The down-regulation of heart HFABP and UCP2 parallels the lower lipid utilization which may account for an enhanced fat deposition. It is plausible that these two genes are regulated by the same family of transcription factors...
  32. ncbi request reprint [Advances in molecular nutrition: nutrigenomics and/or nutrigenetics]
    A Marti
    Dpto de Fisiología y Nutrición, Universidad de Navarra, Pamplona, Navarra, Espana
    Nutr Hosp 20:157-64. 2005
    ..On the one hand, the study of the influence of nutrients on gene expression (nutrigenomics) and, on the other hand, to know the influence of genetic variations in the organism response to nutrients (nutrigenetics)...
  33. ncbi request reprint Vitamin C inhibits leptin secretion and some glucose/lipid metabolic pathways in primary rat adipocytes
    D F García-Diaz
    Department of Nutrition and Food Sciences, Physiology and Toxicology, University of Navarra, Pamplona, Spain
    J Mol Endocrinol 45:33-43. 2010
    ..In summary, this experimental assay describes a specific effect of VC in isolated rat adipocytes on glucose and fat metabolism, and on the secretion/expression of important obesity-related proteins...
  34. doi request reprint Eicosapentaenoic acid stimulates AMP-activated protein kinase and increases visfatin secretion in cultured murine adipocytes
    Silvia Lorente-Cebrián
    Department of Nutrition, Food Science, Physiology and Toxicology, University of Navarra, Pamplona, Spain
    Clin Sci (Lond) 117:243-9. 2009
    ..The results of the present study suggest that the stimulatory action of EPA on visfatin production involves AMPK activation in adipocytes...
  35. ncbi request reprint NF-kappa B-binding activity in an animal diet-induced overweightness model and the impact of subsequent energy restriction
    O Lamas
    Department of Physiology and Nutrition, University of Navarra, 31008 Pamplona, Navarre, Spain
    Biochem Biophys Res Commun 311:533-9. 2003
    ..These results suggest that PPAR gamma 1 may be involved in the altered immune response through changes in the activity of NF-kappa B...
  36. ncbi request reprint ZAG, a lipid mobilizing adipokine, is downregulated in human obesity
    M P Marrades
    Department of Nutrition and Food Science, Physiology and Toxicology, University of Navarra, Pamplona, Spain
    J Physiol Biochem 64:61-6. 2008
    ..Our data suggest that this novel adipokine could play a role in human susceptibility to obesity related disorders and that upregulation of ZAG could be a promising therapeutic target for metabolic syndrome treatment...
  37. ncbi request reprint Effects of eicosapentaenoic acid (EPA) on adiponectin gene expression and secretion in primary cultured rat adipocytes
    S Lorente-Cebrián
    Department of Physiology and Nutrition, University of Navarra, 31008 Pamplona, Spain
    J Physiol Biochem 62:61-9. 2006
    ..Moreover, these results suggest that other mechanisms different from the direct stimulation of adiponectin by the fatty acid are underlying the insulin-sensitizing properties observed after EPA treatment in vivo...
  38. ncbi request reprint Linoleic acid decreases leptin and adiponectin secretion from primary rat adipocytes in the presence of insulin
    P Pérez-Matute
    Department of Physiology and Nutrition, University of Navarra, 31008, Pamplona, Navarra, Spain
    Lipids 42:913-20. 2007
    ....
  39. pmc Cardiotrophin-1: a new player in energy metabolism with potential therapeutic application
    Matilde Bustos
    Division of Hepatology and Gene Therapy, Center for Applied Medical Research CIMA University of Navarra, 31008 Pamplona, Spain
    Aging (Albany NY) 3:698-9. 2011
    ..As a result, new therapeutic options for the treatment of these conditions are clearly warranted. Comment on: Moreno-Aliaga MJ et al. Cell Metab. 2011; 14: 242-253...
  40. ncbi request reprint Lipoic acid prevents body weight gain induced by a high fat diet in rats: effects on intestinal sugar transport
    P L Prieto-Hontoria
    Department of Nutrition, Food Science, Physiology and Toxicology, University of Navarra C Irunlarrea, 1, Pamplona, Spain
    J Physiol Biochem 65:43-50. 2009
    ..Furthemore, the inhibitory action of LA on intestinal sugar transport could explain in part the lower feed efficiency observed in LA-treated animals and therefore, highlighting the beneficial effects of LA on obesity...
  41. ncbi request reprint Differences in short-term metabolic responses to a lipid load in lean (resistant) vs obese (susceptible) young male subjects with habitual high-fat consumption
    M P Marrades
    Department of Physiology and Nutrition, University of Navarra, Pamplona, Spain
    Eur J Clin Nutr 61:166-74. 2007
    ..To determine the role of macronutrients oxidation ability in the postprandial response to a high lipid load in the mechanisms conferring resistance or susceptibility to obesity...
  42. ncbi request reprint Cardiotrophin-1 eliminates hepatic steatosis in obese mice by mechanisms involving AMPK activation
    David Castaño
    Division of Hepatology and Gene Therapy, Center for Applied Medical Research CIMA, University of Navarra, 31008 Pamplona, Spain
    J Hepatol 60:1017-25. 2014
    ..Here we analyzed the changes in hepatic fat stores induced by recombinant CT-1 (rCT-1) and its therapeutic potential in non-alcoholic fatty liver disease (NAFLD)...
  43. ncbi request reprint TV watching modifies obesity risk linked to the 27Glu polymorphism of the ADRB2 gene in girls
    M C Ochoa
    Department of Physiology and Nutrition, University of Navarra, Pamplona, Spain
    Int J Pediatr Obes 1:83-8. 2006
    ..A matched case-control study was conducted in a population of Spanish children and adolescents (5-18 years old), to assess the interaction between the Gln27Glu polymorphism of the ADRB2 and television (TV) watching on obesity risk...
  44. ncbi request reprint A novel mutation Thr162Arg of the melanocortin 4 receptor gene in a Spanish children and adolescent population
    M C Ochoa
    Department of Physiology and Nutrition, University Clinic, University of Navarra, Pamplona Navarra, Spain
    Clin Endocrinol (Oxf) 66:652-8. 2007
    ..In addition, functional assays were performed for a novel MC4R mutation...
  45. ncbi request reprint Gene-gene interaction between PPAR gamma 2 and ADR beta 3 increases obesity risk in children and adolescents
    M C Ochoa
    Department of Physiology and Nutrition, University of Navarra, 31080 Pamplona, Spain
    Int J Obes Relat Metab Disord 28:S37-41. 2004
    ..Our aim was to explore the synergistic contribution of the two polymorphisms: Pro12Ala of the PPAR gamma 2 gene and Trp64Arg of the ADR beta 3 gene to obesity risk in a Spanish children and adolescent population...
  46. ncbi request reprint [Obesity, inflammation and insulin resistance: role of gp 130 receptor ligands]
    B Marcos-Gómez
    Departamento de Ciencias de la Alimentación, Fisiología y Toxicología, Universidad de Navarra, Pamplona, Spain
    An Sist Sanit Navar 31:113-23. 2008
    ..This review analyzes the potential therapeutic role of some of the gp130 ligands in obesity and related diseases...