E J Morcillo

Summary

Affiliation: University of Valencia
Country: Spain

Publications

  1. ncbi request reprint Mucus and MUC in asthma
    Esteban J Morcillo
    Department of Pharmacology, Faculty of Medicine, University of Valencia, and Research Foundation of University General Hospital Consortium, Valencia, Spain
    Curr Opin Pulm Med 12:1-6. 2006
  2. pmc Bronchodilator and anti-inflammatory activities of glaucine: In vitro studies in human airway smooth muscle and polymorphonuclear leukocytes
    J Cortijo
    Departamento de Farmacologia, Facultat de Medicina i Odontologia, Universitat de Valencia, Av Blasco Ibanez 15, E 46010 Valencia, Spain
    Br J Pharmacol 127:1641-51. 1999
  3. ncbi request reprint Effects of taurine on pulmonary responses to antigen in sensitized Brown-Norway rats
    J Cortijo
    Department of Pharmacology, Faculty of Medicine, University of Valencia, Avenida Blasco Ibanez 15, E-46010, Valencia, Spain
    Eur J Pharmacol 431:111-7. 2001
  4. pmc Roflumilast, a phosphodiesterase 4 inhibitor, alleviates bleomycin-induced lung injury
    J Cortijo
    Department of Pharmacology, University of Valencia, Spain
    Br J Pharmacol 156:534-44. 2009
  5. doi request reprint Taurine chloramine inhibits functional responses of human eosinophils in vitro
    M Martinez-Losa
    Departamento de Farmacologia, Facultad de Medicina, Universidad de Valencia, Valencia, Spain
    Clin Exp Allergy 39:537-46. 2009
  6. doi request reprint Bosentan inhibits cigarette smoke-induced endothelin receptor expression in pulmonary arteries
    J Milara
    Clinic Research Unit, University General Hospital Consortium, Valencia, Spain
    Eur Respir J 39:927-38. 2012
  7. ncbi request reprint Modulatory effects of N-acetyl-L-cysteine on human eosinophil apoptosis
    M Martinez-Losa
    Department of Pharmacology, Faculty of Medicine, Avenida Blasco Ibanez 15, E 46010 Valencia, Spain
    Eur Respir J 30:436-42. 2007
  8. doi request reprint Oxidative stress-induced glucocorticoid resistance is prevented by dual PDE3/PDE4 inhibition in human alveolar macrophages
    J Milara
    Research Unit, University General Hospital Consortium, Valencia, Spain
    Clin Exp Allergy 41:535-46. 2011
  9. ncbi request reprint Inhibitory effects of N-acetylcysteine on the functional responses of human eosinophils in vitro
    M Martinez-Losa
    Department of Pharmacology, University of Valencia, Valencia, Spain
    Clin Exp Allergy 37:714-22. 2007
  10. ncbi request reprint Responses to histamine and selective H2-receptor agonists in lung parenchymal strips from normal and sensitized guinea-pigs
    J Cortijo
    Departamento de Farmacologia y Farmacotecnia, Universitat de Valencia, Spain
    Agents Actions 28:45-52. 1989

Collaborators

  • J Cortijo
  • F Santangelo
  • J L Ortiz
  • M J Sanz
  • A Hatzelmann
  • Javier Milara
  • J V Castell
  • A Navarro
  • J Martinez
  • A C Issekutz
  • Manuel Mata
  • P Lopez
  • Ian P Hall
  • Samantha E Peel
  • M Martinez-Losa
  • Teresa Mateo
  • Yafa Naim Abu Nabah
  • Rossana Estellés
  • G Juan
  • Peter J Jose
  • S Blesa
  • Mercedes Losada
  • Miguel Cerda-Nicolas
  • Miguel A Merino-Ramirez
  • Chantal Company
  • C Ballester
  • M Ramon
  • J Barrio
  • Amparo Buenestado
  • Henry Sarau
  • Jana Suchankova
  • Magdalena Martinez-Losa
  • Maria Dolores Ivorra
  • Lara Milian
  • María Amparo Blázquez
  • L Piqueras
  • Laura Piqueras
  • E Garcia-Granero
  • S Lledo
  • Begoña Bedrina
  • Concha Lopez-Gines
  • J E O'Connor
  • Stephen Poole
  • Jose Miguel Cerda-Nicolas
  • Gustavo Juan
  • Mercedes Ramón
  • B Sarria
  • C Perez
  • May Abu Taha
  • Amanda E I Proudfoot
  • R Navarro
  • R Guijarro
  • P Blasco
  • Rolf A K Stahl
  • Ezequiel Martí-Bonmatí
  • T Lloret
  • Yafa Naim-Abu-Nabah
  • John Zagorski
  • José Enrique O'Connor
  • J Suchankova
  • Javier López-Martín
  • Edet M Anam
  • J M Estrela
  • A Serrano
  • D Closa
  • E Seda

Detail Information

Publications37

  1. ncbi request reprint Mucus and MUC in asthma
    Esteban J Morcillo
    Department of Pharmacology, Faculty of Medicine, University of Valencia, and Research Foundation of University General Hospital Consortium, Valencia, Spain
    Curr Opin Pulm Med 12:1-6. 2006
    ..However, mucus plugging contributes to airflow limitation and airway hyperresponsiveness, and to morbidity and mortality in asthma. We review recent contributions to this field and therapeutic avenues to control mucus hypersecretion...
  2. pmc Bronchodilator and anti-inflammatory activities of glaucine: In vitro studies in human airway smooth muscle and polymorphonuclear leukocytes
    J Cortijo
    Departamento de Farmacologia, Facultat de Medicina i Odontologia, Universitat de Valencia, Av Blasco Ibanez 15, E 46010 Valencia, Spain
    Br J Pharmacol 127:1641-51. 1999
    ..The very low PDE4/binding site ratio found for glaucine makes this compound attractive for further structure-activity studies...
  3. ncbi request reprint Effects of taurine on pulmonary responses to antigen in sensitized Brown-Norway rats
    J Cortijo
    Department of Pharmacology, Faculty of Medicine, University of Valencia, Avenida Blasco Ibanez 15, E-46010, Valencia, Spain
    Eur J Pharmacol 431:111-7. 2001
    ..In conclusion, oral taurine showed beneficial effects in an in vivo model of experimental asthma, which confirm and extend the previous positive findings obtained in other models of lung injury...
  4. pmc Roflumilast, a phosphodiesterase 4 inhibitor, alleviates bleomycin-induced lung injury
    J Cortijo
    Department of Pharmacology, University of Valencia, Spain
    Br J Pharmacol 156:534-44. 2009
    ..The effects of a phosphodiesterase 4 (PDE4) inhibitor, roflumilast, on bleomycin-induced lung injury were explored in 'preventive' and 'therapeutic' protocols and compared with glucocorticoids...
  5. doi request reprint Taurine chloramine inhibits functional responses of human eosinophils in vitro
    M Martinez-Losa
    Departamento de Farmacologia, Facultad de Medicina, Universidad de Valencia, Valencia, Spain
    Clin Exp Allergy 39:537-46. 2009
    ..Eosinophils are prominent effectors of allergic inflammation. Taurine-chloramine (TauCl), a derivative of the amino acid taurine, shows antioxidant properties in different cell systems but its effects on eosinophils have not been reported...
  6. doi request reprint Bosentan inhibits cigarette smoke-induced endothelin receptor expression in pulmonary arteries
    J Milara
    Clinic Research Unit, University General Hospital Consortium, Valencia, Spain
    Eur Respir J 39:927-38. 2012
    ..These data may be of potential value to explain therapeutic effects of bosentan in some forms of disproportionate pulmonary hypertension in COPD patients...
  7. ncbi request reprint Modulatory effects of N-acetyl-L-cysteine on human eosinophil apoptosis
    M Martinez-Losa
    Department of Pharmacology, Faculty of Medicine, Avenida Blasco Ibanez 15, E 46010 Valencia, Spain
    Eur Respir J 30:436-42. 2007
    ..In conclusion, N-acetylcysteine modulates eosinophil apoptosis by inhibiting constitutive apoptosis but reversing the survival effect produced by inflammatory cytokines in human eosinophils...
  8. doi request reprint Oxidative stress-induced glucocorticoid resistance is prevented by dual PDE3/PDE4 inhibition in human alveolar macrophages
    J Milara
    Research Unit, University General Hospital Consortium, Valencia, Spain
    Clin Exp Allergy 41:535-46. 2011
    ..Oxidative stress is present in airway diseases such as severe asthma or Chronic Obstructive Pulmonary Disease and contributes to the low response to glucocorticoids through the down-regulation of histone deacetylase (HDAC) activity...
  9. ncbi request reprint Inhibitory effects of N-acetylcysteine on the functional responses of human eosinophils in vitro
    M Martinez-Losa
    Department of Pharmacology, University of Valencia, Valencia, Spain
    Clin Exp Allergy 37:714-22. 2007
    ..Oxidative stress appears to be relevant in the pathogenesis of inflammation in allergic diseases like bronchial asthma. Eosinophils are oxidant-sensitive cells considered as key effectors in allergic inflammation...
  10. ncbi request reprint Responses to histamine and selective H2-receptor agonists in lung parenchymal strips from normal and sensitized guinea-pigs
    J Cortijo
    Departamento de Farmacologia y Farmacotecnia, Universitat de Valencia, Spain
    Agents Actions 28:45-52. 1989
    ..Hyperreactivity to histamine is probably due to differences between normal and sensitized tissues with respect to Ca2+ entry and/or intracellular Ca2+ release in response to H1-receptor activation...
  11. pmc Phosphodiesterase 4 inhibition decreases MUC5AC expression induced by epidermal growth factor in human airway epithelial cells
    M Mata
    Department of Pharmacology, Faculty of Medicine, University of Valencia, Spain
    Thorax 60:144-52. 2005
    ..Recent clinical trials indicate that phosphodiesterase type 4 (PDE4) inhibitors may have therapeutic value for COPD and asthma. However, their direct effects on mucin expression have been scarcely investigated...
  12. ncbi request reprint Oral N-acetylcysteine attenuates the rat pulmonary inflammatory response to antigen
    S Blesa
    Dept of Pharmacology, Faculty of Medicine, University of Valencia, Valencia, Spain
    Eur Respir J 21:394-400. 2003
    ..These results indicate that oral N-acetylcysteine exerts an antioxidant protective effect and attenuates pulmonary inflammation in experimental asthma...
  13. pmc Cigarette smoke exposure up-regulates endothelin receptor B in human pulmonary artery endothelial cells: molecular and functional consequences
    J Milara
    Research Unit, University General Hospital Consortium, Valencia, Spain
    Br J Pharmacol 161:1599-615. 2010
    ..We studied the effect of cigarette smoke extract (CSE) on endothelin receptor B (ET(B) ) expression in human pulmonary artery endothelial cells (HPAECs) and its role in endothelial dysfunction...
  14. ncbi request reprint Oral N-acetylcysteine reduces bleomycin-induced lung damage and mucin Muc5ac expression in rats
    M Mata
    Dept of Pharmacology, Faculty of Medicine, University of Valencia, Valencia, Spain
    Eur Respir J 22:900-5. 2003
    ..These results indicate that bleomycin increases the number of airway secretory cells and their mucin production, and that oral N-acetylcysteine improved pulmonary lesions and reduced the mucus hypersecretion in the bleomycin rat model...
  15. doi request reprint Nickel induces intracellular calcium mobilization and pathophysiological responses in human cultured airway epithelial cells
    Julio Cortijo
    Department of Pharmacology, Faculty of Medicine, University of Valencia, Valencia, Spain
    Chem Biol Interact 183:25-33. 2010
    ....
  16. ncbi request reprint In vitro tracheal hyperresponsiveness to muscarinic receptor stimulation by carbachol in a rat model of bleomycin-induced pulmonary fibrosis
    J Barrio
    Department of Pharmacology, Faculty of Medicine, University of Valencia, Av Blasco Ibanez 15, E 46010 Valencia, Spain
    Auton Autacoid Pharmacol 26:327-33. 2006
    ..This in vitro cholinergic hyperresponsiveness may be related to the augmented levels of inflammatory cytokines in bleomycin-exposed rats...
  17. pmc The effects of phorbol 12,13-diacetate on responses of guinea-pig isolated trachea to methylxanthines, isoprenaline and ryanodine
    J Cortijo
    Department of Pharmacology, Faculty of Medicine, University of Valencia, Spain
    Br J Pharmacol 111:769-76. 1994
    ..The evidence suggests, instead, that PDA facilitates methylxanthine- or ryanodine-induced release of Ca2+ from the intracellular store...
  18. ncbi request reprint beta-Adrenoceptor stimulation up-regulates phosphodiesterase 4 activity and reduces prostaglandin E2-inhibitory effects in human neutrophils
    J L Ortiz
    Departament de Farmacologia, Facultat de Medicina i Odontologia, Universitat de Valencia, Spain
    Naunyn Schmiedebergs Arch Pharmacol 361:410-7. 2000
    ..Functionally, up-regulation of phosphodiesterase 4 reduced the inhibition by prostaglandin E2 of zymosan-induced superoxide generation...
  19. pmc Roflumilast inhibits leukocyte-endothelial cell interactions, expression of adhesion molecules and microvascular permeability
    M J Sanz
    Department of Pharmacology, University of Valencia, Valencia, Spain
    Br J Pharmacol 152:481-92. 2007
    ..The present study addressed the effects of the investigational PDE4 inhibitor roflumilast on leukocyte-endothelial cell interactions and endothelial permeability in vivo and in vitro...
  20. doi request reprint Aclidinium inhibits cholinergic and tobacco smoke-induced MUC5AC in human airways
    J Cortijo
    Clinical PharmacologyFaculty of Medicine of the University of Valencia, Research Foundation of University Clinic Hospital, Valencia, Spain
    Eur Respir J 37:244-54. 2011
    ..This effect may contribute to the clinical efficacy of aclidinium in mucus hypersecretory diseases including COPD...
  21. ncbi request reprint Relaxation of the isolated human internal anal sphincter by sildenafil
    C Ballester
    Department of Surgery, University of Valencia, Valencia, Spain
    Br J Surg 94:894-902. 2007
    ..Hypertonicity of the internal anal sphincter (IAS) appears to be involved in the pathogenesis of anal fissure. The relaxant effects of sildenafil, a selective phosphodiesterase 5 (PDE5) inhibitor, on isolated human IAS were investigated...
  22. ncbi request reprint Biotransformation in vitro of the 22R and 22S epimers of budesonide by human liver, bronchus, colonic mucosa and skin
    J Cortijo
    Department of Pharmacology, University of Valencia, Valencia, Spain
    Fundam Clin Pharmacol 15:47-54. 2001
    ..These findings extend those of other studies, and confirm that the high therapeutic ratio of budesonide is due to negligible local biotransformation combined with high level of liver metabolism for locally absorbed budesonide...
  23. ncbi request reprint Effectiveness of oral N -acetylcysteine in a rat experimental model of asthma
    S Blesa
    Department of Pharmacology, Faculty of Medicine, University of Valencia, Av Blasco Ibanez 15, E 46010 Valencia, Spain
    Pharmacol Res 45:135-40. 2002
    ..In conclusion, oral N -acetylcysteine showed beneficial effects in an in vivo model of experimental asthma, which confirm and extend the previous positive findings obtained in other models of lung injury...
  24. ncbi request reprint Directly observed treatment for tuberculosis in pharmacies compared with self-administered therapy in Spain
    G Juan
    Department of Medicine, Faculty of Medicine, University of Valencia, Spain
    Int J Tuberc Lung Dis 10:215-21. 2006
    ..To compare directly observed treatment (DOT) of tuberculosis through pharmacy offices with self-administered treatment (SAT) in patients at risk for non-adherence...
  25. ncbi request reprint Angiotensin II-induced mononuclear leukocyte interactions with arteriolar and venular endothelium are mediated by the release of different CC chemokines
    Teresa Mateo
    Department of Pharmacology, Faculty of Medicine, University of Valencia, Avenida Blasco Ibanez 15, E 46010 Valencia, Spain
    J Immunol 176:5577-86. 2006
    ..Thus, Ang-II may be a key molecule in the initial attachment of mononuclear cells to the arterial endothelium in cardiovascular disease states where this event is a characteristic feature...
  26. pmc Effect of two phenanthrene alkaloids on angiotensin II-induced leukocyte-endothelial cell interactions in vivo
    Rossana Estellés
    Department of Pharmacology, Faculty of Medicine, University of Valencia, Avda Blasco Ibanez, 17, E 46010 Valencia, Spain
    Br J Pharmacol 140:1057-67. 2003
    ..Thus, they have potential therapeutic interest for the control of leukocyte recruitment that occurs in cardiovascular disease states in which Ang-II is involved...
  27. pmc Rolipram inhibits leukocyte-endothelial cell interactions in vivo through P- and E-selectin downregulation
    Maria Jesus Sanz
    Department of Pharmacology, Faculty of Medicine, University of Valencia, Spain
    Br J Pharmacol 135:1872-81. 2002
    ..The effects observed are mediated through endothelial P- and E-selectin downregulation. Therefore, selective PDE-4 inhibitors may be useful in the control of different inflammatory disorders...
  28. ncbi request reprint CXCR2 blockade impairs angiotensin II-induced CC chemokine synthesis and mononuclear leukocyte infiltration
    Yafa Naim Abu Nabah
    Departments of Pharmacology, Faculty of Medicine, University Clinic Hospital, University of Valencia, Spain
    Arterioscler Thromb Vasc Biol 27:2370-6. 2007
    ..Angiotensin II (Ang-II) and mononuclear leukocytes are involved in atherosclerosis. This study reports the inhibition of Ang-II-induced mononuclear cell recruitment by CXCR2 antagonism and the mechanisms involved...
  29. ncbi request reprint A critical role for TNFalpha in the selective attachment of mononuclear leukocytes to angiotensin-II-stimulated arterioles
    Teresa Mateo
    Department of Pharmacology, Faculty of Medicine, University of Valencia, Spain
    Blood 110:1895-902. 2007
    ..Therefore, neutralization of TNFalpha activity may help to prevent mononuclear cell infiltration and the progression of the atherogenic process...
  30. ncbi request reprint Angiotensin II induces neutrophil accumulation in vivo through generation and release of CXC chemokines
    Yafa Naim Abu Nabah
    Department of Pharmacology, Faculty of Medicine, University of Valencia, Valencia, Spain
    Circulation 110:3581-6. 2004
    ..Ang II can be generated intravascularly by the renin-angiotensin system or extravascularly by mast cell chymase. In this study, we characterized the ability of Ang II to induce neutrophil accumulation...
  31. ncbi request reprint Diaphragmatic paralysis following minor cervical trauma
    Miguel A Merino-Ramirez
    Clinical Neurophysiology Service, La Ribera Hospital, Alzira, Valencia, Spain
    Muscle Nerve 36:267-70. 2007
    ..In spite of only partial electrophysiological recovery of the nerve, both patients were asymptomatic 1 year later...
  32. ncbi request reprint Olive oil-based lipid emulsion's neutral effects on neutrophil functions and leukocyte-endothelial cell interactions
    Amparo Buenestado
    Department of Pharmacology and Central Research Unit, Faculty of Medicine, University of Valencia, Valencia, Spain
    JPEN J Parenter Enteral Nutr 30:286-96. 2006
    ....
  33. ncbi request reprint Effect of boldine, secoboldine, and boldine methine on angiotensin II-induced neutrophil recruitment in vivo
    Rossana Estellés
    Facultad de Medicina, Universidad de Valencia, Av Blasco Ibanez, 15, 46010 Valencia, Spain
    J Leukoc Biol 78:696-704. 2005
    ..Thus, it may have potential therapeutic interest for the control of neutrophil recruitment that occurs in inflammation associated with elevated levels of Ang-II...
  34. ncbi request reprint PDE4 inhibitors as new anti-inflammatory drugs: effects on cell trafficking and cell adhesion molecules expression
    Maria Jesus Sanz
    Department of Pharmacology, Faculty of Medicine, University of Valencia, Avenida Blasco Ibanez 15, E 46010 Valencia, Spain
    Pharmacol Ther 106:269-97. 2005
    ..These new drugs may also offer opportunities for treatment of other inflammatory diseases...
  35. pmc Erythromycin exerts in vivo anti-inflammatory activity downregulating cell adhesion molecule expression
    Maria Jesus Sanz
    Department of Pharmacology, Faculty of Medicine, University of Valencia, Avda Blasco Ibanez 15, Valencia 46010, Spain
    Br J Pharmacol 144:190-201. 2005
    ..7. In conclusion, erythromycin inhibits leukocyte recruitment in the lung and this effect appears mediated through downregulation of CAM expression. Therefore, macrolides may be useful in the control of neutrophilic pulmonary diseases...
  36. ncbi request reprint Effects of bemiparin on airway responses to antigen in sensitized Brown-Norway rats
    Jana Suchankova
    Department of Pharmacology, University of Valencia, Avenida Blasco Ibanez 15, E 46010 Valencia, Spain
    Eur J Pharmacol 507:261-71. 2005
    ..In conclusion, bemiparin showed beneficial effects in experimental asthma, probably unrelated to its anticoagulant activity, which extends the previous positive findings obtained with other heparins...
  37. pmc A small molecule, orally active, alpha4beta1/alpha4beta7 dual antagonist reduces leukocyte infiltration and airway hyper-responsiveness in an experimental model of allergic asthma in Brown Norway rats
    Julio Cortijo
    Department of Pharmacology, Faculty of Medicine, University of Valencia, Avda Blasco Ibanez, 15, 46010 Valencia, Spain
    Br J Pharmacol 147:661-70. 2006
    ....