You are here: Scientific Experts > Spain > University of Cantabria > Moncalian > Gabriel Moncalian
Affiliation: University of Cantabria
Santín O, Moncalian G. Loading of malonyl-CoA onto tandem acyl carrier protein domains of polyunsaturated fatty acid synthases. J Biol Chem. 2018;293:12491-12501 pubmed publisher
..These results, together with the structural organization predicted for PfaA, suggest that this protein plays a key role at early stages of the anaerobic pathway of PUFA synthesis. ..
Giner Robles L, Lázaro B, de la Cruz F, Moncalian G. fabH deletion increases DHA production in Escherichia coli expressing Pfa genes. Microb Cell Fact. 2018;17:88 pubmed publisher
..DHA-producing E. coli strain that carries a fabH gene deletion boosts DHA production by tuning down the competing canonical biosynthesis pathway. Our approach can be used for optimization of DHA production in different organisms. ..
Wan X, Peng Y, Zhou X, Gong Y, Huang F, MoncaliÃ¡n G. Effect of cerulenin on fatty acid composition and gene expression pattern of DHA-producing strain Colwellia psychrerythraea strain 34H. Microb Cell Fact. 2016;15:30 pubmed publisher
..In addition, inhibition of FabB protein by cerulenin may lead to the accumulation of malonyl-CoA, which is the substrate for DHA formation. ..