Affiliation: University of Barcelona
- Randomised placebo-controlled trial of iron supplementation and malaria chemoprophylaxis for prevention of severe anaemia and malaria in Tanzanian infantsC Menendez
Unidad de Epidemiologia y Bioestadistica, Hospital Clinic, Barcelona, Spain
Lancet 350:844-50. 1997..We undertook a randomised comparison of different strategies for control of anaemia and malaria in infants, including an assessment of the effect of iron supplementation on malaria susceptibility...
- The effects of short-term iron supplementation on iron status in infants in malaria-endemic areasClara Menendez
Center for International Health y Departamento de Bioquimica Clínica Institut d Investigacions Biome diques August Pi i Sunyer Hospital Clinic, Villarroeal 170, E 08036, Barcelona, Spain
Am J Trop Med Hyg 71:434-40. 2004..7% versus 37.3% at 12 months of age). We concluded that iron supplementation between the ages of 2-6 months improves iron status at least up to 12 months of age. Malaria infection does not contribute to iron deficiency...
- Prevalence and mother-to-infant transmission of hepatitis viruses B, C, and E in Southern TanzaniaC Menendez
Unidad de Epidemiologia y Bioestadistica, Institut d Investigacions Biomedicas August Pi i Sunyer IDIBAPS, Hospital Clinic, Barcelona, Spain
J Med Virol 58:215-20. 1999..The results of this study show for the first time in Africa that mother-to-infant transmission does not play a significant role in the acquisition of HCV infection...
- Intermittent treatment for malaria and anaemia control at time of routine vaccinations in Tanzanian infants: a randomised, placebo-controlled trialD Schellenberg
Unidad de Epidemiologia, Hospital Clinic, , Villarroel 170, 08036, Barcelona, Spain
Lancet 357:1471-7. 2001..Data are urgently needed to assess the potential cost-effectiveness of intermittent treatment in areas with different patterns of malaria endemicity...
- Cost-effectiveness of iron supplementation and malaria chemoprophylaxis in the prevention of anaemia and malaria among Tanzanian infantsM Alonzo González
Epidemiology and Biostatistics Unit, Hospital Clinic, Barcelona, Spain
Bull World Health Organ 78:97-107. 2000..This economic analysis supports the inclusion of both malaria chemoprophylaxis and iron supplementation delivered through EPI as part of the control strategies for these major killers of infants in parts of sub-Saharan Africa...
- Effect of malaria on soluble transferrin receptor levels in Tanzanian infantsC Menendez
, , Hospital Clinic, Barcelona, Spain
Am J Trop Med Hyg 65:138-42. 2001..We conclude that the measurement of sTfR levels does not have a role in the diagnosis of iron deficiency anemia in young children exposed to malaria infection...
- Mother-to-child transmission of HIV-1: association with malaria prevention, anaemia and placental malariaD Naniche
Barcelona Center for International Health Research CRESIB, Hospital Clinic, Universitat de Barcelona, Barcelona, Spain
HIV Med 9:757-64. 2008..Prevention of malaria in pregnancy could thus potentially affect MTCT of HIV. We studied the impact of intermittent preventive treatment during pregnancy (IPTp) on HIV-1 MTCT in southern Mozambique...
- The impact of placental malaria on gestational age and birth weightC Menendez
Unidad de Epidemiologia y Bioestadistica, Hospital Clinic, E 08036, Barcelona, Spain
J Infect Dis 181:1740-5. 2000..This study also shows that placental malaria causes prematurity even in high-transmission areas. The impact of maternal malaria on infant mortality may be greater than was thought previously...
- The incidence of clinical malaria detected by active case detection in children in Ifakara, southern TanzaniaD M Schellenberg
Centro de Salud International, Institut d Investigacions Biomedicas August Pi i Sunyer IDIBAPS, Hospital Clinic, Villarroel 170, 08036 Barcelona, Spain
Trans R Soc Trop Med Hyg 97:647-54. 2003....
- Malaria-related anaemiaC Menendez
Unidad de Epidemiologia y Bioestadisica, Hospital Clinic, Barcelona, Spain
Parasitol Today 16:469-76. 2000..In this review, Clara Menendez, Alan Fleming and Pedro Alonso focus on recent advances in our knowledge of the pathophysiology, epidemiology, management and prevention of anaemia from falciparum malaria...
- Placental malaria is associated with cell-mediated inflammatory responses with selective absence of natural killer cellsJ Ordi
Department of Pathology, Institut d Investigacions Biomèdiques August Pi i Sunyer IDIBAPS Hospital Clínic, Facultat de Medicina, Universitat de Barcelona, 08036 Barcelona, Spain
J Infect Dis 183:1100-7. 2001..These results indicate that placental malaria does not appear to be associated with cell-mediated immunosuppression. The role of the absence of NK cells in increased susceptibility to malaria needs to be further elucidated...
- Massive Plasmodium falciparum visceral sequestration: a cause of maternal death in AfricaP Castillo
Barcelona Centre for International Health Research CRESIB, Department of Pathology, Hospital Clinic, Universitat de Barcelona, Barcelona, Spain
Clin Microbiol Infect 19:1035-41. 2013..The PfIE sequestered in cerebral capillaries and the placenta coexist in these fatal cases. ..
- High HIV prevalence in a southern semi-rural area of Mozambique: a community-based surveyR Gonzalez
Barcelona Centre for International Heath Research CRESIB, Hospital Clinic, University of Barcelona, Barcelona, Spain
HIV Med 13:581-8. 2012..Southern African countries have borne the brunt of the HIV/AIDS pandemic. Monitoring epidemiological dynamics is critical to identify the populations at greatest risk of infection and to guide control strategies...
- The changing epidemiology of malaria in Ifakara Town, southern TanzaniaDavid Schellenberg
Centre for International Health, Institut de Investigaciones Biomedicas August Pi I Sunyer, Barcelona, Spain
Trop Med Int Health 9:68-76. 2004..Even in low/moderate malaria transmission settings, where older children suffer most malaria episodes, targeting effective malaria control at infants may produce important reductions in infant mortality caused by malaria...
- The epidemiology of malaria in adults in a rural area of southern MozambiqueAlfredo Mayor
Center for International Health, Hospital Clinic, IDIBAPS, University of Barcelona, Barcelona, Spain
Malar J 6:3. 2007..The present study was undertaken to investigate the clinical, parasitological and haematological status of adults exposed to malaria, and to characterize parasites in these individuals who progressively acquire protective immunity...
- Age interactions in the development of naturally acquired immunity to Plasmodium falciparum and its clinical presentationJohn J Aponte
Barcelona Centre for International Health Research, Hospital Clinic IDIBAPS, Universitat de Barcelona, Barcelona, Spain
PLoS Med 4:e242. 2007..We investigated the role of age in disease incidence and the effects of chemoprophylaxis on clinical immunity development to Plasmodium falciparum during a randomised controlled trial...
- Malaria infection does not appear to modify the risk of bronchiolitis early in lifeClara Menendez
Unidad de Epidemiologia y Bioestadistica, Institut d Investigaciones Mediques August Pi i Sunyer, Hospital Clinic, Barcelona, Spain
Pediatr Infect Dis J 21:249-54. 2002..Information on the role of parasites in this context is limited. Bronchiolitis in infancy has been linked with asthmatic symptoms later in childhood, although the underlying cause of this association is unknown...
- A randomized comparison of two anemia treatment regimens in Tanzanian childrenDavid Schellenberg
Centre for International Health, Institut d Investigacions Biomedicas August Pi i Sunyer, Hospital Clinic, Villarroel 170, Barcelona 08036, Spain
Am J Trop Med Hyg 71:428-33. 2004..06). Compliance was satisfactory in only 39% (82 of 209) of the children in the first week of treatment. Extending the duration of therapy and improving compliance may have health benefits for anemic children in malaria-endemic settings...
- Malaria in pregnancy in rural Mozambique: the role of parity, submicroscopic and multiple Plasmodium falciparum infectionsFrancisco Saute
Centro de Investigação em Saúde da Manhiça, Instituto Nacional de Saude, Maputo, Mozambique
Trop Med Int Health 7:19-28. 2002..It also tried to assess the frequency and effect on anaemia of submicroscopic and multiple falciparum infections...
- Treatment and prevention of malaria in pregnancy and newbornOriol Coll
Department of Maternal Fetal Medicine, Institut Clinic de Ginecologia, Obstetricia i Neonatologia, Institut d Investigacions Biomediques August Pi i Sunyer, Hospital Clinic de Barcelona, Barcelona, Spain
J Perinat Med 36:15-29. 2008..In this paper, we review the pathology, diagnosis, and current recommendations for treatment and prevention of malaria in the pregnant woman and her infant...
- Varying efficacy of intermittent preventive treatment for malaria in infants in two similar trials: public health implicationsClara Menendez
Barcelona Center for International Health Research CRESIB, Hospital Clinic, Institut d Investigacions Biomedicas August Pi i Sunyer IDIBAPS, Universitat de Barcelona, Spain
Malar J 6:132. 2007..Understanding the reasons for the discrepant results will help to elucidate the action mechanism of this intervention, which is essential for rational policy formulation...
- Antimalarial drugs in pregnancy: a reviewFrancois Nosten
Shoklo Malaria Research Unit, 63110 Mae Sot, Thailand
Curr Drug Saf 1:1-15. 2006..For these reasons there is an urgent need to assess the safety and efficacy of antimalarial treatments in pregnancy, including artemisinin based combination therapies...
- Seasonal variations in maternal mortality in Maputo, Mozambique: the role of malariaCleofe Romagosa
Department of Pathology, Hospital Clinic, University of Barcelona Institut d Investigacions Biomèdiques August Pi i Sunyer, Barcelona, Spain
Trop Med Int Health 12:62-7. 2007..To evaluate the impact of malaria on maternal death through the analysis of the seasonal variations of crude and malaria-specific maternal mortality rates...
- Community response to intermittent preventive treatment delivered to infants (IPTi) through the EPI system in Manhiça, MozambiqueRobert Pool
London School of Hygiene and Tropical Medicine, London, UK, and Center for International Health, Hospital Clinic, IDIBAPS, Barcelona, Spain
Trop Med Int Health 11:1670-8. 2006..In particular, whether the introduction of IPTi negatively affects community attitudes to, or use of, EPI; or, conversely, whether and if so how, the concurrent delivery of IPTi and immunization influences perceptions of IPTi...
- Treatment and prevention of malaria in pregnancy: opportunities and challengesStephen J Rogerson
University of Melbourne, Department of Medicine, Royal Melbourne Hospital, Australia
Expert Rev Anti Infect Ther 4:687-702. 2006..Prevention of pregnancy malaria by vaccination may also become possible, but targets must be closely defined, and strategies developed to test candidates against meaningful end points...
- Intermittent preventive treatment for malaria control administered at the time of routine vaccinations in Mozambican infants: a randomized, placebo-controlled trialEusebio Macete
Manhiça Health Research Center, Manhiça, Mozambique
J Infect Dis 194:276-85. 2006..There is an urgent need to deploy and develop new control tools that will reduce the intolerable burden of malaria. Intermittent preventive treatment in infants (IPTi) has the potential to become an effective tool for malaria control...
- The IPTi Consortium: research for policy and actionDavid Schellenberg
Department of Infectious Diseases, London School of Hygiene and Tropical Medicine, University of London, Keppel Street, London WC1E 7HT, UK
Trends Parasitol 22:296-300. 2006..This review summarizes the available information on IPTi and presents the consortium's approach to determining whether IPTi might be a valuable additional strategy in programs to control malaria...
- Duration of protection with RTS,S/AS02A malaria vaccine in prevention of Plasmodium falciparum disease in Mozambican children: single-blind extended follow-up of a randomised controlled trialPedro L Alonso
Centre de Salut Internacional, Hospital Clinic Institut d Investigacions Biomediques August Pi i Sunyer, Universitat de Barcelona, Villarroel 170, 08036 Barcelona, Spain
Lancet 366:2012-8. 2005..An important remaining issue is the durability of protection against clinical disease in these children...
- Risk factors for presentation to hospital with severe anaemia in Tanzanian children: a case-control studyElizeus Kahigwa
Ifakara Health Research and Development Centre, Ifakara, Tanzania
Trop Med Int Health 7:823-30. 2002..The concentration of anaemia in infants and problems of access to health services and adequate case management underline the need for targeted preventive strategies for anaemia control...
- The safety and efficacy of sulfadoxine-pyrimethamine, amodiaquine, and their combination in the treatment of uncomplicated Plasmodium falciparum malariaDavid Schellenberg
Unidad de Epidemiologia, Hospital Clinic, Barcelona, Spain
Am J Trop Med Hyg 67:17-23. 2002..6% vs. SP 29.9%; P = 0.001). The level of R1 resistance to SP may herald a rapid decline in its efficacy as SP drug pressure increases. Coadministration of AQ+SP may delay this...
- Polarisation microscopy increases the sensitivity of hemozoin and Plasmodium detection in the histological assessment of placental malariaCleofe Romagosa
Department of Anatomical Pathology, Facultat de Medicina, Institut d Investigacions Biomèdiques August Pi i Sunyer Hospital Clínic, Universitat de Barcelona, Villarroel 170, 08036 Barcelona, Spain
Acta Trop 90:277-84. 2004..This method can be useful to investigators working in the malaria field...
- Intermittent preventive antimalarial treatment for Tanzanian infants: follow-up to age 2 years of a randomised, placebo-controlled trialDavid Schellenberg
Centre for International Health, Institut d Investigacions Biomedicas August Pi i Sunyer IDIBAPS, Hospital Clinic, Barcelona, Spain
Lancet 365:1481-3. 2005....