Guillermo Mazzolini

Summary

Affiliation: University of Navarra
Country: Spain

Publications

  1. ncbi Intratumoral injection of dendritic cells engineered to secrete interleukin-12 by recombinant adenovirus in patients with metastatic gastrointestinal carcinomas
    Guillermo Mazzolini
    Division of Hepatology and Gene Therapy, Department of Radiology, Clinica Universitaria School of Medicine, University of Navarra, C Irunlarrea, S N, 31008 Pamplona, Spain
    J Clin Oncol 23:999-1010. 2005
  2. ncbi Gene therapy of cancer with interleukin-12
    Guillermo Mazzolini
    Division of Hepatology and Gene Therapy, Department of Medicine, Centro de Investigación Médica Aplicada FIMA, School of Medicine and Clinica Universitaria, University of Navarra, Pamplona, Spain
    Curr Pharm Des 9:1981-91. 2003
  3. ncbi Anti-ICAM-2 monoclonal antibody synergizes with intratumor gene transfer of interleukin-12 inhibiting activation-induced T-cell death
    Ignacio Melero
    Centro de Investigación Médica Aplicada CIMA, Facultad de Medicina, Gene Therapy Unit, Universidad de Navarra, 31008 Pamplona, Spain
    Clin Cancer Res 9:3546-54. 2003
  4. ncbi Dendritic cells delivered inside human carcinomas are sequestered by interleukin-8
    Esperanza Feijoo
    Division of Hepatology and Gene Therapy, Clinica Universitaria School of Medicine, Foundation for Applied Medical Research, Universidad de Navarra, Pamplona, Spain
    Int J Cancer 116:275-81. 2005
  5. ncbi Potentiation of therapeutic immune responses against malignancies with monoclonal antibodies
    Oihana Murillo
    Centro de Investigación Médica Aplicada and Clinica Universitaria, Universidad de Navarra, Pamplona, Spain
    Clin Cancer Res 9:5454-64. 2003
  6. ncbi Positron emission tomography imaging of adenoviral-mediated transgene expression in liver cancer patients
    Ivan Penuelas
    Department of Nuclear Medicine, Clinica Universitaria de Navarro, Pamplona, Spain
    Gastroenterology 128:1787-95. 2005
  7. ncbi An anti-ICAM-2 (CD102) monoclonal antibody induces immune-mediated regressions of transplanted ICAM-2-negative colon carcinomas
    Ignacio Melero
    Gene Therapy Unit, Department of Medicine, University of Navarra School of Medicine, C Irunlarrea, I 31008 Pamplona, Spain
    Cancer Res 62:3167-74. 2002
  8. ncbi Biologic therapy of liver tumors
    Jesus Prieto
    Division of Hepatology and Gene Therapy, Fundación para la Investigación Médica Aplicada FIMA, University of Navarra, Avenida Pio XII s n, 31080 Pamplona, Spain
    Surg Clin North Am 84:673-96. 2004
  9. ncbi Clinical implications of antigen transfer mechanisms from malignant to dendritic cells. exploiting cross-priming
    Ainhoa Arina
    Centro de Investigación Médica Aplicada CIMA, School of Medicine and Cell Therapy Area Clínica Universitaria, University of Navarra, Pamplona, Spain
    Exp Hematol 30:1355-64. 2002
  10. ncbi Interleukin-15 in gene therapy of cancer
    Maria C Ochoa
    Center for Applied Medical Research, University of Navarra, Avda Pio XII, 55 31008 Pamplona, Spain
    Curr Gene Ther 13:15-30. 2013

Collaborators

Detail Information

Publications23

  1. ncbi Intratumoral injection of dendritic cells engineered to secrete interleukin-12 by recombinant adenovirus in patients with metastatic gastrointestinal carcinomas
    Guillermo Mazzolini
    Division of Hepatology and Gene Therapy, Department of Radiology, Clinica Universitaria School of Medicine, University of Navarra, C Irunlarrea, S N, 31008 Pamplona, Spain
    J Clin Oncol 23:999-1010. 2005
    ..Secondarily, we have evaluated biologic effects and antitumoral activity...
  2. ncbi Gene therapy of cancer with interleukin-12
    Guillermo Mazzolini
    Division of Hepatology and Gene Therapy, Department of Medicine, Centro de Investigación Médica Aplicada FIMA, School of Medicine and Clinica Universitaria, University of Navarra, Pamplona, Spain
    Curr Pharm Des 9:1981-91. 2003
    ....
  3. ncbi Anti-ICAM-2 monoclonal antibody synergizes with intratumor gene transfer of interleukin-12 inhibiting activation-induced T-cell death
    Ignacio Melero
    Centro de Investigación Médica Aplicada CIMA, Facultad de Medicina, Gene Therapy Unit, Universidad de Navarra, 31008 Pamplona, Spain
    Clin Cancer Res 9:3546-54. 2003
    ..We sought to design combined therapy strategies with AdCMVIL-12 plus anti-ICAM-2 mAbs and to identify their mechanism of action...
  4. ncbi Dendritic cells delivered inside human carcinomas are sequestered by interleukin-8
    Esperanza Feijoo
    Division of Hepatology and Gene Therapy, Clinica Universitaria School of Medicine, Foundation for Applied Medical Research, Universidad de Navarra, Pamplona, Spain
    Int J Cancer 116:275-81. 2005
    ..Impairment of DC migration toward lymphoid tissue could be involved in cancer immune evasion...
  5. ncbi Potentiation of therapeutic immune responses against malignancies with monoclonal antibodies
    Oihana Murillo
    Centro de Investigación Médica Aplicada and Clinica Universitaria, Universidad de Navarra, Pamplona, Spain
    Clin Cancer Res 9:5454-64. 2003
    ..This new group of antitumor agents holds promise for at least additive effects with conventional therapies of cancer and deserves intensive translational research...
  6. ncbi Positron emission tomography imaging of adenoviral-mediated transgene expression in liver cancer patients
    Ivan Penuelas
    Department of Nuclear Medicine, Clinica Universitaria de Navarro, Pamplona, Spain
    Gastroenterology 128:1787-95. 2005
    ....
  7. ncbi An anti-ICAM-2 (CD102) monoclonal antibody induces immune-mediated regressions of transplanted ICAM-2-negative colon carcinomas
    Ignacio Melero
    Gene Therapy Unit, Department of Medicine, University of Navarra School of Medicine, C Irunlarrea, I 31008 Pamplona, Spain
    Cancer Res 62:3167-74. 2002
    ....
  8. ncbi Biologic therapy of liver tumors
    Jesus Prieto
    Division of Hepatology and Gene Therapy, Fundación para la Investigación Médica Aplicada FIMA, University of Navarra, Avenida Pio XII s n, 31080 Pamplona, Spain
    Surg Clin North Am 84:673-96. 2004
    ..Combination of biological modifiers, gene therapy, and cell therapy will hopefully provide efficient means to combat inoperable neoplasms in a not-very-distant future...
  9. ncbi Clinical implications of antigen transfer mechanisms from malignant to dendritic cells. exploiting cross-priming
    Ainhoa Arina
    Centro de Investigación Médica Aplicada CIMA, School of Medicine and Cell Therapy Area Clínica Universitaria, University of Navarra, Pamplona, Spain
    Exp Hematol 30:1355-64. 2002
    ..Artificial enhancement of tumor antigen cross-presentation and control of the immune-promoting status of the antigen-presenting DC will have important therapeutic implications in the near future...
  10. ncbi Interleukin-15 in gene therapy of cancer
    Maria C Ochoa
    Center for Applied Medical Research, University of Navarra, Avda Pio XII, 55 31008 Pamplona, Spain
    Curr Gene Ther 13:15-30. 2013
    ..Detailed mechanistic knowledge of IL-15 biology is envisaged to make the most of a powerful immunotherapeutic tool ranked as one of the most promising for cancer immunotherapy...
  11. ncbi Effective tumor immunotherapy: start the engine, release the brakes, step on the gas pedal,...and get ready to face autoimmunity
    Iñigo Tirapu
    Gene Therapy Division, Facultad de Medicina and Clinica Universitaria, Universidad de Navarra, Pamplona, Spain
    Arch Immunol Ther Exp (Warsz) 50:13-8. 2002
    ....
  12. ncbi Gene therapy of liver diseases
    Jesus Prieto
    Department of Internal Medicine, Clinica Universitaria de Navarra, Avda Pio XII 36, 31008 Pamplona, Spain
    Expert Opin Biol Ther 4:1073-91. 2004
    ..Recent progress in vector technology and imaging techniques, allowing in vivo assessment of gene expression, will facilitate the development of clinical applications of gene therapy...
  13. ncbi Upregulation of natural killer cells functions underlies the efficacy of intratumorally injected dendritic cells engineered to produce interleukin-12
    Mercedes Rodriguez-Calvillo
    Gene Therapy Unit, Department of Internal Medicine, University of Navarra, Pamplona, Spain
    Exp Hematol 30:195-204. 2002
    ..The aim of this work was to study the possible involvement of natural killer (NK) cells in this setting...
  14. doi Antitumor immunotherapeutic and toxic properties of an HDL-conjugated chimeric IL-15 fusion protein
    Maria C Ochoa
    Center for Applied Medical Research, University of Navarra, Pamplona, Spain
    Cancer Res 73:139-49. 2013
    ..Sushi-IL-15-Apo as a recombinant protein was also bioactive in vivo, became conjugated to HDL, and displayed immunotherapeutic effects against metastatic disease...
  15. ncbi Positron emission tomography and gene therapy: basic concepts and experimental approaches for in vivo gene expression imaging
    Ivan Penuelas
    Department of Nuclear Medicine, Clinica Universitaria de Navarra, Pamplona, Spain
    Mol Imaging Biol 6:225-38. 2004
    ....
  16. ncbi Phase I trial of intratumoral injection of an adenovirus encoding interleukin-12 for advanced digestive tumors
    Bruno Sangro
    Liver Unit, Division of Gene Therapy, Department of Internal Medicine, Clinica Universitaria, University of Navarre, Ap 4209 Pamplona 31080, Spain
    J Clin Oncol 22:1389-97. 2004
    ..To evaluate the feasibility and safety of intratumoral injection of an adenoviral vector encoding human interleukin-12 genes (Ad.IL-12) and secondarily, its biologic effect for the treatment of advanced digestive tumors...
  17. ncbi Immunotherapy and immunoescape in colorectal cancer
    Guillermo Mazzolini
    Liver Unit, Facutad de Ciencias Biomédicas, Universidad Austral, Av Presidente Perón 1500, 1635 Derqui Pilar, Buenos Aires, Argentina
    World J Gastroenterol 13:5822-31. 2007
    ....
  18. ncbi Cytokine gene transfer for cancer therapy
    Osvaldo L Podhajcer
    Gene Therapy Laboratory, Instituto Leloir CONICET, University of Buenos Aires, Av Patricias Argentinas 435, C1405BWE Buenos Aires, Argentina
    Cytokine Growth Factor Rev 18:183-94. 2007
    ....
  19. ncbi [In vivo evaluation of gene transfer]
    Guillermo Mazzolini
    Medicina (B Aires) 62:375-6. 2002
  20. ncbi Intratumoural administration of dendritic cells: hostile environment and help by gene therapy
    Eduardo Huarte
    University of Navarra School of Medicine, Gene Therapy Unit, Centro Investigación Médica Aplicada CIMA, Avda Pio XII, 55, 31080 Pamplona, Spain
    Expert Opin Biol Ther 5:7-22. 2005
    ..Several molecular strategies are being devised to interfere with the immunosuppressive actions of these substances and to further enhance the level of anticancer immunity achieved after artificial release of DCs intratumourally...
  21. ncbi Improving efficacy of interleukin-12-transfected dendritic cells injected into murine colon cancer with anti-CD137 monoclonal antibodies and alloantigens
    Iñigo Tirapu
    Gene Therapy Division, Fundacion para la Investigacion Medica Aplicada, University of Navarre, Irunlarrea s n 31008 Pamplona, Navarre, Spain
    Int J Cancer 110:51-60. 2004
    ..Supplementary Material for this article can be found on the International Journal of Cancer website at http://www.interscience.wiley.com/jpages/0020-7136/suppmat/index.html...
  22. ncbi MAGE antigens: therapeutic targets in hepatocellular carcinoma?
    Pablo Sarobe
    J Hepatol 40:155-8. 2004
  23. ncbi [Role of interleukin-12 in cancer immunotherapy]
    Guillermo Mazzolini
    Medicina (B Aires) 64:77-8. 2004