Research Topics
Genomes and Genes | Jose M MatoSummaryAffiliation: University of Navarra Country: Spain Publications
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Publications
S-Adenosylmethionine: a control switch that regulates liver functionJose M Mato
Division of Hepatology and Gene Therapy, School of Medicine, University of Navarra, 31008 Pamplona, Spain
FASEB J 16:15-26. 2002..With the availability of AdoMet as a nutritional supplement and evidence of its beneficial role in various liver diseases, this review offers insight into its mechanism of action...- S-adenosylmethionine in alcoholic liver cirrhosis: a randomized, placebo-controlled, double-blind, multicenter clinical trialJ M Mato
Department of Medicine, University of Navarra, Pamplona, Spain
J Hepatol 30:1081-9. 1999..The aim of this study was to investigate the effects of AdoMet treatment in human alcoholic liver cirrhosis... - NO sensitizes rat hepatocytes to proliferation by modifying S-adenosylmethionine levelsElena R Garcia-Trevijano
División de Hepatología y Terapia Génica, Departamento de Medicina Interna, Facultad de Medicina, Universidad de Navarra, Pamplona, Spain
Gastroenterology 122:1355-63. 2002..We have studied the modulation of hepatocyte growth factor-induced proliferation by NO through the regulation of S-adenosylmethionine levels... - Methionine adenosyltransferase II beta subunit gene expression provides a proliferative advantage in human hepatomaMaria L Martinez-Chantar
División de Hepatología y Terapia Génica, Departamento de Medicina Interna, Universidad de Navarra, Pamplona, Spain
Gastroenterology 124:940-8. 2003..The beta subunit has been cloned and shown to lower the K(m) of methionine adenosyltransferase II alpha2 (the MAT2A product) for methionine and to render the enzyme more susceptible to S-adenosylmethionine inhibition... 
Proteomic analysis of human hepatoma cells expressing methionine adenosyltransferase I/III: Characterization of DDX3X as a target of S-adenosylmethioninePaul C Schröder
Division of Hepatology and Gene Therapy, CIMA, University of Navarra, 31008 Pamplona, Spain
J Proteomics 75:2855-68. 2012..This article is part of a Special Issue entitled: Proteomics: The clinical link...- Molecular profiling of hepatocellular carcinoma in mice with a chronic deficiency of hepatic s-adenosylmethionine: relevance in human liver diseasesEnrique Santamaria
Division of Hepatology and Gene Therapy, CIMA, University of Navarra, 31008 Pamplona, Spain
J Proteome Res 5:944-53. 2006..Interestingly, seven of these genes were also found to be down-regulated in a pretumoral condition such as cirrhosis, while depletion of only one marker was assessed in less severe liver disorders... - Expression of Wilms' tumor suppressor in the liver with cirrhosis: relation to hepatocyte nuclear factor 4 and hepatocellular functionCarmen Berasain
Division of Hepatology and Gene Therapy, Department of Medicine, Clinica Universitaria, University of Navarra, Pamplona, Spain
Hepatology 38:148-57. 2003..WT1 is reexpressed in the cirrhotic liver in relation to disease progression and may play a role in the development of hepatic insufficiency in cirrhosis... - Oxidation of specific methionine and tryptophan residues of apolipoprotein A-I in hepatocarcinogenesisJokin Fernández-Irigoyen
Division of Hepatology and Gene Therapy, CIMA, Universidad de Navarra, 31008 Pamplona, Spain
Proteomics 5:4964-72. 2005.... - MethylthioadenosineMatias A Avila
Division of Hepatology and Gene Therapy, F I M A, University of Navarra, Pamplona, Spain
Int J Biochem Cell Biol 36:2125-30. 2004..Finally, observations carried out in models of liver damage and cancer demonstrate a therapeutic potential for MTA that deserves further consideration... - Methylthioadenosine phosphorylase gene expression is impaired in human liver cirrhosis and hepatocarcinomaCarmen Berasain
Division of Hepatology and Gene Therapy, CIMA, Facultad de Medicina, Universidad de Navarra 31008 Pamplona, Spain
Biochim Biophys Acta 1690:276-84. 2004..Given the recently proposed tumor suppressor activity of MTAP, our observations can be relevant to the elucidation of the molecular mechanisms of multistep hepatocarcinogenesis... - Importance of a deficiency in S-adenosyl-L-methionine synthesis in the pathogenesis of liver injuryM Luz Martínez-Chantar
Division of Hepatology and Gene Therapy, School of Medicine, University of Navarra, Pamplona, Spain
Am J Clin Nutr 76:1177S-82S. 2002..Since then, it has been suspected that a deficiency in hepatic SAMe may contribute to the pathogenesis of the liver in cirrhosis. The studies reviewed here are consistent with this hypothesis... - A signature of six genes highlights defects on cell growth and specific metabolic pathways in murine and human hepatocellular carcinomaPaul C Schröder
Division of Hepatology and Gene Therapy, Proteomics, Genomics and Bioinformatics Unit, Center for Applied Medical Research, University of Navarra, Pamplona, Spain
Funct Integr Genomics 11:419-29. 2011..In addition to revealing the impairment of central metabolic pathways for liver homeostasis, further studies may probe the potential value of the reported genes for the early detection of HCC... - S-Adenosylmethionine revisited: its essential role in the regulation of liver functionMatiías A Avila
Division of Hepatology and Gene Therapy, School of Medicine, University of Navarra, 31008 Pamplona, Spain
Alcohol 27:163-7. 2002..In the present work, we review the recent findings that support this hypothesis and highlight the mechanisms behind the hepatoprotective role of AdoMet... - Spontaneous oxidative stress and liver tumors in mice lacking methionine adenosyltransferase 1AMaria L Martinez-Chantar
Division of Hepatology and Gene Therapy, Department of Medicine, School of Medicine, University of Navarra, Pamplona, Spain
FASEB J 16:1292-4. 2002..Taken together, our findings define a critical role for S-adenosylmethionine in maintaining normal hepatic function and tumorigenesis of the liver... - L-methionine availability regulates expression of the methionine adenosyltransferase 2A gene in human hepatocarcinoma cells: role of S-adenosylmethionineMaria L Martinez-Chantar
Laboratório de Proteômica, Genómica y Bioinformática, and División de Hepatología y Terapia Génica, Universidad de Navarra, Facultad de Medicina, 31008 Pamplona, Spain
J Biol Chem 278:19885-90. 2003..We conclude that MAT2A gene expression is modulated as an adaptive response of the cell to l-methionine availability through its conversion to AdoMet... - Gene expression profile of omental adipose tissue in human obesityJavier Gomez-Ambrosi
Metabolic Research Laboratory, Clinica Universitaria de Navarra, 31008 Pamplona, Spain
FASEB J 18:215-7. 2004..The genomic approach underlines the importance of adipose tissue beyond energy metabolism... - Altered liver gene expression in CCl4-cirrhotic rats is partially normalized by insulin-like growth factor-IEduardo Mirpuri
División de Hepatología y Terapia Génica, Facultad de Medicina, Departamento de Medicina Interna, Universidad de Navarra, 31008, Pamplona, Spain
Int J Biochem Cell Biol 34:242-52. 2002.... - Folding of dimeric methionine adenosyltransferase III: identification of two folding intermediatesManuel M Sánchez Del Pino
Division of Hepatology and Gene Therapy, University of Navarra, Irunlarrea 1, 31008 Pamplona, Spain
J Biol Chem 277:12061-6. 2002..We propose that the folding rate-limiting step is the formation of an intermediate, probably a structured monomer with exposed hydrophobic surfaces, that rapidly associates to form dimeric MAT III... - GARBAN: genomic analysis and rapid biological annotation of cDNA microarray and proteomic dataLuis A Martínez-Cruz
Department of Internal Medicine, Unit of Proteomics, Genomics and Bioinformatics, University of Navarra, Pamplona 31008, Spain
Bioinformatics 19:2158-60. 2003..GARBAN also provides graphical representations of the biological pathways in which all the genes/proteins participate. AVAILABILITY: http://garban.tecnun.es... - S-adenosylmethionine and proliferation: new pathways, new targetsNuria Martínez-López
Unidad de Metabolómica, CIC bioGUNE Asociacion Centro de Investigación Cooperativa en Biociencias, Parque Tecnologico de Bizkaia, Edificio 801A, 48160 Derio Bizkaia, Spain
Biochem Soc Trans 36:848-52. 2008..These new findings open a wide range of possibilities to discover novel targets for clinical applications... 
Expansion of liver cancer stem cells during aging in methionine adenosyltransferase 1A-deficient miceC Bart Rountree
Division of Gastroenterology, Children s Hospital, Los Angeles, Los Angeles, CA, USA
Hepatology 47:1288-97. 2008..This is the first demonstration of adult liver stem cells possessing tumorigenic potential without the use of a carcinogen or manipulation of tumor-suppressor or oncogene expression...- Inhibition of lipopolysaccharide-stimulated TNF-alpha promoter activity by S-adenosylmethionine and 5'-methylthioadenosineNary Veal
Keck School of Medicine of the Univ. of Southern California, 1333 San Pablo St, MMR-402, Los Angeles, CA 90033, USA
Am J Physiol Gastrointest Liver Physiol 287:G352-62. 2004..Furthermore, our study is the first to demonstrate a potent inhibitory effect on NF-kappaB promoter activity and TNF-alpha expression by a SAM's metabolite, MTA...