Jose M Mato

Summary

Affiliation: University of Navarra
Country: Spain

Publications

  1. ncbi S-Adenosylmethionine: a control switch that regulates liver function
    Jose M Mato
    Division of Hepatology and Gene Therapy, School of Medicine, University of Navarra, 31008 Pamplona, Spain
    FASEB J 16:15-26. 2002
  2. ncbi S-adenosylmethionine in alcoholic liver cirrhosis: a randomized, placebo-controlled, double-blind, multicenter clinical trial
    J M Mato
    Department of Medicine, University of Navarra, Pamplona, Spain
    J Hepatol 30:1081-9. 1999
  3. pmc Functional proteomics of nonalcoholic steatohepatitis: mitochondrial proteins as targets of S-adenosylmethionine
    Enrique Santamaria
    Laboratório de Proteômica, Genómica y Bioinformática, and División de Hepatología y Terapia Génica, Facultad de Medicina, Universidad de Navarra, 31008 Pamplona, Spain
    Proc Natl Acad Sci U S A 100:3065-70. 2003
  4. ncbi Oxidation of specific methionine and tryptophan residues of apolipoprotein A-I in hepatocarcinogenesis
    Jokin Fernández-Irigoyen
    Division of Hepatology and Gene Therapy, CIMA, Universidad de Navarra, 31008 Pamplona, Spain
    Proteomics 5:4964-72. 2005
  5. ncbi 5'-methylthioadenosine modulates the inflammatory response to endotoxin in mice and in rat hepatocytes
    Henar Hevia
    División de Hepatología y Terapia Génica, Departamento de Medicina Interna, CIMA, Universidad de Navarra, Pamplona, Spain
    Hepatology 39:1088-98. 2004
  6. ncbi S-adenosylmethionine and methylthioadenosine are antiapoptotic in cultured rat hepatocytes but proapoptotic in human hepatoma cells
    Eduardo Ansorena
    Departamento de Bioquimica, División de Hepatología y Terapia Génica, Departamento de Medicina Interna, Universidad de Navarra, Pamplona, Spain
    Hepatology 35:274-80. 2002
  7. ncbi Molecular profiling of hepatocellular carcinoma in mice with a chronic deficiency of hepatic s-adenosylmethionine: relevance in human liver diseases
    Enrique Santamaria
    Division of Hepatology and Gene Therapy, CIMA, University of Navarra, 31008 Pamplona, Spain
    J Proteome Res 5:944-53. 2006
  8. ncbi Methylthioadenosine phosphorylase gene expression is impaired in human liver cirrhosis and hepatocarcinoma
    Carmen Berasain
    Division of Hepatology and Gene Therapy, CIMA, Facultad de Medicina, Universidad de Navarra 31008 Pamplona, Spain
    Biochim Biophys Acta 1690:276-84. 2004
  9. ncbi Methionine adenosyltransferase II beta subunit gene expression provides a proliferative advantage in human hepatoma
    Maria L Martinez-Chantar
    División de Hepatología y Terapia Génica, Departamento de Medicina Interna, Universidad de Navarra, Pamplona, Spain
    Gastroenterology 124:940-8. 2003
  10. doi Proteomic analysis of human hepatoma cells expressing methionine adenosyltransferase I/III: Characterization of DDX3X as a target of S-adenosylmethionine
    Paul C Schröder
    Division of Hepatology and Gene Therapy, CIMA, University of Navarra, 31008 Pamplona, Spain
    J Proteomics 75:2855-68. 2012

Collaborators

Detail Information

Publications27

  1. ncbi S-Adenosylmethionine: a control switch that regulates liver function
    Jose M Mato
    Division of Hepatology and Gene Therapy, School of Medicine, University of Navarra, 31008 Pamplona, Spain
    FASEB J 16:15-26. 2002
    ..With the availability of AdoMet as a nutritional supplement and evidence of its beneficial role in various liver diseases, this review offers insight into its mechanism of action...
  2. ncbi S-adenosylmethionine in alcoholic liver cirrhosis: a randomized, placebo-controlled, double-blind, multicenter clinical trial
    J M Mato
    Department of Medicine, University of Navarra, Pamplona, Spain
    J Hepatol 30:1081-9. 1999
    ..The aim of this study was to investigate the effects of AdoMet treatment in human alcoholic liver cirrhosis...
  3. pmc Functional proteomics of nonalcoholic steatohepatitis: mitochondrial proteins as targets of S-adenosylmethionine
    Enrique Santamaria
    Laboratório de Proteômica, Genómica y Bioinformática, and División de Hepatología y Terapia Génica, Facultad de Medicina, Universidad de Navarra, 31008 Pamplona, Spain
    Proc Natl Acad Sci U S A 100:3065-70. 2003
    ..Importantly, we found the expression of these mitochondrial proteins was abnormal in obob mice and obese patients who are at risk for nonalcoholic steatohepatitis...
  4. ncbi Oxidation of specific methionine and tryptophan residues of apolipoprotein A-I in hepatocarcinogenesis
    Jokin Fernández-Irigoyen
    Division of Hepatology and Gene Therapy, CIMA, Universidad de Navarra, 31008 Pamplona, Spain
    Proteomics 5:4964-72. 2005
    ....
  5. ncbi 5'-methylthioadenosine modulates the inflammatory response to endotoxin in mice and in rat hepatocytes
    Henar Hevia
    División de Hepatología y Terapia Génica, Departamento de Medicina Interna, CIMA, Universidad de Navarra, Pamplona, Spain
    Hepatology 39:1088-98. 2004
    ..In conclusion, these observations demonstrate novel immunomodulatory properties for MTA that may be of value in the management of inflammatory diseases...
  6. ncbi S-adenosylmethionine and methylthioadenosine are antiapoptotic in cultured rat hepatocytes but proapoptotic in human hepatoma cells
    Eduardo Ansorena
    Departamento de Bioquimica, División de Hepatología y Terapia Génica, Departamento de Medicina Interna, Universidad de Navarra, Pamplona, Spain
    Hepatology 35:274-80. 2002
    ..These effects may participate in the hepatoprotective and chemopreventive properties of this safe and well-tolerated drug...
  7. ncbi Molecular profiling of hepatocellular carcinoma in mice with a chronic deficiency of hepatic s-adenosylmethionine: relevance in human liver diseases
    Enrique Santamaria
    Division of Hepatology and Gene Therapy, CIMA, University of Navarra, 31008 Pamplona, Spain
    J Proteome Res 5:944-53. 2006
    ..Interestingly, seven of these genes were also found to be down-regulated in a pretumoral condition such as cirrhosis, while depletion of only one marker was assessed in less severe liver disorders...
  8. ncbi Methylthioadenosine phosphorylase gene expression is impaired in human liver cirrhosis and hepatocarcinoma
    Carmen Berasain
    Division of Hepatology and Gene Therapy, CIMA, Facultad de Medicina, Universidad de Navarra 31008 Pamplona, Spain
    Biochim Biophys Acta 1690:276-84. 2004
    ..Given the recently proposed tumor suppressor activity of MTAP, our observations can be relevant to the elucidation of the molecular mechanisms of multistep hepatocarcinogenesis...
  9. ncbi Methionine adenosyltransferase II beta subunit gene expression provides a proliferative advantage in human hepatoma
    Maria L Martinez-Chantar
    División de Hepatología y Terapia Génica, Departamento de Medicina Interna, Universidad de Navarra, Pamplona, Spain
    Gastroenterology 124:940-8. 2003
    ..The beta subunit has been cloned and shown to lower the K(m) of methionine adenosyltransferase II alpha2 (the MAT2A product) for methionine and to render the enzyme more susceptible to S-adenosylmethionine inhibition...
  10. doi Proteomic analysis of human hepatoma cells expressing methionine adenosyltransferase I/III: Characterization of DDX3X as a target of S-adenosylmethionine
    Paul C Schröder
    Division of Hepatology and Gene Therapy, CIMA, University of Navarra, 31008 Pamplona, Spain
    J Proteomics 75:2855-68. 2012
    ..This article is part of a Special Issue entitled: Proteomics: The clinical link...
  11. ncbi A signature of six genes highlights defects on cell growth and specific metabolic pathways in murine and human hepatocellular carcinoma
    Paul C Schröder
    Division of Hepatology and Gene Therapy, Proteomics, Genomics and Bioinformatics Unit, Center for Applied Medical Research, University of Navarra, Pamplona, Spain
    Funct Integr Genomics 11:419-29. 2011
    ..In addition to revealing the impairment of central metabolic pathways for liver homeostasis, further studies may probe the potential value of the reported genes for the early detection of HCC...
  12. ncbi Expression of Wilms' tumor suppressor in the liver with cirrhosis: relation to hepatocyte nuclear factor 4 and hepatocellular function
    Carmen Berasain
    Division of Hepatology and Gene Therapy, Department of Medicine, Clinica Universitaria, University of Navarra, Pamplona, Spain
    Hepatology 38:148-57. 2003
    ..WT1 is reexpressed in the cirrhotic liver in relation to disease progression and may play a role in the development of hepatic insufficiency in cirrhosis...
  13. ncbi Spontaneous oxidative stress and liver tumors in mice lacking methionine adenosyltransferase 1A
    Maria L Martinez-Chantar
    Division of Hepatology and Gene Therapy, Department of Medicine, School of Medicine, University of Navarra, Pamplona, Spain
    FASEB J 16:1292-4. 2002
    ..Taken together, our findings define a critical role for S-adenosylmethionine in maintaining normal hepatic function and tumorigenesis of the liver...
  14. ncbi NO sensitizes rat hepatocytes to proliferation by modifying S-adenosylmethionine levels
    Elena R Garcia-Trevijano
    División de Hepatología y Terapia Génica, Departamento de Medicina Interna, Facultad de Medicina, Universidad de Navarra, Pamplona, Spain
    Gastroenterology 122:1355-63. 2002
    ..We have studied the modulation of hepatocyte growth factor-induced proliferation by NO through the regulation of S-adenosylmethionine levels...
  15. ncbi Importance of a deficiency in S-adenosyl-L-methionine synthesis in the pathogenesis of liver injury
    M Luz Martínez-Chantar
    Division of Hepatology and Gene Therapy, School of Medicine, University of Navarra, Pamplona, Spain
    Am J Clin Nutr 76:1177S-82S. 2002
    ..Since then, it has been suspected that a deficiency in hepatic SAMe may contribute to the pathogenesis of the liver in cirrhosis. The studies reviewed here are consistent with this hypothesis...
  16. ncbi Regulation of mammalian liver methionine adenosyltransferase
    Fernando J Corrales
    Division of Hepatology and Gene Therapy, School of Medicine, University of Navarra, 31008 Pamplona, Spain
    J Nutr 132:2377S-2381S. 2002
    ..Therefore, knowledge of factors that regulate the activity of MAT I/III, the specific liver enzyme, is essential to understand how cellular SAM levels are controlled...
  17. ncbi S-Adenosylmethionine revisited: its essential role in the regulation of liver function
    Matiías A Avila
    Division of Hepatology and Gene Therapy, School of Medicine, University of Navarra, 31008 Pamplona, Spain
    Alcohol 27:163-7. 2002
    ..In the present work, we review the recent findings that support this hypothesis and highlight the mechanisms behind the hepatoprotective role of AdoMet...
  18. ncbi Methylthioadenosine
    Matias A Avila
    Division of Hepatology and Gene Therapy, F I M A, University of Navarra, Pamplona, Spain
    Int J Biochem Cell Biol 36:2125-30. 2004
    ..Finally, observations carried out in models of liver damage and cancer demonstrate a therapeutic potential for MTA that deserves further consideration...
  19. ncbi L-methionine availability regulates expression of the methionine adenosyltransferase 2A gene in human hepatocarcinoma cells: role of S-adenosylmethionine
    Maria L Martinez-Chantar
    Laboratório de Proteômica, Genómica y Bioinformática, and División de Hepatología y Terapia Génica, Universidad de Navarra, Facultad de Medicina, 31008 Pamplona, Spain
    J Biol Chem 278:19885-90. 2003
    ..We conclude that MAT2A gene expression is modulated as an adaptive response of the cell to l-methionine availability through its conversion to AdoMet...
  20. ncbi Gene expression profile of omental adipose tissue in human obesity
    Javier Gomez-Ambrosi
    Metabolic Research Laboratory, Clinica Universitaria de Navarra, 31008 Pamplona, Spain
    FASEB J 18:215-7. 2004
    ..The genomic approach underlines the importance of adipose tissue beyond energy metabolism...
  21. ncbi GARBAN: genomic analysis and rapid biological annotation of cDNA microarray and proteomic data
    Luis A Martínez-Cruz
    Department of Internal Medicine, Unit of Proteomics, Genomics and Bioinformatics, University of Navarra, Pamplona 31008, Spain
    Bioinformatics 19:2158-60. 2003
    ..GARBAN also provides graphical representations of the biological pathways in which all the genes/proteins participate...
  22. ncbi Altered liver gene expression in CCl4-cirrhotic rats is partially normalized by insulin-like growth factor-I
    Eduardo Mirpuri
    División de Hepatología y Terapia Génica, Facultad de Medicina, Departamento de Medicina Interna, Universidad de Navarra, 31008, Pamplona, Spain
    Int J Biochem Cell Biol 34:242-52. 2002
    ....
  23. ncbi Folding of dimeric methionine adenosyltransferase III: identification of two folding intermediates
    Manuel M Sánchez Del Pino
    Division of Hepatology and Gene Therapy, University of Navarra, Irunlarrea 1, 31008 Pamplona, Spain
    J Biol Chem 277:12061-6. 2002
    ..We propose that the folding rate-limiting step is the formation of an intermediate, probably a structured monomer with exposed hydrophobic surfaces, that rapidly associates to form dimeric MAT III...
  24. doi Surfing transcriptomic landscapes. A step beyond the annotation of chromosome 16 proteome
    Victor Segura
    ProteoRed ISCIII, Center for Applied Medical Research CIMA, University of Navarra, Pio XII, 55 Ed CIMA, 31008 Pamplona, Spain
    J Proteome Res 13:158-72. 2014
    ..SRM methods for 49 known proteins and for recombinant forms of 24 missing proteins are reported in this study. ..
  25. doi S-adenosylmethionine and proliferation: new pathways, new targets
    Nuria Martínez-López
    Unidad de Metabolómica, CIC bioGUNE Asociacion Centro de Investigación Cooperativa en Biociencias, Parque Tecnologico de Bizkaia, Edificio 801A, 48160 Derio Bizkaia, Spain
    Biochem Soc Trans 36:848-52. 2008
    ..These new findings open a wide range of possibilities to discover novel targets for clinical applications...
  26. ncbi Inhibition of lipopolysaccharide-stimulated TNF-alpha promoter activity by S-adenosylmethionine and 5'-methylthioadenosine
    Nary Veal
    Keck School of Medicine of the Univ of Southern California, 1333 San Pablo St, MMR 402, Los Angeles, CA 90033, USA
    Am J Physiol Gastrointest Liver Physiol 287:G352-62. 2004
    ..Furthermore, our study is the first to demonstrate a potent inhibitory effect on NF-kappaB promoter activity and TNF-alpha expression by a SAM's metabolite, MTA...
  27. pmc Expansion of liver cancer stem cells during aging in methionine adenosyltransferase 1A-deficient mice
    C Bart Rountree
    Division of Gastroenterology, Children s Hospital, Los Angeles, Los Angeles, CA, USA
    Hepatology 47:1288-97. 2008
    ..Clonal expansion of single CD133+CD49f+ cells revealed maintenance of bipotency. After CD133+CD49f+ cells were injected into immune-deficient mice, 3 of the 8 mice developed tumors of liver epithelial cells after 6-8 weeks...