J A Martinez


Affiliation: University of Navarra
Country: Spain


  1. Ibero Baraibar I, Romo Hualde A, González Navarro C, Zulet M, Martinez J. The urinary metabolomic profile following the intake of meals supplemented with a cocoa extract in middle-aged obese subjects. Food Funct. 2016;7:1924-31 pubmed publisher
    ..002). In conclusion, the metabolomic approach supported the compliance of the volunteers with the intervention and suggested the bioavailability of cocoa compounds within the meals. ..
  2. Yang J, Fernández Galilea M, Martínez Fernández L, Gonzalez Muniesa P, Pérez Chávez A, Martinez J, et al. Oxidative Stress and Non-Alcoholic Fatty Liver Disease: Effects of Omega-3 Fatty Acid Supplementation. Nutrients. 2019;11: pubmed publisher
    ..Future perspectives and relevant aspects that should be considered when planning new randomized controlled trials are also discussed. ..
  3. Papandreou C, Babio N, Díaz López A, Martinez Gonzalez M, Becerra Tomás N, Corella D, et al. Sleep Duration is Inversely Associated with Serum Uric Acid Concentrations and Uric Acid to Creatinine Ratio in an Elderly Mediterranean Population at High Cardiovascular Risk. Nutrients. 2019;11: pubmed publisher
    ..15, p = 0.001). The findings of this study suggest that longer sleep duration is associated with lower SUA concentrations and lower SUA to creatinine ratio. ..
  4. Bibiloni M, Julibert A, Bouzas C, Martinez Gonzalez M, Corella D, Salas Salvado J, et al. Nut Consumptions as a Marker of Higher Diet Quality in a Mediterranean Population at High Cardiovascular Risk. Nutrients. 2019;11: pubmed publisher
    ..nut consumers had better nutrient adequacy, diet quality, and adherence to the MedDiet than those non-nut consumers. ..
  5. Aranaz P, Navarro Herrera D, Zabala M, Miguéliz I, Romo Hualde A, López Yoldi M, et al. Phenolic Compounds Inhibit 3T3-L1 Adipogenesis Depending on the Stage of Differentiation and Their Binding Affinity to PPARγ. Molecules. 2019;24: pubmed publisher
    ..These data contribute to elucidate the possible mechanisms of phenolic compounds in the control of adipogenesis. ..
  6. Marín Alejandre B, Abete I, Cantero I, Riezu Boj J, Milagro F, Monreal J, et al. Association between Sleep Disturbances and Liver Status in Obese Subjects with Nonalcoholic Fatty Liver Disease: A Comparison with Healthy Controls. Nutrients. 2019;11: pubmed publisher
    ..Consequently, sleep characteristics may be added to the list of modifiable behaviors to consider in health promotion strategies and in the prevention and management of NAFLD. ..
  7. Sanchez Villegas A, Álvarez Pérez J, Toledo E, Salas Salvado J, Ortega Azorín C, Zomeño M, et al. Seafood Consumption, Omega-3 Fatty Acids Intake, and Life-Time Prevalence of Depression in the PREDIMED-Plus Trial. Nutrients. 2018;10: pubmed publisher
    ..5⁻1 g/day) was significantly associated with a lower prevalence of depression. In our study, moderate fish and LC ω-3 PUFA intake, but not high intake, was associated with lower odds of depression suggesting a U-shaped relationship. ..
  8. Beulen Y, Martinez Gonzalez M, van de Rest O, Salas Salvado J, Sorli J, Gomez Gracia E, et al. Quality of Dietary Fat Intake and Body Weight and Obesity in a Mediterranean Population: Secondary Analyses within the PREDIMED Trial. Nutrients. 2018;10: pubmed publisher
    ..It may therefore be desirable to encourage high-quality fat diets like the Mediterranean diet instead of restricting total fat intake. ..
  9. Gibney M, O Sullivan A, Flynn A, Walton J, Daniel H, Manios Y, et al. Analysis of the National Adult Nutrition Survey (Ireland) and the Food4Me Nutrition Survey Databases to Explore the Development of Food Labelling Portion Sizes for the European Union. Nutrients. 2018;11: pubmed publisher
    ..00). It is concluded that notwithstanding the variety of approaches used for dietary survey data in the EU, the present data supports using a standardized approach to food portion size quantification for food labelling in the EU. ..

More Information


  1. Galarregui C, Zulet M, Cantero I, Marín Alejandre B, Monreal J, Elorz M, et al. Interplay of Glycemic Index, Glycemic Load, and Dietary Antioxidant Capacity with Insulin Resistance in Subjects with a Cardiometabolic Risk Profile. Int J Mol Sci. 2018;19: pubmed publisher
    ..This data reinforces the concept that dietary TAC, GI, and GL are potential markers of diet quality, which have an impact on the susceptible population with a cardiometabolic risk profile. ..
  2. Cano Ibáñez N, Bueno Cavanillas A, Martinez Gonzalez M, Corella D, Salas Salvado J, Zomeño M, et al. Dietary Intake in Population with Metabolic Syndrome: Is the Prevalence of Inadequate Intake Influenced by Geographical Area? Cross-Sectional Analysis from PREDIMED-Plus Study. Nutrients. 2018;10: pubmed publisher
    ..001). Sex (women), non-smoker and physical activity were also associated to adequate nutrient intake. Geographical area influences nutrient intakes. Its effect on dietary quality should be taken into account when planning food policies. ..
  3. Sayon Orea C, Santiago S, Bes Rastrollo M, Martinez Gonzalez M, Pastor M, Moreno Aliaga M, et al. Determinants of Self-Rated Health Perception in a Sample of a Physically Active Population: PLENUFAR VI Study. Int J Environ Res Public Health. 2018;15: pubmed publisher
    ..Activities like jogging, gymnastics, biking, and track and field, and a higher consumption of fruits, vegetables and fish, were associated with better health rated perception. ..
  4. Milton Laskibar I, Aguirre L, Etxeberria U, Milagro F, Martinez J, Portillo M. Do the Effects of Resveratrol on Thermogenic and Oxidative Capacities in IBAT and Skeletal Muscle Depend on Feeding Conditions?. Nutrients. 2018;10: pubmed publisher
    ..In this tissue, resveratrol increased oxidative capacity. The combination of resveratrol and energy restriction seemingly did not improve the effects induced by the polyphenol alone. ..
  5. Janeiro M, Ramirez M, Milagro F, Martinez J, Solas M. Implication of Trimethylamine N-Oxide (TMAO) in Disease: Potential Biomarker or New Therapeutic Target. Nutrients. 2018;10: pubmed publisher
    ..Finally, the potential utility of TMAO as therapeutic target is also analyzed. ..
  6. Lopez Legarrea P, Fuller N, Zulet M, Martinez J, Caterson I. The influence of Mediterranean, carbohydrate and high protein diets on gut microbiota composition in the treatment of obesity and associated inflammatory state. Asia Pac J Clin Nutr. 2014;23:360-8 pubmed publisher
  7. Barbosa K, Volp A, Marques Rocha J, Ribeiro S, Navarro Blasco I, Zulet M, et al. Low energy and carbohydrate intake associated with higher total antioxidant capacity in apparently healthy adults. Nutrition. 2014;30:1349-54 pubmed publisher
    ..Additionally, the plasma TAC increase may be able to act as a compensatory mechanism. ..
  8. Cuervo M, Sayon Orea C, Santiago S, Martínez J. Dietary and health profiles of Spanish women in preconception, pregnancy and lactation. Nutrients. 2014;6:4434-51 pubmed publisher
    ..This information might be useful in order to implement educational programs for each population group. ..
  9. Goni L, Aray Miranda M, Martinez J, Cuervo M. [Not Available]. Nutr Hosp. 2016;33:1391-1399 pubmed publisher
  10. Romo Hualde A, Huerta A, González Navarro C, Ramos Lopez O, Moreno Aliaga M, Martinez J. Untargeted metabolomic on urine samples after ?-lipoic acid and/or eicosapentaenoic acid supplementation in healthy overweight/obese women. Lipids Health Dis. 2018;17:103 pubmed publisher
    ..Clinicaltrials.gov NCT01138774 . ..
  11. Goni L, Riezu Boj J, Milagro F, Corrales F, Ortiz L, Cuervo M, et al. Interaction between an ADCY3 Genetic Variant and Two Weight-Lowering Diets Affecting Body Fatness and Body Composition Outcomes Depending on Macronutrient Distribution: A Randomized Trial. Nutrients. 2018;10: pubmed publisher
  12. Cordero P, Milagro F, Campion J, Martinez J. Maternal methyl donors supplementation during lactation prevents the hyperhomocysteinemia induced by a high-fat-sucrose intake by dams. Int J Mol Sci. 2013;14:24422-37 pubmed publisher
    ..Maternal dietary intake also affected hepatic DNA methylation metabolism, which could be linked with the regulation of the methionine-homocysteine cycle. ..
  13. Ibero Baraibar I, Azqueta A, López de Ceráin A, Martinez J, Zulet M. Assessment of DNA damage using comet assay in middle-aged overweight/obese subjects after following a hypocaloric diet supplemented with cocoa extract. Mutagenesis. 2015;30:139-46 pubmed publisher
    ..www.clinicaltrials.gov (NCT01596309). ..
  14. Nicoletti C, Nonino C, de Oliveira B, Pinhel M, Mansego M, Milagro F, et al. DNA Methylation and Hydroxymethylation Levels in Relation to Two Weight Loss Strategies: Energy-Restricted Diet or Bariatric Surgery. Obes Surg. 2016;26:603-11 pubmed publisher
    ..Depending on the obesity treatment (diet or surgery), the DNA methylation patterns behave differently. Baseline SERPINE-1 methylation may be a predictor of weight loss values after bariatric surgery. ..
  15. request reprint
    Etxeberria U, Castilla Madrigal R, Lostao M, Martínez J, Milagro F. Trans-resveratrol induces a potential anti-lipogenic effect in lipopolysaccharide-stimulated enterocytes. Cell Mol Biol (Noisy-le-grand). 2015;61:9-16 pubmed
    ..This study envisages that trans-resveratrol might exert an important anti-lipogenic effect at intestinal level under pro-inflammatory conditions, which has not been previously described. ..
  16. Ramos Lopez O, Samblas M, Milagro F, Zulet M, Mansego M, Riezu Boj J, et al. Association of low dietary folate intake with lower CAMKK2 gene methylation, adiposity, and insulin resistance in obese subjects. Nutr Res. 2018;50:53-62 pubmed publisher
    ..Furthermore, CAMKK2 expression directly correlated with HOMA-IR values. In summary, this study suggests associations between low folate intakes, lower CAMKK2 gene methylation, and insulin resistance in obese individuals. ..
  17. request reprint
    Goñi L, Cuervo M, Santiago S, Zazpe I, Martínez J. Parity implications for anthropometrical variables, lifestyle behaviors and dietary habits in pregnant women. An Sist Sanit Navar. 2014;37:349-62 pubmed
  18. Malafarina V, Reginster J, Cabrerizo S, Bruyere O, Kanis J, Martinez J, et al. Nutritional Status and Nutritional Treatment Are Related to Outcomes and Mortality in Older Adults with Hip Fracture. Nutrients. 2018;10: pubmed publisher
    ..To conclude, in older people, the prevention of malnutrition and an early nutritional intervention can improve recovery following a hip fracture. ..
  19. Marques Rocha J, Milagro F, Mansego M, Zulet M, Bressan J, Martínez J. Expression of inflammation-related miRNAs in white blood cells from subjects with metabolic syndrome after 8 wk of following a Mediterranean diet-based weight loss program. Nutrition. 2016;32:48-55 pubmed publisher
    ..Moreover, the quality of the diet has an important effect on the miRNAs expression changes. These results should be highlighted because these miRNAs have been associated with inflammatory gene regulation and important human diseases. ..
  20. San Cristobal R, Navas Carretero S, Celis Morales C, Brennan L, Walsh M, Lovegrove J, et al. Analysis of Dietary Pattern Impact on Weight Status for Personalised Nutrition through On-Line Advice: The Food4Me Spanish Cohort. Nutrients. 2015;7:9523-37 pubmed publisher
    ..Further analysis showed that prevention of overweight must focus on limiting the intake of known deleterious foods rather than exclusively enhance healthy products. ..
  21. Etxeberria U, Arias N, Boqué N, Romo Hualde A, Macarulla M, Portillo M, et al. Metabolic faecal fingerprinting of trans-resveratrol and quercetin following a high-fat sucrose dietary model using liquid chromatography coupled to high-resolution mass spectrometry. Food Funct. 2015;6:2758-67 pubmed publisher
  22. Garcia Arellano A, Ramallal R, Ruiz Canela M, Salas Salvadó J, Corella D, Shivappa N, et al. Dietary Inflammatory Index and Incidence of Cardiovascular Disease in the PREDIMED Study. Nutrients. 2015;7:4124-38 pubmed publisher
    ..22 (1.06-1.40). Our results provide direct prospective evidence that a pro-inflammatory diet is associated with a higher risk of cardiovascular clinical events. ..
  23. Etxeberria U, Arias N, Boqué N, Macarulla M, Portillo M, Martínez J, et al. Reshaping faecal gut microbiota composition by the intake of trans-resveratrol and quercetin in high-fat sucrose diet-fed rats. J Nutr Biochem. 2015;26:651-60 pubmed publisher
  24. Ibero Baraibar I, Navas Carretero S, Abete I, Martinez J, Zulet M. Increases in plasma 25(OH)D levels are related to improvements in body composition and blood pressure in middle-aged subjects after a weight loss intervention: Longitudinal study. Clin Nutr. 2015;34:1010-7 pubmed publisher
    ..Therefore, 25(OH)D assessment is a potential marker to be accounted in metabolic measures related to blood pressure, adiposity and inflammation in obesity management. www.clinicaltrials.gov (NCT01596309). ..
  25. Møller G, Rikardt Andersen J, Ritz C, P Silvestre M, Navas Carretero S, Jalo E, et al. Higher Protein Intake Is Not Associated with Decreased Kidney Function in Pre-Diabetic Older Adults Following a One-Year Intervention-A Preview Sub-Study. Nutrients. 2018;10: pubmed publisher
    ..We found no indication of impaired kidney function after one year with a higher protein intake in pre-diabetic older adults. ..
  26. Ramos Lopez O, Riezu Boj J, Milagro F, Goni L, Cuervo M, Martinez J. Differential lipid metabolism outcomes associated with ADRB2 gene polymorphisms in response to two dietary interventions in overweight/obese subjects. Nutr Metab Cardiovasc Dis. 2018;28:165-172 pubmed publisher
    ..An energy-restricted LF diet could be more beneficial than a MHP diet to reduce serum cholesterol, LDL-c, and non-HDL-c among Gly16Gly genotype carriers. CLINICALTRIALS.GOV: Identifier: NCT02737267. ..
  27. Samblas M, Milagro F, Gómez Abellán P, Martínez J, Garaulet M. Methylation on the Circadian Gene BMAL1 Is Associated with the Effects of a Weight Loss Intervention on Serum Lipid Levels. J Biol Rhythms. 2016;31:308-17 pubmed publisher
    ..05). This research describes apparently for the first time an association between changes in the methylation of the BMAL1 gene with the intervention and the effects of a weight loss intervention on blood lipids levels. ..
  28. request reprint
    Ibero Baraibar I, Perez Cornago A, Ramirez M, Martínez J, Zulet M. An Increase in Plasma Homovanillic Acid with Cocoa Extract Consumption Is Associated with the Alleviation of Depressive Symptoms in Overweight or Obese Adults on an Energy Restricted Diet in a Randomized Controlled Trial. J Nutr. 2016;: pubmed
    ..The present results are secondary analyses of a clinical trial that was registered at www.clinicaltrials.gov as NCT01596309. ..
  29. Fallaize R, Livingstone K, Celis Morales C, Macready A, San Cristobal R, Navas Carretero S, et al. Association between Diet-Quality Scores, Adiposity, Total Cholesterol and Markers of Nutritional Status in European Adults: Findings from the Food4Me Study. Nutrients. 2018;10: pubmed publisher
    ..05). We observed no association between DQS and TC. To conclude, higher DQS, which reflect better dietary patterns, were associated with markers of better nutritional status and metabolic health. ..
  30. request reprint
    Goni L, Cuervo M, Milagro F, Martínez J. Future Perspectives of Personalized Weight Loss Interventions Based on Nutrigenetic, Epigenetic, and Metagenomic Data. J Nutr. 2016;: pubmed
    ..The integration of nutrigenetic, epigenetic, and metagenomic data may lead to the design of more personalized dietary treatments to prevent chronic diseases and to optimize the individual's response to dietary interventions. ..
  31. Goni L, Cuervo M, Milagro F, Martínez J. Influence of fat intake and BMI on the association of rs1799983 NOS3 polymorphism with blood pressure levels in an Iberian population. Eur J Nutr. 2017;56:1589-1596 pubmed publisher
    ..The present study evidenced that rs1799983 NOS3 polymorphism could be associated with hypertension and DBP among Southern Europeans, being this association influenced by dietary fat (SFA and MUFA) and body mass index. ..
  32. García Calzón S, Martínez González M, Razquin C, Arós F, Lapetra J, Martínez J, et al. Mediterranean diet and telomere length in high cardiovascular risk subjects from the PREDIMED-NAVARRA study. Clin Nutr. 2016;35:1399-1405 pubmed publisher
    ..No beneficial effect of the intervention with the MeDiet for the prevention of telomere shortening in comparison with a low-fat diet was observed. ..
  33. de la Iglesia R, Loria Kohen V, Zulet M, Martinez J, Reglero G, Ramirez de Molina A. Dietary Strategies Implicated in the Prevention and Treatment of Metabolic Syndrome. Int J Mol Sci. 2016;17: pubmed
    ..The present review summarizes some of the most relevant dietary approaches and bioactive compounds employed in the treatment of the MetS to date. ..
  34. Andriessen C, Christensen P, Vestergaard Nielsen L, Ritz C, Astrup A, Meinert Larsen T, et al. Weight loss decreases self-reported appetite and alters food preferences in overweight and obese adults: Observational data from the DiOGenes study. Appetite. 2018;125:314-322 pubmed publisher
    ..These results suggest that LCD induced weight loss decreases the appetite perceptions of overweight volunteers whilst decreasing their preference for high-fat-, high-carbohydrate-, and low-energy products. ..
  35. Ramos Lopez O, Riezu Boj J, Milagro F, Goni L, Cuervo M, Martinez J. Association of the Gly482Ser PPARGC1A gene variant with different cholesterol outcomes in response to two energy-restricted diets in subjects with excessive weight. Nutrition. 2018;47:83-89 pubmed publisher
    ..The analysis of this genetic variant might be the basis for a precise, nutrigenetic management of hypercholesterolemia based on genetic makeup. ..
  36. Arpón A, Milagro F, Razquin C, Corella D, Estruch R, Fito M, et al. Impact of Consuming Extra-Virgin Olive Oil or Nuts within a Mediterranean Diet on DNA Methylation in Peripheral White Blood Cells within the PREDIMED-Navarra Randomized Controlled Trial: A Role for Dietary Lipids. Nutrients. 2017;10: pubmed publisher
  37. Cantero I, Abete I, Monreal J, Martinez J, Zulet M. Fruit Fiber Consumption Specifically Improves Liver Health Status in Obese Subjects under Energy Restriction. Nutrients. 2017;9: pubmed publisher
    ..These results support the design of dietary patterns based on the consumption of insoluble fiber and fiber from fruits in the context of energy restriction for the management of obese patients suffering fatty liver disease. ..
  38. Arpón A, Riezu Boj J, Milagro F, Marti A, Razquin C, Martínez González M, et al. Adherence to Mediterranean diet is associated with methylation changes in inflammation-related genes in peripheral blood cells. J Physiol Biochem. 2016;73:445-455 pubmed publisher
    ..This report is apparently the first showing that adherence to MedDiet is associated with the methylation of the reported genes related to inflammation with a potential regulatory impact. ..
  39. Fito M, Melander O, Martinez J, Toledo E, Carpene C, Corella D. Advances in Integrating Traditional and Omic Biomarkers When Analyzing the Effects of the Mediterranean Diet Intervention in Cardiovascular Prevention. Int J Mol Sci. 2016;17: pubmed publisher
    ..Nevertheless, these preliminary results can help to better understand the inter-individual differences in cardiovascular risk and dietary response for further applications in personalized nutrition. ..
  40. Solas M, Milagro F, Martínez Urbistondo D, Ramirez M, Martínez J. Precision Obesity Treatments Including Pharmacogenetic and Nutrigenetic Approaches. Trends Pharmacol Sci. 2016;37:575-593 pubmed publisher
  41. van Baak M, Larsen T, Jebb S, Martinez A, Saris W, Handjieva Darlenska T, et al. Dietary Intake of Protein from Different Sources and Weight Regain, Changes in Body Composition and Cardiometabolic Risk Factors after Weight Loss: The DIOGenes Study. Nutrients. 2017;9: pubmed publisher
    ..This analysis suggests that not only the amount of dietary proteins, but also the source may be important for weight and cardiometabolic risk management. However, randomized trials are needed to test the causality of these associations. ..
  42. San Cristobal R, Navas Carretero S, Livingstone K, Celis Morales C, Macready A, Fallaize R, et al. Mediterranean Diet Adherence and Genetic Background Roles within a Web-Based Nutritional Intervention: The Food4Me Study. Nutrients. 2017;9: pubmed publisher
    ..These results suggest that a higher MedDiet adherence induces beneficial effects on metabolic outcomes, which can be affected by the genetic background in some specific markers. ..
  43. Ramos Lopez O, Arpón A, Riezu Boj J, Milagro F, Mansego M, Martinez J. DNA methylation patterns at sweet taste transducing genes are associated with BMI and carbohydrate intake in an adult population. Appetite. 2018;120:230-239 pubmed publisher
    ..0001) and carbohydrate intakes (p < 0.0001). This study suggests that methylation in genes related to sweet taste could be an epigenetic mechanism associated with obesity. ..
  44. Escoté X, Gómez Zorita S, López Yoldi M, Milton Laskibar I, Fernández Quintela A, Martínez J, et al. Role of Omentin, Vaspin, Cardiotrophin-1, TWEAK and NOV/CCN3 in Obesity and Diabetes Development. Int J Mol Sci. 2017;18: pubmed publisher
    ..Finally, a strong correlation has been found between plasma NOV/CCN3 concentration and fat mass. This adipokine improves insulin actions. ..
  45. Goni L, Qi L, Cuervo M, Milagro F, Saris W, Macdonald I, et al. Effect of the interaction between diet composition and the PPM1K genetic variant on insulin resistance and ? cell function markers during weight loss: results from the Nutrient Gene Interactions in Human Obesity: implications for dietary guidelines (. Am J Clin Nutr. 2017;106:902-908 pubmed publisher
    ..This trial was registered at controlled-trials.com as ISRCTN25867281. ..
  46. Fogelholm M, Larsen T, Westerterp Plantenga M, Macdonald I, Martinez J, Boyadjieva N, et al. PREVIEW: Prevention of Diabetes through Lifestyle Intervention and Population Studies in Europe and around the World. Design, Methods, and Baseline Participant Description of an Adult Cohort Enrolled into a Three-Year Randomised Clinical Trial. Nutrients. 2017;9: pubmed publisher
    ..PREVIEW is, to date, the largest multinational trial to address the prevention of T2D in pre-diabetic adults through diet and exercise intervention. Participants will complete the final intervention in March, 2018. ..
  47. Ramos Lopez O, Riezu Boj J, Milagro F, Martinez J. DNA methylation signatures at endoplasmic reticulum stress genes are associated with adiposity and insulin resistance. Mol Genet Metab. 2018;123:50-58 pubmed publisher
    ..This study suggests associations of methylation signatures at ER stress genes with adiposity and insulin resistance, as revealed by discriminative pathway analyses. ..
  48. Santiago S, Sayón Orea C, Babio N, Ruiz Canela M, Martí A, Corella D, et al. Yogurt consumption and abdominal obesity reversion in the PREDIMED study. Nutr Metab Cardiovasc Dis. 2016;26:468-75 pubmed publisher
    ..The aim of this study was to prospectively evaluate the association between yogurt consumption, reversion of abdominal obesity status and waist circumference change in elderly...
  49. Hernández Ruiz de Eguilaz M, Martínez de Morentin Aldabe B, Almiron Roig E, Pérez Diez S, San Cristóbal Blanco R, Navas Carretero S, et al. Multisensory influence on eating behavior: Hedonic consumption. Endocrinol Diabetes Nutr. 2018;65:114-125 pubmed publisher