J A Martinez

Summary

Affiliation: University of Navarra
Country: Spain

Publications

  1. pmc A decline in inflammation is associated with less depressive symptoms after a dietary intervention in metabolic syndrome patients: a longitudinal study
    Aurora Perez-Cornago
    Department of Nutrition, Food Science and Physiology, University of Navarra, Irunlarrea 1, Pamplona 31008, Spain
    Nutr J 13:36. 2014
  2. pmc DDAH2 mRNA expression is inversely associated with some cardiovascular risk-related features in healthy young adults
    Blanca Puchau
    Department of Nutrition and Food Science, Physiology and Toxicology, University of Navarra, Pamplona, Spain
    Dis Markers 27:37-44. 2009
  3. pmc Allelic variants of melanocortin 3 receptor gene (MC3R) and weight loss in obesity: a randomised trial of hypo-energetic high- versus low-fat diets
    Jose L Santos
    Department of Nutrition, Diabetes and Metabolism, Pontificia Universidad Catolica de Chile, Santiago, Chile
    PLoS ONE 6:e19934. 2011
  4. pmc High-throughput sequencing of microRNAs in peripheral blood mononuclear cells: identification of potential weight loss biomarkers
    Fermin I Milagro
    Department of Nutrition, Food Sciences and Physiology, University of Navarra, Pamplona, Spain
    PLoS ONE 8:e54319. 2013
  5. pmc DNA Methylation Pattern in Overweight Women under an Energy-Restricted Diet Supplemented with Fish Oil
    Cátia Lira Do Amaral
    Department of Nutrition, Food Sciences and Physiology, University of Navarra, C Irunlarrea 1, 31008 Pamplona, Spain Department of Physiology and Biophysics, Institute of Biomedical Sciences, University of Sao Paulo, Avenue Professor Lineu Prestes, 1524, 05508 900 Sao Paulo, SP, Brazil
    Biomed Res Int 2014:675021. 2014
  6. doi request reprint Sociodemographic and dietary profile of 4,471 childbearing-age women planning a pregnancy
    Marta Cuervo
    Department of Nutrition, Food Sciences and Physiology University of Navarra Pamplona Spain CIBER Fisiopatología Obesidad y Nutrición CIBERobn Instituto de Salud Carlos III Spain
    Nutr Hosp 29:337-43. 2014
  7. pmc Maternal methyl donors supplementation during lactation prevents the hyperhomocysteinemia induced by a high-fat-sucrose intake by dams
    Paúl Cordero
    Department of Nutrition, Food Science and Physiology, University of Navarra, 31008 Pamplona, Spain
    Int J Mol Sci 14:24422-37. 2013
  8. ncbi request reprint Gender differences in lifestyle determinants of overweight prevalence in a sample of Southern European children
    Susana Santiago
    Department of Food Sciences, Physiology and Toxicology, University of Navarra, Irunlarrea, 1, 31008 Pamplona, Navarra, Spain Electronic
    Obes Res Clin Pract 7:e391-400. 2013
  9. pmc APOA5 Q97X mutation identified through homozygosity mapping causes severe hypertriglyceridemia in a Chilean consanguineous family
    Catalina Dussaillant
    Department of Nutrition, Diabetes and Metabolism, School of Medicine, Pontificia Universidad Catolica de Chile, Alameda, Santiago, Chile
    BMC Med Genet 13:106. 2012
  10. pmc Beneficial Effects of the RESMENA Dietary Pattern on Oxidative Stress in Patients Suffering from Metabolic Syndrome with Hyperglycemia Are Associated to Dietary TAC and Fruit Consumption
    Rocío de la Iglesia
    Department of Nutrition, Food Sciences and Physiology, University of Navarra, Pamplona 31008, Spain
    Int J Mol Sci 14:6903-19. 2013

Collaborators

Detail Information

Publications128 found, 100 shown here

  1. pmc A decline in inflammation is associated with less depressive symptoms after a dietary intervention in metabolic syndrome patients: a longitudinal study
    Aurora Perez-Cornago
    Department of Nutrition, Food Science and Physiology, University of Navarra, Irunlarrea 1, Pamplona 31008, Spain
    Nutr J 13:36. 2014
    ..Therefore, the aim of this study was to examine the effects of a hypocaloric diet designed to reduce MetS features on self-perceived depression and the possible underlying factors...
  2. pmc DDAH2 mRNA expression is inversely associated with some cardiovascular risk-related features in healthy young adults
    Blanca Puchau
    Department of Nutrition and Food Science, Physiology and Toxicology, University of Navarra, Pamplona, Spain
    Dis Markers 27:37-44. 2009
    ....
  3. pmc Allelic variants of melanocortin 3 receptor gene (MC3R) and weight loss in obesity: a randomised trial of hypo-energetic high- versus low-fat diets
    Jose L Santos
    Department of Nutrition, Diabetes and Metabolism, Pontificia Universidad Catolica de Chile, Santiago, Chile
    PLoS ONE 6:e19934. 2011
    ..The aim of this study is to assess the association in adults between allelic variants of MC3R with weight loss induced by energy-restricted diets...
  4. pmc High-throughput sequencing of microRNAs in peripheral blood mononuclear cells: identification of potential weight loss biomarkers
    Fermin I Milagro
    Department of Nutrition, Food Sciences and Physiology, University of Navarra, Pamplona, Spain
    PLoS ONE 8:e54319. 2013
    ....
  5. pmc DNA Methylation Pattern in Overweight Women under an Energy-Restricted Diet Supplemented with Fish Oil
    Cátia Lira Do Amaral
    Department of Nutrition, Food Sciences and Physiology, University of Navarra, C Irunlarrea 1, 31008 Pamplona, Spain Department of Physiology and Biophysics, Institute of Biomedical Sciences, University of Sao Paulo, Avenue Professor Lineu Prestes, 1524, 05508 900 Sao Paulo, SP, Brazil
    Biomed Res Int 2014:675021. 2014
    ..These results suggest that the n-3 PUFA-induced changes in the expression of these genes in PBMC are not mediated by DNA methylation, although other epigenetic mechanisms cannot be discarded. ..
  6. doi request reprint Sociodemographic and dietary profile of 4,471 childbearing-age women planning a pregnancy
    Marta Cuervo
    Department of Nutrition, Food Sciences and Physiology University of Navarra Pamplona Spain CIBER Fisiopatología Obesidad y Nutrición CIBERobn Instituto de Salud Carlos III Spain
    Nutr Hosp 29:337-43. 2014
    ..The aim of this research was to assess the lifestyles of childbearing-age women planning a pregnancy and to examine the difference between primiparae and multiparae women on these lifestyles...
  7. pmc Maternal methyl donors supplementation during lactation prevents the hyperhomocysteinemia induced by a high-fat-sucrose intake by dams
    Paúl Cordero
    Department of Nutrition, Food Science and Physiology, University of Navarra, 31008 Pamplona, Spain
    Int J Mol Sci 14:24422-37. 2013
    ..Maternal dietary intake also affected hepatic DNA methylation metabolism, which could be linked with the regulation of the methionine-homocysteine cycle. ..
  8. ncbi request reprint Gender differences in lifestyle determinants of overweight prevalence in a sample of Southern European children
    Susana Santiago
    Department of Food Sciences, Physiology and Toxicology, University of Navarra, Irunlarrea, 1, 31008 Pamplona, Navarra, Spain Electronic
    Obes Res Clin Pract 7:e391-400. 2013
    ..The association between sleep duration, extracurricular sport, screen-based activities and dietary variables with prevalence of overweight in middle childhood, regarding gender differences, was assessed...
  9. pmc APOA5 Q97X mutation identified through homozygosity mapping causes severe hypertriglyceridemia in a Chilean consanguineous family
    Catalina Dussaillant
    Department of Nutrition, Diabetes and Metabolism, School of Medicine, Pontificia Universidad Catolica de Chile, Alameda, Santiago, Chile
    BMC Med Genet 13:106. 2012
    ..The aim of this study was to determine the genetic locus responsible for the severe HTG in this family...
  10. pmc Beneficial Effects of the RESMENA Dietary Pattern on Oxidative Stress in Patients Suffering from Metabolic Syndrome with Hyperglycemia Are Associated to Dietary TAC and Fruit Consumption
    Rocío de la Iglesia
    Department of Nutrition, Food Sciences and Physiology, University of Navarra, Pamplona 31008, Spain
    Int J Mol Sci 14:6903-19. 2013
    ..In conclusion, the antioxidant properties of the RESMENA diet provide further benefits to those attributable to weight loss on patients suffering Mets with hyperglycemia...
  11. pmc Short-term role of the dietary total antioxidant capacity in two hypocaloric regimes on obese with metabolic syndrome symptoms: the RESMENA randomized controlled trial
    Patricia Lopez-Legarrea
    Department of Nutrition, Food Science and Physiology, University of Navarra, Irunlarrea rd 1, Pamplona, 31008, Spain
    Nutr Metab (Lond) 10:22. 2013
    ..Dietary total antioxidant capacity (TAC) is gaining importance in order to assess the quality of the diet...
  12. doi request reprint Interplay of early-life nutritional programming on obesity, inflammation and epigenetic outcomes
    J Alfredo Martinez
    Department of Nutrition, Food Science, Physiology and Toxicology, University of Navarra, Pamplona, Spain
    Proc Nutr Soc 71:276-83. 2012
    ..These approaches will allow diagnosis and prognosis implementation and facilitate therapeutic strategies in a personalised 'epigenomically modelled' manner to combat obesity and inflammation...
  13. pmc Chronologically scheduled snacking with high-protein products within the habitual diet in type-2 diabetes patients leads to a fat mass loss: a longitudinal study
    Santiago Navas-Carretero
    Department of Nutrition, Food Science, Physiology and Toxicology, University of Navarra, Pamplona, Spain
    Nutr J 10:74. 2011
    ....
  14. pmc Relationship of oxidized low density lipoprotein with lipid profile and oxidative stress markers in healthy young adults: a translational study
    Kiriaque B F Barbosa
    Nutrition Center, Federal University of Sergipe, Aracaju, Brazil
    Lipids Health Dis 10:61. 2011
    ..Thus, the aim of this study was to assess plasma ox-LDL concentrations and the potential association with oxidative stress markers as well as with anthropometric and metabolic features in healthy young adults...
  15. pmc High-fat diet feeding alters metabolic response to fasting/non fasting conditions. Effect on caveolin expression and insulin signalling
    Ana Gómez-Ruiz
    Department of Biochemistry and Molecular Biology, University of Navarra, Pamplona, Spain
    Lipids Health Dis 10:55. 2011
    ....
  16. pmc Fat-to-glucose interconversion by hydrodynamic transfer of two glyoxylate cycle enzyme genes
    P Cordero
    Department of Nutrition and Food Sciences, Physiology and Toxicology, University of Navarra, Pamplona, Spain
    Lipids Health Dis 7:49. 2008
    ..This application could help, if adequate protocols are designed, to induce fat utilization for glucose synthesis, which might be eventually useful to reduce body fat depots in situations of obesity and diabetes...
  17. pmc Obesity induced by a pair-fed high fat sucrose diet: methylation and expression pattern of genes related to energy homeostasis
    Almudena Lomba
    Department of Nutrition and Food Sciences, Physiology and Toxicology, University of Navarra, Pamplona, Spain
    Lipids Health Dis 9:60. 2010
    ....
  18. pmc Design and evaluation of a treatment programme for Spanish adolescents with overweight and obesity. The EVASYON Study
    David Martinez-Gomez
    Department of Metabolism and Nutrition, Instituto del Frio, Institute of Food Science and Technology and Nutrition, Spanish National Research Council CSIC, Madrid, Spain
    BMC Public Health 9:414. 2009
    ....
  19. pmc Birth weight and blood lipid levels in Spanish adolescents: influence of selected APOE, APOC3 and PPARgamma2 gene polymorphisms. The AVENA Study
    Jonatan R Ruiz
    Department of Medical Physiology, School of Medicine, University of Granada, 18071 Granada, Spain
    BMC Med Genet 9:98. 2008
    ..5 years...
  20. pmc Meta-analysis on the effect of the N363S polymorphism of the glucocorticoid receptor gene (GRL) on human obesity
    Amelia Marti
    Department of Physiology and Nutrition, University of Navarra, Pamplona, Spain
    BMC Med Genet 7:50. 2006
    ..Individual studies may lack statistical power which may result in disparate results. This limitation can be overcome using meta-analytic techniques...
  21. ncbi request reprint Genotype-dependent response to energy-restricted diets in obese subjects: towards personalized nutrition
    J Alfredo Martinez
    University of Navarra, Department of Nutrition and Food Sciences, Physiology and Toxicology, C Irunlarrea, Pamplona 31008, Spain
    Asia Pac J Clin Nutr 17:119-22. 2008
    ..Therefore, this review shows preliminary evidence from human studies that support the existence of a genetic component in the fat reduction process associated to a negative energy balance...
  22. ncbi request reprint Genetics of obesity
    J Alfredo Martinez
    Department of Physiology and Nutrition, University of Navarra, 31008 Pamplona, Spain
    Public Health Nutr 10:1138-44. 2007
    ..The aim was to review and update advances in genetics of obesity...
  23. ncbi request reprint Mitochondrial oxidative stress and inflammation: an slalom to obesity and insulin resistance
    J A Martinez
    Dept Physiology and Nutrition University of Navarra, 31008 Pamplona, Spain
    J Physiol Biochem 62:303-6. 2006
    ....
  24. ncbi request reprint Obesity risk is associated with carbohydrate intake in women carrying the Gln27Glu beta2-adrenoceptor polymorphism
    J Alfredo Martinez
    Department of Physiology and Nutrition, University of Navarra, 31008 Pamplona, Spain
    J Nutr 133:2549-54. 2003
    ..01). This gene-nutrient interaction emphasizes the importance of examining the outcome of some obesity-related mutations depending on lifestyle (including diet) and may explain the heterogeneity of findings from previous studies...
  25. pmc Fruit and vegetable consumption and proinflammatory gene expression from peripheral blood mononuclear cells in young adults: a translational study
    Helen Hermana M Hermsdorff
    Department of Nutrition, Food Science, Physiology and Toxicology, University of Navarra, Pamplona, Spain
    Nutr Metab (Lond) 7:42. 2010
    ..The current study assessed the potential relationships of fruit and vegetable consumption with the plasma concentrations and mRNA expression values of some proinflammatory markers in young adults...
  26. ncbi request reprint Obesity in young Europeans: genetic and environmental influences
    J A Martinez
    Department of Physiology and Nutrition, University of Navarra, Pamplona, Spain
    Eur J Clin Nutr 54:S56-60. 2000
    ....
  27. ncbi request reprint Interactions between leptin and NPY affecting lipid mobilization in adipose tissue
    J A Martinez
    Departamento de Fisiología y Nutrición, Universidad de Navarra, Pamplona, Spain
    J Physiol Biochem 56:1-8. 2000
    ..Summing up, new evidence suggests that NPY and leptin may interact in a homeostatic loop to regulate body-fat mass and energy balance not only at the central nervous system level, but also directly at the adipocyte level...
  28. ncbi request reprint Body-weight regulation: causes of obesity
    J A Martinez
    Department of Physiology and Nutrition, University of Navarra, Pamplona, Spain
    Proc Nutr Soc 59:337-45. 2000
    ....
  29. ncbi request reprint Prevalence of obesity in Spain
    J A Martinez
    Department of Physiology and Nutrition, University of Navarra, 31008 Pamplona, Spain
    Obes Rev 5:171-2. 2004
    ..5%...
  30. pmc Dietary total antioxidant capacity is inversely related to central adiposity as well as to metabolic and oxidative stress markers in healthy young adults
    Helen Hermana M Hermsdorff
    Department of Nutrition, Food Science, Physiology and Toxicology, University of Navarra, Pamplona, Spain
    Nutr Metab (Lond) 8:59. 2011
    ..abstract:..
  31. ncbi request reprint Beta(2)-adrenergic receptor mutation and abdominal obesity risk: effect modification by gender and HDL-cholesterol
    M S Corbalán
    Department of Physiology and Nutrition, University of Navarra, 31080 Pamplona Spain
    Eur J Nutr 41:114-8. 2002
    ..A case-control study was conducted to examine the association between the 27Glu polymorphism of the beta(2)-adrenergic receptor gene (ADRB2) and the risk of abdominal obesity (defined by a waist/hip ratio: WHR higher than 0.85)...
  32. ncbi request reprint Effects of a beta3-adrenergic agonist on the immune response in diet-induced (cafeteria) obese animals
    O Lamas
    Dept of Physiology and Nutrition, University of Navarra, 31008 Pamplona, Spain
    J Physiol Biochem 59:183-91. 2003
    ..Summing up, at the immune system level, trecadrine administration increased the proportion of CD4+ spleen lymphocytes, although it was not able to restore the lymphocyte proliferative response which was depressed...
  33. ncbi request reprint Influence of two polymorphisms of the tumoral necrosis factor-alpha gene on the obesity phenotype
    M S Corbalán
    Department of Physiology and Nutrition, University of Navarra, Pamplona, Spain
    Diabetes Nutr Metab 17:17-22. 2004
    ....
  34. ncbi request reprint Basal fat oxidation and after a peak oxygen consumption test in obese women with a beta2 adrenoceptor gene polymorphism
    T Macho-Azcarate
    Department of Physiology and Nutrition, University of Navarra, Pamplona, Spain
    J Nutr Biochem 14:275-9. 2003
    ....
  35. ncbi request reprint Time-course changes in macronutrient metabolism induced by a nutritionally balanced low-calorie diet in obese women
    I Labayen
    Department of Physiology and Nutrition, C Irunlarrea, University of Navarra, 31008 Pamplona, Spain
    Int J Food Sci Nutr 55:27-35. 2004
    ..In summary, the weight and fat mass losses were associated with a lower carbohydrate oxidation, which were probably compensated by an increase in lipid oxidation without major changes in protein mobilization...
  36. ncbi request reprint TV watching modifies obesity risk linked to the 27Glu polymorphism of the ADRB2 gene in girls
    M C Ochoa
    Department of Physiology and Nutrition, University of Navarra, Pamplona, Spain
    Int J Pediatr Obes 1:83-8. 2006
    ..A matched case-control study was conducted in a population of Spanish children and adolescents (5-18 years old), to assess the interaction between the Gln27Glu polymorphism of the ADRB2 and television (TV) watching on obesity risk...
  37. doi request reprint Ascorbic acid oral treatment modifies lipolytic response and behavioural activity but not glucocorticoid metabolism in cafeteria diet-fed rats
    D F García-Diaz
    Department of Nutrition and Food Sciences, Physiology and Toxicology, University of Navarra, Pamplona, Spain
    Acta Physiol (Oxf) 195:449-57. 2009
    ..To analyse the effects of vitamin C (VC), a potent dietary antioxidant, oral supplementation on body weight gain, behavioural activity, lipolytic response and glucocorticoid metabolism in the early stages of diet-induced overweight in rats...
  38. ncbi request reprint Changes in UCP2, PPARgamma2, and c/EBPalpha gene expression induced by a neuropeptide Y (NPY) related receptor antagonist in overweight rats
    J Margareto
    Department of Physiology and Nutrition, University of Navarra, Pamplona, Spain
    Nutr Neurosci 5:13-7. 2002
    ..A.0204 may regulate body fat deposition by affecting both energy dissipation and white adipose tissue deposition, representing a potential new pharmacological strategy for obesity management...
  39. ncbi request reprint Rapid in vivo PGC-1 mRNA upregulation in brown adipose tissue of Wistar rats by a beta(3)-adrenergic agonist and lack of effect of leptin
    J Gomez-Ambrosi
    Department of Physiology and Nutrition, University of Navarra, 31008 Pamplona, Spain
    Mol Cell Endocrinol 176:85-90. 2001
    ..Moreover, our results show that PGC-1 and PPARgamma2 expression in BAT seems not to be acutely regulated by leptin...
  40. ncbi request reprint High-fat feeding period affects gene expression in rat white adipose tissue
    I P Lopez
    Department of Biochemistry and Molecular Biology, University of Navarra, Spain
    Mol Cell Biochem 275:109-15. 2005
    ....
  41. ncbi request reprint Basal and postprandial substrate oxidation rates in obese women receiving two test meals with different protein content
    I Labayen
    Department of Physiology and Nutrition, University of Navarra, Irunlarrea, 1, 31008 Pamplona, Spain
    Clin Nutr 23:571-8. 2004
    ..The aim of this intervention study was to explore the extent to which the fat mass status and the macronutrient composition of an acute dietary intake influence substrate oxidation rates...
  42. ncbi request reprint A maximal effort trial in obese women carrying the beta2-adrenoceptor Gln27Glu polymorphism
    T Macho-Azcarate
    Dept of Physiology and Nutrition, University Clinic, University of Navarra, Pamplona, Spain
    J Physiol Biochem 58:103-8. 2002
    ..These results provide evidence about a possible impact of the Gln27Glu polymorphism in the ADRB2 gene concerning a better response to exercise in obese Gln27 female subjects, in which basal insulinemia may play a role...
  43. ncbi request reprint Food consumption analysis in spanish elderly based upon the mini nutritional assessment test
    M Cuervo
    Department of Food Sciences, Nutrition, Physiology and Toxicology, University of Navarra, Pamplona, Spain
    Ann Nutr Metab 52:299-307. 2008
    ..The aim of this study was to describe and analyze specific aspects of food intake based upon the Mini Nutritional Assessment (MNA) test in a representative country sample...
  44. ncbi request reprint Up-regulation of a thermogenesis-related gene (UCP1) and down-regulation of PPARgamma and aP2 genes in adipose tissue: possible features of the antiobesity effects of a beta3-adrenergic agonist
    J Margareto
    Department of Physiology and Nutrition, University of Navarra, Pamplona, Spain
    Biochem Pharmacol 61:1471-8. 2001
    ....
  45. doi request reprint Vitamin C supplementation influences body fat mass and steroidogenesis-related genes when fed a high-fat diet
    J Campion
    Department of Physiology and Nutrition, University of Navarra, Pamplona, Spain
    Int J Vitam Nutr Res 78:87-95. 2008
    ....
  46. ncbi request reprint Prevalence of physical activity during leisure time in the European Union
    M A Martinez-Gonzalez
    Department of Epidemiology and Public Health, University of Navarra, Pamplona, Spain
    Med Sci Sports Exerc 33:1142-6. 2001
    ..To estimate the prevalence of physical activity during leisure time in adults from the 15 member states of the European Union and the relationship with sociodemographic variables...
  47. ncbi request reprint Diferential gene expression and adiposity reduction induced by ascorbic acid supplementation in a cafeteria model of obesity
    J Campion
    Department of Physiology and Nutrition, University of Navarra, Pamplona, Spain
    J Physiol Biochem 62:71-80. 2006
    ..This strategy was able to link variations in adipose tissue gene expression with markers of diet-induced obesity in rats, such as insulin resistance and body fat content...
  48. ncbi request reprint Effects of Trecadrine, a beta3-adrenergic agonist, on leptin secretion, glucose and lipid metabolism in isolated rat adipocytes
    M J Moreno-Aliaga
    Department of Physiology and Nutrition, University of Navarra, Pamplona, Spain
    Int J Obes Relat Metab Disord 26:912-9. 2002
    ..Because insulin-stimulated glucose metabolism is an important regulator of leptin expression and secretion by the adipocytes, the effects of Trecadrine on indices of adipocyte metabolism were also examined...
  49. ncbi request reprint Determinants of the adherence to an "a priori" defined Mediterranean dietary pattern
    A Sanchez-Villegas
    Department of Epidemiology and Public Health, University of Navarra, Pamplona, Spain
    Eur J Nutr 41:249-57. 2002
    ..A prospective cohort study with university level participants was initiated to study the effect of Mediterranean diet on health...
  50. ncbi request reprint Maternal weight gain induced by an obesogenic diet affects adipose accumulation, liver weight, and insulin homeostasis in the rat offspring depending on the sex
    P Cordero
    Department of Nutrition, Food Sciences and Physiology, University of Navarra, Pamplona, Spain
    J Endocrinol Invest 35:981-6. 2012
    ..The aim of this research was to analyze the influence of the maternal dietary intake before pregnancy, as well as the parental impact on the response to a transgenerational high-fat-diet in rats...
  51. ncbi request reprint Virgin olive oil supplementation and long-term cognition: the PREDIMED-NAVARRA randomized, trial
    E H Martínez-Lapiscina
    Departamento de Medicina Preventiva y Salud Publica, Facultad de Medicina Clínica Universidad de Navarra, Universidad de Navarra, C Irunlarrea n1 1, Pamplona, Navarra, E 31008, Spain
    J Nutr Health Aging 17:544-52. 2013
    ..To assess the effect on cognition of a controlled intervention testing Mediterranean diets (MedDiet)...
  52. ncbi request reprint Role of adipogenic and thermogenic genes in susceptibility or resistance to develop diet-induced obesity in rats
    N Pérez-Echarri
    Departament of Nutrition, Food Science, Physiology and Toxicology, University of Navarra, 31008 Pamplona, Spain
    J Physiol Biochem 63:317-27. 2007
    ..The compensatory adaptations through the increase in energy expenditure by changes on the expression levels of UCP1 seem not to be enough to avoid the obesity onset in the DIO group...
  53. ncbi request reprint A novel mutation Thr162Arg of the melanocortin 4 receptor gene in a Spanish children and adolescent population
    M C Ochoa
    Department of Physiology and Nutrition, University Clinic, University of Navarra, Pamplona Navarra, Spain
    Clin Endocrinol (Oxf) 66:652-8. 2007
    ..In addition, functional assays were performed for a novel MC4R mutation...
  54. ncbi request reprint Conjugated linoleic acid inhibits glucose metabolism, leptin and adiponectin secretion in primary cultured rat adipocytes
    P Pérez-Matute
    Department of Physiology and Nutrition, University of Navarra, 31008 Pamplona, Spain
    Mol Cell Endocrinol 268:50-8. 2007
    ..Furthermore, the inhibition of leptin and adiponectin production induced by CLA may contribute to insulin resistance observed in CLA-treated animals and humans...
  55. ncbi request reprint Postprandial insulin response and mitochondrial oxidation in obese men nutritionally treated to lose weight
    M D Parra
    Department of Physiology and Nutrition, University of Navarra, Pamplona, Spain
    Eur J Clin Nutr 59:334-40. 2005
    ....
  56. doi request reprint Prenatal stress increases the obesogenic effects of a high-fat-sucrose diet in adult rats in a sex-specific manner
    L Paternain
    Department of Nutrition and Food Sciences, Physiology and Toxicology, University of Navarra, C Irunlarrea 1, 31008, Pamplona, Spain
    Stress 16:220-32. 2013
    ..From these results, it can be concluded that experience of maternal stress during intrauterine development can enhance predisposition to obesity induced by a HFS diet intake...
  57. doi request reprint Effects of hyperoxia exposure on metabolic markers and gene expression in 3T3-L1 adipocytes
    P Quintero
    Department of Nutrition, Food Science, Physiology and Toxicology, University of Navarra, C Irunlarrea 1, 31008 Pamplona, Spain
    J Physiol Biochem 68:663-9. 2012
    ..To our knowledge, this is the first study analyzing the effect of hyperoxia in 3T3-L1 adipocytes...
  58. ncbi request reprint Perception of body image as indicator of weight status in the European union
    A Sanchez-Villegas
    Dpto de Epidemiología y Salud Pública, Universidad de Navarra, Pamplona, Spain
    J Hum Nutr Diet 14:93-102. 2001
    ..To identify the factors associated with an adequate perception of body image in relation to body weight...
  59. doi request reprint Il6 gene promoter polymorphism (-174G/C) influences the association between fat mass and cardiovascular risk factors
    A Moleres
    Dept of Nutrition and Food Sciences, Physiology and Toxicology, Univ of Navarra, Spain
    J Physiol Biochem 65:405-13. 2009
    ..Our results suggest that this promoter polymorphism influences the association between adiposity and some plasma markers...
  60. ncbi request reprint G allele of the -930A>G polymorphism of the CYBA gene is associated with insulin resistance in obese subjects
    M C Ochoa
    Department of Nutrition, Food Science, Physiology and Toxicology, University of Navarra, Pamplona, Spain
    J Physiol Biochem 64:127-33. 2008
    ..In conclusion, a protective effect in carriers of the -930A/G polymorphism of the p22phox gene against insulin resistance in a population of Spanish obese adults has been found...
  61. ncbi request reprint A 3 years follow-up of a Mediterranean diet rich in virgin olive oil is associated with high plasma antioxidant capacity and reduced body weight gain
    C Razquin
    Department of Nutrition and Food Sciences, Physiology and Toxicology, University of Navarra, Navarra, Spain
    Eur J Clin Nutr 63:1387-93. 2009
    ....
  62. doi request reprint The - 11391 G/A polymorphism of the adiponectin gene promoter is associated with metabolic syndrome traits and the outcome of an energy-restricted diet in obese subjects
    E Goyenechea
    Department of Nutrition and Food Sciences, Physiology and Toxicology, University of Navarra, Pamplona, Spain
    Horm Metab Res 41:55-61. 2009
    ..Carriage of the A allele therefore confers protection from weight regain, and the effect is particularly evident 32-60 weeks after the dietary intervention, when improvement in GG subjects had disappeared...
  63. ncbi request reprint Vitamin C inhibits leptin secretion and some glucose/lipid metabolic pathways in primary rat adipocytes
    D F García-Diaz
    Department of Nutrition and Food Sciences, Physiology and Toxicology, University of Navarra, Pamplona, Spain
    J Mol Endocrinol 45:33-43. 2010
    ..In summary, this experimental assay describes a specific effect of VC in isolated rat adipocytes on glucose and fat metabolism, and on the secretion/expression of important obesity-related proteins...
  64. doi request reprint A 3-year Mediterranean-style dietary intervention may modulate the association between adiponectin gene variants and body weight change
    C Razquin
    Department of Nutrition and Food Sciences, Physiology and Toxicology, University of Navarra, Irunlarrea 1, 31080, Pamplona, Navarra, Spain
    Eur J Nutr 49:311-9. 2010
    ....
  65. ncbi request reprint Serum and gene expression levels of leptin and adiponectin in rats susceptible or resistant to diet-induced obesity
    N Pérez-Echarri
    Department of Physiology and Nutrition, University of Navarra, 31008 Pamplona, Spain
    J Physiol Biochem 61:333-42. 2005
    ..However, neither changes in leptin or adiponectin seem to be involved in the adaptive mechanisms that confer resistance to high fat intake...
  66. doi request reprint A high-sucrose isocaloric pair-fed model induces obesity and impairs NDUFB6 gene function in rat adipose tissue
    A Lomba
    Department of Nutrition and Food Sciences, Physiology and Toxicology, University of Navarra, Pamplona, Spain
    J Nutrigenet Nutrigenomics 2:267-72. 2009
    ....
  67. ncbi request reprint Down-regulation of heart HFABP and UCP2 gene expression in diet-induced (cafeteria) obese rats
    A Marti
    Dpto de Fisiología y Nutrición, Universidad de Navarra, Pamplona, Spain
    J Physiol Biochem 58:69-74. 2002
    ..The down-regulation of heart HFABP and UCP2 parallels the lower lipid utilization which may account for an enhanced fat deposition. It is plausible that these two genes are regulated by the same family of transcription factors...
  68. doi request reprint Specific insulin sensitivity and leptin responses to a nutritional treatment of obesity via a combination of energy restriction and fatty fish intake
    I Abete
    Department of Physiology and Nutrition, University of Navarra, Pamplona, Spain
    J Hum Nutr Diet 21:591-600. 2008
    ..The present study aimed to investigate whether the inclusion of three fatty fish servings per week within a hypocaloric diet may have specific healthy effects on insulin and leptin functions...
  69. ncbi request reprint The risk of obesity and the Trp64Arg polymorphism of the beta(3)-adrenergic receptor: effect modification by age
    M S Corbalán
    Department of Physiology and Nutrition, University of Navarra, Pamplona, Spain
    Ann Nutr Metab 46:152-8. 2002
    ..To examine the association between the risk of obesity and the Trp64Arg polymorphism of the beta(3)-adrenergic receptor gene...
  70. ncbi request reprint [Comparison between two methods to estimate physical activity in obese women: accelerometry and self-administered questionnaire]
    C M López-Fontana
    Departamento de Fisiología y Nutrición, Universidad de Navarra, Pamplona, Navarra, Espana
    Arch Latinoam Nutr 55:257-66. 2005
    ..The estimates of PA according to the questionnaire were significantly correlated to the results of the triaxial accelerometer, thus confirming the validity of the questionnaire to assess PA in an obese population...
  71. ncbi request reprint Effects of arachidonic acid on leptin secretion and expression in primary cultured rat adipocytes
    P Pérez-Matute
    Department of Physiology and Nutrition, University of Navarra, 31008 Pamplona, Spain
    J Physiol Biochem 59:201-8. 2003
    ..These results suggest that the inhibitory effect of the arachidonic acid on leptin secretion and expression may be due, al least in part, to the increase in the anaerobic utilization of glucose...
  72. doi request reprint Influence of dietary macronutrient composition on adiposity and cellularity of different fat depots in Wistar rats
    N Boque
    Dept of Nutrition, Food Science, Physiology and Toxicology, University of Navarra, Pamplona, Spain
    J Physiol Biochem 65:387-95. 2009
    ..Finally, a new tool for analyzing histological adipose samples is presented...
  73. doi request reprint A 3-year intervention with a Mediterranean diet modified the association between the rs9939609 gene variant in FTO and body weight changes
    C Razquin
    Department of Nutrition and Food Sciences, Physiology and Toxicology, University of Navarra, Navarra, Spain
    Int J Obes (Lond) 34:266-72. 2010
    ....
  74. ncbi request reprint UCP2 muscle gene transfer modifies mitochondrial membrane potential
    A Marti
    Department of Physiology and Nutrition, University of Navarra, Pamplona, Spain
    Int J Obes Relat Metab Disord 25:68-74. 2001
    ..Our results suggest the potential involvement of UCP2 in uncoupling respiration. International Journal of Obesity (2001) 25, 68-74..
  75. ncbi request reprint Shifting to a control diet after a high-fat, high-sucrose diet intake induces epigenetic changes in retroperitoneal adipocytes of Wistar rats
    G Uriarte
    Department of Nutrition, Food Science and Physiology, University of Navarra, Pamplona, Spain
    J Physiol Biochem 69:601-11. 2013
    ..This study shed light on the reversibility of phenotypical and epigenetic changes induced by a HFS diet intake...
  76. doi request reprint Obesity and metabolic syndrome: potential benefit from specific nutritional components
    I Abete
    Dpto de Ciencias de Alimentación, Fisiología y Toxicología, Universidad de Navarra, Pamplona Navarra, Spain
    Nutr Metab Cardiovasc Dis 21:B1-15. 2011
    ..Therefore, the present review focuses on some of the most important food components currently investigated to improve and make easier the nutritional MetS treatment...
  77. ncbi request reprint Modification of RXRalpha expression according to the duration of a cafeteria diet
    J Margareto
    Department of Physiology and Nutrition, University of Navarra, Pamplona, Spain
    J Physiol Biochem 57:347-8. 2001
  78. ncbi request reprint Olive oil consumption and weight change: the SUN prospective cohort study
    M Bes-Rastrollo
    Department of Preventive Medicine and Public Health, University of Navarra, E 31008 Pamplona, Spain
    Lipids 41:249-56. 2006
    ....
  79. ncbi request reprint Decreased splenic mRNA expression levels of TNF-alpha and IL-6 in diet-induced obese animals
    O Lamas
    Department of Physiology and Nutrition, University of Navarra, C Irunlarrea, 1, 31008, Pamplona, Spain
    J Physiol Biochem 60:279-83. 2004
    ..806, p = 0.000). These findings support the hypothesis that TNF-alpha gene expression may follow different trends in obese animals adipocytes and splenocytes...
  80. ncbi request reprint Sp1-mediated transcription is involved in the induction of leptin by insulin-stimulated glucose metabolism
    M J Moreno-Aliaga
    Department of Physiology and Nutrition, School of Pharmacy, University of Navarra, Pamplona, Spain
    J Mol Endocrinol 38:537-46. 2007
    ..Together, these findings support a key role for Sp1 in the transcriptional activation of the leptin gene promoter by insulin-mediated glucose metabolism...
  81. ncbi request reprint Physical inactivity, sedentary lifestyle and obesity in the European Union
    M A Martinez-Gonzalez
    Department of Epidemiology and Public Health, University of Navarra, Pamplona, Spain
    Int J Obes Relat Metab Disord 23:1192-201. 1999
    ....
  82. ncbi request reprint Ketoconazole, an antifungal agent, protects against adiposity induced by a cafeteria diet
    J Campion
    Department of Physiology and Nutrition, University of Navarra, C Irunlarrea, 31008 Pamplona, Spain
    Horm Metab Res 36:485-91. 2004
    ..Thus, ketoconazole was able to protect against adiposity induced by a cafeteria diet, revealing an interaction between fat intake and glucocorticoids on adipose deposition...
  83. ncbi request reprint TRP64ARG polymorphism of the beta 3-adrenergic receptor gene and obesity risk: effect modification by a sedentary lifestyle
    A Marti
    Department of Physiology and Nutrition, University of Navarra, Pamplona, Spain
    Diabetes Obes Metab 4:428-30. 2002
    ..We performed a case-control study to assess the association between obesity risk and the Trp64Arg polymorphism of the beta 3-adrenergic receptor gene...
  84. ncbi request reprint The reduction of the metabolyc syndrome in Navarra-Spain (RESMENA-S) study: a multidisciplinary strategy based on chrononutrition and nutritional education, together with dietetic and psychological control
    M A Zulet
    Department of Nutrition, Food Sciences, Physiology and Toxicology, University of Navarra, Pamplona, Spain
    Nutr Hosp 26:16-26. 2011
    ..The high prevalence of metabolic syndrome (MS) in Spain requires additional efforts for prevention and treatment...
  85. ncbi request reprint Anabolic actions of a mixed beta-adrenergic agonist on nitrogen retention and protein turnover
    J A Martinez
    Department of Physiology and Nutrition, University of Navarra, Pamplona, Spain
    Horm Metab Res 23:590-3. 1991
    ..In this context, it is suggested that the anabolic effect of metaproterenol should be attributed to a reduction in muscle protein degradation rather than to changes in protein synthesis...
  86. ncbi request reprint Presence of leptin receptors in rat small intestine and leptin effect on sugar absorption
    M P Lostao
    Department of Physiology and Nutrition, University of Navarra, Pamplona, Spain
    FEBS Lett 423:302-6. 1998
    ..These results indicate for the first time that leptin has a rapid inhibitory effect on sugar absorption and demonstrate the presence of leptin receptors in the intestinal mucosa...
  87. ncbi request reprint Differences in short-term metabolic responses to a lipid load in lean (resistant) vs obese (susceptible) young male subjects with habitual high-fat consumption
    M P Marrades
    Department of Physiology and Nutrition, University of Navarra, Pamplona, Spain
    Eur J Clin Nutr 61:166-74. 2007
    ..To determine the role of macronutrients oxidation ability in the postprandial response to a high lipid load in the mechanisms conferring resistance or susceptibility to obesity...
  88. ncbi request reprint Leptin gene transfer into muscle increases lipolysis and oxygen consumption in white fat tissue in ob/ob mice
    A Marti
    Department of Physiology and Nutrition, University of Navarra, Pamplona, Spain
    Biochem Biophys Res Commun 246:859-62. 1998
    ....
  89. doi request reprint Regulation by chronic-mild stress of glucocorticoids, monocyte chemoattractant protein-1 and adiposity in rats fed on a high-fat diet
    L Paternain
    Department of Nutrition and Food Sciences, Physiology and Toxicology, University of Navarra, C Irunlarrea 1, 31008 Pamplona, Spain
    Physiol Behav 103:173-80. 2011
    ..These findings suggest that a high-fat diet could protect against a stress condition and revealed a different behavior to a stressful environment depending on the nutritional status...
  90. ncbi request reprint Gene-gene interaction between PPAR gamma 2 and ADR beta 3 increases obesity risk in children and adolescents
    M C Ochoa
    Department of Physiology and Nutrition, University of Navarra, 31080 Pamplona, Spain
    Int J Obes Relat Metab Disord 28:S37-41. 2004
    ..Our aim was to explore the synergistic contribution of the two polymorphisms: Pro12Ala of the PPAR gamma 2 gene and Trp64Arg of the ADR beta 3 gene to obesity risk in a Spanish children and adolescent population...
  91. doi request reprint Sirtuin gene expression in human mononuclear cells is modulated by caloric restriction
    A B Crujeiras
    Department of Nutrition and Food Sciences, Physiology and Toxicology, University of Navarra, Pamplona, Spain
    Eur J Clin Invest 38:672-8. 2008
    ..Therefore, the aim of this study was to assess if the gene expression of sirtuins is modulated in peripheral blood mononuclear cells (PBMC) by a hypocaloric diet devised to lose weight in humans...
  92. ncbi request reprint No evidence of association between the serotonin 2A receptor--1438G/A promoter polymorphism and childhood obesity in a Spanish population: A case-parent study and a matched case-control study
    J L Santos
    Department of Physiology and Nutrition, University of Navarra, 31080, Pamplona, Spain
    Nutr Neurosci 8:207-11. 2005
    ..Likewise, no association is suggested by the case-parent study. In conclusion, it is unlikely that the--1438 G/A polymorphism of 5HT2A gene may influence obesity in a Spanish children population...
  93. ncbi request reprint Regulation of energy balance and adiposity: a model with new approaches
    J A Martinez
    Departamento de Fisiología y Nutrición, Universidad de Navarra, Pamplona, Spain
    Rev Esp Fisiol 52:255-8. 1996
    ..This perspective supplies some additional clues to the understanding of body composition regulation as well as the potential involvement of genetic and hypothalamic disorders in the onset of obesity...
  94. ncbi request reprint Does weight loss prognosis depend on genetic make-up?
    M J Moreno-Aliaga
    Department of Physiology and Nutrition, University of Navarra, 31008 Pamplona, Spain
    Obes Rev 6:155-68. 2005
    ....
  95. ncbi request reprint Gene expression changes in rat white adipose tissue after a high-fat diet determined by differential display
    I P Lopez
    Department of Biochemistry and Molecular Biology, University of Navarra, 31080 Pamplona, Navarra, Spain
    Biochem Biophys Res Commun 318:234-9. 2004
    ....
  96. ncbi request reprint Gln27Glu polymorphism in the beta2 adrenergic receptor gene and lipid metabolism during exercise in obese women
    T Macho-Azcarate
    Department of Physiology and Nutrition, University of Navarra, Pamplona, Spain
    Int J Obes Relat Metab Disord 26:1434-41. 2002
    ..In our population, we previously found an association of higher body mass index (BMI) among women who reported more physical activity and carried the Glu27 allele as compared to non carriers with the same level of activity...
  97. ncbi request reprint Chronic mild stress induces variations in locomotive behavior and metabolic rates in high fat fed rats
    D F García-Diaz
    Department of Nutrition, Food Science, Physiology and Toxicology, University of Navarra, Pamplona, Spain
    J Physiol Biochem 63:337-46. 2007
    ..In summary, this chronic stress model did not affected weight gain in control and high fat fed animals, but induced an interaction concerning the metabolic muscle/fat repartitioning...
  98. ncbi request reprint Energy restriction in obese subjects impact differently two mitochondrial function markers
    A B Crujeiras
    Department of Nutrition and Food Sciences, Physiology and Toxicology, University of Navarra, 31008 Pamplona, Spain
    J Physiol Biochem 64:211-9. 2008
    ....
  99. ncbi request reprint Linoleic acid decreases leptin and adiponectin secretion from primary rat adipocytes in the presence of insulin
    P Pérez-Matute
    Department of Physiology and Nutrition, University of Navarra, 31008, Pamplona, Navarra, Spain
    Lipids 42:913-20. 2007
    ....