Carlos Martin

Summary

Affiliation: University of Zaragoza
Country: Spain

Publications

  1. ncbi request reprint Live tuberculosis vaccines based on phoP mutants: a step towards clinical trials
    Jesus A Gonzalo Asensio
    University of Zaragoza, Department of Microbiology, Spain
    Expert Opin Biol Ther 8:201-11. 2008
  2. pmc Molecular characterisation of Mycobacterium tuberculosis isolates in the First National Survey of Anti-tuberculosis Drug Resistance from Venezuela
    Liselotte Aristimuño
    Escuela de Medicina, Universidad Centroccidental Lisandro Alvarado, Venezuela
    BMC Microbiol 6:90. 2006
  3. doi request reprint New tuberculosis vaccines
    Carlos Martín Montañés
    Departamento de Microbiologia, Facultad de Medicina, Universidad de Zaragoza, CIBER Enfermedades Respiratorias, Zaragoza, Spain
    Enferm Infecc Microbiol Clin 29:57-62. 2011
  4. pmc Interactions of attenuated Mycobacterium tuberculosis phoP mutant with human macrophages
    Nadia L Ferrer
    Grupo de Genética de Micobacterias, Departamento de Microbiologia, Medicina Preventiva y Salud Pública, Universidad de Zaragoza, Zaragoza, Spain
    PLoS ONE 5:e12978. 2010
  5. pmc Spread of extensively drug-resistant tuberculosis
    Sofia Samper
    Emerg Infect Dis 13:647-8. 2007
  6. pmc IS-seq: a novel high throughput survey of in vivo IS6110 transposition in multiple Mycobacterium tuberculosis genomes
    Alejandro Reyes
    Center for Genome Sciences and Systems Biology, Washington University School of Medicine, St, Louis, MO 63108, USA
    BMC Genomics 13:249. 2012
  7. ncbi request reprint The dream of a vaccine against tuberculosis; new vaccines improving or replacing BCG?
    C Martin
    Eur Respir J 26:162-7. 2005
  8. ncbi request reprint The live Mycobacterium tuberculosis phoP mutant strain is more attenuated than BCG and confers protective immunity against tuberculosis in mice and guinea pigs
    Carlos Martin
    Grupo de Genética de Micobacterias, Departamento de Microbiologia, Facultad de Medicina, Universidad de Zaragoza, Spain
    Vaccine 24:3408-19. 2006
  9. ncbi request reprint Tuberculosis vaccines: past, present and future
    Carlos Martin
    Department of Microbiology and Public Health, Faculty of Medicine, University of Zaragoza, Spain
    Curr Opin Pulm Med 12:186-91. 2006
  10. pmc IS6110 mediates increased transcription of the phoP virulence gene in a multidrug-resistant clinical isolate responsible for tuberculosis outbreaks
    Carlos Y Soto
    Grupo de Genética de Micobacterias, Departamento de Microbiología Medicina Preventiva y Salud Pública, Universidad de Zaragoza, Madrid, Spain
    J Clin Microbiol 42:212-9. 2004

Collaborators

Detail Information

Publications37

  1. ncbi request reprint Live tuberculosis vaccines based on phoP mutants: a step towards clinical trials
    Jesus A Gonzalo Asensio
    University of Zaragoza, Department of Microbiology, Spain
    Expert Opin Biol Ther 8:201-11. 2008
    ..The steps that now need to be followed, to take these live vaccines towards clinical trials, are also reviewed, together with the potential of these vaccines to replace BCG...
  2. pmc Molecular characterisation of Mycobacterium tuberculosis isolates in the First National Survey of Anti-tuberculosis Drug Resistance from Venezuela
    Liselotte Aristimuño
    Escuela de Medicina, Universidad Centroccidental Lisandro Alvarado, Venezuela
    BMC Microbiol 6:90. 2006
    ..Thus, we investigated the genetic patterns of strains isolated in the first survey of anti-tuberculosis drug-resistance realised as part of the Global Project of Anti-tuberculosis Drug Resistance Surveillance (WHO/IUATLD)...
  3. doi request reprint New tuberculosis vaccines
    Carlos Martín Montañés
    Departamento de Microbiologia, Facultad de Medicina, Universidad de Zaragoza, CIBER Enfermedades Respiratorias, Zaragoza, Spain
    Enferm Infecc Microbiol Clin 29:57-62. 2011
    ..A short number of live attenuated vaccines are in advance preclinical studies and the candidates ready to enter Phase I safety trials are produced under current good manufacturing practices...
  4. pmc Interactions of attenuated Mycobacterium tuberculosis phoP mutant with human macrophages
    Nadia L Ferrer
    Grupo de Genética de Micobacterias, Departamento de Microbiologia, Medicina Preventiva y Salud Pública, Universidad de Zaragoza, Zaragoza, Spain
    PLoS ONE 5:e12978. 2010
    ....
  5. pmc Spread of extensively drug-resistant tuberculosis
    Sofia Samper
    Emerg Infect Dis 13:647-8. 2007
  6. pmc IS-seq: a novel high throughput survey of in vivo IS6110 transposition in multiple Mycobacterium tuberculosis genomes
    Alejandro Reyes
    Center for Genome Sciences and Systems Biology, Washington University School of Medicine, St, Louis, MO 63108, USA
    BMC Genomics 13:249. 2012
    ....
  7. ncbi request reprint The dream of a vaccine against tuberculosis; new vaccines improving or replacing BCG?
    C Martin
    Eur Respir J 26:162-7. 2005
    ....
  8. ncbi request reprint The live Mycobacterium tuberculosis phoP mutant strain is more attenuated than BCG and confers protective immunity against tuberculosis in mice and guinea pigs
    Carlos Martin
    Grupo de Genética de Micobacterias, Departamento de Microbiologia, Facultad de Medicina, Universidad de Zaragoza, Spain
    Vaccine 24:3408-19. 2006
    ..A high dose aerosol challenge of M. tuberculosis SO2 vaccinated guinea pigs resulted in superior levels of protection when compared with BCG vaccination, as measured by guinea pig survival and reduction in disease severity in the lung...
  9. ncbi request reprint Tuberculosis vaccines: past, present and future
    Carlos Martin
    Department of Microbiology and Public Health, Faculty of Medicine, University of Zaragoza, Spain
    Curr Opin Pulm Med 12:186-91. 2006
    ..This review will outline the most promising tuberculosis vaccine candidates from selected publications...
  10. pmc IS6110 mediates increased transcription of the phoP virulence gene in a multidrug-resistant clinical isolate responsible for tuberculosis outbreaks
    Carlos Y Soto
    Grupo de Genética de Micobacterias, Departamento de Microbiología Medicina Preventiva y Salud Pública, Universidad de Zaragoza, Madrid, Spain
    J Clin Microbiol 42:212-9. 2004
    ..smegmatis with the resulting plasmid. Primer extension analysis showed that phoP transcription was strongly upregulated when the promoter region contained IS6110, as in the case of the B strain...
  11. pmc Functional and genetic characterization of the tap efflux pump in Mycobacterium bovis BCG
    Santiago Ramón-García
    Departamento de Microbiologia, Medicina Preventiva y Salud Pública, Universidad de Zaragoza, Zaragoza, Spain
    Antimicrob Agents Chemother 56:2074-83. 2012
    ..These findings emphasize the important role of the Tap efflux pump in bacterial physiology and intrinsic drug resistance...
  12. pmc The Mycobacterium tuberculosis phoPR operon is positively autoregulated in the virulent strain H37Rv
    Jesús Gonzalo-Asensio
    Departamento de Microbiologia, Medicina Preventiva y Salud Pública, Facultad de Medicina, Universidad de Zaragoza, C Domingo Miral s n, 50009 Zaragoza, Spain
    J Bacteriol 190:7068-78. 2008
    ..Finally, we discuss the possible role in virulence of a single point mutation found in the phoP gene from the attenuated H37Ra strain but not in virulent members of the M. tuberculosis complex...
  13. pmc PhoP: a missing piece in the intricate puzzle of Mycobacterium tuberculosis virulence
    Jesús Gonzalo-Asensio
    Grupo de Genética de Micobacterias, Departamento de Microbiologia, Facultad de Medicina, Universidad de Zaragoza, Zaragoza, Spain
    PLoS ONE 3:e3496. 2008
    ..Altogether, these findings indicate that PhoP orchestrates a variety of functions implicated in M. tuberculosis virulence and persistence, making phoP mutants promising vaccine candidates...
  14. pmc Global study of IS6110 in a successful Mycobacterium tuberculosis strain: clues for deciphering its behavior and for its rapid detection
    María Isabel Millán-Lou
    IIS Aragón, Hospital Universitario Miguel Servet, Zaragoza, Spain
    J Clin Microbiol 51:3631-7. 2013
    ..As a result of this analysis, a rapid method for detecting this particular M. tuberculosis strain has been designed. ..
  15. doi request reprint Construction, characterization and preclinical evaluation of MTBVAC, the first live-attenuated M. tuberculosis-based vaccine to enter clinical trials
    Ainhoa Arbués
    Grupo de Genética de Micobacterias, Dpto Microbiologia, Medicina Preventiva y Salud Pública, Universidad de Zaragoza, C Domingo Miral s n, 50009 Zaragoza, Spain CIBER Enfermedades Respiratorias, Instituto de Salud Carlos III, Madrid, Spain
    Vaccine 31:4867-73. 2013
    ..These features have enabled MTBVAC to be the first live attenuated M. tuberculosis vaccine to enter clinical evaluation. ..
  16. ncbi request reprint Characterization of tetracycline resistance mediated by the efflux pump Tap from Mycobacterium fortuitum
    Santiago Ramón-García
    Departamento de Microbiologia, Medicina Preventiva y Salud Pública, Universidad de Zaragoza, 50009 Zaragoza, Spain
    J Antimicrob Chemother 57:252-9. 2006
    ..For all these studies, we produced Tap protein in Mycobacterium smegmatis...
  17. pmc Mapping IS6110 in high-copy number Mycobacterium tuberculosis strains shows specific insertion points in the Beijing genotype
    Henar Alonso
    Grupo de Genética de Micobacterias, Departamento de Microbiologia, Medicina Preventiva y Salud Pública, Universidad de Zaragoza, C Domingo Miral sn, 50009, Zaragoza, Spain
    BMC Genomics 14:422. 2013
    ..This work studies the insetion points of IS6110 in high-copy clinical isolates specifically focusing on the Beijing genotype...
  18. doi request reprint Intracellular replication of attenuated Mycobacterium tuberculosis phoP mutant in the absence of host cell cytotoxicity
    Nadia L Ferrer
    Grupo de Genética de Micobacterias, Departamento de Microbiologia, Medicina Preventiva y Salud Pública, Universidad de Zaragoza, Spain
    Microbes Infect 11:115-22. 2009
    ..The ability of M. tuberculosis phoP mutant to replicate within non-phagocytic cells, such as fibroblasts, without causing damage, could be a potential advantage for a live attenuated vaccine against tuberculosis...
  19. pmc Novel streptomycin resistance gene from Mycobacterium fortuitum
    Santiago Ramón-García
    Departamento de Microbiologia, Medicina Preventiva y Salud Pública, Facultad de Medicina, Universidad de Zaragoza, C Domingo Miral s n, 50009 Zaragoza, Spain
    Antimicrob Agents Chemother 50:3920-2. 2006
    ..APH(3")-Ic phosphorylates and inactivates streptomycin. Similar genes have been described in Streptomyces griseus and plasmid RSF1010. It is also present in some M. fortuitum clinical isolates...
  20. pmc Rapid test for identification of a highly transmissible Mycobacterium tuberculosis Beijing strain of sub-Saharan origin
    María Isabel Millán-Lou
    IIS Aragón, Hospital Universitario Miguel Servet, Zaragoza, Spain
    J Clin Microbiol 50:516-8. 2012
    ..A rapid test that detects IS6110 present between dnaA and dnaN in the Beijing strains and in a specific site for GC1237 (Rv2180c) has been developed. This test would be a useful tool in the surveillance of subsequent cases...
  21. doi request reprint Deciphering the role of IS6110 in a highly transmissible Mycobacterium tuberculosis Beijing strain, GC1237
    Henar Alonso
    Grupo de Genética de Micobacterias, Departamento de Microbiologia, Medicina Preventiva y Salud Pública, Universidad de Zaragoza, Spain
    Tuberculosis (Edinb) 91:117-26. 2011
    ....
  22. pmc Unsuspected and extensive transmission of a drug-susceptible Mycobacterium tuberculosis strain
    Ana Isabel López-Calleja
    Servicio de Microbiologia, Hospital Universitario Miguel Servet, Paseo Isabel la católica, Zaragoza, Spain
    BMC Pulm Med 9:3. 2009
    ..A large and unsuspected tuberculosis outbreak involving 18.7% of the total of the tuberculosis cases studied, was detected in a population-based molecular epidemiological study performed in Zaragoza (Spain) from 2001 to 2004...
  23. pmc Attenuated Mycobacterium tuberculosis SO2 vaccine candidate is unable to induce cell death
    Adriana Aporta
    Grupo Apoptosis, Inmunidad y Cáncer, Dpto Bioquímica y Biología Molecular y Celular, Fac Ciencias, Universidad de Zaragoza, Zaragoza, Spain
    PLoS ONE 7:e45213. 2012
    ..tuberculosis infection...
  24. ncbi request reprint Evolutionary history of tuberculosis shaped by conserved mutations in the PhoPR virulence regulator
    Jesús Gonzalo-Asensio
    Grupo de Genética de Micobacterias, Facultad de Medicina, Universidad de Zaragoza, 50009 Zaragoza, Spain Centro de Investigación Biomédica en Red de Enfermedades Respiratorias, Instituto de Salud Carlos III, 28029 Madrid, Spain
    Proc Natl Acad Sci U S A 111:11491-6. 2014
    ..Our findings ultimately explain the long-term epidemiological data, suggesting that M. bovis and related phoPR-mutated strains pose a lower risk for progression to overt human TB, with major impact on the evolutionary history of TB. ..
  25. pmc ESX-1-induced apoptosis during mycobacterial infection: to be or not to be, that is the question
    Nacho Aguilo
    Grupo de Genética de Micobacterias, Department of Microbiologia, Medicina Preventiva y Salud Pública, Universidad de Zaragoza Zaragoza, Spain CIBER Enfermedades Respiratorias, Instituto de Salud Carlos III Madrid, Spain
    Front Cell Infect Microbiol 3:88. 2013
    ..In this review, we summarize the evidences that support the involvement of ESX-1-induced apoptosis in virulence, intending to provide a rational treatise for the role of programmed cell death during M. tuberculosis infection. ..
  26. ncbi request reprint A Specific Polymorphism in Mycobacterium tuberculosis H37Rv Causes Differential ESAT-6 Expression and Identifies WhiB6 as a Novel ESX-1 Component
    Luis Solans
    Grupo de Genética de Micobacterias, Departamento de Microbiologia, Medicina Preventiva y Salud Pública, Facultad de Medicina, Universidad de Zaragoza, Zaragoza, Spain CIBER Enfermedades Respiratorias, Instituto de Salud Carlos III, Madrid, Spain
    Infect Immun 82:3446-56. 2014
    ....
  27. pmc Role of the Mycobacterium tuberculosis P55 efflux pump in intrinsic drug resistance, oxidative stress responses, and growth
    Santiago Ramón-García
    Departamento de Microbiologia, Medicina Preventiva y Salud Pública, Universidad de Zaragoza, Zaragoza 50009, Spain
    Antimicrob Agents Chemother 53:3675-82. 2009
    ..Inhibitors of the P55 efflux pump could help to improve current treatments for tuberculosis...
  28. ncbi request reprint ESX-1-induced apoptosis is involved in cell-to-cell spread of Mycobacterium tuberculosis
    J I Aguilo
    Grupo de Genética de Micobacterias, Dpto Microbiologia, Medicina Preventiva y Salud Pública, Universidad de Zaragoza, C Domingo Miral s n, 50009, Zaragoza, Spain CIBER Enfermedades Respiratorias, Instituto de Salud Carlos III, Madrid, Spain
    Cell Microbiol 15:1994-2005. 2013
    ..Our data further indicate that BCG and MTBVAC vaccines are inefficient in inducing apoptosis and colonizing new cells, correlating with the strong attenuation profile of these strains previously observed in vitro and in vivo...
  29. ncbi request reprint Recent developments in tuberculosis vaccines
    Dessislava Marinova
    Grupo de Genética de Micobacterias, Dpto Microbiologia, Medicina Preventiva y Salud Pública, Universidad de Zaragoza, C Domingo Miral s n, 50009 Zaragoza, Spain
    Expert Rev Vaccines 12:1431-48. 2013
    ..The challenge ahead is to optimize the planning for advanced clinical trials in poor endemic settings, which could be greatly facilitated by identifying correlates of protection. ..
  30. doi request reprint Mapping of IS6110 insertion sites in Mycobacterium bovis isolates in relation to adaptation from the animal to human host
    Isabel Otal
    Departamento de Microbiologia, Medicina Preventiva y Salud Pública, Universidad de Zaragoza, Zaragoza, Spain
    Vet Microbiol 129:333-41. 2008
    ..IS6110 was inserted in a position where it might serve as a promoter in two cases. We conclude that IS6110 transpositions in M. bovis may be a driving force in the adaptation from the animal to the human host...
  31. pmc Single nucleotide polymorphism (SNP) analysis used for the phylogeny of the Mycobacterium tuberculosis complex based on a pyrosequencing assay
    Adriana Cabal
    IIS Aragón, Hopsital Universitario Miguel Servet, Zaragoza, Spain
    BMC Microbiol 14:21. 2014
    ..We attempted to classify those strains that could not been categorized into lineages by the genotyping methods used in the routine testing...
  32. ncbi request reprint The virulence-associated two-component PhoP-PhoR system controls the biosynthesis of polyketide-derived lipids in Mycobacterium tuberculosis
    Jesús Gonzalo Asensio
    Departamento de Microbiologia, Medicina Preventiva y Salud Pública, Universidad de Zaragoza, C Domingo Miral sin numero, 50009 Zaragoza, Spain
    J Biol Chem 281:1313-6. 2006
    ..This work represents an important step toward the functional characterization of PhoP-PhoR and the understanding of complex lipid synthesis in M. tuberculosis...
  33. pmc Pulmonary Mycobacterium bovis BCG vaccination confers dose-dependent superior protection compared to that of subcutaneous vaccination
    Nacho Aguilo
    Grupo de Genética de Micobacterias, Departmento de Microbiologia, Medicina Preventiva y Salud Pública, Faculty of Medicine, Universidad de Zaragoza, Zaragoza, Spain
    Clin Vaccine Immunol 21:594-7. 2014
    ..Here, we show that pulmonary BCG vaccination of mice with a broad dose range provides superior protection against Mycobacterium tuberculosis challenge compared to that of subcutaneous vaccination. ..
  34. ncbi request reprint Transcriptional analysis of and resistance level conferred by the aminoglycoside acetyltransferase gene aac(2')-Id from Mycobacterium smegmatis
    Virginie Mick
    Departamento de Microbiologia, Medicina Preventiva y Salud Pública, Facultad de Medicina, Universidad de Zaragoza, C Domingo Miral s n, 50009 Zaragoza, Spain
    J Antimicrob Chemother 61:39-45. 2008
    ..To analyse the correlation between the expression levels of the aac(2')-Id gene from Mycobacterium smegmatis mc(2)155 and the resistance levels to aminoglycosides conferred by the encoded aminoglycoside 2'-N-acetyltransferase [AAC(2')-Id]...
  35. pmc The transcriptional regulatory network of Mycobacterium tuberculosis
    Joaquín Sanz
    Instituto de Biocomputación y Física de Sistemas Complejos, Universidad de Zaragoza, Zaragoza, Spain
    PLoS ONE 6:e22178. 2011
    ..tb is known...
  36. pmc The PhoP-dependent ncRNA Mcr7 modulates the TAT secretion system in Mycobacterium tuberculosis
    Luis Solans
    Grupo de Genética de Micobacterias, Facultad de Medicina, Universidad de Zaragoza, Zaragoza, Spain Ciber de Enfermedades Respiratorias, Instituto de Salud Carlos III, Madrid, Spain
    PLoS Pathog 10:e1004183. 2014
    ..Mcr7, the first ncRNA of M. tuberculosis whose function has been established, therefore represents a missing link between the PhoPR two-component system and the downstream functions necessary for successful infection of the host. ..
  37. ncbi request reprint Contribution of the Rv2333c efflux pump (the Stp protein) from Mycobacterium tuberculosis to intrinsic antibiotic resistance in Mycobacterium bovis BCG
    Santiago Ramón-García
    Departamento de Microbiologia, Medicina Preventiva y Salud Pública, Universidad de Zaragoza, 50009 Zaragoza, Spain
    J Antimicrob Chemother 59:544-7. 2007
    ..To characterize the efflux pump encoded by the gene Rv2333c from Mycobacterium tuberculosis, and assess its contribution to intrinsic antibiotic resistance using Mycobacterium bovis BCG as a model organism...