A Marti

Summary

Affiliation: University of Navarra
Country: Spain

Publications

  1. ncbi request reprint Methodological approaches to assess body-weight regulation and aetiology of obesity
    A Marti
    Department of Physiology and Nutrition, University of Navarra, Pamplona, Spain
    Proc Nutr Soc 59:405-11. 2000
  2. pmc Telomere length as a biomarker for adiposity changes after a multidisciplinary intervention in overweight/obese adolescents: the EVASYON study
    Sonia García-Calzón
    Department of Nutrition, Food Science and Physiology, University of Navarra, Pamplona, Spain
    PLoS ONE 9:e89828. 2014
  3. doi request reprint Differential DNA methylation patterns between high and low responders to a weight loss intervention in overweight or obese adolescents: the EVASYON study
    Adriana Moleres
    Department of Nutrition, Food Science, Physiology, and Toxicology, University of Navarra, Pamplona, Spain
    FASEB J 27:2504-12. 2013
  4. pmc Obesity induced by a pair-fed high fat sucrose diet: methylation and expression pattern of genes related to energy homeostasis
    Almudena Lomba
    Department of Nutrition and Food Sciences, Physiology and Toxicology, University of Navarra, Pamplona, Spain
    Lipids Health Dis 9:60. 2010
  5. pmc Design and evaluation of a treatment programme for Spanish adolescents with overweight and obesity. The EVASYON Study
    David Martinez-Gomez
    Department of Metabolism and Nutrition, Instituto del Frio, Institute of Food Science and Technology and Nutrition, Spanish National Research Council CSIC, Madrid, Spain
    BMC Public Health 9:414. 2009
  6. pmc Birth weight and blood lipid levels in Spanish adolescents: influence of selected APOE, APOC3 and PPARgamma2 gene polymorphisms. The AVENA Study
    Jonatan R Ruiz
    Department of Medical Physiology, School of Medicine, University of Granada, 18071 Granada, Spain
    BMC Med Genet 9:98. 2008
  7. ncbi request reprint Down-regulation of heart HFABP and UCP2 gene expression in diet-induced (cafeteria) obese rats
    A Marti
    Dpto de Fisiología y Nutrición, Universidad de Navarra, Pamplona, Spain
    J Physiol Biochem 58:69-74. 2002
  8. ncbi request reprint TRP64ARG polymorphism of the beta 3-adrenergic receptor gene and obesity risk: effect modification by a sedentary lifestyle
    A Marti
    Department of Physiology and Nutrition, University of Navarra, Pamplona, Spain
    Diabetes Obes Metab 4:428-30. 2002
  9. ncbi request reprint A novel nonsense mutation in the melanocortin-4 receptor associated with obesity in a Spanish population
    A Marti
    Department of Physiology and Nutrition, University of Navarra, Pamplona, Spain
    Int J Obes Relat Metab Disord 27:385-8. 2003
  10. doi request reprint Association between leptin receptor (LEPR) and brain-derived neurotrophic factor (BDNF) gene variants and obesity: a case-control study
    A Marti
    Department of Nutrition and Food Sciences, Physiology and Toxicology, University of Navarra, 31080 Pamplona, Navarra, Spain
    Nutr Neurosci 12:183-8. 2009

Collaborators

Detail Information

Publications72

  1. ncbi request reprint Methodological approaches to assess body-weight regulation and aetiology of obesity
    A Marti
    Department of Physiology and Nutrition, University of Navarra, Pamplona, Spain
    Proc Nutr Soc 59:405-11. 2000
    ....
  2. pmc Telomere length as a biomarker for adiposity changes after a multidisciplinary intervention in overweight/obese adolescents: the EVASYON study
    Sonia García-Calzón
    Department of Nutrition, Food Science and Physiology, University of Navarra, Pamplona, Spain
    PLoS ONE 9:e89828. 2014
    ..Telomeres are biomarkers of biological aging. Shorter telomeres have been associated with increased adiposity in adults. However, this relationship remains unclear in children and adolescents...
  3. doi request reprint Differential DNA methylation patterns between high and low responders to a weight loss intervention in overweight or obese adolescents: the EVASYON study
    Adriana Moleres
    Department of Nutrition, Food Science, Physiology, and Toxicology, University of Navarra, Pamplona, Spain
    FASEB J 27:2504-12. 2013
    ..In summary, we have identified 5 DNA regions that are differentially methylated depending on weight loss response. These methylation changes may help to better understand the weight loss response in obese adolescents...
  4. pmc Obesity induced by a pair-fed high fat sucrose diet: methylation and expression pattern of genes related to energy homeostasis
    Almudena Lomba
    Department of Nutrition and Food Sciences, Physiology and Toxicology, University of Navarra, Pamplona, Spain
    Lipids Health Dis 9:60. 2010
    ....
  5. pmc Design and evaluation of a treatment programme for Spanish adolescents with overweight and obesity. The EVASYON Study
    David Martinez-Gomez
    Department of Metabolism and Nutrition, Instituto del Frio, Institute of Food Science and Technology and Nutrition, Spanish National Research Council CSIC, Madrid, Spain
    BMC Public Health 9:414. 2009
    ....
  6. pmc Birth weight and blood lipid levels in Spanish adolescents: influence of selected APOE, APOC3 and PPARgamma2 gene polymorphisms. The AVENA Study
    Jonatan R Ruiz
    Department of Medical Physiology, School of Medicine, University of Granada, 18071 Granada, Spain
    BMC Med Genet 9:98. 2008
    ..5 years...
  7. ncbi request reprint Down-regulation of heart HFABP and UCP2 gene expression in diet-induced (cafeteria) obese rats
    A Marti
    Dpto de Fisiología y Nutrición, Universidad de Navarra, Pamplona, Spain
    J Physiol Biochem 58:69-74. 2002
    ..The down-regulation of heart HFABP and UCP2 parallels the lower lipid utilization which may account for an enhanced fat deposition. It is plausible that these two genes are regulated by the same family of transcription factors...
  8. ncbi request reprint TRP64ARG polymorphism of the beta 3-adrenergic receptor gene and obesity risk: effect modification by a sedentary lifestyle
    A Marti
    Department of Physiology and Nutrition, University of Navarra, Pamplona, Spain
    Diabetes Obes Metab 4:428-30. 2002
    ..We performed a case-control study to assess the association between obesity risk and the Trp64Arg polymorphism of the beta 3-adrenergic receptor gene...
  9. ncbi request reprint A novel nonsense mutation in the melanocortin-4 receptor associated with obesity in a Spanish population
    A Marti
    Department of Physiology and Nutrition, University of Navarra, Pamplona, Spain
    Int J Obes Relat Metab Disord 27:385-8. 2003
    ..Hence, MC4R is involved in the most common monogenic form of human obesity described so far...
  10. doi request reprint Association between leptin receptor (LEPR) and brain-derived neurotrophic factor (BDNF) gene variants and obesity: a case-control study
    A Marti
    Department of Nutrition and Food Sciences, Physiology and Toxicology, University of Navarra, 31080 Pamplona, Navarra, Spain
    Nutr Neurosci 12:183-8. 2009
    ..Human and animal studies provide evidence for a relevant role of the leptin receptor (LEPR) and the brain-derived neurotrophic factor (BDNF) genes in energy homeostasis...
  11. doi request reprint Interaction between genes and lifestyle factors on obesity
    Amelia Marti
    School of Pharmacy, University of Navarra, Pamplona, Spain
    Proc Nutr Soc 67:1-8. 2008
    ..Variants on other genes relating to appetite regulation such as melanocortin and leptin receptors have also been investigated. Examples of some recently-identified interactions are discussed...
  12. ncbi request reprint [Advances in molecular nutrition: nutrigenomics and/or nutrigenetics]
    A Marti
    Dpto de Fisiología y Nutrición, Universidad de Navarra, Pamplona, Navarra, Espana
    Nutr Hosp 20:157-64. 2005
    ..On the one hand, the study of the influence of nutrients on gene expression (nutrigenomics) and, on the other hand, to know the influence of genetic variations in the organism response to nutrients (nutrigenetics)...
  13. ncbi request reprint Higher obesity risk associated with the exon-8 insertion of the UCP2 gene in a Spanish case-control study
    Amelia Marti
    Department of Physiology and Nutrition, University of Navarra, and Hospital of Navarra, Pamplona, Spain
    Nutrition 20:498-501. 2004
    ..We conducted a case-control study to examine the association between the risk of obesity and the exon-8 insertion allele in the UCP2 gene...
  14. pmc Meta-analysis on the effect of the N363S polymorphism of the glucocorticoid receptor gene (GRL) on human obesity
    Amelia Marti
    Department of Physiology and Nutrition, University of Navarra, Pamplona, Spain
    BMC Med Genet 7:50. 2006
    ..Individual studies may lack statistical power which may result in disparate results. This limitation can be overcome using meta-analytic techniques...
  15. ncbi request reprint Time-dependent effects of a high-energy-yielding diet on the regulation of specific white adipose tissue genes
    J Margareto
    Department of Physiology and Nutrition, University of Navarra, Pamplona, 31008, Spain
    Biochem Biophys Res Commun 283:6-11. 2001
    ....
  16. ncbi request reprint Influence of two polymorphisms of the tumoral necrosis factor-alpha gene on the obesity phenotype
    M S Corbalán
    Department of Physiology and Nutrition, University of Navarra, Pamplona, Spain
    Diabetes Nutr Metab 17:17-22. 2004
    ....
  17. ncbi request reprint TV watching modifies obesity risk linked to the 27Glu polymorphism of the ADRB2 gene in girls
    M C Ochoa
    Department of Physiology and Nutrition, University of Navarra, Pamplona, Spain
    Int J Pediatr Obes 1:83-8. 2006
    ..A matched case-control study was conducted in a population of Spanish children and adolescents (5-18 years old), to assess the interaction between the Gln27Glu polymorphism of the ADRB2 and television (TV) watching on obesity risk...
  18. ncbi request reprint Up-regulation of a thermogenesis-related gene (UCP1) and down-regulation of PPARgamma and aP2 genes in adipose tissue: possible features of the antiobesity effects of a beta3-adrenergic agonist
    J Margareto
    Department of Physiology and Nutrition, University of Navarra, Pamplona, Spain
    Biochem Pharmacol 61:1471-8. 2001
    ....
  19. ncbi request reprint Serum and gene expression levels of leptin and adiponectin in rats susceptible or resistant to diet-induced obesity
    N Pérez-Echarri
    Department of Physiology and Nutrition, University of Navarra, 31008 Pamplona, Spain
    J Physiol Biochem 61:333-42. 2005
    ..However, neither changes in leptin or adiponectin seem to be involved in the adaptive mechanisms that confer resistance to high fat intake...
  20. ncbi request reprint High-fat feeding period affects gene expression in rat white adipose tissue
    I P Lopez
    Department of Biochemistry and Molecular Biology, University of Navarra, Spain
    Mol Cell Biochem 275:109-15. 2005
    ....
  21. ncbi request reprint A maximal effort trial in obese women carrying the beta2-adrenoceptor Gln27Glu polymorphism
    T Macho-Azcarate
    Dept of Physiology and Nutrition, University Clinic, University of Navarra, Pamplona, Spain
    J Physiol Biochem 58:103-8. 2002
    ..These results provide evidence about a possible impact of the Gln27Glu polymorphism in the ADRB2 gene concerning a better response to exercise in obese Gln27 female subjects, in which basal insulinemia may play a role...
  22. ncbi request reprint Effects of a beta3-adrenergic agonist on the immune response in diet-induced (cafeteria) obese animals
    O Lamas
    Dept of Physiology and Nutrition, University of Navarra, 31008 Pamplona, Spain
    J Physiol Biochem 59:183-91. 2003
    ..Summing up, at the immune system level, trecadrine administration increased the proportion of CD4+ spleen lymphocytes, although it was not able to restore the lymphocyte proliferative response which was depressed...
  23. ncbi request reprint Conjugated linoleic acid inhibits glucose metabolism, leptin and adiponectin secretion in primary cultured rat adipocytes
    P Pérez-Matute
    Department of Physiology and Nutrition, University of Navarra, 31008 Pamplona, Spain
    Mol Cell Endocrinol 268:50-8. 2007
    ..Furthermore, the inhibition of leptin and adiponectin production induced by CLA may contribute to insulin resistance observed in CLA-treated animals and humans...
  24. ncbi request reprint Basal fat oxidation and after a peak oxygen consumption test in obese women with a beta2 adrenoceptor gene polymorphism
    T Macho-Azcarate
    Department of Physiology and Nutrition, University of Navarra, Pamplona, Spain
    J Nutr Biochem 14:275-9. 2003
    ....
  25. doi request reprint A 3-year Mediterranean-style dietary intervention may modulate the association between adiponectin gene variants and body weight change
    C Razquin
    Department of Nutrition and Food Sciences, Physiology and Toxicology, University of Navarra, Irunlarrea 1, 31080, Pamplona, Navarra, Spain
    Eur J Nutr 49:311-9. 2010
    ....
  26. ncbi request reprint G allele of the -930A>G polymorphism of the CYBA gene is associated with insulin resistance in obese subjects
    M C Ochoa
    Department of Nutrition, Food Science, Physiology and Toxicology, University of Navarra, Pamplona, Spain
    J Physiol Biochem 64:127-33. 2008
    ..In conclusion, a protective effect in carriers of the -930A/G polymorphism of the p22phox gene against insulin resistance in a population of Spanish obese adults has been found...
  27. ncbi request reprint A novel mutation Thr162Arg of the melanocortin 4 receptor gene in a Spanish children and adolescent population
    M C Ochoa
    Department of Physiology and Nutrition, University Clinic, University of Navarra, Pamplona Navarra, Spain
    Clin Endocrinol (Oxf) 66:652-8. 2007
    ..In addition, functional assays were performed for a novel MC4R mutation...
  28. ncbi request reprint UCP2 muscle gene transfer modifies mitochondrial membrane potential
    A Marti
    Department of Physiology and Nutrition, University of Navarra, Pamplona, Spain
    Int J Obes Relat Metab Disord 25:68-74. 2001
    ..Our results suggest the potential involvement of UCP2 in uncoupling respiration. International Journal of Obesity (2001) 25, 68-74..
  29. ncbi request reprint Changes in UCP2, PPARgamma2, and c/EBPalpha gene expression induced by a neuropeptide Y (NPY) related receptor antagonist in overweight rats
    J Margareto
    Department of Physiology and Nutrition, University of Navarra, Pamplona, Spain
    Nutr Neurosci 5:13-7. 2002
    ..A.0204 may regulate body fat deposition by affecting both energy dissipation and white adipose tissue deposition, representing a potential new pharmacological strategy for obesity management...
  30. ncbi request reprint The risk of obesity and the Trp64Arg polymorphism of the beta(3)-adrenergic receptor: effect modification by age
    M S Corbalán
    Department of Physiology and Nutrition, University of Navarra, Pamplona, Spain
    Ann Nutr Metab 46:152-8. 2002
    ..To examine the association between the risk of obesity and the Trp64Arg polymorphism of the beta(3)-adrenergic receptor gene...
  31. doi request reprint Il6 gene promoter polymorphism (-174G/C) influences the association between fat mass and cardiovascular risk factors
    A Moleres
    Dept of Nutrition and Food Sciences, Physiology and Toxicology, Univ of Navarra, Spain
    J Physiol Biochem 65:405-13. 2009
    ..Our results suggest that this promoter polymorphism influences the association between adiposity and some plasma markers...
  32. ncbi request reprint Gene-gene interaction between PPAR gamma 2 and ADR beta 3 increases obesity risk in children and adolescents
    M C Ochoa
    Department of Physiology and Nutrition, University of Navarra, 31080 Pamplona, Spain
    Int J Obes Relat Metab Disord 28:S37-41. 2004
    ..Our aim was to explore the synergistic contribution of the two polymorphisms: Pro12Ala of the PPAR gamma 2 gene and Trp64Arg of the ADR beta 3 gene to obesity risk in a Spanish children and adolescent population...
  33. ncbi request reprint No evidence of association between the serotonin 2A receptor--1438G/A promoter polymorphism and childhood obesity in a Spanish population: A case-parent study and a matched case-control study
    J L Santos
    Department of Physiology and Nutrition, University of Navarra, 31080, Pamplona, Spain
    Nutr Neurosci 8:207-11. 2005
    ..Likewise, no association is suggested by the case-parent study. In conclusion, it is unlikely that the--1438 G/A polymorphism of 5HT2A gene may influence obesity in a Spanish children population...
  34. doi request reprint A 3 years follow-up of a Mediterranean diet rich in virgin olive oil is associated with high plasma antioxidant capacity and reduced body weight gain
    C Razquin
    Department of Nutrition and Food Sciences, Physiology and Toxicology, University of Navarra, Navarra, Spain
    Eur J Clin Nutr 63:1387-93. 2009
    ....
  35. ncbi request reprint NF-kappa B-binding activity in an animal diet-induced overweightness model and the impact of subsequent energy restriction
    O Lamas
    Department of Physiology and Nutrition, University of Navarra, 31008 Pamplona, Navarre, Spain
    Biochem Biophys Res Commun 311:533-9. 2003
    ..These results suggest that PPAR gamma 1 may be involved in the altered immune response through changes in the activity of NF-kappa B...
  36. doi request reprint A 3-year intervention with a Mediterranean diet modified the association between the rs9939609 gene variant in FTO and body weight changes
    C Razquin
    Department of Nutrition and Food Sciences, Physiology and Toxicology, University of Navarra, Navarra, Spain
    Int J Obes (Lond) 34:266-72. 2010
    ....
  37. ncbi request reprint [Influence of the -866G/A polymorphism of the UCP2 gene on an obese pediatric population]
    R Zurbano
    Departamento de Fisiología y Nutrición, Universidad de Navarra, Pamplona, Espana
    Nutr Hosp 21:52-6. 2006
    ..According to several studies, the -866G allele is related to an increased risk of developing obesity, although the results are contradictory about this association in the literature...
  38. ncbi request reprint Gene expression changes in rat white adipose tissue after a high-fat diet determined by differential display
    I P Lopez
    Department of Biochemistry and Molecular Biology, University of Navarra, 31080 Pamplona, Navarra, Spain
    Biochem Biophys Res Commun 318:234-9. 2004
    ....
  39. ncbi request reprint CHO intake alters obesity risk associated with Pro12Ala polymorphism of PPARgamma gene
    A Marti
    University of Navarra, Department of Physiology and Nutrition, Pamplona, Spain
    J Physiol Biochem 58:219-20. 2002
  40. ncbi request reprint Decreased splenic mRNA expression levels of TNF-alpha and IL-6 in diet-induced obese animals
    O Lamas
    Department of Physiology and Nutrition, University of Navarra, C Irunlarrea, 1, 31008, Pamplona, Spain
    J Physiol Biochem 60:279-83. 2004
    ..806, p = 0.000). These findings support the hypothesis that TNF-alpha gene expression may follow different trends in obese animals adipocytes and splenocytes...
  41. ncbi request reprint Beta(2)-adrenergic receptor mutation and abdominal obesity risk: effect modification by gender and HDL-cholesterol
    M S Corbalán
    Department of Physiology and Nutrition, University of Navarra, 31080 Pamplona Spain
    Eur J Nutr 41:114-8. 2002
    ..A case-control study was conducted to examine the association between the 27Glu polymorphism of the beta(2)-adrenergic receptor gene (ADRB2) and the risk of abdominal obesity (defined by a waist/hip ratio: WHR higher than 0.85)...
  42. ncbi request reprint Linoleic acid decreases leptin and adiponectin secretion from primary rat adipocytes in the presence of insulin
    P Pérez-Matute
    Department of Physiology and Nutrition, University of Navarra, 31008, Pamplona, Navarra, Spain
    Lipids 42:913-20. 2007
    ....
  43. doi request reprint Pro12Ala variant of the PPARG2 gene increases body mass index: An updated meta-analysis encompassing 49,092 subjects
    C Galbete
    Department of Nutrition, Food Science, Physiology and Toxicology, University of Navarra, Pamplona, Spain
    Obesity (Silver Spring) 21:1486-95. 2013
    ..In this meta-analysis, the effects of Pro12Ala polymorphism of the PPARG2 gene on BMI were investigated...
  44. ncbi request reprint Effects of eicosapentaenoic acid (EPA) on adiponectin gene expression and secretion in primary cultured rat adipocytes
    S Lorente-Cebrián
    Department of Physiology and Nutrition, University of Navarra, 31008 Pamplona, Spain
    J Physiol Biochem 62:61-9. 2006
    ..Moreover, these results suggest that other mechanisms different from the direct stimulation of adiponectin by the fatty acid are underlying the insulin-sensitizing properties observed after EPA treatment in vivo...
  45. ncbi request reprint [Inflammatory biomarkers: the link between obesity and associated pathologies]
    Ma A Zulet
    Departamento de Ciencias de la Alimentación, Fisiología y Toxicología, Universidad de Navarra, Pamplona, Espana
    Nutr Hosp 22:511-27. 2007
    ..However, it is currently unclear the role of many of them concerning inflammatory processes in humans, as well as the factors involved in their regulation...
  46. ncbi request reprint Does weight loss prognosis depend on genetic make-up?
    M J Moreno-Aliaga
    Department of Physiology and Nutrition, University of Navarra, 31008 Pamplona, Spain
    Obes Rev 6:155-68. 2005
    ....
  47. ncbi request reprint Genes, lifestyles and obesity
    A Marti
    Department of Physiology and Nutrition, University of Navarra, Pamplona, Spain
    Int J Obes Relat Metab Disord 28:S29-36. 2004
    ..To review the role of genes and lifestyle factors, particularly dietary habits and physical activity patterns, in obesity risk as well as their potential interactions...
  48. ncbi request reprint Modification of RXRalpha expression according to the duration of a cafeteria diet
    J Margareto
    Department of Physiology and Nutrition, University of Navarra, Pamplona, Spain
    J Physiol Biochem 57:347-8. 2001
  49. ncbi request reprint Effects of arachidonic acid on leptin secretion and expression in primary cultured rat adipocytes
    P Pérez-Matute
    Department of Physiology and Nutrition, University of Navarra, 31008 Pamplona, Spain
    J Physiol Biochem 59:201-8. 2003
    ..These results suggest that the inhibitory effect of the arachidonic acid on leptin secretion and expression may be due, al least in part, to the increase in the anaerobic utilization of glucose...
  50. ncbi request reprint Gln27Glu polymorphism in the beta2 adrenergic receptor gene and lipid metabolism during exercise in obese women
    T Macho-Azcarate
    Department of Physiology and Nutrition, University of Navarra, Pamplona, Spain
    Int J Obes Relat Metab Disord 26:1434-41. 2002
    ..In our population, we previously found an association of higher body mass index (BMI) among women who reported more physical activity and carried the Glu27 allele as compared to non carriers with the same level of activity...
  51. ncbi request reprint Total antioxidant capacity and oxidative stress after a 10-week dietary intervention program in obese children
    T Rendo-Urteaga
    Department of Nutrition, Food Science and Physiology, University of Navarra, C Irunlarrea s n, CP31008, Pamplona, Navarra, Spain
    Eur J Pediatr 173:609-16. 2014
    ..Moreover, after the intervention changes in dietary TAC and WL were significantly associated. Our result suggests that specific food with a high TAC content (such as fruits, vegetables, and legumes) could be recommended to improve WL. ..
  52. ncbi request reprint Obesity and immune function relationships
    A Marti
    Department of Physiology and Nutrition, University of Navarra, C Irunlarrea s n 31080 Pamplona, Navarra, Spain
    Obes Rev 2:131-40. 2001
    ..In this context, more research is needed to clarify the clinical implications of the alterations induced by obesity on the immune function...
  53. doi request reprint Design of the nutritional therapy for overweight and obese Spanish adolescents conducted by registered dieticians: the EVASYON study
    Ma Marqués
    Department of Preventive Medicine and Public Health, University of Navarra, Pamplona, Spain
    Nutr Hosp 27:165-76. 2012
    ....
  54. doi request reprint Egg consumption and risk of cardiovascular disease in the SUN Project
    I Zazpe
    Department of Nutrition and Food Sciences, Physiology and Toxicology, University of Navarra, Spain
    Eur J Clin Nutr 65:676-82. 2011
    ..Our aim was to examine the association between egg consumption and incidence of CVD in a prospective dynamic Mediterranean cohort of 14,185 university graduates...
  55. ncbi request reprint Genetics of obesity: gene x nutrient interactions
    A Marti
    Department of Physiology and Nutrition, University of Navarra, 31008 Pamplona, Spain
    Int J Vitam Nutr Res 76:184-93. 2006
    ....
  56. ncbi request reprint Obesity and immunocompetence
    O Lamas
    Department of Physiology and Nutrition, University of Navarra, Pamplona, Spain
    Eur J Clin Nutr 56:S42-5. 2002
    ..Additional research is needed to determine the clinical implications of these alterations on immunity and whether various interventions such as weight loss, exercise or nutrient supplementation could help to ameliorate them...
  57. doi request reprint Longitudinal association of telomere length and obesity indices in an intervention study with a Mediterranean diet: the PREDIMED-NAVARRA trial
    S García-Calzón
    Department of Nutrition, Food Science and Physiology, University of Navarra, Pamplona, Spain
    Int J Obes (Lond) 38:177-82. 2014
    ..Shorter telomere length (TL) is associated with some age-related human disorders, but its relationship with obesity or adiposity parameters remains unclear...
  58. ncbi request reprint Inflammation and conjugated linoleic acid: mechanisms of action and implications for human health
    M A Zulet
    Departamento de Fisiología y Nutrición, Facultad de Farmacia, Universidad de Navarra, Pamplona, Spain
    J Physiol Biochem 61:483-94. 2005
    ..Because inflammatory responses are associated with the pathophysiology of many diseases, including obesity and the metabolic syndrome, the investigation in this area is of growing interest in recent years...
  59. ncbi request reprint Mediterranean diet and stroke: objectives and design of the SUN project. Seguimiento Universidad de Navarra
    M A Martinez-Gonzalez
    Unidad de Epidemiologia y Salud Pública de la Universidad de Navarra, Irunlarrea, Pamplona, Spain
    Nutr Neurosci 5:65-73. 2002
    ..Thus, an epidemiological study in a Mediterranean country, such as Spain, focused on diet may offer new insights of the potential benefits of this nutritional pattern to prevent the onset of cerebrovascular diseases...
  60. ncbi request reprint Leptin gene transfer into muscle increases lipolysis and oxygen consumption in white fat tissue in ob/ob mice
    A Marti
    Department of Physiology and Nutrition, University of Navarra, Pamplona, Spain
    Biochem Biophys Res Commun 246:859-62. 1998
    ....
  61. ncbi request reprint Effects of a beta3-adrenergic agonist on glucose uptake and leptin expression and secretion in cultured adipocytes from lean and overweight (cafeteria) rats
    Maria J Moreno-Aliaga
    Department of Physiology and Nutrition, University of Navarra, 31008 Pamplona, Spain
    Biochem Biophys Res Commun 291:1201-7. 2002
    ..However, neither the cafeteria diet nor the Trecadrine treatment significantly alters the ability of adipocytes to increase leptin secretion in response to insulin...
  62. ncbi request reprint UCP1 muscle gene transfer and mitochondrial proton leak mediated thermogenesis
    Eider Larrarte
    Department of Physiology and Nutrition, University of Navarra, 31008 Pamplona, Spain
    Arch Biochem Biophys 404:166-71. 2002
    ..Our results revealed that UCP1 muscle gene transfer is associated with an induced mitochondrial proton leak, which could contribute to increase energy expenditure...
  63. ncbi request reprint Energy restriction restores the impaired immune response in overweight (cafeteria) rats
    Oscar Lamas
    Department of Physiology and Nutrition, University of Navarra, 31008 Pamplona, Spain
    J Nutr Biochem 15:418-25. 2004
    ..These results suggest that energy restriction is able to restore, at least in part, the impaired immune response commonly observed in overweight animals...
  64. ncbi request reprint Predictor factors for childhood obesity in a Spanish case-control study
    Maria C Ochoa
    Department of Physiology and Nutrition, University of Navarra, Pamplona, Spain
    Nutrition 23:379-84. 2007
    ....
  65. ncbi request reprint Effect of the Ala12 allele in the PPARgamma-2 gene on the relationship between birth weight and body composition in adolescents: the AVENA study
    Idoia Labayen
    Department of Nutrition and Food Science, University of the Basque Country, 01006 Vitoria, Spain
    Pediatr Res 62:615-9. 2007
    ..01), and this relationship remained significant after controlling for confounding variables (p < 0.05). Small body weight at birth may program lower FFM in adolescents carrying the Ala12 allele in the PPARgamma-2 gene...
  66. ncbi request reprint Association between obesity and insulin resistance with UCP2-UCP3 gene variants in Spanish children and adolescents
    Maria C Ochoa
    Department of Nutrition and Food Sciences, Physiology and Toxicology, C Irunlarrea s n, University of Navarra, 31080 Pamplona, Spain
    Mol Genet Metab 92:351-8. 2007
    ..Thus, the (-866A; rs659366)-(Ins; 45bp)-(-55C; rs1800849) haplotype may protect against insulin resistance in the obese population group...
  67. ncbi request reprint Obesity risk is associated with carbohydrate intake in women carrying the Gln27Glu beta2-adrenoceptor polymorphism
    J Alfredo Martinez
    Department of Physiology and Nutrition, University of Navarra, 31008 Pamplona, Spain
    J Nutr 133:2549-54. 2003
    ..01). This gene-nutrient interaction emphasizes the importance of examining the outcome of some obesity-related mutations depending on lifestyle (including diet) and may explain the heterogeneity of findings from previous studies...
  68. ncbi request reprint Eicosapentaenoic fatty acid increases leptin secretion from primary cultured rat adipocytes: role of glucose metabolism
    Patricia Pérez-Matute
    Department of Physiology and Nutrition, University of Navarra, 31008 Pamplona, Spain
    Am J Physiol Regul Integr Comp Physiol 288:R1682-8. 2005
    ..84, P < 0.01). Together, the results suggest that EPA, like insulin, stimulates leptin production by increasing the nonanaerobic/oxidative metabolism of glucose...
  69. ncbi request reprint Genotype-dependent response to energy-restricted diets in obese subjects: towards personalized nutrition
    J Alfredo Martinez
    University of Navarra, Department of Nutrition and Food Sciences, Physiology and Toxicology, C Irunlarrea, Pamplona 31008, Spain
    Asia Pac J Clin Nutr 17:119-22. 2008
    ..Therefore, this review shows preliminary evidence from human studies that support the existence of a genetic component in the fat reduction process associated to a negative energy balance...
  70. ncbi request reprint Mediterranean diet and reduction in the risk of a first acute myocardial infarction: an operational healthy dietary score
    Miguel A Martinez-Gonzalez
    Epidemiologia y Salud Publica, Facultad de Medicina, Universidad de Navarra, Irunlarrea 1, 31080 Pamplona, Spain
    Eur J Nutr 41:153-60. 2002
    ....
  71. ncbi request reprint Eicosapentaenoic acid actions on adiposity and insulin resistance in control and high-fat-fed rats: role of apoptosis, adiponectin and tumour necrosis factor-alpha
    Patricia Pérez-Matute
    Department of Physiology and Nutrition, University of Navarra, 31008 Pamplona, Spain
    Br J Nutr 97:389-98. 2007
    ..Adiposity-corrected adiponectin plasma levels were increased by EPA. These actions on both TNFalpha and adiponectin could explain the beneficial effects of EPA on insulin resistance induced by the cafeteria diet...
  72. ncbi request reprint DNA microarray analysis of genes differentially expressed in diet-induced (cafeteria) obese rats
    Iciar P López
    Department of Biochemistry, University of Navarro, 31080 Pamplona, Navarra, Spain
    Obes Res 11:188-94. 2003
    ..To better understand the molecular basis of dietary obesity, we examined adipose tissue genes differentially expressed in an obesity model using DNA microarray analysis...