Isidro Machado


Affiliation: University of Valencia
Country: Spain


  1. Machado I, Cruz J, Lavernia J, Rubio L, Campos J, Barrios M, et al. Superficial EWSR1-negative undifferentiated small round cell sarcoma with CIC/DUX4 gene fusion: a new variant of Ewing-like tumors with locoregional lymph node metastasis. Virchows Arch. 2013;463:837-42 pubmed publisher
  2. Machado I, Valera Alberni M, Martínez de Juan F, López Guerrero J, García Fadrique A, Cruz J, et al. [Histological factors predicting loco-regional lymph node metastasis in early invasive colorectal adenocarcinoma pT1]. Gastroenterol Hepatol. 2016;39:1-8 pubmed publisher
    ..We confirm that ALI and the presence of poorly differentiated cluster are frequently associated with N+ in early colorectal cancer. Consequently, these parameters should be routinely evaluated by pathologists. ..
  3. Machado I, Yoshida A, Morales M, Abrahão Machado L, Navarro S, Cruz J, et al. Review with novel markers facilitates precise categorization of 41 cases of diagnostically challenging, "undifferentiated small round cell tumors". A clinicopathologic, immunophenotypic and molecular analysis. Ann Diagn Pathol. 2018;34:1-12 pubmed publisher
    ..Any molecular findings should always be interpreted in relation to the specific clinical and pathological context. ..
  4. Machado I, Chong A, Serrano A, Naranjo Ugalde A, Pineda D, Savón L, et al. Epithelioid Hemangioma (Angiolymphoid Hyperplasia With Eosinophilia) of the Heart With Peripheral Eosinophilia and Nephrotic Syndrome. Int J Surg Pathol. 2016;24:59-65 pubmed publisher
    ..EH and Kimura disease represent separate entities, but clinical and/or histological overlapping can be observed. Epithelioid/histiocytoid endothelial cells constitute the hallmark feature that favors a final diagnosis of EH. ..
  5. Tardío J, Machado I, Navarro L, Idrovo F, Sanz Ortega J, Pellín A, et al. Ewing-like sarcoma with CIC-DUX4 gene fusion in a patient with neurofibromatosis type 1. A hitherto unreported association. Pathol Res Pract. 2015;211:877-82 pubmed publisher
  6. Machado I, Cruz J, Lavernia J, Llombart Bosch A. Solitary, multiple, benign, atypical, or malignant: the "Granular Cell Tumor" puzzle. Virchows Arch. 2016;468:527-38 pubmed publisher
    ..GCT with various unfavorable histological features might be labeled as "GCT with increased risk of metastasis" rather than malignant GCT. ..
  7. Machado I, Arana E, Cruz J, Brotons S, Vendrell J, Escriba I, et al. Malignant Peripheral Nerve Sheath Tumor With Osseous Heterologous Differentiation in Uncommon Locations (Heart and Retropharynx). Int J Surg Pathol. 2016;24:456-62 pubmed publisher
    ..Thus, it is important to rule out other histologically similar tumors, particularly in cases arising in uncommon locations or tumors with divergent heterologous differentiation. ..
  8. Machado I, Navarro L, Pellin A, Navarro S, Agaimy A, Tardio J, et al. Defining Ewing and Ewing-like small round cell tumors (SRCT): The need for molecular techniques in their categorization and differential diagnosis. A study of 200 cases. Ann Diagn Pathol. 2016;22:25-32 pubmed publisher
    ..Adopting appropriate tissue fixation and processing protocols is important to avoid degradation of fixed/embedded tissue when no frozen tumor is available. ..
  9. Machado I, Navarro S, Llombart Bosch A. Ewing sarcoma and the new emerging Ewing-like sarcomas: (CIC and BCOR-rearranged-sarcomas). A systematic review. Histol Histopathol. 2016;31:1169-81 pubmed publisher
    ..We review the clinical, histological, phenotypic and molecular findings of ESFT and these new emerging ELS. ..

More Information


  1. Machado I, Navarro S, Picci P, Llombart Bosch A. The utility of SATB2 immunohistochemical expression in distinguishing between osteosarcomas and their malignant bone tumor mimickers, such as Ewing sarcomas and chondrosarcomas. Pathol Res Pract. 2016;212:811-6 pubmed publisher
  2. Machado I, Lopez Guerrero J, Scotlandi K, Picci P, Llombart Bosch A. Immunohistochemical analysis and prognostic significance of PD-L1, PD-1, and CD8+ tumor-infiltrating lymphocytes in Ewing's sarcoma family of tumors (ESFT). Virchows Arch. 2018;472:815-824 pubmed publisher
    ..PD-1 was expressed in 26% of ESFT tumor cells and may have prognostic and therapeutic implications. CD8 expression in tumor-infiltrating lymphocytes was not related to prognosis. ..
  3. Machado I, Yoshida A, Lopez Guerrero J, Nieto M, Navarro S, Picci P, et al. Immunohistochemical analysis of NKX2.2, ETV4, and BCOR in a large series of genetically confirmed Ewing sarcoma family of tumors. Pathol Res Pract. 2017;213:1048-1053 pubmed publisher
    ..So far no antibody is entirely specific for ESFT diagnosis, and the IHC or molecular results in round cell tumors of bone may be strongly influenced by decalcification processes. ..
  4. Machado I, Pozo J, Marcilla D, Cruz J, Tardio J, Astudillo A, et al. [Protocol for the study of bone tumours and standardization of pathology reports]. Rev Esp Patol. 2017;50:34-44 pubmed publisher
    ..We include specific recommendations for the pre-analytical, analytical, and post-analytical phases, as well as protocols for gross and microscopic pathology. ..
  5. van Oosterwijk J, de Jong D, van Ruler M, Hogendoorn P, Dijkstra P, van Rijswijk C, et al. Three new chondrosarcoma cell lines: one grade III conventional central chondrosarcoma and two dedifferentiated chondrosarcomas of bone. BMC Cancer. 2012;12:375 pubmed publisher
    ..In pre-clinical research aiming at the identification of novel treatment targets, the need for representative cell lines and model systems is high, but availability is scarce...