Affiliation: University of Valencia
- Machado I, Lopez Guerrero J, Scotlandi K, Picci P, Llombart Bosch A. Immunohistochemical analysis and prognostic significance of PD-L1, PD-1, and CD8+ tumor-infiltrating lymphocytes in Ewing's sarcoma family of tumors (ESFT). Virchows Arch. 2018;472:815-824 pubmed publisher..PD-1 was expressed in 26% of ESFT tumor cells and may have prognostic and therapeutic implications. CD8 expression in tumor-infiltrating lymphocytes was not related to prognosis. ..
- Machado I, Yoshida A, Lopez Guerrero J, Nieto M, Navarro S, Picci P, et al. Immunohistochemical analysis of NKX2.2, ETV4, and BCOR in a large series of genetically confirmed Ewing sarcoma family of tumors. Pathol Res Pract. 2017;213:1048-1053 pubmed publisher..So far no antibody is entirely specific for ESFT diagnosis, and the IHC or molecular results in round cell tumors of bone may be strongly influenced by decalcification processes. ..
- Machado I, Pozo J, Marcilla D, Cruz J, Tardio J, Astudillo A, et al. [Protocol for the study of bone tumours and standardization of pathology reports]. Rev Esp Patol. 2017;50:34-44 pubmed publisher..We include specific recommendations for the pre-analytical, analytical, and post-analytical phases, as well as protocols for gross and microscopic pathology. ..
- van Oosterwijk J, de Jong D, van Ruler M, Hogendoorn P, Dijkstra P, van Rijswijk C, et al. Three new chondrosarcoma cell lines: one grade III conventional central chondrosarcoma and two dedifferentiated chondrosarcomas of bone. BMC Cancer. 2012;12:375 pubmed publisher..In pre-clinical research aiming at the identification of novel treatment targets, the need for representative cell lines and model systems is high, but availability is scarce...