Adela López de Ceráin
Affiliation: University of Navarra
Vettorazzi A, Pastor L, Guruceaga E, López de Ceráin A. Sex-dependent gene expression after ochratoxin A insult in F344 rat kidney. Food Chem Toxicol. 2018;123:337-348 pubmed publisher
..No biologically relevant changes were observed in the methylation of selected genes. ..
Corcuera L, Vettorazzi A, Arbillaga L, PÃ©rez N, Gil A, Azqueta A, et al
. Genotoxicity of Aflatoxin B1 and Ochratoxin A after simultaneous application of the in vivo micronucleus and comet assay. Food Chem Toxicol. 2015;76:116-24 pubmed publisher
..The combined treatment reduced DNA damage in the liver and had no influence in the kidney. Altogether, these results may be indicative of an antagonistic relationship regarding the genotoxicity of both mycotoxins. ..
IbÃ¡Ã±ez Vea M, GonzÃ¡lez PeÃ±as E, Lizarraga E, LÃ³pez de Cerain A. Co-occurrence of aflatoxins, ochratoxin A and zearalenone in barley from a northern region of Spain. Food Chem. 2012;132:35-42 pubmed publisher
..However, the co-occurrence of several mycotoxins, and therefore synergic or additive effects, should be taken into account when determining permitted levels or risk assessment. ..
Ojer P, Iglesias T, Azqueta A, Irache J, LÃ³pez de Cerain A. Toxicity evaluation of nanocarriers for the oral delivery of macromolecular drugs. Eur J Pharm Biopharm. 2015;97:206-17 pubmed publisher
Enciso J, López de Ceráin A, Pastor L, Azqueta A, Vettorazzi A. Is oxidative stress involved in the sex-dependent response to ochratoxin A renal toxicity?. Food Chem Toxicol. 2018;116:379-387 pubmed publisher
Pastor L, Vettorazzi A, Campion J, Cordero P, López de Ceráin A. Gene expression kinetics of renal transporters induced by ochratoxin A in male and female F344 rats. Food Chem Toxicol. 2016;98:169-178 pubmed publisher
..Overall, basal sex differences in F344 rats and the specific sex-dependent response to OTA of Oat2 might contribute to high kidney damage in male rats. ..
Lopez de Cerain A, Marin A, Idoate M, Tuñón M, Bello J. Carbonyl reductase and NADPH cytochrome P450 reductase activities in human tumoral versus normal tissues. Eur J Cancer. 1999;35:320-4 pubmed
..Although some variation in P450R activity in tumoral versus normal tissues was found in the majority of the samples studied, no significant differences could be demonstrated. ..
Gil A, Irache J, Penuelas I, Gonzalez Navarro C, López de Ceráin A. Toxicity and biodistribution of orally administered casein nanoparticles. Food Chem Toxicol. 2017;106:477-486 pubmed publisher
..According to these results, the No Observed Adverse Effect Level (NOAEL) could be established in 150 mg/kg bw/day and the Lowest Observed Effect Level (LOEL) could be established in 500 mg/kg bw/day. ..
Iglesias T, Irache J, Butinar M, Turk B, Lopez de Cerain A, Azqueta A. Genotoxic evaluation of poly(anhydride) nanoparticles in the gastrointestinal tract of mice. Int J Pharm. 2017;530:187-194 pubmed publisher
..However, this effect was not observed at lower doses (i.e. 500 and 1000?mg/kg which are closer to the potential therapeutic doses) or in other organs. In conclusion, GN-MA-NP are promising nanocarriers as oral drug delivery systems. ..