Antonio Llombart-Bosch

Summary

Affiliation: University of Valencia
Country: Spain

Publications

  1. pmc Pulmonary artery sarcoma with angiosarcoma phenotype mimicking pleomorphic malignant fibrous histiocytoma: a case report
    Olga L Bohn
    Department of Pathology, Christus Mugerza UPAEP University Hospital, Puebla, 72000, Mexico
    Diagn Pathol 7:154. 2012
  2. pmc Three new chondrosarcoma cell lines: one grade III conventional central chondrosarcoma and two dedifferentiated chondrosarcomas of bone
    Jolieke G van Oosterwijk
    Department of Pathology, Leiden University Medical Center, Albinusdreef 2, 2333, ZA, Leiden, The Netherlands
    BMC Cancer 12:375. 2012
  3. pmc An integrated analysis of miRNA and gene copy numbers in xenografts of Ewing's sarcoma
    Neda Mosakhani
    Department of Pathology, Haartman Institute and HUSLAB, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland
    J Exp Clin Cancer Res 31:24. 2012
  4. pmc mRNA expression profiles of primary high-grade central osteosarcoma are preserved in cell lines and xenografts
    Marieke L Kuijjer
    Department of Pathology, Leiden University Medical Center, The Netherlands
    BMC Med Genomics 4:66. 2011
  5. ncbi request reprint Molecular analysis of the 9p21 locus and p53 genes in Ewing family tumors
    J A Lopez-Guerrero
    Department of Pathology, School of Medicine, University of Valencia, Valencia, Spain
    Lab Invest 81:803-14. 2001
  6. ncbi request reprint Immunohistochemical detection of EWS and FLI-1 proteinss in Ewing sarcoma and primitive neuroectodermal tumors: comparative analysis with CD99 (MIC-2) expression
    A Llombart-Bosch
    Department of Pathology, Medical School, University of Valencia, Spain
    Appl Immunohistochem Mol Morphol 9:255-60. 2001
  7. doi request reprint Histological heterogeneity of Ewing's sarcoma/PNET: an immunohistochemical analysis of 415 genetically confirmed cases with clinical support
    Antonio Llombart-Bosch
    Department of Pathology, University of Valencia, Ave Blasco Ibañez, 17, 46010, Valencia, Spain
    Virchows Arch 455:397-411. 2009
  8. doi request reprint Clinicopathological significance of cell cycle regulation markers in a large series of genetically confirmed Ewing's sarcoma family of tumors
    Jose Antonio Lopez-Guerrero
    Laboratory of Molecular Biology, Fundacion Instituto Valenciano de Oncologia, Valencia, Spain
    Int J Cancer 128:1139-50. 2011
  9. doi request reprint The epithelial mesenchymal transition process in wilms tumor: a study based on a xenograft model
    Francisco Giner
    Department of Pathology, Medical School, University of Valencia, Valencia, Spain
    Appl Immunohistochem Mol Morphol 19:369-75. 2011
  10. doi request reprint Molecular diagnosis of Ewing sarcoma family of tumors: a comparative analysis of 560 cases with FISH and RT-PCR
    Isidro Machado
    Department of Pathology, University of Valencia, Valencia, Spain
    Diagn Mol Pathol 18:189-99. 2009

Collaborators

Detail Information

Publications94

  1. pmc Pulmonary artery sarcoma with angiosarcoma phenotype mimicking pleomorphic malignant fibrous histiocytoma: a case report
    Olga L Bohn
    Department of Pathology, Christus Mugerza UPAEP University Hospital, Puebla, 72000, Mexico
    Diagn Pathol 7:154. 2012
    ..Intravascular angiosarcomas are aggressive neoplasms, often associated with poor outcome...
  2. pmc Three new chondrosarcoma cell lines: one grade III conventional central chondrosarcoma and two dedifferentiated chondrosarcomas of bone
    Jolieke G van Oosterwijk
    Department of Pathology, Leiden University Medical Center, Albinusdreef 2, 2333, ZA, Leiden, The Netherlands
    BMC Cancer 12:375. 2012
    ..In pre-clinical research aiming at the identification of novel treatment targets, the need for representative cell lines and model systems is high, but availability is scarce...
  3. pmc An integrated analysis of miRNA and gene copy numbers in xenografts of Ewing's sarcoma
    Neda Mosakhani
    Department of Pathology, Haartman Institute and HUSLAB, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland
    J Exp Clin Cancer Res 31:24. 2012
    ..Xenografts have been shown to provide a suitable source of tumor tissue for molecular analysis in the absence of primary tumor material. We utilized ES xenograft series for integrated microarray analyses to identify novel biomarkers...
  4. pmc mRNA expression profiles of primary high-grade central osteosarcoma are preserved in cell lines and xenografts
    Marieke L Kuijjer
    Department of Pathology, Leiden University Medical Center, The Netherlands
    BMC Med Genomics 4:66. 2011
    ..We aimed to investigate whether gene expression profiles of osteosarcoma cell lines and xenografts are still comparable to those of the primary tumor...
  5. ncbi request reprint Molecular analysis of the 9p21 locus and p53 genes in Ewing family tumors
    J A Lopez-Guerrero
    Department of Pathology, School of Medicine, University of Valencia, Valencia, Spain
    Lab Invest 81:803-14. 2001
    ..This fact points to an important role of the G(1)/S cell cycle checkpoint dysregulation in the pathogenesis of EFT...
  6. ncbi request reprint Immunohistochemical detection of EWS and FLI-1 proteinss in Ewing sarcoma and primitive neuroectodermal tumors: comparative analysis with CD99 (MIC-2) expression
    A Llombart-Bosch
    Department of Pathology, Medical School, University of Valencia, Spain
    Appl Immunohistochem Mol Morphol 9:255-60. 2001
    ..Whereas EWS expression does not appear specific for ES/PNET, analysis of FLI-1 expression together with CD-99 is a powerful marker for ES/PNET and important factors in the differential diagnosis of SRCT...
  7. doi request reprint Histological heterogeneity of Ewing's sarcoma/PNET: an immunohistochemical analysis of 415 genetically confirmed cases with clinical support
    Antonio Llombart-Bosch
    Department of Pathology, University of Valencia, Ave Blasco Ibañez, 17, 46010, Valencia, Spain
    Virchows Arch 455:397-411. 2009
    ..In conclusion, the diagnosis of atypical ES is a challenge for the pathologist and needs support from molecular techniques to perform an optimal differential diagnosis with other small round cell tumors...
  8. doi request reprint Clinicopathological significance of cell cycle regulation markers in a large series of genetically confirmed Ewing's sarcoma family of tumors
    Jose Antonio Lopez-Guerrero
    Laboratory of Molecular Biology, Fundacion Instituto Valenciano de Oncologia, Valencia, Spain
    Int J Cancer 128:1139-50. 2011
    ..In conclusion, this study demonstrates that Ki67 expression constitutes a valuable indicator of poor prognosis in localized ESFT...
  9. doi request reprint The epithelial mesenchymal transition process in wilms tumor: a study based on a xenograft model
    Francisco Giner
    Department of Pathology, Medical School, University of Valencia, Valencia, Spain
    Appl Immunohistochem Mol Morphol 19:369-75. 2011
    ....
  10. doi request reprint Molecular diagnosis of Ewing sarcoma family of tumors: a comparative analysis of 560 cases with FISH and RT-PCR
    Isidro Machado
    Department of Pathology, University of Valencia, Valencia, Spain
    Diagn Mol Pathol 18:189-99. 2009
    ..The second objective is to confirm the value of molecular methods and immunohistochemical (IHC) assays, to perform a differential diagnosis between ESFTs and SRCTs with similar or overlapping morphology...
  11. ncbi request reprint Evaluation of genetic stability of the SYT gene rearrangement by break-apart FISH in primary and xenotransplanted synovial sarcomas
    Manish Mani Subramaniam
    Department of Pathology, Medical School, University of Valencia, Avda Blasco Ibanez, 17, 46010 Valencia, Spain
    Cancer Genet Cytogenet 172:23-8. 2007
    ..The TMA-based FISH assay demonstrated genetic stability related to SYT gene rearrangement in primary and xenografted SS...
  12. ncbi request reprint Cytokeratin expression patterns in low-grade papillary urothelial neoplasms of the urinary bladder
    David Ramos
    Department of Pathology, University of Valencia Medical School, Valencia, Spain
    Cancer 97:1876-83. 2003
    ..The differential expression patterns of cytokeratin 20 (CK20) and 34betaE12 antigen in low-grade papillary urothelial tumors of the bladder are discussed...
  13. ncbi request reprint MYCN gain and MYCN amplification in a stage 4S neuroblastoma
    Rosa Noguera
    Deparment of Pathology, Medical School, University of Valencia, Avda Blasco Ibanez, 17, 46010 Valencia, Spain
    Cancer Genet Cytogenet 140:157-61. 2003
    ..We suggest that near-di-/tetraploid 4S tumors with MYCN gain and/or deletion 1p could be progressing 4S tumors...
  14. ncbi request reprint p16INK4A (CDKN2A) gene deletion is a frequent genetic event in synovial sarcomas
    Manish M Subramaniam
    Department of Pathology, Medical School, University of Valencia, Spain
    Am J Clin Pathol 126:866-74. 2006
    ..No significant association was observed between p16INK4A deletion and Ki-67 proliferation index, tumor grade, or histologic subtype. Our results demonstrate that p16INK4A (CDKN2A) gene deletion is a frequent genetic event in SS...
  15. ncbi request reprint Histological tumor grade correlates with HER2/c-erB-2 status in invasive breast cancer: a comparative analysis between immunohistochemical (CB11 clone and Herceptest), FISH and differential PCR procedures
    Jose Antonio Lopez-Guerrero
    Department of Pathology, School of Medicine, University of Valencia, Spain
    Arkh Patol 65:50-5. 2003
    ..However, due that sensitivity of IHC test is lower than FISH, we also suggest to carry out FISH on those cass in which IHC results are not definitive for its clinical evaluation...
  16. ncbi request reprint HER2 amplification in recurrent breast cancer following breast-conserving therapy correlates with distant metastasis and poor survival
    Jose A López-Guerrero
    Unit of Molecular Biology, Fundacion Instituto Valenciano de Oncologia, Valencia, Spain
    Int J Cancer 118:1743-9. 2006
    ..00008) and for survival (HR = 4.22; p = 0.004). In conclusion, HER2 amplification constitutes an independent poor prognostic factor for the MFI and OS in patients with recurrent breast cancer. The clinical implications are discussed...
  17. ncbi request reprint Dermatofibrosarcoma protuberans: a clinicopathological, immunohistochemical, genetic (COL1A1-PDGFB), and therapeutic study of low-grade versus high-grade (fibrosarcomatous) tumors
    Beatriz Llombart
    Department of Dermatology, Instituto Valenciano de Oncologia, Valencia, Spain
    J Am Acad Dermatol 65:564-75. 2011
    ..Dermatofibrosarcoma protuberans (DFSP) is an uncommon cutaneous tumor, usually low grade, except for the fibrosarcomatous variant (DFSP-FS)...
  18. ncbi request reprint Establishment and characterization of a continuous human chondrosarcoma cell line, ch-2879: comparative histologic and genetic studies with its tumor of origin
    Rosario Gil-Benso
    Department of Pathology, Medical School, University of Valencia, Valencia, Spain
    Lab Invest 83:877-87. 2003
    ....
  19. ncbi request reprint Epithelial cell adhesion molecules and epithelial mesenchymal transition (EMT) markers in Ewing's sarcoma family of tumors (ESFTs). Do they offer any prognostic significance?
    Isidro Machado
    Pathology Department, Instituto Valenciano de Oncologia, Valencia, Spain
    Virchows Arch 461:333-7. 2012
    ....
  20. ncbi request reprint Tissue microarray profiling of primary and xenotransplanted synovial sarcomas demonstrates the immunophenotypic similarities existing between SYT-SSX fusion gene confirmed, biphasic, and monophasic fibrous variants
    Manish Mani Subramaniam
    Department of Pathology, Faculty of Medicine, University of Valencia, Valencia, Spain
    Virchows Arch 449:435-47. 2006
    ..Nonetheless, reverse-transcriptase-polymerase chain reaction detected SYT-SSX transcripts in all primary SSs and their xenografts, thereby demonstrating their genetic stability...
  21. doi request reprint Gain of MYCN region in a Wilms tumor-derived xenotransplanted cell line
    Rosa Noguera
    Department of Pathology, University of Valencia, Blasco Ibanez 17, Valencia, Spain
    Diagn Mol Pathol 19:33-9. 2010
    ..MYCN is already used as a stratifying marker in neuroblastomas, and it may be also useful in implementing MYCN testing in prospective studies of Wilms tumors...
  22. ncbi request reprint Deregulation of the G1 to S-phase cell cycle checkpoint is involved in the pathogenesis of human osteosarcoma
    Jose Antonio Lopez-Guerrero
    Department of Pathology, School of Medicine, University of Valencia, Spain
    Diagn Mol Pathol 13:81-91. 2004
    ..007). Hence, in the pathogenesis of human OS, deregulation of the G1/S checkpoint genes, especially RB, TP53, and INK4/ARF locus, plays an important role and defines a subgroup of patients with a poor outcome...
  23. ncbi request reprint Cytogenetic and molecular findings related to rhabdomyosarcoma. An analysis of seven cases
    Rosario Gil-Benso
    Department of Pathology, Medical School, University of Valencia, Avda Blasco Ibanez 17, Valencia 46010, Spain
    Cancer Genet Cytogenet 144:125-33. 2003
    ..Analysis of the regulatory genes responsible for G1- to S-phase transition showed a homozygous deletion of the 9p21 locus genes in a spindle-cell ERMS...
  24. doi request reprint Analysis of biological prognostic factors using tissue microarrays in neuroblastic tumors
    Marta Piqueras
    Department of Pathology, Medical School, University of Valencia, Valencia, Spain
    Pediatr Blood Cancer 52:209-14. 2009
    ..We compare the results obtained by different molecular techniques at different substrates to evaluate the feasibility of these assays...
  25. doi request reprint Inflammatory fibroid polyp of the small bowel with a mutation in exon 12 of PDGFR alpha
    Silvia Calabuig-Fariñas
    Department of Pathology, School of Medicine, University of Valencia, Valencia, Spain
    Virchows Arch 454:327-31. 2009
    ..We concluded that more studies are necessary in order to clarify if this finding is a biologically distinct behavior or, on the contrary, represents a specific feature of the IFP...
  26. doi request reprint Evaluation of prognostic factors and their capacity to predict biological behavior in gastrointestinal stromal tumors
    Silvia Calabuig-Fariñas
    University of Valencia, Valencia, Spain
    Int J Surg Pathol 19:448-61. 2011
    ..In conclusion, complete clinicopathological, immunohistochemical, and genetic descriptions are necessary to characterize this disease and optimize its clinical management...
  27. ncbi request reprint Expression of CCN3 protein in human Wilms' tumors: immunohistochemical detection of CCN3 variants using domain-specific antibodies
    Manish Mani Subramaniam
    Department of Pathology, Medical School, University of Valencia, Valencia, Spain
    Virchows Arch 452:33-9. 2008
    ..Thus, the domain-specific antibodies represent valuable tools for detecting CCN3 protein variants in normal and neoplastic kidneys...
  28. doi request reprint Galectin-1 (GAL-1) expression is a useful tool to differentiate between small cell osteosarcoma and Ewing sarcoma
    Isidro Machado
    Department of Pathology, Instituto Valenciano de Oncologia, Valencia, Spain
    Virchows Arch 462:665-71. 2013
    ..GAL-1 immunoexpression is not indicative of prognosis in ESFT...
  29. ncbi request reprint Characterization of a new human cell line (CH-3573) derived from a grade II chondrosarcoma with matrix production
    Silvia Calabuig-Fariñas
    Department of Pathology, University of Valencia, Avda Blasco Ibanez, 17, 46010, Valencia, Spain
    Pathol Oncol Res 18:793-802. 2012
    ..The cell line (CH-3573) was characterized by pathological, immunohistochemical and molecular genetic methods...
  30. doi request reprint Superficial small round-cell tumors with special reference to the Ewing's sarcoma family of tumors and the spectrum of differential diagnosis
    Isidro Machado
    Department of Pathology, Instituto Valenciano de Oncologia, Valencia, Spain
    Semin Diagn Pathol 30:85-94. 2013
    ..Our aim is to review the most common types of small round-cell tumors included in the differential diagnosis of superficial ESFT, analyzing the histopathology, phenotype, and molecular alterations of each entity...
  31. doi request reprint The many faces of atypical Ewing's sarcoma. A true entity mimicking sarcomas, carcinomas and lymphomas
    Isidro Machado
    Pathology Department, Medical School, Valencia University, Avda Blasco Ibanez, 15, Valencia, 46010, Spain
    Virchows Arch 458:281-90. 2011
    ..Thus, we confirm that the integration of clinical, histopathological, IHC and genetic data becomes decisive in the diagnosis of bone and soft tissue sarcomas...
  32. ncbi request reprint Association of loss of 1p and alterations of chromosome 14 in meningioma progression
    Concha Lopez-Gines
    Department of Pathology, Medical School, University of Valencia, Avda Blasco Ibanez 17, 46010 Valencia, Spain
    Cancer Genet Cytogenet 148:123-8. 2004
    ..These results support the possible association between changes in 1p and chromosome 14 with the evolution of aggressive meningiomas through tumor progression...
  33. doi request reprint Epithelial marker expression does not rule out a diagnosis of Ewing's sarcoma family of tumours
    Isidro Machado
    Pathology Department, University of Valencia, Blasco Ibañez, 16, 46015, Valencia, Spain
    Virchows Arch 459:409-14. 2011
    ....
  34. doi request reprint Alterations of ubiquitylation and sumoylation in conventional renal cell carcinomas after the Chernobyl accident: a comparison with Spanish cases
    Luisa Morell-Quadreny
    Department of Pathology, Medical School of Valencia University, Avda Blasco Ibanez 17, 46010, Valencia, Spain
    Virchows Arch 459:307-13. 2011
    ..These findings do not allow us to consider the immunohistochemical expression of ubiquitylation and sumoylation as valuable markers for discriminating the effects of long-term, low-dose IR exposure in cRCC carcinogenesis...
  35. doi request reprint Superficial Ewing's sarcoma family of tumors: a clinicopathological study with differential diagnoses
    Isidro Machado
    Pathology Department, Medical School, Valencia University, Valencia, Spain
    J Cutan Pathol 38:636-43. 2011
    ..The aim of the present study is to describe the clinicopathological characteristics of six genetically confirmed ESFT presenting a superficial location...
  36. ncbi request reprint Immunohistochemical expression of Ki-67 antigen, cox-2 and Bax/Bcl-2 in prostate cancer; prognostic value in biopsies and radical prostatectomy specimens
    J Rubio
    Urology Service, Instituto Valenciano de Oncología IVO, C Prof Beltrán Báguena 8, 46009, Valencia, Spain
    Eur Urol 48:745-51. 2005
    ..To elucidate the prognostic value of the immunohistochemical (IHC) expression of Bcl-2, Bax, Cox-2 and Ki-67 antigen in biopsy cores (C) and surgical specimens (SP) of prostate cancer (PC) and to determine the C to SP reproducibility...
  37. ncbi request reprint Prognostic value of morphometry in low grade papillary urothelial bladder neoplasms
    David Ramos
    Department of Pathology, Medical School, University of Valencia, Valencia, Spain
    Anal Quant Cytol Histol 26:285-94. 2004
    ..To analyze the prognostic value of morphometry in low grade papillary urothelial bladder neoplasms (LGPUBNs)...
  38. ncbi request reprint Morphometric analysis of DNA ploidy and nuclear cell cycle regulators in Ewing's sarcoma/primitive neuroectodermal tumor
    Isidro Machado
    Department of Pathology, University of Valencia, Valencia, Spain
    Anal Quant Cytol Histol 33:101-10. 2011
    ....
  39. doi request reprint A tissue microarray study of osteosarcoma: histopathologic and immunohistochemical validation of xenotransplanted tumors as preclinical models
    Empar Mayordomo
    Department of Pathology, University of Valencia, Valencia, Spain
    Appl Immunohistochem Mol Morphol 18:453-61. 2010
    ..Osteosarcomas (OS) are aggressive neoplasms with a wide range of morphologic patterns...
  40. ncbi request reprint P16INK4A and p15INK4B gene alteration associated with oxidative stress in renal cell carcinomas after the chernobyl accident (pilot study)
    Alina Romanenko
    Department of Pathology, Medical School, University of Valencia, Spain
    Diagn Mol Pathol 11:163-9. 2002
    ..Our data suggest that inactivation of p16 gene, but not p15, induced by increased oxidative stress generated by persistent chronic exposure to IR, could be one of the major pathways responsible for RCCs malignant progression...
  41. ncbi request reprint EWS/FLI-1 rearrangement in small round cell sarcomas of bone and soft tissue detected by reverse transcriptase polymerase chain reaction amplification
    A Pellin
    Department of Pathology, Medical School, University of Valencia, Spain
    Eur J Cancer 30:827-31. 1994
    ..These results reinforce the value of molecular biology techniques for the correct assessment of histology difficult evaluable neoplasms, such as the group of small round cell tumours within the Es family...
  42. ncbi request reprint GIST: particular aspects related to cell cultures, xenografts, and cytogenetics
    Jose Antonio Lopez-Guerrero
    Unit of Molecular Biology, Fundacion Instituto Valenciano de Oncologia, Valencia, Spain
    Semin Diagn Pathol 23:103-10. 2006
    ..A deeper knowledge of these genetic aspects of GIST will provide a better understanding of this neoplasm that could translate into clinical practice...
  43. ncbi request reprint Mutational analysis of the c-KIT AND PDGFRalpha in a series of molecularly well-characterized synovial sarcomas
    Jose Antonio Lopez-Guerrero
    Unit of Molecular Biology of the Fundación Valenciano de Oncología, Valencia, Spain
    Diagn Mol Pathol 14:134-9. 2005
    ..We suggest that a more exhaustive mutational analysis of the c-KIT and PDGFRalpha genes should be performed to ascertain which cases would really benefit from a tyrosine kinase inhibitor therapy in SS...
  44. doi request reprint Pleomorphic hyalinizing angiectatic tumor: a report of 3 new cases, 1 with sarcomatous myxofibrosarcoma component and another with unreported soft tissue palpebral location
    Carmen Illueca
    Department of Pathology, Instituto Valenciano de Oncologia, Valencia University, Valencia, Spain
    Appl Immunohistochem Mol Morphol 20:96-101. 2012
    ..Indeed, the possibility that PHAT may represent a histopathologic pattern and not a true neoplastic entity with specific genetic alterations cannot be excluded at present, and further studies are required...
  45. ncbi request reprint Prognostic value of the International Neuroblastoma Pathology Classification in Neuroblastoma (Schwannian stroma-poor) and comparison with other prognostic factors: a study of 182 cases from the Spanish Neuroblastoma Registry
    Octavio Burgues
    Departamento de Patologia, Facultad de Medicina de Valencia, Avda Blasco Ibanez, 17, E 46010, Pediatric Oncology Unit, Hospital Universitario La Fe, Valencia, Spain
    Virchows Arch 449:410-20. 2006
    ..001). INPC classification results are major prognostic indicators in NB and should be considered in the therapeutic stratification of NB patients...
  46. ncbi request reprint Poorly differentiated adenocarcinomas of prostate versus high-grade urothelial carcinoma of the bladder: a diagnostic dilemma with immunohistochemical evaluation of 2 cases
    Miguel Martinez-Rodriguez
    University Clinic Hospital of Valencia, Medical School, Department of Pathology, Valencia, Spain
    Int J Surg Pathol 15:213-8. 2007
    ..The differentiating histological and immunohistochemical findings are discussed...
  47. doi request reprint Immunohistochemical study of correlation between histologic subtype and expression of epithelial-mesenchymal transition-related proteins in synovial sarcomas
    Manish Mani Subramaniam
    Department of Pathology, Medical School, University of Valencia, Spain
    Arch Pathol Lab Med 135:1001-9. 2011
    ..However, factors determining epithelial or spindle cell differentiation are still unexplored. Aberrant epithelial-mesenchymal transition has been implicated in the pathogenesis of diverse human malignancies...
  48. ncbi request reprint Anaplastic carcinoma of the thyroid with rhabdomyosarcomatous differentiation: a report of two cases
    Carmen Carda
    Department Pathology, Faculty of Medicine, University of Valencia, Av Blasco Ibanez 17, 46010 Valencia, Spain
    Virchows Arch 446:46-51. 2005
    ..These findings may contribute to the broadening of the differentiation spectrum of this unusual neoplasm...
  49. doi request reprint Superficial EWSR1-negative undifferentiated small round cell sarcoma with CIC/DUX4 gene fusion: a new variant of Ewing-like tumors with locoregional lymph node metastasis
    Isidro Machado
    Pathology Department, Instituto Valenciano de Oncologia, Valencia, Spain
    Virchows Arch 463:837-42. 2013
    ....
  50. ncbi request reprint Recombinations of chromosomal bands 10q24, 12q14-q15, and 14q24 in two cases of pulmonary chondroid hamartoma studied by fluorescence in situ hybridization
    Maria Aurelia Gregori-Romero
    Department of Pathology, Facultad de Medicina y Odontologia, Universidad de Valencia, Spain
    Cancer Genet Cytogenet 142:153-7. 2003
    ..Our data have been confirmed with fluorescence in situ hybridization analysis. These cases represent variant forms of the standard translocations...
  51. pmc A polymorphism at the 3'-UTR region of the aromatase gene defines a subgroup of postmenopausal breast cancer patients with poor response to neoadjuvant letrozole
    Zaida Garcia-Casado
    Laboratory of Molecular Biology, Fundacion Instituto Valenciano de Oncologia, Valencia, Spain
    BMC Cancer 10:36. 2010
    ..We evaluate a series of polymorphisms of CYP19A1 and their effect on response to neoadjuvant letrozole in early BC...
  52. ncbi request reprint Dermatofibrosarcoma protuberans: clinical, pathological, and genetic (COL1A1-PDGFB ) study with therapeutic implications
    Beatriz Llombart
    Department of Dermatology, University of Valencia, Valencia, Spain
    Histopathology 54:860-72. 2009
    ....
  53. ncbi request reprint [Analysis of the COL1A1-PDGFB fusion gene in a case of dermatofibrosarcoma protuberans with a fibrosarcoma component]
    Beatriz Llombart
    Servicio de Dermatologia, Instituto Valenciano de Oncologia, Valencia, Espana
    Actas Dermosifiliogr 97:337-41. 2006
    ..It also justifies the use of new avenues of treatment with tyrosine kinase inhibitors...
  54. ncbi request reprint Study of proliferation and apoptosis in neuroblastoma. Their relation with other prognostic factors
    Ma del Carmen Mejía
    Departamento de Neurociencias, Instituto de Fisiologia Celular, Universidad Nacional Autonoma de Mexico UNAM, Mexico City, Mexico
    Arch Med Res 33:466-72. 2002
    ..Our objective was to study the proliferation and apoptotic process in 111 cases of neuroblastoma (NB) and to seek their relationship with other prognostic factors and survival...
  55. ncbi request reprint Apoptosis in peripheral neuroblastic tumors. Immunohistochemical expression of bcl-2 and p53 is related to DNA fragmentation
    C Mejia
    Instituto de Neurobiologia, Universidad Nacional Autonoma de Mexico, Queretaro, Mexico
    Histol Histopathol 22:1365-70. 2007
    ..Multivariate analysis showed bcl-2 protein expression to be the most independent risk factor. The study of apoptosis could be important for the design of therapies to treat neuroblastoma...
  56. doi request reprint Low levels of WWOX protein immunoexpression correlate with tumour grade and a less favourable outcome in patients with urinary bladder tumours
    D Ramos
    Department of Pathology, School of Medicine, University of Valencia, Valencia, Spain
    Histopathology 52:831-9. 2008
    ..To correlate the immunohistochemical detection of WWOX with histological measures and disease progression within the whole spectrum of urothelial bladder neoplasms...
  57. ncbi request reprint Ultrastructural and immunohistochemical characterization of the so-called giant multinucleate cells in cutaneous collagenomas
    D Ramos
    Department of Pathology, Medical School and University Clinic Hopital of Valencia, Avda Blasco Ibanez, Spain
    Histopathology 41:134-43. 2002
    ..This study was undertaken to compare the histopathological, immunohistochemical and ultrastructural features of the so-called giant multi nucleate cells in cutaneous collagenomas: giant-cell collagenoma and solitary sclerotic fibroma...
  58. ncbi request reprint Loss of 1p in recurrent meningiomas. a comparative study in successive recurrences by cytogenetics and fluorescence in situ hybridization
    C Lopez-Gines
    Department of Pathology, Medical School, University of Valencia, Av Blasco Ibanez, 17, 46010, Valencia, Spain
    Cancer Genet Cytogenet 125:119-24. 2001
    ..These results were more evident in the analysis of direct and touch preparations than in those of cultured cells...
  59. ncbi request reprint Clinicopathological and immunohistochemical analysis of 20 cases of Merkel cell carcinoma in search of prognostic markers
    B Llombart
    Department of Pathology, Instituto Valenciano de Oncologia, Valencia, Spain
    Histopathology 46:622-34. 2005
    ..To evaluate the clinicopathological and immunohistochemical characteristics of Merkel cell carcinoma (MCC) in an attempt to find new, potentially significant, prognostic markers...
  60. pmc CXCR3 chemokine receptor immunoreactivity in primary cutaneous malignant melanoma: correlation with clinicopathological prognostic factors
    C Monteagudo
    Department of Pathology, University of Valencia, Spain
    J Clin Pathol 60:596-9. 2007
    ..A role for CXCR3, the receptor for chemokines Mig, IP-10 and interferon-inducible T cell alpha-chemoattractant, in tumour cell migration during melanoma progression has been proposed...
  61. ncbi request reprint [Genomic profile in high risk neuroblastoma by comparative genomic hybridization]
    R Noguera Salvá
    Departamento de Patologia, Facultad de Medicina y Odontologia, Universidad de Valencia, Espana
    An Pediatr (Barc) 64:449-56. 2006
    ..Genomic profiling by CGH in NB-HR confirms the interaction among genetic alterations, the prognostic significance of which should be evaluated to establish new treatment criteria...
  62. ncbi request reprint [Usefulness of bcl-2 expression as a new basal cell marker in prostatic pathology]
    D Ramos Soler
    Departamento de Patologia, Facultad de Medicina, Universitat de Valencia
    Actas Urol Esp 30:345-52. 2006
    ..In our study, we analyzed comparatively the expression of 34betaE12, p63, bcl-2 and alpha-methylacyl-CoA racemase in order to evaluate the usefulness of bcl-2 as a new marker of the basal cells in prostatic pathology...
  63. ncbi request reprint TuBaFrost 4: access rules and incentives for a European tumour bank
    J A Lopez-Guerrero
    Unit of Molecular Biology, Fundacion Instituto Valenciano de Oncologia, C Profesor Beltran Baguena, 8 11, Valencia, Spain
    Eur J Cancer 42:2924-9. 2006
    ..With this general purpose in mind, the rules and responsibilities for collectors, requestors and central office were generated...
  64. ncbi request reprint Study of bcl-2 protein expression and the apoptosis phenomenon in neuroblastoma
    M C Mejia
    Department of Pathology, Medical School, University of Valencia, Spain
    Anticancer Res 18:801-6. 1998
    ..Recent reports indicate that bcl-2 protein expression is associated with a poor outcome in patients with neuroblastoma...
  65. ncbi request reprint Nasal glioma or nasal glial heterotopia? Morphological, immunohistochemical and ultrastructural study of two cases
    M Cerda-Nicolas
    Department of Pathology, Clinical Hospital, University of Valencia, Spain
    Clin Neuropathol 21:66-71. 2002
    ....
  66. ncbi request reprint Atypical pleomorphic extraosseous ewing tumor/peripheral primitive neuroectodermal tumor with unusual phenotypic/genotypic profile
    S Navarro
    Department of Pathology, Medical School, University of Valencia, Valencia, Spain
    Diagn Mol Pathol 11:9-15. 2002
    ....
  67. ncbi request reprint Psammomatous malignant melanoma arising in an intradermal naevus
    C Monteagudo
    Department of Pathology, Hospital Clinico Universitario, University of Valencia, Valencia, Spain
    Histopathology 39:493-7. 2001
    ..A wide variety of differentiation patterns may be found in malignant melanoma. Schwannian features are unusual, and mostly present in the desmoplastic variant. We report the first description of psammoma bodies in malignant melanoma...
  68. ncbi request reprint Translocation (10;11;22)(p14;q24;q12) characterized by fluorescence in situ hybridization in a case of Ewing's tumor
    R Noguera
    Department of Pathology, Medical School, University of Valencia, Spain
    Diagn Mol Pathol 10:2-8. 2001
    ....
  69. ncbi request reprint Electron microscopy and other ancillary techniques in the diagnosis of small round cell tumors
    Amando Peydro-Olaya
    Department of Pathology, Medical School and Hospital Clinico, University of Valencia, Valencia, Spain
    Semin Diagn Pathol 20:25-45. 2003
    ..Thus, short references on molecular genetics, complementing the structural findings, are given...
  70. ncbi request reprint Structural basis of tumoral angiogenesis
    Antonio Llombart-Bosch
    Department of Pathology, University of Valencia, Avda Blasco Ibanez, 17, 46010 Valencia, Spain
    Adv Exp Med Biol 532:69-89. 2003
  71. ncbi request reprint CD99 immunoreactivity in atypical fibroxanthoma: a common feature of diagnostic value
    Carlos Monteagudo
    Department of Pathology, University of Valencia, Spain
    Am J Clin Pathol 117:126-31. 2002
    ..To our knowledge, this is the first report of CD99 and PGP9.5 immunostaining in AFX. We believe, based on our results, that CD99 may be a helpful "positive" feature in the histopathologic diagnosis of AFX...
  72. ncbi request reprint New type of chimeric fusion product between the EWS and ATFI genes in clear cell sarcoma (malignant melanoma of soft parts)
    A Pellin
    Department of Pathology, Medical School, University of Valencia, Spain
    Genes Chromosomes Cancer 23:358-60. 1998
    ..This breakpoint has not been reported previously and indicates an important in vivo loss of EWS and ATFI gene domains, which could be associated with the unusually aggressive behavior of this tumor...
  73. ncbi request reprint Histology, immunohistochemistry, and electron microscopy of small round cell tumors of bone
    A Llombart Bosch
    Department of Pathology, Medical School, University of Valencia, Spain
    Semin Diagn Pathol 13:153-70. 1996
    ..Malignant non-Hodgkin's lymphoma is an unusual presentation when primary to the bone, previous to any other anatomic location. Several subtypes have been considered within a histology that encompasses that seen in lymph nodes...
  74. ncbi request reprint Immunophenotypic profile of biomarkers related to anti-apoptotic and neural development pathways in the Ewing's family of tumors (EFT) and their therapeutic implications
    S Navarro
    Department of Pathology, Medical School, University of Valencia, Spain
    Anticancer Res 27:2457-63. 2007
    ..The aim of the present study was to analyse the expression of these molecules in paraffin-embedded material from a series of EFT...
  75. ncbi request reprint Molecular alterations of the RB1, TP53, and MDM2 genes in primary and xenografted human osteosarcomas
    A Pellin
    Department of Pathology, Medical School, University of Valencia, Spain
    Diagn Mol Pathol 6:333-41. 1997
    ..TP53 mutations appear in adult patients, whereas RB1 alterations occur mostly in younger patients...
  76. ncbi request reprint Diffuse type of giant-cell tumor of tendon sheath: an ultrastructural study of two cases with cytogenetic support
    Jaime Ferrer
    Department of Pathology, Medical School, University of Valencia, Spain
    Ultrastruct Pathol 26:15-21. 2002
    ..Present findings provide further support regarding the neoplasic nature of this tumoral entity...
  77. ncbi request reprint Ductal carcinoma in situ of the breast: a comparative analysis of histology, nuclear area, ploidy, and neovascularization provides differentiation between low- and high-grade tumors
    Amparo Ruiz
    Department of Pathology, Medical School, University of Valencia, Spain
    Breast J 8:139-44. 2002
    ..These criteria should justify a higher rate of tumor progression to DCIS grade III...
  78. ncbi request reprint Cytogenetic findings in malignant mixed mesodermal tumors of the uterus
    R Gil Benso
    Department of Pathology, University Clinic Hospital, Medical School, University of Valencia, Spain
    Cancer Genet Cytogenet 99:121-5. 1997
    ..The chromosomes most often involved in structural rearrangements were chromosomes 1, 9, 11, 12, 17, and 19. Double minutes, homogeneously staining regions, and telomeric association were also seen...
  79. ncbi request reprint Immunohistochemical characterization of 130 cases of primary hepatic carcinomas
    A Ferrandez Izquierdo
    Department of Pathology, Medical School, University of Valencia, Spain
    Pathol Res Pract 182:783-91. 1987
    ..Therefore the present results confirm that in the geographical area from which these tumors proceed, PLC is closely correlated with HBsAg positivity and with cirrhosis...
  80. ncbi request reprint Atrophic dermatofibrosarcoma protuberans with the fusion gene COL1A1-PDGFB
    B Llombart
    J Eur Acad Dermatol Venereol 22:371-4. 2008
  81. ncbi request reprint TuBaFrost: European virtual tumor tissue banking
    P H J Riegman
    The TuBaFrost Consortium, Erasmus Medical Center, Dr Molewaterplein 50, 3015 GE Rotterdam, The Netherlands
    Adv Exp Med Biol 587:65-74. 2006
    ..Thereby, improving availability of large amounts of high quality samples of a highly specified or rare tumor types and contact opportunities for cooperation with other institutes...
  82. ncbi request reprint Characterization of a new rat cell line established from 2'AAF-induced combined hepatocellular cholangiocellular carcinoma
    R Gil-Benso
    Department of Pathology, Medical School, University of Valencia, Spain
    In Vitro Cell Dev Biol Anim 37:17-25. 2001
    ..The resulting cells expressed biological and morphological markers of hepatocytes and cholangiolar cells. Therefore this cell line may contribute to a better understanding of the histogenesis of liver cancer...
  83. ncbi request reprint Virtual microscopy in virtual tumor banking
    M Isabelle
    EORTC Data Center, Avenue E Mounier 83, B 1200 Brussels, Belgium
    Adv Exp Med Biol 587:75-86. 2006
    ..A system of complete pathology review supporting biorepositories is described, based on the implementation of this technique in the European Human Frozen Tumor Tissue Bank (TuBaFrost)...
  84. ncbi request reprint Small-cell carcinoma of the urinary bladder. A clinico-pathological study of ten cases
    P Soriano
    Departments of Pathology, University of Valencia, University of Valencia, Avda Blasco Ibanez 17, 46010 Valencia, Spain
    Virchows Arch 445:292-7. 2004
    ..In this paper, we confirm the aggressive course of the neoplastic disease. The expression of c-erbB2 in 50% of cases opens up hypothetical new possibilities for the use of immunotherapy in such cases...
  85. ncbi request reprint Disruption of basement membrane, extracellular matrix metalloproteinases and E-cadherin in renal-cell carcinoma
    L Morell-Quadreny
    Department of Pathology, Medical School of Valencia, Avda Blasco Ibanez, 17, 46010 Valencia, Spain
    Anticancer Res 23:5005-10. 2003
    ..A retrospective study was performed to determine the prognostic value of Basement Membrane (BM) integrity, Matrix Metalloproteinases (MMPs) and E-Cadherin expression in renal cell carcinoma (RCC)...
  86. ncbi request reprint Malignant granular cell tumor of soft tissues: a study of two new cases
    J Cruz-Mojarrieta
    Department of Pathology, Oncology Institute, C. Habana, Cuba
    Int J Surg Pathol 9:255-9. 2001
    ..In addition, high expression of p53 and MiB1 (Ki67) was detected. Herein, we discuss the morphologic and immunohistochemical criteria of malignancy of granular cell tumors. Int J Surg Pathol 9(3):255-259, 2001..
  87. ncbi request reprint Primitive neuroectodermal tumor of the uterus. A case report
    A I Karseladze
    Department of Pathology, Cancer Research Centre, Moscow, Russia
    J Reprod Med 46:845-8. 2001
    ..Four years later she was alive, without signs of recurrent tumor. CONCLUSION: In spite of the generally recognized aggressive behavior of PNET, it can have a long disease-free survival rate when appropriately treated...
  88. ncbi request reprint Cutaneous sclerosing Pacinian-like perineurioma
    O Burgues
    Department of Pathology, , University of Valencia, Valencia, Spain
    Histopathology 39:498-502. 2001
    ..CONCLUSIONS: This case may be considered a new variant of perineurioma with Pacinian-like features, for which we propose the designation 'sclerosing Pacinian-like perineurioma'...
  89. ncbi request reprint [Idiopathic granulomatous hypophysitis. Morphological and immunohistochemical study of a case]
    C Illueca
    Departamento de Patologia, Hospital Clinico Universitario, Facultad de Medicina, Universidad de Valencia
    Neurocirugia (Astur) 13:137-41. 2002
    ..We analyze the differential diagnosis with another granulomatous processes, infectious or not infectious, and with the histiocytosis. We examine the possible relation with the lymphocytic hypophysitis...
  90. ncbi request reprint Diffuse hypersecretory micropapillary invasive carcinoma: an unusual ductal carcinoma
    P Soriano
    Department of Pathology, University Clinic Hospital, Unit of Diagnosis of Mammary Pathology, Valencia, Spain
    Breast J 9:138-40. 2003
  91. ncbi request reprint Synovial sarcoma (SS): new perspectives supported by modern technology
    A Llombart-Bosch
    Department of Pathology, Medical School, University of Valencia, Spain
    Arkh Patol 64:39-47. 2002
    ..Moreover, clinical correlations have demonstrated that SYT-SSX1 leads to a poor clinical outcome while the fusion SYT-SSX2 provides survival advantages to the patients...
  92. ncbi request reprint Analysis of cribriform Gleason grade 3 in prostatic carcinoma. A histopathological and immunohistochemical study of 32 cases
    M Martinez-Rodriguez
    Histopathology 51:717-9. 2007
  93. ncbi request reprint Neuroectodermal immunophenotype in uterine malignant mullerian tumors (MMT): comparative immunohistochemical analysis with embryonal uterine development
    A Karseladze
    Department of Pathology, Cancer Research Centre, Moscow, Russia
    Eur J Gynaecol Oncol 25:71-8. 2004
    ..Taking into consideration the capacity of uterine tissue to reproduce embryonal phenotype during neoplastic transformation, we studied this abnormal immunoprofile and its hypothetic value for the diagnosis and prognosis of MMT...