Javier Leon

Summary

Affiliation: University of Cantabria
Country: Spain

Publications

  1. ncbi request reprint Novel triiodophenol derivatives induce caspase-independent mitochondrial cell death in leukemia cells inhibited by Myc
    Matilde Parreño
    Departamento de Biologia Molecular, Facultad de Medicina, Universidad de Cantabria, Avenida Cardenal Herrera Oria, s n 39011 Santander, Cantabria, Spain
    Mol Cancer Ther 5:1166-75. 2006
  2. ncbi request reprint Inhibition of cell differentiation: a critical mechanism for MYC-mediated carcinogenesis?
    Javier Leon
    Departamento de Biologia Molecular, Facultad de Medicina, Instituto de Biomedicina y Biotecnología de Cantabria, Universidad de Cantabria CSIC IDICAN, Avda Cardenal Herrera Oria s n Santander, Spain
    Cell Cycle 8:1148-57. 2009
  3. pmc Myc inhibits p27-induced erythroid differentiation of leukemia cells by repressing erythroid master genes without reversing p27-mediated cell cycle arrest
    Juan C Acosta
    Cancer Molecular Biology Group, Department of Molecular Biology, Instituto de Biomedicina y Biotecnología de Cantabria, Universidad de Cantabria CSIC IDICAN, Santander, Spain
    Mol Cell Biol 28:7286-95. 2008
  4. ncbi request reprint Myc antagonizes Ras-mediated growth arrest in leukemia cells through the inhibition of the Ras-ERK-p21Cip1 pathway
    Jose P Vaque
    Grupo de Biología Molecular del Cáncer, Departamento de Biologia Molecular, Unidad de Biomedicina del Consejo Superior de Investigaciones Cientiíficas, Facultad de Medicina, Universidad de Cantabria, 39011 Santander, Spain
    J Biol Chem 280:1112-22. 2005
  5. doi request reprint MYC in chronic myeloid leukemia: induction of aberrant DNA synthesis and association with poor response to imatinib
    Marta Albajar
    Departamento de Biologia Molecular, Facultad de Medicina, Instituto de Biomedicina y Biotecnología de Cantabria, Avda Cardenal Herrera Oria s n, 39011 Santander, Spain
    Mol Cancer Res 9:564-76. 2011
  6. ncbi request reprint Amifostine impairs p53-mediated apoptosis of human myeloid leukemia cells
    Juan C Acosta
    Grupo de Biología Molecular del Cáncer, Departamento de Biologia Molecular, Unidad de Biomedicina CSIC, Universidad de Cantabria, Santander, Spain
    Mol Cancer Ther 2:893-900. 2003
  7. doi request reprint c-Myc inhibits Ras-mediated differentiation of pheochromocytoma cells by blocking c-Jun up-regulation
    Jose P Vaque
    Grupo de Biología Molecular del Cáncer, Dpto de Biología Molecular and Instituto de Biomedicina y Biotecnología de Cantabria, Universidad de Cantabria CSIC IDICAN, Santander, Spain
    Mol Cancer Res 6:325-39. 2008
  8. pmc SKP2 oncogene is a direct MYC target gene and MYC down-regulates p27(KIP1) through SKP2 in human leukemia cells
    Gabriel Bretones
    Departamento de Biologia Molecular, Instituto de Biomedicina y Biotecnología de Cantabria, Universidad de Cantabria, Consejo Superior de Investigaciones Cientificas, SODERCAN Sociedad para el Desarrollo de Cantabria, 39011 Santander, Spain
    J Biol Chem 286:9815-25. 2011
  9. ncbi request reprint Targeting of CTCF to the nucleolus inhibits nucleolar transcription through a poly(ADP-ribosyl)ation-dependent mechanism
    Verónica Torrano
    Grupo de Biología Molecular del Cáncer, Departamento de Biologia Molecular, Universidad de Cantabria, 39011 Santander, Spain
    J Cell Sci 119:1746-59. 2006
  10. pmc p21 as a transcriptional co-repressor of S-phase and mitotic control genes
    Nuria Ferrandiz
    Departamento de Biologia Molecular, Instituto de Biomedicina y Biotecnología de Cantabria IBBTEC, Universidad de Cantabria CSIC SODERCAN, Santander, Spain
    PLoS ONE 7:e37759. 2012

Collaborators

  • Yuzuru Shiio
  • Elena Klenova
  • Francisco Portillo
  • Lars Gunnar Larsson
  • Rainer Renkawitz
  • Jose L Fernandez-Luna
  • Piero Crespo
  • Atanasio Pandiella
  • Neus Agell
  • Anna Bigas
  • Wen Chun Hung
  • Francisco Martin
  • Isabel Sanchez-Perez
  • Josep F Nomdedeu
  • Marikki Laiho
  • Alberto Gandarillas
  • Rosario Perona
  • Jose C Reyes
  • M Dolores Delgado
  • Gabriel Bretones
  • Nuria Ferrandiz
  • Marta Albajar
  • Juan C Acosta
  • Isolda Casanova
  • M Teresa Gómez-Casares
  • Matilde Parreño
  • Juan M Caraballo
  • Jose P Vaque
  • Maria J Munoz-Alonso
  • Rosa Blanco
  • Ramon Mangues
  • Verónica Torrano
  • Lucía García-Gutierrez
  • María Virtudes Céspedes
  • Miguel Angel Pavon
  • Pablo García-Sanz
  • Carlos Richard
  • Itsaso Mauleon
  • Eva García-Alegría
  • M Carmen Lafita
  • Andrea Quintanilla
  • Javier Llorca
  • Silvia Guerrero
  • Manuel Trias
  • Nuria Ajenjo
  • Lourdes Farre
  • Matilde Canelles
  • Pilar Frade
  • Martin Eilers
  • John Sedivy
  • Eugenio Marcuello
  • M Virtudes Céspedes
  • France Docquier
  • Igor Chernukhin
  • Joaquin Navascues
  • Eva Ceballos
  • Pilar Gutierrez
  • David Matallanas
  • Gabriel Capella
  • M Carmen Lafita-Navarro
  • Kyle Sarnataro
  • Rocio Aguado
  • Cristina Ruiz-Herguido
  • Ana Batlle-López
  • Ignacio Varela
  • M Elisa Piedra
  • Dolors Colomer
  • Gema Moreno-Bueno
  • Arantza Onaindia
  • Miguel A Cortés
  • M Angeles Cuadrado
  • Vedrana Tabor
  • Miguel A Piris
  • Carlos Pipaon
  • Ana Batlle
  • Vikram Devgan
  • Laura Ceballos
  • M Jose Muñoz-Alonso
  • Manuel Rodríguez-Paredes
  • G Paolo Dotto
  • M Pilar Albero
  • Arancha Bermúdez
  • Paula Ruiz
  • Nicholas Donato
  • Ignacio Pérez-Roger
  • Carmen E Lopez-Jorge
  • Paolo Dotto
  • Axel Weber
  • Jorge Martin-Perez
  • Derya Donertas

Detail Information

Publications32

  1. ncbi request reprint Novel triiodophenol derivatives induce caspase-independent mitochondrial cell death in leukemia cells inhibited by Myc
    Matilde Parreño
    Departamento de Biologia Molecular, Facultad de Medicina, Universidad de Cantabria, Avenida Cardenal Herrera Oria, s n 39011 Santander, Cantabria, Spain
    Mol Cancer Ther 5:1166-75. 2006
    ..Bobels may serve as prototypes for the development of new agents for the therapy of leukemia...
  2. ncbi request reprint Inhibition of cell differentiation: a critical mechanism for MYC-mediated carcinogenesis?
    Javier Leon
    Departamento de Biologia Molecular, Facultad de Medicina, Instituto de Biomedicina y Biotecnología de Cantabria, Universidad de Cantabria CSIC IDICAN, Avda Cardenal Herrera Oria s n Santander, Spain
    Cell Cycle 8:1148-57. 2009
    ..We will discuss the hypothesis that MYC engages common pathways as a "stemness" keeper and as an oncogene...
  3. pmc Myc inhibits p27-induced erythroid differentiation of leukemia cells by repressing erythroid master genes without reversing p27-mediated cell cycle arrest
    Juan C Acosta
    Cancer Molecular Biology Group, Department of Molecular Biology, Instituto de Biomedicina y Biotecnología de Cantabria, Universidad de Cantabria CSIC IDICAN, Santander, Spain
    Mol Cell Biol 28:7286-95. 2008
    ..Our results support the hypothesis that differentiation inhibition is an important Myc tumorigenic mechanism that is independent of cell proliferation...
  4. ncbi request reprint Myc antagonizes Ras-mediated growth arrest in leukemia cells through the inhibition of the Ras-ERK-p21Cip1 pathway
    Jose P Vaque
    Grupo de Biología Molecular del Cáncer, Departamento de Biologia Molecular, Unidad de Biomedicina del Consejo Superior de Investigaciones Cientiíficas, Facultad de Medicina, Universidad de Cantabria, 39011 Santander, Spain
    J Biol Chem 280:1112-22. 2005
    ..The data suggest that in particular tumor types, such as those associated with CML, c-Myc contributes to tumorigenesis by inhibiting Ras antiproliferative activity...
  5. doi request reprint MYC in chronic myeloid leukemia: induction of aberrant DNA synthesis and association with poor response to imatinib
    Marta Albajar
    Departamento de Biologia Molecular, Facultad de Medicina, Instituto de Biomedicina y Biotecnología de Cantabria, Avda Cardenal Herrera Oria s n, 39011 Santander, Spain
    Mol Cancer Res 9:564-76. 2011
    ....
  6. ncbi request reprint Amifostine impairs p53-mediated apoptosis of human myeloid leukemia cells
    Juan C Acosta
    Grupo de Biología Molecular del Cáncer, Departamento de Biologia Molecular, Unidad de Biomedicina CSIC, Universidad de Cantabria, Santander, Spain
    Mol Cancer Ther 2:893-900. 2003
    ..Our results open the possibility that amifostine could reduce the effectiveness of antitumoral treatments when it is dependent on active p53...
  7. doi request reprint c-Myc inhibits Ras-mediated differentiation of pheochromocytoma cells by blocking c-Jun up-regulation
    Jose P Vaque
    Grupo de Biología Molecular del Cáncer, Dpto de Biología Molecular and Instituto de Biomedicina y Biotecnología de Cantabria, Universidad de Cantabria CSIC IDICAN, Santander, Spain
    Mol Cancer Res 6:325-39. 2008
    ..In conclusion, we describe a novel interplay between c-Myc and c-Jun that controls the ability of Ras to trigger the differentiation program of pheochromocytoma cells...
  8. pmc SKP2 oncogene is a direct MYC target gene and MYC down-regulates p27(KIP1) through SKP2 in human leukemia cells
    Gabriel Bretones
    Departamento de Biologia Molecular, Instituto de Biomedicina y Biotecnología de Cantabria, Universidad de Cantabria, Consejo Superior de Investigaciones Cientificas, SODERCAN Sociedad para el Desarrollo de Cantabria, 39011 Santander, Spain
    J Biol Chem 286:9815-25. 2011
    ..Our data show that SKP2 is a direct MYC target gene and that MYC-mediated SKP2 induction leads to reduced p27 levels. The results suggest the induction of SKP2 oncogene as a new mechanism for MYC-dependent transformation...
  9. ncbi request reprint Targeting of CTCF to the nucleolus inhibits nucleolar transcription through a poly(ADP-ribosyl)ation-dependent mechanism
    Verónica Torrano
    Grupo de Biología Molecular del Cáncer, Departamento de Biologia Molecular, Universidad de Cantabria, 39011 Santander, Spain
    J Cell Sci 119:1746-59. 2006
    ..Notably, the labelling of active transcription sites by in situ run-on assays demonstrated that CTCF inhibits nucleolar transcription through a poly(ADP-ribosyl)ation-dependent mechanism...
  10. pmc p21 as a transcriptional co-repressor of S-phase and mitotic control genes
    Nuria Ferrandiz
    Departamento de Biologia Molecular, Instituto de Biomedicina y Biotecnología de Cantabria IBBTEC, Universidad de Cantabria CSIC SODERCAN, Santander, Spain
    PLoS ONE 7:e37759. 2012
    ..Thus, p21 activity as inhibitor of cell cycle progression would be mediated not only by the inhibition of CDKs but also by the transcriptional down-regulation of key genes...
  11. ncbi request reprint Mitogen-activated protein kinase routes as targets in the action of diaza-anthracene compounds with a potent growth-inhibitory effect on cancer cells
    Carlos Pipaon
    Departamento de Biologia Molecular, Facultad de Medicina, Universidad de Cantabria, Unidad Asociada al CIB CSIC, 39011 Santander, Spain
    Mol Cancer Ther 1:811-9. 2002
    ....
  12. doi request reprint HCT116 cells deficient in p21(Waf1) are hypersensitive to tyrosine kinase inhibitors and adriamycin through a mechanism unrelated to p21 and dependent on p53
    Nuria Ferrandiz
    Dpto De Biologia Molecular, Instituto de Biomedicina y Biotecnología de Cantabria, Universidad de Cantabria CSIC IDICAN, Santander, Spain
    DNA Repair (Amst) 8:390-9. 2009
    ..Therefore the role of p21 on apoptosis of HCT116 colon cancer cells should be re-evaluated...
  13. doi request reprint p21(Cip1) confers resistance to imatinib in human chronic myeloid leukemia cells
    Nuria Ferrandiz
    Departamento de Biologia Molecular, Facultad de Medicina, Instituto de Biomedicina y Biotecnología de Cantabria, Universidad de Cantabria CSIC IDICAN, Santander, Spain
    Cancer Lett 292:133-9. 2010
    ..The results suggest an involvement of p21(Cip1) in the response to imatinib in CML...
  14. ncbi request reprint p21Cip1 and p27Kip1 induce distinct cell cycle effects and differentiation programs in myeloid leukemia cells
    Maria J Munoz-Alonso
    Grupo de Biología Molecular del Cáncer, Departamento de Biología Molecular y Unidad de Biomedicina Consejo Superior de Investigaciones Científicas, Universidad de Cantabria, 39011 Santander, Spain
    J Biol Chem 280:18120-9. 2005
    ....
  15. pmc High p27 protein levels in chronic lymphocytic leukemia are associated to low Myc and Skp2 expression, confer resistance to apoptosis and antagonize Myc effects on cell cycle
    Juan M Caraballo
    Instituto de Biomedicina y Biotecnología de Cantabria IBBTEC, CSIC Universidad de Cantabria SODERCAN, and Dpt of Biología Molecular, Universidad de Cantabria, Santander, Spain
    Oncotarget 5:4694-708. 2014
    ..Our data suggest that the combination of high p27 and low Myc is a marker of CLL cells which is mediated by Skp2. ..
  16. ncbi request reprint CTCF regulates growth and erythroid differentiation of human myeloid leukemia cells
    Verónica Torrano
    Grupo de Biología Molecular del Cáncer, Departamento de Biologia Molecular, Unidad de Biomedicina CSIC, Universidad de Cantabria, 39011 Santander, Spain
    J Biol Chem 280:28152-61. 2005
    ..Taken together our results demonstrate that CTCF is involved in the control of myeloid cell growth and differentiation...
  17. doi request reprint MYC accelerates p21CIP-induced megakaryocytic differentiation involving early mitosis arrest in leukemia cells
    Maria J Munoz-Alonso
    Departamento de Biologia Molecular, Universidad de Cantabria, Santander, Spain
    J Cell Physiol 227:2069-78. 2012
    ..Our data suggests that in some systems p21(CIP) takes part in a mitosis control driving MYC-induced cellular growth into differentiation...
  18. doi request reprint PU.1 expression is restored upon treatment of chronic myeloid leukemia patients
    Marta Albajar
    Departamento de Biología Molecular and Instituto de Biomedicina y Biotecnología de Cantabria IBBTEC, Universidad de Cantabria CSIC IDICAN, Facultad de Medicina, 39011 Santander, Spain
    Cancer Lett 270:328-36. 2008
    ..These effects are not found in patients with other myeloproliferative diseases such as polycythemia vera or essential thrombocythemia. PU.1 could, therefore, be used as an additional marker of the response to the treatment of the CML...
  19. pmc Sin3b interacts with Myc and decreases Myc levels
    Pablo García-Sanz
    From the Instituto de Biomedicina y Biotecnología de Cantabria IBBTEC, Consejo Superior de Investigaciones Cientificas, Universidad de Cantabria, Sociedad para el Desarrollo de Cantabria and the Departamento de Biología Molecular, Universidad de Cantabria, Santander 39011, Spain, the Instituto de Investigaciones Biomédicas Alberto Sols, Consejo Superior de Investigaciones Cientificas, Instituto de Investigación Hospital Universitario La Paz IdiPAZ, Facultad de Medicina, Universidad Autonoma de Madrid, 28046 Madrid, Spain, the Fundación M D Anderson Internacional, Madrid, Spain
    J Biol Chem 289:22221-36. 2014
    ....
  20. ncbi request reprint c-Myc overexpression increases cell size and impairs cartilage differentiation during chick limb development
    M Elisa Piedra
    Departamento de Anatomia y Biologia Celular, Universidad de Cantabria, 39011 Santander, Spain
    Cell Growth Differ 13:185-93. 2002
    ..Although based on overexpression experiments, our results suggest that endogenous c-Myc may be implicated in the control of cell size and skeletal differentiation during normal limb development...
  21. ncbi request reprint Inhibitory effect of c-Myc on p53-induced apoptosis in leukemia cells. Microarray analysis reveals defective induction of p53 target genes and upregulation of chaperone genes
    Eva Ceballos
    Departamento de Biología Molecular y Unidad de Biomedicina CSIC, Grupo de Biología Molecular del Cáncer, Facultad de Medicina, University of Cantabria, Santander 39011, Spain
    Oncogene 24:4559-71. 2005
    ..Our data suggest that elevated levels of Myc counteract p53 activity in human tumor cells that lack ARF. This mechanism could contribute to explain the c-Myc deregulation frequently found in cancer...
  22. doi request reprint Myc and cell cycle control
    Gabriel Bretones
    Instituto de Biomedicina y Biotecnología de Cantabria IBBTEC, CSIC Universidad de Cantabria SODERCAN and Departamento de Biología Molecular, Universidad de Cantabria, Santander, Spain
    Biochim Biophys Acta 1849:506-16. 2015
    ..This article is part of a Special Issue entitled: Myc proteins in cell biology and pathology. ..
  23. doi request reprint MYC oncogene in myeloid neoplasias
    M Dolores Delgado
    Group of Transcriptional Control and Cancer, Departamento de Biologia Molecular, Facultad de Medicina, Instituto de Biomedicina y Biotecnología de Cantabria IBBTEC, Universidad de Cantabria, CSIC, SODERCAN, Avda Cardenal Herrera Oria s n, 39011, Santander, Spain
    Clin Transl Oncol 15:87-94. 2013
    ..Here, we review the recent literature describing the involvement of MYC in myeloid tumors...
  24. doi request reprint NUMB inactivation confers resistance to imatinib in chronic myeloid leukemia cells
    Eva García-Alegría
    Instituto de Biomedicina y Biotecnología de Cantabria IBBTEC, CSIC Universidad de Cantabria and Dpto de Biología Molecular, Universidad de Cantabria, Santander, Spain
    Cancer Lett 375:92-9. 2016
    ..Taken together, our data support the hypothesis that NUMB activation could be a new therapeutic target in CML. ..
  25. ncbi request reprint Subcellular localization determines the protective effects of activated ERK2 against distinct apoptogenic stimuli in myeloid leukemia cells
    Nuria Ajenjo
    Departamento de Biologia Molecular, Unidad de Biomedicina de la Universidad de Cantabria CSIC, Santander 39011, Spain
    J Biol Chem 279:32813-23. 2004
    ....
  26. pmc Myc roles in hematopoiesis and leukemia
    M Dolores Delgado
    Departamento de Biologia Molecular, Facultad de Medicina and Instituto de Biomedicina y Biotecnología de Cantabria, Universidad de Cantabria CSIC, Santander, Spain
    Genes Cancer 1:605-16. 2010
    ....
  27. ncbi request reprint Kinetics of myc-max-mad gene expression during hepatocyte proliferation in vivo: Differential regulation of mad family and stress-mediated induction of c-myc
    Itsaso Mauleon
    Grupo de Biología Molecular del Cáncer, Departamento de Biología Molecular y Unidad de Biomedicina del CSIC, Facultad de Medicina, Universidad de Cantabria, Santander, Spain
    Mol Carcinog 39:85-90. 2004
    ..The results suggest nonredundant roles for mad genes in hepatocyte proliferation and point to c-Myc as a putative target for anticancer therapy of liver cancer...
  28. doi request reprint Bobel-24 and derivatives induce caspase-independent death in pancreatic cancer regardless of apoptotic resistance
    Matilde Parreño
    Grup d Oncogènesi i Antitumorals of the Networking Research Center on Bioengineering, Biomaterials and Nanomedicine, Institut de Recerca de l Hospital de la Santa Creu i Sant Pau, Barcelona, Spain
    Cancer Res 68:6313-23. 2008
    ..This mechanism may overcome the resistance to apoptosis observed in pancreatic carcinoma when treated with current genotoxic drugs...
  29. doi request reprint A celecoxib derivative inhibits focal adhesion signaling and induces caspase-8-dependent apoptosis in human acute myeloid leukemia cells
    Isolda Casanova
    Networking Research Center on Bioengineering, Biomaterials and Nanomedicine CIBER BBN, Barcelona, Spain
    Int J Cancer 123:217-26. 2008
    ..Finally, our results support the evaluation of celecoxib in AML patients, and the preclinical evaluation of E7123, before its possible clinical testing...
  30. ncbi request reprint K-ras Asp12 mutant neither interacts with Raf, nor signals through Erk and is less tumorigenic than K-ras Val12
    María Virtudes Céspedes
    Grup d Oncogenesi i Antitumorals, Institut de Recerca Hospital de la Santa Creu i Sant Pau HSCSP, Barcelona, Spain
    Carcinogenesis 27:2190-200. 2006
    ..Finally, the higher growth rate of the K12V tumors associates with enhanced Rb phosphorylation, and PCNA and cyclin B upregulation, consistent with faster G1/S and G2/M transitions, without alteration of apoptotic regulation...
  31. ncbi request reprint Celecoxib induces anoikis in human colon carcinoma cells associated with the deregulation of focal adhesions and nuclear translocation of p130Cas
    Isolda Casanova
    Laboratori d Investigació Gastrointestinal de l Institut de Recerca of the Hospital de la Santa Creu i Sant Pau, Barcelona, Spain
    Int J Cancer 118:2381-9. 2006
    ..Indeed, our results open the possibility to develop new celecoxib derivatives that induce anoikis without COX-2 inhibition so as to avoid the cardiovascular toxicity recently described for the COX-2 inhibitors...
  32. ncbi request reprint Heterotopic implantation alters the regulation of apoptosis and the cell cycle and generates a new metastatic site in a human pancreatic tumor xenograft model
    Lourdes Farre
    Institut de Recerca, Department of Surgery of the Hospital de la Santa Creu i Sant Pau, Barcelona, Spain
    FASEB J 16:975-82. 2002
    ..We also observed that implantation site alters the metastatic pattern of the NP9 tumor, originating a new metastatic site...