Gorka Larrinaga

Summary

Affiliation: University of the Basque Country
Country: Spain

Publications

  1. doi request reprint Increased prolyl endopeptidase activity in human neoplasia
    Gorka Larrinaga
    Department of Physiology, School of Medicine and Dentistry, Leioa, Bizkaia, Spain
    Regul Pept 163:102-6. 2010
  2. ncbi request reprint Altered glutamyl-aminopeptidase activity and expression in renal neoplasms
    Lorena Blanco
    Department of Physiology, Faculty of Medicine and Dentistry, Universitiy of the Basque Country UPV EHU, Leioa, Bizkaia, Spain
    BMC Cancer 14:386. 2014
  3. doi request reprint Prolyl endopeptidase activity is correlated with colorectal cancer prognosis
    Gorka Larrinaga
    1 Department of Nursing I, School of Nursing, University of the Basque Country UPV EHU, Leioa, Bizkaia, Spain 2 Department of Physiology, Faculty of Medicine and Dentistry, University of the Basque Country UPV EHU, Leioa, Bizkaia, Spain 6 BioCruces Health Research Institute, Barakaldo, Bizkaia, Spain
    Int J Med Sci 11:199-208. 2014
  4. doi request reprint Clinical impact of aspartyl aminopeptidase expression and activity in colorectal cancer
    Gorka Larrinaga
    Department of Nursing I, School of Nursing, University of the Basque Country UPV EHU, Leioa, Bizkaia, Spain Department of Physiology, Faculty of Medicine and Dentistry, University of the Basque Country UPV EHU, Leioa, Bizkaia, Spain BioCruces Health Research Institute, Barakaldo, Bizkaia, Spain Electronic address
    Transl Res 162:297-308. 2013
  5. doi request reprint Cannabinoid CB1 receptor is expressed in chromophobe renal cell carcinoma and renal oncocytoma
    Gorka Larrinaga
    Department of Physiology, Faculty of Medicine and Dentistry, University of the Basque Country UPV EHU, Leioa, Bizkaia, Spain
    Clin Biochem 46:638-41. 2013
  6. doi request reprint Angiotensin-converting enzymes (ACE and ACE2) are downregulated in renal tumors
    Gorka Larrinaga
    Department of Physiology, Faculty of Medicine and Dentistry, University of the Basque Country, Bilbao, Biscay, Spain
    Regul Pept 165:218-23. 2010
  7. ncbi request reprint Expression of cannabinoid receptors in human kidney
    Gorka Larrinaga
    Department of Physiology, Faculty of Medicine and Dentistry, University of the Basque Country UPV EHU, Leioa, Bizkaia, Spain
    Histol Histopathol 25:1133-8. 2010
  8. ncbi request reprint Cystinyl aminopeptidase activity is decreased in renal cell carcinomas
    Gorka Larrinaga
    Department of Nursing I, University of the Basque Country, Leioa, Bizkaia, Spain
    Regul Pept 144:56-61. 2007
  9. pmc Expression and activity profiles of DPP IV/CD26 and NEP/CD10 glycoproteins in the human renal cancer are tumor-type dependent
    Adolfo Varona
    Department of Physiology, Faculty of Medicine and Dentistry, University of Basque Country, Barrio Sarriena s n, 48940 Leioa, Spain
    BMC Cancer 10:193. 2010
  10. pmc Altered peptidase activities in thyroid neoplasia and hyperplasia
    Gorka Larrinaga
    Department of Nursing I, University School of Nursing, University of the Basque Country, P O Box 699, 48080 Bilbao, Bizkaia, Spain Department of Physiology, Faculty of Medicine and Dentistry, University of the Basque Country, Bilbao, Spain BioCruces Research Institute, Spain
    Dis Markers 35:825-32. 2013

Collaborators

Detail Information

Publications22

  1. doi request reprint Increased prolyl endopeptidase activity in human neoplasia
    Gorka Larrinaga
    Department of Physiology, School of Medicine and Dentistry, Leioa, Bizkaia, Spain
    Regul Pept 163:102-6. 2010
    ..Both cytosolic and membrane-bound PEP activity were also increased in colorectal adenomatous polyps. These data suggest the involvement of PEP in some mechanisms that underlie neoplastic processes...
  2. ncbi request reprint Altered glutamyl-aminopeptidase activity and expression in renal neoplasms
    Lorena Blanco
    Department of Physiology, Faculty of Medicine and Dentistry, Universitiy of the Basque Country UPV EHU, Leioa, Bizkaia, Spain
    BMC Cancer 14:386. 2014
    ..Glutamyl-aminopeptidase (GAP) (EC. 3.4.11.7) is a zinc metallopeptidase with angiotensinase activity highly expressed in kidney tissues and its expression and activity have been associated wtih tumour development...
  3. doi request reprint Prolyl endopeptidase activity is correlated with colorectal cancer prognosis
    Gorka Larrinaga
    1 Department of Nursing I, School of Nursing, University of the Basque Country UPV EHU, Leioa, Bizkaia, Spain 2 Department of Physiology, Faculty of Medicine and Dentistry, University of the Basque Country UPV EHU, Leioa, Bizkaia, Spain 6 BioCruces Health Research Institute, Barakaldo, Bizkaia, Spain
    Int J Med Sci 11:199-208. 2014
    ..However, there are no available data about the impact of this peptidase in the biological aggressiveness of this tumor in patient survival...
  4. doi request reprint Clinical impact of aspartyl aminopeptidase expression and activity in colorectal cancer
    Gorka Larrinaga
    Department of Nursing I, School of Nursing, University of the Basque Country UPV EHU, Leioa, Bizkaia, Spain Department of Physiology, Faculty of Medicine and Dentistry, University of the Basque Country UPV EHU, Leioa, Bizkaia, Spain BioCruces Health Research Institute, Barakaldo, Bizkaia, Spain Electronic address
    Transl Res 162:297-308. 2013
    ..Data suggest that ASP is involved in colorectal neoplasia and point to this enzyme as a potential useful diagnostic tool in clinical practice. ..
  5. doi request reprint Cannabinoid CB1 receptor is expressed in chromophobe renal cell carcinoma and renal oncocytoma
    Gorka Larrinaga
    Department of Physiology, Faculty of Medicine and Dentistry, University of the Basque Country UPV EHU, Leioa, Bizkaia, Spain
    Clin Biochem 46:638-41. 2013
    ..To analyze the mRNA and protein expression of cannabinoid receptors CB1 and CB2 in chromophobe renal cell carcinoma (ChRCC) and renal oncocytoma (RO)...
  6. doi request reprint Angiotensin-converting enzymes (ACE and ACE2) are downregulated in renal tumors
    Gorka Larrinaga
    Department of Physiology, Faculty of Medicine and Dentistry, University of the Basque Country, Bilbao, Biscay, Spain
    Regul Pept 165:218-23. 2010
    ..These findings suggest a metabolic imbalance in iRAS and a role of this system in renal neoplastic diseases, and point to ACE and ACE2 as potential prognostic/diagnostic markers...
  7. ncbi request reprint Expression of cannabinoid receptors in human kidney
    Gorka Larrinaga
    Department of Physiology, Faculty of Medicine and Dentistry, University of the Basque Country UPV EHU, Leioa, Bizkaia, Spain
    Histol Histopathol 25:1133-8. 2010
    ..Conversely, the CB2 cannabinoid receptor protein was consistently negative in all cases. Our data suggest a possible implication of the endocannabinoid system in the physiology and development of the human kidney...
  8. ncbi request reprint Cystinyl aminopeptidase activity is decreased in renal cell carcinomas
    Gorka Larrinaga
    Department of Nursing I, University of the Basque Country, Leioa, Bizkaia, Spain
    Regul Pept 144:56-61. 2007
    ..These data may open additional possibilities in the study of renal cell carcinoma with regard to the prognosis of patients...
  9. pmc Expression and activity profiles of DPP IV/CD26 and NEP/CD10 glycoproteins in the human renal cancer are tumor-type dependent
    Adolfo Varona
    Department of Physiology, Faculty of Medicine and Dentistry, University of Basque Country, Barrio Sarriena s n, 48940 Leioa, Spain
    BMC Cancer 10:193. 2010
    ..In the present study, the activity and protein and mRNA expression of these glycoproteins were analysed in a subset of clear-cell (CCRCC) and chromophobe (ChRCC) renal cell carcinomas, and in renal oncocytomas (RO)...
  10. pmc Altered peptidase activities in thyroid neoplasia and hyperplasia
    Gorka Larrinaga
    Department of Nursing I, University School of Nursing, University of the Basque Country, P O Box 699, 48080 Bilbao, Bizkaia, Spain Department of Physiology, Faculty of Medicine and Dentistry, University of the Basque Country, Bilbao, Spain BioCruces Research Institute, Spain
    Dis Markers 35:825-32. 2013
    ..However, very little is known about the involvement of other peptidases in neoplastic and hyperplastic processes of this gland...
  11. ncbi request reprint Altered levels of acid, basic, and neutral peptidase activity and expression in human clear cell renal cell carcinoma
    Adolfo Varona
    Dept of Physiology, Faculty of Medicine and Dentistry, Hospital de Basurto, University of the Basque Country, E 48080 Bilbao, Bizkaia, Spain
    Am J Physiol Renal Physiol 292:F780-8. 2007
    ..3-fold). This peptidase activity profile in the neoplastic kidney suggests a specific role for the studied convertases and the possible involvement of an intracrine renin-angiotensin system in the pathogenesis of CCRCC...
  12. doi request reprint Activity of soluble aminopeptidase A and dipeptidyl peptidase IV and membrane-bound aminopeptidase B and pyroglutamyl peptidase I in adenoid hyperplasia, tonsillar hyperplasia and chronic tonsillitis
    Gorka Larrinaga
    Department of Physiology, School of Medicine, University of the Basque Country, Spain
    Int J Pediatr Otorhinolaryngol 75:1399-403. 2011
    ..To analyze soluble and membrane-bound peptidase activities in the tonsils and adenoids removed from patients with adenoid hyperplasia, tonsillar hyperplasia and chronic tonsillitis...
  13. pmc Cannabinoid CB₁ receptor is downregulated in clear cell renal cell carcinoma
    Gorka Larrinaga
    Department of Physiology, Faculty of Medicine and Dentistry, University of the Basque Country, Universidad del Pais Vasco Euskal Herriko Unibertsitatea UPV EHU, Leioa, Bizkaia, Spain
    J Histochem Cytochem 58:1129-34. 2010
    ..The obtained data suggest a possible implication of the endocannabinoid system in renal carcinogenesis. A posttranscriptional downregulation of CB₁ and the absence of expression of CB₂ characterize CCRCC...
  14. doi request reprint The impact of peptidase activity on clear cell renal cell carcinoma survival
    Gorka Larrinaga
    Dept of Pathology, Hospital Universitario Cruces, Plaza de Cruces s n, Bizkaia, Spain
    Am J Physiol Renal Physiol 303:F1584-91. 2012
    ..Our data suggest the involvement of peptidases in the biological aggressiveness of CCRCC and support the usefulness of measuring these proteases to assess the prognosis of patients with CCRCC...
  15. ncbi request reprint Changes in cell-surface peptidase activity in papillary renal cell carcinoma
    Lorena Blanco
    Department of Physiology, Faculty of Medicine and Dentistry, University of the Basque Country, Barrio Sarriena, Leioa, Spain
    Anticancer Res 30:1137-41. 2010
    ..Peptidases are proteolytic enzymes known to be involved in oncological processes, although their precise role in renal cancer is poorly understood...
  16. doi request reprint Increased APN/CD13 and acid aminopeptidase activities in head and neck squamous cell carcinoma
    Itxaro Perez
    Department of Physiology, School of Medicine and Dentistry, University of the Basque Country, Bilbao, Spain
    Head Neck 31:1335-40. 2009
    ..However, very little is known about involvement of peptidases in this neoplasm...
  17. doi request reprint Acid, basic, and neutral peptidases present different profiles in chromophobe renal cell carcinoma and in oncocytoma
    Lorena Blanco
    Dept of Physiology, Faculty of Medicine and Dentistry, Univ of the Basque Country, P O Box 699, E 48080 Bilbao, Bizkaia, Spain
    Am J Physiol Renal Physiol 294:F850-8. 2008
    ..These results may suggest an involvement of several peptidases in the pathophysiology of renal cancer, since they presented different patterns of activity and expression in tumors with different behaviors...
  18. ncbi request reprint Subcellular distribution of membrane-bound aminopeptidases in the human and rat brain
    Gorka Larrinaga
    Department of Nursing I, University of the Basque Country, Bilbao, Bizkaia, Spain
    Neurosci Lett 383:136-40. 2005
    ..Moreover, these peptidases may play specific roles depending on their activity levels at the different subcellular structures where they are localized...
  19. doi request reprint Altered dipeptidyl peptidase IV and prolyl endopeptidase activities in chronic tonsillitis, tonsillar hyperplasia and adenoid hyperplasia
    Gorka Larrinaga
    Department of Physiology, University of the Basque Country, Bilbao, Spain
    Int J Pediatr Otorhinolaryngol 75:347-50. 2011
    ..To analyse peptidase activities in the removed tonsils and adenoids from patients with chronic tonsillitis, tonsillar hyperplasia and adenoid hyperplasia...
  20. ncbi request reprint Distribution of prolyl endopeptidase activities in rat and human brain
    Jon Irazusta
    Department of Physiology, Medical School, University of the Basque Country, Leioa, P O Box 699, 48, 080 Bilbao, Spain
    Neurochem Int 40:337-45. 2002
    ..The particulate form was enriched in the synaptosomal and the myelinic membranes. The high activity of prolyl endopeptidase in the human cortex suggests that prolyl endopeptidase could play a role in the functions of this brain area...
  21. doi request reprint Targeted next-generation sequencing and non-coding RNA expression analysis of clear cell papillary renal cell carcinoma suggests distinct pathological mechanisms from other renal tumour subtypes
    Charles H Lawrie
    Oncology Area, Biodonostia Research Institute, San Sebastian, Spain Nuffield Department of Clinical Laboratory Sciences, University of Oxford, UK IKERBASQUE, Basque Foundation for Science, Bilbao, Spain
    J Pathol 232:32-42. 2014
    ..Microarray data have been deposited in the GEO database [GEO accession number (GSE51554)]...
  22. ncbi request reprint Effects of morphine administration and its withdrawal on rat brain aminopeptidase activities
    Jon Irazusta
    Department of Physiology, Faculty of Medicine, University of the Basque Country, P O Box 699, Vizcaya E 48080, Bilbao, Spain
    Regul Pept 110:225-30. 2003
    ..The results of the present report indicate that aminopeptidases may play an important role in the processes of tolerance and withdrawal associated with morphine administration...