Esther Larrea

Summary

Affiliation: University of Navarra
Country: Spain

Publications

  1. doi request reprint Characterization of the CD40L/Oncostatin M/Oncostatin M receptor axis as an antiviral and immunostimulatory system disrupted in chronic HCV infection
    Esther Larrea
    Division of Hepatology and Gene Therapy, Center for Applied Medical Research CIMA, University of Navarra, Pamplona, Spain Electronic address
    J Hepatol 60:482-9. 2014
  2. pmc Oncostatin M enhances the antiviral effects of type I interferon and activates immunostimulatory functions in liver epithelial cells
    Esther Larrea
    Division of Hepatology and Gene Therapy, Center for Applied Medical Research, University of Navarra, Pamplona, Spain
    J Virol 83:3298-311. 2009
  3. doi request reprint Hepatitis C virus induces the expression of CCL17 and CCL22 chemokines that attract regulatory T cells to the site of infection
    Jose Ignacio Riezu-Boj
    Gene Therapy and Hepatology Area, Center for Applied Medical Research CIMA, University of Navarra, Pamplona, Spain
    J Hepatol 54:422-31. 2011
  4. doi request reprint Anchoring interferon alpha to apolipoprotein A-I reduces hematological toxicity while enhancing immunostimulatory properties
    Jessica Fioravanti
    Division of Hepatology and Gene Therapy, Center for Applied Medical Research, University of Navarra, Pamplona, Navarra, Spain
    Hepatology 53:1864-73. 2011
  5. ncbi request reprint Dysregulation of interferon regulatory factors impairs the expression of immunostimulatory molecules in hepatitis C virus genotype 1-infected hepatocytes
    Esther Larrea
    Division of Hepatology and Gene Therapy, Center for Applied Medical Research CIMA, Pamplona, Spain
    Gut 63:665-73. 2014
  6. doi request reprint A clinical trial of CTLA-4 blockade with tremelimumab in patients with hepatocellular carcinoma and chronic hepatitis C
    Bruno Sangro
    Liver Unit and HPB Oncology, Clinica Universidad de Navarra, Pamplona, Spain
    J Hepatol 59:81-8. 2013
  7. ncbi request reprint Hepatitis C virus infection of primary tupaia hepatocytes leads to selection of quasispecies variants, induction of interferon-stimulated genes and NF-kappaB nuclear translocation
    Anunciata Guitart
    Division of Hepatology and Gene Therapy, Clinica Universitaria and School of Medicine, Centre for Applied Medical Research CIMA, University of Navarra, Pamplona, Spain
    J Gen Virol 86:3065-74. 2005
  8. ncbi request reprint CD8 T cell priming in the presence of IFN-α renders CTLs with improved responsiveness to homeostatic cytokines and recall antigens: important traits for adoptive T cell therapy
    Sandra Hervas-Stubbs
    Division of Gene Therapy and Hepatology, Center for Applied Medical Research, University of Navarra, Pamplona 31008, Spain
    J Immunol 189:3299-310. 2012
  9. ncbi request reprint IFN-alpha5 mediates stronger Tyk2-stat-dependent activation and higher expression of 2',5'-oligoadenylate synthetase than IFN-alpha2 in liver cells
    Esther Larrea
    Division of Hepatology and Gene Therapy, Clinica Universitaria School of Medicine, Center for Applied Medical Research CIMA University of Navarra, Spain
    J Interferon Cytokine Res 24:497-503. 2004
  10. doi request reprint Effects of IFN-α as a signal-3 cytokine on human naïve and antigen-experienced CD8(+) T cells
    Sandra Hervas-Stubbs
    Division of Gene Therapy and Hepatology, Centre for Applied Medical Research CIMA, University of Navarra, Pamplona, Spain
    Eur J Immunol 40:3389-402. 2010

Collaborators

Detail Information

Publications24

  1. doi request reprint Characterization of the CD40L/Oncostatin M/Oncostatin M receptor axis as an antiviral and immunostimulatory system disrupted in chronic HCV infection
    Esther Larrea
    Division of Hepatology and Gene Therapy, Center for Applied Medical Research CIMA, University of Navarra, Pamplona, Spain Electronic address
    J Hepatol 60:482-9. 2014
    ..Here we have analysed OSM and its receptors in livers with chronic hepatitis C (CHC) and studied the factors that regulate this system...
  2. pmc Oncostatin M enhances the antiviral effects of type I interferon and activates immunostimulatory functions in liver epithelial cells
    Esther Larrea
    Division of Hepatology and Gene Therapy, Center for Applied Medical Research, University of Navarra, Pamplona, Spain
    J Virol 83:3298-311. 2009
    ..In conclusion, OSM enhances the antiviral effects of type I interferon and cooperates with it in the induction of adaptive immune responses to pathogens. These findings may have therapeutic implications...
  3. doi request reprint Hepatitis C virus induces the expression of CCL17 and CCL22 chemokines that attract regulatory T cells to the site of infection
    Jose Ignacio Riezu-Boj
    Gene Therapy and Hepatology Area, Center for Applied Medical Research CIMA, University of Navarra, Pamplona, Spain
    J Hepatol 54:422-31. 2011
    ..The mechanisms by which Foxp3+ T regulatory cells (Treg) accumulate in HCV infected livers are not known. Here, we studied the role of chemokines CCL17 and CCL22 in this process...
  4. doi request reprint Anchoring interferon alpha to apolipoprotein A-I reduces hematological toxicity while enhancing immunostimulatory properties
    Jessica Fioravanti
    Division of Hepatology and Gene Therapy, Center for Applied Medical Research, University of Navarra, Pamplona, Navarra, Spain
    Hepatology 53:1864-73. 2011
    ....
  5. ncbi request reprint Dysregulation of interferon regulatory factors impairs the expression of immunostimulatory molecules in hepatitis C virus genotype 1-infected hepatocytes
    Esther Larrea
    Division of Hepatology and Gene Therapy, Center for Applied Medical Research CIMA, Pamplona, Spain
    Gut 63:665-73. 2014
    ..IL-7 and IL-15 are produced by hepatocytes and are critical for the expansion and function of CD8 T cells. IL-15 needs to be presented by IL-15Rα for efficient stimulation of CD8 T cells...
  6. doi request reprint A clinical trial of CTLA-4 blockade with tremelimumab in patients with hepatocellular carcinoma and chronic hepatitis C
    Bruno Sangro
    Liver Unit and HPB Oncology, Clinica Universidad de Navarra, Pamplona, Spain
    J Hepatol 59:81-8. 2013
    ....
  7. ncbi request reprint Hepatitis C virus infection of primary tupaia hepatocytes leads to selection of quasispecies variants, induction of interferon-stimulated genes and NF-kappaB nuclear translocation
    Anunciata Guitart
    Division of Hepatology and Gene Therapy, Clinica Universitaria and School of Medicine, Centre for Applied Medical Research CIMA, University of Navarra, Pamplona, Spain
    J Gen Virol 86:3065-74. 2005
    ..In summary, HCV quasispecies adapt rapidly to the specific biology of the host and HCV stimulates a blunted interferon response while inducing a proinflammatory phenotype in the infected cell...
  8. ncbi request reprint CD8 T cell priming in the presence of IFN-α renders CTLs with improved responsiveness to homeostatic cytokines and recall antigens: important traits for adoptive T cell therapy
    Sandra Hervas-Stubbs
    Division of Gene Therapy and Hepatology, Center for Applied Medical Research, University of Navarra, Pamplona 31008, Spain
    J Immunol 189:3299-310. 2012
    ..Therefore, exposure to IFN-α during priming of naive CD8 T cells imprints decisive information on the expanded cells that can be exploited to improve the efficacy of adoptive T cell therapy...
  9. ncbi request reprint IFN-alpha5 mediates stronger Tyk2-stat-dependent activation and higher expression of 2',5'-oligoadenylate synthetase than IFN-alpha2 in liver cells
    Esther Larrea
    Division of Hepatology and Gene Therapy, Clinica Universitaria School of Medicine, Center for Applied Medical Research CIMA University of Navarra, Spain
    J Interferon Cytokine Res 24:497-503. 2004
    ..These data warrant clinical trials to evaluate the efficacy of IFN-alpha5 in chronic viral hepatitis...
  10. doi request reprint Effects of IFN-α as a signal-3 cytokine on human naïve and antigen-experienced CD8(+) T cells
    Sandra Hervas-Stubbs
    Division of Gene Therapy and Hepatology, Centre for Applied Medical Research CIMA, University of Navarra, Pamplona, Spain
    Eur J Immunol 40:3389-402. 2010
    ..Our findings in human CD8(+) T cells are informative to understand and improve IFN-α-based therapies for viral and malignant diseases...
  11. pmc Cardiotrophin-1 promotes a high survival rate in rabbits with lethal fulminant hepatitis of viral origin
    María Jesús Tuñón
    Division of Hepatology and Gene Therapy, Center for Applied Medical Research, and University Clinic, University of Navarra, Avda Pio XII 55, 31008 Pamplona, Navarra, Spain
    J Virol 85:13124-32. 2011
    ..In conclusion, in a lethal form of acute viral hepatitis, CT-1 increases animal survival by attenuating inflammation and activating cytoprotective mechanisms, thus representing a promising therapy for ALF of viral origin...
  12. ncbi request reprint HCV structural proteins interfere with interferon-alpha Jak/STAT signalling pathway
    Esther Luquin
    Division of Hepatology and Gene Therapy CIMA, University of Navarra, Pamplona, Spain
    Antiviral Res 76:194-7. 2007
    ..These results indicate that HCV structural proteins play an important role in the escape of HCV from the interferon system...
  13. pmc Upregulation of indoleamine 2,3-dioxygenase in hepatitis C virus infection
    Esther Larrea
    Division of Gene Therapy and Hepatology, Center for Applied Medical Research, CIMA, Avenida Pio XII 55, 31008 Pamplona, Spain
    J Virol 81:3662-6. 2007
    ..For both patients and chimpanzees, hepatic expression of IDO and CTLA-4 correlated directly. Induction of IDO may dampen T-cell reactivity to viral antigens in chronic HCV infection...
  14. ncbi request reprint Induction of immunosuppressive molecules and regulatory T cells counteracts the antitumor effect of interleukin-12-based gene therapy in a transgenic mouse model of liver cancer
    Maider Zabala
    Division of Hepatology and Gene Therapy, Center for Applied Medical Research CIMA, Spain
    J Hepatol 47:807-15. 2007
    ..In this work we aimed at evaluating the antitumor effect of interleukin-12 (IL-12)-based gene therapy on HCC occurring spontaneously in mice...
  15. ncbi request reprint Recombinant adenoviral vectors turn on the type I interferon system without inhibition of transgene expression and viral replication
    Eduardo Huarte
    Center for Applied Medical Research, School of Medicine, and University Clinic, University of Navarra, Avenida Pio XII, 55, 31008 Pamplona, Spain
    Mol Ther 14:129-38. 2006
    ..However, type I IFN might modulate antitumor and antiadenoviral immune responses and thus influence the outcome of gene immunotherapy...
  16. doi request reprint Improved dendritic cell-based immunization against hepatitis C virus using peptide inhibitors of interleukin 10
    Nancy Díaz-Valdés
    Division of Hepatology and Gene Therapy, Center for Applied Medical Research, University of Navarra, Pamplona, Spain
    Hepatology 53:23-31. 2011
    ..Finally, immunization with p13-treated murine DC induced stronger anti-HCV T-cell responses not only in wildtype mice but also in HCV transgenic mice and in mice transiently expressing HCV core in the liver...
  17. doi request reprint Dendritic cells adhere to and transmigrate across lymphatic endothelium in response to IFN-α
    Ana Rouzaut
    Center for Applied Medical Research, School of Medicine, University of Navarra, Pamplona, Spain
    Eur J Immunol 40:3054-63. 2010
    ..Collectively, these results indicate a role for type I IFN in directing DC toward LN under inflammatory conditions...
  18. doi request reprint Modulation of regulatory T-cell activity in combination with interleukin-12 increases hepatic tolerogenicity in woodchucks with chronic hepatitis B
    Itziar Otano
    Centro de Investigación Médica Aplicada CIMA, Division of Hepatology and Gene Therapy, University of Navarra, Pamplona, Spain
    Hepatology 56:474-83. 2012
    ..However, no antiviral effect was achieved and, instead, an enhancement of the intrahepatic tolerogenic environment was observed...
  19. doi request reprint Validation of an antiviral assay method for quantifying IFN-α5 activity in macaque and human serum
    Leire Arbillaga
    Toxicology Unit, Center for Applied Pharmacobiology Research, University of Navarra, Irunlarrea 1, E 31008 Pamplona, Spain
    Bioanalysis 5:289-305. 2013
    ..However, there is no specific and validated quantification method in order to conduct kinetic studies as part of the preclinical and clinical evaluation for regulatory purposes...
  20. ncbi request reprint Methylthioadenosine phosphorylase gene expression is impaired in human liver cirrhosis and hepatocarcinoma
    Carmen Berasain
    Division of Hepatology and Gene Therapy, CIMA, Facultad de Medicina, Universidad de Navarra 31008 Pamplona, Spain
    Biochim Biophys Acta 1690:276-84. 2004
    ..Given the recently proposed tumor suppressor activity of MTAP, our observations can be relevant to the elucidation of the molecular mechanisms of multistep hepatocarcinogenesis...
  21. pmc Characterization of the human Nalpha-terminal acetyltransferase B enzymatic complex
    Amagoia Ametzazurra
    Division of Hepatology and Gene Therapy, Center for Applied Medical Research CIMA, University of Navarra, Pamplona, Spain
    BMC Proc 3:S4. 2009
    ..This is achievable because it can acetylate a great number of peptides composed by an aspartic or glutamic acid at their second residue and therefore it can regulate the activity of a great number of proteins...
  22. pmc Usage of adenovirus expressing thymidine kinase mediated hepatocellular damage for enabling mouse liver repopulation with allogenic or xenogenic hepatocytes
    Daniel Moreno
    Gene Therapy and Hepatology Area, Center for Applied Medical Research CIMA, University of Navarra, Pamplona, Spain
    PLoS ONE 8:e74948. 2013
    ..This approach represents a simple alternative strategy for chimeric liver generation using immunodeficient mice without additional genetic manipulation of the germ line. ..
  23. ncbi request reprint The woodchuck interferon-alpha system: Cloning, family description, and biologic activity
    Pedro Berraondo
    Division of Hepatology and Gene Therapy, University Clinic and Medical School, University of Navarra, Pamplona, Spain
    J Med Virol 68:424-32. 2002
    ....