A Lanas

Summary

Affiliation: University of Zaragoza
Country: Spain

Publications

  1. ncbi Gastrointestinal injury from NSAID therapy. How to reduce the risk of complications
    Angel Lanas
    Service of Gastroenterology, University Hospital, Institute of Health Sciences of Aragon, Zaragoza, Spain
    Postgrad Med 117:23-8, 31. 2005
  2. ncbi Gastroprotection in NSAID and low-dose aspirin users: a cross-sectional study in primary care
    Angel Lanas
    Service of Digestive Diseases, University Hospital, University of Zaragoza, Instituto de Investigación Sanitaria de Aragón IIS Aragón, Centros de Investigación en Red de Enfermedades Hepáticas y Digestivas CIBERehd, Zaragoza, Spain
    Gastroenterol Hepatol 35:1-7. 2012
  3. doi Safe prescription recommendations for non steroidal anti-inflammatory drugs: consensus document ellaborated by nominated experts of three scientific associations (SER-SEC-AEG)
    Angel Lanas
    Servicio de Aparato Digestivo, Hospital Clinico Lozano Blesa, Universidad de Zaragoza, IIS Aragón, CIBERehd, Zaragoza, España Electronic address
    Reumatol Clin 10:68-84. 2014
  4. doi [Safe prescription recommendations for non steroidal anti-inflammatory drugs: Consensus document ellaborated by nominated experts of three scientific associations (SER-SEC-AEG)]
    Angel Lanas
    Servicio de Aparato Digestivo, Hospital Clinico Lozano Blesa, Universidad de Zaragoza, IIS Aragón, CIBERehd, Zaragoza, España Electronic address
    Gastroenterol Hepatol 37:107-27. 2014
  5. doi [Update on non-variceal gastrointestinal bleeding]
    Angel Lanas
    Servicio de Aparato Digestivo, Hospital Clinico Universitario Lozano Blesa, Universidad de Zaragoza, IIS Aragón, CIBERehd, Zaragoza, España Electronic address
    Gastroenterol Hepatol 36:57-65. 2013
  6. doi Effect of proton pump inhibitors on the outcomes of peptic ulcer bleeding: comparison of event rates in routine clinical practice and a clinical trial
    Angel Lanas
    Servicio de Aparato Digestivo, Hospital Clinico, Universidad de Zaragoza, IIS Aragón, Zaragoza, Spain
    Scand J Gastroenterol 48:285-94. 2013
  7. doi The aspirin cardiovascular/gastrointestinal risk calculator--a tool to aid clinicians in practice
    A Lanas
    Service of Digestive Diseases, University Hospital Lozano Blesa, University of Zaragoza, IIS Aragón, Spain
    Aliment Pharmacol Ther 37:738-48. 2013
  8. doi One year intermittent rifaximin plus fibre supplementation vs. fibre supplementation alone to prevent diverticulitis recurrence: a proof-of-concept study
    Angel Lanas
    Service of Digestive Diseases, University Hospital Lozano Blesa, IIS Aragón, CIBERehd, University of Zaragoza, Spain
    Dig Liver Dis 45:104-9. 2013
  9. doi [Gastrointestinal bleeding associated with NSAIDs, antiplatelet therapy and anticoagulant agent]
    Angel Lanas
    Servicio de Aparato Digestivo, Hospital Clinico Universitario Lozano Blesa, Universidad de Zaragoza, IIS Aragón, CIBERehd, Zaragoza, Spain
    Gastroenterol Hepatol 35:35-42. 2012
  10. doi [Advances in gastrointestinal disorders associated with non-steroidal antiinflammatory agents and aspirin]
    Angel Lanas
    Servicio de Aparato Digestivo, Hospital Clinico Universitario, Universidad de Zaragoza, IIS Aragón, Zaragoza, Espana
    Gastroenterol Hepatol 34:36-42. 2011

Detail Information

Publications110 found, 100 shown here

  1. ncbi Gastrointestinal injury from NSAID therapy. How to reduce the risk of complications
    Angel Lanas
    Service of Gastroenterology, University Hospital, Institute of Health Sciences of Aragon, Zaragoza, Spain
    Postgrad Med 117:23-8, 31. 2005
    ..In this article, Dr Lanas summarizes the GI risks associated with NSAID and low-dose aspirin therapy and weighs the efficacy of current risk management strategies...
  2. ncbi Gastroprotection in NSAID and low-dose aspirin users: a cross-sectional study in primary care
    Angel Lanas
    Service of Digestive Diseases, University Hospital, University of Zaragoza, Instituto de Investigación Sanitaria de Aragón IIS Aragón, Centros de Investigación en Red de Enfermedades Hepáticas y Digestivas CIBERehd, Zaragoza, Spain
    Gastroenterol Hepatol 35:1-7. 2012
    ..We also found high rates of gastroprotection use in LDA users...
  3. doi Safe prescription recommendations for non steroidal anti-inflammatory drugs: consensus document ellaborated by nominated experts of three scientific associations (SER-SEC-AEG)
    Angel Lanas
    Servicio de Aparato Digestivo, Hospital Clinico Lozano Blesa, Universidad de Zaragoza, IIS Aragón, CIBERehd, Zaragoza, España Electronic address
    Reumatol Clin 10:68-84. 2014
    ..We propose a patient management algorithm that summarizes the main aspects of the recommendations. ..
  4. doi [Safe prescription recommendations for non steroidal anti-inflammatory drugs: Consensus document ellaborated by nominated experts of three scientific associations (SER-SEC-AEG)]
    Angel Lanas
    Servicio de Aparato Digestivo, Hospital Clinico Lozano Blesa, Universidad de Zaragoza, IIS Aragón, CIBERehd, Zaragoza, España Electronic address
    Gastroenterol Hepatol 37:107-27. 2014
    ..We propose a patient management algorithm that summarizes the main aspects of the recommendations. ..
  5. doi [Update on non-variceal gastrointestinal bleeding]
    Angel Lanas
    Servicio de Aparato Digestivo, Hospital Clinico Universitario Lozano Blesa, Universidad de Zaragoza, IIS Aragón, CIBERehd, Zaragoza, España Electronic address
    Gastroenterol Hepatol 36:57-65. 2013
    ..Finally, there is evidence that both environmental and genetic factors are involved in individual susceptibility to gastrointestinal bleeding...
  6. doi Effect of proton pump inhibitors on the outcomes of peptic ulcer bleeding: comparison of event rates in routine clinical practice and a clinical trial
    Angel Lanas
    Servicio de Aparato Digestivo, Hospital Clinico, Universidad de Zaragoza, IIS Aragón, Zaragoza, Spain
    Scand J Gastroenterol 48:285-94. 2013
    ..v. esomeprazole...
  7. doi The aspirin cardiovascular/gastrointestinal risk calculator--a tool to aid clinicians in practice
    A Lanas
    Service of Digestive Diseases, University Hospital Lozano Blesa, University of Zaragoza, IIS Aragón, Spain
    Aliment Pharmacol Ther 37:738-48. 2013
    ..Assessment of both GI and CV risks vs. the benefits of low-dose aspirin for individual patients can be difficult in clinical practice...
  8. doi One year intermittent rifaximin plus fibre supplementation vs. fibre supplementation alone to prevent diverticulitis recurrence: a proof-of-concept study
    Angel Lanas
    Service of Digestive Diseases, University Hospital Lozano Blesa, IIS Aragón, CIBERehd, University of Zaragoza, Spain
    Dig Liver Dis 45:104-9. 2013
    ..Evidence supporting appropriate medical therapy to prevent recurrence of colonic diverticulitis is limited. Our goal was to evaluate the potential of rifaximin given periodically in addition to fibre for the prophylaxis of recurrences...
  9. doi [Gastrointestinal bleeding associated with NSAIDs, antiplatelet therapy and anticoagulant agent]
    Angel Lanas
    Servicio de Aparato Digestivo, Hospital Clinico Universitario Lozano Blesa, Universidad de Zaragoza, IIS Aragón, CIBERehd, Zaragoza, Spain
    Gastroenterol Hepatol 35:35-42. 2012
    ..Notable innovations are the development of a disposable endoscope for acute upper gastrointestinal bleeding events and a promising new hemostatic technique, hemospray, applied locally over the bleeding lesion...
  10. doi [Advances in gastrointestinal disorders associated with non-steroidal antiinflammatory agents and aspirin]
    Angel Lanas
    Servicio de Aparato Digestivo, Hospital Clinico Universitario, Universidad de Zaragoza, IIS Aragón, Zaragoza, Espana
    Gastroenterol Hepatol 34:36-42. 2011
    ....
  11. pmc CagA-positive Helicobacter pylori infection is not associated with decreased risk of Barrett's esophagus in a population with high H. pylori infection rate
    Angel Ferrandez
    Gastrointestinal Oncology Unit, Service of Digestive Diseases, Hospital Clinico Lozano Blesa, Zaragoza, Spain
    BMC Gastroenterol 6:7. 2006
    ..The role that H. pylori infection plays in the development of and Barrett's esophagus (BE) is uncertain. We tested the hypothesis that infection with cagA+ Helicobacter pylori strains protects against the development of BE...
  12. ncbi Effects of long-term cyclo-oxygenase 2 selective and acid inhibition on Barrett's oesophagus
    A Lanas
    Service of Digestive Diseases, University Hospital, Instituto Aragones de Ciencias de la Salud, CIBERehd, Zaragoza, Spain
    Aliment Pharmacol Ther 26:913-23. 2007
    ..There is an overexpression of cyclo-oxygenase 2 (COX-2) in Barrett's oesophagus (BO)...
  13. pmc Education-based approach to addressing non-evidence-based practice in preventing NSAID-associated gastrointestinal complications
    Angel Lanas
    Service of Digestive Diseases, University Hospital, University of Zaragoza, Instituto Aragonés de Ciencias de Salud, Centros de Investigación en Red de Enfermedades Hepáticas y Digestivas CIBERehd, C San Juan Bosco 15, 50009 Zaragoza, Spain
    World J Gastroenterol 15:5953-9. 2009
    ..To evaluate an evidence-based educational program for improving strategies for prevention of nonsteroidal anti-inflammatory drug (NSAID)-associated gastrointestinal (GI) complications...
  14. ncbi Inappropriate prevention of NSAID-induced gastrointestinal events among long-term users in the elderly
    Angel Lanas
    Service of Digestive Diseases, University Hospital, Instituto Aragones de Ciencias de la Salud CIBER HEPAD, University of Zaragoza, Zaragoza, Spain
    Drugs Aging 24:121-31. 2007
    ..In summary, aging is a key risk factor for GI complications in patients taking NSAIDs. Appropriate prevention strategies should be used in the elderly and those at risk; special attention should be paid to compliance and self-medication...
  15. ncbi [Chemoprevention in adenocarcinoma of the esophagus]
    Angel Lanas
    Servicio de Aparato Digestivo, Hospital Clinico Universitario, Zaragoza, Espana
    Acta Gastroenterol Latinoam 37:37-48. 2007
    ....
  16. ncbi Potent gastric acid inhibition in the management of Barrett's oesophagus
    Angel Lanas
    Gastroenterology Service, Clinical University Hospital, Zaragoza, Spain
    Drugs 65:75-82. 2005
    ..This therapeutic approach should be still regarded as experimental and more data are needed before its therapeutic role in patients with Barrett's oesophagus is established...
  17. ncbi [Prevention and treatment of non-steroidal anti-inflammatory drug gastroenteropathy]
    Angel Lanas
    Sección de Gastroenterología, Servicio de Aparato Digestivo, Hospital Clinico Universitario, Universidad de Zaragoza, Zaragoza, Espana
    Rev Gastroenterol Mex 69:251-60. 2004
    ..In patients at very high risk, co-prescription of coxib with proton pump inhibitors has been recommended. In patients at risk, all these strategies are cost-effective...
  18. doi Nonsteroidal antiinflammatory drugs and cyclooxygenase inhibition in the gastrointestinal tract: a trip from peptic ulcer to colon cancer
    Angel Lanas
    Service of Digestive Diseases, University Hospital, CIBERehd IACS, University of Zaragoza, Zaragoza, Spain
    Am J Med Sci 338:96-106. 2009
    ..New studies will have to define the appropriate population that may benefit with these therapies...
  19. ncbi Time trends and impact of upper and lower gastrointestinal bleeding and perforation in clinical practice
    Angel Lanas
    Servicio de Aparato Digestivo, Hospital Clinico, Universidad de Zaragoza, Zaragoza, Spain
    Am J Gastroenterol 104:1633-41. 2009
    ....
  20. ncbi Economic analysis of strategies in the prevention of non-steroidal anti-inflammatory drug-induced complications in the gastrointestinal tract
    A Lanas
    Service of Gastroenterology, Clinic University Hospital, Zaragoza, Spain
    Aliment Pharmacol Ther 20:321-31. 2004
    ..It is unclear what the best therapeutic approach is in patients who require non-steroidal anti-inflammatory drugs. In clinical practice, choice of prescriptions are often based on drug costs...
  21. doi Low doses of acetylsalicylic acid increase risk of gastrointestinal bleeding in a meta-analysis
    Angel Lanas
    Servicio de Aparato Digestivo, University of Zaragoza, IIS Aragón, CIBERehd, Spain
    Clin Gastroenterol Hepatol 9:762-768.e6. 2011
    ....
  22. pmc A review of the gastrointestinal safety data--a gastroenterologist's perspective
    Angel Lanas
    Servicio de Aparato Digestivo, Hospital Clinico Universitario, C San Juan Bosco 15, 50009 Zaragoza, Spain
    Rheumatology (Oxford) 49:ii3-10. 2010
    ..To facilitate such studies a new endpoint, Clinically Significant Upper or Lower GI Events, has been introduced that captures both upper and lower GI events...
  23. ncbi Assessment of gastrointestinal and cardiovascular risk in patients with osteoarthritis who require NSAIDs: the LOGICA study
    Angel Lanas
    Universidad de Zaragoza, Servicio de Aparato Digestivo, Hospital Clinico, CIBERehd, I CS, Zaragoza, Spain
    Ann Rheum Dis 69:1453-8. 2010
    ..Medical management of adults with osteoarthritis (OA) who require non-steroidal anti-inflammatory drugs (NSAIDs) must be decided after assessing prevalent gastrointestinal (GI) and cardiovascular (CV) risks in the individual patient...
  24. doi Nonsteroidal anti-inflammatory drugs and lower gastrointestinal complications
    Angel Lanas
    Service of Digestive Diseases, University Hospital, University of Zaragoza, Instituto Aragones de Ciencias de la Salud, CIBERehd, C San Juan Bosco 15, 50009 Zaragoza, Spain
    Gastroenterol Clin North Am 38:333-52. 2009
    ..Data from one ongoing trial comparing celecoxib versus diclofenac plus PPI and examining serious outcomes from the whole GI tract will probably provide new insights in this area...
  25. ncbi NSAID-induced gastrointestinal damage: current clinical management and recommendations for prevention
    Angel Lanas
    Service of Gastroenterology, University Hospital of Zaragoza, Spain
    Chin J Dig Dis 7:127-33. 2006
    ....
  26. pmc Risk of upper gastrointestinal ulcer bleeding associated with selective cyclo-oxygenase-2 inhibitors, traditional non-aspirin non-steroidal anti-inflammatory drugs, aspirin and combinations
    A Lanas
    Servicio de Aparato Digestivo, Hospital Clinico Universitario, Zaragoza 50009, Spain
    Gut 55:1731-8. 2006
    ..The risks and benefits of coxibs, non-steroidal anti-inflammatory drugs (NSAIDs), and aspirin treatment are under intense debate...
  27. pmc Short-term acetylsalicylic acid (aspirin) use for pain, fever, or colds - gastrointestinal adverse effects: a meta-analysis of randomized clinical trials
    Angel Lanas
    University of Zaragoza Medical School, Aragn Health Research Institute IIS Aragn, CIBERehd, Zaragoza, Spain
    Drugs R D 11:277-88. 2011
    ..The aim of this study was to provide data on the safety of this treatment pattern, which is of interest to clinicians, regulators, and the public...
  28. doi NSAIDs and the colon
    Angel Lanas
    Service of Digestive Diseases, University Hospital, CIBERehd IACS, University of Zaragoza, Zaragoza, Spain
    Curr Opin Gastroenterol 25:44-9. 2009
    ..To better understand the effects of NSAIDs on the colon...
  29. ncbi Microbial flora in NSAID-induced intestinal damage: a role for antibiotics?
    Angel Lanas
    Servicio de Aparato Digestivo, Hospital Clinico Universitario, Zaragoza, Spain
    Digestion 73:136-50. 2006
    ..The availability of poorly absorbed and effective antibiotics, like rifaximin, may represent an attractive alternative to prevent or limit NSAID-associated intestinal damage...
  30. doi The changing face of hospitalisation due to gastrointestinal bleeding and perforation
    A Lanas
    Hospital Clinico, Universidad de Zaragoza, Spain
    Aliment Pharmacol Ther 33:585-91. 2011
    ..Temporal changes in the incidence of cause-specific gastrointestinal (GI) complications may be one of the factors underlying changing medical practice patterns...
  31. ncbi Low-dose aspirin and upper gastrointestinal damage: epidemiology, prevention and treatment
    Angel Lanas
    Service of Gastroenterology, Instituto Aragones de Ciencias de la Salud, University Hospital, Zaragoza, Spain
    Curr Med Res Opin 23:163-73. 2007
    ..However, due to its action on cyclo-oxygenase (COX), aspirin is associated with upper gastrointestinal (GI) side effects including ulcers and bleeding...
  32. doi Gastrointestinal bleeding associated with low-dose aspirin use: relevance and management in clinical practice
    Angel Lanas
    Department of Gastroenterology, University Hospital, University of Zaragoza, Servicio de Aparato Digestivo, C Domingo Miral s n, 50009 Zaragoza, Zaragoza, Spain
    Expert Opin Drug Saf 10:45-54. 2011
    ..However, the reasons why some people develop serious lesions, whereas most only have minor, clinically irrelevant lesions are poorly understood...
  33. ncbi No allelic variant associations of the IL-1 and TNF gene polymorphisms in the susceptibility to duodenal ulcer disease
    M A Garcia-Gonzalez
    Unidad Mixta de Investigación and Department of Gastroenterology, Hospital Clinico Universitario Lozano Blesa, Zaragoza, Spain
    Int J Immunogenet 32:299-306. 2005
    ..Our data show no association between allelic variants of IL-1 and TNF gene polymorphisms in the susceptibility to and final outcome of duodenal ulcer...
  34. pmc Association of interleukin 1 gene family polymorphisms with duodenal ulcer disease
    M A Garcia-Gonzalez
    Instituto Aragonés de Ciencias de la Salud and Department of Gastroenterology, Hospital Clinico Universitario Lozano Blesa, Zaragoza, Spain
    Clin Exp Immunol 134:525-31. 2003
    ..Our results provide further evidence that host genetic factors play a key role in the pathogenesis of duodenal ulcer...
  35. ncbi Nitrovasodilators, low-dose aspirin, other nonsteroidal antiinflammatory drugs, and the risk of upper gastrointestinal bleeding
    A Lanas
    Service of Digestive Diseases, University Hospital, Zaragoza, Spain
    N Engl J Med 343:834-9. 2000
    ..In animals, these medications reduce the gastric damage induced by nonsteroidal antiinflammatory drugs. Nitric oxide, however, inhibits platelet aggregation and may contribute to bleeding from an ulcer...
  36. ncbi Low frequency of upper gastrointestinal complications in a cohort of high-risk patients taking low-dose aspirin or NSAIDS and omeprazole
    A Lanas
    Service of Digestive Diseases, University Hospital Lozano Blesa, Zaragoza, Spain
    Scand J Gastroenterol 38:693-700. 2003
    ..We studied the incidence of gastrointestinal complications in high-risk patients taking long-term low-dose aspirin or non-aspirin-NSAIDs combined with omeprazole in a real-life clinical setting...
  37. ncbi TGFB1 gene polymorphisms: their relevance in the susceptibility to Helicobacter pylori-related diseases
    M A Garcia-Gonzalez
    Unidad Mixta de Investigacion, Hospital Clinico Universitario Lozano Blesa, Zaragoza, Spain
    Genes Immun 7:640-6. 2006
    ..15-0.68; P=0.003). Our results show that the TGFB1 T+869C gene polymorphism is involved in the susceptibility to DU and provide further evidence that host genetic factors play a key role in the pathogenesis of H. pylori-related diseases...
  38. ncbi TNF and LTA gene polymorphisms reveal different risk in gastric and duodenal ulcer patients
    A Lanas
    Department of Gastroenterology, Hospital Clinico Universitario, Zaragoza, Spain
    Genes Immun 2:415-21. 2001
    ..pylori-infected patients (OR: 4.2; 95%CI: 1.7-10.2). These results suggest that TNF and LTA gene polymorphisms are related to the development of gastric and duodenal ulcer and may determine disease outcome in H. pylori infection...
  39. ncbi Risk of upper gastrointestinal bleeding in patients taking low-dose aspirin for the prevention of cardiovascular diseases
    P Serrano
    Service of Cardiology, Hospital Clinico Universitario Lozano Blesa, Zaragoza, Spain
    Aliment Pharmacol Ther 16:1945-53. 2002
    ..Most patients with vascular-occlusive diseases benefit from low-dose aspirin (75-325 mg/day). However, they have an increased risk of upper gastrointestinal bleeding (UGIB)...
  40. ncbi Clinical trends in ulcer diagnosis in a population with high prevalence of Helicobacter pylori infection
    M A Perez-Aisa
    Service of Digestive Diseases, University Hospital, Zaragoza, Spain
    Aliment Pharmacol Ther 21:65-72. 2005
    ..It is unknown whether the incidence of peptic ulcer changes in areas with a high prevalence of Helicobacter pylori infection...
  41. ncbi Characterization of the prostaglandin E2 pathway in a rat model of esophageal adenocarcinoma
    E Piazuelo
    IIS Aragón, Aragon Institute of Health Scineces, Zaragoza, Spain
    Curr Cancer Drug Targets 12:132-43. 2012
    ..Esophagojejunostomy with gastric preservation was performed in wistar rats to induce gastroduodenal reflux. Rats were sacrificed 2 or 4 months after surgery. Nine non-operated rats were used to obtain normal (control) esophageal tissues...
  42. ncbi The appropriate use of proton-pump inhibitor co-therapy with non-steroidal anti-inflammatory drugs and cyclo-oxygenase-2 selective inhibitors
    A Lanas
    University of Zaragoza, Zaragosa, Spain
    Aliment Pharmacol Ther 21:2-4, 21-4. 2005
  43. doi Risk factors for advanced lesions undetected at prior colonoscopy: not always poor preparation
    A Ferrandez
    Service of Digestives Diseases, Hospital Clinico Lozano Blesa, CIBERehd, Zaragoza, Spain
    Endoscopy 42:1071-6. 2010
    ..However, adenoma miss rates in tandem colonoscopy studies vary from 2 % to 26 %. We aimed to investigate the rates of advanced neoplasia in patients with a prior normal colonoscopy in an outpatient endoscopy unit...
  44. ncbi Prostaglandin EP2 receptor expression is increased in Barrett's oesophagus and oesophageal adenocarcinoma
    P Jimenez
    CIBER Enfermedades Hepáticas y Digestivas CIBERehd, University Hospital, Zaragoza, Spain
    Aliment Pharmacol Ther 31:440-51. 2010
    ..Accumulating evidence suggests that cyclooxygenase-2 (COX-2)-derived prostaglandin E2 (PGE2) is involved in oesophageal adenocarcinogenesis. PGE2 exerts its biological action by binding to specific receptors (EP1, EP2, EP3 and EP4)...
  45. ncbi Cyclo-oxygenase-1/cyclo-oxygenase-2 non selective non-steroidal anti-inflammatory drugs: epidemiology of gastrointestinal events
    A Lanas
    Gastroenterology Unit, University Hospital Lozano Blesa, Zaragoza, Spain
    Dig Liver Dis 33:S29-34. 2001
    ..Epidemiological studies have also shown that nitric oxide donors and antisecretory drugs reduce the risk of upper gastrointestinal bleeding both in non-steroidal anti-inflammatory drug and low-dose aspirin users...
  46. ncbi Gastric cancer susceptibility is not linked to pro-and anti-inflammatory cytokine gene polymorphisms in whites: a Nationwide Multicenter Study in Spain
    María Asunción García-Gonzalez
    Instituto Aragones de Ciencias de la Salud, Zaragoza, Spain
    Am J Gastroenterol 102:1878-92. 2007
    ..Our goal was to evaluate the influence of Helicobacter pylori (H. pylori) infection and host genetic factors on GC susceptibility in a population of Spanish white GC patients...
  47. doi [Risk of gastrointestinal bleeding with aspirin and platelet antiaggregants]
    Gianfranco Nardulli
    Instituto Aragones de Ciencias de la Salud, Servicio de Aparato Digestivo, Hospital Clinico Universitario Lozano Blesa, Zaragoza, Espana
    Gastroenterol Hepatol 32:36-43. 2009
    ..The use of proton pump inhibitors and/or H. pylori eradication should allow a positive balance, even in patients with gastrointestinal risk factors...
  48. ncbi Helicobacter pylori increases the risk of upper gastrointestinal bleeding in patients taking low-dose aspirin
    A Lanas
    Service of Gastroenterology, University Hospital Lozano Blesa, Zaragoza, Spain
    Aliment Pharmacol Ther 16:779-86. 2002
    ..To evaluate the role of Helicobacter pylori infection and other clinical factors in the risk of upper gastrointestinal bleeding in patients taking low-dose aspirin...
  49. ncbi Drug-related damage of the ageing gastrointestinal tract
    Carlos Sostres
    Service of Digestive Diseases, University Hospital, Instituto Aragones de Ciencias de la Salud, CIBERehd, University of Zaragoza, Spain
    Best Pract Res Clin Gastroenterol 23:849-60. 2009
    ..Treatment of Helicobacter pylori infection is beneficial in patients starting therapy with these agents, especially in the presence of ulcer history. The best strategy to prevent lower GI complications has yet to be defined...
  50. doi [Analysis of differences between indication and prescription of gastroprotection in patients with risk factors treated with nonsteroidal anti-inflammatory agents: the GAP study]
    Angel Lanas
    Servicio de Aparato Digestivo, Hospital Clinico Lozano Blesa, CIBERehd, Instituto Aragones de Ciencias de la Salud, Universidad de Zaragoza, Zaragoza, Espana
    Gastroenterol Hepatol 33:80-91. 2010
    ....
  51. ncbi Collagen secretion by human gastric and skin fibroblasts: implications for ulcer healing
    A Lanas
    Unidad Mixta de Investigacion, Hospital Clinico Universitario, Universidad de Zaragoza, Espana
    Eur Surg Res 30:48-54. 1998
    ..These data provide new insights into the wound-healing process...
  52. ncbi Prevention of aspirin-induced gastroduodenal damage: H. pylori infection eradication versus proton pump inhibitors or both
    A Lanas
    Service of Gastroenterology, Clinic University Hospital, Saragossa, Spain
    Dig Liver Dis 36:655-7. 2004
  53. ncbi Non-steroidal anti-inflammatory drugs and gastrointestinal bleeding
    A Lanas
    Service of Gastroenterology, University Hospital, Zaragoza, Spain
    Ital J Gastroenterol Hepatol 31:S37-42. 1999
    ....
  54. ncbi A nationwide study of mortality associated with hospital admission due to severe gastrointestinal events and those associated with nonsteroidal antiinflammatory drug use
    Angel Lanas
    Servicio de Aparato Digestivo, Hospital Clinico Zaragoza, Zaragoza, Spain
    Am J Gastroenterol 100:1685-93. 2005
    ..The worst outcome of gastrointestinal complications is death. Data regarding those associated with nonsteroidal antiinflammatory drug (NSAID) or aspirin use are scarce...
  55. doi Adverse effects of non-steroidal anti-inflammatory drugs (NSAIDs, aspirin and coxibs) on upper gastrointestinal tract
    Carlos Sostres
    Service of Digestive Diseases, University Hospital Lozano Blesa, Zaragoza, Spain
    Best Pract Res Clin Gastroenterol 24:121-32. 2010
    ..The probable introduction of NO-NSAIDs in the market in the near future may open a new therapeutic option for patients with hypertension who need NSAIDs...
  56. pmc Effect of oral anticoagulants on the outcome of faecal immunochemical test
    L Bujanda
    Department of Gastroenterology, Hospital Universitario Donostia, Instituto Biodonostia, Centro de Investigación Biomédica en Red en Enfermedades Hepáticas y Digestivas CIBEREHD, Universidad del Pais Vasco UPV EHU, San Sebastian, Spain
    Br J Cancer 110:1334-7. 2014
    ..We aimed to evaluate whether oral anticoagulants (OACs) alter faecal immunochemical test (FIT) performance in average-risk colorectal cancer (CRC) screening...
  57. ncbi Underutilization of gastroprotection for at-risk patients undergoing percutaneous coronary intervention: Spain compared with the United States
    R Casado-Arroyo
    University Hospital Lozano Blesa, Zaragoza, Spain
    Aliment Pharmacol Ther 32:689-95. 2010
    ..Proton pump inhibitors (PPIs) are the preferred agents for the prevention of aspirin-associated upper gastrointestinal bleeding (UGIB). Data are limited to determine whether PPIs are being used to reduce UGIB risk...
  58. ncbi [Antisecretory drugs and prophylaxis of secondary gastrointestinal effects associated with the consumption of non steroid anti-inflammatory drugs]
    A Lanas
    Servicio de Aparato Digestivo, Hospital Clinico Universitario, Zaragoza
    Med Clin (Barc) 114:57-62. 2000
    ..To evaluate the available evidence on the efficacy of antisecretory drugs in the prevention of serious upper gastrointestinal adverse events associated with the use of nonsteroidal antiinflammatory drugs (NSAID)...
  59. ncbi [Cost stratification of nonsteroidal anti-inflammatory drug-associated gastrointestinal side effects]
    A Lanas
    Servicio de Aparato Digestivo, Hospital Clinico Universitario, Zaragoza
    Med Clin (Barc) 114:46-53. 2000
    ..Nonsteroidal anti-inflammatory drugs induce gastrointestinal side effects. In this study we have analyzed the economic impact of these side effects on the National Health System...
  60. ncbi Toxicity of NSAIDs in the stomach and duodenum
    A Lanas
    Service of Gastroenterology, University Hospital, Zaragoza, Spain
    Eur J Gastroenterol Hepatol 11:375-81. 1999
    ..At present, the role of Helicobacter pylori in NSAID-induced gastroduodenal lesions is controversial and there is no agreement in considering the organism as a risk factor and indicating its eradication in NSAID users...
  61. ncbi Effect of exogenous administration of transforming growth factor-beta and famotidine on the healing of duodenal ulcer under the impact of indomethacin
    A Pérez-Aisa
    Service of Digestive Diseases, University Hospital, C San Juan Bosco 15, 50009 Zaragoza, Spain
    Dig Liver Dis 35:397-403. 2003
    ..Non-steroidal anti-inflammatory drugs delay ulcer healing and cause refractory peptic ulcers in humans...
  62. ncbi Treatment and prevention of aspirin-induced gastroduodenal ulcers and gastrointestinal bleeding
    Angel Lanas
    Service of Gastroenterology, University Hospital Lozano Blesa, Zaragoza, Spain
    Expert Opin Drug Saf 1:245-52. 2002
    ..The role of Helicobacter pylori is controversial in NSAID users, but there is now wide agreement that H. pylori infection increases mucosal damage and the risk of upper GI bleeding in low-dose aspirin users...
  63. ncbi Trends in Barrett's esophagus diagnosis in Southern Europe: implications for surveillance
    Javier Alcedo
    Service of Digestive Diseases, Clínico Lozano Blesa Hospital, Institute of Health Sciences, CIBERehd, University of Zaragoza, Zaragoza, Spain
    Dis Esophagus 22:239-48. 2009
    ..Progression to low-grade dysplasia and adenocarcinoma is rare. Surveillance may have a low impact on the survival of adenocarcinoma patients in Southern Europe...
  64. ncbi Effect of antisecretory drugs and nitrates on the risk of ulcer bleeding associated with nonsteroidal anti-inflammatory drugs, antiplatelet agents, and anticoagulants
    Angel Lanas
    Servicio de Aparato Digestivo, Hospital Clinico Zaragoza, CIBER HEPAD, Zaragoza, Spain
    Am J Gastroenterol 102:507-15. 2007
    ..Here, we report the effect of antisecretory drugs and nitrates on the risk of upper GI peptic ulcer bleeding (UGIB) associated with nonselective NSAIDs, aspirin, antiplatelet agents, and anticoagulants...
  65. ncbi Susceptibility genetic variants associated with colorectal cancer risk correlate with cancer phenotype
    Anna Abuli
    Department of Gastroenterology, Hospital del Mar, Institut Municipal d Investigacio Medica, Pompeu Fabra University, Barcelona, Catalonia, Spain
    Gastroenterology 139:788-96, 796.e1-6. 2010
    ..Characterization of such a correlation would improve CRC management and prevention programs. We assessed the association between these genetic variants and CRC phenotype in patients and modeled pairwise combinations to detect epistasis...
  66. pmc The polymorphic IL-1B and IL-1RN genes in the aetiopathogenesis of peptic ulcer
    M A Garcia-Gonzalez
    Hospital Clínico Universitario and Unidad Mixta de Investigación, Zaragoza, Spain
    Clin Exp Immunol 125:368-75. 2001
    ..37, 95% CI = 0.14-0.9). Our data suggest that IL-1B and IL-1RN genes in addition to bacterial and environmental factors play a key role in determining the final outcome of peptic ulcer disease...
  67. ncbi Gastroesophageal reflux disease (GERD): current agents and future perspective
    A Lanas
    Service of Gastroenterology, University Hospital, Zaragoza, Spain
    Curr Pharm Des 7:1-18. 2001
    ..Finally, the modulation of some growth factors might have a potential role in delayed esophageal ulcer healing, refractory esophagitis and in Barrett's esophagus...
  68. doi Risk factors associated with a decrease ≥2 g/dL in haemoglobin and/or ≥10% haematocrit in osteoarthritis patients taking celecoxib or a nonselective NSAID plus a PPI in a large randomised controlled trial (CONDOR)
    A Lanas
    CIBERehd IIS Aragón, Universidad de Zaragoza, Zaragoza, Spain
    Aliment Pharmacol Ther 36:485-92. 2012
    ..This adverse event is potentially clinically relevant in long-term NSAID treatment...
  69. ncbi Superoxide anion and nitric oxide in high-grade esophagitis induced by acid and pepsin in rabbits
    A Lanas
    Service of Gastroenterology, University Hospital and University of Zaragoza, Spain
    Dig Dis Sci 46:2733-43. 2001
    ..Superoxide dismutase but not NO-donor-modifying agents might have a therapeutic role in preventing severe esophageal mucosal damage induced by acid and pepsin...
  70. ncbi COX-2 inhibition in esophagitis, Barrett's esophagus and esophageal cancer
    E Piazuelo
    Instituto Aragones de Ciencias de la Salud, Hospital Clinico Universitario, Zafagoza, Spain
    Curr Pharm Des 9:2267-80. 2003
    ..Further studies are necessary in order to better understand factors involved in COX-2 up-regulation and mechanisms of COX-2 associated tumorigenesis in the esophagus...
  71. doi Clinical predictors of poor outcomes among patients with nonvariceal upper gastrointestinal bleeding in Europe
    A Lanas
    Gastroenterology, University of Zaragoza, Servicio de Aparato Digestivo, Hospital Clinico Universitario Lozano Blesa, C Domingo Miral s n, Zaragoza, Spain
    Aliment Pharmacol Ther 33:1225-33. 2011
    ..Despite advances in endoscopic and pharmacological treatment during the past two decades, the incidence of mortality associated with NVUGIB has remained relatively constant...
  72. ncbi Nonsteroidal anti-inflammatory drugs, low-dose aspirin, and potential ways of reducing the risk of complications
    A Lanas
    Service of Gastroenterology, University Hospital, Zaragoza, Spain
    Eur J Gastroenterol Hepatol 13:623-6. 2001
    ..Epidemiological studies have also shown that nitric oxide donor drugs reduce the risk of upper GI bleeding, which might be important in patients receiving low-dose aspirin...
  73. ncbi Experimental esophagitis induced by acid and pepsin in rabbits mimicking human reflux esophagitis
    A Lanas
    Services of Gastroenterology, Research Unit Unidad Mixta de Investigación, University Hospital and University of Zaragoza, Spain
    Gastroenterology 116:97-107. 1999
    ..The aim of this study was to develop a model of esophagitis in rabbits mimicking human reflux esophagitis...
  74. ncbi [Defense of the esophageal mucosa as a therapeutic target in gastroesophageal reflux disease]
    E Piazuelo
    Instituto Aragones de Ciencias de la Salud, Zaragoza, Espana
    Gastroenterol Hepatol 27:274-84. 2004
  75. ncbi Risk of upper gastrointestinal bleeding associated with non-aspirin cardiovascular drugs, analgesics and nonsteroidal anti-inflammatory drugs
    Angel Lanas
    Service of Gastroenterology, University Hospital Lozano Blesa, C San Juan Bosco 15, 50009 Zaragoza, Spain
    Eur J Gastroenterol Hepatol 15:173-8. 2003
    ..To evaluate the risk of upper gastrointestinal bleeding associated with non-aspirin cardiovascular drug therapy, common analgesics and individual nonsteroidal anti-inflammatory drugs (NSAIDs)...
  76. ncbi Bleeding duodenal ulcer and association with polymorphism of endothelial constitutive nitric oxide synthase gene
    Trinidad Serrano
    Service of Gastroenterology, Research Unit, University Hospital, Zaragoza, Spain
    Dig Dis Sci 47:996-1000. 2002
    ..49; 95% CI = 0.25-0.95; P = 0.03). In conclusion, this ecNOS4 polymorphism gene could be related to susceptibility of duodenal ulcer patients to bleeding...
  77. ncbi Superoxide dismutase prevents development of adenocarcinoma in a rat model of Barrett's esophagus
    Elena Piazuelo
    Instituto Aragones de Ciencias de la Salud, Unidad Mixta de Investigacion, Zaragoza, Spain
    World J Gastroenterol 11:7436-43. 2005
    ..To test whether antioxidant treatment could prevent the progression of Barrett's esophagus to adenocarcinoma...
  78. ncbi Free radicals and antioxidant systems in reflux esophagitis and Barrett's esophagus
    Pilar Jimenez
    Aragonés Institute of Health Sciences, and Gastroenterology Service, Lozano Blesa University Hospital Clinic, Avenida San Juan Bosco, C Domingo Miral, s n 15 50009 Zaragoza, Spain
    World J Gastroenterol 11:2697-703. 2005
    ..Experimental studies suggest that free radicals are involved in acid and pepsin-induced damage of esophageal mucosa. The profile and balance between free radicals and antioxidant systems in human esophagitis are unknown...
  79. ncbi Effects of selective PGE2 receptor antagonists in esophageal adenocarcinoma cells derived from Barrett's esophagus
    Elena Piazuelo
    Instituto Aragones de Ciencias de la Salud, Zaragoza, Spain
    Prostaglandins Other Lipid Mediat 81:150-61. 2006
    ..These findings suggest a potential role for EP selective antagonists in the treatment of esophageal adenocarcinoma...
  80. ncbi Peptic ulcer and bleeding events associated with rofecoxib in a 3-year colorectal adenoma chemoprevention trial
    Angel Lanas
    Department of Medicine, University Clinic Hospital, Instituto Aragones de Ciencias de la Salud CIBER HEPAD Zaragoza, Spain
    Gastroenterology 132:490-7. 2007
    ....
  81. ncbi Lack of association of IL-12 p40 gene polymorphism with peptic ulcer disease
    María A García-González
    Instituto Aragonés de Ciencias de la Salud and Department of Gastroenterology, Hospital Clinico Universitario Lozano Blesa, Zaragoza, Spain
    Hum Immunol 66:72-6. 2005
    ..Our data reveal that the IL12B 1188 (A-->C) gene polymorphism is not involved in defining the genetic basis of the susceptibility to and final outcome of peptic ulcer disease...
  82. ncbi The prevalence of peptic ulcer not related to Helicobacter pylori or non-steroidal anti-inflammatory drug use is negligible in southern Europe
    M Teresa Arroyo
    Service of Gastroenterology, Hospital Clinico, Zaragoza, Spain
    Helicobacter 9:249-54. 2004
    ..We investigated the frequency of H. pylori-negative peptic ulcer without intake of nonsteroidal anti-inflammatory drugs (NSAIDs) in a Mediterranean European country...
  83. doi A case-control study of the association between polymorphisms of the endothelial nitric oxide synthase and glycoprotein IIIa genes and upper gastrointestinal bleeding in users of low-dose aspirin
    Elena Piazuelo
    Instituto Aragones de Ciencias de la Salud, Zaragoza, Spain
    Clin Ther 30:121-30. 2008
    ..Previous studies have reported a potential genetic predisposition to NSAID-related upper gastrointestinal (GI) bleeding...
  84. ncbi Relevance of IL-1 and TNF gene polymorphisms on interleukin-1beta and tumor necrosis factor-alpha gastric mucosal production
    María A García-González
    Instituto Aragones de Ciencias de la Salud, Zaragoza, Spain
    Hum Immunol 70:935-45. 2009
    ..Our results indicate that the VNTR polymorphism of the IL1RN gene influences IL-1beta gastric mucosal production in patients infected with H. pylori...
  85. ncbi NSAIDs-induced gastrointestinal damage. Review
    M Arroyo
    Service of Gastroenterology, University Hospital of Zaragoza, Zaragoza, Spain
    Minerva Gastroenterol Dietol 52:249-59. 2006
    ....
  86. pmc A two-phase case-control study for colorectal cancer genetic susceptibility: candidate genes from chromosomal regions 9q22 and 3q22
    A Abuli
    Department of Gastroenterology, Hospital Clinic, CIBERehd, IDIBAPS, University of Barcelona, Villarroel 170, 08036, Barcelona, Catalonia, Spain
    Br J Cancer 105:870-5. 2011
    ..There are several plausible candidate genes for CRC susceptibility within the aforementioned linkage regions including PTCH1, XPA and TGFBR1 in 9q22-31, and EPHB1 and MRAS in 3q21-q24...
  87. ncbi [Update on gastrointestinal disorders associated with non-steroidal anti-inflammatory drugs]
    Angel Lanas
    Servicio de Aparato Digestivo, Hospital Clinico Universitario Lozano Blesa, CIBERehd, IACS, Universidad de Zaragoza, Zaragoza, Espana
    Gastroenterol Hepatol 31:35-41. 2008
    ..g., NSAID+proton pump inhibitor). One study showed that this combination was associated with fewer gastroduodenal lesions and could avoid the need to prescribe a gastroprotective agent and poor compliance...
  88. pmc Role of nitric oxide in the gastrointestinal tract
    Angel Lanas
    Servicio de Aparato Digestivo, Hospital Clinico Zaragoza, CIBERehd, IACS, Universidad de Zaragoza, C Domingo Miral s n, 50009 Zaragoza, Spain
    Arthritis Res Ther 10:S4. 2008
    ..Therefore, these agents provide a potential therapeutic option for patients with arthritis who require long-term NSAID therapy...
  89. ncbi Prevention of anti-inflammatory drug-induced gastrointestinal damage: benefits and risks of therapeutic strategies
    Angel Lanas
    Instituto Aragones de Ciencias de la Salud, Service of Gastroenterology, University Hospital, Zaragoza, Spain
    Ann Med 38:415-28. 2006
    ..A PPI+coxib is indicated in those at highest risk (e.g. previous ulcer bleeding). PPI therapy must be considered for the treatment and prevention of NSAID-induced dyspepsia...
  90. pmc Colorectal cancer prognosis twenty years later
    Luis Bujanda
    Departament of Gastroenterology, CIBERehd, University of Country Basque, Donostia Hospital, Avda Sancho El Sabio, 17 2D, 20010 San Sebastian, Spain
    World J Gastroenterol 16:862-7. 2010
    ..To evaluate changes in colorectal cancer (CRC) survival over the last 20 years...
  91. ncbi Diaphragm disease of the small bowel: a case without apparent nonsteroidal antiinflammatory drug use
    S Santolaria
    Service of Gastroenterology, University Hospital Lozano Blesa, Zaragoza, Spain
    J Clin Gastroenterol 32:344-6. 2001
    ..CONCLUSIONS: We suggest that diaphragm-like strictures might be developed as a nonspecific response to different damaging insults to the intestine and are not necessarily associated with NSAID use...
  92. pmc Helicobacter pylori stimulates pepsinogen secretion from isolated human peptic cells
    S Lorente
    Service of Gastroenterology, University Hospital, Zaragoza, Spain
    Gut 50:13-8. 2002
    ..Patients with H pylori associated gastritis or duodenal ulcer have increased serum pepsinogen levels which decrease after eradication. The mechanisms of H pylori induced gastric mucosal damage are not completely understood...
  93. ncbi Selective COX-2 inhibition is associated with decreased mucosal damage induced by acid and pepsin in rabbit esophagitis
    Angel Lanas
    Service of Digestive Diseases, Unit of Gastrointestinal Research, University Hospital, Unidad Mixta de Investigacion, Zaragoza, Spain
    Inflammation 27:21-9. 2003
    ..To evaluate the effects of COX-1 and/or COX-2 inhibition in a model of chronic esophagitis in rabbits...
  94. doi Discovery of specific flavodoxin inhibitors as potential therapeutic agents against Helicobacter pylori infection
    Nunilo Cremades
    Departamento de Bioquimica y Biologia Molecular y Celular, Facultad de Ciencias, Universidad de Zaragoza, Spain
    ACS Chem Biol 4:928-38. 2009
    ..These newly discovered inhibitors represent promising selective leads against the different diseases associated to H. pylori infection...
  95. pmc Aberrant gene promoter methylation associated with sporadic multiple colorectal cancer
    Victoria Gonzalo
    Department of Gastroenterology, Hospital Clinic, Centro de Investigación Biomédica en Red en el Area temática de Enfermedades Hepáticas y Digestivas, Institut d Investigacions Biomediques August Pi i Sunyer, University of Barcelona, Barcelona, Catalonia, Spain
    PLoS ONE 5:e8777. 2010
    ....
  96. ncbi Consensus development conference on the use of nonsteroidal anti-inflammatory agents, including cyclooxygenase-2 enzyme inhibitors and aspirin
    C Mel Wilcox
    Department of Internal Medicine, University of Alabama at Birmingham, Birmingham, Alabama, USA
    Clin Gastroenterol Hepatol 4:1082-9. 2006
  97. ncbi Celecoxib versus diclofenac and omeprazole to prevent recurrent ulcer bleeding
    Angel Lanas
    N Engl J Med 348:2464-6; author reply 2464-6. 2003
  98. ncbi Association of Helicobacter pylori-related distal gastric cancer with the HLA class II gene DQB10602 and cagA strains in a southern European population
    Enrique Quintero
    Gastroenterology Department, University Hospital of the Canary Islands, Spain
    Helicobacter 10:12-21. 2005
    ..In the present study we evaluated the influence of host HLA DQA1 and DQB1 loci, H. pylori genotype, and socio-economic factors on predicting H. pylori-associated distal gastric cancer in a southern European population...
  99. ncbi Improving on our goal to reduce NSAID-induced GI complications: a challenging task?
    Angel Lanas
    Am J Gastroenterol 103:1104-5. 2008
    ..In order to more effectively pursue this goal, we will need to develop new and more complex approaches...
  100. ncbi Atypical and aggressive upper gastrointestinal ulceration associated with aspirin abuse
    Basil I Hirschowitz
    Division of Gastroenterology and Hepatology, University of Alabama at Birmingham, UAB Station, Birmingham, AL 35294 0007, USA
    J Clin Gastroenterol 34:523-8. 2002
    ..Although some ulcers were caused by Zollinger-Ellison syndrome (ZES), an atypical clinical course in other patients, especially with those with multiple ulcers, suggested abuse of aspirin...