A Lanas

Summary

Affiliation: University of Zaragoza
Country: Spain

Publications

  1. ncbi request reprint Collagen secretion by human gastric and skin fibroblasts: implications for ulcer healing
    A Lanas
    Unidad Mixta de Investigacion, Hospital Clinico Universitario, Universidad de Zaragoza, Espana
    Eur Surg Res 30:48-54. 1998
  2. ncbi request reprint Prevention of aspirin-induced gastroduodenal damage: H. pylori infection eradication versus proton pump inhibitors or both
    A Lanas
    Service of Gastroenterology, Clinic University Hospital, Saragossa, Spain
    Dig Liver Dis 36:655-7. 2004
  3. ncbi request reprint Low frequency of upper gastrointestinal complications in a cohort of high-risk patients taking low-dose aspirin or NSAIDS and omeprazole
    A Lanas
    Service of Digestive Diseases, University Hospital Lozano Blesa, Zaragoza, Spain
    Scand J Gastroenterol 38:693-700. 2003
  4. ncbi request reprint Effect of exogenous administration of transforming growth factor-beta and famotidine on the healing of duodenal ulcer under the impact of indomethacin
    A Pérez-Aisa
    Service of Digestive Diseases, University Hospital, C San Juan Bosco 15, 50009 Zaragoza, Spain
    Dig Liver Dis 35:397-403. 2003
  5. ncbi request reprint Risk of upper gastrointestinal bleeding associated with non-aspirin cardiovascular drugs, analgesics and nonsteroidal anti-inflammatory drugs
    Angel Lanas
    Service of Gastroenterology, University Hospital Lozano Blesa, C San Juan Bosco 15, 50009 Zaragoza, Spain
    Eur J Gastroenterol Hepatol 15:173-8. 2003
  6. ncbi request reprint Helicobacter pylori increases the risk of upper gastrointestinal bleeding in patients taking low-dose aspirin
    A Lanas
    Service of Gastroenterology, University Hospital Lozano Blesa, Zaragoza, Spain
    Aliment Pharmacol Ther 16:779-86. 2002
  7. ncbi request reprint Peptic ulcer and bleeding events associated with rofecoxib in a 3-year colorectal adenoma chemoprevention trial
    Angel Lanas
    Department of Medicine, University Clinic Hospital, Instituto Aragones de Ciencias de la Salud CIBER HEPAD Zaragoza, Spain
    Gastroenterology 132:490-7. 2007
  8. ncbi request reprint Cyclo-oxygenase-1/cyclo-oxygenase-2 non selective non-steroidal anti-inflammatory drugs: epidemiology of gastrointestinal events
    A Lanas
    Gastroenterology Unit, University Hospital Lozano Blesa, Zaragoza, Spain
    Dig Liver Dis 33:S29-34. 2001
  9. ncbi request reprint [Antisecretory drugs and prophylaxis of secondary gastrointestinal effects associated with the consumption of non steroid anti-inflammatory drugs]
    A Lanas
    Servicio de Aparato Digestivo, Hospital Clinico Universitario, Zaragoza
    Med Clin (Barc) 114:57-62. 2000
  10. ncbi request reprint Non-steroidal anti-inflammatory drugs and gastrointestinal bleeding
    A Lanas
    Service of Gastroenterology, University Hospital, Zaragoza, Spain
    Ital J Gastroenterol Hepatol 31:S37-42. 1999

Collaborators

Detail Information

Publications74

  1. ncbi request reprint Collagen secretion by human gastric and skin fibroblasts: implications for ulcer healing
    A Lanas
    Unidad Mixta de Investigacion, Hospital Clinico Universitario, Universidad de Zaragoza, Espana
    Eur Surg Res 30:48-54. 1998
    ..These data provide new insights into the wound-healing process...
  2. ncbi request reprint Prevention of aspirin-induced gastroduodenal damage: H. pylori infection eradication versus proton pump inhibitors or both
    A Lanas
    Service of Gastroenterology, Clinic University Hospital, Saragossa, Spain
    Dig Liver Dis 36:655-7. 2004
  3. ncbi request reprint Low frequency of upper gastrointestinal complications in a cohort of high-risk patients taking low-dose aspirin or NSAIDS and omeprazole
    A Lanas
    Service of Digestive Diseases, University Hospital Lozano Blesa, Zaragoza, Spain
    Scand J Gastroenterol 38:693-700. 2003
    ..We studied the incidence of gastrointestinal complications in high-risk patients taking long-term low-dose aspirin or non-aspirin-NSAIDs combined with omeprazole in a real-life clinical setting...
  4. ncbi request reprint Effect of exogenous administration of transforming growth factor-beta and famotidine on the healing of duodenal ulcer under the impact of indomethacin
    A Pérez-Aisa
    Service of Digestive Diseases, University Hospital, C San Juan Bosco 15, 50009 Zaragoza, Spain
    Dig Liver Dis 35:397-403. 2003
    ..Non-steroidal anti-inflammatory drugs delay ulcer healing and cause refractory peptic ulcers in humans...
  5. ncbi request reprint Risk of upper gastrointestinal bleeding associated with non-aspirin cardiovascular drugs, analgesics and nonsteroidal anti-inflammatory drugs
    Angel Lanas
    Service of Gastroenterology, University Hospital Lozano Blesa, C San Juan Bosco 15, 50009 Zaragoza, Spain
    Eur J Gastroenterol Hepatol 15:173-8. 2003
    ..To evaluate the risk of upper gastrointestinal bleeding associated with non-aspirin cardiovascular drug therapy, common analgesics and individual nonsteroidal anti-inflammatory drugs (NSAIDs)...
  6. ncbi request reprint Helicobacter pylori increases the risk of upper gastrointestinal bleeding in patients taking low-dose aspirin
    A Lanas
    Service of Gastroenterology, University Hospital Lozano Blesa, Zaragoza, Spain
    Aliment Pharmacol Ther 16:779-86. 2002
    ..To evaluate the role of Helicobacter pylori infection and other clinical factors in the risk of upper gastrointestinal bleeding in patients taking low-dose aspirin...
  7. ncbi request reprint Peptic ulcer and bleeding events associated with rofecoxib in a 3-year colorectal adenoma chemoprevention trial
    Angel Lanas
    Department of Medicine, University Clinic Hospital, Instituto Aragones de Ciencias de la Salud CIBER HEPAD Zaragoza, Spain
    Gastroenterology 132:490-7. 2007
    ....
  8. ncbi request reprint Cyclo-oxygenase-1/cyclo-oxygenase-2 non selective non-steroidal anti-inflammatory drugs: epidemiology of gastrointestinal events
    A Lanas
    Gastroenterology Unit, University Hospital Lozano Blesa, Zaragoza, Spain
    Dig Liver Dis 33:S29-34. 2001
    ..Epidemiological studies have also shown that nitric oxide donors and antisecretory drugs reduce the risk of upper gastrointestinal bleeding both in non-steroidal anti-inflammatory drug and low-dose aspirin users...
  9. ncbi request reprint [Antisecretory drugs and prophylaxis of secondary gastrointestinal effects associated with the consumption of non steroid anti-inflammatory drugs]
    A Lanas
    Servicio de Aparato Digestivo, Hospital Clinico Universitario, Zaragoza
    Med Clin (Barc) 114:57-62. 2000
    ..To evaluate the available evidence on the efficacy of antisecretory drugs in the prevention of serious upper gastrointestinal adverse events associated with the use of nonsteroidal antiinflammatory drugs (NSAID)...
  10. ncbi request reprint Non-steroidal anti-inflammatory drugs and gastrointestinal bleeding
    A Lanas
    Service of Gastroenterology, University Hospital, Zaragoza, Spain
    Ital J Gastroenterol Hepatol 31:S37-42. 1999
    ....
  11. ncbi request reprint Experimental esophagitis induced by acid and pepsin in rabbits mimicking human reflux esophagitis
    A Lanas
    Services of Gastroenterology, Research Unit Unidad Mixta de Investigación, University Hospital and University of Zaragoza, Spain
    Gastroenterology 116:97-107. 1999
    ..The aim of this study was to develop a model of esophagitis in rabbits mimicking human reflux esophagitis...
  12. ncbi request reprint Toxicity of NSAIDs in the stomach and duodenum
    A Lanas
    Service of Gastroenterology, University Hospital, Zaragoza, Spain
    Eur J Gastroenterol Hepatol 11:375-81. 1999
    ..At present, the role of Helicobacter pylori in NSAID-induced gastroduodenal lesions is controversial and there is no agreement in considering the organism as a risk factor and indicating its eradication in NSAID users...
  13. ncbi request reprint [Cost stratification of nonsteroidal anti-inflammatory drug-associated gastrointestinal side effects]
    A Lanas
    Servicio de Aparato Digestivo, Hospital Clinico Universitario, Zaragoza
    Med Clin (Barc) 114:46-53. 2000
    ..Nonsteroidal anti-inflammatory drugs induce gastrointestinal side effects. In this study we have analyzed the economic impact of these side effects on the National Health System...
  14. ncbi request reprint Gastroesophageal reflux disease (GERD): current agents and future perspective
    A Lanas
    Service of Gastroenterology, University Hospital, Zaragoza, Spain
    Curr Pharm Des 7:1-18. 2001
    ..Finally, the modulation of some growth factors might have a potential role in delayed esophageal ulcer healing, refractory esophagitis and in Barrett's esophagus...
  15. ncbi request reprint Nitrovasodilators, low-dose aspirin, other nonsteroidal antiinflammatory drugs, and the risk of upper gastrointestinal bleeding
    A Lanas
    Service of Digestive Diseases, University Hospital, Zaragoza, Spain
    N Engl J Med 343:834-9. 2000
    ..In animals, these medications reduce the gastric damage induced by nonsteroidal antiinflammatory drugs. Nitric oxide, however, inhibits platelet aggregation and may contribute to bleeding from an ulcer...
  16. ncbi request reprint No allelic variant associations of the IL-1 and TNF gene polymorphisms in the susceptibility to duodenal ulcer disease
    M A Garcia-Gonzalez
    Unidad Mixta de Investigación and Department of Gastroenterology, Hospital Clinico Universitario Lozano Blesa, Zaragoza, Spain
    Int J Immunogenet 32:299-306. 2005
    ..Our data show no association between allelic variants of IL-1 and TNF gene polymorphisms in the susceptibility to and final outcome of duodenal ulcer...
  17. pmc Association of interleukin 1 gene family polymorphisms with duodenal ulcer disease
    M A Garcia-Gonzalez
    Instituto Aragonés de Ciencias de la Salud and Department of Gastroenterology, Hospital Clinico Universitario Lozano Blesa, Zaragoza, Spain
    Clin Exp Immunol 134:525-31. 2003
    ..Our results provide further evidence that host genetic factors play a key role in the pathogenesis of duodenal ulcer...
  18. ncbi request reprint TGFB1 gene polymorphisms: their relevance in the susceptibility to Helicobacter pylori-related diseases
    M A Garcia-Gonzalez
    Unidad Mixta de Investigacion, Hospital Clinico Universitario Lozano Blesa, Zaragoza, Spain
    Genes Immun 7:640-6. 2006
    ..15-0.68; P=0.003). Our results show that the TGFB1 T+869C gene polymorphism is involved in the susceptibility to DU and provide further evidence that host genetic factors play a key role in the pathogenesis of H. pylori-related diseases...
  19. ncbi request reprint TNF and LTA gene polymorphisms reveal different risk in gastric and duodenal ulcer patients
    A Lanas
    Department of Gastroenterology, Hospital Clinico Universitario, Zaragoza, Spain
    Genes Immun 2:415-21. 2001
    ..pylori-infected patients (OR: 4.2; 95%CI: 1.7-10.2). These results suggest that TNF and LTA gene polymorphisms are related to the development of gastric and duodenal ulcer and may determine disease outcome in H. pylori infection...
  20. pmc Risk of upper gastrointestinal ulcer bleeding associated with selective cyclo-oxygenase-2 inhibitors, traditional non-aspirin non-steroidal anti-inflammatory drugs, aspirin and combinations
    A Lanas
    Servicio de Aparato Digestivo, Hospital Clinico Universitario, Zaragoza 50009, Spain
    Gut 55:1731-8. 2006
    ..The risks and benefits of coxibs, non-steroidal anti-inflammatory drugs (NSAIDs), and aspirin treatment are under intense debate...
  21. ncbi request reprint Characterization of the prostaglandin E2 pathway in a rat model of esophageal adenocarcinoma
    E Piazuelo
    IIS Aragón, Aragon Institute of Health Scineces, Zaragoza, Spain
    Curr Cancer Drug Targets 12:132-43. 2012
    ..Esophagojejunostomy with gastric preservation was performed in wistar rats to induce gastroduodenal reflux. Rats were sacrificed 2 or 4 months after surgery. Nine non-operated rats were used to obtain normal (control) esophageal tissues...
  22. ncbi request reprint Risk of upper gastrointestinal bleeding in patients taking low-dose aspirin for the prevention of cardiovascular diseases
    P Serrano
    Service of Cardiology, Hospital Clinico Universitario Lozano Blesa, Zaragoza, Spain
    Aliment Pharmacol Ther 16:1945-53. 2002
    ..Most patients with vascular-occlusive diseases benefit from low-dose aspirin (75-325 mg/day). However, they have an increased risk of upper gastrointestinal bleeding (UGIB)...
  23. ncbi request reprint Effects of long-term cyclo-oxygenase 2 selective and acid inhibition on Barrett's oesophagus
    A Lanas
    Service of Digestive Diseases, University Hospital, Instituto Aragones de Ciencias de la Salud, CIBERehd, Zaragoza, Spain
    Aliment Pharmacol Ther 26:913-23. 2007
    ..There is an overexpression of cyclo-oxygenase 2 (COX-2) in Barrett's oesophagus (BO)...
  24. ncbi request reprint Superoxide anion and nitric oxide in high-grade esophagitis induced by acid and pepsin in rabbits
    A Lanas
    Service of Gastroenterology, University Hospital and University of Zaragoza, Spain
    Dig Dis Sci 46:2733-43. 2001
    ..Superoxide dismutase but not NO-donor-modifying agents might have a therapeutic role in preventing severe esophageal mucosal damage induced by acid and pepsin...
  25. doi request reprint The changing face of hospitalisation due to gastrointestinal bleeding and perforation
    A Lanas
    Hospital Clinico, Universidad de Zaragoza, Spain
    Aliment Pharmacol Ther 33:585-91. 2011
    ..Temporal changes in the incidence of cause-specific gastrointestinal (GI) complications may be one of the factors underlying changing medical practice patterns...
  26. ncbi request reprint Clinical trends in ulcer diagnosis in a population with high prevalence of Helicobacter pylori infection
    M A Perez-Aisa
    Service of Digestive Diseases, University Hospital, Zaragoza, Spain
    Aliment Pharmacol Ther 21:65-72. 2005
    ..It is unknown whether the incidence of peptic ulcer changes in areas with a high prevalence of Helicobacter pylori infection...
  27. doi request reprint Prostaglandin EP2 receptor expression is increased in Barrett's oesophagus and oesophageal adenocarcinoma
    P Jimenez
    CIBER Enfermedades Hepáticas y Digestivas CIBERehd, University Hospital, Zaragoza, Spain
    Aliment Pharmacol Ther 31:440-51. 2010
    ..Accumulating evidence suggests that cyclooxygenase-2 (COX-2)-derived prostaglandin E2 (PGE2) is involved in oesophageal adenocarcinogenesis. PGE2 exerts its biological action by binding to specific receptors (EP1, EP2, EP3 and EP4)...
  28. doi request reprint The aspirin cardiovascular/gastrointestinal risk calculator--a tool to aid clinicians in practice
    A Lanas
    Service of Digestive Diseases, University Hospital Lozano Blesa, University of Zaragoza, IIS Aragón, Spain
    Aliment Pharmacol Ther 37:738-48. 2013
    ..Assessment of both GI and CV risks vs. the benefits of low-dose aspirin for individual patients can be difficult in clinical practice...
  29. doi request reprint Risk factors for advanced lesions undetected at prior colonoscopy: not always poor preparation
    A Ferrandez
    Service of Digestives Diseases, Hospital Clinico Lozano Blesa, CIBERehd, Zaragoza, Spain
    Endoscopy 42:1071-6. 2010
    ..However, adenoma miss rates in tandem colonoscopy studies vary from 2 % to 26 %. We aimed to investigate the rates of advanced neoplasia in patients with a prior normal colonoscopy in an outpatient endoscopy unit...
  30. ncbi request reprint COX-2 inhibition in esophagitis, Barrett's esophagus and esophageal cancer
    E Piazuelo
    Instituto Aragones de Ciencias de la Salud, Hospital Clinico Universitario, Zafagoza, Spain
    Curr Pharm Des 9:2267-80. 2003
    ..Further studies are necessary in order to better understand factors involved in COX-2 up-regulation and mechanisms of COX-2 associated tumorigenesis in the esophagus...
  31. pmc The polymorphic IL-1B and IL-1RN genes in the aetiopathogenesis of peptic ulcer
    M A Garcia-Gonzalez
    Hospital Clínico Universitario and Unidad Mixta de Investigación, Zaragoza, Spain
    Clin Exp Immunol 125:368-75. 2001
    ..37, 95% CI = 0.14-0.9). Our data suggest that IL-1B and IL-1RN genes in addition to bacterial and environmental factors play a key role in determining the final outcome of peptic ulcer disease...
  32. ncbi request reprint [Defense of the esophageal mucosa as a therapeutic target in gastroesophageal reflux disease]
    E Piazuelo
    Instituto Aragones de Ciencias de la Salud, Zaragoza, Espana
    Gastroenterol Hepatol 27:274-84. 2004
  33. ncbi request reprint Nonsteroidal anti-inflammatory drugs, low-dose aspirin, and potential ways of reducing the risk of complications
    A Lanas
    Service of Gastroenterology, University Hospital, Zaragoza, Spain
    Eur J Gastroenterol Hepatol 13:623-6. 2001
    ..Epidemiological studies have also shown that nitric oxide donor drugs reduce the risk of upper GI bleeding, which might be important in patients receiving low-dose aspirin...
  34. doi request reprint Underutilization of gastroprotection for at-risk patients undergoing percutaneous coronary intervention: Spain compared with the United States
    R Casado-Arroyo
    University Hospital Lozano Blesa, Zaragoza, Spain
    Aliment Pharmacol Ther 32:689-95. 2010
    ..Proton pump inhibitors (PPIs) are the preferred agents for the prevention of aspirin-associated upper gastrointestinal bleeding (UGIB). Data are limited to determine whether PPIs are being used to reduce UGIB risk...
  35. doi request reprint Risk factors associated with a decrease ≥2 g/dL in haemoglobin and/or ≥10% haematocrit in osteoarthritis patients taking celecoxib or a nonselective NSAID plus a PPI in a large randomised controlled trial (CONDOR)
    A Lanas
    CIBERehd IIS Aragón, Universidad de Zaragoza, Zaragoza, Spain
    Aliment Pharmacol Ther 36:485-92. 2012
    ..This adverse event is potentially clinically relevant in long-term NSAID treatment...
  36. ncbi request reprint Economic analysis of strategies in the prevention of non-steroidal anti-inflammatory drug-induced complications in the gastrointestinal tract
    A Lanas
    Service of Gastroenterology, Clinic University Hospital, Zaragoza, Spain
    Aliment Pharmacol Ther 20:321-31. 2004
    ..It is unclear what the best therapeutic approach is in patients who require non-steroidal anti-inflammatory drugs. In clinical practice, choice of prescriptions are often based on drug costs...
  37. ncbi request reprint NSAIDs-induced gastrointestinal damage. Review
    M Arroyo
    Service of Gastroenterology, University Hospital of Zaragoza, Zaragoza, Spain
    Minerva Gastroenterol Dietol 52:249-59. 2006
    ....
  38. ncbi request reprint Diaphragm disease of the small bowel: a case without apparent nonsteroidal antiinflammatory drug use
    S Santolaria
    Service of Gastroenterology, University Hospital Lozano Blesa, Zaragoza, Spain
    J Clin Gastroenterol 32:344-6. 2001
    ..CONCLUSIONS: We suggest that diaphragm-like strictures might be developed as a nonspecific response to different damaging insults to the intestine and are not necessarily associated with NSAID use...
  39. doi request reprint Clinical predictors of poor outcomes among patients with nonvariceal upper gastrointestinal bleeding in Europe
    A Lanas
    Gastroenterology, University of Zaragoza, Servicio de Aparato Digestivo, Hospital Clinico Universitario Lozano Blesa, C Domingo Miral s n, Zaragoza, Spain
    Aliment Pharmacol Ther 33:1225-33. 2011
    ..Despite advances in endoscopic and pharmacological treatment during the past two decades, the incidence of mortality associated with NVUGIB has remained relatively constant...
  40. pmc Helicobacter pylori stimulates pepsinogen secretion from isolated human peptic cells
    S Lorente
    Service of Gastroenterology, University Hospital, Zaragoza, Spain
    Gut 50:13-8. 2002
    ..Patients with H pylori associated gastritis or duodenal ulcer have increased serum pepsinogen levels which decrease after eradication. The mechanisms of H pylori induced gastric mucosal damage are not completely understood...
  41. ncbi request reprint Prevention of anti-inflammatory drug-induced gastrointestinal damage: benefits and risks of therapeutic strategies
    Angel Lanas
    Instituto Aragones de Ciencias de la Salud, Service of Gastroenterology, University Hospital, Zaragoza, Spain
    Ann Med 38:415-28. 2006
    ..A PPI+coxib is indicated in those at highest risk (e.g. previous ulcer bleeding). PPI therapy must be considered for the treatment and prevention of NSAID-induced dyspepsia...
  42. ncbi request reprint A randomized trial of rofecoxib for the chemoprevention of colorectal adenomas
    John A Baron
    Department of Medicine, The Norris Cotton Cancer Center, Dartmouth Medical School, Hanover, New Hampshire, USA
    Gastroenterology 131:1674-82. 2006
    ..We conducted a randomized, placebo-controlled, double-blind trial to assess whether use of the selective COX-2 inhibitor rofecoxib would reduce the risk of colorectal adenomas...
  43. ncbi request reprint Low-dose aspirin and upper gastrointestinal damage: epidemiology, prevention and treatment
    Angel Lanas
    Service of Gastroenterology, Instituto Aragones de Ciencias de la Salud, University Hospital, Zaragoza, Spain
    Curr Med Res Opin 23:163-73. 2007
    ..However, due to its action on cyclo-oxygenase (COX), aspirin is associated with upper gastrointestinal (GI) side effects including ulcers and bleeding...
  44. ncbi request reprint Effects of selective PGE2 receptor antagonists in esophageal adenocarcinoma cells derived from Barrett's esophagus
    Elena Piazuelo
    Instituto Aragones de Ciencias de la Salud, Zaragoza, Spain
    Prostaglandins Other Lipid Mediat 81:150-61. 2006
    ..These findings suggest a potential role for EP selective antagonists in the treatment of esophageal adenocarcinoma...
  45. ncbi request reprint Inappropriate prevention of NSAID-induced gastrointestinal events among long-term users in the elderly
    Angel Lanas
    Service of Digestive Diseases, University Hospital, Instituto Aragones de Ciencias de la Salud CIBER HEPAD, University of Zaragoza, Zaragoza, Spain
    Drugs Aging 24:121-31. 2007
    ..In summary, aging is a key risk factor for GI complications in patients taking NSAIDs. Appropriate prevention strategies should be used in the elderly and those at risk; special attention should be paid to compliance and self-medication...
  46. ncbi request reprint Effect of antisecretory drugs and nitrates on the risk of ulcer bleeding associated with nonsteroidal anti-inflammatory drugs, antiplatelet agents, and anticoagulants
    Angel Lanas
    Servicio de Aparato Digestivo, Hospital Clinico Zaragoza, CIBER HEPAD, Zaragoza, Spain
    Am J Gastroenterol 102:507-15. 2007
    ..Here, we report the effect of antisecretory drugs and nitrates on the risk of upper GI peptic ulcer bleeding (UGIB) associated with nonselective NSAIDs, aspirin, antiplatelet agents, and anticoagulants...
  47. ncbi request reprint [Chemoprevention in adenocarcinoma of the esophagus]
    Angel Lanas
    Servicio de Aparato Digestivo, Hospital Clinico Universitario, Zaragoza, Espana
    Acta Gastroenterol Latinoam 37:37-48. 2007
    ....
  48. ncbi request reprint Gastric cancer susceptibility is not linked to pro-and anti-inflammatory cytokine gene polymorphisms in whites: a Nationwide Multicenter Study in Spain
    María Asunción García-Gonzalez
    Instituto Aragones de Ciencias de la Salud, Zaragoza, Spain
    Am J Gastroenterol 102:1878-92. 2007
    ..Our goal was to evaluate the influence of Helicobacter pylori (H. pylori) infection and host genetic factors on GC susceptibility in a population of Spanish white GC patients...
  49. ncbi request reprint Improving on our goal to reduce NSAID-induced GI complications: a challenging task?
    Angel Lanas
    Am J Gastroenterol 103:1104-5. 2008
    ..In order to more effectively pursue this goal, we will need to develop new and more complex approaches...
  50. doi request reprint Efficacy of esomeprazole (20 mg once daily) for reducing the risk of gastroduodenal ulcers associated with continuous use of low-dose aspirin
    Neville Yeomans
    School of Medicine, University of Western Sydney, Sydney, Australia
    Am J Gastroenterol 103:2465-73. 2008
    ..This study determined the efficacy of esomeprazole for reducing the risk of gastric and/or duodenal ulcers and dyspeptic symptoms in patients receiving continuous, low-dose aspirin therapy...
  51. ncbi request reprint Consensus development conference on the use of nonsteroidal anti-inflammatory agents, including cyclooxygenase-2 enzyme inhibitors and aspirin
    C Mel Wilcox
    Department of Internal Medicine, University of Alabama at Birmingham, Birmingham, Alabama, USA
    Clin Gastroenterol Hepatol 4:1082-9. 2006
  52. ncbi request reprint [Prevention and treatment of non-steroidal anti-inflammatory drug gastroenteropathy]
    Angel Lanas
    Sección de Gastroenterología, Servicio de Aparato Digestivo, Hospital Clinico Universitario, Universidad de Zaragoza, Zaragoza, Espana
    Rev Gastroenterol Mex 69:251-60. 2004
    ..In patients at very high risk, co-prescription of coxib with proton pump inhibitors has been recommended. In patients at risk, all these strategies are cost-effective...
  53. ncbi request reprint Celecoxib versus diclofenac and omeprazole to prevent recurrent ulcer bleeding
    Angel Lanas
    N Engl J Med 348:2464-6; author reply 2464-6. 2003
  54. ncbi request reprint The prevalence of peptic ulcer not related to Helicobacter pylori or non-steroidal anti-inflammatory drug use is negligible in southern Europe
    M Teresa Arroyo
    Service of Gastroenterology, Hospital Clinico, Zaragoza, Spain
    Helicobacter 9:249-54. 2004
    ..We investigated the frequency of H. pylori-negative peptic ulcer without intake of nonsteroidal anti-inflammatory drugs (NSAIDs) in a Mediterranean European country...
  55. ncbi request reprint Lack of association of IL-12 p40 gene polymorphism with peptic ulcer disease
    María A García-González
    Instituto Aragonés de Ciencias de la Salud and Department of Gastroenterology, Hospital Clinico Universitario Lozano Blesa, Zaragoza, Spain
    Hum Immunol 66:72-6. 2005
    ..Our data reveal that the IL12B 1188 (A-->C) gene polymorphism is not involved in defining the genetic basis of the susceptibility to and final outcome of peptic ulcer disease...
  56. ncbi request reprint Association of Helicobacter pylori-related distal gastric cancer with the HLA class II gene DQB10602 and cagA strains in a southern European population
    Enrique Quintero
    Gastroenterology Department, University Hospital of the Canary Islands, Spain
    Helicobacter 10:12-21. 2005
    ..In the present study we evaluated the influence of host HLA DQA1 and DQB1 loci, H. pylori genotype, and socio-economic factors on predicting H. pylori-associated distal gastric cancer in a southern European population...
  57. ncbi request reprint Cardiovascular events associated with rofecoxib in a colorectal adenoma chemoprevention trial
    Robert S Bresalier
    Department of Gastrointestinal Medicine and Nutrition, University of Texas M D Anderson Cancer Center, Houston 77030 4009, USA
    N Engl J Med 352:1092-102. 2005
    ....
  58. ncbi request reprint Selective COX-2 inhibition is associated with decreased mucosal damage induced by acid and pepsin in rabbit esophagitis
    Angel Lanas
    Service of Digestive Diseases, Unit of Gastrointestinal Research, University Hospital, Unidad Mixta de Investigacion, Zaragoza, Spain
    Inflammation 27:21-9. 2003
    ..To evaluate the effects of COX-1 and/or COX-2 inhibition in a model of chronic esophagitis in rabbits...
  59. ncbi request reprint Free radicals and antioxidant systems in reflux esophagitis and Barrett's esophagus
    Pilar Jimenez
    Aragonés Institute of Health Sciences, and Gastroenterology Service, Lozano Blesa University Hospital Clinic, Avenida San Juan Bosco, C Domingo Miral, s n 15 50009 Zaragoza, Spain
    World J Gastroenterol 11:2697-703. 2005
    ..Experimental studies suggest that free radicals are involved in acid and pepsin-induced damage of esophageal mucosa. The profile and balance between free radicals and antioxidant systems in human esophagitis are unknown...
  60. ncbi request reprint Bleeding duodenal ulcer and association with polymorphism of endothelial constitutive nitric oxide synthase gene
    Trinidad Serrano
    Service of Gastroenterology, Research Unit, University Hospital, Zaragoza, Spain
    Dig Dis Sci 47:996-1000. 2002
    ..49; 95% CI = 0.25-0.95; P = 0.03). In conclusion, this ecNOS4 polymorphism gene could be related to susceptibility of duodenal ulcer patients to bleeding...
  61. ncbi request reprint Gastrointestinal injury from NSAID therapy. How to reduce the risk of complications
    Angel Lanas
    Service of Gastroenterology, University Hospital, Institute of Health Sciences of Aragon, Zaragoza, Spain
    Postgrad Med 117:23-8, 31. 2005
    ..In this article, Dr Lanas summarizes the GI risks associated with NSAID and low-dose aspirin therapy and weighs the efficacy of current risk management strategies...
  62. ncbi request reprint Atypical and aggressive upper gastrointestinal ulceration associated with aspirin abuse
    Basil I Hirschowitz
    Division of Gastroenterology and Hepatology, University of Alabama at Birmingham, UAB Station, Birmingham, AL 35294 0007, USA
    J Clin Gastroenterol 34:523-8. 2002
    ..Although some ulcers were caused by Zollinger-Ellison syndrome (ZES), an atypical clinical course in other patients, especially with those with multiple ulcers, suggested abuse of aspirin...
  63. ncbi request reprint A nationwide study of mortality associated with hospital admission due to severe gastrointestinal events and those associated with nonsteroidal antiinflammatory drug use
    Angel Lanas
    Servicio de Aparato Digestivo, Hospital Clinico Zaragoza, Zaragoza, Spain
    Am J Gastroenterol 100:1685-93. 2005
    ..The worst outcome of gastrointestinal complications is death. Data regarding those associated with nonsteroidal antiinflammatory drug (NSAID) or aspirin use are scarce...
  64. ncbi request reprint Potent gastric acid inhibition in the management of Barrett's oesophagus
    Angel Lanas
    Gastroenterology Service, Clinical University Hospital, Zaragoza, Spain
    Drugs 65:75-82. 2005
    ..This therapeutic approach should be still regarded as experimental and more data are needed before its therapeutic role in patients with Barrett's oesophagus is established...
  65. ncbi request reprint Superoxide dismutase prevents development of adenocarcinoma in a rat model of Barrett's esophagus
    Elena Piazuelo
    Instituto Aragones de Ciencias de la Salud, Unidad Mixta de Investigacion, Zaragoza, Spain
    World J Gastroenterol 11:7436-43. 2005
    ..To test whether antioxidant treatment could prevent the progression of Barrett's esophagus to adenocarcinoma...
  66. pmc CagA-positive Helicobacter pylori infection is not associated with decreased risk of Barrett's esophagus in a population with high H. pylori infection rate
    Angel Ferrandez
    Gastrointestinal Oncology Unit, Service of Digestive Diseases, Hospital Clinico Lozano Blesa, Zaragoza, Spain
    BMC Gastroenterol 6:7. 2006
    ..The role that H. pylori infection plays in the development of and Barrett's esophagus (BE) is uncertain. We tested the hypothesis that infection with cagA+ Helicobacter pylori strains protects against the development of BE...
  67. ncbi request reprint Microbial flora in NSAID-induced intestinal damage: a role for antibiotics?
    Angel Lanas
    Servicio de Aparato Digestivo, Hospital Clinico Universitario, Zaragoza, Spain
    Digestion 73:136-50. 2006
    ..The availability of poorly absorbed and effective antibiotics, like rifaximin, may represent an attractive alternative to prevent or limit NSAID-associated intestinal damage...
  68. ncbi request reprint NSAID-induced gastrointestinal damage: current clinical management and recommendations for prevention
    Angel Lanas
    Service of Gastroenterology, University Hospital of Zaragoza, Spain
    Chin J Dig Dis 7:127-33. 2006
    ....
  69. ncbi request reprint Treatment and prevention of aspirin-induced gastroduodenal ulcers and gastrointestinal bleeding
    Angel Lanas
    Service of Gastroenterology, University Hospital Lozano Blesa, Zaragoza, Spain
    Expert Opin Drug Saf 1:245-52. 2002
    ..The role of Helicobacter pylori is controversial in NSAID users, but there is now wide agreement that H. pylori infection increases mucosal damage and the risk of upper GI bleeding in low-dose aspirin users...
  70. ncbi request reprint Clinical implications of COX-1 and/or COX-2 inhibition for the distal gastrointestinal tract
    Angel Lanas
    Service of Digestive Diseases, University Hospital Lozano Blesa Zaragoza Spain
    Curr Pharm Des 9:2253-66. 2003
    ..However, current epidemiological and clinical data are contradictory. Since many patients...
  71. ncbi request reprint Association between achalasia and nitric oxide synthase gene polymorphisms
    Fermin Mearin
    Institute of Functional and Motor Digestive Disorders, Centro Medico Teknon, Barcelona, Spain
    Am J Gastroenterol 101:1979-84. 2006
    ..NOS exists in three distinct isoforms: neuronal NOS (nNOS), endothelial NOS (eNOS), and inducible isoform (iNOS). Some studies have shown that NO production is regulated by NOS polymorphisms...
  72. ncbi request reprint Benefits, problems and alternatives to COX-2 inhibition
    Angel Lanas
    Curr Top Med Chem 5:441-2. 2005
  73. ncbi request reprint Genomic rearrangements in MSH2 and MLH1 are rare mutational events in Spanish patients with hereditary nonpolyposis colorectal cancer
    Sergi Castellvi-Bel
    Gastroenterology Department, Institut de Malalties Digestives, IDIBAPS, Barcelona, Catalonia, Spain
    Cancer Lett 225:93-8. 2005
    ..These results showed that MSH2/MLH1 rearrangements in Spanish patients at risk for HNPCC seem to be a less frequent mutational event than in other populations...
  74. ncbi request reprint [Gastrointestinal and cardiovascular side effects associated with COX-2 selective inhibitors]
    Angel Lanas
    Med Clin (Barc) 118:237-8. 2002