Jose M Jimenez-Lopez

Summary

Affiliation: University of Granada
Country: Spain

Publications

  1. ncbi Alterations in the homeostasis of phospholipids and cholesterol by antitumor alkylphospholipids
    Jose M Jimenez-Lopez
    Department of Biochemistry and Molecular Biology I, Faculty of Sciences, University of Granada, Av, Fuentenueva s n, Granada, Spain
    Lipids Health Dis 9:33. 2010
  2. ncbi Synergistic toxicity induced by prolonged glutathione depletion and inhibition of nuclear factor-kappaB signaling in liver cells
    Jose M Jimenez-Lopez
    Department of Pharmacology and Systems Therapeutics, Mount Sinai School of Medicine, New York, NY 10029, USA
    Toxicol In Vitro 22:106-15. 2008
  3. ncbi Green tea polyphenol epigallocatechin-3-gallate protects HepG2 cells against CYP2E1-dependent toxicity
    Jose M Jimenez-Lopez
    Department of Pharmacology and Biological Chemistry, Mount Sinai School of Medicine, New York, NY 10029, USA
    Free Radic Biol Med 36:359-70. 2004
  4. ncbi Hexadecylphosphocholine interferes with the intracellular transport of cholesterol in HepG2 cells
    María P Carrasco
    Department of Biochemistry and Molecular Biology I, Faculty of Sciences, University of Granada, Avenida Fuentenueva s n, Granada, Spain
    FEBS J 275:1675-86. 2008
  5. ncbi Protein kinase C signaling as a survival pathway against CYP2E1-derived oxidative stress and toxicity in HepG2 cells
    Jose M Jimenez-Lopez
    Department of Pharmacology and Biological Chemistry, Box 1603, Mount Sinai School of Medicine, One Gustave L. Levy Place, New York, NY 10029, USA
    J Pharmacol Exp Ther 312:998-1006. 2005
  6. ncbi CYP2E1-dependent oxidative stress and toxicity: role in ethanol-induced liver injury
    Jose M Jimenez-Lopez
    Mount Sinai School of Medicine, Department of Pharmacology and Biological Chemistry, New York, NY 10029, USA
    Expert Opin Drug Metab Toxicol 1:671-85. 2005

Collaborators

Detail Information

Publications6

  1. ncbi Alterations in the homeostasis of phospholipids and cholesterol by antitumor alkylphospholipids
    Jose M Jimenez-Lopez
    Department of Biochemistry and Molecular Biology I, Faculty of Sciences, University of Granada, Av, Fuentenueva s n, Granada, Spain
    Lipids Health Dis 9:33. 2010
    ..Alkylphospholipid-induced alterations in lipid homeostasis with probable disturbance of the native membrane structure could well affect signaling processes vital to cell survival and growth...
  2. ncbi Synergistic toxicity induced by prolonged glutathione depletion and inhibition of nuclear factor-kappaB signaling in liver cells
    Jose M Jimenez-Lopez
    Department of Pharmacology and Systems Therapeutics, Mount Sinai School of Medicine, New York, NY 10029, USA
    Toxicol In Vitro 22:106-15. 2008
    ..In summary, inhibition of NF-kappaB sensitizes liver cells to toxicity linked to GSH depletion, probably accelerating the processes of thiol homeostasis deregulation and induction of apoptosis through a mechanism mediated by p38 MAPK...
  3. ncbi Green tea polyphenol epigallocatechin-3-gallate protects HepG2 cells against CYP2E1-dependent toxicity
    Jose M Jimenez-Lopez
    Department of Pharmacology and Biological Chemistry, Mount Sinai School of Medicine, New York, NY 10029, USA
    Free Radic Biol Med 36:359-70. 2004
    ....
  4. ncbi Hexadecylphosphocholine interferes with the intracellular transport of cholesterol in HepG2 cells
    María P Carrasco
    Department of Biochemistry and Molecular Biology I, Faculty of Sciences, University of Granada, Avenida Fuentenueva s n, Granada, Spain
    FEBS J 275:1675-86. 2008
    ....
  5. ncbi Protein kinase C signaling as a survival pathway against CYP2E1-derived oxidative stress and toxicity in HepG2 cells
    Jose M Jimenez-Lopez
    Department of Pharmacology and Biological Chemistry, Box 1603, Mount Sinai School of Medicine, One Gustave L. Levy Place, New York, NY 10029, USA
    J Pharmacol Exp Ther 312:998-1006. 2005
    ..In conclusion, PKC activation by TPA prevents CYP2E1-derived acute oxidative stress and toxicity in HepG2 cells, and this appears to involve maintenance of the intracellular redox homeostasis via PKC signal transduction...
  6. ncbi CYP2E1-dependent oxidative stress and toxicity: role in ethanol-induced liver injury
    Jose M Jimenez-Lopez
    Mount Sinai School of Medicine, Department of Pharmacology and Biological Chemistry, New York, NY 10029, USA
    Expert Opin Drug Metab Toxicol 1:671-85. 2005
    ..Future directions, which may help to better understand the actions of CYP2E1 and its role in alcoholic liver injury, are suggested...