Jose M Jimenez-Lopez

Summary

Affiliation: University of Granada
Country: Spain

Publications

  1. pmc Alterations in the homeostasis of phospholipids and cholesterol by antitumor alkylphospholipids
    Jose M Jimenez-Lopez
    Department of Biochemistry and Molecular Biology I, Faculty of Sciences, University of Granada, Av, Fuentenueva s n, Granada, Spain
    Lipids Health Dis 9:33. 2010
  2. pmc Synergistic toxicity induced by prolonged glutathione depletion and inhibition of nuclear factor-kappaB signaling in liver cells
    Jose M Jimenez-Lopez
    Department of Pharmacology and Systems Therapeutics, Mount Sinai School of Medicine, New York, NY 10029, USA
    Toxicol In Vitro 22:106-15. 2008
  3. pmc Disruption of cellular cholesterol transport and homeostasis as a novel mechanism of action of membrane-targeted alkylphospholipid analogues
    María P Carrasco
    Department of Biochemistry and Molecular Biology I, University of Granada, Spain
    Br J Pharmacol 160:355-66. 2010
  4. doi request reprint Lipid efflux mediated by alkylphospholipids in HepG2 cells
    Pablo Ríos-Marco
    Department of Biochemistry and Molecular Biology I, Faculty of Sciences, University of Granada, Granada, Spain
    Cell Biochem Biophys 66:737-46. 2013
  5. ncbi request reprint Hexadecylphosphocholine disrupts cholesterol homeostasis and induces the accumulation of free cholesterol in HepG2 tumour cells
    Jose M Jimenez-Lopez
    Department of Biochemistry and Molecular Biology, Faculty of Sciences, University of Granada, Spain
    Biochem Pharmacol 71:1114-21. 2006
  6. doi request reprint Hexadecylphosphocholine interferes with the intracellular transport of cholesterol in HepG2 cells
    María P Carrasco
    Department of Biochemistry and Molecular Biology I, Faculty of Sciences, University of Granada, Avenida Fuentenueva s n, Granada, Spain
    FEBS J 275:1675-86. 2008
  7. ncbi request reprint Green tea polyphenol epigallocatechin-3-gallate protects HepG2 cells against CYP2E1-dependent toxicity
    Jose M Jimenez-Lopez
    Department of Pharmacology and Biological Chemistry, Mount Sinai School of Medicine, New York, NY 10029, USA
    Free Radic Biol Med 36:359-70. 2004
  8. doi request reprint Antitumoral alkylphospholipids induce cholesterol efflux from the plasma membrane in HepG2 cells
    Pablo Ríos-Marco
    Department of Biochemistry and Molecular Biology I, Faculty of Sciences, University of Granada, Granada, Spain
    J Pharmacol Exp Ther 336:866-73. 2011
  9. doi request reprint Hexadecylphosphocholine alters nonvesicular cholesterol traffic from the plasma membrane to the endoplasmic reticulum and inhibits the synthesis of sphingomyelin in HepG2 cells
    Carmen Marco
    Department of Biochemistry and Molecular Biology I, Faculty of Sciences, University of Granada, Av Fuentenueva S N, Granada 18001, Spain
    Int J Biochem Cell Biol 41:1296-303. 2009
  10. ncbi request reprint Ethanol specifically alters the synthesis, acylation and transbilayer movement of aminophospholipids in rat-liver microsomes
    María P Carrasco
    Department of Biochemistry and Molecular Biology, Faculty of Sciences, University of Granada, Av Fuentenueva S N, Granada 18001, Spain
    Life Sci 78:2781-6. 2006

Collaborators

Detail Information

Publications17

  1. pmc Alterations in the homeostasis of phospholipids and cholesterol by antitumor alkylphospholipids
    Jose M Jimenez-Lopez
    Department of Biochemistry and Molecular Biology I, Faculty of Sciences, University of Granada, Av, Fuentenueva s n, Granada, Spain
    Lipids Health Dis 9:33. 2010
    ..Alkylphospholipid-induced alterations in lipid homeostasis with probable disturbance of the native membrane structure could well affect signaling processes vital to cell survival and growth...
  2. pmc Synergistic toxicity induced by prolonged glutathione depletion and inhibition of nuclear factor-kappaB signaling in liver cells
    Jose M Jimenez-Lopez
    Department of Pharmacology and Systems Therapeutics, Mount Sinai School of Medicine, New York, NY 10029, USA
    Toxicol In Vitro 22:106-15. 2008
    ..In summary, inhibition of NF-kappaB sensitizes liver cells to toxicity linked to GSH depletion, probably accelerating the processes of thiol homeostasis deregulation and induction of apoptosis through a mechanism mediated by p38 MAPK...
  3. pmc Disruption of cellular cholesterol transport and homeostasis as a novel mechanism of action of membrane-targeted alkylphospholipid analogues
    María P Carrasco
    Department of Biochemistry and Molecular Biology I, University of Granada, Spain
    Br J Pharmacol 160:355-66. 2010
    ..We now extended our studies to analyse the effects of other clinically relevant APLs, such as edelfosine, erucylphosphocholine and perifosine on intracellular cholesterol homeostasis...
  4. doi request reprint Lipid efflux mediated by alkylphospholipids in HepG2 cells
    Pablo Ríos-Marco
    Department of Biochemistry and Molecular Biology I, Faculty of Sciences, University of Granada, Granada, Spain
    Cell Biochem Biophys 66:737-46. 2013
    ..Thus, the findings of this study clearly demonstrate that antitumoural APLs act as extracellular acceptors, stimulating cholesterol and phospholipid efflux, although they may also play a role as cholesterol donors. ..
  5. ncbi request reprint Hexadecylphosphocholine disrupts cholesterol homeostasis and induces the accumulation of free cholesterol in HepG2 tumour cells
    Jose M Jimenez-Lopez
    Department of Biochemistry and Molecular Biology, Faculty of Sciences, University of Granada, Spain
    Biochem Pharmacol 71:1114-21. 2006
    ....
  6. doi request reprint Hexadecylphosphocholine interferes with the intracellular transport of cholesterol in HepG2 cells
    María P Carrasco
    Department of Biochemistry and Molecular Biology I, Faculty of Sciences, University of Granada, Avenida Fuentenueva s n, Granada, Spain
    FEBS J 275:1675-86. 2008
    ....
  7. ncbi request reprint Green tea polyphenol epigallocatechin-3-gallate protects HepG2 cells against CYP2E1-dependent toxicity
    Jose M Jimenez-Lopez
    Department of Pharmacology and Biological Chemistry, Mount Sinai School of Medicine, New York, NY 10029, USA
    Free Radic Biol Med 36:359-70. 2004
    ....
  8. doi request reprint Antitumoral alkylphospholipids induce cholesterol efflux from the plasma membrane in HepG2 cells
    Pablo Ríos-Marco
    Department of Biochemistry and Molecular Biology I, Faculty of Sciences, University of Granada, Granada, Spain
    J Pharmacol Exp Ther 336:866-73. 2011
    ..Thus, we have found that antitumoral APLs efficiently deplete membrane cholesterol, which may be one important factor in determining the early biological actions of APLs...
  9. doi request reprint Hexadecylphosphocholine alters nonvesicular cholesterol traffic from the plasma membrane to the endoplasmic reticulum and inhibits the synthesis of sphingomyelin in HepG2 cells
    Carmen Marco
    Department of Biochemistry and Molecular Biology I, Faculty of Sciences, University of Granada, Av Fuentenueva S N, Granada 18001, Spain
    Int J Biochem Cell Biol 41:1296-303. 2009
    ..Since sphingomyelin and cholesterol are major lipid constituents of membrane raft microdomains, these results suggest that hexadecylphosphocholine could disturb membrane raft integrity and thence its functionality...
  10. ncbi request reprint Ethanol specifically alters the synthesis, acylation and transbilayer movement of aminophospholipids in rat-liver microsomes
    María P Carrasco
    Department of Biochemistry and Molecular Biology, Faculty of Sciences, University of Granada, Av Fuentenueva S N, Granada 18001, Spain
    Life Sci 78:2781-6. 2006
    ..Bearing in mind that if a membrane is to function properly its structure must be in optimum condition; it is evident that the observed processes may be responsible to some degree for the pathophysiological effects of alcohol upon cells...
  11. ncbi request reprint Hexadecylphosphocholine inhibits phosphatidylcholine synthesis via both the methylation of phosphatidylethanolamine and CDP-choline pathways in HepG2 cells
    Jose M Jimenez-Lopez
    Department of Biochemistry and Molecular Biology, Faculty of Sciences, University of Granada, Granada 18001, Spain
    Int J Biochem Cell Biol 36:153-61. 2004
    ..On the contrary, in the presence of HePC both pathways seem to contribute jointly to a decrease in the overall synthesis of PC in HepG2 cells...
  12. ncbi request reprint Resistance of HepG2 cells against the adverse effects of ethanol related to neutral lipid and phospholipid metabolism
    Jose M Jimenez-Lopez
    Faculty of Sciences, Department of Biochemistry and Molecular Biology, University of Granada, Avenida Fuentenueva s n, Granada 18001, Spain
    Biochem Pharmacol 63:1485-90. 2002
    ....
  13. ncbi request reprint Effects of ethanol on the remodeling of neutral lipids and phospholipids in brain mitochondria and microsomes
    María P Carrasco
    Department of Biochemistry and Molecular Biology, Faculty of Sciences, University of Granada, Av Fuentenueva S N, Granada 18001, Spain
    Neurochem Int 50:858-65. 2007
    ..In both types of membrane, FAEE production was lowest with the monounsaturated fatty acyl-CoA...
  14. ncbi request reprint Hexadecylphosphocholine inhibits phosphatidylcholine biosynthesis and the proliferation of HepG2 cells
    Jose M Jimenez-Lopez
    Department of Biochemistry and Molecular Biology, Faculty of Sciences, University of Granada, Spain
    Eur J Biochem 269:4649-55. 2002
    ..Taken together our results suggest that HePC interferes specifically with the biosynthesis of PC in HepG2 cells by depressing CT translocation to the membrane, which may well impair their proliferation...
  15. ncbi request reprint Antitumoral alkylphospholipids alter cell lipid metabolism
    Carmen Marco
    Department of Biochemistry and Molecular Biology I, Faculty of Sciences, University of Granada, Av Fuentenueva S N, Granada 18001, Spain
    Anticancer Agents Med Chem 14:545-58. 2014
    ....
  16. ncbi request reprint CYP2E1-dependent oxidative stress and toxicity: role in ethanol-induced liver injury
    Jose M Jimenez-Lopez
    Mount Sinai School of Medicine, Department of Pharmacology and Biological Chemistry, New York, NY 10029, USA
    Expert Opin Drug Metab Toxicol 1:671-85. 2005
    ..Future directions, which may help to better understand the actions of CYP2E1 and its role in alcoholic liver injury, are suggested...
  17. ncbi request reprint Protein kinase C signaling as a survival pathway against CYP2E1-derived oxidative stress and toxicity in HepG2 cells
    Jose M Jimenez-Lopez
    Department of Pharmacology and Biological Chemistry, Box 1603, Mount Sinai School of Medicine, One Gustave L Levy Place, New York, NY 10029, USA
    J Pharmacol Exp Ther 312:998-1006. 2005
    ..In conclusion, PKC activation by TPA prevents CYP2E1-derived acute oxidative stress and toxicity in HepG2 cells, and this appears to involve maintenance of the intracellular redox homeostasis via PKC signal transduction...