Antonio Gonzalez

Summary

Affiliation: University of Extremadura
Country: Spain

Publications

  1. doi request reprint Cinnamtannin B-1, a natural antioxidant that reduces the effects of H(2)O(2) on CCK-8-evoked responses in mouse pancreatic acinar cells
    Antonio Gonzalez
    Department of Physiology Cell Physiology Research Group, University of Extremadura, Caceres, Spain
    J Physiol Biochem 68:181-91. 2012
  2. ncbi request reprint Effect of xanthine oxidase-catalyzed reactive oxygen species generation on secretagogue-evoked calcium mobilization in mouse pancreatic acinar cells
    A González-Mateos
    Department of Physiology, University of Extremadura, Faculty of Veterinary Sciences, P O Box 643, 10071, Caceres, Spain
    Biochem Pharmacol 62:1621-7. 2001
  3. ncbi request reprint Ethanol impairs CCK-8-evoked amylase secretion through Ca2+-mediated ROS generation in mouse pancreatic acinar cells
    Antonio Gonzalez
    Department of Physiology, Faculty of Veterinary Sciences, University of Extremadura, Avenida Universidad s n, E 10071, Caceres, Spain
    Alcohol 38:51-7. 2006
  4. ncbi request reprint Ethanol stimulates ROS generation by mitochondria through Ca2+ mobilization and increases GFAP content in rat hippocampal astrocytes
    Antonio Gonzalez
    Department of Physiology Cell Physiology Research Group, University of Extremadura, Caceres, Spain
    Brain Res 1178:28-37. 2007
  5. ncbi request reprint H2O2-induced changes in mitochondrial activity in isolated mouse pancreatic acinar cells
    Antonio Gonzalez
    Department of Physiology, Faculty of Veterinary Sciences, University of Extremadura, Caceres, Spain
    Mol Cell Biochem 269:165-73. 2005
  6. doi request reprint Ethanol impairs calcium homeostasis following CCK-8 stimulation in mouse pancreatic acinar cells
    Antonio Gonzalez
    Department of Physiology, Cell Physiology Research Group, Faculty of Veterinary Sciences, University of Extremadura, Avenida Universidad s n, PO Box 643, Caceres, Spain
    Alcohol 42:565-73. 2008
  7. ncbi request reprint Changes in mitochondrial activity evoked by cholecystokinin in isolated mouse pancreatic acinar cells
    Antonio Gonzalez
    Faculty of Veterinary Sciences, Department of Physiology, University of Extremadura, Avenida Universidad s n E 10071, Caceres, Spain
    Cell Signal 15:1039-48. 2003
  8. doi request reprint Melatonin reduces pancreatic tumor cell viability by altering mitochondrial physiology
    Antonio Gonzalez
    Department of Physiology, Cell Physiology Research Group, University of Extremadura, Caceres, Spain
    J Pineal Res 50:250-60. 2011
  9. ncbi request reprint XOD-catalyzed ROS generation mobilizes calcium from intracellular stores in mouse pancreatic acinar cells
    Antonio Gonzalez
    Department of Physiology, Faculty of Veterinary Sciences, University of Extremadura, P O Box 643 10071, Caceres, Spain
    Cell Signal 14:153-9. 2002
  10. ncbi request reprint H2O2 mobilizes Ca2+ from agonist- and thapsigargin-sensitive and insensitive intracellular stores and stimulates glutamate secretion in rat hippocampal astrocytes
    Antonio Gonzalez
    Department of Physiology, University of Extremadura, Avenida Universidad s n, E 10071 Cáceres, Spain
    Neurochem Res 31:741-50. 2006

Collaborators

  • Gines M Salido
  • Juan A Rosado
  • J A Pariente
  • Adrian Llerena
  • Juan L Acero
  • Pedro Dorado
  • Patricia Santofimia-Castaño
  • Angel del Castillo-Vaquero
  • María P Granados
  • Miguel Salazar
  • Jose A Tapia
  • Lourdes García-Sanchez
  • Pedro C Redondo
  • Marcela Fernández-Sánchez
  • Maria A Martinez-Burgos
  • Maria D Yago
  • Mariano Mañas
  • Emilio Martinez-Victoria
  • Maria A Martinez
  • Ana I Lajas
  • Alvaro Miro-Moran
  • A González-Mateos
  • P J Camello

Detail Information

Publications28

  1. doi request reprint Cinnamtannin B-1, a natural antioxidant that reduces the effects of H(2)O(2) on CCK-8-evoked responses in mouse pancreatic acinar cells
    Antonio Gonzalez
    Department of Physiology Cell Physiology Research Group, University of Extremadura, Caceres, Spain
    J Physiol Biochem 68:181-91. 2012
    ..Our results support the beneficial effect of natural antioxidants in the therapy against oxidative stress-derived deleterious effects on cellular physiology...
  2. ncbi request reprint Effect of xanthine oxidase-catalyzed reactive oxygen species generation on secretagogue-evoked calcium mobilization in mouse pancreatic acinar cells
    A González-Mateos
    Department of Physiology, University of Extremadura, Faculty of Veterinary Sciences, P O Box 643, 10071, Caceres, Spain
    Biochem Pharmacol 62:1621-7. 2001
    ..The possible XOD inhibitory mechanism on Ca(2+) mobilization by agonists is discussed...
  3. ncbi request reprint Ethanol impairs CCK-8-evoked amylase secretion through Ca2+-mediated ROS generation in mouse pancreatic acinar cells
    Antonio Gonzalez
    Department of Physiology, Faculty of Veterinary Sciences, University of Extremadura, Avenida Universidad s n, E 10071, Caceres, Spain
    Alcohol 38:51-7. 2006
    ..Taken together, our results suggest that ethanol induces generation of ROS by a Ca(2+)-dependent mechanism and reduces CCK-8-evoked amylase secretion in exocrine pancreatic cells...
  4. ncbi request reprint Ethanol stimulates ROS generation by mitochondria through Ca2+ mobilization and increases GFAP content in rat hippocampal astrocytes
    Antonio Gonzalez
    Department of Physiology Cell Physiology Research Group, University of Extremadura, Caceres, Spain
    Brain Res 1178:28-37. 2007
    ..Both effects may underline various signaling pathways which are important for cell proliferation, differentiation and function...
  5. ncbi request reprint H2O2-induced changes in mitochondrial activity in isolated mouse pancreatic acinar cells
    Antonio Gonzalez
    Department of Physiology, Faculty of Veterinary Sciences, University of Extremadura, Caceres, Spain
    Mol Cell Biochem 269:165-73. 2005
    ..This in turn could represent the mechanism of action of ROS to induce cellular damage leading to cell dysfunction and generation of pathologies in the pancreas...
  6. doi request reprint Ethanol impairs calcium homeostasis following CCK-8 stimulation in mouse pancreatic acinar cells
    Antonio Gonzalez
    Department of Physiology, Cell Physiology Research Group, Faculty of Veterinary Sciences, University of Extremadura, Avenida Universidad s n, PO Box 643, Caceres, Spain
    Alcohol 42:565-73. 2008
    ..The actions of ethanol on CCK-8 stimulation of cells create a situation potentially leading to Ca2+ overload, which is a common pathological precursor that mediates pancreatitis...
  7. ncbi request reprint Changes in mitochondrial activity evoked by cholecystokinin in isolated mouse pancreatic acinar cells
    Antonio Gonzalez
    Faculty of Veterinary Sciences, Department of Physiology, University of Extremadura, Avenida Universidad s n E 10071, Caceres, Spain
    Cell Signal 15:1039-48. 2003
    ....
  8. doi request reprint Melatonin reduces pancreatic tumor cell viability by altering mitochondrial physiology
    Antonio Gonzalez
    Department of Physiology, Cell Physiology Research Group, University of Extremadura, Caceres, Spain
    J Pineal Res 50:250-60. 2011
    ..Collectively, these data support the likelihood that melatonin reduces viability of tumor AR42J cells via its action on mitochondrial activity and caspase-3 activation...
  9. ncbi request reprint XOD-catalyzed ROS generation mobilizes calcium from intracellular stores in mouse pancreatic acinar cells
    Antonio Gonzalez
    Department of Physiology, Faculty of Veterinary Sciences, University of Extremadura, P O Box 643 10071, Caceres, Spain
    Cell Signal 14:153-9. 2002
    ..Under oxidative stress conditions, the increase in [Ca(2+)](i) could be one mechanism contributing to an overstimulation of the cell which could result in cell dysfunction and cell damage...
  10. ncbi request reprint H2O2 mobilizes Ca2+ from agonist- and thapsigargin-sensitive and insensitive intracellular stores and stimulates glutamate secretion in rat hippocampal astrocytes
    Antonio Gonzalez
    Department of Physiology, University of Extremadura, Avenida Universidad s n, E 10071 Cáceres, Spain
    Neurochem Res 31:741-50. 2006
    ....
  11. ncbi request reprint Dose-dependent effect of hydrogen peroxide on calcium mobilization in mouse pancreatic acinar cells
    María P Granados
    Department of Physiology, Faculty of Veterinary Sc, University of Extremadura, Caceres, Spain
    Biochem Cell Biol 84:39-48. 2006
    ..The action of H2O2 is mediated by oxidation of sulphydryl groups of calcium ATPases independently of IP3 generation...
  12. pmc Ethanol exerts dual effects on calcium homeostasis in CCK-8-stimulated mouse pancreatic acinar cells
    Marcela Fernández-Sánchez
    Department of Physiology, Cell Physiology Research Group, University of Extremadura, Caceres, Spain
    BMC Cell Biol 10:77. 2009
    ..Changes in [Ca2+]i and ROS production were analyzed employing fluorescence techniques after loading cells with fura-2 or CM-H2DCFDA, respectively...
  13. ncbi request reprint Ethanol induces glutamate secretion by Ca2+ mobilization and ROS generation in rat hippocampal astrocytes
    Miguel Salazar
    Department of Physiology Cell Physiology Research Group, University of Extremadura, Avenida Universidad s n, E 10071, Caceres, Spain
    Neurochem Int 52:1061-7. 2008
    ....
  14. ncbi request reprint Effect of H2O2 on CCK-8-evoked changes in mitochondrial activity in isolated mouse pancreatic acinar cells
    María P Granados
    Department of Physiology, Faculty of Veterinary Sciences, University of Extremadura, Avenida Universidad s n, E 10071, Caceres, Spain
    Biol Cell 97:847-56. 2005
    ..Cytosolic ([Ca(2+)](c)) and mitochondrial ([Ca(2+)](m)) free-calcium concentrations, mitochondrial inner membrane potential (psi(m)) and FAD autofluorescence were monitored using confocal laser scanning microscopy...
  15. ncbi request reprint Dietary virgin olive oil enhances secretagogue-evoked calcium signaling in rat pancreatic acinar cells
    Maria A Martinez
    Institute of Nutrition and Food Technology, Department of Physiology, University of Granada, Granada, Spain
    Nutrition 20:536-41. 2004
    ..Olive oil is a major component of the Mediterranean diet, and its role in human health is actively being debated...
  16. doi request reprint Ebselen increases cytosolic free Ca2+ concentration, stimulates glutamate release and increases GFAP content in rat hippocampal astrocytes
    Miguel Salazar
    Department of Physiology Cell Physiology Research Group, University of Extremadura, Avenida Universidad s n, E 10071 Cáceres, Spain
    Toxicology 244:280-91. 2008
    ..Therefore, we consider that careful attention should be paid when employing ebselen as a prophylactic agent against brain damage...
  17. pmc Ebselen alters mitochondrial physiology and reduces viability of rat hippocampal astrocytes
    Patricia Santofimia-Castaño
    Cell Physiology Research Group, Department of Physiology, University of Extremadura, Caceres, Spain
    DNA Cell Biol 32:147-55. 2013
    ..These may be early effects that do not involve caspase-3 activation. We conclude that, depending on the concentration used, ebselen might exert deleterious actions on astrocyte physiology that could compromise cell function...
  18. doi request reprint Resveratrol mobilizes Ca2+ from intracellular stores and induces c-Jun N-terminal kinase activation in tumoral AR42J cells
    Lourdes García-Sanchez
    Department of Physiology, University of Extremadura, Caceres, Spain
    Mol Cell Biochem 362:15-23. 2012
    ..Reorganization of cell's survival/death processes in the presence of resveratrol may involve Ca(2+)-mediated JNK activation...
  19. ncbi request reprint Effects of reactive oxygen species on actin filament polymerisation and amylase secretion in mouse pancreatic acinar cells
    Juan A Rosado
    Department of Physiology, Faculty of Veterinary Sciences, University of Extremadura, Caceres 10071, Spain
    Cell Signal 14:547-56. 2002
    ..The regulation of the actin cytoskeleton by ROS might be involved in radical-induced cell injury in pancreatic acinar cells...
  20. pmc Increased calcium influx in the presence of ethanol in mouse pancreatic acinar cells
    Angel del Castillo-Vaquero
    Department of Physiology Cell Physiology Research Group, University of Extremadura, Caceres, Spain
    Int J Exp Pathol 91:114-24. 2010
    ..Potentially ethanol might lead to Ca(2+) overload, which is a common pathological precursor that is implicated in pancreatitis...
  21. doi request reprint Melatonin induces calcium release from CCK-8- and thapsigargin-sensitive cytosolic stores in pancreatic AR42J cells
    Angel del Castillo-Vaquero
    Department of Physiology Cell Physiology Research Group, University of Extremadura, Caceres, Spain
    J Pineal Res 49:256-63. 2010
    ..The source for Ca(2+) mobilization most probably is the endoplasmic reticulum. These data raise the possibility that melatonin also involves Ca(2+) signalling, in addition to other intracellular messengers, to modulate cellular function...
  22. doi request reprint Ethanol reduces kainate-evoked glutamate secretion in rat hippocampal astrocytes
    Patricia Santofimia-Castaño
    Department of Physiology Cell Physiology Research Group, University of Extremadura, Caceres, Spain
    Brain Res 1402:1-8. 2011
    ....
  23. ncbi request reprint Involvement of ryanodine-operated channels in tert-butylhydroperoxide-evoked Ca2+ mobilisation in pancreatic acinar cells
    Maria A Martinez-Burgos
    Institute of Nutrition and Food Technology, Department of Physiology, University of Granada, C Ramon y Cajal, 4 18071, Granada, Spain
    J Exp Biol 209:2156-64. 2006
    ..These findings indicate that tBHP releases Ca2+ from non-mitochondrial Ca2+ pools through ryanodine channels...
  24. pmc Evidence for secretion-like coupling involving pp60src in the activation and maintenance of store-mediated Ca2+ entry in mouse pancreatic acinar cells
    Pedro C Redondo
    Department of Physiology, Faculty of Veterinary Sciences, Av Universidad s n, University of Extremadura, 10071 Caceres, Spain
    Biochem J 370:255-63. 2003
    ..pp60(src) activation requires the integrity of the actin cytoskeleton and participates in the initial phase of the activation of SMCE in pancreatic acinar cells...
  25. doi request reprint Ethanol alters the physiology of neuron-glia communication
    Antonio Gonzalez
    Department of Physiology Cell Physiology Research Group, University of Extremadura, 10071, Caceres, Spain
    Int Rev Neurobiol 88:167-98. 2009
    ..In this review we will pay attention on to the recent findings in astrocyte function and their role toward neurons under ethanol consumption...
  26. ncbi request reprint Determination of fluoxetine and norfluoxetine in human plasma by high-performance liquid chromatography with ultraviolet detection in psychiatric patients
    Adrian Llerena
    Department of Pharmacology, Faculty of Medicine, University of Extremadura, Merida, Spain
    J Chromatogr B Analyt Technol Biomed Life Sci 783:25-31. 2003
    ..Therapeutic drug monitoring should thus be useful in patients treated with regular doses...
  27. doi request reprint Oxidation of chlorfenvinphos in ultrapure and natural waters by ozonation and photochemical processes
    Juan L Acero
    Departamento de Ingeniería Química y Química Física, Universidad de Extremadura, 06071 Badajoz, Spain
    Water Res 42:3198-206. 2008
    ..A kinetic model was proposed for the prediction of the elimination rate of chlorfenvinphos in the ozonation process and the results obtained reveal a good agreement between experimental results and predicted values...
  28. pmc Ethanol consumption as inductor of pancreatitis
    Jose A Tapia
    José A Tapia, Ginés M Salido, Antonio Gonzalez, PhD, Department of Physiology, Faculty of Veterinary Sciences, University of Extremadura, Avenida Universidad s n, Cáceres E 10071, Spain
    World J Gastrointest Pharmacol Ther 1:3-8. 2010
    ..This current work will review some recent advances in the knowledge about ethanol actions on the exocrine pancreas and its relationship to inflammatory disease and cancer...