Research Topics
Genomes and GenesSpecies | M A Gonzalez-MolesSummaryAffiliation: University of Granada Country: Spain Publications
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Publications
P53 protein expression in oral squamous cell carcinoma. survival analysisM A Gonzalez-Moles
Department of Oral Medicine, School of Dentistry, University of Granada, Spain
Anticancer Res 21:2889-94. 2001..0001), clinical stage (p<0.0001), differentiation degree (p<0.01) and nucleargrade (p<0.01). CONCLUSION: The expression of p53 protein did not behave as a marker of prognostic value in patients with OSCC...
E-cadherin in non-tumor epithelium adjacent to oral cancer as risk marker for the development of multiple tumorsM A Gonzalez-Moles
Oral Medicine Department, School of Dentistry, University of Granada, Paseo de Cartuja s n, 18071 Granada, Spain
Br J Oral Maxillofac Surg 51:157-63. 2013..041, p<0.001, p=0.005) non-tumour epithelia, respectively. Downregulation of E-cadherin may be valuable as a risk marker for the development of multiple tumours in the oral cavity and for the diagnosis of premalignant fields...- Adhesion molecule CD44 expression in non-tumor epithelium adjacent to laryngeal cancerMiguel Angel Gonzalez-Moles
Department of Oral Medicine, School of Dentistry, University of Granada, Spain
Onkologie 29:9-13. 2006..Studies of adjacent non-tumor epithelia (ANTE) of laryngeal cancer have presented contradictory results regarding the expression of the adhesion molecule CD44 and its role as an early event and risk marker for progression to cancer... - Cell cycle regulating mechanisms in oral lichen planus: molecular bases in epithelium predisposed to malignant transformationM A Gonzalez-Moles
School of Dentistry, Granada University, Paseo de Cartuja s n, 18071 Granada, Spain
Arch Oral Biol 51:1093-103. 2006..Expression of p53, p21, ki-67, Bcl-2 and caspase-3 proteins in oral lichen planus (OLP) was studied to investigate cell cycle regulation mechanisms in this disease... - Prognostic significance of p21WAF1/CIP1, p16INK4a and CD44s in tongue cancerM A Gonzalez-Moles
Department of Oral Medicine, School of Dentistry, Granda University, Granada, Spain
Oncol Rep 18:389-96. 2007..002, hazards ratio: 0.028). In conclusion, low expression of CD44s is related to tumour cell invasiveness and may be of clinical relevance as a prognostic factor... - Differences in the expression of p53 protein in oral lichen planus based on the use of monoclonal antibodies DO7 and pAb 240M A Gonzalez-Moles
Oral Medicine, Dental School, Granada University, Spain
Oral Oncol 44:496-503. 2008.... - Oral lichen planus: controversies surrounding malignant transformationM A Gonzalez-Moles
Oral Medicine Department, Faculty of Dentistry, University of Granada, Granada, Spain
Oral Dis 14:229-43. 2008..The present review outlines these debates and proposes a possible a molecular basis for the malignant transformation in this disease... - Cell proliferation associated with actions of the substance P/NK-1 receptor complex in keratocystic odontogenic tumoursM A Gonzalez Moles
Department of Oral Medicine, Facultad de Odontologia, Paseo de Cartuja s n, Dental School, Granada University, 18071 Granada, Spain
Oral Oncol 44:1127-33. 2008..This pathway may be of special relevance in the multiple KOTs associated with NBCCS... - A role for the substance P/NK-1 receptor complex in cell proliferation and apoptosis in oral lichen planusM A Gonzalez Moles
Granada School of Dentistry, Oral Medicine, Granada University, Granada, Spain
Oral Dis 15:162-9. 2009..To determine whether substance P (SP) and NK-1 receptor (NK-1R) are expressed in oral lichen planus (OLP) and are related to cell proliferation and apoptosis in this disease... - Ki-67 expression in non-tumour epithelium adjacent to oral cancer as risk marker for multiple oral tumoursM A Gonzalez-Moles
Oral Medicine Department, School of Dentistry, University of Granada, Granada, Spain
Oral Dis 16:68-75. 2010..The aim of this study was to determine whether the differential assessment of epithelial proliferation is useful to diagnose premalignant fields and assess the risk of multiple tumours... - Substance P and NK-1R expression in oral precancerous epitheliumMiguel A Gonzalez-Moles
Oral Medicine Department, School of Dentistry, University of Granada, Paseo de Cartuja s n, Granada, Spain
Oncol Rep 22:1325-31. 2009..001) associated with its expression in the corresponding tumor. These findings suggest that substance P plays a role in early oral carcinogenesis by promoting the proliferation and growth of premalignant fields... - HPA-suppressive effects of aqueous clobetasol propionate in the treatment of patients with oral lichen planusM A Gonzalez-Moles
Oral Medicine Department, School of Dentistry, Granada University, Granada, Spain
J Eur Acad Dermatol Venereol 24:1055-9. 2010..Oral topical corticosteroids have potential to produce inhibition of the hypothalamus-pituitary-adrenal (HPA) axis... - Analysis of Ki-67 expression in oral squamous cell carcinoma: why Ki-67 is not a prognostic indicatorM A Gonzalez-Moles
Oral Medicine Department, School of Dentistry, University of Granada, Paseo de Cartuja s n, 18071 Granada, Spain
Oral Oncol 46:525-30. 2010..To analyze the prognostic value of Ki-67 in oral cancer and its relationship with Ki-67 expression in precancerous epithelium... - The use of topical corticoids in oral pathologyMiguel Angel Gonzalez-Moles
Department of Stomatology, School of Dentistry, Campus de Cartuja sn, 18071 Granada, Spain
Med Oral Patol Oral Cir Bucal 15:e827-31. 2010..We also analyze the correctable causes of treatment failure and the possible adverse effects that may occur after applying these drugs. All of this is achieved by conducting a critical review of these concepts... - Molecular findings in oral premalignant fields: update on their diagnostic and clinical implicationsM A Gonzalez-Moles
Oral Medicine Department, School of Dentistry, University of Granada, Granada, Spain
Oral Dis 18:40-7. 2012..This article reviews current knowledge on molecular findings in premalignant fields in the oral cavity and oropharynx and provides an update on criteria for their identification, discussing the clinical and therapeutic implications... - Analysis of p53 protein by PAb240, Ki-67 expression and human papillomavirus DNA detection in different types of odontogenic keratocystMiguel A Gonzalez-Moles
Oral Medicine, Department of Stomatology, University of Granada, Granada, Spain
Anticancer Res 26:175-81. 2006.... - Treatment of severe erosive gingival lesions by topical application of clobetasol propionate in custom traysMiguel Angel Gonzalez-Moles
University of Granada, Jaen General Hospital, and University Complutense of Madrid, Spain
Oral Surg Oral Med Oral Pathol Oral Radiol Endod 95:688-92. 2003..We sought to describe the response of patients with severe erosive gingival lesions to treatment with clobetasol propionate in Orabase paste administered in trays. The adverse effects were also recorded... - Adhesion molecule CD44 as a prognostic factor in tongue cancerMiguel Angel Gonzalez-Moles
Department of Oral Medicine, University of Granada, Spain
Anticancer Res 23:5197-202. 2003..Loss of expression of CD44 has been shown to be a factor of poor prognosis in some types of tumors. The purpose of this study was to analyze this in relation to the survival of patients with tongue cancer... - Epstein-Barr virus latent membrane protein-1 (LMP-1) expression in oral squamous cell carcinomaM A Gonzalez-Moles
Department of Oral Medicine, School of Dentistry, University of Granada, Spain
Laryngoscope 112:482-7. 2002..The present study aimed to determine the presence of EBV in oral squamous cell carcinomas (OSCCs) and the expression of LMP-1 in neoplastic cells of EBV-positive OSCCs... - Significance of p53 expression in non-tumoral epithelium adjacent to oral squamous cell carcinomasMiguel Angel Gonzalez-Moles
Department of Oral Medicine, School of Dentistry, University of Granada, Spain
J Laryngol Otol 116:355-8. 2002..The expression of p53 is an early event in oral tumorigenesis but it does not behave as an objective marker of the presence or severity of epithelial dysplasia... - p16 Expression in squamous carcinomas of the tongueM A Gonzáles-Moles
Department of Oral Medicine, School of Dentistry, University of Granada, Spain
Onkologie 25:433-6. 2002..the proportion of carcinomas with altered p16 expression; 2). whether loss of p16 is an early carcinogenic event; 3). whether p16 expression alterations influence the prognosis... - P21WAF1/CIP1 protein and tongue cancer prognosisM A Gonzalez-Moles
Department of Oral Medicine, School of Dentistry, University of Granada, Spain
Anticancer Res 24:3225-31. 2004..Neither the absence nor the degree of p21waf1/cip1 expression influenced the survival of patients in the present series. P21waf1/cip1 system alteration may be an early and frequent event in tongue carcinogenesis... - Bacterial infections of pulp and periodontal originMiguel Angel Gonzalez-Moles
Facultad de Odontologia, Universidad de Granada, Granada
Med Oral Patol Oral Cir Bucal 9:34-6; 32-4. 2004..X-rays do not provide a lot of information, but may attest to a widening of the apical space. This pathology may disseminate to surrounding tissues, leading to conditions of considerable severity... - Treatment of severe chronic oral erosive lesions with clobetasol propionate in aqueous solutionMiguel Angel Gonzalez-Moles
Department of Oral Medicine, School of Dentistry, University of Granada, Spain
Oral Surg Oral Med Oral Pathol Oral Radiol Endod 93:264-70. 2002..We sought to analyze the results of topical treatment with a mouthwash of 0.05% clobetasol in aqueous solution in 30 patients with severe oral erosive lesions... - Vesiculo-erosive oral mucosal disease--management with topical corticosteroids: (1) Fundamental principles and specific agents availableM A Gonzalez-Moles
Departamento de Medicina Oral, Facultad de Odontologia, Universidad de Granada, Campus de Cartuja sn, 18071, Granada, Spain
J Dent Res 84:294-301. 2005..The issues covered include the indications and basic rules for their use, the types of corticosteroids, the drug selection, and the specific formulations... - Vesiculo-erosive oral mucosal disease--management with topical corticosteroids: (2) Protocols, monitoring of effects and adverse reactions, and the futureM A Gonzalez-Moles
Professor of Oral Medicine, Departamento de Medicina Oral, School of Dentistry, Facultad de Odontologia, Universidad de Granada, Campus de Cartuja sn, 18071, Granada, Spain
J Dent Res 84:302-8. 2005..In this review, we outline the most widely used protocols, the most common reasons for treatment failure, and the adverse effects documented in the literature... - Adhesion molecule CD44 expression in non-tumour epithelium adjacent to tongue cancerMiguel Angel Gonzalez-Moles
Department of Oral Medicine, University of Granada, Granada, Spain
Oral Oncol 40:281-6. 2004..013). Therefore, loss of CD44 expression in ANTE can be considered an early event in lingual carcinogenesis and a marker of major alterations of CD44 expression in the derived tumour tissue... - No differences in caspase-3 and Bax expression in atrophic-erosive vs. reticular oral lichen planusC Bascones-Ilundain
School of Dentistry, University of Granada, Granada, Spain
J Eur Acad Dermatol Venereol 22:204-12. 2008..The malignant transformation of OLP remains a very controversial matter. The objective of this study was to compare histological and apoptotic phenomena between atrophic-erosive and reticular forms of OLP... - Apoptosis and cell cycle arrest in oral lichen planus Hypothesis on their possible influence on its malignant transformationC Bascones
Departamento de Estomatologia, Facultad de Odontologia, Universidad de Madrid, Complutense University, Madrid, Spain
Arch Oral Biol 50:873-81. 2005..Epithelial cells attacked in OLP have a very low response to apoptosis and cell cycle arrest mechanisms, which may produce an epithelial substrate that favours malignant transformation... - Oral ulcers: clinical aspects. A tool for dermatologists. Part I. Acute ulcersM Muñoz-Corcuera
Stomatology Department, Dental School, Complutense University of Madrid, Spain
Clin Exp Dermatol 34:289-94. 2009..The correct differential diagnosis is necessary to establish the appropriate treatment, taking into account all the possible causes of ulcers in the oral cavity. In the first part of this two-part review, acute oral ulcers are reviewed... - Methylation in oral cancer and pre-cancerous lesions (Review)R Díez-Pérez
School of Dentistry, Department of Medicine and Buccofacial Surgery, UCM, Madrid, Spain
Oncol Rep 25:1203-9. 2011..The most frequently and extensively studied methylated genes in oral premalignant lesions are p16, MGMT, RARβ2, E-cadherin and DAP-kinase... - Vigabatrin-induced modification of Ki-67 expression in gingival epithelium: immunohistochemical study of a short seriesF Mesa
Department of Periodontology, School of Dentistry, University of Granada, Spain
J Periodontal Res 39:66-71. 2004.... - Update on molecular pathology in oral cancer and precancerJ Campo-Trapero
Department of Buccofacial Medicine and Surgery, School of Dentistry, Complutense University of Madrid, Madrid, Spain
Anticancer Res 28:1197-205. 2008..These may lead to short- or medium term improvements in the diagnosis and prognosis of oral precancerous and cancerous lesions and to the development of novel therapeutic approaches to this disease... - Oral ulcers: clinical aspects. A tool for dermatologists. Part II. Chronic ulcersM Muñoz-Corcuera
Stomatology Department, Dental School, Complutense University of Madrid, Madrid, Spain
Clin Exp Dermatol 34:456-61. 2009..In this second part of this two-part review, chronic oral ulcers are reviewed... - Cell apoptosis and proliferation in salivary glands of Sjögren's syndromeB Busamia
Physiology Department, School of Dentistry, Cordoba National University, Cordoba, Argentina Oral Medicine Department, School of Dentistry, University of Granada, Granada, Spain Pathology Department, Complejo Hospitalario, Jaen, Spain Preventive and Public Health in Dentistry Department, School of Dentistry, University of Granada, Granada, Spain Sanatorio Allende, Cordoba, Argentina
J Oral Pathol Med 40:721-5. 2011..Furthermore, the markers used in this work are widely known and represent a lower cost than others and can be used to determine risk groups within the population of SS patients, enabling their follow-up... - Oral health-related quality of life and nutritional statusJ A Gil-Montoya
University of Granada School of Dentistry, Granada, Spain
J Public Health Dent 68:88-93. 2008..This study examines whether oral health-related quality of life (OHRQoL) is associated with malnutrition risk in the elderly... - Importance of tumour thickness measurement in prognosis of tongue cancerMiguel Angel Gonzalez-Moles
Department of Oral Medicine, School of Dentistry, University of Granada, Spain
Oral Oncol 38:394-7. 2002..05) than the rates of 58.3 and 57% for patients with tumour thickness of 4-7 mm and >7 mm, respectively. Wider studies are required to unify criteria for the measurement of this important prognostic parameter... - Pyostomatitis vegetans: dramatic clinical response to clobetasol propionate treatment in aqueous solutionM A Gonzalez-Moles
J Eur Acad Dermatol Venereol 22:252-3. 2008 - Significance of liquefaction degeneration in oral lichen planus: a study of its relationship with apoptosis and cell cycle arrest markersC Bascones Ilundain
Department of Periodontics and Dentistry, Complutense University, Madrid, Spain
Clin Exp Dermatol 32:556-63. 2007..To assess the utility of liquefaction degeneration as a marker of apoptosis in oral lichen planus (OLP)...