M A Gonzalez-Moles

Summary

Affiliation: University of Granada
Country: Spain

Publications

  1. ncbi request reprint P53 protein expression in oral squamous cell carcinoma. survival analysis
    M A Gonzalez-Moles
    Department of Oral Medicine, School of Dentistry, University of Granada, Spain
    Anticancer Res 21:2889-94. 2001
  2. doi request reprint The cancer stem cell hypothesis applied to oral carcinoma
    M A Gonzalez-Moles
    Department of Oral Medicine, Odontology Faculty, University of Granada, Spain
    Oral Oncol 49:738-46. 2013
  3. ncbi request reprint E-cadherin in non-tumor epithelium adjacent to oral cancer as risk marker for the development of multiple tumors
    M A Gonzalez-Moles
    Oral Medicine Department, School of Dentistry, University of Granada, Paseo de Cartuja s n, 18071 Granada, Spain
    Br J Oral Maxillofac Surg 51:157-63. 2013
  4. ncbi request reprint Cell cycle regulating mechanisms in oral lichen planus: molecular bases in epithelium predisposed to malignant transformation
    M A Gonzalez-Moles
    School of Dentistry, Granada University, Paseo de Cartuja s n, 18071 Granada, Spain
    Arch Oral Biol 51:1093-103. 2006
  5. ncbi request reprint Prognostic significance of p21WAF1/CIP1, p16INK4a and CD44s in tongue cancer
    M A Gonzalez-Moles
    Department of Oral Medicine, School of Dentistry, Granda University, Granada, Spain
    Oncol Rep 18:389-96. 2007
  6. ncbi request reprint Differences in the expression of p53 protein in oral lichen planus based on the use of monoclonal antibodies DO7 and pAb 240
    M A Gonzalez-Moles
    Oral Medicine, Dental School, Granada University, Spain
    Oral Oncol 44:496-503. 2008
  7. doi request reprint Molecular findings in oral premalignant fields: update on their diagnostic and clinical implications
    M A Gonzalez-Moles
    Oral Medicine Department, School of Dentistry, University of Granada, Granada, Spain
    Oral Dis 18:40-7. 2012
  8. doi request reprint Oral lichen planus: controversies surrounding malignant transformation
    M A Gonzalez-Moles
    Oral Medicine Department, Faculty of Dentistry, University of Granada, Granada, Spain
    Oral Dis 14:229-43. 2008
  9. doi request reprint Cell proliferation associated with actions of the substance P/NK-1 receptor complex in keratocystic odontogenic tumours
    M A Gonzalez Moles
    Department of Oral Medicine, Facultad de Odontologia, Paseo de Cartuja s n, Dental School, Granada University, 18071 Granada, Spain
    Oral Oncol 44:1127-33. 2008
  10. doi request reprint A role for the substance P/NK-1 receptor complex in cell proliferation and apoptosis in oral lichen planus
    M A Gonzalez Moles
    Granada School of Dentistry, Oral Medicine, Granada University, Granada, Spain
    Oral Dis 15:162-9. 2009

Collaborators

Detail Information

Publications43

  1. ncbi request reprint P53 protein expression in oral squamous cell carcinoma. survival analysis
    M A Gonzalez-Moles
    Department of Oral Medicine, School of Dentistry, University of Granada, Spain
    Anticancer Res 21:2889-94. 2001
    ..0001), clinical stage (p<0.0001), differentiation degree (p<0.01) and nucleargrade (p<0.01). CONCLUSION: The expression of p53 protein did not behave as a marker of prognostic value in patients with OSCC...
  2. doi request reprint The cancer stem cell hypothesis applied to oral carcinoma
    M A Gonzalez-Moles
    Department of Oral Medicine, Odontology Faculty, University of Granada, Spain
    Oral Oncol 49:738-46. 2013
    ..We review current knowledge on stem cells in relation to oral cancer, including their possible origins, focusing on the CSC hypothesis of oral tumorigenesis and attempts being made to identify oral stem cells. ..
  3. ncbi request reprint E-cadherin in non-tumor epithelium adjacent to oral cancer as risk marker for the development of multiple tumors
    M A Gonzalez-Moles
    Oral Medicine Department, School of Dentistry, University of Granada, Paseo de Cartuja s n, 18071 Granada, Spain
    Br J Oral Maxillofac Surg 51:157-63. 2013
    ..041, p<0.001, p=0.005) non-tumour epithelia, respectively. Downregulation of E-cadherin may be valuable as a risk marker for the development of multiple tumours in the oral cavity and for the diagnosis of premalignant fields...
  4. ncbi request reprint Cell cycle regulating mechanisms in oral lichen planus: molecular bases in epithelium predisposed to malignant transformation
    M A Gonzalez-Moles
    School of Dentistry, Granada University, Paseo de Cartuja s n, 18071 Granada, Spain
    Arch Oral Biol 51:1093-103. 2006
    ..Expression of p53, p21, ki-67, Bcl-2 and caspase-3 proteins in oral lichen planus (OLP) was studied to investigate cell cycle regulation mechanisms in this disease...
  5. ncbi request reprint Prognostic significance of p21WAF1/CIP1, p16INK4a and CD44s in tongue cancer
    M A Gonzalez-Moles
    Department of Oral Medicine, School of Dentistry, Granda University, Granada, Spain
    Oncol Rep 18:389-96. 2007
    ..002, hazards ratio: 0.028). In conclusion, low expression of CD44s is related to tumour cell invasiveness and may be of clinical relevance as a prognostic factor...
  6. ncbi request reprint Differences in the expression of p53 protein in oral lichen planus based on the use of monoclonal antibodies DO7 and pAb 240
    M A Gonzalez-Moles
    Oral Medicine, Dental School, Granada University, Spain
    Oral Oncol 44:496-503. 2008
    ....
  7. doi request reprint Molecular findings in oral premalignant fields: update on their diagnostic and clinical implications
    M A Gonzalez-Moles
    Oral Medicine Department, School of Dentistry, University of Granada, Granada, Spain
    Oral Dis 18:40-7. 2012
    ..This article reviews current knowledge on molecular findings in premalignant fields in the oral cavity and oropharynx and provides an update on criteria for their identification, discussing the clinical and therapeutic implications...
  8. doi request reprint Oral lichen planus: controversies surrounding malignant transformation
    M A Gonzalez-Moles
    Oral Medicine Department, Faculty of Dentistry, University of Granada, Granada, Spain
    Oral Dis 14:229-43. 2008
    ..The present review outlines these debates and proposes a possible a molecular basis for the malignant transformation in this disease...
  9. doi request reprint Cell proliferation associated with actions of the substance P/NK-1 receptor complex in keratocystic odontogenic tumours
    M A Gonzalez Moles
    Department of Oral Medicine, Facultad de Odontologia, Paseo de Cartuja s n, Dental School, Granada University, 18071 Granada, Spain
    Oral Oncol 44:1127-33. 2008
    ..This pathway may be of special relevance in the multiple KOTs associated with NBCCS...
  10. doi request reprint A role for the substance P/NK-1 receptor complex in cell proliferation and apoptosis in oral lichen planus
    M A Gonzalez Moles
    Granada School of Dentistry, Oral Medicine, Granada University, Granada, Spain
    Oral Dis 15:162-9. 2009
    ..To determine whether substance P (SP) and NK-1 receptor (NK-1R) are expressed in oral lichen planus (OLP) and are related to cell proliferation and apoptosis in this disease...
  11. doi request reprint Ki-67 expression in non-tumour epithelium adjacent to oral cancer as risk marker for multiple oral tumours
    M A Gonzalez-Moles
    Oral Medicine Department, School of Dentistry, University of Granada, Granada, Spain
    Oral Dis 16:68-75. 2010
    ..The aim of this study was to determine whether the differential assessment of epithelial proliferation is useful to diagnose premalignant fields and assess the risk of multiple tumours...
  12. ncbi request reprint Substance P and NK-1R expression in oral precancerous epithelium
    Miguel A Gonzalez-Moles
    Oral Medicine Department, School of Dentistry, University of Granada, Paseo de Cartuja s n, Granada, Spain
    Oncol Rep 22:1325-31. 2009
    ..001) associated with its expression in the corresponding tumor. These findings suggest that substance P plays a role in early oral carcinogenesis by promoting the proliferation and growth of premalignant fields...
  13. doi request reprint HPA-suppressive effects of aqueous clobetasol propionate in the treatment of patients with oral lichen planus
    M A Gonzalez-Moles
    Oral Medicine Department, School of Dentistry, Granada University, Granada, Spain
    J Eur Acad Dermatol Venereol 24:1055-9. 2010
    ..Oral topical corticosteroids have potential to produce inhibition of the hypothalamus-pituitary-adrenal (HPA) axis...
  14. ncbi request reprint Analysis of Ki-67 expression in oral squamous cell carcinoma: why Ki-67 is not a prognostic indicator
    M A Gonzalez-Moles
    Oral Medicine Department, School of Dentistry, University of Granada, Paseo de Cartuja s n, 18071 Granada, Spain
    Oral Oncol 46:525-30. 2010
    ..To analyze the prognostic value of Ki-67 in oral cancer and its relationship with Ki-67 expression in precancerous epithelium...
  15. ncbi request reprint The use of topical corticoids in oral pathology
    Miguel Angel Gonzalez-Moles
    Department of Stomatology, School of Dentistry, Campus de Cartuja sn, 18071 Granada, Spain
    Med Oral Patol Oral Cir Bucal 15:e827-31. 2010
    ..We also analyze the correctable causes of treatment failure and the possible adverse effects that may occur after applying these drugs. All of this is achieved by conducting a critical review of these concepts...
  16. ncbi request reprint Adhesion molecule CD44 expression in non-tumor epithelium adjacent to laryngeal cancer
    Miguel Angel Gonzalez-Moles
    Department of Oral Medicine, School of Dentistry, University of Granada, Spain
    Onkologie 29:9-13. 2006
    ..Studies of adjacent non-tumor epithelia (ANTE) of laryngeal cancer have presented contradictory results regarding the expression of the adhesion molecule CD44 and its role as an early event and risk marker for progression to cancer...
  17. ncbi request reprint Analysis of p53 protein by PAb240, Ki-67 expression and human papillomavirus DNA detection in different types of odontogenic keratocyst
    Miguel A Gonzalez-Moles
    Oral Medicine, Department of Stomatology, University of Granada, Granada, Spain
    Anticancer Res 26:175-81. 2006
    ....
  18. ncbi request reprint Epstein-Barr virus latent membrane protein-1 (LMP-1) expression in oral squamous cell carcinoma
    M A Gonzalez-Moles
    Department of Oral Medicine, School of Dentistry, University of Granada, Spain
    Laryngoscope 112:482-7. 2002
    ..The present study aimed to determine the presence of EBV in oral squamous cell carcinomas (OSCCs) and the expression of LMP-1 in neoplastic cells of EBV-positive OSCCs...
  19. ncbi request reprint p16 Expression in squamous carcinomas of the tongue
    M A Gonzáles-Moles
    Department of Oral Medicine, School of Dentistry, University of Granada, Spain
    Onkologie 25:433-6. 2002
    ..the proportion of carcinomas with altered p16 expression; 2). whether loss of p16 is an early carcinogenic event; 3). whether p16 expression alterations influence the prognosis...
  20. ncbi request reprint Treatment of severe erosive gingival lesions by topical application of clobetasol propionate in custom trays
    Miguel Angel Gonzalez-Moles
    University of Granada, Jaen General Hospital, and University Complutense of Madrid, Spain
    Oral Surg Oral Med Oral Pathol Oral Radiol Endod 95:688-92. 2003
    ..We sought to describe the response of patients with severe erosive gingival lesions to treatment with clobetasol propionate in Orabase paste administered in trays. The adverse effects were also recorded...
  21. ncbi request reprint Significance of p53 expression in non-tumoral epithelium adjacent to oral squamous cell carcinomas
    Miguel Angel Gonzalez-Moles
    Department of Oral Medicine, School of Dentistry, University of Granada, Spain
    J Laryngol Otol 116:355-8. 2002
    ..The expression of p53 is an early event in oral tumorigenesis but it does not behave as an objective marker of the presence or severity of epithelial dysplasia...
  22. ncbi request reprint Adhesion molecule CD44 expression in non-tumour epithelium adjacent to tongue cancer
    Miguel Angel Gonzalez-Moles
    Department of Oral Medicine, University of Granada, Granada, Spain
    Oral Oncol 40:281-6. 2004
    ..013). Therefore, loss of CD44 expression in ANTE can be considered an early event in lingual carcinogenesis and a marker of major alterations of CD44 expression in the derived tumour tissue...
  23. ncbi request reprint Adhesion molecule CD44 as a prognostic factor in tongue cancer
    Miguel Angel Gonzalez-Moles
    Department of Oral Medicine, University of Granada, Spain
    Anticancer Res 23:5197-202. 2003
    ..Loss of expression of CD44 has been shown to be a factor of poor prognosis in some types of tumors. The purpose of this study was to analyze this in relation to the survival of patients with tongue cancer...
  24. ncbi request reprint Treatment of severe chronic oral erosive lesions with clobetasol propionate in aqueous solution
    Miguel Angel Gonzalez-Moles
    Department of Oral Medicine, School of Dentistry, University of Granada, Spain
    Oral Surg Oral Med Oral Pathol Oral Radiol Endod 93:264-70. 2002
    ..We sought to analyze the results of topical treatment with a mouthwash of 0.05% clobetasol in aqueous solution in 30 patients with severe oral erosive lesions...
  25. ncbi request reprint Bacterial infections of pulp and periodontal origin
    Miguel Angel Gonzalez-Moles
    Facultad de Odontologia, Universidad de Granada, Granada
    Med Oral Patol Oral Cir Bucal 9:34-6; 32-4. 2004
    ..X-rays do not provide a lot of information, but may attest to a widening of the apical space. This pathology may disseminate to surrounding tissues, leading to conditions of considerable severity...
  26. ncbi request reprint Vesiculo-erosive oral mucosal disease--management with topical corticosteroids: (2) Protocols, monitoring of effects and adverse reactions, and the future
    M A Gonzalez-Moles
    Professor of Oral Medicine, Departamento de Medicina Oral, School of Dentistry, Facultad de Odontologia, Universidad de Granada, Campus de Cartuja sn, 18071, Granada, Spain
    J Dent Res 84:302-8. 2005
    ..In this review, we outline the most widely used protocols, the most common reasons for treatment failure, and the adverse effects documented in the literature...
  27. ncbi request reprint P21WAF1/CIP1 protein and tongue cancer prognosis
    M A Gonzalez-Moles
    Department of Oral Medicine, School of Dentistry, University of Granada, Spain
    Anticancer Res 24:3225-31. 2004
    ..Neither the absence nor the degree of p21waf1/cip1 expression influenced the survival of patients in the present series. P21waf1/cip1 system alteration may be an early and frequent event in tongue carcinogenesis...
  28. ncbi request reprint Vesiculo-erosive oral mucosal disease--management with topical corticosteroids: (1) Fundamental principles and specific agents available
    M A Gonzalez-Moles
    Departamento de Medicina Oral, Facultad de Odontologia, Universidad de Granada, Campus de Cartuja sn, 18071, Granada, Spain
    J Dent Res 84:294-301. 2005
    ..The issues covered include the indications and basic rules for their use, the types of corticosteroids, the drug selection, and the specific formulations...
  29. doi request reprint No differences in caspase-3 and Bax expression in atrophic-erosive vs. reticular oral lichen planus
    C Bascones-Ilundain
    School of Dentistry, University of Granada, Granada, Spain
    J Eur Acad Dermatol Venereol 22:204-12. 2008
    ..The malignant transformation of OLP remains a very controversial matter. The objective of this study was to compare histological and apoptotic phenomena between atrophic-erosive and reticular forms of OLP...
  30. ncbi request reprint Apoptosis and cell cycle arrest in oral lichen planus Hypothesis on their possible influence on its malignant transformation
    C Bascones
    Departamento de Estomatologia, Facultad de Odontologia, Universidad de Madrid, Complutense University, Madrid, Spain
    Arch Oral Biol 50:873-81. 2005
    ..Epithelial cells attacked in OLP have a very low response to apoptosis and cell cycle arrest mechanisms, which may produce an epithelial substrate that favours malignant transformation...
  31. doi request reprint Oral ulcers: clinical aspects. A tool for dermatologists. Part I. Acute ulcers
    M Muñoz-Corcuera
    Stomatology Department, Dental School, Complutense University of Madrid, Spain
    Clin Exp Dermatol 34:289-94. 2009
    ..The correct differential diagnosis is necessary to establish the appropriate treatment, taking into account all the possible causes of ulcers in the oral cavity. In the first part of this two-part review, acute oral ulcers are reviewed...
  32. ncbi request reprint Vigabatrin-induced modification of Ki-67 expression in gingival epithelium: immunohistochemical study of a short series
    F Mesa
    Department of Periodontology, School of Dentistry, University of Granada, Spain
    J Periodontal Res 39:66-71. 2004
    ..To study the expression and role in vigabatrin (VGB)-induced gingival enlargement of Ki-67 antigen and p27KIP1, p21WAF1, and p53, proteins that activate or inhibit cell-cycle progression...
  33. doi request reprint Methylation in oral cancer and pre-cancerous lesions (Review)
    R Díez-Pérez
    School of Dentistry, Department of Medicine and Buccofacial Surgery, UCM, Madrid, Spain
    Oncol Rep 25:1203-9. 2011
    ..The most frequently and extensively studied methylated genes in oral premalignant lesions are p16, MGMT, RARβ2, E-cadherin and DAP-kinase...
  34. doi request reprint Oral ulcers: clinical aspects. A tool for dermatologists. Part II. Chronic ulcers
    M Muñoz-Corcuera
    Stomatology Department, Dental School, Complutense University of Madrid, Madrid, Spain
    Clin Exp Dermatol 34:456-61. 2009
    ..In this second part of this two-part review, chronic oral ulcers are reviewed...
  35. ncbi request reprint Update on molecular pathology in oral cancer and precancer
    J Campo-Trapero
    Department of Buccofacial Medicine and Surgery, School of Dentistry, Complutense University of Madrid, Madrid, Spain
    Anticancer Res 28:1197-205. 2008
    ..These may lead to short- or medium term improvements in the diagnosis and prognosis of oral precancerous and cancerous lesions and to the development of novel therapeutic approaches to this disease...
  36. ncbi request reprint Cell apoptosis and proliferation in salivary glands of Sjögren's syndrome
    B Busamia
    Physiology Department, School of Dentistry, Cordoba National University, Cordoba, Argentina
    J Oral Pathol Med 40:721-5. 2011
    ....
  37. ncbi request reprint Atraumatic restorative treatment and Carisolv use for root caries in the elderly: 2-year follow-up randomized clinical trial
    J A Gil-Montoya
    School of Dentistry, Special Care in Dentistry Gerodontology Department, Granada University, Granada, Spain
    Clin Oral Investig 18:1089-95. 2014
    ..A secondary objective was to determine the factors associated with the failure of ART restorations after a 2-year follow up...
  38. pmc Evaluation of p53, caspase-3, Bcl-2, and Ki-67 markers in oral squamous cell carcinoma and premalignant epithelium in a sample from Alava Province (Spain)
    Antonio Bascones-Martinez
    Department of Medicine and Bucofacial Surgery, Dental School, Complutense University of Madrid, Plaza Ramón y Cajal 3, Ciudad Universitaria, 28040 Madrid, Spain
    Med Oral Patol Oral Cir Bucal 18:e846-50. 2013
    ..The objective of this study was to determine whether alterations in the expression of p53, caspase-3 Bcl-2, and ki-67 appear early in premalignant oral epithelium and show clonal behavior...
  39. doi request reprint Oral health-related quality of life and nutritional status
    J A Gil-Montoya
    University of Granada School of Dentistry, Granada, Spain
    J Public Health Dent 68:88-93. 2008
    ..This study examines whether oral health-related quality of life (OHRQoL) is associated with malnutrition risk in the elderly...
  40. pmc Levels of scientific evidence of the quality of life in patients treated for oral cancer
    Rocío Barrios
    School of Dentistry, University of Granada, Granada, Spain
    Med Oral Patol Oral Cir Bucal 18:e578-84. 2013
    ..Questionnaires on health-related quality of life provide concrete information regarding the impact of cancer treatment on patients. ..
  41. ncbi request reprint Importance of tumour thickness measurement in prognosis of tongue cancer
    Miguel Angel Gonzalez-Moles
    Department of Oral Medicine, School of Dentistry, University of Granada, Spain
    Oral Oncol 38:394-7. 2002
    ..05) than the rates of 58.3 and 57% for patients with tumour thickness of 4-7 mm and >7 mm, respectively. Wider studies are required to unify criteria for the measurement of this important prognostic parameter...
  42. doi request reprint Pyostomatitis vegetans: dramatic clinical response to clobetasol propionate treatment in aqueous solution
    M A Gonzalez-Moles
    J Eur Acad Dermatol Venereol 22:252-3. 2008
  43. ncbi request reprint Significance of liquefaction degeneration in oral lichen planus: a study of its relationship with apoptosis and cell cycle arrest markers
    C Bascones-Ilundain
    Department of Periodontics and Dentistry, Complutense University, Madrid, Spain
    Clin Exp Dermatol 32:556-63. 2007
    ..To assess the utility of liquefaction degeneration as a marker of apoptosis in oral lichen planus (OLP)...