Fernando Gonzalez-Candelas

Summary

Affiliation: University of Valencia
Country: Spain

Publications

  1. pmc Evidence of recombination in intrapatient populations of hepatitis C virus
    Vicente Sentandreu
    Institut Cavanilles de Biodiversitat i Biologia Evolutiva, Universitat de València València, Spain
    PLoS ONE 3:e3239. 2008
  2. pmc Genetic Characterization of Legionella pneumophila Isolated from a Common Watershed in Comunidad Valenciana, Spain
    Leonor Sánchez-Busó
    Genomics and Health Joint Unit CSISP, FISABIO University of Valencia Cavanilles Institute, Valencia, Spain
    PLoS ONE 8:e61564. 2013
  3. pmc Patient-to-patient transmission of hepatitis C virus (HCV) during colonoscopy diagnosis
    Fernando Gonzalez-Candelas
    Centre Superior d Investigació en Salut Pública CSISP, Area de Genòmica i Salut, Conselleria de Sanitat, Generalitat Valenciana, Valencia, Spain
    Virol J 7:217. 2010
  4. pmc Molecular evolution in court: analysis of a large hepatitis C virus outbreak from an evolving source
    Fernando Gonzalez-Candelas
    Joint Research Unit Genómica y Salud CSISP FISABIO, Instituto Cavanilles Universidad de Valencia, Paterna, Valencia, Spain
    BMC Biol 11:76. 2013
  5. pmc Recombination in hepatitis C virus
    Fernando Gonzalez-Candelas
    Unidad Mixta Genómica y Salud CSISP, Instituto Cavanilles de Biodiversidad y Biologia Evolutiva, Universidad de Valencia, Catedrático José Beltrán 2, E 46980 Paterna, Valencia, Spain
    Viruses 3:2006-24. 2011
  6. pmc Sociodemographic factors and clinical conditions associated to hospitalization in influenza A (H1N1) 2009 virus infected patients in Spain, 2009-2010
    Fernando Gonzalez-Candelas
    Unidad Mixta Genómica y Salud CSISP Universitat de València, Valencia, Spain
    PLoS ONE 7:e33139. 2012
  7. pmc Topology testing of phylogenies using least squares methods
    Aleksandra Czarna
    Department of Marine Genetics and Biotechnology, Institute of Oceanology, Polish Academy of Sciences, Powstancow Warszawy 55, PL 81712 Sopot, Poland
    BMC Evol Biol 6:105. 2006
  8. ncbi request reprint Genetic differentiation and structure of Hippocrepis valentina (Leguminosae) populations
    F Gonzalez-Candelas
    Institut Cavanilles de Biodiversitat i Biologia Evolutiva, Universitat de Valencia, Spain
    J Hered 91:134-41. 2000
  9. ncbi request reprint Molecular epidemiology and forensic genetics: application to a hepatitis C virus transmission event at a hemodialysis unit
    Fernando Gonzalez-Candelas
    Instituto Cavanilles de Biodiversidad y Biologia Evolutiva, Universidad de Valencia, Valencia, Spain
    J Infect Dis 187:352-8. 2003
  10. ncbi request reprint Contribution of insertions and deletions to the variability of hepatitis C virus populations
    Manuela Torres-Puente
    Instituto Cavanilles de Biodiversidad y Biología Evolutiva and Departamento de Genética, Universidad de Valencia, Spain
    J Gen Virol 88:2198-203. 2007

Collaborators

Detail Information

Publications54

  1. pmc Evidence of recombination in intrapatient populations of hepatitis C virus
    Vicente Sentandreu
    Institut Cavanilles de Biodiversitat i Biologia Evolutiva, Universitat de València València, Spain
    PLoS ONE 3:e3239. 2008
    ..From these results we conclude that recombination should be considered as a potentially relevant mechanism generating genetic variation in HCV and with important implications for the treatment of this infection...
  2. pmc Genetic Characterization of Legionella pneumophila Isolated from a Common Watershed in Comunidad Valenciana, Spain
    Leonor Sánchez-Busó
    Genomics and Health Joint Unit CSISP, FISABIO University of Valencia Cavanilles Institute, Valencia, Spain
    PLoS ONE 8:e61564. 2013
    ....
  3. pmc Patient-to-patient transmission of hepatitis C virus (HCV) during colonoscopy diagnosis
    Fernando Gonzalez-Candelas
    Centre Superior d Investigació en Salut Pública CSISP, Area de Genòmica i Salut, Conselleria de Sanitat, Generalitat Valenciana, Valencia, Spain
    Virol J 7:217. 2010
    ..In this study, a case of nosocomial transmission of HCV from a common source to two patients who underwent colonoscopy in an endoscopy unit is reported...
  4. pmc Molecular evolution in court: analysis of a large hepatitis C virus outbreak from an evolving source
    Fernando Gonzalez-Candelas
    Joint Research Unit Genómica y Salud CSISP FISABIO, Instituto Cavanilles Universidad de Valencia, Paterna, Valencia, Spain
    BMC Biol 11:76. 2013
    ..Here, we present the results of such an analysis that contributed to the conviction of an anesthetist as being responsible for the infection of 275 of his patients with hepatitis C virus...
  5. pmc Recombination in hepatitis C virus
    Fernando Gonzalez-Candelas
    Unidad Mixta Genómica y Salud CSISP, Instituto Cavanilles de Biodiversidad y Biologia Evolutiva, Universidad de Valencia, Catedrático José Beltrán 2, E 46980 Paterna, Valencia, Spain
    Viruses 3:2006-24. 2011
    ..Finally, we analyze the potential consequences, especially in clinical practice, of HCV recombination in light of the coming new therapeutic approaches against this virus...
  6. pmc Sociodemographic factors and clinical conditions associated to hospitalization in influenza A (H1N1) 2009 virus infected patients in Spain, 2009-2010
    Fernando Gonzalez-Candelas
    Unidad Mixta Genómica y Salud CSISP Universitat de València, Valencia, Spain
    PLoS ONE 7:e33139. 2012
    ..08) or for three or more (OR 4.86) risk factors were simultaneously present in the same patient. These findings should be considered when a new influenza virus appears in the human population...
  7. pmc Topology testing of phylogenies using least squares methods
    Aleksandra Czarna
    Department of Marine Genetics and Biotechnology, Institute of Oceanology, Polish Academy of Sciences, Powstancow Warszawy 55, PL 81712 Sopot, Poland
    BMC Evol Biol 6:105. 2006
    ..The weighted LS (WLS) allows for a more efficient albeit approximate calculation of the test statistic by ignoring the covariances between the distances...
  8. ncbi request reprint Genetic differentiation and structure of Hippocrepis valentina (Leguminosae) populations
    F Gonzalez-Candelas
    Institut Cavanilles de Biodiversitat i Biologia Evolutiva, Universitat de Valencia, Spain
    J Hered 91:134-41. 2000
    ..For the remaining populations, there is evidence of substantial differentiation. These results have implications for the design of a conservation strategy for this species...
  9. ncbi request reprint Molecular epidemiology and forensic genetics: application to a hepatitis C virus transmission event at a hemodialysis unit
    Fernando Gonzalez-Candelas
    Instituto Cavanilles de Biodiversidad y Biologia Evolutiva, Universidad de Valencia, Valencia, Spain
    J Infect Dis 187:352-8. 2003
    ..The method allows a statistical evaluation that the likelihood of each sample belonging or not to a given group, a question of relevance in many forensic and epidemiological analyses of molecular sequences...
  10. ncbi request reprint Contribution of insertions and deletions to the variability of hepatitis C virus populations
    Manuela Torres-Puente
    Instituto Cavanilles de Biodiversidad y Biología Evolutiva and Departamento de Genética, Universidad de Valencia, Spain
    J Gen Virol 88:2198-203. 2007
    ..Moreover, their frequency distributions between different time samples reflect the quasispecies dynamics of HCV populations. Deletions seem to be subject to negative selection...
  11. ncbi request reprint Hepatitis C virus and the controversial role of the interferon sensitivity determining region in the response to interferon treatment
    Manuela Torres-Puente
    Instituto Cavanilles de Biodiversidad y Biología Evolutiva and Departamento de Genética, Universidad de Valencia, Valencia, Spain
    J Med Virol 80:247-53. 2008
    ..More complex interactions, including the ISDR or not, are likely to exist and govern the HCV response to interferon treatment...
  12. ncbi request reprint Combined therapy of interferon plus ribavirin promotes multiple adaptive solutions in hepatitis C virus
    José M Cuevas
    Departamento de Genetica, Instituto Cavanilles de Biodiversidad y Biologia Evolutiva, Universidad de Valencia, Valencia, Spain
    J Med Virol 81:650-6. 2009
    ....
  13. ncbi request reprint Effect of antiviral treatment and host susceptibility on positive selection in hepatitis C virus (HCV)
    Nuria Jiménez-Hernández
    Instituto Cavanilles de Biodiversidad y Biologia Evolutiva, Universitat de Valencia, Spain
    Virus Res 131:224-32. 2008
    ..We conclude that the host's genetic factors play an important role in whether the disease is contained or becomes chronic...
  14. ncbi request reprint Analysis of the overdispersed clock in the short-term evolution of hepatitis C virus: Using the E1/E2 gene sequences to infer infection dates in a single source outbreak
    Borys Wrobel
    Institut Cavanilles de Biodiversitat i Biologia Evolutiva, Universitat de Valencia, Valencia, Spain
    Mol Biol Evol 23:1242-53. 2006
    ..Consequently, despite the distortion introduced by positive selection on evolutionary rates, it is possible to obtain quite accurate estimates of infection dates, a result of especial relevance for molecular epidemiology studies...
  15. ncbi request reprint Using evolutionary tools to refine the new hypervariable region 3 within the envelope 2 protein of hepatitis C virus
    Manuela Torres-Puente
    Institut Cavanilles de Biodiversitat i Biologia Evolutiva, Departament de Genetica, Universitat de Valencia, Valencia, Spain
    Infect Genet Evol 8:74-82. 2008
    ..Moreover, for the recently described HVR3, our results suggest that its location could be restricted to residues 434-450, instead of the originally postulated 431-466...
  16. pmc Genetic variability of hepatitis C virus before and after combined therapy of interferon plus ribavirin
    José Manuel Cuevas
    Instituto Cavanilles de Biodiversidad y Biología Evolutiva and Departamento de Genética, Universidad de Valencia, Valencia, Spain
    PLoS ONE 3:e3058. 2008
    ....
  17. pmc Molecular epidemiology of a hepatitis C virus outbreak in a hemodialysis unit
    Maria Alma Bracho
    Institut Cavanilles de Biodiversitat i Biologia Evolutiva, Universitat de Valencia, Valencia, Spain
    J Clin Microbiol 43:2750-5. 2005
    ..The direction of the transmissions was further corroborated by different measures of genetic variability within and among samples...
  18. pmc Molecular epidemiology and evolution in an outbreak of fulminant hepatitis B virus
    Maria Alma Bracho
    Institut Cavanilles de Biodiversitat i Biologia Evolutiva, Universitat de Valencia, Apartado 22085, 46071 Valencia, Spain
    J Clin Microbiol 44:1288-94. 2006
    ....
  19. ncbi request reprint Genetic variability in environmental isolates of Legionella pneumophila from Comunidad Valenciana (Spain)
    Mireia Coscollá
    Institut Cavanilles de Biodiversitat i Biologia Evolutiva and Departament de Genètica, Universitat de Valencia, 46071 Valencia, Spain
    Environ Microbiol 8:1056-63. 2006
    ..Furthermore, although linkage disequilibrium measures indicate a clonal nature for population structure in this sample, the presence of some recombination events cannot be ruled out...
  20. ncbi request reprint Epidemic dynamics of two coexisting hepatitis C virus subtypes
    Nuria Jiménez-Hernández
    Instituto Cavanilles de Biodiversidad y Biología Evolutiva and Departamento de Genética, Universidad de Valencia, Spain
    J Gen Virol 88:123-33. 2007
    ....
  21. ncbi request reprint Population structure and recombination in environmental isolates of Legionella pneumophila
    Mireia Coscollá
    Institut Cavanilles de Biodiversitat i Biologia Evolutiva and Departament de Genètica, Universitat de Valencia, 46071 Valencia, Spain
    Environ Microbiol 9:643-56. 2007
    ..pneumophila is much more frequent than previously considered and that it does not seem to be restricted to already described pathogenicity islands or other genome constituents which provide it with a high plasticity...
  22. ncbi request reprint A new subtype of hepatitis C virus genotype 1: complete genome and phylogenetic relationships of an Equatorial Guinea isolate
    Maria Alma Bracho
    Institut Cavanilles de Biodiversitat i Biologia Evolutiva, Universitat de Valencia, 46070 València, Spain
    J Gen Virol 87:1697-702. 2006
    ..Genetic divergence of the coding region of this new sequence with respect to the recognized subtypes of HCV-1 ranged from 20 to 22%. It is proposed that this isolate is a representative of a new, distinct variant of HCV subtype 1...
  23. pmc Effect of oligonucleotide primers in determining viral variability within hosts
    Maria Alma Bracho
    Institut Cavanilles de Biodiversitat i Biologia Evolutiva, Universitat de Valencia, Edifici Instituts, Polígon La Coma s n, Paterna, Spain
    Virol J 1:13. 2004
    ..Although bias in template-to-product ratios has been described before, its relevance in describing viral genetic variability at the intrapatient level has not been fully assessed yet...
  24. ncbi request reprint Unequal distribution of RT-PCR artifacts along the E1-E2 region of Hepatitis C virus
    Pilar Domingo-Calap
    Instituto Cavanilles de Biodiversidad y Biologia Evolutiva, Universitat de Valencia, Spain
    J Virol Methods 161:136-40. 2009
    ..The data suggest that the RNA sequence context or secondary structure can determine the fidelity of in vitro transcription or reverse transcription. Potentially, these factors might also modify the fidelity of the viral polymerase...
  25. ncbi request reprint Mapping natural polymorphisms of hepatitis C virus NS3/4A protease and antiviral resistance to inhibitors in worldwide isolates
    F Xavier López-Labrador
    Public Health Department, Generalitat Valenciana, Institut Cavanilles de Biodiversitat i Biologia Evolutiva ICBiBE, E 46071 Valencia, Spain
    Antivir Ther 13:481-94. 2008
    ..Here, we aimed to determine both the natural variability and presence of resistance or compensatory mutations to new protease inhibitors (PI) in NS3/4A proteases from worldwide HCV isolates...
  26. ncbi request reprint From phylogenetics to phylogenomics: the evolutionary relationships of insect endosymbiotic gamma-Proteobacteria as a test case
    Iñaki Comas
    Institut Cavanilles de Biodiversitat i Biologia Evolutiva, Universitat de Valencia, Valencia, Spain
    Syst Biol 56:1-16. 2007
    ..Nevertheless, other phylogenomic methods such as supertree approaches were useful in revealing alternative phylogenetic signals and should be included in comprehensive phylogenomic studies...
  27. ncbi request reprint Evolution of arginine deiminase (ADI) pathway genes
    Manuel Zúñiga
    Instituto de Agroquimica y Tecnologia de Alimentos CSIC, Valencia, Spain
    Mol Phylogenet Evol 25:429-44. 2002
    ..Furthermore, the molecular phylogenetic analysis of OTC suggests a new classification of these genes into three subfamilies...
  28. pmc Validating viral quasispecies with digital organisms: a re-examination of the critical mutation rate
    Iñaki Comas
    Institut Cavanilles de Biodiversitat i Biologia Evolutiva, Universitat de Valencia, Spain
    BMC Evol Biol 5:5. 2005
    ..These experiments revealed that under high mutation rates populations of less fit organisms previously adapted to such high mutation rates were able to outcompete organisms with higher average fitness but adapted to low mutation rates...
  29. pmc Legionellosis outbreak associated with asphalt paving machine, Spain, 2009
    Mireia Coscollá
    Universidad de Valencia Instituto Cavanilles de Biodiversidad y Biologia Evolutiva, Valencia, Spain
    Emerg Infect Dis 16:1381-7. 2010
    ..As opposed to other machines used for street cleaning, the responsible milling machine used water from a natural spring. When the operation of this machine was prohibited and cleaning measures were adopted, infections ceased...
  30. pmc Complete genome of a European hepatitis C virus subtype 1g isolate: phylogenetic and genetic analyses
    Maria A Bracho
    Institut Cavanilles de Biodiversitat i Biologia Evolutiva, Universitat de Valencia, Paterna, Valencia, Spain
    Virol J 5:72. 2008
    ..Of these, 20 correspond to confirmed subtypes of epidemic interest...
  31. pmc Phylogenetic signal and functional categories in Proteobacteria genomes
    Iñaki Comas
    Instituto Cavanilles de Biodiversidad y Biologia Evolutiva, Universidad de Valencia, Apartado Oficial 22085, Valencia E 46071, Spain
    BMC Evol Biol 7:S7. 2007
    ..In this report we have addressed the impact of factors like the universal distribution of the genes, their essentiality or their functional role in the cell on the inference of vertical signal through phylogenomic methods...
  32. ncbi request reprint Sampling and repeatability in the evaluation of hepatitis C virus genetic variability
    Manuela Torres-Puente
    Institut Cavanilles de Biodiversitat i Biologia Evolutiva and Departament de Genètica, Universitat de Valencia, Apartado Oficial 2085, 46071 Valencia, Spain
    J Gen Virol 84:2343-50. 2003
    ..These results validate the use of relatively small sample sets for the evaluation of genetic variability and for the estimation of phylogenetic relationships of RNA viruses in population and epidemiological studies...
  33. ncbi request reprint Horizontal gene transfer in the molecular evolution of mannose PTS transporters
    Manuel Zúñiga
    Instituto de Agroquimica y Tecnologia de Alimentos, IATA CSIC, 46100 Burjassot, Valencia, Spain
    Mol Biol Evol 22:1673-85. 2005
    ..The functional role and distribution of mannose-class PTS transporters suggest that their expansion may have played a significant role in the establishment of symbiotic relationships between animals and some bacteria...
  34. ncbi request reprint The role of positive selection in hepatitis C virus
    José M Cuevas
    Instituto Cavanilles de Biodiversidad y Biología Evolutiva and Departamento de Genética, Universidad de Valencia, Valencia, Spain
    Infect Genet Evol 9:860-6. 2009
    ..In this sense, the particular systemic response from each patient could play an essential role in determining the outcome of the antiviral treatment...
  35. ncbi request reprint Comparison of clinical and environmental samples of Legionella pneumophila at the nucleotide sequence level
    Mireia Coscollá
    Instituto Cavanilles de Biodiversidad y Biologia Evolutiva, Universidad de Valencia, Apartado Oficial 22085, 46071 Valencia, Spain
    Infect Genet Evol 9:882-8. 2009
    ..The comparison of each individual gene tree with the others revealed several cases of incongruence involving samples from both origins, thus suggesting the presence of recombination in the two groups...
  36. ncbi request reprint The population genetics and evolutionary epidemiology of RNA viruses
    Andres Moya
    Institut Cavanilles de Biodiversitat i Biologia Evolutiva, Universitat de Valencia, Apartado Postal 22085, 46071 Valencia, Spain
    Nat Rev Microbiol 2:279-88. 2004
  37. ncbi request reprint The evolutionary origin of Xanthomonadales genomes and the nature of the horizontal gene transfer process
    Iñaki Comas
    Instituto Cavanilles de Biodiversidad y Biologia Evolutiva, Universidad de Valencia, Valencia, Spain
    Mol Biol Evol 23:2049-57. 2006
    ....
  38. pmc Unraveling the evolutionary history of the phosphoryl-transfer chain of the phosphoenolpyruvate:phosphotransferase system through phylogenetic analyses and genome context
    Iñaki Comas
    Instituto de Agroquimica y Tecnologia de Alimentos, CSIC, Valencia, Spain
    BMC Evol Biol 8:147. 2008
    ..The aim of this work is to test this hypothesis by studying the evolution of the phosphoryl transfer proteins of the PTS...
  39. pmc The genome sequence of Blochmannia floridanus: comparative analysis of reduced genomes
    Rosario Gil
    Institut Cavanilles de Biodiversitat i Biologia Evolutiva, Universitat de Valencia, Apartat Oficial 2085, 46071 Valencia, Spain
    Proc Natl Acad Sci U S A 100:9388-93. 2003
    ..Comparative analysis of the five known genomes from insect endosymbiotic bacteria reveals they share only 313 genes, a number that may be close to the minimum gene set necessary to sustain endosymbiotic life...
  40. pmc Evolutionary history of the OmpR/IIIA family of signal transduction two component systems in Lactobacillaceae and Leuconostocaceae
    Manuel Zúñiga
    Departamento de Biotecnologia de Alimentos, Instituto de Agroquimica y Tecnologia de Alimentos, Consejo Superior de Investigaciones Cientificas, PO Box 73, 46100 Burjassot, Valencia, Spain
    BMC Evol Biol 11:34. 2011
    ..LAB colonize nutrient-rich environments such as foodstuffs, plant materials and the gastrointestinal tract of animals thus driving the study of this group of both basic and applied interest...
  41. pmc Enterovirus co-infections and onychomadesis after hand, foot, and mouth disease, Spain, 2008
    Maria A Bracho
    Centro Superior de Investigación en Salud Pública, Valencia, Spain
    Emerg Infect Dis 17:2223-31. 2011
    ....
  42. pmc Effect of ribavirin on the mutation rate and spectrum of hepatitis C virus in vivo
    José M Cuevas
    Departamento de Genetica, Institut Cavanilles de Biodiversitat i Biologia Evolutiva, Universitat de Valencia, Valencia, Spain
    J Virol 83:5760-4. 2009
    ..This result is consistent with the known in vitro mutagenic effect of ribavirin and suggests that the antiviral effect of ribavirin plus interferon treatment is at least partly exerted through lethal mutagenesis...
  43. pmc Polyphyletic origin of Vibrio vulnificus biotype 2 as revealed by sequence-based analysis
    Eva Sanjuan
    Departamento de Microbiologia, Facultad de Biologia, Universidad de Valencia, Valencia, Spain
    Appl Environ Microbiol 77:688-95. 2011
    ..These results support the reclassification of biotype 2 as a pathovar that would group the strains with pathogenic potential to develop vibriosis in fish...
  44. doi request reprint Quantifying nonvertical inheritance in the evolution of Legionella pneumophila
    Mireia Coscollá
    Unidad Mixta de Investigación Genómica y Salud CSISP UV Institut Cavanilles de Biodiversitat i Biologia Evolutiva, Valencia, Spain
    Mol Biol Evol 28:985-1001. 2011
    ..Phylogenetic proximity and increased chances resulting from sharing the ecological niche provided by the amoeba host have likely had a major influence on the rate of gene exchange in Legionella...
  45. pmc Direct sequencing of Legionella pneumophila from respiratory samples for sequence-based typing analysis
    Mireia Coscollá
    Institut Cavanilles de Biodiversitat i Biologia Evolutiva, University of Valencia, Apartado Oficial 22085, Valencia 46071, Spain
    J Clin Microbiol 47:2901-5. 2009
    ....
  46. ncbi request reprint Mixed infection by Legionella pneumophila in outbreak patients
    Mireia Coscollá
    Unidad Mixta Genómica y Salud, FISABIO Salud Pública, Universidad de Valencia, Instituto Cavanilles de Biodiversidad y Biologia Evolutiva, Valencia, Spain CIBER en Epidemiología y Salud Pública CIBERESP, Spain Tuberculosis Research Unit, Swiss Tropical and Public Health Institute, Basel, Switzerland
    Int J Med Microbiol 304:307-13. 2014
    ..None of the environmental samples analyzed during this outbreak was even similar to any of the clinical ones. ..
  47. pmc epiPATH: an information system for the storage and management of molecular epidemiology data from infectious pathogens
    Alicia Amadoz
    Institut Cavanilles de Biodiversitat i Biologia Evolutiva and Departament de Genètica, Universitat de Valencia, Spain
    BMC Infect Dis 7:32. 2007
    ....
  48. doi request reprint Onychomadesis outbreak in Valencia, Spain associated with hand, foot, and mouth disease caused by enteroviruses
    Javier López Davia
    Dermatology Service, University General Hospital Consortium, Valencia, Spain
    Pediatr Dermatol 28:1-5. 2011
    ..The 2008 onychomadesis outbreak in the metropolitan area of Valencia was associated with an outbreak of hand, foot, and mouth disease primarily caused by coxsackievirus A10...
  49. pmc The USH2A c.2299delG mutation: dating its common origin in a Southern European population
    Elena Aller
    Unidad de Genetica, Hospital Universitario La Fe, Valencia, Spain
    Eur J Hum Genet 18:788-93. 2010
    ..Our data confirm the common ancestral origin of the c.2299delG mutation...
  50. doi request reprint Evolution of snake venom disintegrins by positive Darwinian selection
    Paula Juárez
    Instituto de Biomedicina de Valencia, Consejo Superior de Investigaciones Biológicas, Valencia, Spain
    Mol Biol Evol 25:2391-407. 2008
    ..Perhaps, this represents a consequence of the neofunctionalization potential of the disintegrin domain, a feature that may underlie its recruitment into the venom proteome followed by its successful transformation into a toxin...
  51. pmc Domain organization and evolution of multifunctional autoprocessing repeats-in-toxin (MARTX) toxin in Vibrio vulnificus
    Francisco J Roig
    Departamento de Microbiologia, Facultad de Biologia, Universidad de Valencia, Valencia, Spain
    Appl Environ Microbiol 77:657-68. 2011
    ..Finally, we have found evidence that the evolutionary history of the rtxA1 gene for biotype 2 differs totally from the gene history of biotypes 1 and 3...
  52. pmc Common gene expression strategies revealed by genome-wide analysis in yeast
    José García-Martínez
    Sección de Chips de DNA SCSIE, Universitat de Valencia, Dr Moliner 50, E 46100, Burjassot, Spain
    Genome Biol 8:R222. 2007
    ..However, because mRNA is an intermediate step and the amounts of both mRNA and protein are controlled by their synthesis and degradation rates, the desired amount of protein can be achieved following different strategies...
  53. doi request reprint Ultradeep sequencing analysis of population dynamics of virus escape mutants in RNAi-mediated resistant plants
    Fernando Martinez
    Instituto de Biologia Molecular y Celular de Plantas, Consejo Superior de Investigaciones Cientificas Universidad Politecnica de Valencia, Valencia, Spain
    Mol Biol Evol 29:3297-307. 2012
    ....
  54. pmc Phylogeography and genetic variation of Triatoma dimidiata, the main Chagas disease vector in Central America, and its position within the genus Triatoma
    Maria Dolores Bargues
    Departamento de Parasitologia, Facultad de Farmacia, Universidad de Valencia, Burjassot, Valencia, Spain
    PLoS Negl Trop Dis 2:e233. 2008
    ..dimidiata and its closest relatives within Triatoma. This is the largest interpopulational analysis performed on a triatomine species so far...