Angel Gil

Summary

Affiliation: University of Granada
Country: Spain

Publications

  1. pmc The FINUT healthy lifestyles guide: Beyond the food pyramid
    Angel Gil
    Departments of Biochemistry and Molecular Biology II Iberomerican Nutrition Foundation FINUT, Granada, Spain
    Adv Nutr 5:358S-67S. 2014
  2. pmc Cell-free culture supernatant of Bifidobacterium breve CNCM I-4035 decreases pro-inflammatory cytokines in human dendritic cells challenged with Salmonella typhi through TLR activation
    Miriam Bermudez-Brito
    Department of Biochemistry and Molecular Biology II, Institute of Nutrition and Food Technology José Mataix, Biomedical Research Center, University of Granada, Granada, Spain
    PLoS ONE 8:e59370. 2013
  3. doi request reprint Third Jesús Culebras Lecture - Molecular biology and clinical nutrition; where do we stand and where do we go?
    Angel Gil
    Instituto de Nutrición y Tecnología de los Alimentos José Mataix, Centro de Investigacion Biomedica, Universidad de Granada, Avenida del Conocimiento s n, 18100 Armilla Granada España
    Nutr Hosp 28:241-9. 2013
  4. doi request reprint Alterations in plasma and tissue lipids associated with obesity and metabolic syndrome
    Concepcion M Aguilera
    Department of Biochemistry and Molecular Biology II, Institute of Nutrition and Food Technology, School of Pharmacy, University of Granada, Campus de Cartuja 18071 Granada, Spain
    Clin Sci (Lond) 114:183-93. 2008
  5. ncbi request reprint Polyunsaturated fatty acids and inflammatory diseases
    A Gil
    Departamento de Bioquimica y Biologia Molecular, Facultad de Farmacia, Universidad de Granada, Spain
    Biomed Pharmacother 56:388-96. 2002
  6. ncbi request reprint Modulation of the immune response mediated by dietary nucleotides
    A Gil
    Department of Biochemistry and Molecular Biology, University of Granada, Granada, Spain
    Eur J Clin Nutr 56:S1-4. 2002
  7. ncbi request reprint [Experimental models of cardiovascular disease]
    A Gil Hernández
    Departamento de Bioquimica y Biologia Molecular II, Instituto de Nutricion y Tecnologia de los Alimentos, Universidad de Granada, Espana
    Nutr Hosp 22:169-77. 2007
  8. ncbi request reprint Role of long-chain polyunsaturated fatty acids in infant nutrition
    A Gil
    Department of Biochemistry and Molecular Biology, School of Pharmacy, University of Granada, Granada, Spain
    Eur J Clin Nutr 57:S31-4. 2003
  9. ncbi request reprint [Bases for adequate complementary feeding in infants and young children]
    A Gil Hernández
    Departamento de Bioquimica y Biologia Molecular II, Facultad de Farmacia, Instituto de Nutricion y Tecnologia de los Alimentos, Universidad de Granada, Espana
    An Pediatr (Barc) 65:481-95. 2006
  10. ncbi request reprint Altered signalling and gene expression associated with the immune system and the inflammatory response in obesity
    Angel Gil
    Institute of Nutrition and Food Technology, Department of Biochemistry and Molecular Biology, University of Granada, Granada, Spain
    Br J Nutr 98:S121-6. 2007

Collaborators

Detail Information

Publications99

  1. pmc The FINUT healthy lifestyles guide: Beyond the food pyramid
    Angel Gil
    Departments of Biochemistry and Molecular Biology II Iberomerican Nutrition Foundation FINUT, Granada, Spain
    Adv Nutr 5:358S-67S. 2014
    ..It includes an environmental and sustainability dimension providing measures that should contribute to the prevention of noncommunicable chronic diseases...
  2. pmc Cell-free culture supernatant of Bifidobacterium breve CNCM I-4035 decreases pro-inflammatory cytokines in human dendritic cells challenged with Salmonella typhi through TLR activation
    Miriam Bermudez-Brito
    Department of Biochemistry and Molecular Biology II, Institute of Nutrition and Food Technology José Mataix, Biomedical Research Center, University of Granada, Granada, Spain
    PLoS ONE 8:e59370. 2013
    ..This supernatant may protect immune system from highly infectious agents such as Salmonella typhi and can down-regulate pro-inflammatory pathways...
  3. doi request reprint Third Jesús Culebras Lecture - Molecular biology and clinical nutrition; where do we stand and where do we go?
    Angel Gil
    Instituto de Nutrición y Tecnología de los Alimentos José Mataix, Centro de Investigacion Biomedica, Universidad de Granada, Avenida del Conocimiento s n, 18100 Armilla Granada España
    Nutr Hosp 28:241-9. 2013
    ..Further research in those areas should contribute to evaluate functionality of specific nutrients and bioactive compounds in Clinical Nutrition and allow personalized nutritional advice. ..
  4. doi request reprint Alterations in plasma and tissue lipids associated with obesity and metabolic syndrome
    Concepcion M Aguilera
    Department of Biochemistry and Molecular Biology II, Institute of Nutrition and Food Technology, School of Pharmacy, University of Granada, Campus de Cartuja 18071 Granada, Spain
    Clin Sci (Lond) 114:183-93. 2008
    ..In addition, alteration of AMPK signalling in the hypothalamus, which may function as a sensor of nutrient availability, integrating multiple nutritional and hormonal signals, may have a key role in the appearance of the MS...
  5. ncbi request reprint Polyunsaturated fatty acids and inflammatory diseases
    A Gil
    Departamento de Bioquimica y Biologia Molecular, Facultad de Farmacia, Universidad de Granada, Spain
    Biomed Pharmacother 56:388-96. 2002
    ..Moreover, the defence antioxidant system in this model is enhanced in treated animals, provided that the n-3 PUFA supply is adequately preserved from oxidation...
  6. ncbi request reprint Modulation of the immune response mediated by dietary nucleotides
    A Gil
    Department of Biochemistry and Molecular Biology, University of Granada, Granada, Spain
    Eur J Clin Nutr 56:S1-4. 2002
    ....
  7. ncbi request reprint [Experimental models of cardiovascular disease]
    A Gil Hernández
    Departamento de Bioquimica y Biologia Molecular II, Instituto de Nutricion y Tecnologia de los Alimentos, Universidad de Granada, Espana
    Nutr Hosp 22:169-77. 2007
    ..On the other hand, some of the cell lines most frequently used in studying molecular mechanisms of atherosclerosis and assessment of substances with nutritional or pharmacological interest are considered...
  8. ncbi request reprint Role of long-chain polyunsaturated fatty acids in infant nutrition
    A Gil
    Department of Biochemistry and Molecular Biology, School of Pharmacy, University of Granada, Granada, Spain
    Eur J Clin Nutr 57:S31-4. 2003
    ..Moreover, the influences of LC-PUFA sources on plasma composition as well as the effects of these fatty acids on intestinal repair after malnutrition are discussed...
  9. ncbi request reprint [Bases for adequate complementary feeding in infants and young children]
    A Gil Hernández
    Departamento de Bioquimica y Biologia Molecular II, Facultad de Farmacia, Instituto de Nutricion y Tecnologia de los Alimentos, Universidad de Granada, Espana
    An Pediatr (Barc) 65:481-95. 2006
    ..These recommendations are particularly addressed to pediatricians working in primary health services...
  10. ncbi request reprint Altered signalling and gene expression associated with the immune system and the inflammatory response in obesity
    Angel Gil
    Institute of Nutrition and Food Technology, Department of Biochemistry and Molecular Biology, University of Granada, Granada, Spain
    Br J Nutr 98:S121-6. 2007
    ..The present paper will focus on the molecular mechanisms linking obesity and inflammation with emphasis on the alteration of signalling and gene expression in adipose cell components...
  11. ncbi request reprint [Advanced glycation and lipoxidation end products--amplifiers of inflammation: the role of food]
    A Gil
    Departamento de Hepatología, Universidad de Lund, Suecia y Universidad de Londre, Gran Bretaña
    Nutr Hosp 22:625-40. 2007
    ....
  12. ncbi request reprint Exogenous nucleic acids and nucleotides are efficiently hydrolysed and taken up as nucleosides by intestinal explants from suckling piglets
    Angel Gil
    Department of Biochemistry and Molecular Biology II, School of Pharmacy, University of Granada, Campus de Cartuja, 18071 Granada, Spain
    Br J Nutr 98:285-91. 2007
    ..These results suggest that the current concentration of NT used to supplement infant formulas should be reconsidered...
  13. ncbi request reprint Sunflower oil does not protect against LDL oxidation as virgin olive oil does in patients with peripheral vascular disease
    C M Aguilera
    Department of Biochemistry and Molecular Biology, Facultad de Farmacia, Institute of Nutrition and Food Technology, University of Granada, C Ramon y Cajal, 4, 18071, Granada, Spain
    Clin Nutr 23:673-81. 2004
    ....
  14. doi request reprint Plasma inflammatory and vascular homeostasis biomarkers increase during human pregnancy but are not affected by oily fish intake
    Cruz E García-Rodríguez
    Department of Biochemistry and Molecular Biology II, Institute of Nutrition and Food Technology José Mataix, Biomedical Research Center, University of Granada, Granada, Spain
    J Nutr 142:1191-6. 2012
    ..69). The remaining biomarkers analyzed were similar in both groups. Therefore, although some inflammatory and vascular homeostasis biomarkers change during pregnancy, they are not affected by the increased intake of farmed salmon...
  15. doi request reprint Deleterious effect of human umbilical cord blood mononuclear cell transplantation on thioacetamide-induced chronic liver damage in rats
    Ana I Alvarez-Mercado
    Department of Biochemistry and Molecular Biology II, School of Pharmacy, University of Granada, Campus de Cartuja, 18071 Granada, Spain
    Cell Transplant 18:1069-79. 2009
    ..Taken together, the histological and biochemical data suggest that the cirrhotic rats subjected to HUCBM cell therapy developed a hepatorenal syndrome...
  16. ncbi request reprint Oral administration of a turmeric extract inhibits erythrocyte and liver microsome membrane oxidation in rabbits fed with an atherogenic diet
    M Dolores Mesa
    Department of Biochemistry and Molecular Biology, Granada, Spain
    Nutrition 19:800-4. 2003
    ....
  17. doi request reprint Competitive inhibition of three novel bacteria isolated from faeces of breast milk-fed infants against selected enteropathogens
    Sergio Muñoz-Quezada
    Department of Biochemistry and Molecular Biology II, Institute of Nutrition and Food Technology José Mataix, Biomedical Research Centre, University of Granada, Avenida del Conocimiento s n, 18100 Armilla, Granada, Spain
    Br J Nutr 109:S63-9. 2013
    ..paracasei CNCM I-4034, B. breve CNCM I-4035 and L. rhamnosus CNCM I-4036 produce compounds that exhibited strain-specific inhibition of enterobacteria and have the potential to be used as probiotics in functional foods...
  18. pmc Human intestinal dendritic cells decrease cytokine release against Salmonella infection in the presence of Lactobacillus paracasei upon TLR activation
    Miriam Bermudez-Brito
    Institute of Nutrition and Food Technology José Mataix, Biomedical Research Centre, Department of Biochemistry and Molecular Biology II, University of Granada, Granada, Spain
    PLoS ONE 7:e43197. 2012
    ..The use of supernatants like the one described in this paper could be an effective and safe alternative to using live bacteria in functional foods...
  19. doi request reprint Influence of variants in the NPY gene on obesity and metabolic syndrome features in Spanish children
    Josune Olza
    Department of Biochemistry and Molecular Biology II, Institute of Nutrition and Food Technology, University of Granada, Center of Biomedical Research, Laboratory 123, Avenida del Conocimiento s n, 18016 Armilla, Granada, Spain
    Peptides 45:22-7. 2013
    ....
  20. ncbi request reprint Exogenous nucleosides accelerate differentiation of rat intestinal epithelial cells
    Jose María Vieites
    Department of Biochemistry and Molecular Biology II, School of Pharmacy, University of Granada, Granada, 18071, Spain
    Br J Nutr 99:732-8. 2008
    ....
  21. ncbi request reprint Dietary nucleotides accelerate changes in intestinal lymphocyte maturation in weanling mice
    Manuel Manzano
    R and D Department, Abbott Laboratories, Granada, Spain
    J Pediatr Gastroenterol Nutr 37:453-61. 2003
    ..The authors evaluated the influence of dietary nucleotides on the expression of several surface antigens by different intestinal lymphocyte populations in weanling mice...
  22. pmc Influence of FTO variants on obesity, inflammation and cardiovascular disease risk biomarkers in Spanish children: a case-control multicentre study
    Josune Olza
    Department of Biochemistry and Molecular Biology II, Faculty of Pharmacy Institute of Nutrition and Food Technology, University of Granada, Granada, Spain
    BMC Med Genet 14:123. 2013
    ....
  23. ncbi request reprint Curcumin ameliorates rabbits's steatohepatitis via respiratory chain, oxidative stress, and TNF-alpha
    M Carmen Ramirez-Tortosa
    Department of Biochemistry and Molecular Biology II, 18071 University of Granada, Spain
    Free Radic Biol Med 47:924-31. 2009
    ..Vitamin E treatment was unable to reduce NASH. In conclusion, curcumin might be useful in the management of NASH through a mechanism involving the antioxidant, anti-inflammatory, and mitochondrial-protective potential of curcumin...
  24. doi request reprint Isolation, identification and characterisation of three novel probiotic strains (Lactobacillus paracasei CNCM I-4034, Bifidobacterium breve CNCM I-4035 and Lactobacillus rhamnosus CNCM I-4036) from the faeces of exclusively breast-fed infants
    Sergio Muñoz-Quezada
    Department of Biochemistry and Molecular Biology II, Instituto de Nutrición y Tecnología de los Alimentos José Mataix INyTA, Centro de Investigación Biomédica CIBM, Universidad de Granada, Avenida del Conocimiento s n, 18100 Armilla, Granada, Spain
    Br J Nutr 109:S51-62. 2013
    ..Overall, these results suggest that L. paracasei CNCM I-4034, B. breve CNCM I-4035 and L. rhamnosus CNCM I-4036 should be considered as probiotic strains, and their human health benefits should be further evaluated...
  25. ncbi request reprint Exogenous nucleosides stimulate proliferation of fetal rat hepatocytes
    María José Sáez-Lara
    Department of Biochemistry and Molecular Biology, School of Pharmacy, University of Granada, Spain
    J Nutr 134:1309-13. 2004
    ..These results suggest that exogenous NS may in fact stimulate proliferation of hepatic cells and help preserve the undifferentiated state of fetal rat hepatocytes...
  26. ncbi request reprint Lactobacillus rhamnosus and its cell-free culture supernatant differentially modulate inflammatory biomarkers in Escherichia coli-challenged human dendritic cells
    Miriam Bermudez-Brito
    Department of Biochemistry and Molecular Biology II, Institute of Nutrition and Food Technology José Mataix INyTA, Biomedical Research Center, University of Granada, Avenida del Conocimiento s n, Armilla 18100, Granada, Spain
    Br J Nutr 111:1727-37. 2014
    ..In conclusion, the CFS exhibited an extraordinary ability to suppress the production of pro-inflammatory cytokines by DC, and may be used as an effective and safer alternative to live bacteria. ..
  27. ncbi request reprint The antioxidant effect of β-caryophyllene protects rat liver from carbon tetrachloride-induced fibrosis by inhibiting hepatic stellate cell activation
    Miguel Angel Calleja
    UGC Farmacia, Hospital Universitario Virgen de las Nieves, Granada, Spain
    Br J Nutr 109:394-401. 2013
    ..CAR, a sesquiterpene present in numerous plants and foods, is as a natural antioxidant that reduces carbon tetrachloride-mediated liver fibrosis and inhibits hepatic cell activation...
  28. doi request reprint Postprandial glucose, insulin and gastrointestinal hormones in healthy and diabetic subjects fed a fructose-free and resistant starch type IV-enriched enteral formula
    Cruz Erika García-Rodríguez
    Department of Biochemistry and Molecular Biology II, Institute of Nutrition and Food Technology José Mataix, Biomedical Research Centre, University of Granada, Avenida del Conocimiento s n, 18100 Armilla, Granada, Spain
    Eur J Nutr 52:1569-78. 2013
    ..Reducing the dietary glycaemic response has been proposed as a means of reducing the risk of diabetes...
  29. ncbi request reprint Dietary nucleotides modulate mitochondrial function of intestinal mucosa in weanling rats with chronic diarrhea
    Alexandra Arnaud
    R and D Department, Abbott Laboratories, Ross Products Division, Granada, Spain
    J Pediatr Gastroenterol Nutr 37:124-31. 2003
    ....
  30. ncbi request reprint Ribonucleic acid hydrolysis by intestinal explants of neonatal piglets
    Ricardo Rueda
    R and D Department, Ross Products Division, Abbott Laboratories, Granada, Spain
    J Pediatr Gastroenterol Nutr 35:685-90. 2002
    ..However, little is directly known of the ability of infants to hydrolyze nucleic acids early in life...
  31. doi request reprint In vitro cell and tissue models for studying host-microbe interactions: a review
    Miriam Bermudez-Brito
    Department of Biochemistry and Molecular Biology II, School of Pharmacy and Institute of Nutrition and Food Technology José Mataix, Biomedical Research Centre, University of Granada, Granada, Spain
    Br J Nutr 109:S27-34. 2013
    ..The present review details the in vitro models used to study host-microbe interactions and explores the new tools that may help in understanding the molecular mechanisms of these interactions...
  32. ncbi request reprint Monounsaturated and omega-3 but not omega-6 polyunsaturated fatty acids improve hepatic fibrosis in hypercholesterolemic rabbits
    Concepcion M Aguilera
    Department of Biochemistry and Molecular Biology, Institute of Nutrition and Food Technology, University of Granada, Granada, Spain
    Nutrition 21:363-71. 2005
    ....
  33. pmc Are Catalase -844A/G Polymorphism and Activity Associated with Childhood Obesity?
    Azahara I Rupérez
    1 Department of Biochemistry and Molecular Biology II, Institute of Nutrition and Food Technology, Centre of Biomedical Research, University of Granada, Granada, Spain
    Antioxid Redox Signal 19:1970-5. 2013
    ..We hypothesize that CAT plays a role in early metabolic complications of obesity. Antioxid. Redox Signal. 19, 1970-1975. ..
  34. ncbi request reprint Dietary nucleotides enhance the liver redox state and protein synthesis in cirrhotic rats
    Maria José Perez
    Department of Biochemistry and Molecular Biology, University of Granada, Granada, Spain
    J Nutr 134:2504-8. 2004
    ....
  35. ncbi request reprint Contribution of polyunsaturated fatty acids to intestinal repair in protein-energy malnutrition
    Natalia Nieto
    Department of Biochemistry and Molecular Biology, School of Pharmacy, University of Granada, Campus Universitario de Cartuja s n, Granada, Spain
    Dig Dis Sci 52:1485-96. 2007
    ..These results suggest that dietary polyunsaturated fatty acids, particularly those in the n-3 series, may play an important role in intestinal repair in chronic diarrhea due to protein-energy malnutrition...
  36. doi request reprint Sources, isolation, characterisation and evaluation of probiotics
    Luis Fontana
    Department of Biochemistry and Molecular Biology II, School of Pharmacy and Institute of Nutrition and Food Technology José Mataix, Biomedical Research Centre, University of Granada, Granada, Spain
    Br J Nutr 109:S35-50. 2013
    ..However, the most reliable method of assessing the therapeutic benefits of any probiotic strain is the use of randomised, placebo-controlled trials, which are reviewed in this article [corrected]...
  37. pmc Effects of Lactobacillus paracasei CNCM I-4034, Bifidobacterium breve CNCM I-4035 and Lactobacillus rhamnosus CNCM I-4036 on hepatic steatosis in Zucker rats
    Julio Plaza-Díaz
    Department of Biochemistry and Molecular Biology II, School of Pharmacy, University of Granada, Granada, Spain Institute of Nutrition and Food Technology José Mataix, Biomedical Research Center, University of Granada, Granada, Spain
    PLoS ONE 9:e98401. 2014
    ..paracasei feeding decreased IL-6 levels in the serum of Zucker-Lepr(fa/fa) rats. In conclusion, the probiotic strains reduced hepatic steatosis in part by lowering serum LPS, and had an anti-inflammatory effect in obese Zucker rats...
  38. doi request reprint Probiotic mechanisms of action
    Miriam Bermudez-Brito
    Department of Biochemistry and Molecular Biology II, Institute of Nutrition and Food Technology José Mataix, Biomedical Research Center, University of Granada, Armilla, Spain
    Ann Nutr Metab 61:160-74. 2012
    ..The goal of this systematic review was to explore probiotic modes of action focusing on how gut microbes influence the host...
  39. ncbi request reprint Effects of lifestyle modification and lipid intake variations on patients with peripheral vascular disease
    Teresa Nestares
    Institute of Nutrition and Food Technology, Department of Physiology, University of Granada
    Int J Vitam Nutr Res 73:389-98. 2003
    ..The lifestyle intervention program, together with a high intake of olive plus fish oil, seems to produce important beneficial effects in nutritional management, physical performance, and clinical parameters of PVD patients...
  40. doi request reprint Effects of fish oil supplementation on the fatty acid profile in erythrocyte membrane and plasma phospholipids of pregnant women and their offspring: a randomised controlled trial
    M Victoria Escolano-Margarit
    Department of Pediatrics, School of Medicine, University of Granada, Avenida de Madrid 11, Granada, Spain
    Br J Nutr 109:1647-56. 2013
    ..FO supplementation increases maternal and fetal DHA status. Both plasma and erythrocytes appear to be suitable to evaluate the fatty acid status of mothers but erythrocytes seem to be a more reliable marker in neonates...
  41. pmc Myeloperoxidase is an early biomarker of inflammation and cardiovascular risk in prepubertal obese children
    Josune Olza
    Department of Biochemistry and Molecular Biology II, Institute of Nutrition and Food Technology, Center for Biomedical Research, University of Granada, Granada, Spain
    Diabetes Care 35:2373-6. 2012
    ..The objectives of the current study were to evaluate plasma MPO levels in prepubertal obese children and to determine whether MPO could be an early biomarker of inflammation and CVD risk...
  42. doi request reprint Omega-3 long-chain polyunsaturated fatty acids supplementation on inflammatory biomakers: a systematic review of randomised clinical trials
    Oscar D Rangel-Huerta
    Department of Biochemistry and Molecular Biology Molecular II, Institute of Nutrition and Food Technology, Jose Mataix Biomedical Research Centre, University of Granada, Granada, Spain
    Br J Nutr 107:S159-70. 2012
    ..However, further research is required before definitive recommendations can be made about the routine use of omega-3 fatty acids in critically ill patients or with neurodegenerative or chronic renal disease...
  43. doi request reprint Three main factors define changes in fecal microbiota associated with feeding modality in infants
    Carolina Gómez-Llorente
    Department of Biochemistry and Molecular Biology II Department of Microbiology, Institute of Nutrition and Food Technology Jose Mataix Biomedical Research Center, University of Granada, Armilla, Granada Department of Food Science and Nutrition, Veterinary Faculty, University of Murcia Hero Global Technology Center for Infant Nutrition, Hero Group, Alcantarilla Pediatric Service, Virgen de la Arrixaca Hospital, Murcia, Spain
    J Pediatr Gastroenterol Nutr 57:461-6. 2013
    ....
  44. pmc Safety and immunomodulatory effects of three probiotic strains isolated from the feces of breast-fed infants in healthy adults: SETOPROB study
    Julio Plaza-Díaz
    Department of Biochemistry and Molecular Biology II, School of Pharmacy, University of Granada, Granada, Spain Institute of Nutrition and Food Technology José Mataix, Biomedical Research Center, University of Granada, Granada, Spain
    PLoS ONE 8:e78111. 2013
    ..These results demonstrate that the consumption of these three bacterial strains was safe and exerted varying degrees of immunomodulatory effects...
  45. ncbi request reprint Oxidative stress status in an institutionalised elderly group after the intake of a phenolic-rich dessert
    M Carmen Ramirez-Tortosa
    Department of Biochemistry and Molecular Biology, Institute of Nutrition and Food Technology, University of Granada, Campus de Cartuja, 18071 Granada, Spain
    Br J Nutr 91:943-50. 2004
    ..Moreover, a highly oxidative stress status during ageing was confirmed, together with the need to perform follow-up nutritional studies to improve this situation...
  46. doi request reprint Bioactive anti-obesity food components
    Olga Martínez-Augustin
    Department of Biochemistry and Molecular Biology II, University of Granada, Spain
    Int J Vitam Nutr Res 82:148-56. 2012
    ..The purpose of this review is to examine, from a critical point of view, food components currently used by health professionals and by the general population as coadjuvants in the prevention of obesity...
  47. ncbi request reprint Xenotransplantation of human umbilical cord blood mononuclear cells to rats with D-galactosamine-induced hepatitis
    Ana I Alvarez-Mercado
    Department of Biochemistry and Molecular Biology II, School of Pharmacy, Campus de Cartuja s n, 18071 Granada, Spain
    Cell Transplant 17:845-57. 2008
    ..Results obtained suggest that HUCBM cells are capable of hepatic engraftment in this human-to-rat xenotransplant model and that transplantation of HUCBM cells may be a suitable therapy for liver disease...
  48. doi request reprint Influence of an eicosapentaenoic and docosahexaenoic acid-enriched enteral nutrition formula on plasma fatty acid composition and biomarkers of insulin resistance in the elderly
    Josune Olza
    Department of Biochemistry and Molecular Biology II, Institute of Nutrition and Food Technology, Biomedical Research Centre, University of Granada, Granada, Spain
    Clin Nutr 29:31-7. 2010
    ....
  49. ncbi request reprint [Protective effect of monounsaturated and polyunsaturated fatty acids on the development of cardiovascular disease]
    C M Aguilera
    , , Granada,
    Nutr Hosp 16:78-91. 2001
    ....
  50. doi request reprint Role of Toll-like receptors in the development of immunotolerance mediated by probiotics
    Carolina Gómez-Llorente
    Department of Biochemistry and Molecular Biology II, Institute of Nutrition and Food Technology, Centre of Biomedical Research, University of Granada, Avda Conocimiento s n, 18100 Armilla, Granada, Spain
    Proc Nutr Soc 69:381-9. 2010
    ..The aim of the present work was to review the function of TLR in the development of immunotolerance and examine the specific role of probiotics in the regulation of tolerance to antigens...
  51. ncbi request reprint Transplantation of human CD34+ stem cells from umbilical cord blood to rats with thioacetamide-induced liver cirrhosis
    María José Sáez-Lara
    Department of Biochemistry and Molecular Biology, School of Pharmacy, University of Granada, Granada, Spain
    Xenotransplantation 13:529-35. 2006
    ..The aim of this work was to investigate whether transplantation of hematopoietic CD34(+) stem cells could improve hepatic fibrosis by their differentiation into hepatocytes...
  52. ncbi request reprint Does consumption of two portions of salmon per week enhance the antioxidant defense system in pregnant women?
    Cruz E García-Rodríguez
    Department of Biochemistry and Molecular Biology II, Biomedical Research Center, Institute of Nutrition and Food Technology José Mataix, University of Granada, Granada, Spain
    Antioxid Redox Signal 16:1401-6. 2012
    ..Collectively, our findings lead to the hypothesis that increased farmed salmon intake may increase antioxidant defenses during pregnancy. Clinical trials identifier NCT00801502...
  53. pmc A specific protein-enriched enteral formula decreases cortisolemia and improves plasma albumin and amino acid concentrations in elderly patients
    Josune Olza
    Department of Biochemistry and Molecular Biology II, Institute of Nutrition and Food Technology, Biomedical Research Center, University of Granada, Granada, Spain
    Nutr Metab (Lond) 7:58. 2010
    ....
  54. doi request reprint Prenatal DHA status and neurological outcome in children at age 5.5 years are positively associated
    M Victoria Escolano-Margarit
    Department of Paediatrics, University of Granada, 18012 Granada, Spain
    J Nutr 141:1216-23. 2011
    ..262), erythrocyte phosphatidylethanolamine (95% CI: 1.091-2.417), and erythrocyte phosphatidylcholine (95% CI: 1.003-2.643). We conclude that higher DHA levels in cord blood may be related to a better neurological outcome at 5.5 y of age...
  55. doi request reprint Is adipose tissue metabolically different at different sites?
    Angel Gil
    Department of Biochemistry and Molecular Biology, Institute of Nutrition and Food Technology, Centre for Biomedical Research, University of Granada, Granada, Spain
    Int J Pediatr Obes 6:13-20. 2011
    ..Current research is investigating various approaches of BAT and SWAT transplantation, including new sources of adipocyte progenitors. This may be important for the potential treatment of childhood obesity...
  56. ncbi request reprint Olive oil- and fish oil-enriched diets modify plasma lipids and susceptibility of LDL to oxidative modification in free-living male patients with peripheral vascular disease: the Spanish Nutrition Study
    C Ramirez-Tortosa
    Institute of Nutrition and Food Technology, University of Granada, Spain
    Br J Nutr 82:31-9. 1999
    ....
  57. ncbi request reprint Protective effects of Rosmarinus tomentosus ethanol extract on thioacetamide-induced liver cirrhosis in rats
    M Galisteo
    Facultad de Farmacia, Departamento de Farmacologia, Universidad de Granada, Granada, Spain
    Phytomedicine 13:101-8. 2006
    ..tomentosus ethanol extract administered in the diet affords protection against TAA-induced cirrhosis, preventing most of the histological changes and functionality alterations own to this experimental pathology...
  58. ncbi request reprint Sunflower, virgin-olive and fish oils differentially affect the progression of aortic lesions in rabbits with experimental atherosclerosis
    C M Aguilera
    Department of Biochemistry and Molecular Biology, Institute of Nutrition and Food Technology, University of Granada, C Ramon y Cajal, 4, 18071, Granada, Spain
    Atherosclerosis 162:335-44. 2002
    ..However, sunflower oil provokes a significant progression in lesion development, whereas diet enrichment with extra virgin olive oil and, to a lesser extent, fish oil, stops this progression...
  59. ncbi request reprint [Intake of an iron-supplemented milk formula as a preventive measure to avoid low iron status in 1-3 year-olds]
    J Maldonado Lozano
    Departmento de Pediatria, Facultad de Medicina, Universidad de Granada, Espana
    An Pediatr (Barc) 66:591-6. 2007
    ..Low iron status is a well known risk factor for iron deficiency anemia in infants and young children. The aim of the present study was to evaluate the influence of an iron-fortified toddler formula on iron status in 1-3 year-olds...
  60. ncbi request reprint Transplantation of green fluorescent hepatic stellate cells into rat livers
    L Fontana
    Department of Biochemistry and Molecular Biology, School of Pharmacy, University of Granada, Granada, Spain
    Transplant Proc 34:1073-5. 2002
  61. ncbi request reprint Proliferation, functionality, and extracellular matrix production of hepatocytes and a liver stellate cell line: a comparison between single cultures and cocultures
    Alexandra Arnaud
    R and D Department, Abbott Laboratories, Granada, Spain
    Dig Dis Sci 48:1406-13. 2003
    ..Cocultures of activated CFSC-2G and healthy hepatocytes are a useful model to study fibrogenesis in vitro since various functional alterations found in this pathology are reproduced...
  62. doi request reprint Wholegrain cereals and bread: a duet of the Mediterranean diet for the prevention of chronic diseases
    Angel Gil
    1Department of Biochemistry and Molecular Biology II, Centre for Biomedical Research CIB, Institute of Nutrition and Food Technology, University of Granada, Avda del Conocimiento s n, 18100 Armilla, Granada, Spain
    Public Health Nutr 14:2316-22. 2011
    ..The aim of the present work is to review the fundamental studies that support the consumption of wholegrain cereals and bread to prevent chronic diseases...
  63. ncbi request reprint Dietary polyunsaturated fatty acids improve histological and biochemical alterations in rats with experimental ulcerative colitis
    Natalia Nieto
    Department of Biochemistry and Molecular Biology, University of Granada, 18071 Granada, Spain
    J Nutr 132:11-9. 2002
    ..These results suggest that the use of balanced diets containing (n-3) LC-PUFA could ameliorate the inflammation and mucosal damage in UC...
  64. ncbi request reprint Serum amino acid changes in rats with thioacetamide-induced liver cirrhosis
    L Fontana
    Departamento de Bioquimica y Biologia Molecular, Facultad de Farmacia, Universidad de Granada, Spain
    Toxicology 106:197-206. 1996
    ..In contrast, alkaline phosphatase rose dramatically in cirrhotic rats. We conclude that the serum amino acid pattern in this chronic model of liver cirrhosis resembles in part that of the corresponding human disease...
  65. ncbi request reprint Addition of vitamin E to long-chain polyunsaturated fatty acid-enriched diets protects neonatal tissue lipids against peroxidation in rats
    A Suarez
    Department of Biochemistry and Molecular Biology, Faculty of Pharmacy, University of Granada, E 18071, Granada, Spain
    Eur J Nutr 38:169-76. 1999
    ..Diet-derived antioxidants like vitamin E play a key role in the protection of tissue lipids against oxidation...
  66. pmc Genetics of oxidative stress in obesity
    Azahara I Rupérez
    Department of Biochemistry and Molecular Biology II, Institute of Nutrition and Food Technology, Centre for Biomedical Research, University of Granada, 18100 Armilla, Granada, Spain
    Int J Mol Sci 15:3118-44. 2014
    ....
  67. ncbi request reprint Characterization of human cd200 glycoprotein receptor gene located on chromosome 3q12-13
    José María Vieites
    Department of Biochemistry and Molecular Biology, University of Granada, 18071 Granada, Spain
    Gene 311:99-104. 2003
    ..By RT-PCR, we have analyzed the expression of the four transcript variants in human placenta, spleen, liver, brain and kidney...
  68. ncbi request reprint Curcuma longa extract supplementation reduces oxidative stress and attenuates aortic fatty streak development in rabbits
    Jose L Quiles
    Department of Physiology, Granada University, Granada, Spain
    Arterioscler Thromb Vasc Biol 22:1225-31. 2002
    ..This study evaluates the effect of a Curcuma longa extract on the development of experimental atherosclerosis (fatty streak) in rabbits and its interaction with other plasmatic antioxidants...
  69. ncbi request reprint Absolute counts and distribution of lymphocyte subsets in small intestine of BALB/c mice change during weaning
    Manuel Manzano
    R and D Department, Abbott Laboratories, Granada, Spain
    J Nutr 132:2757-62. 2002
    ..Thus, B cells increase in PPL and T cell increase in IEL and LPL...
  70. ncbi request reprint Dietary nucleotide supplementation reduces thioacetamide-induced liver fibrosis in rats
    Maria José Perez
    Department of Biochemistry and Molecular Biology, University of Granada, Granada, Spain
    J Nutr 132:652-7. 2002
    ..05). These data indicate that the reduction of liver fibrosis in nucleotide-supplemented rats may rely on the enhancement of collagenase activity and the reduction of collagen content and maturation...
  71. ncbi request reprint The influence of dietary nucleotides on humoral and cell immunity in the neonate and lactating infant
    J Maldonado
    Department of Paediatrics, Facultad de Medicina, University of Granada, Avda. de Madrid s/n, 18012, Granada, Spain
    Early Hum Dev 65:S69-74. 2001
    ..Therefore, the addition of nucleotides to formula appears to favour the immune function...
  72. ncbi request reprint Oral administration of a turmeric extract inhibits LDL oxidation and has hypocholesterolemic effects in rabbits with experimental atherosclerosis
    M C Ramirez-Tortosa
    Department of Biochemistry and Molecular Biology, University of Granada, Faculty of Pharmacy, Campus de Cartuja 18071, Granada, Spain
    Atherosclerosis 147:371-8. 1999
    ..2-mg dosage. In conclusion, the use of this extract could be useful in the management of cardiovascular disease in which atherosclerosis is important...
  73. ncbi request reprint Nucleotides as semiessential nutritional components
    A Sanchez-Pozo
    Department of Biochemistry and Molecular Biology, Faculty of Pharmacy, University of Granada, Spain
    Br J Nutr 87:S135-7. 2002
    ..Dietary nucleotides can also modulate gene expression by interaction with specific transcription factors, in both the liver and the small intestine...
  74. doi request reprint Faecal microbiota and short-chain fatty acid levels in faeces from infants with cow's milk protein allergy
    Oscar C Thompson-Chagoyan
    Department of Biochemistry and Molecular Biology II, Institute of Nutrition and Food Technology, Centre for Biomedical Research, University of Granada, Granada, Spain
    Int Arch Allergy Immunol 156:325-32. 2011
    ..The present study was designed to compare the faecal microbiota and concentrations of faecal short-chain fatty acid and ammonia between healthy and cow's milk protein allergic (CMPA) infants...
  75. ncbi request reprint Exogenous nucleosides alter the intracellular nucleotide pool in hepatic cell cultures. Implications in cell proliferation and function
    A Arnaud
    R and D Department, Abbott Laboratories, Granada, Spain
    Clin Nutr 22:391-9. 2003
    ..The objective of the study was to evaluate the uptake and incorporation of exogenous nucleosides by hepatic cells, and the potential implications for cell proliferation and function...
  76. pmc Abnormalities in plasma and red blood cell fatty acid profiles of patients with colorectal cancer
    L Baro
    Department of Biochemistry and Molecular Biology, Institute of Nutrition and Food Technology, University of Granada, Spain
    Br J Cancer 77:1978-83. 1998
    ..These changes are probably due to metabolic changes caused by the illness per se but not to malnutrition...
  77. ncbi request reprint Absorption and distribution of dietary fatty acids from different sources
    M Ramirez
    Research and Development Department, Ross Product Division, Abbott Laboratories, Camino de Purchill 68, 18004, Granada, Spain
    Early Hum Dev 65:S95-S101. 2001
    ..Fatty acids esterified as PL or TG may show different availability. In fact, some authors have suggested a better absorption of LCP-PL. Moreover, dietary LCP in form of TG or PL differently affects the composition of HDL and LDL PL...
  78. ncbi request reprint Positional analysis of triglycerides and phospholipids rich in long-chain polyunsaturated fatty acids
    L Amate
    Research and Development Department, Ross Product Division, Abbott Laboratories, Granada, Spain
    Lipids 34:865-71. 1999
    ..These results show a different fatty acid composition and distribution of dietary LCP sources, which may affect the absorption, distribution, and tissue uptake of LCP, and should be taken into account when supplementing infant formulas...
  79. ncbi request reprint Nutritional risks in the Spanish population: results of the eVe study
    R M Ortega
    Departamento de Nutricion, Facultad de Farmacia, Universidad Complutense, Madrid, Spain
    Eur J Clin Nutr 57:S73-5. 2003
    ..To determine the vitamin status of different groups within the Spanish population...
  80. ncbi request reprint [Nutritional and antioxidant status of an institutionalized elderly group in Murcia (Spain)]
    Javier García-Alonso
    Facultad de Veterinaria y Ciencia de los Alimentos, Universidad de Murcia, Campus de Espinardo, Murcia, Espana
    Arch Latinoam Nutr 54:180-9. 2004
    ..Although total plasma antioxidant status was low (0.62 mM eq Trolox and 0.98 mM eq Fe(II)) compared with reference values, estimated oxidative risk in this group of elderly was low according to plasma levels of vitamins C, A & E...
  81. ncbi request reprint Dietary long-chain PUFA in the form of TAG or phospholipids influence lymph lipoprotein size and composition in piglets
    Laura Amate
    Research and Development Department, Abbott Laboratories, 18004 Granada, Spain
    Lipids 37:975-80. 2002
    ..0.29 +/- 0.04 and 0.12 +/- 0.03 g/100 g, respectively). The addition to the diet of LCP in the form of TAG or PL affected the size of intestinal lipoproteins and also led to a different distribution of these FA in lymph lipoproteins...
  82. ncbi request reprint Seroprevalence of pertussis antibody among health care personnel in Spain
    José Ramón de Juanes
    Preventive Medicine Service, 12 de Octubre University Hospital, Madrid, Spain
    Eur J Epidemiol 19:69-72. 2004
    ..pertussis. Fifty percent of physicians and nursing personnel working in hospital were seronegative for pertussis antibody. A high percentage of these subjects will be susceptible to infection...
  83. ncbi request reprint Ghrelin: a hormone regulating food intake and energy homeostasis
    Mercedes Gil-Campos
    Unit of Paediatric Endocrinology, Reina Sofia University Hospital, Cordoba, Spain
    Br J Nutr 96:201-26. 2006
    ..Relationships with leptin and insulin in the regulation of energy homeostasis are addressed...
  84. ncbi request reprint Hospitalization by pneumonia and influenza in the 50-64 year old population in Spain (1999-2002)
    Angel Gil
    Department of Health Sciences, Rey Juan Carlos University, Alcorcon, Madrid, Spain
    Hum Vaccin 2:181-4. 2006
    ..Preventive measures, such as vaccination will reduce pneumonia-related morbidity and could result in large cost savings to the Health Care System...
  85. ncbi request reprint Effects of fish-oil and folate supplementation of pregnant women on maternal and fetal plasma concentrations of docosahexaenoic acid and eicosapentaenoic acid: a European randomized multicenter trial
    Susanne Krauss-Etschmann
    Clinical Cooperation Group Pediatric Immune Regulation, Ludwig Maximilians University, Munich, Germany
    Am J Clin Nutr 85:1392-400. 2007
    ..The supply of both folic acid and docosahexaenoic acid (DHA) has been related to positive pregnancy and infant outcomes...
  86. ncbi request reprint Ten-year trends in self-rated health among Spanish adults with diabetes, 1993 2003
    Rodrigo Jimenez-Garcia
    Preventive Medicine Unit, Rey Juan Carlos University, Alcorcon, Spain
    Diabetes Care 31:90-2. 2008
    ....
  87. ncbi request reprint Burden of hospital admissions for cervical cancer in Spain during 1999-2002
    Angel Gil
    Department of Health Sciences, Rey Juan Carlos University, Madrid, Spain
    Hum Vaccin 3:276-80. 2007
    ..The mean cost of a hospitalization by cervical cancer and carcinoma in situ euro3,098 and euro2,192, respectively. The estimated annual cost of hospitalizations cervical cancer and carcinoma in situ in Spain was 19 million euro...
  88. doi request reprint Hormone levels in 12- to 15-year-old boys and girls in Spain and their relationship with anthropometric variables
    Carmen Garces
    Lipid Unit, Fundacion Jimenez Diaz, Universidad Autonoma de Madrid, Spain
    Clin Biochem 41:621-4. 2008
    ..To determine hormone levels in a population-based sample of pubertal children and evaluate their association with anthropometric parameters...
  89. ncbi request reprint [The epidemiology of hospital admissions due to leishmaniasis in Spain (1999-2003)]
    Yolanda Valcárcel
    Unidad de Docencia e Investigacion en Medicina Preventiva y Salud Publica, Facultad de Ciencias de la Salud, Madrid, Espana
    Enferm Infecc Microbiol Clin 26:278-81. 2008
    ..The aim of this study was to determine the epidemiology of patients hospitalized for leishmaniasis during the period 1999 to 2003...
  90. ncbi request reprint Aetiology of inflammatory bowel disease (IBD): role of intestinal microbiota and gut-associated lymphoid tissue immune response
    Oscar C Thompson-Chagoyan
    Department of Paediatrics, Los Venados General Hospital, Mexican Institute of Social Security, Mexico City, Mexico
    Clin Nutr 24:339-52. 2005
    ....
  91. ncbi request reprint [Sensitivity to change and minimally important difference of the Spanish version of the life-satisfaction questionnaire LISAT-8 in male patients with erectile dysfunction]
    Javier Rejas
    Departamento de Farmacoepidemiología y Farmacovigilancia, Unidad Médica, Pfizer S A, Madrid, Spain
    Med Clin (Barc) 124:165-71. 2005
    ..We determined the sensitivity to change and minimally important difference (MID) of the Spanish version of the life-satisfaction check list LISAT-8...
  92. ncbi request reprint Epidemiology of severe varicella-zoster virus infection in Spain
    Angel Gil
    Department of Health Sciences, Rey Juan Carlos University, Avda de Atenas s n, 28922 Alcorcon, Madrid, Spain
    Vaccine 22:3947-51. 2004
    ..Hospitalizations for varicella and herpes zoster resulted annually in 11,141 and 40,090 days of hospitalization and a cost of 3.2 and 7.0 million, respectively...
  93. ncbi request reprint The burden of severe varicella in Spain, 1995--2000 period
    Angel Gil
    Department of Health Sciences, Rey Juan Carlos University, Avda de Atenas s n, Alcorcon, Spain
    Eur J Epidemiol 19:699-702. 2004
    ..Population-based estimates of hospitalization rates for varicella provide data of the severe and costly end of this disease...
  94. ncbi request reprint Adiponectin, the missing link in insulin resistance and obesity
    Mercedes Gil-Campos
    Unit of Paediatric Endocrinology, University Hospital Reina Sofia, Avda Menendez Pidal, 14004 Cordoba, Spain
    Clin Nutr 23:963-74. 2004
    ..Since there is no available recombinant adiponectin for human use, its direct effects on human metabolism remain unknown, but this hormone appears to be promising in the treatment of obesity an related metabolic disorders...
  95. ncbi request reprint Dietary trans fatty acids alter the compositions of microsomes and mitochondria and the activities of microsome delta6-fatty acid desaturase and glucose-6-phosphatase in livers of pregnant rats
    Elvira Larque
    Department of Physiology, University of Murcia, Murcia, Spain
    J Nutr 133:2526-31. 2003
    ..This effect might contribute to low delta6-desaturase and glucose-6-phosphatase activities in liver microsomes of pregnant rats...
  96. ncbi request reprint Influenza coverages in Spain and vaccination-related factors in the subgroup aged 50-64 years
    Rodrigo Jiménez
    Unidad de Docencia e Investigacion en Medicina Preventiva y Salud Publica, Facultad de Ciencias de la Salud, Universidad Rey Juan Carlos, Avenida de Atenas s n, Alcorcon, 28402 Madrid, Spain
    Vaccine 21:3550-5. 2003
    ..We conclude that the extremely high number of subjects in the 50-64 age range susceptible to influenza-related complications each year constitutes good grounds for universal vaccination being extended to said age group...
  97. ncbi request reprint Consistently high plasma high-density lipoprotein-cholesterol levels in children in Spain, a country with low cardiovascular mortality
    Carmen Garces
    Lipid Unit, Fundacion Jimenez Diaz, Universidad Autonoma de Madrid, Spain
    Metabolism 53:1045-7. 2004
    ..These high levels of plasma HDL-C in Spanish school children may help to explain why the coronary heart disease mortality rate in Spain is low compared with that in other developed countries...
  98. ncbi request reprint Is eicosapentaenoic acid useful in the treatment of ulcerative colitis in children?
    Angel Gil
    J Pediatr Gastroenterol Nutr 37:536-7. 2003
  99. ncbi request reprint [Occupational injury in foreign workers by economic activity and autonomous community (Spain 2005)]
    Ma José López-Jacob
    Instituto Sindical de Trabajo, Ambiente y Salud
    Rev Esp Salud Publica 82:179-87. 2008
    ..The objective of this study was to compare the incidences for both fatal and non-fatal injuries in foreign workers to that of Spanish workers in 2005, by autonomous community and economic activity...