Affiliation: University of Navarra
Roman M, Lopez I, Guruceaga E, Baraibar I, Ecay M, Collantes M, et al
. Inhibitor of differentiation-1 (Id1) sustains mutant KRAS-driven progression, maintenance, and metastasis of lung adenocarcinoma via regulation of a FOSL1 network. Cancer Res. 2018;: pubmed publisher
..Our study provides clinical, functional, and mechanistic evidence underscoring Id1 as a critical gene in mutant KRAS LUAD and warrants further studies of Id1 as a therapeutic target in LUAD patients. ..
Castañon E, Martin P, Rolfo C, Fusco J, Ceniceros L, Legaspi J, et al
. Epidermal Growth Factor Receptor targeting in non-small cell lung cancer: revisiting different strategies against the same target. Curr Drug Targets. 2014;15:1273-83 pubmed
..New compounds under investigation targeting resistance mutations or dually targeting EGFR and other relevant receptors are also reviewed and discussed. ..
Ceniceros L, Aristu J, CastaÃ±Ã³n E, Rolfo C, Legaspi J, Olarte A, et al
. Stereotactic body radiotherapy (SBRT) for the treatment of inoperable stage I non-small cell lung cancer patients. Clin Transl Oncol. 2016;18:259-68 pubmed publisher
..According to the published evidence as well as our own experience, SBRT is a safe and feasible approach for early NSCLC. Its results may be comparable with surgery treatment. ..
CastaÃ±Ã³n E, Rolfo C, ViÃ±al D, LÃ³pez I, Fusco J, Santisteban M, et al
. Impact of epidermal growth factor receptor (EGFR) activating mutations and their targeted treatment in the prognosis of stage IV non-small cell lung cancer (NSCLC) patients harboring liver metastasis. J Transl Med. 2015;13:257 pubmed publisher
..81). Overall, liver metastases at onset negatively impact OS of NSCLC patients. EGFR TKIs however, may reverse the effects of an initial negative prognosis of liver metastasis in first-line treatment of EGFR mutated NSCLC patients. ..
Roman M, Baraibar I, Lopez I, Nadal E, Rolfo C, Vicent S, et al
. KRAS oncogene in non-small cell lung cancer: clinical perspectives on the treatment of an old target. Mol Cancer. 2018;17:33 pubmed publisher
CastaÃ±Ã³n E, Soltermann A, LÃ³pez I, RomÃ¡n M, Ecay M, Collantes M, et al
. The inhibitor of differentiation-1 (Id1) enables lung cancer liver colonization through activation of an EMT program in tumor cells and establishment of the pre-metastatic niche. Cancer Lett. 2017;402:43-51 pubmed publisher
..Therefore, Id1 enables both LLC and the host microenvironment for an effective liver colonization, and may represent a novel therapeutic target to avoid NSCLC liver metastasis. ..