Elena Garcia-Martin

Summary

Affiliation: University of Extremadura
Country: Spain

Publications

  1. pmc The diamine oxidase gene is associated with hypersensitivity response to non-steroidal anti-inflammatory drugs
    Jose A G Agundez
    Departamento de Farmacologia, Universidad de Extremadura, Caceres, Spain
    PLoS ONE 7:e47571. 2012
  2. pmc Analysis of the Functional Polymorphism in the Cytochrome P450 CYP2C8 Gene rs11572080 with Regard to Colorectal Cancer Risk
    Jose M Ladero
    Service of Gastroenterology, Hospital Clinico San Carlos, Instituto de Investigación Sanitaria del Hospital Clínico San Carlos Madrid, Spain Department of Medicine, Medical School, Universidad Complutense Madrid, Spain
    Front Genet 3:278. 2012
  3. ncbi request reprint Metabolic considerations of drugs in the treatment of allergic diseases
    Elena Garcia-Martin
    University of Extremadura, Department of Biochemistry and Molecular Biology, Avda de la Universidad s n, E 10071, Caceres, Spain 34927257000 ext 89676
    Expert Opin Drug Metab Toxicol 9:1437-52. 2013
  4. pmc LINGO1 rs9652490 and rs11856808 polymorphisms are not associated with risk for multiple sclerosis
    Elena Garcia-Martin
    Department of Biochemistry and Molecular Biology, University of Extremadura, Caceres, Spain
    BMC Neurol 13:34. 2013
  5. ncbi request reprint Improved analytical sensitivity reveals the occurrence of gender-related variability in diamine oxidase enzyme activity in healthy individuals
    Elena Garcia-Martin
    Department of Biochemistry and Molecular Biology, School of Biological Sciences, University of Extremadura, Avda de Elvas s n, 06071 Badajoz, Spain
    Clin Biochem 40:1339-41. 2007
  6. doi request reprint Histamine pharmacogenomics
    Elena Garcia-Martin
    University of Extremadura, Badajoz, Spain
    Pharmacogenomics 10:867-83. 2009
  7. ncbi request reprint Interethnic and intraethnic variability of NAT2 single nucleotide polymorphisms
    Elena Garcia-Martin
    Department of Biochemistry and Molecular Biology and Genetics, School of Biological Sciences, University of Extremadura, Avda de Elvas s n, E 06071, Badajoz, Spain
    Curr Drug Metab 9:487-97. 2008
  8. pmc Genetic variability of histamine receptors in patients with Parkinson's disease
    Elena Garcia-Martin
    Department of Biochemistry and Molecular Biology, School of Biological Sciences, University of Extremadura, Badajoz, Spain
    BMC Med Genet 9:15. 2008
  9. ncbi request reprint Dopamine receptor D3 (DRD3) genotype and allelic variants and risk for essential tremor
    Elena Garcia-Martin
    Department of Biochemistry and Molecular Biology, School of Biological Sciences, University of Extremadura, Badajoz, Spain
    Mov Disord 24:1910-5. 2009
  10. ncbi request reprint MAPT gene rs1052553 variant is not associated with the risk for multiple sclerosis
    Jose A G Agundez
    Department of Pharmacology, University of Extremadura, Caceres, Spain
    Hum Immunol 74:1705-8. 2013

Collaborators

Detail Information

Publications58

  1. pmc The diamine oxidase gene is associated with hypersensitivity response to non-steroidal anti-inflammatory drugs
    Jose A G Agundez
    Departamento de Farmacologia, Universidad de Extremadura, Caceres, Spain
    PLoS ONE 7:e47571. 2012
    ..7 (95% CI  = 1.3-2.1; Pc  = 0.0003) with a gene-dose effect (P = 0.0001). The association was replicated in two populations from different geographic areas (Pc  = 0.008 and Pc  = 0.004, respectively)...
  2. pmc Analysis of the Functional Polymorphism in the Cytochrome P450 CYP2C8 Gene rs11572080 with Regard to Colorectal Cancer Risk
    Jose M Ladero
    Service of Gastroenterology, Hospital Clinico San Carlos, Instituto de Investigación Sanitaria del Hospital Clínico San Carlos Madrid, Spain Department of Medicine, Medical School, Universidad Complutense Madrid, Spain
    Front Genet 3:278. 2012
    ..We conclude that the risk of developing colorectal cancer does not seem to be related to the commonest functional genetic variation in the CYP2C8 gene...
  3. ncbi request reprint Metabolic considerations of drugs in the treatment of allergic diseases
    Elena Garcia-Martin
    University of Extremadura, Department of Biochemistry and Molecular Biology, Avda de la Universidad s n, E 10071, Caceres, Spain 34927257000 ext 89676
    Expert Opin Drug Metab Toxicol 9:1437-52. 2013
    ..The clinical management of allergic diseases involves a number of drugs, most of which are extensively metabolized. This review aims to analyze the metabolism and the clinical implications of altered metabolism for these drugs...
  4. pmc LINGO1 rs9652490 and rs11856808 polymorphisms are not associated with risk for multiple sclerosis
    Elena Garcia-Martin
    Department of Biochemistry and Molecular Biology, University of Extremadura, Caceres, Spain
    BMC Neurol 13:34. 2013
    ..These SNPs are linked to several SNPs within the LINGO1 gene, especially in individuals of Oriental or Caucasian descent...
  5. ncbi request reprint Improved analytical sensitivity reveals the occurrence of gender-related variability in diamine oxidase enzyme activity in healthy individuals
    Elena Garcia-Martin
    Department of Biochemistry and Molecular Biology, School of Biological Sciences, University of Extremadura, Avda de Elvas s n, 06071 Badajoz, Spain
    Clin Biochem 40:1339-41. 2007
    ..4.3.6) activity is often employed as a clinical indicator of the integrity of intestinal mucosa. However, interindividual variation in enzyme activity and reference values for healthy women and men have not been studied...
  6. doi request reprint Histamine pharmacogenomics
    Elena Garcia-Martin
    University of Extremadura, Badajoz, Spain
    Pharmacogenomics 10:867-83. 2009
    ..This review summarizes relevant polymorphisms, discusses controversial findings on association of histamine-related polymorphisms and allergies and other diseases, and identifies topics requiring further investigation...
  7. ncbi request reprint Interethnic and intraethnic variability of NAT2 single nucleotide polymorphisms
    Elena Garcia-Martin
    Department of Biochemistry and Molecular Biology and Genetics, School of Biological Sciences, University of Extremadura, Avda de Elvas s n, E 06071, Badajoz, Spain
    Curr Drug Metab 9:487-97. 2008
    ....
  8. pmc Genetic variability of histamine receptors in patients with Parkinson's disease
    Elena Garcia-Martin
    Department of Biochemistry and Molecular Biology, School of Biological Sciences, University of Extremadura, Badajoz, Spain
    BMC Med Genet 9:15. 2008
    ..This study is aimed to analyse polymorphic variations of HRH in patients with PD...
  9. ncbi request reprint Dopamine receptor D3 (DRD3) genotype and allelic variants and risk for essential tremor
    Elena Garcia-Martin
    Department of Biochemistry and Molecular Biology, School of Biological Sciences, University of Extremadura, Badajoz, Spain
    Mov Disord 24:1910-5. 2009
    ..18, 95% CI 1.01-1.38). These results suggest that DRD3 genotype and the variant DRD3Gly allelic variant is associated with the risk for and age at onset of ET, and with the risk for voice tremor, in Caucasian Spanish people...
  10. ncbi request reprint MAPT gene rs1052553 variant is not associated with the risk for multiple sclerosis
    Jose A G Agundez
    Department of Pharmacology, University of Extremadura, Caceres, Spain
    Hum Immunol 74:1705-8. 2013
    ..The aim of this study was to investigate a possible influence of the SNP rs1052553 in the MAPT gene in the risk for relapsing bout onset (relapsing-remitting and secondary progressive) MS...
  11. ncbi request reprint Glutathione S-transferases mu 1, theta 1, pi 1, alpha 1 and mu 3 genetic polymorphisms and the risk of colorectal and gastric cancers in humans
    Carmen Martinez
    Department of Pharmacology and Psychiatry, University of Extremadura, Badajoz, Spain
    Pharmacogenomics 7:711-8. 2006
    ..This study aimed to elucidate the influence of several GST polymorphisms on colorectal and gastric cancer risk...
  12. ncbi request reprint Changes at the CYP2C locus and disruption of CYP2C8/9 linkage disequilibrium in patients with essential tremor
    Carmen Martinez
    Department of Pharmacology and Psychiatry, Medical School, University of Extremadura, Badajoz, and Department of Medicine Neurology, Principe de Asturias Hospital, Alcala de Henares, Madrid, Spain
    Neuromolecular Med 9:195-204. 2007
    ..0001). These findings were independent of gender, age, age of onset, or clinical symptoms. These results suggest that alterations at the CYP2C gene locus are associated with the risk for ET...
  13. ncbi request reprint Glutathione S-transferase M1 and T1 genetic polymorphisms are not related to the risk of hepatocellular carcinoma: a study in the Spanish population
    Jose M Ladero
    Department of Gastroenterology, Hospital Clinico San Carlos, Complutense University, Madrid, Spain
    Eur J Cancer 42:73-7. 2006
    ..In conclusion, polymorphisms in GSTM1 and GSTT1 genes are not related to the incidence of HCC in a high-risk Spanish population...
  14. pmc Genetic predisposition to acute gastrointestinal bleeding after NSAIDs use
    Carmen Martinez
    Department of Pharmacology, Medical School, University of Extremadura, Badajoz, Spain
    Br J Pharmacol 141:205-8. 2004
    ..5 for heterozygous and 3.7 for homozygous carriers of mutations (P<0.015), suggesting that the inherited impairment of CYP2C9 activity increases the risk for severe adverse drug reactions after NSAIDs use...
  15. ncbi request reprint Alcohol dehydrogenase 2 genotype and risk for migraine
    Elena Garcia-Martin
    Department of Biochemistry and Molecular Biology, School of Biological Sciences, University of Extremadura
    Headache 50:85-91. 2010
    ..The aim of this study was to investigate the possible association between ADH2 polymorphism and the risk for migraine and for triggering migraine attacks...
  16. doi request reprint No association of the SLC1A2 rs3794087 allele with risk for essential tremor in the Spanish population
    Elena Garcia-Martin
    Departments of aBiochemistry and Molecular Biology bPharmacology, University of Extremadura, Cáceres cDepartment of Pharmacology, University of Extremadura, Badajoz dSection of Neurology, University Hospital of Sureste eDepartment of Medicine Neurology, Hospital Principe de Asturias, University of Alcalá fService of Neurology, Hospital Doce de Octubre, Department of Medicine, University Complutense gCenter for Biomedical Investigation, Net of Neurodegenerative Diseases CIBERNED, Instituto de Salud Carlos III, Madrid hNeurogenetics Laboratory, Division of Neurosciences, Center for Applied Medical Research, Universidad de Navarra iDepartment of Neurology, University Clinic of Navarra, University of Navarra School of Medicine, Pamplona jDepartment of Neurology, University Hospital of Salamanca, Salamanca, Spain
    Pharmacogenet Genomics 23:587-90. 2013
    ..We tried to replicate this association in a White Spanish population...
  17. pmc Vitamin D3 receptor ( VDR ) gene rs2228570 (Fok1) and rs731236 (Taq1) variants are not associated with the risk for multiple sclerosis: results of a new study and a meta-analysis
    Elena Garcia-Martin
    Department of Biochemistry and Molecular Biology, University of Extremadura, Caceres, Spain
    PLoS ONE 8:e65487. 2013
    ..Several studies suggested an interaction between some SNPs in the VDR gene and HLADRB1*1501 in the risk for MS...
  18. ncbi request reprint Alcohol dehydrogenase 2 genotype and allelic variants are not associated with the risk for essential tremor
    Carmen Martinez
    Department of Pharmacology and Psychiatry, Medical School, University of Extremadura, Badajoz, Spain
    Clin Neuropharmacol 30:196-200. 2007
    ..To investigate the possible association between alcohol dehydrogenase 1B, beta-polypeptide (ADH2) genotype and allelic variants and the risk for developing essential tremor (ET)...
  19. doi request reprint Paraoxonase 1 polymorphisms are not related with the risk for multiple sclerosis
    Carmen Martinez
    Department of Pharmacology and Psychiatry, Medical School, University of Extremadura, Badajoz, Spain
    Neuromolecular Med 12:217-23. 2010
    ..96 (0.73-1.26) and 1.01 (0.76-1.35), respectively. The results of the present study suggest that PON1 polymorphism is not related with the risk for multiple sclerosis in our population...
  20. doi request reprint Gamma-aminobutyric acid (GABA) receptor rho (GABRR) polymorphisms and risk for essential tremor
    Elena Garcia-Martin
    Department of Biochemistry and Molecular Biology, University of Extremadura, Badajoz, Spain
    J Neurol 258:203-11. 2011
    ..These data suggest that the single nucleotide polymorphisms studied in the GABBR genes are not related to the risk for ET...
  21. ncbi request reprint GSTT1 and GSTM1 null genotypes may facilitate hepatitis C virus infection becoming chronic
    Carmen Martinez
    Department of Pharmacology and Psychiatry, University of Extremadura, Badajoz, Spain
    J Infect Dis 195:1320-3. 2007
    ..02-2.35]; P=.032) null genotypes and of double-null haplotypes (OR, 3.65 [95% CI, 1.98-6.75]; P<.001). The GSTT1 null genotype, particularly if associated with the GSTM1 null genotype, may facilitate HCV infection becoming chronic...
  22. pmc The effect of the cytochrome P450 CYP2C8 polymorphism on the disposition of (R)-ibuprofen enantiomer in healthy subjects
    Carmen Martinez
    Department of Pharmacology, Medical School, University of Extremadura, Avda de Elvas s n, E 06071 Badajoz, Spain
    Br J Clin Pharmacol 59:62-9. 2005
    ..To study the effect of CYP2C8*3, the most common CYP2C8 variant allele on the dis-position of (R)-ibuprofen and the association of CYP2C8*3 with variant CYP2C9 alleles...
  23. ncbi request reprint A polymorphism located at an ATG transcription start site of the heme oxygenase-2 gene is associated with classical Parkinson's disease
    Pedro Ayuso
    Department of Biochemistry, Molecular Biology and Genetics, University of Extremadura, Badajoz, Spain
    Pharmacogenet Genomics 21:565-71. 2011
    ..Heme oxygenase 2 (HMOX2) catalyzes the cleavage of the heme ring to form biliverdin with release of iron and carbon monoxide. This study aims to analyze variations in the HMOX2 gene in patients with PD...
  24. ncbi request reprint Nonsynonymous polymorphisms of histamine-metabolising enzymes in patients with Parkinson's disease
    Jose A G Agundez
    Department of Pharmacology and Psychiatry, Medical School, University of Extremadura, Badajoz, Spain
    Neuromolecular Med 10:10-6. 2008
    ..To analyze genetically based impairment in histamine-metabolising enzymes in patients with Parkinson's disease (PD)...
  25. doi request reprint Gamma-aminobutyric acid GABRA4, GABRE, and GABRQ receptor polymorphisms and risk for essential tremor
    Elena Garcia-Martin
    Departments of Biochemistry and Molecular Biology, University of Extremadura, Badajoz
    Pharmacogenet Genomics 21:436-9. 2011
    ..32, 95% confidence interval=0.26-4.3, P=0.007, Pc=0.021). The results of this study suggest that the single nucleotide polymorphisms studied in the GABRA4, GABRE, and GABRQ genes are not related to the risk for familial ET...
  26. pmc Influence of vitamin D-related gene polymorphisms (CYP27B and VDR) on the response to interferon/ribavirin therapy in chronic hepatitis C
    Elena Garcia-Martin
    Department of Biochemistry and Molecular Biology, University of Extremadura, Caceres, Spain
    PLoS ONE 8:e74764. 2013
    ..This study was performed to assess the putative influence of polymorphisms in vitamin D-related genes on the response to antiviral therapy in patients with chronic hepatitis C (CHC)...
  27. doi request reprint Analysis of a non-synonymous single nucleotide polymorphism of the human diamine oxidase gene (ref. SNP ID: rs1049793) in patients with Crohn's disease
    Natalia López Palacios
    Service of Gastroenterology, Hospital Clinico San Carlos, Complutense University, Madrid, Spain
    Scand J Gastroenterol 44:1207-12. 2009
    ..To analyse the possible influence of a non-synonymous single nucleotide polymorphism (SNP) of the histamine-degrading enzyme diamine oxidase (DAO) on genetic susceptibility to Crohn's disease (CD)...
  28. ncbi request reprint Interindividual variability in ibuprofen pharmacokinetics is related to interaction of cytochrome P450 2C8 and 2C9 amino acid polymorphisms
    Elena Garcia-Martin
    Department of Biochemistry and Molecular Biology and Genetics, School of Biological Sciences, University of Extremadura, Badajoz, Spain
    Clin Pharmacol Ther 76:119-27. 2004
    ..Our objective was to identify genetic factors related to interindividual variability in the pharmacokinetics of ibuprofen and its enantiomers...
  29. ncbi request reprint Influence of cytochrome P450 CYP2C9 genotypes in lung cancer risk
    Elena Garcia-Martin
    Department of Biochemistry, School of Biological Sciences, University of Extremadura, Avda de Elvas s n, Badajoz, Spain
    Cancer Lett 180:41-6. 2002
    ..Association between CYP2C9 polymorphism and lung cancer risk was not identified in this study...
  30. pmc H1-MAPT and the risk for familial essential tremor
    Elena Garcia-Martin
    Department of Biochemistry and Molecular Biology, Universidad de Extremadura, Caceres, Spain
    PLoS ONE 7:e41581. 2012
    ..Our study suggests that the MAPT H1 rs1052553 is not associated with the risk for developing familial ET in the Spanish population...
  31. doi request reprint Paraoxonase 1 (PON1) polymorphisms and risk for migraine
    Elena Garcia-Martin
    Department of Biochemistry and Molecular Biology, School of Biological Sciences, University of Extremadura, Badajoz, Spain
    J Neurol 257:1482-5. 2010
    ....
  32. ncbi request reprint Variability in histamine receptor genes HRH1, HRH2 and HRH4 in patients with hypersensitivity to NSAIDs
    Pedro Ayuso
    Departamento de Bioquimica y Biologia Molecular y Genetica, Universidad de Extremadura, Avda de la Universidad s n 10071 Cáceres, Spain
    Pharmacogenomics 14:1871-8. 2013
    ..Genetic variations in histamine receptors (HRH) may influence the expression of allergic diseases. This study analyzes the association between HRH variants and NSAID hypersensitivity reactions...
  33. ncbi request reprint MAPT1 gene rs1052553 variant is unrelated with the risk for restless legs syndrome
    Angela Roco
    Department of Pharmacology, University of Extremadura, Caceres, Spain
    J Neural Transm 120:463-7. 2013
    ..The results of the present study suggest that the SNP rs1052553 is not related with the risk for RLS...
  34. pmc Severity of ulcerative colitis is associated with a polymorphism at diamine oxidase gene but not at histamine N-methyltransferase gene
    Elena Garcia-Martin
    Department of Pharmacology, Medical School, University of Extremadura, Avda de Elvas s n, E 06071 Badajoz, Spain
    World J Gastroenterol 12:615-20. 2006
    ..To analyse the role of two common polymorphisms in genes coding for histamine metabolising enzymes as it relates to the risk to develop ulcerative colitis (UC) and the clinical course of these patients...
  35. pmc Genetic variability in CYP3A4 and CYP3A5 in primary liver, gastric and colorectal cancer patients
    Guillermo Gervasini
    Department of Pharmacology and Psychiatry, University of Extremadura, Badajoz, Spain
    BMC Cancer 7:118. 2007
    ..This study aims to examine associations between common CYP3A4 and CYP3A5 polymorphisms and digestive cancer risk...
  36. doi request reprint Histamine-N-methyl transferase polymorphism and risk for migraine
    Elena Garcia-Martin
    Department of Biochemistry and Molecular Biology, School of Biological Sciences, University of Extremadura, Madrid, Spain
    Headache 48:1343-8. 2008
    ..The aim of this study was to investigate the possible association between HNMT polymorphism and the risk for migraine...
  37. doi request reprint Polymorphism of the TLR4 gene reduces the risk of hepatitis C virus-induced hepatocellular carcinoma
    Jose A Agundez
    Department of Pharmacology, Medical School, University of Extremadura, Badajoz, Spain
    Oncology 82:35-40. 2012
    ..This is a single-centre-based study designed to analyse the distribution of several TLR4 gene single nucleotide polymorphisms in healthy controls and in patients chronically infected with HCV, with and without HCC...
  38. doi request reprint Interaction of CYP2C8 and CYP2C9 genotypes modifies the risk for nonsteroidal anti-inflammatory drugs-related acute gastrointestinal bleeding
    Gerardo Blanco
    Department of Pharmacology, Medical School, University of Extremadura, Service of Surgery, University Hospital Infanta Cristina, Badajoz, Spain
    Pharmacogenet Genomics 18:37-43. 2008
    ..To analyze whether gene variants leading to impaired drug metabolism are related with acute gastrointestinal bleeding after nonsteroidal anti-inflammatory drugs (NSAID) use...
  39. ncbi request reprint CYP3A4 variant alleles in white individuals with low CYP3A4 enzyme activity
    Elena Garcia-Martin
    Department of Biochemistry, School of Biological Sciences, University of Extremadura, Badajoz, Spain
    Clin Pharmacol Ther 71:196-204. 2002
    ..Our objective was to evaluate the presence of CYP3A4 gene variants in white individuals with low CYP3A4 enzyme activity...
  40. ncbi request reprint Interethnic and intraethnic variability of CYP2C8 and CYP2C9 polymorphisms in healthy individuals
    Elena Garcia-Martin
    Department of Biochemistry and Molecular Biology, School of Sciences, University of Extremadura, Badajoz, Spain
    Mol Diagn Ther 10:29-40. 2006
    ....
  41. ncbi request reprint Acquired resistance to the anticancer drug paclitaxel is associated with induction of cytochrome P450 2C8
    Elena Garcia-Martin
    University of Extremadura, Biochemistry and Molecular Biology and Genetics, Avda de Elvas s n, 06071, Badajoz, Spain
    Pharmacogenomics 7:575-85. 2006
    ..The aim of this study was to evaluate whether changes in the expression levels of genes coding for such enzymes are related to anticancer drug resistance after long-term exposure to the drug...
  42. pmc Relation of IL28B gene polymorphism with biochemical and histological features in hepatitis C virus-induced liver disease
    Jose A Agundez
    Department of Pharmacology, University of Extremadura, Caceres, Spain
    PLoS ONE 7:e37998. 2012
    ..Our aim was to study the influence of IL28B rs12979860 gene polymorphism on the biochemistry and pathology of HCV-induced disease in the clinical course from mild chronic hepatitis C to hepatocellular carcinoma...
  43. ncbi request reprint Pharmacogenomics in aspirin intolerance
    Jose A G Agundez
    Department of Pharmacology, Medical School University of Extremadura, Avda de Elvas s n, Badajoz, Spain
    Curr Drug Metab 10:998-1008. 2009
    ..Combined studies for the above mentioned polymorphisms and those corresponding to other genes related to aspirin intolerance will provide excellent tools to identify individuals with a high risk to develop intolerance to aspirin...
  44. ncbi request reprint Glutathione S-transferases pi 1, alpha 1 and M3 genetic polymorphisms and the risk of hepatocellular carcinoma in humans
    Jose M Ladero
    1Universidad Complutense, Service of Gastroenterology, Hospital Clinico San Carlos, c Martin Lagos s n, 28040 Madrid Spain
    Pharmacogenomics 8:895-9. 2007
    ..Polymorphisms affecting the genes encoding these enzymes may modify their ability to neutralize carcinogens. Our aim was to investigate whether these polymorphisms affect the risk of developing hepatocellular carcinoma in humans...
  45. doi request reprint Anti-Parkinson's disease drugs and pharmacogenetic considerations
    Jose A G Agundez
    University of Extremadura, Department of Pharmacology, Avda de la Universidad s n, E 10071, Caceres, Spain
    Expert Opin Drug Metab Toxicol 9:859-74. 2013
    ..These biomarkers are then used as surrogate endpoints. This review analyzes potential genetic biomarkers which can be used to improve anti-Parkinson's disease therapy...
  46. ncbi request reprint Genetic variability of human diamine oxidase: occurrence of three nonsynonymous polymorphisms and study of their effect on serum enzyme activity
    Pedro Ayuso
    Department of Biochemistry and Molecular Biology and Genetics, School of Biological Sciences, Medical School, University of Extremadura, Badajoz, Spain
    Pharmacogenet Genomics 17:687-93. 2007
    ..To analyze the occurrence and the functional effects of nonsynonymous single nucleotide polymorphisms in the human diamine oxidase (ABP1) gene...
  47. doi request reprint The nonsynonymous Thr105Ile polymorphism of the histamine N-methyltransferase is associated to the risk of developing essential tremor
    Maria C Ledesma
    Department of Pharmacology and Psychiatry, Medical School, University of Extremadura, Badajoz, Spain
    Neuromolecular Med 10:356-61. 2008
    ..We analyzed in patients with essential tremor (ET) the Thr105Ile polymorphism of the Histamine N-methyltransferase (HNMT) enzyme that is associated to Parkinson's disease (PD) risk...
  48. pmc Two common nonsynonymous paraoxonase 1 (PON1) gene polymorphisms and brain astrocytoma and meningioma
    Carmen Martinez
    Department of Biochemistry and Molecular Biology and Genetics, University of Extremadura, Avda de Elvas s n, 06071, Badajoz, Spain
    BMC Neurol 10:71. 2010
    ..3. Aiming to identify genetic variations related to the risk of developing brain tumors, we investigated the putative association between common nonsynonymous PON1 polymorphisms and the risk of developing astrocytoma and meningioma...
  49. doi request reprint Assessment of nonsteroidal anti-inflammatory drug-induced hepatotoxicity
    José Ag Agúndez
    Department of Pharmacology, Medical School University of Extremadura, Avda de Elvas s n, E 06071, Badajoz, Spain
    Expert Opin Drug Metab Toxicol 7:817-28. 2011
    ..The assessment of NSAID-induced hepatotoxicity, presently based on clinical and analytical biomarkers, is critical for early diagnosis and immediate withdrawal of the causing drug...
  50. ncbi request reprint SLC1A2 rs3794087 variant and risk for migraine
    Elena Garcia-Martin
    Department of Biochemistry and Molecular Biology, University of Extremadura, Caceres, Spain
    J Neurol Sci 338:92-5. 2014
    ....
  51. ncbi request reprint Unraveling ambiguous NAT2 genotyping data
    Jose A G Agundez
    Department of Pharmacology, Medical School, University of Extremadura, Badajoz, Spain
    Clin Chem 54:1390-4. 2008
    ..1.1, a statistical program for haplotype reconstruction, to clarify this ambiguity and classify individuals according to their acetylation status...
  52. pmc The differential effect of NAT2 variant alleles permits refinement in phenotype inference and identifies a very slow acetylation genotype
    Jhon D Ruiz
    Department of Pharmacology, Medical School, University of Extremadura, Badajoz and Cáceres, Spain
    PLoS ONE 7:e44629. 2012
    ..The refinement in phenotype prediction may help to identify risks associated to phenotype subcategories, and warrants the re-analysis of previous studies that may have overlooked phenotype subcategory-specific risks...
  53. doi request reprint Variability in ethanol biodisposition in whites is modulated by polymorphisms in the ADH1B and ADH1C genes
    Carmen Martinez
    Department of Pharmacology, Medical School, University of Extremadura, Badajoz, Spain
    Hepatology 51:491-500. 2010
    ..Most individuals had significant delays in reaction and motor times at alcohol blood concentrations under 500 mg/L, which are the driving limits for most countries...
  54. ncbi request reprint Polymorphic drug metabolism in anaesthesia
    Juan G Restrepo
    Department of Pharmacology, Medical School University of Extremadura, Avda de Elvas s n, E 06071, Badajoz, Spain
    Curr Drug Metab 10:236-46. 2009
    ..Based on functional relevance and allele frequencies, we identify the most promising targets for the clinical use of pharmacogenomic techniques in anaesthesia to prevent altered pharmacokinetics or adverse drug effects...
  55. ncbi request reprint COMT gene and risk for Parkinson's disease: a systematic review and meta-analysis
    Félix J Jiménez-Jiménez
    aSection of Neurology, Hospital Universitario del Sureste, Arganda del Rey, Madrid, Spain bDepartment of Medicine Neurology, Hospital Principe de Asturias, Universidad de Alcala, Alcala de Henares, Madrid cDepartment of Biochemistry and Molecular Biology dDepartment of Pharmacology, University of Extremadura, Caceres, Spain
    Pharmacogenet Genomics 24:331-9. 2014
    ..We also reviewed the possible relationship of COMT SNPs with clinical, neuropharmacological, neurochemical, and neuroimaging features of PD...
  56. ncbi request reprint Genetically based impairment in CYP2C8- and CYP2C9-dependent NSAID metabolism as a risk factor for gastrointestinal bleeding: is a combination of pharmacogenomics and metabolomics required to improve personalized medicine?
    Jose A G Agundez
    Department of Pharmacology, University of Extremadura, Medical School, Badajoz, Spain
    Expert Opin Drug Metab Toxicol 5:607-20. 2009
    ....
  57. ncbi request reprint Inhibition of oxidative stress produced by plasma membrane NADH oxidase delays low-potassium-induced apoptosis of cerebellar granule cells
    Francisco Javier Martin-Romero
    Departamento de Bioquimica y Biologia Molecular y Genetica, Facultad de Ciencias and Escuela de Ingenierías Agrarias, Universidad de Extremadura, Spain
    J Neurochem 82:705-15. 2002
    ..5)-value (4-5 mm 4-HQ). The efficient blockade of CGC apoptosis by addition of superoxide dismutase to the medium further supports the neurotoxic role of *O2- overproduction by the plasma membrane ascorbate-dependent NADH oxidase...
  58. ncbi request reprint Gene variants and haplotypes modifying transcription factor binding sites in the human cyclooxygenase 1 and 2 (PTGS1 and PTGS2) genes
    Jose A G Agundez
    Department of Pharmacology, University of Extremadura, Avda de la Universidad s n, 10071, Caceres, Spain
    Curr Drug Metab 15:182-95. 2014
    ..This information can be useful to identify potential genetic targets for studies related to COX enzymes. ..