Santos Fustero


Affiliation: University of Valencia
Country: Spain


  1. Mei H, Liu J, Fustero S, Román R, Ruzziconi R, Soloshonok V, et al. Chemistry of detrifluoroacetylatively in situ generated fluoro-enolates. Org Biomol Chem. 2019;17:762-775 pubmed publisher
    ..The innovative facets of this unconventional methodology and its synthetic generality for the preparation of fluorine-containing compounds of high medicinal value are highlighted. ..
  2. Fustero S, Moscardó J, Sánchez Roselló M, Rodríguez E, Barrio P. Tandem nucleophilic addition-intramolecular aza-Michael reaction: facile synthesis of chiral fluorinated isoindolines. Org Lett. 2010;12:5494-7 pubmed publisher
    ..In the majority of all cases, the products are formed as single isomers. ..
  3. Fustero S, Miró J, Sánchez Roselló M, Del Pozo C. Tandem gold self-relay catalysis for the synthesis of 2,3-dihydropyridin-4(1 H)-ones: combination of σ and π Lewis acid properties of gold salts. Chemistry. 2014;20:14126-31 pubmed publisher
    ..The asymmetric version was performed by generating the starting materials from the corresponding sulfinylimines. ..
  4. Catalán S, Munoz S, Fustero S. Unique reactivity of fluorinated molecules with transition metals. Chimia (Aarau). 2014;68:382-409 pubmed publisher
    ..Given the importance of the selective introduction of fluorine atoms into organic molecules and the effectiveness of transition metals in C-C and C-heteroatom bond formation, this review represents an interesting read for this aim. ..
  5. Fustero S, Román R, Sanz Cervera J, Simón Fuentes A, Cuñat A, Villanova S, et al. Improved regioselectivity in pyrazole formation through the use of fluorinated alcohols as solvents: synthesis and biological activity of fluorinated tebufenpyrad analogs. J Org Chem. 2008;73:3523-9 pubmed publisher
  6. Fustero S, Sánchez Roselló M, Báez C, Del Pozo C, García Ruano J, Alemán J, et al. Asymmetric synthesis of quaternary ?-amino acid derivatives and their fluorinated analogues. Amino Acids. 2011;41:559-73 pubmed publisher
    ..Synthetic practicality of this method is demonstrated by short (two-steps) and convenient preparation of 2-(trifluoromethyl)indoline-2-carboxylates. ..
  7. Barrio P, Ibáñez I, Herrera L, Román R, Catalán S, Fustero S. Asymmetric Synthesis of Fluorinated Isoindolinones through Palladium-Catalyzed Carbonylative Amination of Enantioenriched Benzylic Carbamates. Chemistry. 2015;21:11579-84 pubmed publisher
    ..This mechanistic rationale enabled the minimization of this partial racemization by fine-tuning the pKa of the base. ..
  8. Mateu N, Ciordia M, Delgado O, Sánchez Roselló M, Trabanco A, Van Gool M, et al. A Versatile Approach to CF3 -Containing 2-Pyrrolidones by Tandem Michael Addition-Cyclization: Exemplification in the Synthesis of Amidine Class BACE1 Inhibitors. Chemistry. 2015;21:11719-26 pubmed publisher
    ..This work constitutes an example of selective fluorination as a valid strategy for the modulation of physicochemical and biological properties of lead compounds in drug discovery. ..
  9. Miró J, Del Pozo C, Toste F, Fustero S. Enantioselective Palladium-Catalyzed Oxidative ?,?-Fluoroarylation of ?,?-Unsaturated Carbonyl Derivatives. Angew Chem Int Ed Engl. 2016;55:9045-9 pubmed publisher
    ..The developed methodology establishes a general, modular, and step-economical approach to the stereoselective ?-fluorination of ?,?-unsaturated systems. ..

More Information


  1. Remete A, Nonn M, Fustero S, Fulop F, Kiss L. A Stereocontrolled Protocol to Highly Functionalized Fluorinated Scaffolds through a Fluoride Opening of Oxiranes. Molecules. 2016;21: pubmed
  2. Fustero S, Román R, Sanz Cervera J, Simón Fuentes A, Bueno J, Villanova S. Synthesis of new fluorinated Tebufenpyrad analogs with acaricidal activity through regioselective pyrazole formation. J Org Chem. 2008;73:8545-52 pubmed publisher
    ..These compounds display a strong acaricidal activity that is either comparable to or better than that of the commercial compound...