Research Topics
Genomes and Genes | Pablo EngelSummaryAffiliation: University of Barcelona Country: Spain Publications
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Publications
The adaptor 3BP2 activates CD244-mediated cytotoxicity in PKC- and SAP-dependent mechanismsIfigenia Saborit-Villarroya
Immunoreceptors group, Institut d Investigació August Pi i Sunyer IDIBAPS, Immunology Unit, Department of Cellular Biology and Pathology, Medical School, University of Barcelona, Barcelona, Spain
Mol Immunol 45:3446-53. 2008..In conclusion, our data show that 3BP2 acts downstream of SAP, increases CD244 phosphorylation and links the receptor with PI3K, Vav, PLC gamma, and PKC downstream events in order to achieve maximum NK killing function...
The SAP and SLAM families in immune responses and X-linked lymphoproliferative diseasePablo Engel
Immunology Unit, Department of Cellular Biology and Pathology, Medical School, University of Barcelona, Barcelona 08036, Spain
Nat Rev Immunol 3:813-21. 2003..In this review, we discuss recent findings on the structure and function of proteins of the SAP and SLAM families...- Mouse CD84 is a pan-leukocyte cell-surface molecule that modulates LPS-induced cytokine secretion by macrophagesJordi Sintes
Immunology Unit, Department of Cell Biology, Immunology and Neurosciences, Medical School, University of Barcelona, Institute of Biomedical Research August Pi Sunyer IDIBAPS, Spain
J Leukoc Biol 88:687-97. 2010..Taken together, these results show that mouse CD84 is a pan-leukocyte receptor, able to modulate signaling pathways downstream of TLR4, and regulates macrophage cell-fate decisions and effector functions... - Expression profiles of novel cell surface molecules on B-cell subsets and plasma cells as analyzed by flow cytometryLaia Llinàs
Immunology Unit, Department of Cell Biology, Immunology and Neurosciences, Medical School, University of Barcelona, Institut d Investigacions Biomediques August Pi i Sunyer, Barcelona, Spain
Immunol Lett 134:113-21. 2011.... - CD229 (Ly9) lymphocyte cell surface receptor interacts homophilically through its N-terminal domain and relocalizes to the immunological synapseXavier Romero
Immunology Unit, Department of Cellular Biology and Pathology, Medical School, University of Barcelona, Spain
J Immunol 174:7033-42. 2005..Confocal microscopy image analysis revealed relocalization of CD229 to the contact area of T and B cells during Ag-dependent immune synapse formation. Thus, CD229 is its own ligand and participates in the immunological synapse... - P-selectin mediates leukocyte rolling in concanavalin-A-induced hepatitisSandra March
Immunology Unit, Department of Cellular Biology and Pathology, Medical School, University of Barcelona, Villaroel 170, Barcelona, Spain
Liver Int 25:1053-60. 2005..CONCLUSION: The results of this intravital microscopy study clearly demonstrate that P-selectin is involved in the initial leukocyte rolling that leads to the development of Con-A-induced liver injury... - Characterization of antibodies submitted to the B cell section of the 8th Human Leukocyte Differentiation Antigens Workshop by flow cytometry and immunohistochemistryMiriam Vidal-Laliena
Immunology Unit, Department of Cellular Biology and Pathology, Medical School, University of Barcelona, Institut d Investigacions Biomediques August Pi i Sunyer, Casanova 143, Barcelona E 08036, Spain
Cell Immunol 236:6-16. 2005..Three of these new CDs, CD267, CD269, and CD307 presented a B cell-restricted expression pattern. MAbs against these novel cell-surface molecules may offer new tools for research, diagnosis, and therapy... - The cell surface expression of SAP-binding receptor CD229 is regulated via its interaction with clathrin-associated adaptor complex 2 (AP-2)Juana M Del Valle
Department of Cellular Biology and Pathology, University of Barcelona School of Medicine, Institut d Investigacions Biomediques August Pi i Sunyer, Barcelona E 08036, Spain
J Biol Chem 278:17430-7. 2003..These data suggest that CD229 cell surface expression on lymphocytes surface is strongly and differentially regulated within the CD150 family members... 
Cutting Edge: Ly9 (CD229), a SLAM family receptor, negatively regulates the development of thymic innate memory-like CD8+ T and invariant NKT cellsJordi Sintes
Immunology Unit, Department of Cell Biology, Immunology, and Neurosciences, Medical School, University of Barcelona, 08036 Barcelona, Spain
J Immunol 190:21-6. 2013..Thus, Ly9 plays a unique role as an inhibitory cell surface receptor regulating the size of the thymic innate CD8(+) T cell pool and the development of invariant NKT cells...- Expression of SLAM (CD150) cell-surface receptors on human B-cell subsets: from pro-B to plasma cellsJose de Salort
Immunology Unit, Department of Cell Biology, Immunology and Neurosciences, Medical School, University of Barcelona, Institut d Investigacions Biomediques August Pi i Sunyer IDIBAPS, C Casanova 143, Barcelona, Spain
Immunol Lett 134:129-36. 2011..Such heterogeneous expression patterns suggest that SLAM molecules play an essential and non-redundant role in the control of humoral immune responses... - Differential expression of CD150 (SLAM) family receptors by human hematopoietic stem and progenitor cellsJordi Sintes
Department of Cellular Biology and Pathology, Medical School, University of Barcelona, Barcelona, Spain
Exp Hematol 36:1199-204. 2008..The goal of the present study is to analyze the expression patterns of the CD150 receptors CD48, CD84, CD150 (SLAM), CD229 (Ly9), and CD244 (2B4) on the different sources of human hematopoietic stem and progenitor cells... - Identification and functional characterization of the hepatic stellate cell CD38 cell surface moleculeSandra March
Immunology Unit, Department of Cellular Biology and Pathology, Medical School, University of Barcelona, Barcelona, Spain
Am J Pathol 170:176-87. 2007..Collectively, our data suggest that CD38 can act as a regulator of HSC activation and effector functions... - Viral immunomodulatory proteins: usurping host genes as a survival strategyPablo Engel
Department of Cell Biology, Immunology and Neurosciences, Medical School, University of Barcelona, Barcelona, Spain
Adv Exp Med Biol 738:256-76. 2012..A systematic study of these genes, in addition to unraveling specific virus-host interactions, may supply valuable tools to dissect the molecular basis of immune responses... - Human cytomegalovirus UL7, a homologue of the SLAM-family receptor CD229, impairs cytokine productionPablo Engel
Department of Cell Biology, Immunology, and Neurosciences, Medical School, University of Barcelona, Barcelona, Spain
Immunol Cell Biol 89:753-66. 2011..These results enhance our understanding of those HCMV-encoded molecules involved in sustaining the balance between HCMV and the host immune system... - Identification and characterization of a novel spliced variant that encodes human soluble tumor necrosis factor receptor 2Begoña Laínez
Immunology Unit, Department of Cellular Biology and Pathology, Medical School, University of Barcelona, Institut d Investigacions Biomediques August Pi i Sunyer, 08036 Barcelona, Spain
Int Immunol 16:169-77. 2004..Our data show that sTNFR2 generated by alternative splicing can be found in sera of healthy individuals, at increased levels in patients with sepsis and at high concentrations in rheumatoid arthritis patients... - Towards a comprehensive human cell-surface immunome databaseM Carmen Díaz-Ramos
Institut d investigacions Biomèdiques Agust Pi i Sunyer IDIBAPS, Dept of Cell Biology, Immunology and Neurosciences, University of Barcelona, Spain
Immunol Lett 134:183-7. 2011.... - New B-cell CD moleculesJessica Matesanz-Isabel
Immunology Unit, Department of Cell Biology, Immunology and Neurosciences, Medical School, University of Barcelona, C Casanova 143, Institut d Investigacions Biomediques August Pi i Sunyer, Barcelona, Spain
Immunol Lett 134:104-12. 2011..The availability of monoclonal antibodies directed against novel B cell-surface molecules will have broad implications not only for B-cell biology, but also for the development of new diagnostic and therapeutic tools... - Therapeutic targeting of B cells for rheumatic autoimmune diseasesPablo Engel
Immunology Unit, Department of Cell Biology, Immunology and Neuroscience, Faculty of Medicine, University of Barcelona, Barcelona, Spain
Pharmacol Rev 63:127-56. 2011.... - Characterization of platelet and soluble-porcine P-selectin (CD62P)Anna Massaguer
Department of Cellular Biology and Pathology, Immunology Unit, Medical School, University of Barcelona, Barcelona, Spain
Vet Immunol Immunopathol 96:169-81. 2003..These data suggest that porcine P-selectin is a suitable marker for inflammation and that the mechanism involved in the generation of circulating P-selectin is not proteolytic release... - Mouse novel Ly9: a new member of the expanding CD150 (SLAM) family of leukocyte cell-surface receptorsVictoria Tovar
Institut d Investigacions Biomediques August Pi i Sunyer, Barcelona, Spain
Immunogenetics 54:394-402. 2002..Taken together, these data indicate that mouse novel Ly9 is a new member of the expanding CD150 family of cell surface receptors... - Identification of Grb2 as a novel binding partner of the signaling lymphocytic activation molecule-associated protein binding receptor CD229Margarita Martin
Unitat d Immunologia, Institut d Investigacions Biomediques August Pi i Sunyer, Departament de Biologia Cellular i Anatomia Patologica, Facultat de Medicina, Universitat de Barcelona, Barcelona, Spain
J Immunol 174:5977-86. 2005..Altogether, the data suggest a model whereby CD229 ligation attenuates TCR signaling and Grb2 recruitment to CD229 controls its rate of internalization... - The SLAM and SAP gene families control innate and adaptive immune responsesSilvia Calpe
Division of Immunology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA
Adv Immunol 97:177-250. 2008..Here we discuss the current understanding of the structure and function of these recently discovered receptors and adapter molecules in the regulation of adaptive and innate immune responses... - The leukocyte receptor CD84 inhibits Fc epsilon RI-mediated signaling through homophilic interaction in transfected RBL-2H3 cellsIrene Oliver-Vila
Grup Immunoreceptors, Institut d Investigació August Pi i Sunyer, Department de Biologia Cellular i Anatomia Patologica, Facultat Medicina, Universitat de Barcelona, Barcelona, Spain
Mol Immunol 45:2138-49. 2008..These data suggest that CD84 may play a role in modulating Fc epsilon RI-mediated signaling in mast cells. Thus, CD84 could play a protective role against undesired allergic and inflammatory responses... - CD molecules 2006--human cell differentiation moleculesHeddy Zola
Child Health Research Institute and Adelaide University Discipline of Paediatrics, 72 King William Road, North Adelaide, South Australia 5006, Australia
J Immunol Methods 319:1-5. 2007..At that meeting the Council, acting as Nomenclature Committee, approved a number of new CD designations and changes to some pre-existing CD designations, which are summarized in this report... - The adaptor protein 3BP2 binds human CD244 and links this receptor to Vav signaling, ERK activation, and NK cell killingIfigenia Saborit-Villarroya
Unitat d Immunologia, Departament de Biologia Cellular i Anatomia Patologica, Facultat de Medicina, Universitat de Barcelona, Spain
J Immunol 175:4226-35. 2005..These results indicate that CD244-3BP2 association regulates cytolytic function but not IFN-gamma release, reinforcing the hypothesis that, in humans, CD244-mediated cytotoxicity and IFN-gamma release involve distinct NK pathways... - CD molecules 2005: human cell differentiation moleculesHeddy Zola
Child Health Research Institute, 72 King William Rd, North Adelaide 5006, South Australia, Australia
Blood 106:3123-6. 2005.... - Induction of tumor NK-cell immunity by anti-CD69 antibody therapyEnric Esplugues
, Universidad de Barcelona, Av Diagonal, 645 Barcelona 08028, Spain
Blood 105:4399-406. 2005..Modulation of the innate immune system with monoclonal antibodies to host CD69 thus provides a novel means to antagonize tumor growth and metastasis... - Enhanced antitumor immunity in mice deficient in CD69Enric Esplugues
Departmento de Fisiologia, Universidad de Barcelona, Barcelona 08080 Spain
J Exp Med 197:1093-106. 2003..These data unmask a novel role for CD69 as a negative regulator of anti-tumor responses and show the possibility of a novel approach for the therapy of tumors... - Shedding of TNF-alpha receptors, blood pressure, and insulin sensitivity in type 2 diabetes mellitusJose Manuel Fernandez-Real
Unitat de Diabetologia, Endocrinologia i Nutricio, University Hospital of Girona, 17001 Girona, Spain
Am J Physiol Endocrinol Metab 282:E952-9. 2002..Our findings suggest that insulin resistance and blood pressure are linked to altered shedding of TNF-alpha receptors in DM-2. The latter seems reversible and is not genetically determined...