Pablo Engel

Summary

Affiliation: University of Barcelona
Country: Spain

Publications

  1. doi request reprint The adaptor 3BP2 activates CD244-mediated cytotoxicity in PKC- and SAP-dependent mechanisms
    Ifigenia Saborit-Villarroya
    Immunoreceptors group, Institut d Investigació August Pi i Sunyer IDIBAPS, Immunology Unit, Department of Cellular Biology and Pathology, Medical School, University of Barcelona, Barcelona, Spain
    Mol Immunol 45:3446-53. 2008
  2. ncbi request reprint The SAP and SLAM families in immune responses and X-linked lymphoproliferative disease
    Pablo Engel
    Immunology Unit, Department of Cellular Biology and Pathology, Medical School, University of Barcelona, Barcelona 08036, Spain
    Nat Rev Immunol 3:813-21. 2003
  3. doi request reprint Mouse CD84 is a pan-leukocyte cell-surface molecule that modulates LPS-induced cytokine secretion by macrophages
    Jordi Sintes
    Immunology Unit, Department of Cell Biology, Immunology and Neurosciences, Medical School, University of Barcelona, Institute of Biomedical Research August Pi Sunyer IDIBAPS, Spain
    J Leukoc Biol 88:687-97. 2010
  4. doi request reprint Expression profiles of novel cell surface molecules on B-cell subsets and plasma cells as analyzed by flow cytometry
    Laia Llinàs
    Immunology Unit, Department of Cell Biology, Immunology and Neurosciences, Medical School, University of Barcelona, Institut d Investigacions Biomediques August Pi i Sunyer, Barcelona, Spain
    Immunol Lett 134:113-21. 2011
  5. ncbi request reprint CD229 (Ly9) lymphocyte cell surface receptor interacts homophilically through its N-terminal domain and relocalizes to the immunological synapse
    Xavier Romero
    Immunology Unit, Department of Cellular Biology and Pathology, Medical School, University of Barcelona, Spain
    J Immunol 174:7033-42. 2005
  6. ncbi request reprint P-selectin mediates leukocyte rolling in concanavalin-A-induced hepatitis
    Sandra March
    Immunology Unit, Department of Cellular Biology and Pathology, Medical School, University of Barcelona, Villaroel 170, Barcelona, Spain
    Liver Int 25:1053-60. 2005
  7. ncbi request reprint Characterization of antibodies submitted to the B cell section of the 8th Human Leukocyte Differentiation Antigens Workshop by flow cytometry and immunohistochemistry
    Miriam Vidal-Laliena
    Immunology Unit, Department of Cellular Biology and Pathology, Medical School, University of Barcelona, Institut d Investigacions Biomediques August Pi i Sunyer, Casanova 143, Barcelona E 08036, Spain
    Cell Immunol 236:6-16. 2005
  8. pmc Cutting Edge: Ly9 (CD229), a SLAM family receptor, negatively regulates the development of thymic innate memory-like CD8+ T and invariant NKT cells
    Jordi Sintes
    Immunology Unit, Department of Cell Biology, Immunology, and Neurosciences, Medical School, University of Barcelona, 08036 Barcelona, Spain
    J Immunol 190:21-6. 2013
  9. ncbi request reprint The cell surface expression of SAP-binding receptor CD229 is regulated via its interaction with clathrin-associated adaptor complex 2 (AP-2)
    Juana M Del Valle
    Department of Cellular Biology and Pathology, University of Barcelona School of Medicine, Institut d Investigacions Biomediques August Pi i Sunyer, Barcelona E 08036, Spain
    J Biol Chem 278:17430-7. 2003
  10. doi request reprint Expression of SLAM (CD150) cell-surface receptors on human B-cell subsets: from pro-B to plasma cells
    Jose de Salort
    Immunology Unit, Department of Cell Biology, Immunology and Neurosciences, Medical School, University of Barcelona, Institut d Investigacions Biomediques August Pi i Sunyer IDIBAPS, C Casanova 143, Barcelona, Spain
    Immunol Lett 134:129-36. 2011

Collaborators

Detail Information

Publications29

  1. doi request reprint The adaptor 3BP2 activates CD244-mediated cytotoxicity in PKC- and SAP-dependent mechanisms
    Ifigenia Saborit-Villarroya
    Immunoreceptors group, Institut d Investigació August Pi i Sunyer IDIBAPS, Immunology Unit, Department of Cellular Biology and Pathology, Medical School, University of Barcelona, Barcelona, Spain
    Mol Immunol 45:3446-53. 2008
    ..In conclusion, our data show that 3BP2 acts downstream of SAP, increases CD244 phosphorylation and links the receptor with PI3K, Vav, PLC gamma, and PKC downstream events in order to achieve maximum NK killing function...
  2. ncbi request reprint The SAP and SLAM families in immune responses and X-linked lymphoproliferative disease
    Pablo Engel
    Immunology Unit, Department of Cellular Biology and Pathology, Medical School, University of Barcelona, Barcelona 08036, Spain
    Nat Rev Immunol 3:813-21. 2003
    ..In this review, we discuss recent findings on the structure and function of proteins of the SAP and SLAM families...
  3. doi request reprint Mouse CD84 is a pan-leukocyte cell-surface molecule that modulates LPS-induced cytokine secretion by macrophages
    Jordi Sintes
    Immunology Unit, Department of Cell Biology, Immunology and Neurosciences, Medical School, University of Barcelona, Institute of Biomedical Research August Pi Sunyer IDIBAPS, Spain
    J Leukoc Biol 88:687-97. 2010
    ..Taken together, these results show that mouse CD84 is a pan-leukocyte receptor, able to modulate signaling pathways downstream of TLR4, and regulates macrophage cell-fate decisions and effector functions...
  4. doi request reprint Expression profiles of novel cell surface molecules on B-cell subsets and plasma cells as analyzed by flow cytometry
    Laia Llinàs
    Immunology Unit, Department of Cell Biology, Immunology and Neurosciences, Medical School, University of Barcelona, Institut d Investigacions Biomediques August Pi i Sunyer, Barcelona, Spain
    Immunol Lett 134:113-21. 2011
    ....
  5. ncbi request reprint CD229 (Ly9) lymphocyte cell surface receptor interacts homophilically through its N-terminal domain and relocalizes to the immunological synapse
    Xavier Romero
    Immunology Unit, Department of Cellular Biology and Pathology, Medical School, University of Barcelona, Spain
    J Immunol 174:7033-42. 2005
    ..Confocal microscopy image analysis revealed relocalization of CD229 to the contact area of T and B cells during Ag-dependent immune synapse formation. Thus, CD229 is its own ligand and participates in the immunological synapse...
  6. ncbi request reprint P-selectin mediates leukocyte rolling in concanavalin-A-induced hepatitis
    Sandra March
    Immunology Unit, Department of Cellular Biology and Pathology, Medical School, University of Barcelona, Villaroel 170, Barcelona, Spain
    Liver Int 25:1053-60. 2005
    ..The aim of the present study was to evaluate the role of P-selectin on leukocyte-endothelial interactions within the hepatic microvasculature in response to Con-A...
  7. ncbi request reprint Characterization of antibodies submitted to the B cell section of the 8th Human Leukocyte Differentiation Antigens Workshop by flow cytometry and immunohistochemistry
    Miriam Vidal-Laliena
    Immunology Unit, Department of Cellular Biology and Pathology, Medical School, University of Barcelona, Institut d Investigacions Biomediques August Pi i Sunyer, Casanova 143, Barcelona E 08036, Spain
    Cell Immunol 236:6-16. 2005
    ..Three of these new CDs, CD267, CD269, and CD307 presented a B cell-restricted expression pattern. MAbs against these novel cell-surface molecules may offer new tools for research, diagnosis, and therapy...
  8. pmc Cutting Edge: Ly9 (CD229), a SLAM family receptor, negatively regulates the development of thymic innate memory-like CD8+ T and invariant NKT cells
    Jordi Sintes
    Immunology Unit, Department of Cell Biology, Immunology, and Neurosciences, Medical School, University of Barcelona, 08036 Barcelona, Spain
    J Immunol 190:21-6. 2013
    ..Thus, Ly9 plays a unique role as an inhibitory cell surface receptor regulating the size of the thymic innate CD8(+) T cell pool and the development of invariant NKT cells...
  9. ncbi request reprint The cell surface expression of SAP-binding receptor CD229 is regulated via its interaction with clathrin-associated adaptor complex 2 (AP-2)
    Juana M Del Valle
    Department of Cellular Biology and Pathology, University of Barcelona School of Medicine, Institut d Investigacions Biomediques August Pi i Sunyer, Barcelona E 08036, Spain
    J Biol Chem 278:17430-7. 2003
    ..These data suggest that CD229 cell surface expression on lymphocytes surface is strongly and differentially regulated within the CD150 family members...
  10. doi request reprint Expression of SLAM (CD150) cell-surface receptors on human B-cell subsets: from pro-B to plasma cells
    Jose de Salort
    Immunology Unit, Department of Cell Biology, Immunology and Neurosciences, Medical School, University of Barcelona, Institut d Investigacions Biomediques August Pi i Sunyer IDIBAPS, C Casanova 143, Barcelona, Spain
    Immunol Lett 134:129-36. 2011
    ..Such heterogeneous expression patterns suggest that SLAM molecules play an essential and non-redundant role in the control of humoral immune responses...
  11. doi request reprint Differential expression of CD150 (SLAM) family receptors by human hematopoietic stem and progenitor cells
    Jordi Sintes
    Department of Cellular Biology and Pathology, Medical School, University of Barcelona, Barcelona, Spain
    Exp Hematol 36:1199-204. 2008
    ..The goal of the present study is to analyze the expression patterns of the CD150 receptors CD48, CD84, CD150 (SLAM), CD229 (Ly9), and CD244 (2B4) on the different sources of human hematopoietic stem and progenitor cells...
  12. pmc Identification and functional characterization of the hepatic stellate cell CD38 cell surface molecule
    Sandra March
    Immunology Unit, Department of Cellular Biology and Pathology, Medical School, University of Barcelona, Barcelona, Spain
    Am J Pathol 170:176-87. 2007
    ..Collectively, our data suggest that CD38 can act as a regulator of HSC activation and effector functions...
  13. doi request reprint Viral immunomodulatory proteins: usurping host genes as a survival strategy
    Pablo Engel
    Department of Cell Biology, Immunology and Neurosciences, Medical School, University of Barcelona, Barcelona, Spain
    Adv Exp Med Biol 738:256-76. 2012
    ..A systematic study of these genes, in addition to unraveling specific virus-host interactions, may supply valuable tools to dissect the molecular basis of immune responses...
  14. doi request reprint Human cytomegalovirus UL7, a homologue of the SLAM-family receptor CD229, impairs cytokine production
    Pablo Engel
    Department of Cell Biology, Immunology, and Neurosciences, Medical School, University of Barcelona, Barcelona, Spain
    Immunol Cell Biol 89:753-66. 2011
    ..These results enhance our understanding of those HCMV-encoded molecules involved in sustaining the balance between HCMV and the host immune system...
  15. ncbi request reprint Identification and characterization of a novel spliced variant that encodes human soluble tumor necrosis factor receptor 2
    Begoña Laínez
    Immunology Unit, Department of Cellular Biology and Pathology, Medical School, University of Barcelona, Institut d Investigacions Biomediques August Pi i Sunyer, 08036 Barcelona, Spain
    Int Immunol 16:169-77. 2004
    ..Our data show that sTNFR2 generated by alternative splicing can be found in sera of healthy individuals, at increased levels in patients with sepsis and at high concentrations in rheumatoid arthritis patients...
  16. doi request reprint New B-cell CD molecules
    Jessica Matesanz-Isabel
    Immunology Unit, Department of Cell Biology, Immunology and Neurosciences, Medical School, University of Barcelona, C Casanova 143, Institut d Investigacions Biomediques August Pi i Sunyer, Barcelona, Spain
    Immunol Lett 134:104-12. 2011
    ..The availability of monoclonal antibodies directed against novel B cell-surface molecules will have broad implications not only for B-cell biology, but also for the development of new diagnostic and therapeutic tools...
  17. doi request reprint Towards a comprehensive human cell-surface immunome database
    M Carmen Díaz-Ramos
    Institut d investigacions Biomèdiques Agust Pi i Sunyer IDIBAPS, Dept of Cell Biology, Immunology and Neurosciences, University of Barcelona, Spain
    Immunol Lett 134:183-7. 2011
    ....
  18. doi request reprint Therapeutic targeting of B cells for rheumatic autoimmune diseases
    Pablo Engel
    Immunology Unit, Department of Cell Biology, Immunology and Neuroscience, Faculty of Medicine, University of Barcelona, Barcelona, Spain
    Pharmacol Rev 63:127-56. 2011
    ....
  19. ncbi request reprint Characterization of platelet and soluble-porcine P-selectin (CD62P)
    Anna Massaguer
    Department of Cellular Biology and Pathology, Immunology Unit, Medical School, University of Barcelona, Barcelona, Spain
    Vet Immunol Immunopathol 96:169-81. 2003
    ..These data suggest that porcine P-selectin is a suitable marker for inflammation and that the mechanism involved in the generation of circulating P-selectin is not proteolytic release...
  20. ncbi request reprint Mouse novel Ly9: a new member of the expanding CD150 (SLAM) family of leukocyte cell-surface receptors
    Victoria Tovar
    Institut d Investigacions Biomediques August Pi i Sunyer, Barcelona, Spain
    Immunogenetics 54:394-402. 2002
    ..Taken together, these data indicate that mouse novel Ly9 is a new member of the expanding CD150 family of cell surface receptors...
  21. ncbi request reprint Identification of Grb2 as a novel binding partner of the signaling lymphocytic activation molecule-associated protein binding receptor CD229
    Margarita Martin
    Unitat d Immunologia, Institut d Investigacions Biomediques August Pi i Sunyer, Departament de Biologia Cellular i Anatomia Patologica, Facultat de Medicina, Universitat de Barcelona, Barcelona, Spain
    J Immunol 174:5977-86. 2005
    ..Altogether, the data suggest a model whereby CD229 ligation attenuates TCR signaling and Grb2 recruitment to CD229 controls its rate of internalization...
  22. doi request reprint The SLAM and SAP gene families control innate and adaptive immune responses
    Silvia Calpe
    Division of Immunology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA
    Adv Immunol 97:177-250. 2008
    ..Here we discuss the current understanding of the structure and function of these recently discovered receptors and adapter molecules in the regulation of adaptive and innate immune responses...
  23. doi request reprint The leukocyte receptor CD84 inhibits Fc epsilon RI-mediated signaling through homophilic interaction in transfected RBL-2H3 cells
    Irene Oliver-Vila
    Grup Immunoreceptors, Institut d Investigació August Pi i Sunyer, Department de Biologia Cellular i Anatomia Patologica, Facultat Medicina, Universitat de Barcelona, Barcelona, Spain
    Mol Immunol 45:2138-49. 2008
    ..These data suggest that CD84 may play a role in modulating Fc epsilon RI-mediated signaling in mast cells. Thus, CD84 could play a protective role against undesired allergic and inflammatory responses...
  24. ncbi request reprint CD molecules 2006--human cell differentiation molecules
    Heddy Zola
    Child Health Research Institute and Adelaide University Discipline of Paediatrics, 72 King William Road, North Adelaide, South Australia 5006, Australia
    J Immunol Methods 319:1-5. 2007
    ..At that meeting the Council, acting as Nomenclature Committee, approved a number of new CD designations and changes to some pre-existing CD designations, which are summarized in this report...
  25. ncbi request reprint The adaptor protein 3BP2 binds human CD244 and links this receptor to Vav signaling, ERK activation, and NK cell killing
    Ifigenia Saborit-Villarroya
    Unitat d Immunologia, Departament de Biologia Cellular i Anatomia Patologica, Facultat de Medicina, Universitat de Barcelona, Spain
    J Immunol 175:4226-35. 2005
    ..These results indicate that CD244-3BP2 association regulates cytolytic function but not IFN-gamma release, reinforcing the hypothesis that, in humans, CD244-mediated cytotoxicity and IFN-gamma release involve distinct NK pathways...
  26. ncbi request reprint CD molecules 2005: human cell differentiation molecules
    Heddy Zola
    Child Health Research Institute, 72 King William Rd, North Adelaide 5006, South Australia, Australia
    Blood 106:3123-6. 2005
    ....
  27. ncbi request reprint Induction of tumor NK-cell immunity by anti-CD69 antibody therapy
    Enric Esplugues
    Departamento de Fisiologia, Universidad de Barcelona, Av Diagonal, 645 Barcelona 08028, Spain
    Blood 105:4399-406. 2005
    ..Modulation of the innate immune system with monoclonal antibodies to host CD69 thus provides a novel means to antagonize tumor growth and metastasis...
  28. pmc Enhanced antitumor immunity in mice deficient in CD69
    Enric Esplugues
    Departmento de Fisiologia, Universidad de Barcelona, Barcelona 08080 Spain
    J Exp Med 197:1093-106. 2003
    ..These data unmask a novel role for CD69 as a negative regulator of anti-tumor responses and show the possibility of a novel approach for the therapy of tumors...
  29. ncbi request reprint Shedding of TNF-alpha receptors, blood pressure, and insulin sensitivity in type 2 diabetes mellitus
    Jose Manuel Fernandez-Real
    Unitat de Diabetologia, Endocrinologia i Nutricio, University Hospital of Girona, 17001 Girona, Spain
    Am J Physiol Endocrinol Metab 282:E952-9. 2002
    ..Our findings suggest that insulin resistance and blood pressure are linked to altered shedding of TNF-alpha receptors in DM-2. The latter seems reversible and is not genetically determined...