Juan Duarte


Affiliation: University of Granada
Country: Spain


  1. Romero M, Toral M, Gómez Guzmán M, Jiménez R, Galindo P, Sánchez M, et al. Antihypertensive effects of oleuropein-enriched olive leaf extract in spontaneously hypertensive rats. Food Funct. 2016;7:584-93 pubmed publisher
    ..In conclusion, OLE exerts antihypertensive effects on genetic hypertension related to the improvement of vascular function as a result of reduced pro-oxidative and pro-inflammatory status. ..
  2. Toral M, Jimenez R, Montoro Molina S, Romero M, Wangensteen R, Duarte J, et al. Thyroid hormones stimulate L-arginine transport in human endothelial cells. J Endocrinol. 2018;: pubmed publisher
    ..This effect seems to be mediated by activation of ?v?3 integrin receptor and subsequent PI3K, MAPK and intracellular Ca2+ signaling pathways. ..
  3. Jimenez R, Lopez Sepulveda R, Romero M, Toral M, Cogolludo A, Perez Vizcaino F, et al. Quercetin and its metabolites inhibit the membrane NADPH oxidase activity in vascular smooth muscle cells from normotensive and spontaneously hypertensive rats. Food Funct. 2015;6:409-14 pubmed publisher
    ..The effect of quercetin-3-glucuronide was due to deconjugation and release of free quercetin. The effect is similar in VSMCs from normotensive and hypertensive animals. ..
  4. Gómez Guzmán M, Jimenez R, Romero M, Sanchez M, Zarzuelo M, Gómez Morales M, et al. Chronic hydroxychloroquine improves endothelial dysfunction and protects kidney in a mouse model of systemic lupus erythematosus. Hypertension. 2014;64:330-7 pubmed publisher
  5. Toral M, Romero M, Jimenez R, Robles Vera I, Tamargo J, Martinez M, et al. Role of UCP2 in the protective effects of PPAR?/? activation on lipopolysaccharide-induced endothelial dysfunction. Biochem Pharmacol. 2016;110-111:25-36 pubmed publisher
  6. Chamorro V, Pandolfi R, Moreno L, Barreira B, Martínez Ramas A, Morales Cano D, et al. Effects of Quercetin in a Rat Model of Hemorrhagic Traumatic Shock and Reperfusion. Molecules. 2016;21: pubmed publisher
    ..We found no bacterial DNA in plasma in these animals. Quercetin partially prevented the changes in blood pressure and lung injury in shock associated to hemorrhage and reperfusion. ..
  7. Romero M, Toral M, Robles Vera I, Sanchez M, Jimenez R, O Valle F, et al. Activation of Peroxisome Proliferator Activator Receptor ?/? Improves Endothelial Dysfunction and Protects Kidney in Murine Lupus. Hypertension. 2017;69:641-650 pubmed publisher
    ..Our findings identify PPAR?/? as a promising target for an alternative approach in the treatment of systemic lupus erythematosus and its associated vascular damage. ..
  8. Robles Vera I, Toral M, Romero M, Jiménez R, Sánchez M, Pérez Vizcaíno F, et al. Antihypertensive Effects of Probiotics. Curr Hypertens Rep. 2017;19:26 pubmed publisher
  9. Toral M, Romero M, Jiménez R, Mahmoud A, Barroso E, Gómez Guzmán M, et al. Carnitine palmitoyltransferase-1 up-regulation by PPAR-β/δ prevents lipid-induced endothelial dysfunction. Clin Sci (Lond). 2015;129:823-37 pubmed publisher
    ..In conclusion, PPARβ/δ activation restored the lipid-induced endothelial dysfunction by up-regulation of CPT-1, thus reducing DAG accumulation and the subsequent PKC-mediated ROS production and eNOS inhibition. ..

More Information


  1. Romero M, Jimenez R, Toral M, León Gómez E, Gómez Guzmán M, Sanchez M, et al. Vascular and Central Activation of Peroxisome Proliferator-Activated Receptor-? Attenuates Angiotensin II-Induced Hypertension: Role of RGS-5. J Pharmacol Exp Ther. 2016;358:151-63 pubmed publisher
  2. Toral M, Jimenez R, Romero M, Robles Vera I, Sanchez M, Salaices M, et al. Role of endoplasmic reticulum stress in the protective effects of PPAR?/? activation on endothelial dysfunction induced by plasma from patients with lupus. Arthritis Res Ther. 2017;19:268 pubmed publisher
    ..These protective effects were abolished by the PPAR?/? antagonist GSK0660 and by silencing PPAR?/?. PPAR?/? activation may be an important target to control endothelial dysfunction in patients with SLE. ..