Dolores Corella


Affiliation: University of Valencia
Country: Spain


  1. Papandreou C, Babio N, Díaz López A, Martinez Gonzalez M, Becerra Tomás N, Corella D, et al. Sleep Duration is Inversely Associated with Serum Uric Acid Concentrations and Uric Acid to Creatinine Ratio in an Elderly Mediterranean Population at High Cardiovascular Risk. Nutrients. 2019;11: pubmed publisher
    ..15, p = 0.001). The findings of this study suggest that longer sleep duration is associated with lower SUA concentrations and lower SUA to creatinine ratio. ..
  2. Bibiloni M, Julibert A, Bouzas C, Martinez Gonzalez M, Corella D, Salas Salvado J, et al. Nut Consumptions as a Marker of Higher Diet Quality in a Mediterranean Population at High Cardiovascular Risk. Nutrients. 2019;11: pubmed publisher
    ..nut consumers had better nutrient adequacy, diet quality, and adherence to the MedDiet than those non-nut consumers. ..
  3. Muralidharan J, Papandreou C, Sala Vila A, Rosique Esteban N, Fito M, Estruch R, et al. Fatty Acids Composition of Blood Cell Membranes and Peripheral Inflammation in the PREDIMED Study: A Cross-Sectional Analysis. Nutrients. 2019;11: pubmed publisher
    ..This study adds to the growing body of evidence suggesting potential differences in inflammatory or anti-inflammatory properties of fatty acids in blood cell membranes. ..
  4. Garcia Arellano A, Martinez Gonzalez M, Ramallal R, Salas Salvado J, Hebert J, Corella D, et al. Dietary inflammatory index and all-cause mortality in large cohorts: The SUN and PREDIMED studies. Clin Nutr. 2018;: pubmed publisher
    ..The SUN cohort and PREDIMED trial were registered at as NCT02669602 and at as ISRCTN35739639, respectively. ..
  5. Coltell O, Asensio E, Sorli J, Barragán R, Fernández Carrión R, Portoles O, et al. Genome-Wide Association Study (GWAS) on Bilirubin Concentrations in Subjects with Metabolic Syndrome: Sex-Specific GWAS Analysis and Gene-Diet Interactions in a Mediterranean Population. Nutrients. 2019;11: pubmed publisher
    ..In conclusion, our study provides new data, with a gender perspective, on genes associated with total serum bilirubin concentrations in men and women, and suggests possible additional modulations by adherence to MedDiet. ..
  6. Sanchez Villegas A, Álvarez Pérez J, Toledo E, Salas Salvado J, Ortega Azorín C, Zomeño M, et al. Seafood Consumption, Omega-3 Fatty Acids Intake, and Life-Time Prevalence of Depression in the PREDIMED-Plus Trial. Nutrients. 2018;10: pubmed publisher
    ..5⁻1 g/day) was significantly associated with a lower prevalence of depression. In our study, moderate fish and LC ω-3 PUFA intake, but not high intake, was associated with lower odds of depression suggesting a U-shaped relationship. ..
  7. Corella D, Coltell O, Portoles O, Sotos Prieto M, Fernández Carrión R, Ramirez Sabio J, et al. A Guide to Applying the Sex-Gender Perspective to Nutritional Genomics. Nutrients. 2018;11: pubmed publisher
  8. Cano Ibáñez N, Bueno Cavanillas A, Martinez Gonzalez M, Corella D, Salas Salvado J, Zomeño M, et al. Dietary Intake in Population with Metabolic Syndrome: Is the Prevalence of Inadequate Intake Influenced by Geographical Area? Cross-Sectional Analysis from PREDIMED-Plus Study. Nutrients. 2018;10: pubmed publisher
    ..001). Sex (women), non-smoker and physical activity were also associated to adequate nutrient intake. Geographical area influences nutrient intakes. Its effect on dietary quality should be taken into account when planning food policies. ..
  9. Barragán R, Coltell O, Portoles O, Asensio E, Sorli J, Ortega Azorín C, et al. Bitter, Sweet, Salty, Sour and Umami Taste Perception Decreases with Age: Sex-Specific Analysis, Modulation by Genetic Variants and Taste-Preference Associations in 18 to 80 Year-Old Subjects. Nutrients. 2018;10: pubmed publisher

More Information


  1. Corella D, Carrasco P, Sorli J, Coltell O, Ortega Azorín C, Guillen M, et al. Education modulates the association of the FTO rs9939609 polymorphism with body mass index and obesity risk in the Mediterranean population. Nutr Metab Cardiovasc Dis. 2012;22:651-8 pubmed publisher
    ..27-3.26 for AA subjects). The interaction of the FTO with education remained significant even after adjustment for PA. The association of the FTO SNP with greater BMI and obesity risk in the GP was strongly modulated by education. ..
  2. Corella D, Barragán R, Ordovas J, Coltell O. [Nutrigenetics, nutrigenomics and Mediterranean diet: a new vision for gastronomy]. Nutr Hosp. 2018;35:19-27 pubmed publisher
    ..Todo ello, bien integrado, puede contribuir al incremento del disfrute a la vez que se sigue una alimentación saludable. ..
  3. Corella D, Ordovas J. [The role of omics in precision nutrition: strengths and weaknesses]. Nutr Hosp. 2018;35:10-18 pubmed publisher
    ..En este contexto, revisaremos el papel de las ómicas en la nutrición de precisión, así como sus principales fortalezas y debilidades. ..
  4. Garcia Arellano A, Ramallal R, Ruiz Canela M, Salas Salvadó J, Corella D, Shivappa N, et al. Dietary Inflammatory Index and Incidence of Cardiovascular Disease in the PREDIMED Study. Nutrients. 2015;7:4124-38 pubmed publisher
    ..22 (1.06-1.40). Our results provide direct prospective evidence that a pro-inflammatory diet is associated with a higher risk of cardiovascular clinical events. ..
  5. Corella D, Ordovas J. Interactions between dietary n-3 fatty acids and genetic variants and risk of disease. Br J Nutr. 2012;107 Suppl 2:S271-83 pubmed publisher
  6. Sánchez Tainta A, Zazpe I, Bes Rastrollo M, Salas Salvadó J, Bullo M, Sorlí J, et al. Nutritional adequacy according to carbohydrates and fat quality. Eur J Nutr. 2016;55:93-106 pubmed publisher
    ..A multidimensional assessment of CQI can be a useful tool to evaluate the quality of carbohydrates. This score and a 14-item Med-diet score were positively related to overall micronutrient adequacy in elderly participants. ..
  7. Corella D, Ordovás J. Biomarkers: background, classification and guidelines for applications in nutritional epidemiology. Nutr Hosp. 2015;31 Suppl 3:177-88 pubmed publisher
    ..Revisaremos el estado actual de los biomarcadores en epidemiología nutricional así como las tendencias futuras de los nuevos biomarcadores ómicos. ..
  8. Quiles L, Portolés O, Sorlí J, Corella D. [SHORT TERM EFFECTS ON LIPID PROFILE AND GLYCAEMIA OF A LOW-FAT VEGETARIAN DIET]. Nutr Hosp. 2015;32:156-64 pubmed publisher
    ..También produjo un descenso esperable de C-HDL al ser reducida en grasa. ..
  9. Fito M, Melander O, Martinez J, Toledo E, Carpene C, Corella D. Advances in Integrating Traditional and Omic Biomarkers When Analyzing the Effects of the Mediterranean Diet Intervention in Cardiovascular Prevention. Int J Mol Sci. 2016;17: pubmed publisher
    ..Nevertheless, these preliminary results can help to better understand the inter-individual differences in cardiovascular risk and dietary response for further applications in personalized nutrition. ..
  10. Arpón A, Milagro F, Razquin C, Corella D, Estruch R, Fito M, et al. Impact of Consuming Extra-Virgin Olive Oil or Nuts within a Mediterranean Diet on DNA Methylation in Peripheral White Blood Cells within the PREDIMED-Navarra Randomized Controlled Trial: A Role for Dietary Lipids. Nutrients. 2017;10: pubmed publisher
  11. Guo X, Tresserra Rimbau A, Estruch R, Martínez González M, Medina Remón A, Fitó M, et al. Polyphenol Levels Are Inversely Correlated with Body Weight and Obesity in an Elderly Population after 5 Years of Follow Up (The Randomised PREDIMED Study). Nutrients. 2017;9: pubmed publisher
    ..408; 95% CI: -0.788 to -0.028, p = 0.036) after adjustments for potential confounders. To conclude, a greater polyphenol intake may thus contribute to reducing body weight in elderly people at high cardiovascular risk. ..
  12. Corella D, Arnett D, Tucker K, Kabagambe E, Tsai M, Parnell L, et al. A high intake of saturated fatty acids strengthens the association between the fat mass and obesity-associated gene and BMI. J Nutr. 2011;141:2219-25 pubmed publisher
    ..006 in BPRHS). No associations with BMI were found at lower SFA intakes. We found no significant interactions with carbohydrate intake. In conclusion, SFA intake modulates the association between FTO and BMI in American populations. ..
  13. Valderas Martínez P, Chiva Blanch G, Casas R, Arranz S, Martínez Huelamo M, Urpi Sarda M, et al. Tomato Sauce Enriched with Olive Oil Exerts Greater Effects on Cardiovascular Disease Risk Factors than Raw Tomato and Tomato Sauce: A Randomized Trial. Nutrients. 2016;8:170 pubmed publisher
    ..We concluded that tomato intake has beneficial effects on cardiovascular risk factors, especially cooked and enriched with oil. ..
  14. García Layana A, Ciufo G, Toledo E, Martínez González M, Corella D, Fitó M, et al. The Effect of a Mediterranean Diet on the Incidence of Cataract Surgery. Nutrients. 2017;9: pubmed publisher
    ..Further studies are necessary to investigate whether a MedDiet could have a preventive role in cataract surgery. ..
  15. Corella D, Asensio E, Coltell O, Sorlí J, Estruch R, Martínez González M, et al. CLOCK gene variation is associated with incidence of type-2 diabetes and cardiovascular diseases in type-2 diabetic subjects: dietary modulation in the PREDIMED randomized trial. Cardiovasc Diabetol. 2016;15:4 pubmed publisher
    ..Moreover, we report for the first time an association between a CLOCK polymorphism and stroke in T2D subjects, suggesting that core clock genes may significantly contribute to increased CVD risk in T2D. ..
  16. Corella D, Coltell O, Macian F, Ordovás J. Advances in Understanding the Molecular Basis of the Mediterranean Diet Effect. Annu Rev Food Sci Technol. 2018;9:227-249 pubmed publisher
  17. Barragán R, Coltell O, Asensio E, Frances F, Sorli J, Estruch R, et al. MicroRNAs and Drinking: Association between the Pre-miR-27a rs895819 Polymorphism and Alcohol Consumption in a Mediterranean Population. Int J Mol Sci. 2016;17: pubmed publisher
    ..In conclusion, we report for the first time a significant association between a miRNA polymorphism (rs895819) and daily alcohol consumption. ..
  18. Corella D, Coltell O, Sorli J, Estruch R, Quiles L, Martinez Gonzalez M, et al. Polymorphism of the Transcription Factor 7-Like 2 Gene (TCF7L2) Interacts with Obesity on Type-2 Diabetes in the PREDIMED Study Emphasizing the Heterogeneity of Genetic Variants in Type-2 Diabetes Risk Prediction: Time for Obesity-Specific Genetic Ri. Nutrients. 2016;8: pubmed
    ..In conclusion, we provide strong evidence supporting the need for considering obesity when analyzing the TCF7L2 effects and propose the use of obesity-specific GRS for T2D. ..
  19. Zanon Moreno V, Ortega Azorín C, Asensio Marquez E, Garcia Medina J, Pinazo Duran M, Coltell O, et al. A Multi-Locus Genetic Risk Score for Primary Open-Angle Glaucoma (POAG) Variants Is Associated with POAG Risk in a Mediterranean Population: Inverse Correlations with Plasma Vitamin C and E Concentrations. Int J Mol Sci. 2017;18: pubmed publisher
  20. Bargallo N, Gilabert R, Romero Mamani E, Cofan M, Calder P, Fito M, et al. Red Blood Cell Eicosapentaenoic Acid Inversely Relates to MRI-Assessed Carotid Plaque Lipid Core Burden in Elders at High Cardiovascular Risk. Nutrients. 2017;9: pubmed publisher
    ..The inverse association between EPA and plaque lipid content in patients with advanced atherosclerosis supports the notion that this fatty acid might improve cardiovascular health through stabilization of advanced atheroma plaques. ..
  21. Corella D, Ordovas J. Basic Concepts in Molecular Biology Related to Genetics and Epigenetics. Rev Esp Cardiol (Engl Ed). 2017;70:744-753 pubmed publisher
    ..could alter the epigenome, resulting in healthy or unhealthy cardiovascular phenotypes. We discuss some gene-environment interactions and provide a methodological overview. ..
  22. Corella D, Carrasco P, Sorli J, Estruch R, Rico Sanz J, Martinez Gonzalez M, et al. Mediterranean diet reduces the adverse effect of the TCF7L2-rs7903146 polymorphism on cardiovascular risk factors and stroke incidence: a randomized controlled trial in a high-cardiovascular-risk population. Diabetes Care. 2013;36:3803-11 pubmed publisher
    ..96 [95% CI 0.49-1.87]; P = 0.892 for TT compared with CC). Our novel results suggest that MedDiet may not only reduce increased fasting glucose and lipids in TT individuals, but also stroke incidence. ..
  23. Corella D, Ortega Azorín C, Sorli J, Covas M, Carrasco P, Salas Salvado J, et al. Statistical and biological gene-lifestyle interactions of MC4R and FTO with diet and physical activity on obesity: new effects on alcohol consumption. PLoS ONE. 2012;7:e52344 pubmed publisher
    ..001). Statistical and biological interactions with PA and diet modulate the effects of FTO and MC4R polymorphisms on obesity. The novel association with alcohol consumption seems independent of their effects on BMI. ..
  24. Corella D, Arregui M, Coltell O, Portoles O, Guillem Sáiz P, Carrasco P, et al. Association of the LCT-13910C>T polymorphism with obesity and its modulation by dairy products in a Mediterranean population. Obesity (Silver Spring). 2011;19:1707-14 pubmed publisher
    ..In conclusion, despite not finding marked differences in dairy product consumption, this polymorphism was strongly associated with BMI and obesity and modulated by lactose intake in this Mediterranean population. ..
  25. Corella D, Carrasco P, Amiano P, Arriola L, Chirlaque M, Huerta J, et al. Common cholesteryl ester transfer protein gene variation related to high-density lipoprotein cholesterol is not associated with decreased coronary heart disease risk after a 10-year follow-up in a Mediterranean cohort: Modulation by alcohol consumpti. Atherosclerosis. 2010;211:531-8 pubmed publisher
    ..In this Mediterranean population, the CETP-TaqIB polymorphism was not associated with a lower CHD incidence, and its effect was modulated by alcohol and possibly by diabetes. ..
  26. Corella D, González J, Bullo M, Carrasco P, Portoles O, Diez Espino J, et al. Polymorphisms cyclooxygenase-2 -765G>C and interleukin-6 -174G>C are associated with serum inflammation markers in a high cardiovascular risk population and do not modify the response to a Mediterranean diet supplemented with virgin olive oil o. J Nutr. 2009;139:128-34 pubmed publisher
  27. request reprint
    Corella D, Ordovas J. SINGLE NUCLEOTIDE POLYMORPHISMS THAT INFLUENCE LIPID METABOLISM: Interaction with Dietary Factors. Annu Rev Nutr. 2005;25:341-90 pubmed
    ..In summary, there is need for both large population studies and well-standardized intervention studies. ..
  28. request reprint
    Corella D, Guillen M, Portoles O, Sorli J, Alonso V, Folch J, et al. Gender specific associations of the Trp64Arg mutation in the beta3-adrenergic receptor gene with obesity-related phenotypes in a Mediterranean population: interaction with a common lipoprotein lipase gene variation. J Intern Med. 2001;250:348-60 pubmed
    ..The Trp64Arg mutation was associated with BMI and lipids in men. In women, an additional gene-gene interaction with the LPL-HindIII polymorphism may explain the results. ..
  29. Corella D, Sorli J, Gonzalez J, Ortega C, Fito M, Bullo M, et al. Novel association of the obesity risk-allele near Fas Apoptotic Inhibitory Molecule 2 (FAIM2) gene with heart rate and study of its effects on myocardial infarction in diabetic participants of the PREDIMED trial. Cardiovasc Diabetol. 2014;13:5 pubmed publisher
    ..Furthermore, our results suggest a possible association of this polymorphism with higher myocardial infarction risk in type-2 diabetic subjects, although this result needs to be replicated as it could represent a false positive. ..
  30. Corella D, Carrasco P, Fito M, Martinez Gonzalez M, Salas Salvado J, Aros F, et al. Gene-environment interactions of CETP gene variation in a high cardiovascular risk Mediterranean population. J Lipid Res. 2010;51:2798-807 pubmed publisher
    ..In conclusion, the strong association of the CETP SNPs and HDL-C was not statistically modified by diet or by the other environmental factors. ..