Research Topics
Genomes and Genes | Fernando CiveiraSummaryAffiliation: University of Zaragoza Country: Spain Publications
| Collaborators
|
Detail Information
Publications
Ezetimibe/simvastatin 10/40 mg versus atorvastatin 40 mg in high cardiovascular risk patients with primary hypercholesterolemia: a randomized, double-blind, active-controlled, multicenter studyPaul Kah Hing Ling
School of Medicine and Health Sciences, Monash University, 80100 Johor Bahru, Malaysia
Lipids Health Dis 11:18. 2012..Percentage of subjects achieving LDL-C < 1.81 mmol/L, < 2.00 mmol/L, or < 2.59 mmol/L was assessed using a logistic regression model with terms for treatment and stratum. Tolerability was assessed...
Omega-3 fatty acids and HDL. How do they work in the prevention of cardiovascular disease?Elena Burillo
Laboratorio de Investigacion Molecular, University Hospital Miguel Servet, Instituto de Investigación Sanitaria de Aragón, Zaragoza, Spain
Curr Vasc Pharmacol 10:432-41. 2012..In this review, we summarize the main effects of ω-3 PUFAs on HDL-cholesterol, HDL subfractions, and its main proteins, apolipoproteins (apo) AI and AII. The shared cardioprotective actions of ω-3 PUFAs and HDL are reviewed as well...
Comparison of genetic versus clinical diagnosis in familial hypercholesterolemiaFernando Civeira
Hospital Universitario Miguel Servet, Instituto Aragones de Ciencias de la Salud, Zaragoza, Spain
Am J Cardiol 102:1187-93, 1193.e1. 2008..In conclusion, TX and age-adjusted LDL cholesterol cut-off values have the highest value for clinical diagnosis and indication of genetic testing in FH...- Frequency of low-density lipoprotein receptor gene mutations in patients with a clinical diagnosis of familial combined hyperlipidemia in a clinical settingFernando Civeira
Unidad de Lípidos and Laboratorio de Investigación Molecular, Hospital Universitario Miguel Servet, Instituto Aragones de Ciencias de la Salud, Zaragoza, Spain
J Am Coll Cardiol 52:1546-53. 2008.... - Tendon xanthomas in familial hypercholesterolemia are associated with cardiovascular risk independently of the low-density lipoprotein receptor gene mutationFernando Civeira
Laboratorio de Investigacion Molecular, Hospital Universitario Miguel Servet, Instituto Aragones de Ciencias de la Salud, Zaragoza, Spain
Arterioscler Thromb Vasc Biol 25:1960-5. 2005..To investigate the significance of tendon xanthomas (TX) in heterozygous subjects with familial hypercholesterolemia (hFH)... - Guidelines for the diagnosis and management of heterozygous familial hypercholesterolemiaFernando Civeira
Lipid Unit, Hospital Universitario Miguel Servet, Avda Isabel La Catolica 1 3, 50009 Zaragoza, Spain
Atherosclerosis 173:55-68. 2004.... - Apolipoprotein E gene mutations in subjects with mixed hyperlipidemia and a clinical diagnosis of familial combined hyperlipidemiaMaria Solanas-Barca
Hospital Universitario Miguel Servet, Instituto Aragones de Ciencias de la Salud I CS, Zaragoza, Spain
Atherosclerosis 222:449-55. 2012..We aimed to identify APOE mutations associated with dominant combined hyperlipoproteinemia and to establish their frequency in subjects with a clinical diagnosis of FCHL... - The apolipoprotein B R3500Q gene mutation in Spanish subjects with a clinical diagnosis of familial hypercholesterolemiaSergio Castillo
Departamento de Bioqui mica y Biologi a Molecular y Celular, Facultad de Ciencias, Universidad de Zaragoza, Plaza San Francisco s n, 51008, Zaragoza, Spain
Atherosclerosis 165:127-35. 2002..In conclusion, the R3500Q mutation of the apolipoprotein B gene, a common cause of FH in central Europe, is infrequent in the general Spanish population, but it is common in Galicia... - Mutations in HFE causing hemochromatosis are associated with primary hypertriglyceridemiaMaria Solanas-Barca
Unidad de Lípidos and Laboratorio de Investigación Molecular, Hospital Universitario Miguel Servet, Instituto Aragones de Ciencias de la Salud I CS, 50009 Zaragoza, Spain
J Clin Endocrinol Metab 94:4391-7. 2009..Elevated iron storage is associated with metabolic syndrome, diabetes, and obesity, and all of them are associated with HTG... - Proteomic study of macrophages exposed to oxLDL identifies a CAPG polymorphism associated with carotid atherosclerosisElena Burillo
Unidad de Lipidos, Laboratorio de Investigacion Molecular, Hospital Universitario Miguel Servet, Instituto Aragones de Ciencias de la Salud, Paseo Isabel la católica, 1 3, 50009 Zaragoza, Spain
Atherosclerosis 207:32-7. 2009..Macrophages play a key role in the development of atherosclerosis. The objective of this observational study was to characterize the proteome of macrophages to identify proteins implicated in atherosclerosis... - Screening of APOB gene mutations in subjects with clinical diagnosis of familial hypercholesterolemiaErardo Meriño-Ibarra
Departamento de Bioquimica y Biologia Molecular y Celular, Facultad de Ciencias, Universidad de Zaragoza, Plaza San Francisco s n, 50009 Zaragoza, Spain
Hum Biol 77:663-73. 2005..We conclude that FDB is not a common cause of ADMH in Spain; the R3500Q mutation is the only mutation in APOB causing FDB, and the LDL receptor binding domain of APOB is highly conserved in the studied sample... - Effect of lean red meat from lamb v. lean white meat from chicken on the serum lipid profile: a randomised, cross-over study in womenRocio Mateo-Gallego
Lipid Unit, Hospital Universitario Miguel Servet, Instituto Aragonés de Ciencias de Salud I CS, Avenida Isabel La Católica 1 3, 50009 Zaragoza, Spain
Br J Nutr 107:1403-7. 2012..In conclusion, consumption of lean red meat (lamb) or lean white meat (chicken) as part of the usual diet is associated with a similar lipid response. These two foods can be exchanged in a healthy diet to increase palatability... - Genetic variation in the hepatic lipase gene is associated with combined hyperlipidemia, plasma lipid concentrations, and lipid-lowering drug responseAna Cenarro
Laboratorio de Investigacion Molecular, Hospital Universitario Miguel Servet, Zaragoza, Spain
Am Heart J 150:1154-62. 2005..We have investigated whether common polymorphisms in the hepatic lipase gene (LIPC) influence the baseline lipid concentration and the response to atorvastatin or bezafibrate in patients with CHL... - Atorvastatin decreases stearoyl-CoA desaturase gene expression in THP-1 macrophages incubated with oxidized LDLPaula Martín-Fuentes
Laboratorio de Investigacion Molecular, Instituto Aragones de Ciencias de la Salud I CS, Hospital Universitario Miguel Servet, Edificio de Consultas Externas, planta 4 feminine, c Cardenal Gomá, S N, 50009 Zaragoza, Spain
Lipids 44:115-23. 2009..This would suggest that inhibition of SCD in THP-1 macrophages incubated with oxLDL and the change in fatty acid composition is an important effect of atorvastatin... - Serum chitotriosidase activity, a marker of activated macrophages, predicts new cardiovascular events independently of C-reactive proteinMarta Artieda
Laboratorio de Investigacion Molecular, Hospital Universitario Miguel Servet, Zaragoza, Spain
Cardiology 108:297-306. 2007..Therefore, we sought to determine if serum chitotriosidase activity predicts the risk of new coronary events, and to analyze its relationship with CRP... - Individual variation of scavenger receptor expression in human macrophages with oxidized low-density lipoprotein is associated with a differential inflammatory responsePaula Martín-Fuentes
Laboratorio de Investigacion Molecular, Hospital Universitario Miguel Servet, Instituto Aragones de Ciencias de la Salud, Paseo Isabel la Católica 103, 50009 Zaragoza, Spain
J Immunol 179:3242-8. 2007..926, p = 0.024). These data would suggest that the type of SR could determine the macrophage activation: more proinflammatory when associated to CD36 and LOX-1 than when associated with SR-A... - Association and linkage disequilibrium analyses of APOE polymorphisms in atherosclerosisMarta Artieda
Laboratory of Molecular Investigation, University Hospital Miguel Servet, Aragonian Health Sciences Institute, Zaragoza, Spain
Dis Markers 24:65-72. 2008.... - Iron deposits and dietary patterns in familial combined hyperlipidemia and familial hypertriglyceridemiaRocio Mateo-Gallego
Instituto Aragones de Ciencias de la Salud I CS, Unidad de Lípidos and Laboratorio de Investigación Molecular, Hospital Universitario Miguel Servet, Avda Isabel La Católica, Zaragoza, Spain
J Physiol Biochem 66:229-36. 2010..Our results highly support the concept that the genetic mechanisms driven to hypertriglyceridemia also favor iron overload... - New contributions to the study of common double mutants in the human LDL receptor geneM Teresa Tejedor
Departamento de Anatomia, Embriologia y Genetica, Universidad de Zaragoza, C Miguel Servet 177, 50013, Zaragoza, Spain
Naturwissenschaften 98:943-9. 2011..The origin of p.Gln92Glu and c.313 + 1G>C appears to be in Spain whereas p.Asn564His and p.Lys799_Phe801del could have been introduced in Spain by Celtic migrations in the seventh to fifth centuries BC... - Serum ferritin is a major determinant of lipid phenotype in familial combined hyperlipidemia and familial hypertriglyceridemiaRocio Mateo-Gallego
Unidad de Lípidos and Laboratorio de Investigación Molecular, Hospital Universitario Miguel Servet, Instituto Aragones de Ciencias de la Salud, 50009 Zaragoza, Spain
Metabolism 59:154-8. 2010..In summary, serum ferritin is commonly increased in FCH and in FHTG, it is not related with the presence of metabolic syndrome, and it is highly correlated with liver enzymes... - Overexpression of the CXCL3 gene in response to oxidized low-density lipoprotein is associated with the presence of tendon xanthomas in familial hypercholesterolemiaPaula Martín-Fuentes
Laboratorio de Investigacion Molecular, Hospital Universitario Miguel Servet, Instituto Aragones de Ciencias de la Salud I CS, Zaragoza, Spain
Biochem Cell Biol 87:493-8. 2009..We propose that chemokines belonging to the CXC family could play an important role in the etiology of TX, with CXCL3 being a possible biological marker of onset and development of TX... - Effect of phlebotomy on lipid metabolism in subjects with hereditary hemochromatosisPaola Casanova-Esteban
Unidad de Lípidos and Laboratorio de Investigación Molecular, Hospital Universitario Miguel Servet, Instituto Aragones de Ciencias de la Salud I CS, 50009 Zaragoza, Spain
Metabolism 60:830-4. 2011..Our results suggest that therapeutic phlebotomy could be a useful therapeutic approach in patients with HTG and iron overload... - [Sensitivity and specificity of metabolic syndrome criteria for insulin resistance diagnosis in Spanish population]Erardo Meriño Ibarra
Laboratorio de Investigacion Molecular, Hospital Universitario Miguel Servet, Instituto Aragones de Ciencias de la Salud, Universidad de Zaragoza, Zaragoza, Espana
Med Clin (Barc) 128:168-71. 2007..However, the sensitivity of these new criteria has not been established. The aim of the present study was to define the sensitivity and specificity of the different criteria used for the diagnosis of the MS in our population... - Beneficial effects of omega-3 fatty acids in the proteome of high-density lipoprotein proteomeElena Burillo
Laboratorio de Investigación Molecular and Unidad de Lípidos, Hospital Universitario Miguel Servet, Instituto de Investigación Sanitaria IIS, Zaragoza, Spain
Lipids Health Dis 11:116. 2012..The objective of the study was to compare the proteome of HDL before and after ω-3 PUFAs supplemented diet... - High-density lipoprotein cholesterol increase and non-cardiovascular mortality: a meta-analysisElena Burillo
Laboratorio de Investigacion Molecular, Hospital Universitario Miguel Servet, Zaragoza, Spain
Heart 96:1345-51. 2010..However, the potential benefit of the pharmacological increase in HDL cholesterol has not been clearly demonstrated. Moreover, in some interventions an increase in total mortality has been reported... - Serum chitotriosidase activity is increased in subjects with atherosclerosis diseaseMarta Artieda
Laboratorio de Investigacion Molecular, Hospital Universitario Miguel Servet, Isabel la Catolica, 1 3, 50009 Zaragoza, Spain
Arterioscler Thromb Vasc Biol 23:1645-52. 2003.... - Familial hypercholesterolemia in Spain: case-finding program, clinical and genetic aspectsMiguel Pocovi
Departamento de Bioquimica y Biologia Molecular y Celular, Universidad de Zaragoza, Zaragoza, Spain
Semin Vasc Med 4:67-74. 2004..To further facilitate FH case-finding and patient follow-up, we initiated the publication of a set of guidelines for diagnosis and clinical management of FH that can be applied internationally... - Aragon workers' health study--design and cohort descriptionJose A Casasnovas
Cardiovascular Research Unit, Instituto Aragones de Ciencias de la Salud I CS, Zaragoza, Spain
BMC Cardiovasc Disord 12:45. 2012..The objective of this paper is to describe the study design, aims and baseline characteristics of participants in the AWHS... - Ultrasonography for the evaluation of visceral fat and the metabolic syndromeErardo Meriño-Ibarra
Laboratorio de Investigacion Molecular, Servicio de Medicina Interna, Hospital Universitario Miguel Servet, 50009 Zaragoza, Spain
Metabolism 54:1230-5. 2005.... - Age and sex influence the relationship between waist circumference and abdominal fat distribution measured by bioelectrical impedanceRocio Mateo-Gallego
Lipid Unit, Hospital Universitario Miguel Servet, Instituto Aragones de Ciencias de la Salud I CS, Zaragoza, Spain
Nutr Res 32:466-9. 2012..A specific BIA method that measures abdominal composition would be useful in women and in those subjects with normal WC as an indicator of AVF... - Carotid intima-media thickness in subjects with no cardiovascular risk factorsEstibaliz Jarauta
Unidad de Lipidos, Hospital Universitario Miguel Servet, Instituto Aragones de Ciencias de la Salud I CS, Zaragoza, Spain
Rev Esp Cardiol 63:97-102. 2010..81-1.11 mm in men and from 0.66-1.13 mm in women. The main parameters determining the intima-media thickness were age, male sex, systolic blood pressure and low-density lipoprotein cholesterol level... - Tendon xanthomas in familial hypercholesterolemia are associated with a differential inflammatory response of macrophages to oxidized LDLMarta Artieda
Laboratorio de Investigacion Molecular, Hospital Universitario Miguel Servet, Instituto Aragones de Ciencias de la Salud, Isabel la Catolica 1 3, Zaragoza 50009, Spain
FEBS Lett 579:4503-12. 2005..We propose that TX formation are associated with higher intracellular lipid content, and higher inflammatory response of macrophages in response to oxLDL... - Analysis of apolipoprotein A-I, lecithin:cholesterol acyltransferase and glucocerebrosidase genes in hypoalphalipoproteinemiaDelia Recalde
Departamento de Bioquimica y Biologia Molecular y Celular, Facultad de Ciencias, Universidad de Zaragoza, 50009 Zaragoza, Spain
Atherosclerosis 163:49-58. 2002..In conclusion, 12% of HALP subjects were found to carry mutations in apo A-I, LCAT, or GBA genes, which could explain this phenotype. Our results confirm the molecular, genetic and phenotypic heterogeneity of HALP... - Functional analysis of LDLR promoter and 5' UTR mutations in subjects with clinical diagnosis of familial hypercholesterolemiaIsabel De Castro-Orós
Departamento de Bioquimica y Biologia Molecular y Celular, Universidad de Zaragoza, Instituto Aragones de Ciencias de la Salud, Zaragoza, Spain
Hum Mutat 32:868-72. 2011..This data emphasizes the importance of functional analysis of variants in the LDLR promoter to determine their association with the FH phenotype... - Promoter variant -204A > C of the cholesterol 7α-hydroxylase gene: association with response to plant sterols in humans and increased transcriptional activity in transfected HepG2 cellsIsabel De Castro-Orós
Departamento de Bioquimica y Biologia Molecular y Celular, Facultad de Ciencias, Universidad de Zaragoza, C Pedro Cerbuna 12, 50009 Zaragoza, Spain
Clin Nutr 30:239-46. 2011..We hypothesized that this polymorphism would be associated with variability in lipid responses to PS... - Femoral atherosclerosis in heterozygous familial hypercholesterolemia: influence of the genetic defectMireia Junyent
Unitat de Lípids, Servei d Endocrinologia i Nutrició, Institut d Investigacions Biomediques August Pi i Sunyer, Hospital Clinic, Barcelona, Spain
Arterioscler Thromb Vasc Biol 28:580-6. 2008.... - [Prevalence of dyslipidemia in outpatients of the Spanish health service: the HISPALIPID Study]Onofre Vegazo
Departamento Médico, AstraZeneca Farmacéutica Spain
Med Clin (Barc) 127:331-4. 2006..We intended to estimate the prevalence of dyslipidemia among patients attending outpatient clinics of the Spanish health service... - [Heterozygous familial hypercholesterolemia in Spain. Description of 819 non related cases]Rodrigo Alonso
Med Clin (Barc) 118:487-92. 2002..LDL-c levels, age, gender, smoking, hypertension and body mass index are important predictors of cardiovascular disease in these patients... - Effect of atorvastatin and bezafibrate on plasma levels of C-reactive protein in combined (mixed) hyperlipidemiaJuan A Gómez-Gerique
Biochemistry Service, Fundacion Jimenez Diaz, Avda Reyes Catolicos, 2, 28040, Madrid, Spain
Atherosclerosis 162:245-51. 2002..82, P=0.023). These results suggest a potential anti-atherosclerotic additional benefit of atorvastatin in patients at a risk of cardiovascular disease... - Complement regulation in murine and human hypercholesterolemia and role in the control of macrophage and smooth muscle cell proliferationFrancisco Verdeguer
Laboratory of Vascular Biology, Department of Molecular and Cellular Pathology and Therapy, Instituto de Biomedicina de Valencia IBV CSIC, Spanish Council for Scientific Research, 46010 Valencia, Spain
Cardiovasc Res 76:340-50. 2007.... - The gap between dyslipidemia control perceived by physicians and objective control patterns in SpainJose R Banegas
Departamento de Medicina Preventiva y Salud Publica, Facultad de Medicina, Universidad Autonoma de Madrid, Avda Arzobispo Morcillo s n, 28029 Madrid, Spain
Atherosclerosis 188:420-4. 2006..This study examines physicians' subjective perception of dyslipidemia control, and compares it with control determined objectively with published guidelines... - The use of Achilles tendon sonography to distinguish familial hypercholesterolemia from other genetic dyslipidemiasMireia Junyent
, Servei d'Endocrinologia i Nutrici, , , Barcelona, Spain
Arterioscler Thromb Vasc Biol 25:2203-8. 2005..CONCLUSIONS: Sonographic AT characteristics are normal in non-FH dyslipidemias. Identification of suspected FH by ultrasound using sex- and age-specific AT thickness thresholds is recommended... - [Differences in clinical presentation between subjects with a phenotype of familial hypercholesterolemia determined by defects in the LDL-receptor and defects in Apo B-100]Ignacio García-Alvarez
Departamentos de Medicina y Psiquiatría Hospital Universitario Miguel Servet Zaragoza España
Rev Esp Cardiol 56:769-74. 2003..We used data from first degree relatives to compare morbidity and mortality between the two groups...