Fernando Civeira

Summary

Affiliation: University of Zaragoza
Country: Spain

Publications

  1. pmc The genetic basis of familial hypercholesterolemia: inheritance, linkage, and mutations
    Isabel De Castro-Orós
    Lipid Unit and Laboratorio de Investigación Molecular, Hospital Universitario Miguel Servet, Instituto Aragones de Ciencias de la Salud I CS, Zaragoza, Spain
    Appl Clin Genet 3:53-64. 2010
  2. pmc Ezetimibe/simvastatin 10/40 mg versus atorvastatin 40 mg in high cardiovascular risk patients with primary hypercholesterolemia: a randomized, double-blind, active-controlled, multicenter study
    Paul Kah Hing Ling
    School of Medicine and Health Sciences, Monash University, 80100 Johor Bahru, Malaysia
    Lipids Health Dis 11:18. 2012
  3. ncbi request reprint Omega-3 fatty acids and HDL. How do they work in the prevention of cardiovascular disease?
    Elena Burillo
    Laboratorio de Investigacion Molecular, University Hospital Miguel Servet, Instituto de Investigación Sanitaria de Aragón, Zaragoza, Spain
    Curr Vasc Pharmacol 10:432-41. 2012
  4. ncbi request reprint Guidelines for the diagnosis and management of heterozygous familial hypercholesterolemia
    Fernando Civeira
    Lipid Unit, Hospital Universitario Miguel Servet, Avda Isabel La Catolica 1 3, 50009 Zaragoza, Spain
    Atherosclerosis 173:55-68. 2004
  5. ncbi request reprint Comparison of genetic versus clinical diagnosis in familial hypercholesterolemia
    Fernando Civeira
    Hospital Universitario Miguel Servet, Instituto Aragones de Ciencias de la Salud, Zaragoza, Spain
    Am J Cardiol 102:1187-93, 1193.e1. 2008
  6. doi request reprint Frequency of low-density lipoprotein receptor gene mutations in patients with a clinical diagnosis of familial combined hyperlipidemia in a clinical setting
    Fernando Civeira
    Unidad de Lípidos and Laboratorio de Investigación Molecular, Hospital Universitario Miguel Servet, Instituto Aragones de Ciencias de la Salud, Zaragoza, Spain
    J Am Coll Cardiol 52:1546-53. 2008
  7. ncbi request reprint Tendon xanthomas in familial hypercholesterolemia are associated with cardiovascular risk independently of the low-density lipoprotein receptor gene mutation
    Fernando Civeira
    Laboratorio de Investigacion Molecular, Hospital Universitario Miguel Servet, Instituto Aragones de Ciencias de la Salud, Zaragoza, Spain
    Arterioscler Thromb Vasc Biol 25:1960-5. 2005
  8. doi request reprint Apolipoprotein E gene mutations in subjects with mixed hyperlipidemia and a clinical diagnosis of familial combined hyperlipidemia
    Maria Solanas-Barca
    Hospital Universitario Miguel Servet, Instituto Aragones de Ciencias de la Salud I CS, Zaragoza, Spain
    Atherosclerosis 222:449-55. 2012
  9. ncbi request reprint The apolipoprotein B R3500Q gene mutation in Spanish subjects with a clinical diagnosis of familial hypercholesterolemia
    Sergio Castillo
    Departamento de Bioqui mica y Biologi a Molecular y Celular, Facultad de Ciencias, Universidad de Zaragoza, Plaza San Francisco s n, 51008, Zaragoza, Spain
    Atherosclerosis 165:127-35. 2002
  10. ncbi request reprint Screening of APOB gene mutations in subjects with clinical diagnosis of familial hypercholesterolemia
    Erardo Meriño-Ibarra
    Departamento de Bioquimica y Biologia Molecular y Celular, Facultad de Ciencias, Universidad de Zaragoza, Plaza San Francisco s n, 50009 Zaragoza, Spain
    Hum Biol 77:663-73. 2005

Collaborators

Detail Information

Publications50

  1. pmc The genetic basis of familial hypercholesterolemia: inheritance, linkage, and mutations
    Isabel De Castro-Orós
    Lipid Unit and Laboratorio de Investigación Molecular, Hospital Universitario Miguel Servet, Instituto Aragones de Ciencias de la Salud I CS, Zaragoza, Spain
    Appl Clin Genet 3:53-64. 2010
    ..Actually, drug therapy is focused on using statins and combined therapy with ezetimibe and statins. This review highlights the recent progress made in genetics, diagnosis, and treatment for FH...
  2. pmc Ezetimibe/simvastatin 10/40 mg versus atorvastatin 40 mg in high cardiovascular risk patients with primary hypercholesterolemia: a randomized, double-blind, active-controlled, multicenter study
    Paul Kah Hing Ling
    School of Medicine and Health Sciences, Monash University, 80100 Johor Bahru, Malaysia
    Lipids Health Dis 11:18. 2012
    ..Percentage of subjects achieving LDL-C < 1.81 mmol/L, < 2.00 mmol/L, or < 2.59 mmol/L was assessed using a logistic regression model with terms for treatment and stratum. Tolerability was assessed...
  3. ncbi request reprint Omega-3 fatty acids and HDL. How do they work in the prevention of cardiovascular disease?
    Elena Burillo
    Laboratorio de Investigacion Molecular, University Hospital Miguel Servet, Instituto de Investigación Sanitaria de Aragón, Zaragoza, Spain
    Curr Vasc Pharmacol 10:432-41. 2012
    ..In this review, we summarize the main effects of ω-3 PUFAs on HDL-cholesterol, HDL subfractions, and its main proteins, apolipoproteins (apo) AI and AII. The shared cardioprotective actions of ω-3 PUFAs and HDL are reviewed as well...
  4. ncbi request reprint Guidelines for the diagnosis and management of heterozygous familial hypercholesterolemia
    Fernando Civeira
    Lipid Unit, Hospital Universitario Miguel Servet, Avda Isabel La Catolica 1 3, 50009 Zaragoza, Spain
    Atherosclerosis 173:55-68. 2004
    ....
  5. ncbi request reprint Comparison of genetic versus clinical diagnosis in familial hypercholesterolemia
    Fernando Civeira
    Hospital Universitario Miguel Servet, Instituto Aragones de Ciencias de la Salud, Zaragoza, Spain
    Am J Cardiol 102:1187-93, 1193.e1. 2008
    ..In conclusion, TX and age-adjusted LDL cholesterol cut-off values have the highest value for clinical diagnosis and indication of genetic testing in FH...
  6. doi request reprint Frequency of low-density lipoprotein receptor gene mutations in patients with a clinical diagnosis of familial combined hyperlipidemia in a clinical setting
    Fernando Civeira
    Unidad de Lípidos and Laboratorio de Investigación Molecular, Hospital Universitario Miguel Servet, Instituto Aragones de Ciencias de la Salud, Zaragoza, Spain
    J Am Coll Cardiol 52:1546-53. 2008
    ....
  7. ncbi request reprint Tendon xanthomas in familial hypercholesterolemia are associated with cardiovascular risk independently of the low-density lipoprotein receptor gene mutation
    Fernando Civeira
    Laboratorio de Investigacion Molecular, Hospital Universitario Miguel Servet, Instituto Aragones de Ciencias de la Salud, Zaragoza, Spain
    Arterioscler Thromb Vasc Biol 25:1960-5. 2005
    ..To investigate the significance of tendon xanthomas (TX) in heterozygous subjects with familial hypercholesterolemia (hFH)...
  8. doi request reprint Apolipoprotein E gene mutations in subjects with mixed hyperlipidemia and a clinical diagnosis of familial combined hyperlipidemia
    Maria Solanas-Barca
    Hospital Universitario Miguel Servet, Instituto Aragones de Ciencias de la Salud I CS, Zaragoza, Spain
    Atherosclerosis 222:449-55. 2012
    ..We aimed to identify APOE mutations associated with dominant combined hyperlipoproteinemia and to establish their frequency in subjects with a clinical diagnosis of FCHL...
  9. ncbi request reprint The apolipoprotein B R3500Q gene mutation in Spanish subjects with a clinical diagnosis of familial hypercholesterolemia
    Sergio Castillo
    Departamento de Bioqui mica y Biologi a Molecular y Celular, Facultad de Ciencias, Universidad de Zaragoza, Plaza San Francisco s n, 51008, Zaragoza, Spain
    Atherosclerosis 165:127-35. 2002
    ..In conclusion, the R3500Q mutation of the apolipoprotein B gene, a common cause of FH in central Europe, is infrequent in the general Spanish population, but it is common in Galicia...
  10. ncbi request reprint Screening of APOB gene mutations in subjects with clinical diagnosis of familial hypercholesterolemia
    Erardo Meriño-Ibarra
    Departamento de Bioquimica y Biologia Molecular y Celular, Facultad de Ciencias, Universidad de Zaragoza, Plaza San Francisco s n, 50009 Zaragoza, Spain
    Hum Biol 77:663-73. 2005
    ..We conclude that FDB is not a common cause of ADMH in Spain; the R3500Q mutation is the only mutation in APOB causing FDB, and the LDL receptor binding domain of APOB is highly conserved in the studied sample...
  11. ncbi request reprint Mutations in HFE causing hemochromatosis are associated with primary hypertriglyceridemia
    Maria Solanas-Barca
    Unidad de Lípidos and Laboratorio de Investigación Molecular, Hospital Universitario Miguel Servet, Instituto Aragones de Ciencias de la Salud I CS, 50009 Zaragoza, Spain
    J Clin Endocrinol Metab 94:4391-7. 2009
    ..Elevated iron storage is associated with metabolic syndrome, diabetes, and obesity, and all of them are associated with HTG...
  12. doi request reprint Proteomic study of macrophages exposed to oxLDL identifies a CAPG polymorphism associated with carotid atherosclerosis
    Elena Burillo
    Unidad de Lipidos, Laboratorio de Investigacion Molecular, Hospital Universitario Miguel Servet, Instituto Aragones de Ciencias de la Salud, Paseo Isabel la católica, 1 3, 50009 Zaragoza, Spain
    Atherosclerosis 207:32-7. 2009
    ..Macrophages play a key role in the development of atherosclerosis. The objective of this observational study was to characterize the proteome of macrophages to identify proteins implicated in atherosclerosis...
  13. doi request reprint Effect of Nicotinic acid/Laropiprant in the lipoprotein(a) concentration with regard to baseline lipoprotein(a) concentration and LPA genotype
    Ana Cenarro
    Lipid Unit and Laboratorio de Investigación Molecular, Hospital Universitario Miguel Servet, IIS Aragón, Universidad de Zaragoza, Zaragoza, Spain
    Metabolism 63:365-71. 2014
    ..Significant variation in Lp(a) concentration is specific to LPA gene, which codes for apo(a). Nicotinic acid (NA) is used for treatment of dyslipidemias, and the lowering effect of NA on Lp(a) has been previously reported...
  14. doi request reprint Effect of lean red meat from lamb v. lean white meat from chicken on the serum lipid profile: a randomised, cross-over study in women
    Rocio Mateo-Gallego
    Lipid Unit, Hospital Universitario Miguel Servet, Instituto Aragonés de Ciencias de Salud I CS, Avenida Isabel La Católica 1 3, 50009 Zaragoza, Spain
    Br J Nutr 107:1403-7. 2012
    ..In conclusion, consumption of lean red meat (lamb) or lean white meat (chicken) as part of the usual diet is associated with a similar lipid response. These two foods can be exchanged in a healthy diet to increase palatability...
  15. ncbi request reprint Genetic variation in the hepatic lipase gene is associated with combined hyperlipidemia, plasma lipid concentrations, and lipid-lowering drug response
    Ana Cenarro
    Laboratorio de Investigacion Molecular, Hospital Universitario Miguel Servet, Zaragoza, Spain
    Am Heart J 150:1154-62. 2005
    ..We have investigated whether common polymorphisms in the hepatic lipase gene (LIPC) influence the baseline lipid concentration and the response to atorvastatin or bezafibrate in patients with CHL...
  16. doi request reprint Atorvastatin decreases stearoyl-CoA desaturase gene expression in THP-1 macrophages incubated with oxidized LDL
    Paula Martín-Fuentes
    Laboratorio de Investigacion Molecular, Instituto Aragones de Ciencias de la Salud I CS, Hospital Universitario Miguel Servet, Edificio de Consultas Externas, planta 4 feminine, c Cardenal Gomá, S N, 50009 Zaragoza, Spain
    Lipids 44:115-23. 2009
    ..This would suggest that inhibition of SCD in THP-1 macrophages incubated with oxLDL and the change in fatty acid composition is an important effect of atorvastatin...
  17. ncbi request reprint Serum chitotriosidase activity, a marker of activated macrophages, predicts new cardiovascular events independently of C-reactive protein
    Marta Artieda
    Laboratorio de Investigacion Molecular, Hospital Universitario Miguel Servet, Zaragoza, Spain
    Cardiology 108:297-306. 2007
    ..Therefore, we sought to determine if serum chitotriosidase activity predicts the risk of new coronary events, and to analyze its relationship with CRP...
  18. ncbi request reprint [Sensitivity and specificity of metabolic syndrome criteria for insulin resistance diagnosis in Spanish population]
    Erardo Meriño-Ibarra
    Laboratorio de Investigacion Molecular, Hospital Universitario Miguel Servet, Instituto Aragones de Ciencias de la Salud, Universidad de Zaragoza, Zaragoza, Espana
    Med Clin (Barc) 128:168-71. 2007
    ..However, the sensitivity of these new criteria has not been established. The aim of the present study was to define the sensitivity and specificity of the different criteria used for the diagnosis of the MS in our population...
  19. doi request reprint Iron deposits and dietary patterns in familial combined hyperlipidemia and familial hypertriglyceridemia
    Rocio Mateo-Gallego
    Instituto Aragones de Ciencias de la Salud I CS, Unidad de Lípidos and Laboratorio de Investigación Molecular, Hospital Universitario Miguel Servet, Avda Isabel La Católica, Zaragoza, Spain
    J Physiol Biochem 66:229-36. 2010
    ..Our results highly support the concept that the genetic mechanisms driven to hypertriglyceridemia also favor iron overload...
  20. pmc Association and linkage disequilibrium analyses of APOE polymorphisms in atherosclerosis
    Marta Artieda
    Laboratory of Molecular Investigation, University Hospital Miguel Servet, Aragonian Health Sciences Institute, Zaragoza, Spain
    Dis Markers 24:65-72. 2008
    ....
  21. doi request reprint New contributions to the study of common double mutants in the human LDL receptor gene
    M Teresa Tejedor
    Departamento de Anatomia, Embriologia y Genetica, Universidad de Zaragoza, C Miguel Servet 177, 50013, Zaragoza, Spain
    Naturwissenschaften 98:943-9. 2011
    ..The origin of p.Gln92Glu and c.313 + 1G>C appears to be in Spain whereas p.Asn564His and p.Lys799_Phe801del could have been introduced in Spain by Celtic migrations in the seventh to fifth centuries BC...
  22. doi request reprint Serum ferritin is a major determinant of lipid phenotype in familial combined hyperlipidemia and familial hypertriglyceridemia
    Rocio Mateo-Gallego
    Unidad de Lípidos and Laboratorio de Investigación Molecular, Hospital Universitario Miguel Servet, Instituto Aragones de Ciencias de la Salud, 50009 Zaragoza, Spain
    Metabolism 59:154-8. 2010
    ..In summary, serum ferritin is commonly increased in FCH and in FHTG, it is not related with the presence of metabolic syndrome, and it is highly correlated with liver enzymes...
  23. doi request reprint Effect of phlebotomy on lipid metabolism in subjects with hereditary hemochromatosis
    Paola Casanova-Esteban
    Unidad de Lípidos and Laboratorio de Investigación Molecular, Hospital Universitario Miguel Servet, Instituto Aragones de Ciencias de la Salud I CS, 50009 Zaragoza, Spain
    Metabolism 60:830-4. 2011
    ..Our results suggest that therapeutic phlebotomy could be a useful therapeutic approach in patients with HTG and iron overload...
  24. doi request reprint Overexpression of the CXCL3 gene in response to oxidized low-density lipoprotein is associated with the presence of tendon xanthomas in familial hypercholesterolemia
    Paula Martín-Fuentes
    Laboratorio de Investigacion Molecular, Hospital Universitario Miguel Servet, Instituto Aragones de Ciencias de la Salud I CS, Zaragoza, Spain
    Biochem Cell Biol 87:493-8. 2009
    ..We propose that chemokines belonging to the CXC family could play an important role in the etiology of TX, with CXCL3 being a possible biological marker of onset and development of TX...
  25. ncbi request reprint Serum Lipid Responses to Weight Loss Differ between Overweight Adults with Familial Hypercholesterolemia and Those with Familial Combined Hyperlipidemia
    Rocio Mateo-Gallego
    Unidad de Lípidos and Laboratorio de Investigación Molecular, Hospital Universitario Miguel Servet, Instituto Aragones de Ciencias de la Salud, Zaragoza, Spain
    J Nutr 144:1219-26. 2014
    ..This trial was registered at clinicaltrials.gov as NCT01995149. ..
  26. ncbi request reprint Individual variation of scavenger receptor expression in human macrophages with oxidized low-density lipoprotein is associated with a differential inflammatory response
    Paula Martín-Fuentes
    Laboratorio de Investigacion Molecular, Hospital Universitario Miguel Servet, Instituto Aragones de Ciencias de la Salud, Paseo Isabel la Católica 103, 50009 Zaragoza, Spain
    J Immunol 179:3242-8. 2007
    ..926, p = 0.024). These data would suggest that the type of SR could determine the macrophage activation: more proinflammatory when associated to CD36 and LOX-1 than when associated with SR-A...
  27. pmc Beneficial effects of omega-3 fatty acids in the proteome of high-density lipoprotein proteome
    Elena Burillo
    Laboratorio de Investigación Molecular and Unidad de Lípidos, Hospital Universitario Miguel Servet, Instituto de Investigación Sanitaria IIS, Zaragoza, Spain
    Lipids Health Dis 11:116. 2012
    ..The objective of the study was to compare the proteome of HDL before and after ω-3 PUFAs supplemented diet...
  28. doi request reprint High-density lipoprotein cholesterol increase and non-cardiovascular mortality: a meta-analysis
    Elena Burillo
    Laboratorio de Investigacion Molecular, Hospital Universitario Miguel Servet, Zaragoza, Spain
    Heart 96:1345-51. 2010
    ..However, the potential benefit of the pharmacological increase in HDL cholesterol has not been clearly demonstrated. Moreover, in some interventions an increase in total mortality has been reported...
  29. ncbi request reprint Serum chitotriosidase activity is increased in subjects with atherosclerosis disease
    Marta Artieda
    Laboratorio de Investigacion Molecular, Hospital Universitario Miguel Servet, Isabel la Catolica, 1 3, 50009 Zaragoza, Spain
    Arterioscler Thromb Vasc Biol 23:1645-52. 2003
    ....
  30. ncbi request reprint Familial hypercholesterolemia in Spain: case-finding program, clinical and genetic aspects
    Miguel Pocovi
    Departamento de Bioquimica y Biologia Molecular y Celular, Universidad de Zaragoza, Zaragoza, Spain
    Semin Vasc Med 4:67-74. 2004
    ..To further facilitate FH case-finding and patient follow-up, we initiated the publication of a set of guidelines for diagnosis and clinical management of FH that can be applied internationally...
  31. ncbi request reprint Bile acid synthesis precursors in familial combined hyperlipidemia: the oxysterols 24S-hydroxycholesterol and 27-hydroxycholesterol
    Lucia Baila-Rueda
    Unidad de Lípidos and Laboratorio de Investigación Molecular, Hospital Universitario Miguel Servet, Instituto Aragones de Ciencias de la Salud I CS, Zaragoza, Spain Electronic address
    Biochem Biophys Res Commun 446:731-5. 2014
    ..In summary, our data indicate that high oxysterol levels might be good markers of FCHL, unrelated to fat mass, and may exert a protective mechanism for cholesterol accumulation. ..
  32. pmc A genetic variant in the LDLR promoter is responsible for part of the LDL-cholesterol variability in primary hypercholesterolemia
    Isabel De Castro-Orós
    Departamento de Bioquimica y Biologia Molecular y Celular, Universidad de Zaragoza, C, Pedro Cerbuna 12, 50009 Zaragoza, Spain
    BMC Med Genomics 7:17. 2014
    ..We hypothesized that genetic variants in this region are responsible for the LDLR association with LDL-cholesterol found in GWAS...
  33. pmc Aragon workers' health study--design and cohort description
    Jose A Casasnovas
    Cardiovascular Research Unit, Instituto Aragones de Ciencias de la Salud I CS, Zaragoza, Spain
    BMC Cardiovasc Disord 12:45. 2012
    ..The objective of this paper is to describe the study design, aims and baseline characteristics of participants in the AWHS...
  34. ncbi request reprint [Lipoprotein(a) is associated to atherosclerosis in primary hypercholesterolemia]
    Ana M Bea
    Unidad de Lípidos y Laboratorio de Investigación Molecular, Hospital Universitario Miguel Servet, IIS Aragón, Universidad de Zaragoza, Zaragoza, Espana
    Clin Investig Arterioscler 26:176-83. 2014
    ..Several studies have suggested that Lp(a) could be a risk factor mainly in hypercholesterolemic patients...
  35. doi request reprint Carotid intima-media thickness in subjects with no cardiovascular risk factors
    Estibaliz Jarauta
    Unidad de Lipidos, Hospital Universitario Miguel Servet, Instituto Aragones de Ciencias de la Salud I CS, Zaragoza, Spain Laboratorio de Investigación Molecular, Hospital Universitario Miguel Servet, Instituto Aragones de Ciencias de la Salud I CS, Zaragoza, Spain
    Rev Esp Cardiol (Engl Ed) 63:97-102. 2010
    ..81-1.11mm in men and from 0.66-1.13mm in women. The main parameters determining the intima-media thickness were age, male sex, systolic blood pressure and low-density lipoprotein cholesterol level. ..
  36. doi request reprint Promoter variant -204A > C of the cholesterol 7α-hydroxylase gene: association with response to plant sterols in humans and increased transcriptional activity in transfected HepG2 cells
    Isabel De Castro-Orós
    Departamento de Bioquimica y Biologia Molecular y Celular, Facultad de Ciencias, Universidad de Zaragoza, C Pedro Cerbuna 12, 50009 Zaragoza, Spain
    Clin Nutr 30:239-46. 2011
    ..We hypothesized that this polymorphism would be associated with variability in lipid responses to PS...
  37. ncbi request reprint Ultrasonography for the evaluation of visceral fat and the metabolic syndrome
    Erardo Meriño-Ibarra
    Laboratorio de Investigacion Molecular, Servicio de Medicina Interna, Hospital Universitario Miguel Servet, 50009 Zaragoza, Spain
    Metabolism 54:1230-5. 2005
    ....
  38. doi request reprint Age and sex influence the relationship between waist circumference and abdominal fat distribution measured by bioelectrical impedance
    Rocio Mateo-Gallego
    Lipid Unit, Hospital Universitario Miguel Servet, Instituto Aragones de Ciencias de la Salud I CS, Zaragoza, Spain
    Nutr Res 32:466-9. 2012
    ..A specific BIA method that measures abdominal composition would be useful in women and in those subjects with normal WC as an indicator of AVF...
  39. doi request reprint Functional analysis of LDLR promoter and 5' UTR mutations in subjects with clinical diagnosis of familial hypercholesterolemia
    Isabel De Castro-Orós
    Departamento de Bioquimica y Biologia Molecular y Celular, Universidad de Zaragoza, Instituto Aragones de Ciencias de la Salud, Zaragoza, Spain
    Hum Mutat 32:868-72. 2011
    ..This data emphasizes the importance of functional analysis of variants in the LDLR promoter to determine their association with the FH phenotype...
  40. ncbi request reprint Analysis of apolipoprotein A-I, lecithin:cholesterol acyltransferase and glucocerebrosidase genes in hypoalphalipoproteinemia
    Delia Recalde
    Departamento de Bioquimica y Biologia Molecular y Celular, Facultad de Ciencias, Universidad de Zaragoza, 50009 Zaragoza, Spain
    Atherosclerosis 163:49-58. 2002
    ..In conclusion, 12% of HALP subjects were found to carry mutations in apo A-I, LCAT, or GBA genes, which could explain this phenotype. Our results confirm the molecular, genetic and phenotypic heterogeneity of HALP...
  41. ncbi request reprint Tendon xanthomas in familial hypercholesterolemia are associated with a differential inflammatory response of macrophages to oxidized LDL
    Marta Artieda
    Laboratorio de Investigacion Molecular, Hospital Universitario Miguel Servet, Instituto Aragones de Ciencias de la Salud, Isabel la Catolica 1 3, Zaragoza 50009, Spain
    FEBS Lett 579:4503-12. 2005
    ..We propose that TX formation are associated with higher intracellular lipid content, and higher inflammatory response of macrophages in response to oxLDL...
  42. ncbi request reprint Carotid intima-media thickness in subjects with no cardiovascular risk factors
    Estibaliz Jarauta
    Unidad de Lipidos, Hospital Universitario Miguel Servet, Instituto Aragones de Ciencias de la Salud I CS, Zaragoza, Spain
    Rev Esp Cardiol 63:97-102. 2010
    ..81-1.11 mm in men and from 0.66-1.13 mm in women. The main parameters determining the intima-media thickness were age, male sex, systolic blood pressure and low-density lipoprotein cholesterol level...
  43. ncbi request reprint Femoral atherosclerosis in heterozygous familial hypercholesterolemia: influence of the genetic defect
    Mireia Junyent
    Unitat de Lípids, Servei d Endocrinologia i Nutrició, Institut d Investigacions Biomediques August Pi i Sunyer, Hospital Clinic, Barcelona, Spain
    Arterioscler Thromb Vasc Biol 28:580-6. 2008
    ....
  44. ncbi request reprint Complement regulation in murine and human hypercholesterolemia and role in the control of macrophage and smooth muscle cell proliferation
    Francisco Verdeguer
    Laboratory of Vascular Biology, Department of Molecular and Cellular Pathology and Therapy, Instituto de Biomedicina de Valencia IBV CSIC, Spanish Council for Scientific Research, 46010 Valencia, Spain
    Cardiovasc Res 76:340-50. 2007
    ....
  45. ncbi request reprint [Heterozygous familial hypercholesterolemia in Spain. Description of 819 non related cases]
    Rodrigo Alonso
    Unidad de Lípidos Servicio de Medicina Interna Fundación Jiménez Díaz Madrid Spain
    Med Clin (Barc) 118:487-92. 2002
    ..The aim of this study was to analyze the clinical manifestations and the characteristics of cardiovascular disease in the Spanish hFH population...
  46. ncbi request reprint Effect of atorvastatin and bezafibrate on plasma levels of C-reactive protein in combined (mixed) hyperlipidemia
    Juan A Gómez-Gerique
    Biochemistry Service, Fundacion Jimenez Diaz, Avda Reyes Catolicos, 2, 28040, Madrid, Spain
    Atherosclerosis 162:245-51. 2002
    ..82, P=0.023). These results suggest a potential anti-atherosclerotic additional benefit of atorvastatin in patients at a risk of cardiovascular disease...
  47. ncbi request reprint The gap between dyslipidemia control perceived by physicians and objective control patterns in Spain
    Jose R Banegas
    Departamento de Medicina Preventiva y Salud Publica, Facultad de Medicina, Universidad Autonoma de Madrid, Avda Arzobispo Morcillo s n, 28029 Madrid, Spain
    Atherosclerosis 188:420-4. 2006
    ..This study examines physicians' subjective perception of dyslipidemia control, and compares it with control determined objectively with published guidelines...
  48. ncbi request reprint [Prevalence of dyslipidemia in outpatients of the Spanish health service: the HISPALIPID Study]
    Onofre Vegazo
    Departamento Médico, AstraZeneca Farmacéutica Spain
    Med Clin (Barc) 127:331-4. 2006
    ..We intended to estimate the prevalence of dyslipidemia among patients attending outpatient clinics of the Spanish health service...
  49. ncbi request reprint [Differences in clinical presentation between subjects with a phenotype of familial hypercholesterolemia determined by defects in the LDL-receptor and defects in Apo B-100]
    Ignacio García-Alvarez
    Departamentos de Medicina y Psiquiatría Hospital Universitario Miguel Servet Zaragoza España
    Rev Esp Cardiol 56:769-74. 2003
    ..We used data from first degree relatives to compare morbidity and mortality between the two groups...
  50. ncbi request reprint The use of Achilles tendon sonography to distinguish familial hypercholesterolemia from other genetic dyslipidemias
    Mireia Junyent
    Unitat de Lípids, Servei d Endocrinologia i Nutrició, Institut d Investigacions Biomediques August Pi i Sunyer, Hospital Clinic, Barcelona, Spain
    Arterioscler Thromb Vasc Biol 25:2203-8. 2005
    ..Achilles tendon (AT) xanthomas, specific for familial hypercholesterolemia (FH), may be clinically undetectable. We assessed the usefulness of AT sonography in the diagnosis of FH...