Jaume Bosch

Summary

Affiliation: University of Barcelona
Country: Spain

Publications

  1. ncbi request reprint Prevention of variceal rebleeding
    Jaume Bosch
    Hepatic Haemodynamic Laboratory, Liver Unit, Institut de Malalties Digestives, Hospital Clinic, IDIBAPS, University of Barcelona, 08036, Barcelona, Spain
    Lancet 361:952-4. 2003
  2. ncbi request reprint Recombinant factor VIIa for upper gastrointestinal bleeding in patients with cirrhosis: a randomized, double-blind trial
    Jaime Bosch
    Hospital Clinic, Liver Unit, Barcelona, Spain
    Gastroenterology 127:1123-30. 2004
  3. ncbi request reprint Current management of portal hypertension
    Jaime Bosch
    Hepatic Hemodynamic Laboratory, Liver Unit, IMD, Hospital Clinic, IDIBAPS, University of Barcelona, Villarroel 170, 08036, Barcelona, Spain
    J Hepatol 38:S54-68. 2003
  4. ncbi request reprint Is treatment with nadolol effective against the growth of small esophageal varices in patients with cirrhosis?
    Jaime Bosch
    Liver Unit, Hospital Clinic, University of Barcelona, Spain
    Nat Clin Pract Gastroenterol Hepatol 2:18-9. 2005
  5. doi request reprint Terutroban, a TP-receptor antagonist, reduces portal pressure in cirrhotic rats
    Eugenio Rosado
    Hepatic Hemodynamic Laboratory, Liver Unit, IMDiM, Hospital Clinic, Institut d Investigacions Biomèdiques August Pi i Sunyer IDIBAPS and Ciberehd, University of Barcelona, Barcelona, Spain
    Hepatology 58:1424-35. 2013
  6. doi request reprint Interaction between NO and COX pathways modulating hepatic endothelial cells from control and cirrhotic rats
    Eugenio Rosado
    Hepatic Hemodynamic Laboratory, Liver Unit, IMDiM, Hospital Clinic, Institut d Investigacions Biomèdiques August Pi i Sunyer IDIBAPS and Ciberehd, University of Barcelona, Barcelona, Spain
    J Cell Mol Med 16:2461-70. 2012
  7. doi request reprint Hepatic endothelial dysfunction and abnormal angiogenesis: new targets in the treatment of portal hypertension
    Jaume Bosch
    Hepatic Hemodynamic Laboratory, Liver Unit, Hospital Clínic IDIBAPS and Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas, Spain
    J Hepatol 53:558-67. 2010
  8. doi request reprint Resveratrol improves intrahepatic endothelial dysfunction and reduces hepatic fibrosis and portal pressure in cirrhotic rats
    Marco Di Pascoli
    Hepatic Hemodynamic Laboratory, Liver Unit, Hospital Clinic, Institut d Investigacions Biomèdiques August Pi i Sunyer and Ciberehd, University of Barcelona, Spain
    J Hepatol 58:904-10. 2013
  9. doi request reprint Increased oxidative stress in cirrhotic rat livers: A potential mechanism contributing to reduced nitric oxide bioavailability
    Jorge Gracia-Sancho
    Hepatic Hemodynamic Laboratory, Liver Unit, Institut de Malalties Digestives i Metabòliques IMDiM, Hospital Clinic, Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas, University of Barcelona, Spain
    Hepatology 47:1248-56. 2008
  10. doi request reprint Recombinant human manganese superoxide dismutase reduces liver fibrosis and portal pressure in CCl4-cirrhotic rats
    Maeva Guillaume
    Hepatic Haemodynamic Laboratory, Liver Unit, Hospital Clinic, Institut d Investigacions Biomèdiques August Pi i Sunyer IDIBAPS and Ciberehd, University of Barcelona, Spain
    J Hepatol 58:240-6. 2013

Detail Information

Publications134 found, 100 shown here

  1. ncbi request reprint Prevention of variceal rebleeding
    Jaume Bosch
    Hepatic Haemodynamic Laboratory, Liver Unit, Institut de Malalties Digestives, Hospital Clinic, IDIBAPS, University of Barcelona, 08036, Barcelona, Spain
    Lancet 361:952-4. 2003
    ..Endoscopic techniques include band ligation (EBL) and injection sclerotherapy (EIS). Drug approaches are based on non-selective beta blocker with or without isosorbide-5-mononitrate (ISMN)...
  2. ncbi request reprint Recombinant factor VIIa for upper gastrointestinal bleeding in patients with cirrhosis: a randomized, double-blind trial
    Jaime Bosch
    Hospital Clinic, Liver Unit, Barcelona, Spain
    Gastroenterology 127:1123-30. 2004
    ..This trial aimed to determine efficacy and safety of rFVIIa in cirrhotic patients with variceal and nonvariceal UGIB...
  3. ncbi request reprint Current management of portal hypertension
    Jaime Bosch
    Hepatic Hemodynamic Laboratory, Liver Unit, IMD, Hospital Clinic, IDIBAPS, University of Barcelona, Villarroel 170, 08036, Barcelona, Spain
    J Hepatol 38:S54-68. 2003
  4. ncbi request reprint Is treatment with nadolol effective against the growth of small esophageal varices in patients with cirrhosis?
    Jaime Bosch
    Liver Unit, Hospital Clinic, University of Barcelona, Spain
    Nat Clin Pract Gastroenterol Hepatol 2:18-9. 2005
  5. doi request reprint Terutroban, a TP-receptor antagonist, reduces portal pressure in cirrhotic rats
    Eugenio Rosado
    Hepatic Hemodynamic Laboratory, Liver Unit, IMDiM, Hospital Clinic, Institut d Investigacions Biomèdiques August Pi i Sunyer IDIBAPS and Ciberehd, University of Barcelona, Barcelona, Spain
    Hepatology 58:1424-35. 2013
    ..The potential use of terutroban for portal hypertension requires further investigation...
  6. doi request reprint Interaction between NO and COX pathways modulating hepatic endothelial cells from control and cirrhotic rats
    Eugenio Rosado
    Hepatic Hemodynamic Laboratory, Liver Unit, IMDiM, Hospital Clinic, Institut d Investigacions Biomèdiques August Pi i Sunyer IDIBAPS and Ciberehd, University of Barcelona, Barcelona, Spain
    J Cell Mol Med 16:2461-70. 2012
    ..These strategies may have beneficial effects ameliorating the vasoconstrictor/vasodilator imbalance of the intrahepatic circulation of cirrhotic livers...
  7. doi request reprint Hepatic endothelial dysfunction and abnormal angiogenesis: new targets in the treatment of portal hypertension
    Jaume Bosch
    Hepatic Hemodynamic Laboratory, Liver Unit, Hospital Clínic IDIBAPS and Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas, Spain
    J Hepatol 53:558-67. 2010
    ....
  8. doi request reprint Resveratrol improves intrahepatic endothelial dysfunction and reduces hepatic fibrosis and portal pressure in cirrhotic rats
    Marco Di Pascoli
    Hepatic Hemodynamic Laboratory, Liver Unit, Hospital Clinic, Institut d Investigacions Biomèdiques August Pi i Sunyer and Ciberehd, University of Barcelona, Spain
    J Hepatol 58:904-10. 2013
    ..Our study aimed at evaluating the effects of resveratrol on hepatic and systemic hemodynamics, hepatic endothelial dysfunction, and hepatic fibrosis in CCl₄ cirrhotic rats...
  9. doi request reprint Increased oxidative stress in cirrhotic rat livers: A potential mechanism contributing to reduced nitric oxide bioavailability
    Jorge Gracia-Sancho
    Hepatic Hemodynamic Laboratory, Liver Unit, Institut de Malalties Digestives i Metabòliques IMDiM, Hospital Clinic, Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas, University of Barcelona, Spain
    Hepatology 47:1248-56. 2008
    ..Conclusion: Our data show that oxidative stress may contribute to reduced NO bioavailability in cirrhotic livers, supporting the evaluation of O(2) (-) reduction as a potential mechanism to restore NO content...
  10. doi request reprint Recombinant human manganese superoxide dismutase reduces liver fibrosis and portal pressure in CCl4-cirrhotic rats
    Maeva Guillaume
    Hepatic Haemodynamic Laboratory, Liver Unit, Hospital Clinic, Institut d Investigacions Biomèdiques August Pi i Sunyer IDIBAPS and Ciberehd, University of Barcelona, Spain
    J Hepatol 58:240-6. 2013
    ....
  11. doi request reprint Tempol administration, a superoxide dismutase mimetic, reduces hepatic vascular resistance and portal pressure in cirrhotic rats
    Héctor García-Calderó
    Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas, University of Barcelona, Spain
    J Hepatol 54:660-5. 2011
    ..We aimed to evaluate whether a strategy directed to reduce superoxide using tempol, a small membrane permeable SOD-mimetic, is able to modulate intrahepatic nitric oxide content and reduce portal pressure in cirrhotic rats...
  12. ncbi request reprint Prognostic value of acute hemodynamic response to i.v. propranolol in patients with cirrhosis and portal hypertension
    Vincenzo La Mura
    Hepatic Hemodynamic Laboratory, Liver Unit, Hospital Clinic IDIBAPS, University of Barcelona and Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas CIBERehd, Calle Villaroel 170, 08036 Barcelona, Spain
    J Hepatol 51:279-87. 2009
    ..However, two HVPG measurements are needed to evaluate response. This study was aimed at investigating the predictive role of acute HVPG response to i.v. propranolol for bleeding and survival...
  13. ncbi request reprint Cyclooxygenase-1 inhibition corrects endothelial dysfunction in cirrhotic rat livers
    Mariona Graupera
    Hepatic Hemodynamic Laboratory, Liver Unit, Institut Malalties Digestives, Hospital Clinic, Institut d Investigacions Biomediques August Pi i Sunyer, University of Barcelona, Villarroel 170, 08036 Barcelona, Spain
    J Hepatol 39:515-21. 2003
    ..The present study evaluates the role of cyclooxygenase (COX)-derived prostanoids, implicated in the pathogenesis of endothelial dysfunction in other settings, in the pathogenesis of endothelial dysfunction in cirrhotic livers...
  14. ncbi request reprint TIPS versus drug therapy in preventing variceal rebleeding in advanced cirrhosis: a randomized controlled trial
    Angels Escorsell
    Hepatic Hemodynamic Laboratory, Liver Unit, Hospital Clinic, IDIBAPS, Barcelona, Spain
    Hepatology 35:385-92. 2002
    ..This suggests that TIPS should not be used as a first-line treatment, but as a rescue for failures of medical/endoscopic treatments (first-option therapies)...
  15. doi request reprint Large-conductance calcium-activated potassium channels modulate vascular tone in experimental cirrhosis
    Aina Rodriguez-Vilarrupla
    Hepatic Hemodynamic Laboratory, Liver Unit, Institut Malalties Digestives i Metabòliques, Hospital Clinic, Institut d Investigacions Biomediques August Pi i Sunyer, CIBERehd, Barcelona, Spain
    Liver Int 28:566-73. 2008
    ..The aim of this study was to evaluate the role of BK(Ca) channels in the regulation of vascular tone in control (CT) and carbon tetrachloride-cirrhotic (CH) rat livers...
  16. ncbi request reprint Evidence against a role for NADPH oxidase modulating hepatic vascular tone in cirrhosis
    Jorge Gracia-Sancho
    Hepatic Hemodynamic Laboratory, Liver Unit, IMDiM, Hospital Clinic, Ciberehd and Institut d Investigacions Biomèdiques August Pi i Sunyer, University of Barcelona, Spain
    Gastroenterology 133:959-66. 2007
    ..Thus, our aims were to study the molecular and biochemical state of NADPH-oxidase in cirrhotic livers and to investigate its possible role in modulating hepatic vascular tone in cirrhosis...
  17. ncbi request reprint Role of hepatic vein catheterisation and transient elastography in the diagnosis of idiopathic portal hypertension
    Susana Seijo
    Hepatic Hemodynamic Laboratory, Liver Unit, Hospital Clinic, Institut d Investigacions Biomediques August Pi i Sunyer IDIBAPS, University of Barcelona, Spain
    Dig Liver Dis 44:855-60. 2012
    ..This study evaluates specific findings at hepatic vein catheterisation or liver stiffness in idiopathic portal hypertension...
  18. doi request reprint Insulin resistance in patients with cirrhosis and portal hypertension
    Eva Erice
    Hepatic Hemodynamic Laboratory, Liver Unit, Hospital Clinic, Institut d Investigacions Biomediques August Pi i Sunyer, University of Barcelona, Barcelona, Spain
    Am J Physiol Gastrointest Liver Physiol 302:G1458-65. 2012
    ..In nondiabetic patients with cirrhosis, HOMA-2 index is directly associated with the presence of CSPH and indirectly with varices, but does not allow either grading HVPG or predicting its response to propranolol...
  19. ncbi request reprint A randomized unblinded pilot study comparing albumin versus hydroxyethyl starch in spontaneous bacterial peritonitis
    Javier Fernandez
    Liver Unit, IMDM and IDIBAPS, Hospital Clinic, University of Barcelona, Spain
    Hepatology 42:627-34. 2005
    ..This effect is due not only to volume expansion but also to an action on the peripheral arterial circulation...
  20. ncbi request reprint Propranolol plus placebo versus propranolol plus isosorbide-5-mononitrate in the prevention of a first variceal bleed: a double-blind RCT
    Juan Carlos Garcia-Pagan
    Hepatic Hemodynamic Laboratory, Liver Unit, Institut de Malaties Digestives, Hospital Clinic, Institut d Investigacions Biomediques August Pi i Sunyer, University of Barcelona, Barcelona, Spain
    Hepatology 37:1260-6. 2003
    ..However, the long-term use of this combination drug therapy is safe and may be an alternative in clinical conditions associated with a greater risk of bleeding...
  21. doi request reprint Leptin receptor blockade reduces intrahepatic vascular resistance and portal pressure in an experimental model of rat liver cirrhosis
    María Gabriela Delgado
    Barcelona Hepatic Hemodynamic Laboratory, Liver Unit, Hospital Clinic, Villarroel 170, 08036 Barcelona, Spain
    Am J Physiol Gastrointest Liver Physiol 305:G496-502. 2013
    ..In conclusion, the present study shows that blockade of the leptin signaling pathway in cirrhosis significantly reduces portal pressure. This effect is probably due to a nitric oxide-mediated reduction in the hepatic vascular tone...
  22. ncbi request reprint Effects of propranolol on venous compliance in conscious rats with pre-hepatic portal hypertension
    Victoria Andreu
    Hepatic Hemodynamic Lab, Liver Unit, Institut Clínic de Malalties Digestives i Metabolisme, Hospital Clinic de Barcelona, Institut de Investigacions Biomèdiques August Pi i Sunyer IDIBAPS, University of Barcelona, Barcelona, Spain
    J Hepatol 44:1040-5. 2006
    ..To investigate venous compliance (VC) in conscious partial portal vein ligated rats (PPVL) and the effect of propranolol on VC...
  23. doi request reprint Acute and long-term effects of inhaled iloprost in portopulmonary hypertension
    Maria Teresa Melgosa
    Department of Pulmonary Medicine, University of Barcelona, Barcelona, Spain
    Liver Transpl 16:348-56. 2010
    ..Its long-term use may provide sustained improvements in symptoms and exercise tolerance in some patients with PoPH. A randomized, controlled trial is warranted to establish its clinical role in this serious condition...
  24. ncbi request reprint Sinusoidal endothelial COX-1-derived prostanoids modulate the hepatic vascular tone of cirrhotic rat livers
    Mariona Graupera
    Hepatic Hemodynamic Laboratory, Hospital Clinic, Villarroel 170, 08036 Barcelona, Spain
    Am J Physiol Gastrointest Liver Physiol 288:G763-70. 2005
    ..Despite abundant hepatic COX-2 expression, the increased response to Mtx of cirrhotic livers is mainly dependent of COX-1. Upregulation of COX-1 in cirrhotic SEC may be responsible for the hyperesponse to Mtx...
  25. doi request reprint Generation of 5 and 17 kDa human growth hormone fragments through limited proteolysis
    Gerard Such-Sanmartín
    Bio analysis group, Neuropsychopharmacology Program, Municipal Institute for Medical Research Hospital del Mar, Parque de Investigación Biomédica de Barcelona, Barcelona, Spain
    Growth Factors 27:255-64. 2009
    ..To evaluate this hypothesis, the activity of several endo-proteases on the 22 kDa hGH protein has been evaluated...
  26. doi request reprint A MELD-based model to determine risk of mortality among patients with acute variceal bleeding
    Enric Reverter
    Hepatic Hemodynamic Laboratory, Liver Unit, Hospital Clinic, Institut d Investigacions Biomediques August Pi i Sunyer, University of Barcelona, Barcelona, Spain Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas, Barcelona, Spain
    Gastroenterology 146:412-19.e3. 2014
    ..We aimed to improve determination of risk for patients with AVB...
  27. doi request reprint Efficacy and safety of anticoagulation on patients with cirrhosis and portal vein thrombosis
    María Gabriela Delgado
    Hepatic Hemodynamic Laboratory, Liver Unit, Institut de Malalties Digestives i Metaboliques, Hospital Clínic Institut de Investigacions Biomèdiques August Pi i Sunyer IDIBAPS, University of Barcelona, Barcelona, Spain
    Clin Gastroenterol Hepatol 10:776-83. 2012
    ..We evaluated this therapy in a large series of patients with cirrhosis and non-neoplastic PVT...
  28. doi request reprint PPARα activation improves endothelial dysfunction and reduces fibrosis and portal pressure in cirrhotic rats
    Aina Rodriguez-Vilarrupla
    University of Barcelona, Spain
    J Hepatol 56:1033-9. 2012
    ..This study aims at evaluating the effects of PPARα activation with fenofibrate on hepatic and systemic hemodynamics, hepatic endothelial dysfunction, and hepatic fibrosis in CCl(4)-cirrhotic rats...
  29. doi request reprint Hypercoagulability in patients with chronic noncirrhotic portal vein thrombosis
    Sebastian Raffa
    Hepatic Hemodynamic Laboratory, Liver Unit, Hospital Clinic, Institut d Investigacions Biomediques August Pi i Sunyer IDIBAPS, University of Barcelona and Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas CIBERehd, Barcelona, Spain
    Clin Gastroenterol Hepatol 10:72-8. 2012
    ..We investigated the significance of these results...
  30. doi request reprint Angiogenesis in liver disease
    Mercedes Fernandez
    Hepatic Hemodynamic Laboratory, Liver Unit, Hospital Clinic IDIBAPS, University of Barcelona, Barcelona, Spain
    J Hepatol 50:604-20. 2009
    ....
  31. doi request reprint Growth hormone abuse and biological passport: is mannan-binding lectin a complementary candidate?
    Gerard Such-Sanmartín
    Bio Analysis Research Group, Neuropsychopharmacology Program, IMIM Hospital del Mar, PRBB, Barcelona, Spain
    Clin J Sport Med 21:441-3. 2011
    ..As a potential biomarker, mannan-binding lectin (MBL), which is reported to respond to recombinant GH (rGH) administration, is evaluated here...
  32. ncbi request reprint Total effective vascular compliance in patients with cirrhosis. Effects of propranolol
    Victoria Andreu
    Liver Unit, Hospital Clinic, Villarroel 170, 08036, Barcelona, Spain
    J Hepatol 36:356-61. 2002
    ..Total effective vascular compliance (TEVC), may be increased in cirrhosis. However, its significance is unclear...
  33. doi request reprint Metabolomics discloses potential biomarkers for the noninvasive diagnosis of idiopathic portal hypertension
    Susana Seijo
    Liver Unit, Hepatic Hemodynamic Laboratory, Institut de Malalties Digestives i Metaboliques, Hospital Clínic Institut de Investigacions Biomèdiques August Pi i Sunyer IDIBAPS, Barcelona, Spain
    Am J Gastroenterol 108:926-32. 2013
    ..Requiring ruling-out other causes of portal hypertension it is frequently misdiagnosed. This study evaluates whether using high-throughput techniques there is a metabolomic profile allowing a noninvasive diagnosis of IPH...
  34. ncbi request reprint Sonography of the caudate vein: value in diagnosing Budd-Chiari syndrome
    Xavier Bargallo
    Department of Radiology, Hospital Clinic, C Villarroel, 170, Barcelona 08036, Spain
    AJR Am J Roentgenol 181:1641-5. 2003
    ..The aim of this study was to evaluate the usefulness of sonography in measuring the caudate vein and lobe when diagnosing Budd-Chiari syndrome...
  35. ncbi request reprint Idiopathic portal hypertension: Natural history and long-term outcome
    Sith Siramolpiwat
    Barcelona Hepatic Hemodynamic Laboratory, Liver Unit, Institut de Malalties Digestives i Metaboliques, Hospital Clínic Institut de Investigacions Biomèdiques August Pi i Sunyer IDIBAPS, Barcelona, Spain
    Hepatology 59:2276-85. 2014
    ..PVT is a frequent complication, particularly in those with HIV infection. Despite several complications, overall survival of patients with IPH is considerably good. (Hepatology 2014;59:2276-2285). ..
  36. ncbi request reprint Analysis of urinary human growth hormone (hGH) using hydrogel nanoparticles and isoform differential immunoassays after short recombinant hGH treatment: preliminary results
    Jaume Bosch
    Bioanalysis Group IMIM Parc Salut Mar and Department of Experimental and Health Sciences, Universitat Pompeu Fabra, Barcelona Biomedical Research Park PRBB, Barcelona, Spain
    J Pharm Biomed Anal 85:194-7. 2013
    ..The use of nanoparticles appears to open the possibility of assessing rhGH misuse in urine...
  37. doi request reprint Portal cholangiopathy: radiological classification and natural history
    Elba Llop
    Hepatic Hemodynamic Laboratory, Liver Unit, Hospital Clinic, Barcelona 08036, Spain
    Gut 60:853-60. 2011
    ..This study investigated the relationship between cholangiographic abnormalities and clinical symptoms and their evolution over time...
  38. doi request reprint Hyponatremia in patients treated with terlipressin for severe gastrointestinal bleeding due to portal hypertension
    Elsa Solá
    Liver Unit, Hospital Clinic, University of Barcelona, Barcelona, Catalunya, Spain
    Hepatology 52:1783-90. 2010
    ....
  39. pmc Identification and functional characterization of the hepatic stellate cell CD38 cell surface molecule
    Sandra March
    Immunology Unit, Department of Cellular Biology and Pathology, Medical School, University of Barcelona, Barcelona, Spain
    Am J Pathol 170:176-87. 2007
    ..Collectively, our data suggest that CD38 can act as a regulator of HSC activation and effector functions...
  40. doi request reprint Impact of deep sedation on the accuracy of hepatic and portal venous pressure measurements in patients with cirrhosis
    Enric Reverter
    Hepatic Hemodynamic Laboratory, Liver Unit, Hospital Clinic, IDIBAPS Institut d Investigacions Biomèdiques August Pi i Sunyer, University of Barcelona, Barcelona, Spain Ciberehd Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas, Barcelona, Spain
    Liver Int 34:16-25. 2014
    ..In specific circumstances, (children, agitated patients, TIPS placement) deep sedation is required. This study aims to assess the impact of deep sedation on the accuracy of hepatic/portal pressure measurements...
  41. doi request reprint Growth hormone in sport: beyond Beijing 2008
    Jordi Segura
    Bioanalysis and Analytical Services Research Group, Institut Municipal d Investigació Mèdica IMIM Hospital del Mar, Universitat Pompeu Fabra, Barcelona, Spain
    Ther Drug Monit 31:3-13. 2009
    ..In parallel with the new types of abuse, which will surely emerge in the near future, the research and development for the improvement of the analytical detection of GH itself will continue...
  42. ncbi request reprint Current concepts on the pathophysiology of portal hypertension
    Aina Rodriguez-Vilarrupla
    Hepatic Hemodynamic Laboratory, Liver Unit Institut Malalties Digestives I Metabòliques, Hospital Clinic, Institut d Investigacions Biomediques August Pi i Sunyer, CIBER Enfermedades Hepáticas y Digestivas, University of Barcelona, Spain
    Ann Hepatol 6:28-36. 2007
    ..This splanchnic arteriolar vasodilatation is a multifactorial phenomenon, which may involve neurogenic, humoral and local mechanisms...
  43. ncbi request reprint Transient elastography for diagnosis of advanced fibrosis and portal hypertension in patients with hepatitis C recurrence after liver transplantation
    José A Carrión
    Liver Unit, Institut de Malalties Digestives, Centre de Diagnòstic per l Imatge, Hospital Clinic, Institut d Investigacions Biomediques August Pi i Sunyer IDIBAPS, Barcelona, Spain
    Liver Transpl 12:1791-8. 2006
    ..In conclusion, determination of liver stiffness is an extremely valuable tool to assess the severity of HCV recurrence after LT and in reducing the need of follow-up liver biopsies...
  44. ncbi request reprint Effect of intravenous albumin on systemic and hepatic hemodynamics and vasoactive neurohormonal systems in patients with cirrhosis and spontaneous bacterial peritonitis
    Javier Fernandez
    Liver Unit, IMD, IDIBAPS, Hospital Clinic, University of Barcelona, Barcelona, Spain
    J Hepatol 41:384-90. 2004
    ..Albumin administration prevents renal failure and improves survival in spontaneous bacterial peritonitis. This study characterizes the mechanisms of action of albumin in this condition...
  45. doi request reprint Growth hormone secretagogues: out of competition
    Armand Pinyot
    Bioanalysis Group, Neurosciences Research Program, Municipal Institute for Medical Research Hospital del Mar, 08003 Barcelona, Spain
    Anal Bioanal Chem 402:1101-8. 2012
    ..5 h, and results were confirmed by comparison with a dedicated LC-MS quantification of the intact compound...
  46. ncbi request reprint Increasing intra-abdominal pressure increases pressure, volume, and wall tension in esophageal varices
    Angels Escorsell
    Hepatic Hemodynamics Laboratory, Liver Unit, IMD, Hospital Clinic, Barcelona, Spain
    Hepatology 36:936-40. 2002
    ..Increases in IAP may contribute to the progressive dilatation that precedes the rupture of the varices in portal hypertension...
  47. ncbi request reprint Increased CD11b neutrophil expression in Budd-Chiari syndrome or portal vein thrombosis secondary to polycythaemia vera
    Alberto Alvarez-Larran
    Haematology Department, Institute of Haematology and Oncology, Hospital Clinic, IDIBAPS, University of Barcelona, Villaroel 170, 08036 Barcelona, Spain
    Br J Haematol 124:329-35. 2004
    ..05). These results support a role for neutrophils in BCS/PVT secondary to PV and indicate that neutrophil CD11b expression could be of use for PV screening in BCS/PVT patients...
  48. ncbi request reprint Management of gastrointestinal bleeding in patients with cirrhosis of the liver
    Jaime Bosch
    Liver Unit, Hospital Clinic, University of Barcelona, Spain
    Semin Hematol 41:8-12. 2004
    ..Specific sections on gastric varices and portal hypertensive gastropathy are included...
  49. ncbi request reprint Inhibition of VEGF receptor-2 decreases the development of hyperdynamic splanchnic circulation and portal-systemic collateral vessels in portal hypertensive rats
    Mercedes Fernandez
    Hepatic Hemodynamic Laboratory, Liver Unit, Institut d Investigacions Biomediques August Pi i Sunyer, Hospital Clinic, University of Barcelona, Villarroel 170, 08036 Barcelona, Spain
    J Hepatol 43:98-103. 2005
    ..To determine whether this process is angiogenesis-dependent, we assessed the effects of SU5416, a specific inhibitor of VEGF receptor-2, in portal hypertensive rats...
  50. ncbi request reprint Effect of transjugular intrahepatic portosystemic shunt on pulmonary gas exchange in patients with portal hypertension and hepatopulmonary syndrome
    Graciela Martinez-Palli
    Servei d Anestesiologia i Reanimacio Hospital Clinic, Institut d Investigacions Biomediques August Pi i Sunyer IDIBAPS, Universitat de Barcelona, Barcelona, Spain
    World J Gastroenterol 11:6858-62. 2005
    ..To assess the impact of transjugular intrahepatic portosystemic shunt (TIPS) on pulmonary gas exchange and to evaluate the use of TIPS for the treatment of hepatopulmonary syndrome ( HPS )...
  51. ncbi request reprint Noncirrhotic portal vein thrombosis exhibits neuropsychological and MR changes consistent with minimal hepatic encephalopathy
    Beatriz Minguez
    Servei de Medicina Interna Hepatologia, Hospital Universitari Vall d Hebron, Universitat Autonoma de Barcelona, Barcelona, Spain
    Hepatology 43:707-14. 2006
    ..These disturbances, which include signs of increase in brain water and a compensatory osmotic response (decrease in brain myo-inositol), appear to be secondary to brain exposure to ammonia induced by portal-systemic shunting...
  52. ncbi request reprint Left ventricular hypertrophy in rats with biliary cirrhosis
    Javier Inserte
    Servicio de Cardiologia, Hospital Universitari Vall d Hebron, Barcelona, Spain
    Hepatology 38:589-98. 2003
    ..This observation could be relevant to patients with cirrhosis...
  53. ncbi request reprint Cyclooxygenase-derived products modulate the increased intrahepatic resistance of cirrhotic rat livers
    Mariona Graupera
    Hepatic Hemodynamic Laboratory, Liver Unit, Institut Malalties Digestives, University of Barcelona, Spain
    Hepatology 37:172-81. 2003
    ..SQ 29,548 also corrected the hyperresponse of cirrhotic livers to methoxamine. In conclusion, COX-derived prostanoids, mainly TXA(2), play a major role in regulating the response of cirrhotic livers to methoxamine...
  54. doi request reprint TIPS for Budd-Chiari syndrome: long-term results and prognostics factors in 124 patients
    Juan Carlos Garcia-Pagan
    Hepatic Hemodynamic Laboratory, Liver Unit Hospital Clínic, IDIBAPS and Ciberehd, Barcelona, Spain
    Gastroenterology 135:808-15. 2008
    ..However, the influence of TIPS on patient survival and factors that predict the outcome of TIPS in BCS patients remain unknown...
  55. doi request reprint Atrophy of mesenteric sympathetic innervation may contribute to splanchnic vasodilation in rat portal hypertension
    Mar Coll
    Liver Diseases Laboratory, Liver Unit, Department of Internal Medicine, Institut de Recerca Hospital Vall d Hebron, Universitat Autonoma de Barcelona, Barcelona, Spain
    Liver Int 30:593-602. 2010
    ..We also attempted to localize the origin of mRNA of specific adrenergic genes...
  56. ncbi request reprint Vascular deterioration in cirrhosis: the big picture
    Jaime Bosch
    Hepatic Hemodynamic Laboratory, Liver Unit, Hospital Clinic IDIBAPS, University of Barcelona and Centro de Investigación Biomédica de Enfermedades Hepáticas y Digestivas Ciberehd, Barcelona, Spain
    J Clin Gastroenterol 41:S247-53. 2007
    ..Advances in the knowledge of the mechanisms of these abnormalities have disclosed new targets for therapy and ultimately improved survival...
  57. doi request reprint Noninvasive prediction of clinically significant portal hypertension and esophageal varices in patients with compensated liver cirrhosis
    Annalisa Berzigotti
    Hepatic Hemodynamic Laboratory, Liver Unit, Institut d Investigacions Biomèdiques August Pi i Sunyer IDIBAPS and Centro de Investigación Biomèdica en Red de Enfermedades Hepáticas y Digestivas CIBERehd, University of Barcelona, Barcelona, Spain
    Am J Gastroenterol 103:1159-67. 2008
    ..We aimed to develop a model based on noninvasive variables for the prediction of clinically significant portal hypertension (CSPH) and of esophageal varices (EV) in patients with compensated liver disease...
  58. ncbi request reprint Anti-VEGF receptor-2 monoclonal antibody prevents portal-systemic collateral vessel formation in portal hypertensive mice
    Mercedes Fernandez
    Hepatic Hemodynamic Laboratory, Liver Unit, Insitut d Investigacions Biomediques August Pi i Sunyer, Hospital Clinic, Universityof Barcelona, Spain
    Gastroenterology 126:886-94. 2004
    ..The high relevance of these collateral vessels prompted us to investigate the mechanism underlying its formation in a murine model of portal hypertension...
  59. doi request reprint Recombinant factor VIIa for variceal bleeding in patients with advanced cirrhosis: A randomized, controlled trial
    Jaime Bosch
    Hepatic Hemodynamic Laboratory, Hospital Clinic and Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas CIBEREHD, University of Barcelona, Spain
    Hepatology 47:1604-14. 2008
    ..A marked heterogeneity in the failure rate in all treatment groups was observed across participating centers. Adverse events, including overall thromboembolic events, were comparable between groups...
  60. doi request reprint Early use of TIPS in patients with cirrhosis and variceal bleeding
    Juan Carlos Garcia-Pagan
    Hepatic Hemodynamic Laboratory, Liver Unit, Institut de Malalties Digestives i Metaboliques, University of Barcelona, Barcelona, Spain
    N Engl J Med 362:2370-9. 2010
    ..This study evaluated the earlier use of TIPS in such patients...
  61. ncbi request reprint The treatment of acute variceal bleeding
    Juan G Abraldes
    Hepatic Hemodynamic Laboratory, Liver Unit, Institut Malalties Digestives i Metabòliques, Hospital Clinic, University of Barcelona, Barcelona, Spain
    J Clin Gastroenterol 41:S312-7. 2007
    ..This paper reviews the most recent advancements in the general management and hemostatic treatments of acute variceal bleeding...
  62. ncbi request reprint P-selectin mediates leukocyte rolling in concanavalin-A-induced hepatitis
    Sandra March
    Immunology Unit, Department of Cellular Biology and Pathology, Medical School, University of Barcelona, Villaroel 170, Barcelona, Spain
    Liver Int 25:1053-60. 2005
    ..The aim of the present study was to evaluate the role of P-selectin on leukocyte-endothelial interactions within the hepatic microvasculature in response to Con-A...
  63. ncbi request reprint The resistance of the cirrhotic liver: a new target for the treatment of portal hypertension. 1985
    Juan Carlos Garcia-Pagan
    Hepatic Hemodynamic Lab Liver Unit, Institut de Malalties Digestives, Hospital Clinic IDIBAPS University of Barcelona, Villarroel 170, Barcelona 08036, Spain
    J Hepatol 40:887-90. 2004
  64. ncbi request reprint Hemostatic effect of activated recombinant factor VII (rFVIIa) in liver disease: studies in an in vitro model
    Raul Tonda
    Servicio de Hemoterapia Hemostasia, Hospital Clinic, Facultad de Medicina, IDIBAPS, Calle Villarroel 170, Barcelona 08036, Spain
    J Hepatol 39:954-9. 2003
    ..The exact mechanism of action of rFVIIa in this clinical condition is unknown. We have explored effects of rFVIIa on hemostasis in cirrhotic patients using an in vitro perfusion technique...
  65. doi request reprint The management of portal hypertension: rational basis, available treatments and future options
    Jaime Bosch
    Hepatic Hemodynamic Laboratory, Liver Unit, Institut d Investigacions Biomediques August Pi i Sunyer IDIBAPS, University of Barcelona, Hospital Clinic, C Villarroel 170, 08036 Barcelona, Spain
    J Hepatol 48:S68-92. 2008
    ....
  66. doi request reprint A specialized, nurse-run titration clinic: a feasible option for optimizing beta-blockade in non-clinical trial patients
    Puneeta Tandon
    Hospital Clinic, University of Barcelona, Barcelona, Spain
    Am J Gastroenterol 105:1917-21. 2010
    ..We aimed to evaluate the dosing and tolerance of BBs achievable in a specialized, nurse-run BB titration clinic with non-trial participants...
  67. doi request reprint Simvastatin lowers portal pressure in patients with cirrhosis and portal hypertension: a randomized controlled trial
    Juan G Abraldes
    Hepatic Hemodynamic Laboratory, Liver Unit, Hospital Clinic, Institut d Investigacions Biomediques August Pi i Sunyer, University of Barcelona, Spain
    Gastroenterology 136:1651-8. 2009
    ..This randomized controlled trial evaluated the effects of continuous simvastatin administration on the hepatic venous pressure gradient (HVPG) and its safety in patients with cirrhosis and portal hypertension...
  68. ncbi request reprint Nitric oxide and portal hypertension
    Juan González-Abraldes
    Hepatic Hemodynamic Laboratory, Liver Unit, Hospital Clinic, IDIBAPS, University of Barcelona, Spain
    Metab Brain Dis 17:311-24. 2002
    ..Moreover, it cannot be ruled out that NO blockade may have a deleterious action on cirrhosis progression, which raises caution about their use in patients with cirrhosis...
  69. ncbi request reprint Potential role of antioxidants in the treatment of portal hypertension
    Aina Rodriguez-Vilarrupla
    Hepatic Hemodynamic Laboratory, Liver Unit, Institut Malalties Digestives i Metabòliques, Hospital Clinic, Institut d Investigacions Biomediques August Pi i Sunyer IDIBAPS, University of Barcelona, Barcelona, Spain
    J Hepatol 46:193-7. 2007
  70. ncbi request reprint Characterisation of the 5 kDa growth hormone isoform
    Gerard Such-Sanmartín
    Pharmacology Research Unit, Municipal Institute for Medical Research IMIM, Barcelona, Spain
    Growth Factors 26:152-62. 2008
    ..This isoform can be easily obtained by solid phase synthesis methods. Our objective in this study is to describe this procedure in detail and to provide structural information of the protein...
  71. ncbi request reprint Right atrial pressure is not adequate to calculate portal pressure gradient in cirrhosis: a clinical-hemodynamic correlation study
    Vincenzo La Mura
    Hepatic Hemodynamic Laboratory, Liver Unit, Hospital Clinic, Institut d Investigacions Biomediques August Pi i Sunyer, University of Barcelona and Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas CIBERehd, Barcelona, Spain
    Hepatology 51:2108-16. 2010
    ..In our TIPS patients, 20% had a PCG < or =12 mm Hg and a PAG >12 mm Hg, which may have induced unnecessary overdilation of the TIPS...
  72. doi request reprint The somatostatin analogue octreotide inhibits angiogenesis in the earliest, but not in advanced, stages of portal hypertension in rats
    Marc Mejias
    Hepatic Hemodynamic Laboratory, Liver Unit, Institut d Investigacions Biomediques August Pi i Sunyer IDIBAPS, Barcelona, Spain
    J Cell Mol Med 12:1690-9. 2008
    ..Somatostatin and its analogues, like octreotide, have been shown to be powerful inhibitors of experimental angiogenesis...
  73. ncbi request reprint Ascorbic acid improves the intrahepatic endothelial dysfunction of patients with cirrhosis and portal hypertension
    Manuel Hernandez-Guerra
    Hepatic Hemodynamic Laboratory, Liver Unit, Institut de Malalties Digestives, Hospital Clinic, Institut d Investigaciones Biomèdiques August Pi i Sunyer, Barcelona, Spain
    Hepatology 43:485-91. 2006
    ..These results encourage the performance of further studies testing antioxidants as adjunctive therapy in the treatment of portal hypertension...
  74. doi request reprint NCX-1000, a nitric oxide-releasing derivative of UDCA, does not decrease portal pressure in patients with cirrhosis: results of a randomized, double-blind, dose-escalating study
    Annalisa Berzigotti
    Hepatic Hemodynamics Laboratory, Hospital Clinic IDIBAPS, University of Barcelona, Barcelona, Spain
    Am J Gastroenterol 105:1094-101. 2010
    ..This study was aimed at testing the efficacy and tolerability of this compound in patients with cirrhosis and portal hypertension...
  75. doi request reprint Apelin signaling modulates splanchnic angiogenesis and portosystemic collateral vessel formation in rats with portal hypertension
    Carolina Tiani
    Hepatic Hemodynamic Laboratory, Liver Unit, Institut d Investigacions Biomediques August Pi i Sunyer IDIBAPS, Hospital Clinic, CIBERehd, University of Barcelona, Villarroel 170, 08036 Barcelona, Spain
    J Hepatol 50:296-305. 2009
    ..The apelin/APJ signaling pathway plays a crucial role in angiogenesis. Therefore, we determined whether the apelin system modulates angiogenesis-driven processes in portal hypertension...
  76. ncbi request reprint Medical management of variceal bleeding in patients with cirrhosis
    Juan G Abraldes
    Hospital Clinic, Institut d Investigactions Biomèdiques August Pi i Sunyer IDIBAPS, University of Barcelona, Barcelona, Spain
    Can J Gastroenterol 18:109-13. 2004
    ..Administration of recombinant activated factor VII may decrease the number of treatment failures among patients with advanced liver failure (Child-Pugh class B and C)...
  77. doi request reprint Beneficial effects of sorafenib on splanchnic, intrahepatic, and portocollateral circulations in portal hypertensive and cirrhotic rats
    Marc Mejias
    Hepatic Hemodynamic Laboratory, Liver Unit, Hospital Clinic, CIBERehd, Barcelona, Spain
    Hepatology 49:1245-56. 2009
    ..Notably, beneficial effects of sorafenib against tissue damage and inflammation were also observed in splanchnic organs...
  78. ncbi request reprint Idiopathic portal hypertension in patients with HIV infection treated with highly active antiretroviral therapy
    Pik Eu Chang
    Hepatic Hemodynamic Laboratory, Liver Unit, Institut de Malalties Digestives i Metaboliques, Hospital Clinic, Institut d Investigacions Biomediques August Pi i Sunyer, Barcelona, Spain
    Am J Gastroenterol 104:1707-14. 2009
    ..We describe for the first time the hepatic and systemic hemodynamic profile, liver stiffness, and histological features of eight patients with HIV-related IPH...
  79. ncbi request reprint The management of portal hypertension
    Juan G Abraldes
    Hepatic Hemodynamic Laboratory, Liver Unit, ICMDM, Hospital Clinic, IDIBAPS, University of Barcelona, Villaroel 170 08036, Barcelona, Spain
    Clin Liver Dis 9:685-713, vii. 2005
    ..This article highlights treatment modalities in use for managing portal hypertension and those that may be available in the future...
  80. pmc NAD(P)H oxidase modulates angiogenesis and the development of portosystemic collaterals and splanchnic hyperaemia in portal hypertensive rats
    Bernhard Angermayr
    Hepatic Hemodynamic Laboratory, Liver Unit, Hospital Clinic, Institut d Investigacions, Biomediques August Pi i Sunyer, University of Barcelona, Barcelona, Spain
    Gut 56:560-4. 2007
    ..Therefore, it could be possible that activated NAD(P)H oxidases modulate angiogenesis in portal hypertension...
  81. ncbi request reprint Pharmacological reduction of portal pressure and long-term risk of first variceal bleeding in patients with cirrhosis
    Juan Turnes
    Hepatic Hemodynamic Laboratory, Liver Unit, Institut de Malalties Digestives, Hospital Clinic, IDIBAPS, University of Barcelona, Villaroel 170, 08036 Barcelona, Spain
    Am J Gastroenterol 101:506-12. 2006
    ..The aim of this study was to evaluate whether this protective effect is maintained in the long term and if it extends to other portal hypertension complications...
  82. ncbi request reprint Hepatic venous pressure gradient identifies patients at risk of severe hepatitis C recurrence after liver transplantation
    Alejandro Blasco
    Liver Unit, Institut de Malalties Digestives, Hospital Clinic, Institut d Investigacions Biomediques August Pi i Sunyer, Barcelona, Spain
    Hepatology 43:492-9. 2006
    ..80), an HVPG of 6 mm Hg or greater was extremely accurate at identifying patients at risk of disease progression (AUC: 0.96). In conclusion, HVPG determination is a valuable tool for follow-up in patients with HCV recurrence after LT...
  83. ncbi request reprint Reversal of portal hypertension and hyperdynamic splanchnic circulation by combined vascular endothelial growth factor and platelet-derived growth factor blockade in rats
    Mercedes Fernandez
    Hepatic Hemodynamic Laboratory, Liver Unit, Institut d Investigacions Biomediques August Pi i Sunyer IDIBAPS, Hospital Clinic, CIBERehd, Universitat de Barcelona, Barcelona, Spain
    Hepatology 46:1208-17. 2007
    ..Portosystemic collateralization was reduced as well...
  84. ncbi request reprint Efficacy of antiviral therapy on hepatitis C recurrence after liver transplantation: a randomized controlled study
    José A Carrión
    Liver Unit, Institut de Malalties Digestives, Hospital Clinic, Ciberehd and IDIBAPS, University of Barcelona, Barcelona, Spain
    Gastroenterology 132:1746-56. 2007
    ..Recurrence of hepatitis C virus (HCV) infection is a relevant problem of liver transplantation programs. We evaluated the effect of antiviral therapy on disease progression in 81 HCV-infected liver transplantation recipients...
  85. ncbi request reprint TIPS is a useful long-term derivative therapy for patients with Budd-Chiari syndrome uncontrolled by medical therapy
    Antonia Perello
    Hepatic Hemodynamic Laboratory, Liver Unit, Institut de Malalties Digestives, University of Barcelona, Barcelona, Catalunya, Spain
    Hepatology 35:132-9. 2002
    ..In conclusion, in patients with BCS uncontrolled with medical therapy, TIPS is a highly effective technique that is associated with long-term survival...
  86. ncbi request reprint Heme oxygenase attenuates oxidative stress and inflammation, and increases VEGF expression in portal hypertensive rats
    Bernhard Angermayr
    Liver Unit, Hepatic Hemodynamic Laboratory, Institut d Investigacions Biomediques August Pi i Sunyer, Hospital Clinic, University of Barcelona, Villarroel 170, 08036 Barcelona, Spain
    J Hepatol 44:1033-9. 2006
    ..In this study, we determined the role of heme oxygenase-1 on oxidative stress, inflammation, angiogenesis, and splanchnic hemodynamics in rats with portal hypertension induced by partial portal vein ligation...
  87. ncbi request reprint Endoscopic band ligation in the treatment of portal hypertension
    Juan Carlos Garcia-Pagan
    Hepatic Hemodynamic Laboratory, Liver Unit, Hospital Clinic, University of Barcelona, Spain
    Nat Clin Pract Gastroenterol Hepatol 2:526-35. 2005
    ..EBL, in combination with vasoactive drugs, is the recommended form of therapy for acute esophageal variceal bleeding; however, endoscopic injection sclerotherapy can be used in the acute setting if EBL is technically difficult...
  88. doi request reprint Three-day tetrahydrobiopterin therapy increases in vivo hepatic NOS activity and reduces portal pressure in CCl4 cirrhotic rats
    Vasilica Matei
    Hepatic Hemodynamic Laboratory, Liver Unit, Institut de Malalties Digestives i Metaboliques, Hospital Clinic, Institut d Investigacions Biomediques August Pi i Sunyer IDIBAPS, Villarroel 170, 08036 Barcelona, Spain
    J Hepatol 49:192-7. 2008
    ..The main aim of the study was to evaluate the effect of tetrahydrobiopterin supplementation in portal pressure in CCl4 cirrhotic rats...
  89. ncbi request reprint Ultrasonographic evaluation of liver surface and transient elastography in clinically doubtful cirrhosis
    Annalisa Berzigotti
    Hepatic Hemodynamic Laboratory, Liver Unit, Barcelona, Spain
    J Hepatol 52:846-53. 2010
    ..We aimed to examine the diagnostic value of these methods in patients with a suspicion but not a definite diagnosis of cirrhosis...
  90. doi request reprint Hepatic expression of CXC chemokines predicts portal hypertension and survival in patients with alcoholic hepatitis
    Marlene Dominguez
    Liver Unit, Hospital Clinic, Institut d Investigacions Biomediques August Pi i Sunyer, Ciber de Enfermedades Hepaticas y Digestivas, Barcelona, Catalonia, Spain
    Gastroenterology 136:1639-50. 2009
    ..We performed a prospective study to associate hepatic expression of the CXC subfamily of chemokines with histology findings and prognosis of patients with AH...
  91. ncbi request reprint Influence of beta-2 adrenergic receptor gene polymorphism on the hemodynamic response to propranolol in patients with cirrhosis
    Juan Turnes
    Hepatic Hemodynamic Laboratory, Institut de Malalties Digestives i Metaboliques, Hospital Clinic, IDIBAPS, Barcelona, Spain
    Hepatology 43:34-41. 2006
    ..However, HVPG reduction cannot be predicted from polymorphism analysis. Patients with the Gly16-Glu/Gln27 haplotypes may benefit from the association of hepatic vasodilators to propranolol therapy...
  92. ncbi request reprint [Vasoactive drugs for the treatment of bleeding esophageal varices]
    Jaime Bosch
    Liver Unit, IMD, Hospital Clinic et IDIBAPS, Universite de Barcelone, Casanova, 143, 08036 Barcelone
    Gastroenterol Clin Biol 28:B186-9. 2004
  93. ncbi request reprint Portal hypertension-related complications after acute portal vein thrombosis: impact of early anticoagulation
    Juan Turnes
    Hepatic Hemodynamic Laboratory, Institut Malalties Digestives i Metabòliques, Hospital Clinic, Institut d Investigacions Biomediques August Pi i Sunyer, Barcelona, Spain
    Clin Gastroenterol Hepatol 6:1412-7. 2008
    ..Acute portal vein thrombosis (APVT) is a rare disorder that causes chronic portal hypertension if recanalization is not obtained. However, response to anticoagulation and long-term prognosis of APVT are not well-defined...
  94. doi request reprint Relevance of the mTOR signaling pathway in the pathophysiology of splenomegaly in rats with chronic portal hypertension
    Marc Mejias
    Liver Unit, Institute of Biomedical Research IDIBAPS, CIBERehd, Hospital Clinic, University of Barcelona, Villarroel 170, Barcelona, Spain
    J Hepatol 52:529-39. 2010
    ..This study characterizes the pathogenetic mechanisms leading to spleen enlargement in portal hypertensive rats and focuses on mTOR pathway as a potential modulator of splenomegaly in portal hypertension...
  95. ncbi request reprint Hepatic venous pressure gradient and prognosis in patients with acute variceal bleeding treated with pharmacologic and endoscopic therapy
    Juan G Abraldes
    Hepatic Hemodynamic Laboratory, Liver Unit, IMDiM, Hospital Clinic, Institut d Investigacions Biomediques August Pi i Sunyer, University of Barcelona and Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas, Spain
    J Hepatol 48:229-36. 2008
    ....
  96. ncbi request reprint Concanavalin-A-induced liver injury is severely impaired in mice deficient in P-selectin
    Anna Massaguer
    Immunology Unit, Department of Cellular Biology and Pathology, Medical School, University of Barcelona, Spain
    J Leukoc Biol 72:262-70. 2002
    ..These results implicate P-selectin in the development of Con A-induced liver injury and reveal the protective effect of blocking P-selectin in this hepatitis...
  97. ncbi request reprint Simvastatin enhances hepatic nitric oxide production and decreases the hepatic vascular tone in patients with cirrhosis
    Carmen Zafra
    Hepatic Hemodynamic Laboratory, Liver Unit, Institut de Malaties Digestives, Hospital Clinic, Institut d Investigacions Biomedique August Pi i Sunyer, University of Barcelona, Spain
    Gastroenterology 126:749-55. 2004
    ....
  98. ncbi request reprint Hemodynamic response to pharmacological treatment of portal hypertension and long-term prognosis of cirrhosis
    Juan G Abraldes
    Hepatic Hemodynamic Laboratory, Liver Unit, Institut de Malalties Digestives, Hospital Clinic, Institut de Investigacions Biomèdiques August Pi i Sunyer IDIBAPS, Universitat de Barcelona, Barcelona, Spain
    Hepatology 37:902-8. 2003
    ....
  99. doi request reprint Portal hypertension and gastrointestinal bleeding
    Jaime Bosch
    Hepatic Hemodynamic Laboratory, Liver Unit, Institut d Investigacions Biomediques August Pi i Sunyer, University of Barcelona, Spain
    Semin Liver Dis 28:3-25. 2008
    ..This article reviews the rationale for the management of portal hypertension and the current recommendations for the prevention and treatment of variceal bleeding...
  100. ncbi request reprint Effects of the V1a vasopressin agonist F-180 on portal hypertension-related bleeding in portal hypertensive rats
    Josephine Morales
    Hepatic Hemodynamic Laboratory, Liver Unit, Institut de Malalties Digestives, Hospital Clinic, Institut d Investigacions Biomediques August Pi i Sunyer, University of Barcelona, Spain
    Hepatology 38:1378-83. 2003
    ..05). In conclusion, in hypovolemic portal-hypertensive rats during a portal hypertension-related bleeding, F-180 rapidly recovers arterial pressure and decreases transfusion requirements, blood losses, and mortality...
  101. ncbi request reprint Enhanced vasoconstrictor prostanoid production by sinusoidal endothelial cells increases portal perfusion pressure in cirrhotic rat livers
    Jorge Gracia-Sancho
    Hepatic Hemodynamic Laboratory, Liver Unit, IMDiM, Hospital Clinic, Ciberehd and Institut d Investigacions Biomèdiques August Pi i Sunyer IDIBAPS, University of Barcelona, Villarroel 170, 08036 Barcelona, Spain
    J Hepatol 47:220-7. 2007
    ..Our study was aimed at investigating the role of enhanced AA bioavailability modulating the hepatic vascular tone of cirrhotic livers and identifying which prostanoid is involved...