Juan F Ascaso

Summary

Affiliation: University of Valencia
Country: Spain

Publications

  1. ncbi request reprint [Insulin resistance quantification by fasting insulin plasma values and HOMA index in a non-diabetic population]
    J F Ascaso
    Servico de Endocrinologia, Hospital Clinico Universitario de Valencia
    Med Clin (Barc) 117:530-3. 2001
  2. ncbi request reprint Effects of a controlled program of moderate physical exercise on insulin sensitivity in nonobese, nondiabetic subjects
    Berhart Hasbum
    Endocrinology and Nutrition and Respiratory Services, University Clinic Hospital, Department of Medicine, University of Valencia, Valencia, Spain
    Clin J Sport Med 16:46-50. 2006
  3. doi request reprint [Advances in cholesterol-lowering interventions]
    Juan F Ascaso
    Servicio de Endocrinologia y Nutricion, Departamento de Medicina, Hospital Clinico Universitario de Valencia, Universidad de Valencia, Valencia, Spain
    Endocrinol Nutr 57:210-9. 2010
  4. ncbi request reprint Diagnosing insulin resistance by simple quantitative methods in subjects with normal glucose metabolism
    Juan F Ascaso
    Endocrinology Service, Hospital Clinico Universitario, University of Valencia, Spain
    Diabetes Care 26:3320-5. 2003
  5. doi request reprint Prevalence of metabolic syndrome and cardiovascular disease in a hypertriglyceridemic population
    Juan F Ascaso
    Clinic University Hospital, University of Valencia, Spain
    Eur J Intern Med 22:177-81. 2011
  6. doi request reprint Evaluation of clinical diagnosis criteria of familial ligand defective apoB 100 and lipoprotein phenotype comparison between LDL receptor gene mutations affecting ligand-binding domain and the R3500Q mutation of the apoB gene in patients from a South Euro
    Ismael Ejarque
    Service of Endocrinology and Nutrition, Hospital Clinico Universitario, Department of Medicine, University of Valencia, Valencia, Spain
    Transl Res 151:162-7. 2008
  7. ncbi request reprint Influence of microsomal triglyceride transfer protein promoter polymorphism -493 GT on fasting plasma triglyceride values and interaction with treatment response to atorvastatin in subjects with heterozygous familial hypercholesterolaemia
    Ana B Garcia-Garcia
    Unidad Mixta de Investigacion, Hospital Clinico Universitario de Valencia, Spain
    Pharmacogenet Genomics 15:211-8. 2005
  8. doi request reprint Oxidative stress and antioxidant enzyme values in lymphomonocytes after an oral unsaturated fat load test in familial hypercholesterolemic subjects
    Teresa Pedro
    Service of Endocrinology and Nutrition, Hospital Clinico Universitario de Valencia, Spain
    Transl Res 161:50-6. 2013
  9. ncbi request reprint Association of C677T polymorphism in MTHFR gene, high homocysteine and low HDL cholesterol plasma values in heterozygous familial hypercholesterolemia
    Jose T Real
    Hospital Clinico Universitario, Department of Medicine, University of Valencia, Spain
    J Atheroscler Thromb 16:815-20. 2009
  10. doi request reprint Misclassification of subjects with insulin resistance and associated cardiovascular risk factors by homeostasis model assessment index. Utility of a postprandial method based on oral glucose tolerance test
    Sergio Martinez-Hervas
    Department of Medicine, Service of Endocrinology and Nutrition, Hospital Clinico Universitario, University of Valencia, E 46010 Valencia, Spain
    Metabolism 60:740-6. 2011

Collaborators

Detail Information

Publications36

  1. ncbi request reprint [Insulin resistance quantification by fasting insulin plasma values and HOMA index in a non-diabetic population]
    J F Ascaso
    Servico de Endocrinologia, Hospital Clinico Universitario de Valencia
    Med Clin (Barc) 117:530-3. 2001
    ..Our goal was to determine the prevalence of insulin resistance (IR) by means of fasting insulin plasma values and the HOMA index,and to analyse the relation of these parameters with other components of the metabolic syndrome...
  2. ncbi request reprint Effects of a controlled program of moderate physical exercise on insulin sensitivity in nonobese, nondiabetic subjects
    Berhart Hasbum
    Endocrinology and Nutrition and Respiratory Services, University Clinic Hospital, Department of Medicine, University of Valencia, Valencia, Spain
    Clin J Sport Med 16:46-50. 2006
    ..To study the effect of a moderate, aerobic physical exercise program on insulin resistance and its accompanying metabolic changes in a group of healthy, middle-age, nonobese subjects, without modifying oxygen consumption and body weight...
  3. doi request reprint [Advances in cholesterol-lowering interventions]
    Juan F Ascaso
    Servicio de Endocrinologia y Nutricion, Departamento de Medicina, Hospital Clinico Universitario de Valencia, Universidad de Valencia, Valencia, Spain
    Endocrinol Nutr 57:210-9. 2010
    ....
  4. ncbi request reprint Diagnosing insulin resistance by simple quantitative methods in subjects with normal glucose metabolism
    Juan F Ascaso
    Endocrinology Service, Hospital Clinico Universitario, University of Valencia, Spain
    Diabetes Care 26:3320-5. 2003
    ..To identify a reliable yet simple indirect method for detection of insulin resistance (IR)...
  5. doi request reprint Prevalence of metabolic syndrome and cardiovascular disease in a hypertriglyceridemic population
    Juan F Ascaso
    Clinic University Hospital, University of Valencia, Spain
    Eur J Intern Med 22:177-81. 2011
    ..We aim to study the prevalence of metabolic syndrome (MS), hypertension and diabetes, and their relationship to cardiovascular disease in subjects with hypertriglyceridemia...
  6. doi request reprint Evaluation of clinical diagnosis criteria of familial ligand defective apoB 100 and lipoprotein phenotype comparison between LDL receptor gene mutations affecting ligand-binding domain and the R3500Q mutation of the apoB gene in patients from a South Euro
    Ismael Ejarque
    Service of Endocrinology and Nutrition, Hospital Clinico Universitario, Department of Medicine, University of Valencia, Valencia, Spain
    Transl Res 151:162-7. 2008
    ..We conclude that the FDB lipoprotein phenotype was significantly less severe than that observed in FH carriers of LDLR gene missense ligand-binding domain mutations. Clinical Med-Ped diagnosis criteria tend to under-diagnose FDB...
  7. ncbi request reprint Influence of microsomal triglyceride transfer protein promoter polymorphism -493 GT on fasting plasma triglyceride values and interaction with treatment response to atorvastatin in subjects with heterozygous familial hypercholesterolaemia
    Ana B Garcia-Garcia
    Unidad Mixta de Investigacion, Hospital Clinico Universitario de Valencia, Spain
    Pharmacogenet Genomics 15:211-8. 2005
    ..In conclusion, the MTP -493 GT polymorphism modulates pre- and post-treatment plasma TG values of FH in Spanish subjects in a gender-specific way. Other environmental and genetic factors likely also modulate this response...
  8. doi request reprint Oxidative stress and antioxidant enzyme values in lymphomonocytes after an oral unsaturated fat load test in familial hypercholesterolemic subjects
    Teresa Pedro
    Service of Endocrinology and Nutrition, Hospital Clinico Universitario de Valencia, Spain
    Transl Res 161:50-6. 2013
    ..We conclude that subjects with FH exhibited OS levels that were higher than in controls before and after an OFLT, but the improvement in the OS status after the unsaturated fat load was significantly higher in subjects with FH...
  9. ncbi request reprint Association of C677T polymorphism in MTHFR gene, high homocysteine and low HDL cholesterol plasma values in heterozygous familial hypercholesterolemia
    Jose T Real
    Hospital Clinico Universitario, Department of Medicine, University of Valencia, Spain
    J Atheroscler Thromb 16:815-20. 2009
    ..to investigate the association of C677T polymorphism in the methylene tetrahydrofolate reductase (MTHFR) gene, homocysteine plasma values (Hcy), and plasma HDL cholesterol in heterozy-gous familial hypercholesterolemia (hFH)...
  10. doi request reprint Misclassification of subjects with insulin resistance and associated cardiovascular risk factors by homeostasis model assessment index. Utility of a postprandial method based on oral glucose tolerance test
    Sergio Martinez-Hervas
    Department of Medicine, Service of Endocrinology and Nutrition, Hospital Clinico Universitario, University of Valencia, E 46010 Valencia, Spain
    Metabolism 60:740-6. 2011
    ..Early identification of IR by OGTT was associated with other cardiovascular risk factors. The OGTT is a simple method that could be applied to accurately identify IR subjects in the general population...
  11. doi request reprint Classical cardiovascular risk factors according to fasting plasma glucose levels
    Sergio Martinez-Hervas
    Endocrinology Service, University Clinical Hospital, Department of Medicine University of Valencia, Spain
    Eur J Intern Med 19:209-13. 2008
    ..To compare the prevalence of classical cardiovascular risk factors (CVRF) and metabolic syndrome (MetS) in our population according to fasting plasma glucose levels (FPG)...
  12. ncbi request reprint [Determinants of postprandial lipemia measured as diurnal triglyceride profile in non diabetic normolipidemic subjects]
    Cintia González
    Hospital Clinico Universitario de Valencia, Departamento de Medicina, Universidad de Valencia, Valencia, Spain
    Med Clin (Barc) 125:448-52. 2005
    ..We decided to evaluate the clinical and biochemical predictors of postprandial lipemia, measured as daylong capillarly triglycerides (TGc) profiles, in normolipidemic non diabetic subjects...
  13. ncbi request reprint Semiquantitative multiplex PCR: a useful tool for large rearrangement screening and characterization
    Ana B Garcia-Garcia
    Fundación de Investigación Hospital Clínico Universitario de Valencia, Laboratorio de Estudios Genéticos, Hospital Clinico Universitario de Valencia, University of Valencia, Valencia, Spain
    Hum Mutat 27:822-8. 2006
    ..In addition, it constitutes a first characterization step of rearrangements, and is easy to carry out fast, and can be applied to the analysis of any gene...
  14. pmc Evaluation of a novel continuous glucose monitoring-based method for mealtime insulin dosing--the iBolus--in subjects with type 1 diabetes using continuous subcutaneous insulin infusion therapy: a randomized controlled trial
    Paolo Rossetti
    University Institute of Control Systems and Industrial Computing, Polytechnic University of Valencia, Valencia, Spain
    Diabetes Technol Ther 14:1043-52. 2012
    ..Based on continuous glucose monitoring (CGM), a method for prandial insulin administration (iBolus) is presented and evaluated for people with type 1 diabetes using CSII therapy...
  15. ncbi request reprint [Familial combined hyperlipidemia, metabolic syndrome and cardiovascular disease]
    Sergio Martinez-Hervas
    Servicio de Endocrinologia y Nutricion, Hospital Clinico Universitario, Universidad de Valencia, Valencia, Spain
    Rev Esp Cardiol 59:1195-8. 2006
    ..001); the difference between FCH patients with and without myocardial infarction was significant (P<.01). Presence of the metabolic syndrome, as defined by WHO criteria, is a marker of cardiovascular risk in individuals with FCH...
  16. ncbi request reprint [Role of atherogenic dyslipidemia in the development of metabolic syndrome]
    Jose T Real
    Servicio de Endocrinologia, Hospital Clinico Universitario, Departamento de Medicina, Universitat de Valencia, Valencia, Espana
    Med Clin (Barc) 127:321-4. 2006
    ....
  17. doi request reprint Plasma homocysteine levels are independently associated with the severity of peripheral polyneuropathy in type 2 diabetic subjects
    Ricardo Gonzalez
    Service of Endocrinology and Nutrition, Hospital Clinico Universitario de Valencia, Valencia, Spain
    J Peripher Nerv Syst 17:191-6. 2012
    ..Further prospective studies should be conducted to confirm the association of plasma Hcy levels with the grade of PN in subjects with T2DM...
  18. doi request reprint Increased oxidative stress levels and normal antioxidant enzyme activity in circulating mononuclear cells from patients of familial hypercholesterolemia
    Jose T Real
    Service of Endocrinology and Nutrition, Hospital Clinico Universitario, Department of Medicine, University of Valencia, 46010 Valencia, Spain
    Metabolism 59:293-8. 2010
    ..These data show an important alteration of OS regulation in FH and the absence of antioxidant response in CMCs mediated by some of the major antioxidant enzymes...
  19. ncbi request reprint Influence of LDL receptor gene mutations and the R3500Q mutation of the apoB gene on lipoprotein phenotype of familial hypercholesterolemic patients from a South European population
    Jose T Real
    Service of Endocrinology and Nutrition, Department of Medicine, Hospital Clinico Universitario, University of Valencia, Spain
    Eur J Hum Genet 11:959-65. 2003
    ..FDB subjects showed the lowest total and LDL cholesterol plasma values. In conclusion, the type of LDLR gene mutation and R3500Q mutation influences the lipoprotein phenotype of FH population from East Spain...
  20. ncbi request reprint [Clinical and biochemical characteristics of familial ligand-defective apo B-100 in a South European population]
    Ismael Ejarque
    Servicio de Endocrinologia y Nutricion, Hospital Clinico Universitario, Departamento de Medicina, Universidad de Valencia, Valencia, Spain
    Med Clin (Barc) 123:456-9. 2004
    ....
  21. doi request reprint Insulin resistance and oxidative stress in familial combined hyperlipidemia
    Sergio Martinez-Hervas
    Department of Medicine, Service of Endocrinology and Nutrition, Hospital Clinico Universitario de Valencia, University of Valencia, Av Blasco Ibanez 15, 46010 Valencia, Spain
    Atherosclerosis 199:384-9. 2008
    ..Correlation studies showed that 8-oxo-dG and GSSG/GSH ratio are independently related to IR with odds ratio of 3.5 and 7.4, respectively. We conclude that FCH is related to oxidative stress, especially in the presence of IR...
  22. doi request reprint Metabolic effects of regular physical exercise in healthy population
    Juan Caro
    Servicio de Endocrinologia y Nutricion, Hospital Clinico Universitario de Valencia, Valencia, Espana
    Endocrinol Nutr 60:167-72. 2013
    ..To assess the effect of moderate regular aerobic physical activity not associated to body weight changes on insulin resistance and the associated metabolic changes in general population...
  23. doi request reprint Polymorphisms of the UCP2 gene are associated with body fat distribution and risk of abdominal obesity in Spanish population
    Sergio Martinez-Hervas
    Service of Endocrinology and Nutrition, Hospital Clinico Universitario de Valencia, Department of Medicine, University of Valencia, Valencia, Spain
    Eur J Clin Invest 42:171-8. 2012
    ..Our aim was to investigate the possible association of genetic variations of the gene codifying the UCP2 protein with obesity and fat distribution...
  24. doi request reprint [Subclinical carotid atherosclerosis in patients with familial combined hyperlipidemia. Two years follow-up after treatment with high doses of atorvastatin]
    Sergio Martinez-Hervas
    Servicio de Endocrinologia y Nutricion, Hospital Clinico Universitario de Valencia, Departamento de Medicina, Universidad de Valencia, Valencia, Espana
    Med Clin (Barc) 138:1-6. 2012
    ..Our objective was to evaluate the presence of carotid alterations as a marker of systemic atherosclerosis in subjects with FCH and assess the effect of 80 mg of atorvastatin per day in carotid plaque thickness after 2 years...
  25. doi request reprint [Global therapy of diabetic dyslipidemia: benefits and new therapeutic approaches]
    Rafael Carmena
    Servicio de Endocrinologia y Nutricion, Departamento de Medicina, Hospital Clinico Universitario, Universidad de Valencia, Valencia, Espana
    Med Clin (Barc) 134:406-11. 2010
    ..In our opinion, the future treatment of diabetic dyslipidemia will include the combination of statins and other hypolipidemic agents...
  26. ncbi request reprint [Influence of plasma lipids, APOE genotype and type of LDL receptor gene mutations on myocardial infarction in subjects with familial hypercholesterolemia]
    Jose T Real
    Servicio de Endocrinologia y Nutricion, Hospital Clinico Universitario, Departamento de Medicina, Universidad de Valencia, Spain
    Med Clin (Barc) 118:681-5. 2002
    ....
  27. ncbi request reprint Significance of high density lipoprotein-cholesterol in cardiovascular risk prevention: recommendations of the HDL Forum
    Juan F Ascaso
    Endocrinology Service, Clinic University Hospital, University of Valencia, Spain
    Am J Cardiovasc Drugs 4:299-314. 2004
    ..The same therapeutic option should be considered in patients without IHD with low serum HDL-C levels and high cardiovascular risk (>20%), hypertriglyceridemia, type 2 diabetes mellitus, or metabolic syndrome...
  28. doi request reprint Circulating mononuclear cells nuclear factor-kappa B activity, plasma xanthine oxidase, and low grade inflammatory markers in adult patients with familial hypercholesterolaemia
    J T Real
    University of Valencia, Valencia, Spain
    Eur J Clin Invest 40:89-94. 2010
    ..The goal of the study was to analyse circulating mononuclear cells NF-kB and plasma XO activities in FH patients...
  29. ncbi request reprint [Hyperthyroidism in the aged]
    Jose T Real
    Servicio de Endocrinologia y Nutricion, Hospital Clinico Universitario de Valencia, Departamento de Medicina, Universitat de Valencia, Spain
    Med Clin (Barc) 118:784-7. 2002
  30. ncbi request reprint Effects of marathon running on plasma total homocysteine concentrations
    J T Real
    Endocrinología y Nutrición, Hospital Clinico Universitario de Valencia, Spain
    Nutr Metab Cardiovasc Dis 15:134-9. 2005
    ..High plasma total homocysteine (tHcy) concentrations are a recognised risk factor for CV events. Therefore, we investigated the changes in plasma tHcy concentrations 24h before and after a marathon race...
  31. doi request reprint Basal plus basal-bolus approach in type 2 diabetes
    F Javier Ampudia-Blasco
    Diabetes Reference Unit, Endocrinology and Nutrition Department, Clinic University Hospital of Valencia, Valencia, Spain
    Diabetes Technol Ther 13:S75-83. 2011
    ..This article will review the currently evidence on the basal plus strategy and also its progression to basal-bolus therapy. In addition, practical recommendations to start and adjust basal plus therapy will be provided...
  32. ncbi request reprint Association between the TaqIB polymorphism in the cholesteryl ester transfer protein gene locus and plasma lipoprotein levels in familial hypercholesterolemia
    R Carmena-Ramon
    Department of Medicine, Hospital Clinico Universitario, University of Valencia, Valencia, Spain
    Metabolism 50:651-6. 2001
    ..Moreover, the B2 allele was associated with a lower appearance of arcus cornealis, xanthomata, and clinical arteriosclerotic disease in these subjects...
  33. ncbi request reprint Impact of obesity in primary hyperlipidemias
    R Carmena
    Department of Medicine, Endocrinology Service, , University of Valencia, Valencia, Spain
    Nutr Metab Cardiovasc Dis 11:354-9. 2001
    ..Furthermore, insulin resistance is associated with a higher prevalence of coronary heart disease in this group of subjects...
  34. ncbi request reprint The influence of apo E phenotypes on the plasma triglycerides response to hormonal replacement therapy during the menopause
    M Tolosa
    Endocrinology Services, , University of Valencia, Valencia, Spain
    Maturitas 40:173-81. 2001
    ..CONCLUSION: Women with phenotype E2/E3 have higher plasma TG levels and show a significant post HRT increase compared with the other phenotypes. Other factors with a lower impact on TG levels are age and progestagen association...
  35. doi request reprint Plasma homocysteine levels are associated with ulceration of the foot in patients with type 2 diabetes mellitus
    R Gonzalez
    Service of Endocrinology and Nutrition, Hospital Clinico Universitario de Valencia, Valencia, Spain
    Diabetes Metab Res Rev 26:115-20. 2010
    ..To examine the association of biochemical markers of risk (plasma Hcy, microalbuminuria, lipoprotein (a)(Lp(a)) and diabetic dyslipidaemia) with the prevalence of diabetic foot ulceration in type 2 diabetic patients...
  36. ncbi request reprint Importance of HDL cholesterol levels and the total/ HDL cholesterol ratio as a risk factor for coronary heart disease in molecularly defined heterozygous familial hypercholesterolaemia
    J T Real
    Service of Endocrinology and Nutrition, Department of Medicine, Hospital Clinico Universitario, University of Valencia, Valencia, Spain
    Eur Heart J 22:465-71. 2001
    ..More prospective and intervention trials should be conducted to establish the relationship of HDL cholesterol levels and coronary heart disease in familial hypercholesterolaemia...