Ruben D Artero

Summary

Affiliation: University of Valencia
Country: Spain

Publications

  1. pmc Genetic and chemical modifiers of a CUG toxicity model in Drosophila
    Amparo Garcia-Lopez
    Department of Genetics, University of Valencia, Burjasot, Spain
    PLoS ONE 3:e1595. 2008
  2. pmc Drosophila muscleblind is involved in troponin T alternative splicing and apoptosis
    Marta Vicente-Crespo
    Department of Genetics, University of Valencia, Valencia, Spain
    PLoS ONE 3:e1613. 2008
  3. ncbi request reprint Two enhancers control transcription of Drosophila muscleblind in the embryonic somatic musculature and in the central nervous system
    Ariadna Bargiela
    Translational Genomics Group, Department of Genetics, University of Valencia, Valencia, Spain INCLIVA Health Research Institute, Valencia, Spain
    PLoS ONE 9:e93125. 2014
  4. pmc Muscleblind, BSF and TBPH are mislocalized in the muscle sarcomere of a Drosophila myotonic dystrophy model
    Beatriz Llamusi
    Translational Genomics Group, Department of Genetics, University of Valencia, Doctor Moliner 50, 46100 Burjasot, Valencia, Spain
    Dis Model Mech 6:184-96. 2013
  5. pmc A FRET-based assay for characterization of alternative splicing events using peptide nucleic acid fluorescence in situ hybridization
    Ana M Blanco
    Sistemas Genómicos S L, Parque Tecnológico de Valencia, Ronda G Marconi 6, E 46980 Paterna, Spain
    Nucleic Acids Res 37:e116. 2009
  6. pmc Molecular Effects of the CTG Repeats in Mutant Dystrophia Myotonica Protein Kinase Gene
    Beatriz Llamusi
    Department of Genetics, University of Valencia, Doctor Moliner, 50, E46100 Burjasot, Valencia, Spain
    Curr Genomics 9:509-16. 2008
  7. ncbi request reprint Serpent and a hibris reporter are co-expressed in migrating cells during Drosophila hematopoiesis and Malpighian tubule formation
    Ruben D Artero
    Laboratory of Developmental Genetics, Dept of Genetics, University of Valencia, Dr Moliner 50, ES 46100 Burjasot, Spain
    Hereditas 143:117-22. 2006
  8. ncbi request reprint Muscleblind isoforms are functionally distinct and regulate alpha-actinin splicing
    Marta Vicente
    Department of Genetics, University of Valencia, Doctor Moliner 50, Burjasot E 46100, Valencia, Spain
    Differentiation 75:427-40. 2007
  9. ncbi request reprint Generation of GAL4-responsive muscleblind constructs
    Ma Zaida García-Casado
    Department of Genetics, University of Valencia, Valencia, Spain
    Genesis 34:111-4. 2002
  10. pmc In vivo discovery of a peptide that prevents CUG-RNA hairpin formation and reverses RNA toxicity in myotonic dystrophy models
    Amparo Garcia-Lopez
    Department of Genetics, University of Valencia, Burjassot E 46100, Spain
    Proc Natl Acad Sci U S A 108:11866-71. 2011

Collaborators

  • Lei Zhou
  • Fabian Feiguin
  • Manuel Mata
  • Javier Terol
  • Jonathan Houseley
  • Amparo Garcia-Lopez
  • Beatriz Llamusi
  • Juan M Fernandez-Costa
  • Ariadna Bargiela
  • Manuel Perez-Alonso
  • Marta Vicente-Crespo
  • Lidon Monferrer
  • Begoña Aguado
  • Ana M Blanco
  • Marta Vicente
  • Ma Zaida García-Casado
  • Estefanía Cerro-Herreros
  • Victoria Fernandez-Pedrosa
  • Sheila Zuñiga
  • Francisco Hernández-Torres
  • Adolfo Lopez de Munain
  • Oihane Jaka
  • Jesus J Vilchez
  • Ana Aiastui
  • Raffaella Klima
  • Amelia Felipo-Benavent
  • Mar Orzáez
  • Enrique Pérez-Payá
  • Laura Rausell
  • M Carmen Alvarez-Abril
  • Maya Pascual
  • M Eugenia Miranda
  • Irma Garcia-Alcover
  • Kevin M C O'Dell
  • Darren G Monckton
  • Maurice S Swanson
  • Michael G Poulos
  • Nuria Paricio

Detail Information

Publications12

  1. pmc Genetic and chemical modifiers of a CUG toxicity model in Drosophila
    Amparo Garcia-Lopez
    Department of Genetics, University of Valencia, Burjasot, Spain
    PLoS ONE 3:e1595. 2008
    ..These findings provide new insights into the DM1 phenotype, and suggest novel candidates for DM1 treatments...
  2. pmc Drosophila muscleblind is involved in troponin T alternative splicing and apoptosis
    Marta Vicente-Crespo
    Department of Genetics, University of Valencia, Valencia, Spain
    PLoS ONE 3:e1613. 2008
    ..Such transition fails in the CTG repeat expansion disease myotonic dystrophy due, in part, to sequestration of MBNL proteins by CUG repeat RNA. Four protein isoforms (MblA-D) are coded by the unique Drosophila muscleblind gene...
  3. ncbi request reprint Two enhancers control transcription of Drosophila muscleblind in the embryonic somatic musculature and in the central nervous system
    Ariadna Bargiela
    Translational Genomics Group, Department of Genetics, University of Valencia, Valencia, Spain INCLIVA Health Research Institute, Valencia, Spain
    PLoS ONE 9:e93125. 2014
    ..The present study constitutes the first characterization of muscleblind enhancers and will contribute to a deeper understanding of the transcriptional regulation of the gene. ..
  4. pmc Muscleblind, BSF and TBPH are mislocalized in the muscle sarcomere of a Drosophila myotonic dystrophy model
    Beatriz Llamusi
    Translational Genomics Group, Department of Genetics, University of Valencia, Doctor Moliner 50, 46100 Burjasot, Valencia, Spain
    Dis Model Mech 6:184-96. 2013
    ..These results provide the first description of TBPH and BSF as targets of Mbl-mediated CTG toxicity, and they suggest an important role of these proteins in DM1 muscle pathology...
  5. pmc A FRET-based assay for characterization of alternative splicing events using peptide nucleic acid fluorescence in situ hybridization
    Ana M Blanco
    Sistemas Genómicos S L, Parque Tecnológico de Valencia, Ronda G Marconi 6, E 46980 Paterna, Spain
    Nucleic Acids Res 37:e116. 2009
    ....
  6. pmc Molecular Effects of the CTG Repeats in Mutant Dystrophia Myotonica Protein Kinase Gene
    Beatriz Llamusi
    Department of Genetics, University of Valencia, Doctor Moliner, 50, E46100 Burjasot, Valencia, Spain
    Curr Genomics 9:509-16. 2008
    ..Therapies aimed at reversing these gene expression alterations should prove effective ways to treat DM1...
  7. ncbi request reprint Serpent and a hibris reporter are co-expressed in migrating cells during Drosophila hematopoiesis and Malpighian tubule formation
    Ruben D Artero
    Laboratory of Developmental Genetics, Dept of Genetics, University of Valencia, Dr Moliner 50, ES 46100 Burjasot, Spain
    Hereditas 143:117-22. 2006
    ..We also show that hibris function is not essential for prohemocyte migration out of the procephalic mesoderm NOR maintenance of Serpent expression in prohemocytes...
  8. ncbi request reprint Muscleblind isoforms are functionally distinct and regulate alpha-actinin splicing
    Marta Vicente
    Department of Genetics, University of Valencia, Doctor Moliner 50, Burjasot E 46100, Valencia, Spain
    Differentiation 75:427-40. 2007
    ....
  9. ncbi request reprint Generation of GAL4-responsive muscleblind constructs
    Ma Zaida García-Casado
    Department of Genetics, University of Valencia, Valencia, Spain
    Genesis 34:111-4. 2002
  10. pmc In vivo discovery of a peptide that prevents CUG-RNA hairpin formation and reverses RNA toxicity in myotonic dystrophy models
    Amparo Garcia-Lopez
    Department of Genetics, University of Valencia, Burjassot E 46100, Spain
    Proc Natl Acad Sci U S A 108:11866-71. 2011
    ..In vitro, ABP1 bound to CUG hairpins and induced a switch to a single-stranded conformation. Our findings demonstrate that ABP1 shows antimyotonic dystrophy activity by targeting the core of CUG toxicity...
  11. doi request reprint Expanded CTG repeats trigger miRNA alterations in Drosophila that are conserved in myotonic dystrophy type 1 patients
    Juan M Fernandez-Costa
    Department of Genetics, University of Valencia, Burjasot 46100, Spain
    Hum Mol Genet 22:704-16. 2013
    ..Taken together, our results contribute to our understanding of the origin and the role of miRNA alterations in DM1...
  12. ncbi request reprint Noncanonical RNAs from transcripts of the Drosophila muscleblind gene
    Jonathan M Houseley
    Department of Genetics, University of Valencia, Doctor Moliner 50, 46100 Burjasot, Valencia, Spain
    J Hered 97:253-60. 2006
    ..Such noncanonical transcripts have previously been observed in vertebrates, and these data provide the first experimental evidence for similar phenomena in invertebrates...