Affiliation: University of Navarra
- Changes in subthalamic activity during movement observation in Parkinson's disease: is the mirror system mirrored in the basal ganglia?M Alegre
Neuroscience Area, CIMA, Universidad de Navarra, Pamplona, Spain
Clin Neurophysiol 121:414-25. 2010..The aim of our work was to study the changes in local field potentials (LFP) recorded from the subthalamic nucleus (STN) and their relationship with cortical activity, during movement observation...
- Oscillatory activity in the human basal ganglia: More than just beta, more than just Parkinson's diseaseManuel Alegre
Neurophysiology Laboratory, Neurosciences Area, CIMA, University of Navarra, Avenida Pio XII, 55, 31008 Pamplona, Spain Electronic address
Exp Neurol 248:183-6. 2013....
- Subthalamic activity during diphasic dyskinesias in Parkinson's diseaseManuel Alegre
Neurosciences Area, CIMA, University of Navarra, Pamplona, Spain
Mov Disord 27:1178-81. 2012..Diphasic dyskinesias are a subtype of levodopa-induced dyskinesias that appear typically at the onset and end of levodopa antiparkinsonian action. The pathophysiology of diphasic dyskinesias is not well understood...
- The mirror system, theory of mind and Parkinson's diseaseManuel Alegre
Neurophysiology Laboratory, CIMA, University of Navarra, Spain
J Neurol Sci 310:194-6. 2011..Given the relationship between the mirror system and theory of mind, we hypothesize that TOM deficits in PD might be at least partially mediated by mirror system dysfunction...
- Slow oscillatory activity and levodopa-induced dyskinesias in Parkinson's diseaseF Alonso-Frech
Department of Neurology and Neurosurgery, Neuroscience Area, Clinica Universitaria and Centro de Investigación Médica Aplicada CIMA, Universidad de Navarra Pamplona, Spain
Brain 129:1748-57. 2006..When dyskinesias were only present in one limb (n = 2), the 4-10 Hz peak was only recorded in the contralateral STN. These findings suggest that the 4-10 Hz oscillation is associated with the expression of LID in Parkinson's disease...
- Oscillatory changes related to the forced termination of a movementM Alegre
Neurophysiology Laboratory, Neuroscience Area, CIMA, Universidad de Navarra, Pamplona, Spain
Clin Neurophysiol 119:290-300. 2008..Our aim was to study the oscillatory changes related to the forced termination of a single complex motor program (signature) and compare them with those observed after the normal termination of the movement...
- Imitating versus non-imitating movements: differences in frontal electroencephalographic oscillatory activityM Alegre
Neurophysiology Section, Department of Neurology, Clinica Universitaria, Universidad de Navarra, Pio XII 36, 31008 Pamplona, Spain
Neurosci Lett 398:201-5. 2006..The beta-ERD was significantly larger in the imitation paradigm. Our results show that the motor preparation mechanisms involved in an imitated and a non-imitated movement are different...
- Gamma band responses to target and non-target auditory stimuli in humansI G Gurtubay
Neurofisiologia Clinica, Clinica Universitaria and CIMA, Universidad de Navarra, Apdo 4209, 31008 Pamplona, Spain
Neurosci Lett 367:6-9. 2004..The response around 200 ms may be involved in auditory mismatch and/or memory retrieval, and late activity is probably a P300-related response. Attention enhances all these activities...
- Chirp-evoked potentials in the awake and anesthetized rat. A procedure to assess changes in cortical oscillatory activityM Pérez-Alcázar
Neurophysiology Laboratory, Neuroscience Area, CIMA and Clinica Universitaria, Universidad de Navarra, Pamplona, Spain
Exp Neurol 210:144-53. 2008..These findings should be taken into account when assessing the changes in cortical oscillatory activity related to different drugs, in healthy rodents and in animal models of neurodegenerative diseases...
- Gamma band activity in an auditory oddball paradigm studied with the wavelet transformI G Gurtubay
Clinical Neurophysiology Unit, Department of Neurology, , Facultad de Medicina, Universidad de Navarra, Pamplona, Spain
Clin Neurophysiol 112:1219-28. 2001..002) to the latency of the P300 wave. CONCLUSIONS: EEG signal analysis with wavelet transform allows the identification of an early oscillatory cortical response in the gamma frequency range, as well as a late P300-related response...
- Movement-related changes in cortical oscillatory activity in ballistic, sustained and negative movementsM Alegre
Department of Neurology, Clinica Universitaria, Facultad de Medicina, Universidad de Navarra, Avda Pio XII 36, 31008 Pamplona Navarra, Spain
Exp Brain Res 148:17-25. 2003..Gamma band activity may be just involved in the execution of the movement, related to muscle contraction...
- Frontal and central oscillatory changes related to different aspects of the motor process: a study in go/no-go paradigmsM Alegre
Clinical Neurophysiology Section, Department of Neurology, Clinica Universitaria and Foundation for Applied Medical Research, Universidad de Navarra, 31008, Pamplona, Spain
Exp Brain Res 159:14-22. 2004....
- Cortical gamma activity during auditory tone omission provides evidence for the involvement of oscillatory activity in top-down processingI G Gurtubay
Neurophysiology Section, Clinica Universitaria, University of Navarra, Apdo 4209 31008 Pamplona, Spain
Exp Brain Res 175:463-70. 2006..In summary, our findings support the active and adaptive concept of brain function that has emerged over recent years, suggesting that the match of sensory information with memory contents generates gamma oscillations...
- Movement-related changes in oscillatory activity in the human subthalamic nucleus: ipsilateral vs. contralateral movementsM Alegre
Department of Neurology and Neurosurgery, Clinica Universitaria, Universidad de Navarra, Pamplona, Spain
Eur J Neurosci 22:2315-24. 2005..These results suggest that movement-related activity in the STN has, by and large, a bilateral representation and probably reflects cortical input...
- Alpha and beta changes in cortical oscillatory activity in a go/no go randomly-delayed-response choice reaction time paradigmM Alegre
Neurophysiology Laboratory, Neuroscience Area, Centre for Applied Medical Research, Universidad de Navarra, Pamplona, Spain
Clin Neurophysiol 117:16-25. 2006..We studied non-phase-locked changes in cortical oscillatory activity in a S1-centred double-stimulus go/no go paradigm with random interstimulus interval...
- [Video-electroencephalography: a necessity]J Iriarte
Servicio de Neurofisiologia, Departamento de Neurologia y Neurocirugia, Clinica Universidad de Navarra, Pamplona, Spain
An Sist Sanit Navar 32:83-92. 2009..In spite of the advances of recent years, 20-30% of patients diagnosed with epilepsy are not really epileptic, a fact that it is excessive and unacceptable...
- Abnormalities in brain synchronization are correlated with cognitive impairment in multiple sclerosisG Arrondo
Department of Neurosciences, CIMA University of Navarra, Pamplona, Spain
Mult Scler 15:509-16. 2009..Auditory amplitude modulation following responses (AMFR), are oscillatory steady-state responses to rhythmic auditory stimuli that indirectly measure brain synchrony...
- Topography of cortical activation differs for fundamental and harmonic frequencies of the steady-state visual-evoked responses. An EEG and PET H215O studyM A Pastor
Department of the Neurological Sciences, Center for Applied Medical Research, University of Navarra School of Medicine and the Clínica Universitaria de Navarra, Pamplona, Spain
Cereb Cortex 17:1899-905. 2007..Our finding suggests that the inferior portion of the banks of the parieto-occipital sulci contains association visual cortex involved in the processing of stimuli that can be as simple as a flickering light source...
- [The role of cortical oscillatory activity in information processing mechanisms]M Alegre
, Facultad de Medicina, Universidad de Navarra, Pamplona,
Rev Neurol 30:953-8. 2000....
- Beta electroencephalograph changes during passive movements: sensory afferences contribute to beta event-related desynchronization in humansM Alegre
Neurophysiology Section, Department of Neurology, Clinica Universitaria de Navarra, Pio XII 36, 31008, Pamplona, Spain
Neurosci Lett 331:29-32. 2002..These findings suggest that afferent proprioceptive inputs may play a role in the final part of the beta ERD observed during voluntary movements...
- Continuous positive airway pressure as treatment for catathrenia (nocturnal groaning)J Iriarte
Clinical Neurophysiology Section, Clinica Universitaria, School of Medicine, University of Navarra, Pamplona, Spain
Neurology 66:609-10. 2006
- Agrypnia excitata in fatal familial insomnia. A video-polygraphic studyJ Iriarte
Clinical Neurophysiology Section, Department of Neurology, Clinica Universitaria, University of Navarra, Pamplona, Navarra, Spain
Neurology 69:607-8. 2007
- Brainstem auditory evoked potentials (BAEPs) in the cynomolgus macaque monkey. Equivalence with human BAEPs and proposal of a new nomenclatureM Alegre
Experimental Neurophysiology Unit, Department of Neurology, , Universidade de Navarra, Pamplona, Spain
Hear Res 151:115-120. 2001..This is the reason for our proposal of a new nomenclature for BAEP waveforms in monkeys, following a descriptive order with Arabic numerals preceded by the letter M...
- [Auditory brain stem potentials evoked by electrical stimulation of cochlear nuclei during central auditive implant setting]M Alegre
, Universidad de Navarra, Pamplona,
Rev Neurol 29:198-200. 1999..More experience on this subject is needed to establish a correlation between intraoperative results and postoperative stimulator function...
- High frequency oscillations in the somatosensory evoked potentials (SSEP's) are mainly due to phase-resetting phenomenaM Valencia
Neurophysiology Laboratory, Centre for Applied Medical Research, Universidad de Navarra, Pamplona, Spain
J Neurosci Methods 154:142-8. 2006..The emergence of new activities does not seem to be a relevant mechanism in the formation of these components...
- Potentials evoked by chirp-modulated tones: a new technique to evaluate oscillatory activity in the auditory pathwayJ Artieda
Neurophysiology Section, Department of Neurology, Clínica Universitaria and Fundación para Investigación Médica Aplicada, Universidad de Navarra, Avenida Pio XII 36, 31008 Pamplona Navarra, Spain
Clin Neurophysiol 115:699-709. 2004..Our aim was to develop a fast technique to explore the oscillatory response to auditory stimuli, using a tone modulated in amplitude by a sinusoid whose frequency increases linearly in frequency ('chirp') from 1 to 120 Hz...
- [Clinical relevance of periodic limb movements during sleep in obstructive sleep apnea patients]J Iriarte
Departamento de Neurología y Neurofisiología, Universidad de Navarra, Pamplona
Rev Neurol 30:101-4. 2000..The periodic limb movements disorder (PLMD) is frequently associated with the obstructive sleep apnea syndrome (OSAS), but the prevalence and clinical relevance of this association have not been studied in detail...
- [Brain oscillations: pathophysiological and potentially therapeutic role in some neurological and psychiatric diseases]J Artieda
Servicio de Neurofisiologia Clinica, Clinica Universidad de Navarra, 31008 Pamplona, Espana
An Sist Sanit Navar 32:45-60. 2009..This review discusses all these aspects, with emphasis on their potential role both as a basic mechanism in brain function and as a pathophysiological substrate for some of the symptoms and signs observed in several diseases...
- [The pathophysiological basis of dystonia]J Artieda
Servicio de Neurofisiología Hospital Virgen del Camino, Pamplona, 31008, Espana
Rev Neurol 32:549-58. 2001..We review the mechanisms that may involved in the pathophysiology of dystonia...
- [Ictal asystolia in the differential diagnosis of dizziness]J Iriarte
Unidad de Epilepsia, Departamento de Neurologia, Clinica Universitaria de Navarra, Pamplona
Neurologia 20:45-8. 2005..Recovery was fast, but treatment with pacemaker must be considered...
- Ictal paralysis mimicking Todd's phenomenonJorge Iriarte
Epilepsy and Clinical Neurophysiology Section, Clinica Universitaria, University of Navarre, Avda Pio XII 36, Pamplona 31008, Navarre, Spain
Neurology 59:464-5. 2002
- Unilateral periodic limb movements during sleep in corticobasal degenerationJ Iriarte
Department of Neurology, Clinica Universitaria, University of Navarra, Pamplona, Navarra, Spain
Mov Disord 16:1180-3. 2001....
- [Postictal paralysis during video-EEG monitoring studies]E Urrestarazu
Unidad de Epilepsias y Servicios de Neurofisiología Clínica, Clinica Universitaria de Navarra, Universidad de Navarra, Pamplona, Espana
Rev Neurol 35:404-7. 2002..To know the frequency of Todd s paralysis during the video EEG monitoring studies, to investigate in its pathophysiology, and to confirm its value to localise the epileptic focus...
- [Lamotrigine in the adult-onset epilepsy: efficacy and long-term safety]M Alegre
Unidad de Epilepsia, Departamento de Neurología Clínica Universitaria de Navarra, Universidad de Navarra Pamplona, Spain
Neurologia 17:136-42. 2002..The mean number of AED taken per patient increased. Conclusions: LTG is a safe an effective drug in epilepsy. It has a clear impact in the management of the epileptic patients...