Neus Agell

Summary

Affiliation: University of Barcelona
Country: Spain

Publications

  1. ncbi request reprint Modulation of the Ras/Raf/MEK/ERK pathway by Ca(2+), and calmodulin
    Neus Agell
    Departament de Biologia Cel lular i Anatomia Patològica, Institut d Investigacions Biomediques August Pi i Sunyer, Facultat de Medicina Universitat de Barcelona, c Casanova, 143, 08036 Barcelona, Spain
    Cell Signal 14:649-54. 2002
  2. pmc A clathrin-dependent pathway leads to KRas signaling on late endosomes en route to lysosomes
    Albert Lu
    Departament de Biologia Cellular, Immunologia i Neurociencies, Institut d Investigacions Biomediques August Pi i Sunyer, Serveis Cientificotecnics, Facultat de Medicina, Universitat de Barcelona, Barcelona, Spain
    J Cell Biol 184:863-79. 2009
  3. pmc The stress-activated protein kinases p38α/β and JNK1/2 cooperate with Chk1 to inhibit mitotic entry upon DNA replication arrest
    Alba Llopis
    Departament de Biologia Cel lular, Immunologia i Neurociencies, Institut d Investigacions Biomediques August Pi i Sunyer, Facultat de Medicina, Universitat de Barcelona, Barcelona, Spain
    Cell Cycle 11:3627-37. 2012
  4. ncbi request reprint Different S/M checkpoint responses of tumor and non tumor cell lines to DNA replication inhibition
    Verónica Rodriguez-Bravo
    Departament de Biologia Cellular i Anatomia Patologica, Institut d Investigacions Biomediques August Pi i Sunyer, Facultat de Medicina, Universitat de Barcelona, Barcelona, Spain
    Cancer Res 67:11648-56. 2007
  5. ncbi request reprint Chk1- and claspin-dependent but ATR/ATM- and Rad17-independent DNA replication checkpoint response in HeLa cells
    Verónica Rodriguez-Bravo
    Departament de Biologia Cellular i Anatomia Patologica, Institut d Investigacions Biomediques August Pi i Sunyer, Facultat de Medicina, Universitat de Barcelona, Barcelona, Spain
    Cancer Res 66:8672-9. 2006
  6. ncbi request reprint Nucleolar disruption ensures nuclear accumulation of p21 upon DNA damage
    Neus Abella
    Departament de Biologia Cellular, Immunologia i Neurociencies, Institut d Investigacions Biomediques August Pi i Sunyer, Facultat de Medicina, Universitat de Barcelona, Spain
    Traffic 11:743-55. 2010
  7. ncbi request reprint Proteomic analysis of SET-binding proteins
    Jorge Vera
    Departament de Biologia Cel lular i Anatomia Patològica, Facultat de Medicina, Universitat de Barcelona, Barcelona, Spain
    Proteomics 7:578-87. 2007
  8. doi request reprint Identification of essential interacting elements in K-Ras/calmodulin binding and its role in K-Ras localization
    Cristina López-Alcalá
    Departament de Biologia Cellular i Anatomia Patologica, Institut d Investigacions Biomediques August Pi i Sunyer, Facultat de Medicina, Universitat de Barcelona, 08036 Barcelona, Spain
    J Biol Chem 283:10621-31. 2008
  9. ncbi request reprint P38SAPK2 phosphorylates cyclin D3 at Thr-283 and targets it for proteasomal degradation
    Oriol Casanovas
    Departament de Biologia Cel lular i Anatomia Patològica, Facultat de Medicina, Institut d Investigacions Biomediques August Pi i Sunyer, University of Barcelona, Casanova 143, 08036, Spain
    Oncogene 23:7537-44. 2004
  10. ncbi request reprint Calmodulin prevents activation of Ras by PKC in 3T3 fibroblasts
    Priam Villalonga
    Departament de Biologia Cel lular i Anatomia Patològica, Institut d Investigacions Biomediques August Pi i Sunyer IDIBAPS, Facultat de Medicina, Universitat de Barcelona, 08036 Barcelona, Spain
    J Biol Chem 277:37929-35. 2002

Collaborators

  • Priam Villalonga
  • Carlos Enrich
  • Isam Alobid
  • Laura Pujols
  • Matthias Gaestel
  • Richard Marais
  • Antonio Chiloeches
  • Franc Llorens
  • Takeshi Nakamura
  • Angel R Nebreda
  • Cesar Picado
  • Oriol Bachs
  • Montserrat Jaumot
  • Nuria Canela
  • Aina Rodriguez-Vilarrupla
  • Francesc Tebar
  • Verónica Rodriguez-Bravo
  • Blanca Alvarez-Moya
  • Maria Calvo
  • Sandra Guaita-Esteruelas
  • Cristina López-Alcalá
  • Neus Abella
  • Carles Barceló
  • Alba Llopis
  • Roger Florensa
  • Oriol Casanovas
  • Noelia Salvador
  • Albert Lu
  • Sonia Brun
  • Jorge Vera
  • Josep M Estanyol
  • Carmen Diaz
  • Vicent Esteve
  • Maribel Jaime
  • Ian Prior
  • Noelia Paco
  • Mariona Gelabert
  • Alison J Beckett
  • Eduard Garrido
  • Roger J Davis
  • Amaia Ercilla
  • Jalaj Gupta
  • Ivan del Barco Barrantes
  • Maria T Berciano
  • Miguel Lafarga
  • Olga Tapia
  • Jason D Weber
  • Michiyuki Matsuda
  • Emilio Itarte
  • Ana Belén Paules
  • Enrique Pérez-Payá
  • Rosa Aligue
  • Ismael Mingarro
  • Alexander Sorkin
  • Manuel Serrano
  • Hans Peter Rahn
  • Joan Serratosa
  • Maria Jessús Pujol
  • Tatiana Sorkina
  • Cristina Pantoja

Detail Information

Publications19

  1. ncbi request reprint Modulation of the Ras/Raf/MEK/ERK pathway by Ca(2+), and calmodulin
    Neus Agell
    Departament de Biologia Cel lular i Anatomia Patològica, Institut d Investigacions Biomediques August Pi i Sunyer, Facultat de Medicina Universitat de Barcelona, c Casanova, 143, 08036 Barcelona, Spain
    Cell Signal 14:649-54. 2002
    ..In fibroblasts, CaM binding to EGF receptor and K-Ras(B) may be involved in the downregulation of the pathway after its activation, allowing a proliferative signalling...
  2. pmc A clathrin-dependent pathway leads to KRas signaling on late endosomes en route to lysosomes
    Albert Lu
    Departament de Biologia Cellular, Immunologia i Neurociencies, Institut d Investigacions Biomediques August Pi i Sunyer, Serveis Cientificotecnics, Facultat de Medicina, Universitat de Barcelona, Barcelona, Spain
    J Cell Biol 184:863-79. 2009
    ..Altogether, this study reveals novel aspects about KRas intracellular trafficking and signaling, shedding new light on the mechanisms controlling Ras regulation in the cell...
  3. pmc The stress-activated protein kinases p38α/β and JNK1/2 cooperate with Chk1 to inhibit mitotic entry upon DNA replication arrest
    Alba Llopis
    Departament de Biologia Cel lular, Immunologia i Neurociencies, Institut d Investigacions Biomediques August Pi i Sunyer, Facultat de Medicina, Universitat de Barcelona, Barcelona, Spain
    Cell Cycle 11:3627-37. 2012
    ..Our results show a complex response to replication stress, where multiple pathways are activated and fulfill overlapping roles to prevent mitotic entry with unreplicated DNA...
  4. ncbi request reprint Different S/M checkpoint responses of tumor and non tumor cell lines to DNA replication inhibition
    Verónica Rodriguez-Bravo
    Departament de Biologia Cellular i Anatomia Patologica, Institut d Investigacions Biomediques August Pi i Sunyer, Facultat de Medicina, Universitat de Barcelona, Barcelona, Spain
    Cancer Res 67:11648-56. 2007
    ..We show that some of these responses to replication block can be lost in tumor cells, causing a defective checkpoint and providing a rationale for tumor-selective effects of combined therapies...
  5. ncbi request reprint Chk1- and claspin-dependent but ATR/ATM- and Rad17-independent DNA replication checkpoint response in HeLa cells
    Verónica Rodriguez-Bravo
    Departament de Biologia Cellular i Anatomia Patologica, Institut d Investigacions Biomediques August Pi i Sunyer, Facultat de Medicina, Universitat de Barcelona, Barcelona, Spain
    Cancer Res 66:8672-9. 2006
    ....
  6. ncbi request reprint Nucleolar disruption ensures nuclear accumulation of p21 upon DNA damage
    Neus Abella
    Departament de Biologia Cellular, Immunologia i Neurociencies, Institut d Investigacions Biomediques August Pi i Sunyer, Facultat de Medicina, Universitat de Barcelona, Spain
    Traffic 11:743-55. 2010
    ..This proved the existence of a nucleolar export route to the cytoplasm for p21(cip1) in control conditions that would be inhibited upon DNA damage leading to nuclear and nucleolar accumulation of p21(cip1)...
  7. ncbi request reprint Proteomic analysis of SET-binding proteins
    Jorge Vera
    Departament de Biologia Cel lular i Anatomia Patològica, Facultat de Medicina, Universitat de Barcelona, Barcelona, Spain
    Proteomics 7:578-87. 2007
    ..These data confirm this proteomic approach as a useful tool for identifying new protein-protein interactions...
  8. doi request reprint Identification of essential interacting elements in K-Ras/calmodulin binding and its role in K-Ras localization
    Cristina López-Alcalá
    Departament de Biologia Cellular i Anatomia Patologica, Institut d Investigacions Biomediques August Pi i Sunyer, Facultat de Medicina, Universitat de Barcelona, 08036 Barcelona, Spain
    J Biol Chem 283:10621-31. 2008
    ....
  9. ncbi request reprint P38SAPK2 phosphorylates cyclin D3 at Thr-283 and targets it for proteasomal degradation
    Oriol Casanovas
    Departament de Biologia Cel lular i Anatomia Patològica, Facultat de Medicina, Institut d Investigacions Biomediques August Pi i Sunyer, University of Barcelona, Casanova 143, 08036, Spain
    Oncogene 23:7537-44. 2004
    ..Alterations of this mechanism might be important for oncogenesis...
  10. ncbi request reprint Calmodulin prevents activation of Ras by PKC in 3T3 fibroblasts
    Priam Villalonga
    Departament de Biologia Cel lular i Anatomia Patològica, Institut d Investigacions Biomediques August Pi i Sunyer IDIBAPS, Facultat de Medicina, Universitat de Barcelona, 08036 Barcelona, Spain
    J Biol Chem 277:37929-35. 2002
    ....
  11. doi request reprint Oncogenic K-ras segregates at spatially distinct plasma membrane signaling platforms according to its phosphorylation status
    Carles Barceló
    Departament de Biologia Cel lular, Immunologia i Neurociencies, Institut d Investigacions Biomediques August Pi i Sunyer IDIBAPS, Facultat de Medicina Universitat de Barcelona, C Casanova 143, 08036 Barcelona, Spain
    J Cell Sci 126:4553-9. 2013
    ....
  12. ncbi request reprint Identification of the nuclear localization signal of p21(cip1) and consequences of its mutation on cell proliferation
    Aina Rodriguez-Vilarrupla
    Departament de Biologia Cellular i Anatomia Patologica, Institut d Investigacions Biomediques August Pi i Sunyer IDIBAPS, Facultat de Medicina, Universitat de Barcelona, c Casanova, Barcelona, Spain
    FEBS Lett 531:319-23. 2002
    ..We conclude that cytoplasmatic p21, with no deletion in the C-terminal region, had a much lower capacity to arrest the cell cycle...
  13. doi request reprint Proteasome inhibition reduces proliferation, collagen expression, and inflammatory cytokine production in nasal mucosa and polyp fibroblasts
    Laura Pujols
    Clinical and Experimental Respiratory Immunoallergy, Institut d Investigacions Biomediques August Pi i Sunyer, and Centro de Investigaciones Respiratorias en Red de Enfermedades Respiratorias, Barcelona, Spain
    J Pharmacol Exp Ther 343:184-97. 2012
    ..We conclude that noncytotoxic treatment with MG262 reduces the proliferative, fibrotic, and inflammatory response of nasal fibroblasts, whereas high MG262 concentrations induce apoptosis...
  14. ncbi request reprint ATM/ATR-independent inhibition of cyclin B accumulation in response to hydroxyurea in nontransformed cell lines is altered in tumour cell lines
    Roger Florensa
    Departament de Biologia Cel lular i Anatomia Patològica, Institut d Investigacions Biomediques August Pi i Sunyer, Facultat de Medicina, Universitat de Barcelona, 08036 Barcelona, Spain
    Oncogene 22:8283-92. 2003
    ..Lack of cyclin B1 accumulation after DNA synthesis inhibition in NRK cells was not due to increased degradation of the protein, but correlated with a decrease in mRNA accumulation...
  15. pmc Calmodulin regulates intracellular trafficking of epidermal growth factor receptor and the MAPK signaling pathway
    Francesc Tebar
    Departament de Biologia Cel lular, Facultat de Medicina, Institut d Investigacions August Pi i Sunyer IDIBAPS, Universitat de Barcelona, Barcelona, Spain 08036
    Mol Biol Cell 13:2057-68. 2002
    ..These data are consistent with the regulation of EGFR by calmodulin at several steps of the receptor signaling and trafficking pathways...
  16. ncbi request reprint The diverging roles of calmodulin and PKC in the regulation of p21 intracellular localization
    Neus Agell
    Departament de Biologia Cellular i Anatomia Patologica, Institut d Investigacions Biomediques August Pi i Sunyer IDIBAPS, Facultat de Medicina, Universitat de Barcelona, Barcelona, Spain
    Cell Cycle 5:3-6. 2006
    ..We discuss here the effects of such phosphorylations on p21 functionality, as well as its relevance to cell cycle progression and differentiation...
  17. pmc Binding of calmodulin to the carboxy-terminal region of p21 induces nuclear accumulation via inhibition of protein kinase C-mediated phosphorylation of Ser153
    Aina Rodriguez-Vilarrupla
    Department de Biologia Cel lular, Fac Medicina, Barcelona, Spain
    Mol Cell Biol 25:7364-74. 2005
    ..We propose that calmodulin binding to p21 prevents its phosphorylation by PKC at Ser153 and consequently allows its nuclear localization. When phosphorylated at Ser153, p21 is located at the cytoplasm and disrupts stress fibers...
  18. ncbi request reprint The structural plasticity of the C terminus of p21Cip1 is a determinant for target protein recognition
    Vicent Esteve
    Dept Bioquimica i Biologia Molecular, Universitat de Valencia, 46100 Burjassot, Valencia, Spain
    Chembiochem 4:863-9. 2003
    ..Our results suggest that the C-terminal domain of p21(Cip1) adopts an extended structure when bound to PCNA and probably when bound to the oncoprotein SET, but an alpha helix when bound to CaM...
  19. ncbi request reprint The p21(Cip1) protein, a cyclin inhibitor, regulates the levels and the intracellular localization of CDC25A in mice regenerating livers
    Maribel Jaime
    Department of Cell Biology and Pathology, Faculty of Medicine, Institut d Investigacions Biomédiques August Pi Sunyer IDIBAPS, University of Barcelona, Barcelona, Spain
    Hepatology 35:1063-71. 2002
    ..In conclusion, premature translocation of CDC25A to the nucleus might be involved in the advanced induction of cyclin E/CDK2 activity and DNA replication in cells from animals lacking p21(Cip1)...