Research Topics

Genomes and Genes


Merce Pallas


Affiliation: Universitat de Barcelona
Country: Spain


  1. Griñan Ferré C, Vasilopoulou F, Abás S, Rodríguez Arévalo S, Bagán A, Sureda F, et al. Behavioral and Cognitive Improvement Induced by Novel Imidazoline I2 Receptor Ligands in Female SAMP8 Mice. Neurotherapeutics. 2018;: pubmed publisher
  2. request reprint
    Pallas M, Porquet D, Vicente A, Sanfeliu C. Resveratrol: new avenues for a natural compound in neuroprotection. Curr Pharm Des. 2013;19:6726-31 pubmed
    ..While not all reported results are free from controversy, the demographic shift toward an older population makes compounds with this broad spectrum of potential clinical applications particularly interesting. ..
  3. Griñan Ferré C, Pérez Cáceres D, Gutiérrez Zetina S, Camins A, Palomera Avalos V, Ortuño Sahagún D, et al. Environmental Enrichment Improves Behavior, Cognition, and Brain Functional Markers in Young Senescence-Accelerated Prone Mice (SAMP8). Mol Neurobiol. 2016;53:2435-50 pubmed publisher
  4. Puigoriol Illamola D, Griñan Ferré C, Vasilopoulou F, Leiva R, Vazquez S, Pallas M. 11β-HSD1 Inhibition by RL-118 Promotes Autophagy and Correlates with Reduced Oxidative Stress and Inflammation, Enhancing Cognitive Performance in SAMP8 Mouse Model. Mol Neurobiol. 2018;55:8904-8915 pubmed publisher
    ..We concluded that inhibition of 11β-HSD1 by RL-118 prevented neurodegenerative processes and cognitive decline, acting on autophagy process, being an additional neuroprotective mechanism not described previously. ..
  5. Palomera Ávalos V, Griñán Ferré C, Puigoriol Ilamola D, Camins A, Sanfeliu C, Canudas A, et al. Resveratrol Protects SAMP8 Brain Under Metabolic Stress: Focus on Mitochondrial Function and Wnt Pathway. Mol Neurobiol. 2017;54:1661-1676 pubmed publisher
  6. Pallas M, Pizarro J, Gutierrez Cuesta J, Crespo Biel N, Alvira D, Tajes M, et al. Modulation of SIRT1 expression in different neurodegenerative models and human pathologies. Neuroscience. 2008;154:1388-97 pubmed publisher
    ..SIRT1 expression decreased dramatically in HD, but there were no significant changes in Parkinson-related illnesses. In conclusion, SIRT1 expression may be a good sensor of toxic neuronal processes. ..
  7. Griñan Ferré C, Palomera Ávalos V, Puigoriol Illamola D, Camins A, Porquet D, Plá V, et al. Behaviour and cognitive changes correlated with hippocampal neuroinflammaging and neuronal markers in female SAMP8, a model of accelerated senescence. Exp Gerontol. 2016;80:57-69 pubmed publisher
    ..These changes are reflected in the emotional and cognitive behaviour of SAMP8 that differs from that of SAMR1 and that highlighted the importance of earlier oxidative processes in the onset of neurodegeneration. ..
  8. Palomera Ávalos V, Griñán Ferré C, Izquierdo V, Camins A, Sanfeliu C, Canudas A, et al. Resveratrol modulates response against acute inflammatory stimuli in aged mouse brain. Exp Gerontol. 2018;102:3-11 pubmed publisher
    ..In conclusion, resveratrol treatment induced a different cellular response in aged animals when they encountered acute inflammatory stimuli. ..