Merce Pallas

Summary

Affiliation: Universitat de Barcelona
Country: Spain

Publications

  1. pmc Lack of synergistic effect of resveratrol and sigma-1 receptor agonist (PRE-084) in SOD1G⁹³A ALS mice: overlapping effects or limited therapeutic opportunity?
    Renzo Mancuso
    Institute of Neurosciences and Department of Cell Biology, Physiology and Immunology, Universitat Autonoma de Barcelona, and Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas CIBERNED, Bellaterra, Spain
    Orphanet J Rare Dis 9:78. 2014
  2. pmc Rcor2 underexpression in senescent mice: a target for inflammaging?
    María J Alvarez-López
    Instituto de Investigaciones Biomédicas August Pi i Sunyer IDIBAPS, Rosellón 149, E 08036 Barcelona, Spain
    J Neuroinflammation 11:126. 2014
  3. ncbi request reprint Resveratrol: new avenues for a natural compound in neuroprotection
    Merce Pallas
    Unitat de Farmacologia i Farmacognòsia Facultat de Farmàcia, Institut de Biomedicina IBUB, Centros de Investigación Biomédica en Red de Enfermedades Neurodegenerativas CIBERNED Universitat de Barcelona Nucli Universitari de
    Curr Pharm Des 19:6726-31. 2013
  4. ncbi request reprint Flavopiridol: an antitumor drug with potential application in the treatment of neurodegenerative diseases
    M Pallas
    Unitat de Farmacologia i Farmacognosia, Facultat de Farmacia, Universitat de Barcelona, Nucli Universitari de Pedralbes, E 08028 Barcelona, Spain
    Med Hypotheses 64:120-3. 2005
  5. doi request reprint Long-term treadmill exercise induces neuroprotective molecular changes in rat brain
    S Bayod
    Unitat de Farmacologia i Farmacognòsia Facultat de Farmàcia, Universitat de Barcelona, Nucli Universitari de Pedralbes, E 08028 Barcelona, Spain
    J Appl Physiol (1985) 111:1380-90. 2011
  6. ncbi request reprint Molecular and biochemical features in Alzheimer's disease
    Merce Pallas
    Unitat de Farmacologia i Farmacognosia, Facultat de Farmacia, Universitat de Barcelona, Nucli Universitari de Pedralbes, E 08028 Barcelona, Spain
    Curr Pharm Des 12:4389-408. 2006
  7. ncbi request reprint Modulation of sirtuins: new targets for antiageing
    Merce Pallas
    Unitat de Farmacologia i Farmacognòsia i Institut de Biomedicina IBUB, Facultat de Farmacia, Universitat de Barcelona, Nucli Universitari de Pedralbes, E 08028 Barcelona, Spain
    Recent Pat CNS Drug Discov 3:61-9. 2008
  8. doi request reprint Modulation of SIRT1 expression in different neurodegenerative models and human pathologies
    M Pallas
    Unitat de Farmacologia i Farmacognosia, Facultat de Farmacia i Institut de Biomedicina IBUB, Universitat de Barcelona, Nucli Universitari de Pedralbes, Barcelona, Spain
    Neuroscience 154:1388-97. 2008
  9. ncbi request reprint Neuroprotective action of flavopiridol, a cyclin-dependent kinase inhibitor, in colchicine-induced apoptosis
    Elvira G Jorda
    Unitat de Farmacologia i Farmacognosia, Facultat de Farmacia, Universitat de Barcelona, Nucli Universitari de Pedralbes, 08028 Barcelona, Spain
    Neuropharmacology 45:672-83. 2003
  10. ncbi request reprint Neuroprotective effects of (+/-)-huprine Y on in vitro and in vivo models of excitoxicity damage
    Anna M Canudas
    Unitat de Farmacologia i Farmacognosia, Facultat de Farmacia, Universitat de Barcelona, Barcelona, Spain
    Exp Neurol 180:123-30. 2003

Collaborators

Detail Information

Publications91

  1. pmc Lack of synergistic effect of resveratrol and sigma-1 receptor agonist (PRE-084) in SOD1G⁹³A ALS mice: overlapping effects or limited therapeutic opportunity?
    Renzo Mancuso
    Institute of Neurosciences and Department of Cell Biology, Physiology and Immunology, Universitat Autonoma de Barcelona, and Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas CIBERNED, Bellaterra, Spain
    Orphanet J Rare Dis 9:78. 2014
    ..The main goal of this work was to assess the effect of combined RSV and PRE-084 administration in SOD1G93A ALS mice...
  2. pmc Rcor2 underexpression in senescent mice: a target for inflammaging?
    María J Alvarez-López
    Instituto de Investigaciones Biomédicas August Pi i Sunyer IDIBAPS, Rosellón 149, E 08036 Barcelona, Spain
    J Neuroinflammation 11:126. 2014
    ..In this context, recent studies have described the role of chromatin regulators in inflammation and longevity including the REST corepressor (Rcor)-2 factor, which seems to be involved in an inflammatory suppressive program...
  3. ncbi request reprint Resveratrol: new avenues for a natural compound in neuroprotection
    Merce Pallas
    Unitat de Farmacologia i Farmacognòsia Facultat de Farmàcia, Institut de Biomedicina IBUB, Centros de Investigación Biomédica en Red de Enfermedades Neurodegenerativas CIBERNED Universitat de Barcelona Nucli Universitari de
    Curr Pharm Des 19:6726-31. 2013
    ..While not all reported results are free from controversy, the demographic shift toward an older population makes compounds with this broad spectrum of potential clinical applications particularly interesting. ..
  4. ncbi request reprint Flavopiridol: an antitumor drug with potential application in the treatment of neurodegenerative diseases
    M Pallas
    Unitat de Farmacologia i Farmacognosia, Facultat de Farmacia, Universitat de Barcelona, Nucli Universitari de Pedralbes, E 08028 Barcelona, Spain
    Med Hypotheses 64:120-3. 2005
    ..Expression of CDKs was observed in rodent models of excitotoxicity and stroke, and CDK inhibitors showed neuroprotective effects. Flavopiridol may provide significant improvement in neurodegenerative diseases in humans...
  5. doi request reprint Long-term treadmill exercise induces neuroprotective molecular changes in rat brain
    S Bayod
    Unitat de Farmacologia i Farmacognòsia Facultat de Farmàcia, Universitat de Barcelona, Nucli Universitari de Pedralbes, E 08028 Barcelona, Spain
    J Appl Physiol (1985) 111:1380-90. 2011
    ..These findings are consistent with other reports showing that physical exercise has positive effects on hormesis...
  6. ncbi request reprint Molecular and biochemical features in Alzheimer's disease
    Merce Pallas
    Unitat de Farmacologia i Farmacognosia, Facultat de Farmacia, Universitat de Barcelona, Nucli Universitari de Pedralbes, E 08028 Barcelona, Spain
    Curr Pharm Des 12:4389-408. 2006
    ..Finally, a multiple therapy with antioxidants, cell cycle inhibitors and other drugs modulating APP processing could be, in the future, a suitable strategy in order to delay Alzheimer's disease progression...
  7. ncbi request reprint Modulation of sirtuins: new targets for antiageing
    Merce Pallas
    Unitat de Farmacologia i Farmacognòsia i Institut de Biomedicina IBUB, Facultat de Farmacia, Universitat de Barcelona, Nucli Universitari de Pedralbes, E 08028 Barcelona, Spain
    Recent Pat CNS Drug Discov 3:61-9. 2008
    ....
  8. doi request reprint Modulation of SIRT1 expression in different neurodegenerative models and human pathologies
    M Pallas
    Unitat de Farmacologia i Farmacognosia, Facultat de Farmacia i Institut de Biomedicina IBUB, Universitat de Barcelona, Nucli Universitari de Pedralbes, Barcelona, Spain
    Neuroscience 154:1388-97. 2008
    ..SIRT1 expression decreased dramatically in HD, but there were no significant changes in Parkinson-related illnesses. In conclusion, SIRT1 expression may be a good sensor of toxic neuronal processes...
  9. ncbi request reprint Neuroprotective action of flavopiridol, a cyclin-dependent kinase inhibitor, in colchicine-induced apoptosis
    Elvira G Jorda
    Unitat de Farmacologia i Farmacognosia, Facultat de Farmacia, Universitat de Barcelona, Nucli Universitari de Pedralbes, 08028 Barcelona, Spain
    Neuropharmacology 45:672-83. 2003
    ..Our data suggest a potential therapeutic use of flavopiridol in disorders of the central nervous system in which cytoskeleton alteration mediated by cdk5 activation and Par-4 expression has been demonstrated, such as Alzheimer's disease...
  10. ncbi request reprint Neuroprotective effects of (+/-)-huprine Y on in vitro and in vivo models of excitoxicity damage
    Anna M Canudas
    Unitat de Farmacologia i Farmacognosia, Facultat de Farmacia, Universitat de Barcelona, Barcelona, Spain
    Exp Neurol 180:123-30. 2003
    ..In conclusion, (+/-)-huprine Y attenuated excitotoxic-induced lesions, both in vitro and in vivo, and further evidence is provided for the potential use of this compound in the prevention of neurodegenerative disorders...
  11. ncbi request reprint Neurotoxicity of amphetamine derivatives is mediated by caspase pathway activation in rat cerebellar granule cells
    Andrés Jiménez
    Unitat de Farmacologia i Farmacognosia, Facultat de Farmacia, Universitat de Barcelona, Barcelona 08028, Spain
    Toxicol Appl Pharmacol 196:223-34. 2004
    ..There was also indication of caspase-3-like activation, measured by immunoanalysis and biochemically. Finally, neurodegenerative action caused by amphetamine derivatives may be prevented by using caspase inhibitors...
  12. doi request reprint Activation of ataxia telangiectasia muted under experimental models and human Parkinson's disease
    Antoni Camins
    Institut de Biomedicina, Centros de Investigación Biomédica en Red de Enfermedades Neurodegenerativas, Universitat de Barcelona, Spain
    Cell Mol Life Sci 67:3865-82. 2010
    ..Therefore, this study demonstrates a new link between DNA damage by MPP(+) and cell-cycle re-entry through retinoblastoma protein phosphorylation...
  13. doi request reprint Cell cycle activation in striatal neurons from Huntington's disease patients and rats treated with 3-nitropropionic acid
    Carme Pelegri
    Departament de Fisiologia, Facultat de Farmacia, Universitat de Barcelona, Av Joan XXIII s n, 08028 Barcelona, Spain
    Int J Dev Neurosci 26:665-71. 2008
    ..These results indicate that cell cycle re-entry is activated in Huntington's disease and may contribute to the neurodegenerative process...
  14. doi request reprint GSK3β inhibition is involved in the neuroprotective effects of cyclin-dependent kinase inhibitors in neurons
    Aurelio Vazquez de la Torre
    Unitat de Farmacologia i Farmacognosia, Facultat de Farmacia, Centros de Investigación Biomédica en Red Enfermedades Neurodegenerativas CIBERNED, Institut de Biomedicina IBUB, Universitat de Barcelona, Nucli Universitari de Pedralbes, 08028 Barcelona, Spain
    Pharmacol Res 65:66-73. 2012
    ..Therefore, our data identify GSK3β as a crucial mediator of CGN apoptosis induced by PI3K inhibition and indicate that the antiapoptotic effects of CDKs are mediated by the inhibition of this pharmacological target...
  15. ncbi request reprint Inhibition of multiple pathways accounts for the antiapoptotic effects of flavopiridol on potassium withdrawal-induced apoptosis in neurons
    Ester Verdaguer
    Unitat de Farmacologia i Farmacognosia, Facultat de Farmacia, Universitat de Barcelona, Nucli Universitari de Pedralbes, E 08028 Barcelona, Spain
    J Mol Neurosci 26:71-84. 2005
    ..We propose that the antiapoptotic properties of flavopiridol are mediated through kinase pathway inhibition...
  16. ncbi request reprint Evaluation of neuronal cell death by laser scanning cytometry
    Ester Verdaguer
    Unitat de Farmacologia i Farmacognosia, Facultat de Farmacia, Universitat de Barcelona, Nucli Universitari de Pedralbes, E 08028, Barcelona, Spain
    Brain Res Brain Res Protoc 9:41-8. 2002
    ..The protocol presented here, provides a fast and sensitive assay for the analysis of neuronal viability using LSC, and can be used to study new neuroprotective drugs in neuronal cell cultures...
  17. doi request reprint Systemic administration of 3-nitropropionic acid points out a different role for active caspase-3 in neurons and astrocytes
    Joaquim Duran-Vilaregut
    Departament de Fisiologia, Facultat de Farmacia, Universitat de Barcelona, Av Joan XXIII s n, 08028 Barcelona, Spain
    Neurochem Int 56:443-50. 2010
    ..This indicates the presence of a caspase-mediated apoptotic process. TUNEL was not present in control animals or in the astrocytes of treated animals. Thus, the presence of active caspase-3 in astrocytes may be merely constitutive...
  18. doi request reprint Oxidative stress-induced DNA damage and cell cycle regulation in B65 dopaminergic cell line
    Javier G Pizarro
    Unitat de Farmacologia i Farmacognosia, Institut de Biomedicina, Centro de Investigacion Biomedica en Red de Enfermedades Neurodegenerativas, Facultat de Farmacia, Universitat de Barcelona, Nucli Universitari de Pedralbes, Barcelona, Spain
    Free Radic Res 43:985-94. 2009
    ..In summary, this study describes the molecular mechanisms involved in cell cycle alterations induced by oxidative stress in B65 cells. These findings highlight the relevance of ATM in the regulation of cell cycle after oxidative stress...
  19. pmc Cyclosporin A enhances colchicine-induced apoptosis in rat cerebellar granule neurons
    Anna Maria Canudas
    Unitat de Farmacologia i Farmacognosia, Facultat de Farmacia, Universitat de Barcelona, Nucli Universitari de Pedralbes, Barcelona E 08028, Spain
    Br J Pharmacol 141:661-9. 2004
    ..5. Immunohistochemical results showed a nuclear localization of cdk5 after neurotoxic treatment, which was prevented by cdk inhibitors. Thus, we propose a new mechanism of modulation of CsA neurotoxicity mediated by cdk5...
  20. doi request reprint Lithium treatment decreases activities of tau kinases in a murine model of senescence
    Marta Tajes
    Unitat de Farmacologia, Facultat de Farmácia Institut de Biomedicina Universitat de Barcelona, Nucli Universitari de Pedralbes, Barcelona, Spain
    J Neuropathol Exp Neurol 67:612-23. 2008
    ....
  21. doi request reprint Neuroprotective effects of SB-415286 on hydrogen peroxide-induced cell death in B65 rat neuroblastoma cells and neurons
    Javier G Pizarro
    Unitat de Farmacologia i Farmacognòsia i Institut de Biomedicina IBUB, Facultat de Farmacia, Universitat de Barcelona, Nucli Universitari de Pedralbes, Barcelona, Spain
    Int J Dev Neurosci 26:269-76. 2008
    ..We conclude that the GSK-3 inhibitor SB-415286 has antioxidant properties, which may explain the cytoprotective effects against H(2)O(2) damage. Furthermore, inhibition of GSK-3 activity was not involved in this protective effect...
  22. doi request reprint Expression pattern of ataxia telangiectasia mutated (ATM), p53, Akt, and glycogen synthase kinase-3β in the striatum of rats treated with 3-nitropropionic acid
    Joaquim Duran-Vilaregut
    Departament de Fisiologia, Facultat de Farmacia, Universitat de Barcelona, Barcelona, Spain
    J Neurosci Res 90:1803-13. 2012
    ..The inactive form of GSK3β was detected extensively, mainly in the rim of the striatal lesions around degenerating neurons, which could be attributed to a cell death or cell survival response...
  23. doi request reprint ATM is involved in cell-cycle control through the regulation of retinoblastoma protein phosphorylation
    Javier G Pizarro
    Unitat de Farmacologia i Farmacognosia, Institut de Biomedicina IBUB, Centro deInvestigacion Biomedica en Red de Enfermedades Neurodegenerativas CIBERNED, Facultat de Farmacia, Universitat de Barcelona, Nucli Universitari de Pedralbes, Barcelona E 08028, Spain
    J Cell Biochem 110:210-8. 2010
    ..Collectively, our data demonstrate how a new molecular network on ATM regulates the cell cycle through the control of pRb phosphorylation. These findings support a new target of ATM...
  24. doi request reprint Effects of MPP+ on the molecular pathways involved in cell cycle control in B65 neuroblastoma cells
    Javier G Pizarro
    Unitat de Farmacologia i Farmacognosia, Institut de Biomedicina IBUB, Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas CIBERNED, Universitat de Barcelona, Nucli Universitari de Pedralbes, 08028 Barcelona, Spain
    Pharmacol Res 61:391-9. 2010
    ..In summary, the present work characterizes the molecular changes involved in damage caused by MPP(+) in B65 cells, and highlights the effects of MPP(+) on molecules involved in the control of cell cycle progression...
  25. doi request reprint Antiapoptotic effects of roscovitine on camptothecin-induced DNA damage in neuroblastoma cells
    Javier G Pizarro
    Centros de Investigación Biomédica en Red Enfermedades Neurodegenerativas, Unitat de Farmacologia i Farmacognosia, Facultat de Farmacia, Institut de Biomedicina, Universitat de Barcelona, Nucli Universitari de Pedralbes, Spain
    Apoptosis 16:536-50. 2011
    ..Our findings have a potential clinical implication, suggesting that combinatory drugs in the treatment of cancer activation should be administered with caution...
  26. pmc Dietary resveratrol prevents Alzheimer's markers and increases life span in SAMP8
    David Porquet
    Unitat de Farmacologia i Farmacognosia, Facultat de Farmacia, Institut de Biomedicina IBUB, Centros de Investigación Biomédica en Red de Enfermedades Neurodegenerativas CIBERNED, Av Joan XXIII s n, 08028, Barcelona, Spain
    Age (Dordr) 35:1851-65. 2013
    ..It also reduces cognitive impairment and has a neuroprotective role, decreasing the amyloid burden and reducing tau hyperphosphorylation. ..
  27. pmc Kainic acid-induced neuronal cell death in cerebellar granule cells is not prevented by caspase inhibitors
    Ester Verdaguer
    Unitat de Farmacologia i Farmacognosia, Facultat de Farmacia, Universitat de Barcelona, Nucli Universitari de Pedralbes, E 08028 Barcelona, Spain
    Br J Pharmacol 135:1297-307. 2002
    ..5. The calpain inhibitor ALLN had no effect on KA or colchicine-induced neurotoxicity. 6. Our findings indicate that colchicine-induced apoptosis in CGCs is mediated by caspase-3 activation, unlike KA-induced apoptosis...
  28. ncbi request reprint Antiapoptotic effects of roscovitine in cerebellar granule cells deprived of serum and potassium: a cell cycle-related mechanism
    Ester Verdaguer
    Unitat de Farmacologia i Farmacognosia, Facultat de Farmacia, Universitat de Barcelona, Nucli Universitari de Pedralbes, E 08028 Barcelona, Spain
    Neurochem Int 44:251-61. 2004
    ..We suggest that the antiapoptotic effects of roscovitine on CGNs are due to its anti-proliferative efficacy and to an action on the mitochondrial apoptotic mechanism...
  29. ncbi request reprint Inhibition of the cdk5/p25 fragment formation may explain the antiapoptotic effects of melatonin in an experimental model of Parkinson's disease
    Daniel Alvira
    Unitat de Farmacologia i Farmacognosia, Facultat de Farmacia, Universitat de Barcelona, Nucli Universitari de Pedralbes, Barcelona, Spain
    J Pineal Res 40:251-8. 2006
    ..Moreover, these data suggest that the calpain/cdk5 signaling cascade has a potential role in the MPP+ -mediated apoptotic process in CGNs...
  30. doi request reprint Differences in activation of ERK1/2 and p38 kinase in Jnk3 null mice following KA treatment
    Luisa de Lemos
    Unitat de Farmacologia i Farmacognòsia Facultat de Farmàcia, Institut de Biomedicina IBUB, Centros de Investigación Biomédica en Red de Enfermedades Neurodegenerativas CIBERNED, Universitat de Barcelona, Barcelona, Spain
    J Neurochem 114:1315-22. 2010
    ..Therefore, the data indicate that the lack of the JNK3 protein modulates other MAPKs and these changes could also have a pivotal role in neuroprotection...
  31. ncbi request reprint Different glial response to methamphetamine- and methylenedioxymethamphetamine-induced neurotoxicity
    David Pubill
    Unitat de Farmacologia i Farmacognosia, Facultat de Farmacia, Universitat de Barcelona, Nucli Universitari de Pedralbes, 08028 Barcelona, Spain
    Naunyn Schmiedebergs Arch Pharmacol 367:490-9. 2003
    ..The differences in glial activation between methamphetamine and MDMA observed in the present study could have implications for the prognosis of the injury induced by these drugs...
  32. doi request reprint PI3 k/akt inhibition induces apoptosis through p38 activation in neurons
    Aurelio Vazquez De la Torre
    Unitat de Farmacologia i Farmacognòsia Facultat de Farmàcia, Centros de Investigación Biomédica en Red Enfermedades Neurodegenerativas CIBERNED, Institut de Biomedicina IBUB, Universitat de Barcelona, Nucli Universitari de Pedralbes, 08028 Barcelona, Spain
    Pharmacol Res 70:116-25. 2013
    ..Taken together, our data demonstrate that PI3K/AKT inhibition induces neuronal apoptosis, a process that is mediated by the activation of p38 MAPK/c-Jun/dp5...
  33. pmc A molecular study of pathways involved in the inhibition of cell proliferation in neuroblastoma B65 cells by the GSK-3 inhibitors lithium and SB-415286
    Javier G Pizarro
    Unitat de Farmacologia i Farmacognosia, Facultat de Farmacia, Institut de Biomedicina and Centros de Investigación Biomédica en Red de Enfermedades Neurodegenerativas, Universitat de Barcelona, Nucli Universitari de Pedralbes, Barcelona, Spain
    J Cell Mol Med 13:3906-17. 2009
    ..We conclude that inhibitors of GSK-3 induced cell-cycle arrest, mediated by the phosphorylation of cdc2 and, in the case of SB-415286, SIRT2 expression, which induced apoptosis in a caspase-independent manner...
  34. doi request reprint Kainate-induced toxicity in the hippocampus: potential role of lithium
    Natalia Crespo-Biel
    Unitat de Farmacologia i Farmacognòsia i Institut de Biomedicina IBUB i Centro de Investigación de Biomedicina en Red de Enfermedades Neurodegenerativas CIBERNED, Facultat de Farmacia, Universitat de Barcelona, Nucli Universitari de Pedralbes, Barcelona, Spain
    Bipolar Disord 12:425-36. 2010
    ..We investigated the neuroprotective effects of lithium in an experimental neurodegeneration model gated to kainate (KA) receptor activation...
  35. doi request reprint Time-course of blood-brain barrier disruption in senescence-accelerated mouse prone 8 (SAMP8) mice
    Jaume del Valle
    Departament de Fisiologia, Facultat de Farmacia, Universitat de Barcelona, Av Joan XXIII s n, 08028 Barcelona, Spain
    Int J Dev Neurosci 27:47-52. 2009
    ..On the other hand, as blood-brain barrier permeability in SAMP8 mice increases with age, blood-brain barrier alterations may contribute to the cerebral pathology observed in this strain...
  36. doi request reprint Evaluation of potential pro-survival pathways regulated by melatonin in a murine senescence model
    Javier Gutierrez-Cuesta
    Unitat de Farmacologia i Farmacognòsia Facultat de Farmàcia, Institut de Biomedicina IBUB, Centros de Investigación Biomédica en Red de Enfermedades Neurodegenerativas, Universitat de Barcelona, Nucli Universitari de Pedralbes, Barcelona, Spain
    J Pineal Res 45:497-505. 2008
    ..Melatonin reduced all these changes. We conclude that melatonin improves pro-survival signals and reduces pro-death signals in age-related impairments of neural processes...
  37. doi request reprint Content and traffic of taurine in hippocampal reactive astrocytes
    Felix Junyent
    Unitat de Farmacologia i Farmacognòsia Facultat de Farmàcia, Institut de Biomedicina IBUB, Centros de Investigación Biomédica en Red de Enfermedades Neurodegenerativas CIBERNED, Universitat de Barcelona, Spain
    Hippocampus 21:185-97. 2011
    ..All data obtained indicate that astrocytes could play a key role in taurine level changes induced by neuronal damage. More studies are, therefore, needed to clarify the role taurine has in relation to neuronal death and repair...
  38. doi request reprint Prosurvival role of JAK/STAT and Akt signaling pathways in MPP+-induced apoptosis in neurons
    Felix Junyent
    Institut de Biomedicina IBUB, Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas CIBERNED, Facultat de Farmacia, Universitat de Barcelona, Barcelona, Spain
    Neurochem Int 57:774-82. 2010
    ..Meanwhile Akt activation, using a PTEN inhibitor, did not play a prominent role in neuroprotection; loss of STAT3 could be a signal pathway involved in neuroprotection against the Parkinsonian neurotoxin MPP(+)...
  39. ncbi request reprint Endogenous brain-derived neurotrophic factor protects dopaminergic nigral neurons against transneuronal degeneration induced by striatal excitotoxic injury
    Anna M Canudas
    Departament de Biologia Cel lular i Anatomia Patològica, Facultat de Medicina, Universitat de Barcelona, IDIBAPS, Casanova 143, E 08036 Barcelona, Spain
    Brain Res Mol Brain Res 134:147-54. 2005
    ..Thus, our results show that BDNF exerts an autocrine/paracrine protective effect selectively on dopaminergic neurons against the loss of trophic support from the target striatum...
  40. doi request reprint Novel huprine derivatives with inhibitory activity toward β-amyloid aggregation and formation as disease-modifying anti-Alzheimer drug candidates
    Elisabet Viayna
    Laboratori de Química Farmacèutica Unitat Associada al CSIC, Facultat de Farmacia, and Institut de Biomedicina IBUB, Universitat de Barcelona, Av Diagonal 643, 08028, Barcelona, Spain
    ChemMedChem 5:1855-70. 2010
    ....
  41. doi request reprint Early amyloid accumulation in the hippocampus of SAMP8 mice
    Jaume del Valle
    Departament de Fisiologia, Facultat de Farmacia, Universitat de Barcelona, Barcelona, Spain
    J Alzheimers Dis 19:1303-15. 2010
    ..The demonstration that SAMP8 mice present with amyloid deposits in their hippocampus makes this animal model a useful tool to understand the mechanisms involved in Abeta deposition in AD...
  42. doi request reprint Neuronal apoptosis in the striatum of rats treated with 3-nitropropionic acid is not triggered by cell-cycle re-entry
    Joaquim Duran-Vilaregut
    Departament de Fisiologia, Facultat de Farmacia, Universitat de Barcelona, Av Joan XXIII s n, E 08028 Barcelona, Spain
    Neurotoxicology 32:734-41. 2011
    ....
  43. ncbi request reprint Inhibition of CDKs: a strategy for preventing kainic acid-induced apoptosis in neurons
    E Verdaguer
    Unitat de Farmacologia i Farmacognosia, Facultat de Farmacia, Universitat de Barcelona, Barcelona, Spain
    Ann N Y Acad Sci 1010:671-4. 2003
    ..We concluded that CDK activation is involved, at least, in part, in the pro-apoptotic effects of kainic acid...
  44. doi request reprint Study of the pathways involved in apoptosis induced by PI3K inhibition in cerebellar granule neurons
    Aurelio Vazquez De la Torre
    Unitat de Farmacologia i Farmacognosia, Facultat de Farmacia, Centros de Investigación Biomédica en Red Enfermedades Neurodegenerativas CIBERNED, Institut de Biomedicina, Universitat de Barcelona, Nucli Universitari de Pedralbes, 08028 Barcelona, Spain
    Neurochem Int 59:159-67. 2011
    ....
  45. ncbi request reprint Neuroprotective effects of caffeine against complex I inhibition-induced apoptosis are mediated by inhibition of the Atm/p53/E2F-1 path in cerebellar granule neurons
    Daniel Alvira
    Unitat de Farmacologia i Farmacognosia, Facultat de Farmacia, Universitat de Barcelona, Nucli Universitari de Pedralbes, Barcelona, Spain
    J Neurosci Res 85:3079-88. 2007
    ....
  46. doi request reprint Characterization of amyloid-β granules in the hippocampus of SAMP8 mice
    Gemma Manich
    Departament de Fisiologia, Facultat de Farmacia, Universitat de Barcelona, Barcelona, Spain
    J Alzheimers Dis 25:535-46. 2011
    ..As the components identified in Aβ granules are characteristic of the aggregates present in some neurodegenerative diseases, the SAMP8 model seems to be appropriate for the study of the processes involved in these pathologies...
  47. doi request reprint Potential mechanisms involved in the prevention of neurodegenerative diseases by lithium
    Antoni Camins
    Unitat de Farmacologia i Farmacognòsia Facultat de Farmàcia, Centros de Investigación Biomédica en Red de Enfermedades Neurodegenerativas CIBERNED, Institut de Biomedicina IBUB Universitat de Barcelona, Barcelona, Spain
    CNS Neurosci Ther 15:333-44. 2009
    ....
  48. doi request reprint Gene expression profile in JNK3 null mice: a novel specific activation of the PI3K/AKT pathway
    Felix Junyent
    Unitat de Farmacologia i Farmacognosia, Facultat de Farmacia, Institut de Biomedicina IBUB, Centros de Investigación Biomédica en Red de Enfermedades Neurodegenerativas CIBERNED, Universitat de Barcelona, Barcelona, Spain
    J Neurochem 117:244-52. 2011
    ..Therefore, our results indicate that the activation of PI3K/AKT pathway in hippocampus because of the increase in pik3cb transcription and that this mechanism is specifically related to the lack of Jnk3...
  49. doi request reprint Sirtuin activators: designing molecules to extend life span
    Antoni Camins
    Unitat de Farmacologia i Farmacognòsia Facultat de Farmàcia, Institut de Biomedicina IBUB, Centros de Investigación Biomédica en Red de Enfermedades Neurodegenerativas CIBERNED, Universitat de Barcelona, Nucli Universitari de Pedralbes, 08028 Barcelona, Spain
    Biochim Biophys Acta 1799:740-9. 2010
    ..This review summarises current knowledge about the biological functions of SIRT1 in aging and aging-associated diseases and discusses its potential as a pharmacological target...
  50. doi request reprint Tau hyperphosphorylation and axonal damage induced by N,N-diethyldithiocarbamate (DEDTC) treatment along late postnatal development is followed by a rescue during adulthood
    Juana Utrera
    Departament de Biologia Cellular, Facultat Biologia, Universitat Barcelona, Barcelona, Spain
    J Neurosci Res 88:1083-93. 2010
    ..All these data support the idea that the axonal damage induced by DEDTC treatment along postnatal development is followed by an axonal rescue during adulthood...
  51. ncbi request reprint Inhibition of ataxia telangiectasia-p53-E2F-1 pathway in neurons as a target for the prevention of neuronal apoptosis
    Antoni Camins
    Unitat de Farmacologia i Farmacognosia, Facultat de Farmacia, Universitat de Barcelona, Nucli Universitari de Pedralbes, 08028, Barcelona, Spain
    Curr Drug Metab 8:709-15. 2007
    ..Finally, we put forward drugs that are now being studied experimentally, such as p53 inhibitors, ATM inhibitors and cyclin-dependent kinase (CDKs) inhibitors, for the treatment of neurodegenerative diseases...
  52. ncbi request reprint p21(WAF1/Cip1) is not involved in kainic acid-induced apoptosis in murine cerebellar granule cells
    Ester Verdaguer
    Unitat de Farmacologia i Farmacognosia, Facultat de Farmacia, Universitat de Barcelona, Nucli Universitari de Pedralbes, E 08028 Barcelona, Spain
    Brain Res 1030:297-302. 2004
    ..Data suggest that p21(WAF/Cip) was unable to modulate KA-induced apoptosis in murine CGNs...
  53. doi request reprint GSK-3 beta inhibition and prevention of mitochondrial apoptosis inducing factor release are not involved in the antioxidant properties of SB-415286
    Marc Yeste-Velasco
    Unitat de Farmacologia i Farmacognòsia and Institut de Biomedicina IBUB, Facultat de Farmacia, Universitat de Barcelona, Nucli Universitari de Pedralbes, 08028 Barcelona, Spain
    Eur J Pharmacol 588:239-43. 2008
    ..However, these antioxidant properties are independent of GSK-3 beta inhibition and prevention of mitochondrial AIF release...
  54. doi request reprint Tau hyperphosphorylation and increased BACE1 and RAGE levels in the cortex of PPARβ/δ-null mice
    Emma Barroso
    Unitat de Farmacologia, Department de Farmacologia i Química Terapèutica, Facultat de Farmacia, Universitat de Barcelona, Institut de Biomedicina de la UB, IBUB, Spain
    Biochim Biophys Acta 1832:1241-8. 2013
    ..Collectively, our findings indicate that PPARβ/δ deficiency results in cognitive impairment associated with enhanced inflammation, astrogliosis and tau hyperphosphorylation in the cortex...
  55. doi request reprint Dysfunction of astrocytes in senescence-accelerated mice SAMP8 reduces their neuroprotective capacity
    Silvia García-Matas
    Department of Pharmacology and Toxicology, Institut d Investigacions Biomediques de Barcelona, CSIC IDIBAPS, Barcelona, Spain
    Aging Cell 7:630-40. 2008
    ..In addition, our study supports the contention that astrocytes play a key role in neurodegeneration during the aging process...
  56. doi request reprint Blood-brain barrier disruption in the striatum of rats treated with 3-nitropropionic acid
    Joaquim Duran-Vilaregut
    Departament de Fisiologia, Facultat de Farmacia, Universitat de Barcelona, Av Joan XXIII s n, 08028 Barcelona, Spain
    Neurotoxicology 30:136-43. 2009
    ..We conclude that the BBB is severely affected in the 3-NPA rat model of HD and that disruption of this barrier is a crucial event during the development of this disease...
  57. ncbi request reprint Carnosine prevents methamphetamine-induced gliosis but not dopamine terminal loss in rats
    David Pubill
    Unitat de Farmacological i Farmacognòsia, Facultat de Farmacia, Universitat de Barcelona, Avgda Diagonal 643, 08028 Barcelona, Spain
    Eur J Pharmacol 448:165-8. 2002
    ..Therefore, carnosine inhibits only some of the consequences of methamphetamine neurotoxicity, where reactive oxygen species play an important role...
  58. doi request reprint An overview of investigational antiapoptotic drugs with potential application for the treatment of neurodegenerative disorders
    Antoni Camins
    Institut de Biomedicina IBUB, Facultat de Farmacia, Universitat de Barcelona, Barcelona, Spain
    Expert Opin Investig Drugs 19:587-604. 2010
    ..Given this new social scenario, there is a need to identify therapeutic strategies to delay the advance of these pathologies, for which no effective treatment is currently available...
  59. doi request reprint DNA low-density array analysis of colchicine neurotoxicity in rat cerebellar granular neurons
    Marc Yeste-Velasco
    Facultat de Farmacia, Universitat de Barcelona, Nucli Universitari de Pedralbes, 08028 Barcelona, Spain
    Neurotoxicology 29:309-17. 2008
    ..Present data may help to a better understanding of the molecular mechanisms involved in cytoskeletal degradation-induced apoptosis in neurons...
  60. doi request reprint Resveratrol inhibits proliferation and promotes apoptosis of neuroblastoma cells: role of sirtuin 1
    Javier G Pizarro
    Institut de Biomedicina IBUB, Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas CIBERNED, Facultat de Farmacia, Universitat de Barcelona, Barcelona, Spain
    Neurochem Res 36:187-94. 2011
    ..Our results show that a decrease in SIRT1 content, caused by exposure to resveratrol, does not appear to be involved in cell-cycle arrest or activation of apoptosis...
  61. doi request reprint Anti-aging properties of melatonin in an in vitro murine senescence model: involvement of the sirtuin 1 pathway
    M Tajes
    Unitat de Farmacologia i Farmacognòsia Facultat de Farmàcia, Institut de Biomedicina IBUB, Centros de Investigación Biomédica en Red de Enfermedades Neurodegenerativas CIBERNED, Universitat de Barcelona, Nucli Universitari de Pedralbes, Barcelona, Spain
    J Pineal Res 47:228-37. 2009
    ..Globally, these results add weight to the findings of previous reports, indicating a new role for melatonin in improving cell function gated to an increased neuroprotective role for the sirtuin 1 pathway...
  62. ncbi request reprint Resveratrol and neurodegenerative diseases: activation of SIRT1 as the potential pathway towards neuroprotection
    Merce Pallas
    Facultat de Farmacia, Institut de Biomedicina IBUB, Centro de Investigación de Biomedicina en Red de Enfermedades Neurodegenerativas, Universitat de Barcelona, Nucli Universitari de Pedralbes, Barcelona, Spain
    Curr Neurovasc Res 6:70-81. 2009
    ..In addition, we discuss the possibility of using resveratrol in the treatment of neurodegenerative diseases...
  63. doi request reprint The p38(MAPK) signaling pathway regulates neuronal apoptosis through the phosphorylation of the retinoblastoma protein
    Marc Yeste-Velasco
    Unitat de Farmacologia i Farmacognosia, Facultat de Farmacia, Institut de Biomedicina IBUB, Centros de Investigación Biomédica en Red de Enfermedades Neurodegenerativas CIBERNED, Universitat de Barcelona, Avinguda Diagonal 643, 08028 Barcelona, Spain
    Neurochem Int 54:99-105. 2009
    ..In conclusion, these results suggest that p38MAPK converged with the cell cycle in S/K deprivation-induced apoptosis through pRb phosphorylation...
  64. doi request reprint Activation of Akt by lithium: pro-survival pathways in aging
    Marta Tajes
    Unitat de Farmacologia i Farmacognòsia Facultat de Farmàcia, Institut de Biomedicina, Centros de Investigación Biomédica en Red de Enfermedades Neurodegenerativas CIBERNED, Universitat de Barcelona, Nucli Universitari de Pedralbes, Barcelona, Spain
    Mech Ageing Dev 130:253-61. 2009
    ..These results demonstrate the effectiveness of lithium in preventing age-related neural loss and the potential therapeutic applications of lithium in treatment/prevention of neurological disease...
  65. ncbi request reprint From aging to Alzheimer's disease: unveiling "the switch" with the senescence-accelerated mouse model (SAMP8)
    Merce Pallas
    Unitat de Farmacologia, Facultat de Farmàcia Institut de Biomedicina Universitat de Barcelona IBUB, Nucli Universitari de Pedralbes, Barcelona, Spain
    J Alzheimers Dis 15:615-24. 2008
    ..Here, the neurochemical, neuropathological, and behavioral alterations, characterized in SAMP8 mice are critically reviewed and discussed in relation to the potential use of this mouse model in the study of AD pathogenesis...
  66. doi request reprint Long-term exercise modulates hippocampal gene expression in senescent female mice
    María Jesús Alvarez-López
    Instituto de Investigaciones Biomédicas August Pi i Sunyer IDIBAPS, Barcelona, Spain
    J Alzheimers Dis 33:1177-90. 2013
    ..As a whole, our study suggests that exercise training during adulthood may prevent or delay gene expression alterations and processes associated with hippocampal aging in at-risk subjects...
  67. doi request reprint Neurons from senescence-accelerated SAMP8 mice are protected against frailty by the sirtuin 1 promoting agents melatonin and resveratrol
    Rosa Cristofol
    Institut d Investigacions Biomediques de Barcelona, CSIC, IDIBAPS, Barcelona, Spain
    J Pineal Res 52:271-81. 2012
    ..This supports the therapeutic use of sirtuin 1-enhancing agents against age-related nerve cell dysfunction and brain frailty...
  68. doi request reprint Neuroprotective and anti-ageing role of leptin
    Jaume Folch
    Unitat de Farmacologia i Farmacognosia, Institut de Biomedicina, Centros de Investigación Biomédica en Red Enfermedades Neurodegenerativas, Universitat de Barcelona, Nucli Universitari de Pedralbes, 08028 Barcelona, Spain
    J Mol Endocrinol 49:R149-56. 2012
    ..Moreover, Lep might promote the activation of a cognitive process that may retard or even partially reverse selected aspects of Alzheimer's disease or ageing memory loss...
  69. ncbi request reprint The role of CDK5/P25 formation/inhibition in neurodegeneration
    Antoni Camins
    Unitat de Farmacologia i Farmacognosia, Facultat de Farmacia, Universitat de Barcelona, E 08028 Barcelona, Spain
    Drug News Perspect 19:453-60. 2006
    ..Furthermore, the dual inhibitory effect of some of these drugs on cdk5 and GSK3beta could be beneficial...
  70. doi request reprint A new method for determining blood-brain barrier integrity based on intracardiac perfusion of an Evans Blue-Hoechst cocktail
    Jaume del Valle
    Departament de Fisiologia, Facultat de Farmacia, Universitat de Barcelona, Av Joan XXIII s n, Barcelona, Spain
    J Neurosci Methods 174:42-9. 2008
    ..Thus, immunohistochemistry has been used here to determine the nature of intense EB fluorescent cells that appear in the perilesional rim, which were identified here as neuronal cells...
  71. doi request reprint Cerebral amyloid angiopathy, blood-brain barrier disruption and amyloid accumulation in SAMP8 mice
    Jaume del Valle
    Departament de Fisiologia, Facultat de Farmacia, Barcelona, Spain
    Neurodegener Dis 8:421-9. 2011
    ..Finally, we can conclude that vascular amyloid deposition seems to induce BBB alterations, but BBB disruption may also be due to other factors...
  72. ncbi request reprint Calpains as a target for therapy of neurodegenerative diseases: putative role of lithium
    Antoni Camins
    Institut de Biomedicina, Centros de Investigación Biomédica en Red de Enfermedades Neurodegenerativas, Universitat de Barcelona Nucli Universitari de Pedralbes, Barcelona, Spain
    Curr Drug Metab 10:433-47. 2009
    ....
  73. ncbi request reprint Evaluation of the neuronal apoptotic pathways involved in cytoskeletal disruption-induced apoptosis
    Elvira G Jorda
    Unitat de Farmacologia i Farmacognosia, Facultat de Farmacia, Universitat de Barcelona, Nucli Universitari de Pedralbes, E 08028 Barcelona, Spain
    Biochem Pharmacol 70:470-80. 2005
    ..The present data indicate the potential therapeutic value of drugs that prevent the formation of p25 for the treatment of neurodegenerative disorders...
  74. doi request reprint Aging biology: a new frontier for drug discovery
    Ester Verdaguer
    Unitat de Farmacologia i Farmacognòsia Facultat de Farmàcia, Institut de Biomedicina, Centros de Investigación Biomédica en Red de Enfermedades Neurodegenerativas, Universitat de Barcelona, Nucli Universitari de Pedralbes, Spain
    Expert Opin Drug Discov 7:217-29. 2012
    ..Antiaging molecules and appropriate animal models need to be developed to prevent and or delay alterations that occur during aging and are manifested as age-associated illnesses...
  75. doi request reprint Synthesis, uptake and release of taurine in astrocytes treated with 8-Br-cAMP
    Felix Junyent
    Unitat de Farmacologia i Farmacognòsia Facultat de Farmàcia, Institut de Biomedicina, Centros de Investigación Biomédica en Red de Enfermedades Neurodegenerativas, Universitat de Barcelona, Avda Diagnol 643, 08028 Barcelona, Spain
    Neurosci Lett 467:199-202. 2009
    ..The data indicate that taurine synthesis and traffic kinetics vary according to the differentiation state of the astrocytes. Thus, our results highlight the importance of astrocytes in modulating taurine levels in the brain...
  76. doi request reprint The antiproliferative activity of melatonin in B65 rat dopaminergic neuroblastoma cells is related to the downregulation of cell cycle-related genes
    Javier G Pizarro
    Unitat de Farmacologia i Farmacognosia, Facultat de Farmacia, Universitat de Barcelona, Nucli Universitari de Pedralbes, Barcelona, Spain
    J Pineal Res 45:8-16. 2008
    ....
  77. ncbi request reprint Hyperphosphorylation of microtubule-associated protein tau in senescence-accelerated mouse (SAM)
    Anna M Canudas
    Unitat de Farmacologia i Farmacognosia, Facultat de Farmacia, Universitat de Barcelona, Nucli Universitari de Pedralbes, E 08028 Barcelona, Spain
    Mech Ageing Dev 126:1300-4. 2005
    ..In conclusion, tau hyperphosphorylation occurs in SAMP-8 (early senescent) mice, indicating a link between aging and tau modifications in this murine model...
  78. ncbi request reprint Chronic administration of melatonin reduces cerebral injury biomarkers in SAMP8
    Javier Gutierrez-Cuesta
    Unitat de Farmacologia i Farmacognosia, Facultat de Farmàcia and Institut de Biomedicina, Universitat de Barcelona, Nucli Universitari de Pedralbes, Barcelona, Spain
    J Pineal Res 42:394-402. 2007
    ..Moreover, these data suggest that the cdk5/GSKbeta signaling cascade has a potential role as a target for neurodegenerative diseases related to aging...
  79. ncbi request reprint Increased permeability of blood-brain barrier on the hippocampus of a murine model of senescence
    Carme Pelegri
    Departament de Fisiologia, Facultat de Farmacia, Universitat de Barcelona, Av Joan XXIII s n, 08028 Barcelona, Spain
    Mech Ageing Dev 128:522-8. 2007
    ..We have found significantly higher levels of IgG extravasation in the hippocampus of 12-month-old SAMP8 mice compared to SAMR1 mice, indicating an increased permeability of BBB in aged senescence-accelerated mice...
  80. ncbi request reprint Dendritic spine abnormalities in hippocampal CA1 pyramidal neurons underlying memory deficits in the SAMP8 mouse model of Alzheimer's disease
    Jaume del Valle
    Facultat de Farmacia, Unitat de Farmacologia i Farmacognosia, Institut de Biomedicina IBUB, Universitat de Barcelona, Nucli Universitari de Pedralbes, Barcelona, Spain
    J Alzheimers Dis 32:233-40. 2012
    ..Thus, we conclude that together with other studies that describe several alterations at similar ages, SAMP8 mice are a very suitable model for studying AD...
  81. ncbi request reprint PGC-1beta down-regulation is associated with reduced ERRalpha activity and MCAD expression in skeletal muscle of senescence-accelerated mice
    Ricardo Rodríguez-Calvo
    Unitat de Farmacologia, Facultat de Farmacia, Diagonal 643, E 08028 Barcelona, Spain
    J Gerontol A Biol Sci Med Sci 61:773-80. 2006
    ..These findings indicate that the age-mediated decrease in PGC-1beta expression in SAM-P8 skeletal muscle affects the expression of genes involved in mitochondrial fatty acid oxidation...
  82. ncbi request reprint Activation of the calpain/cdk5/p25 pathway in the girus cinguli in Parkinson's disease
    Daniel Alvira
    Unitat de Farmacologia i Farmacognosia, Facultat de Farmacia, Universitat de Barcelona, Nucli Universitari de Pedralbes, 08028 Barcelona, Spain
    Parkinsonism Relat Disord 14:309-13. 2008
    ..Our results implicate the cdk5/p25 pathway and re-entry into the cell cycle in the process of neuronal loss in patients with PD...
  83. ncbi request reprint Inhibition of cell cycle pathway by flavopiridol promotes survival of cerebellar granule cells after an excitotoxic treatment
    Ester Verdaguer
    Unitat de Farmacologia i Farmacognosia, Facultat de Farmacia, Universitat de Barcelona, Nucli Universitari de Pedralbes, Barcelona, Spain
    J Pharmacol Exp Ther 308:609-16. 2004
    ..Flavopiridol might thus be used as a preventive agent against neurodegenerative diseases associated with cell cycle activation...
  84. ncbi request reprint Hypertriglyceridemia and hepatic steatosis in senescence-accelerated mouse associate to changes in lipid-related gene expression
    Laia Vilà
    Department of Pharmacology and Therapeutic Chemistry, University of Barcelona, Barcelona, Spain
    J Gerontol A Biol Sci Med Sci 62:1219-27. 2007
    ..Triglyceride accretion and a deficit in hepatic fatty acid oxidation, features of the aging process in mammals, associate to a deficit in hepatic FXR activity in the SAM-P8 mice...
  85. doi request reprint Synthesis and pharmacological evaluation of several ring-contracted amantadine analogs
    Pelayo Camps
    Laboratori de Química Farmacèutica Unitat Associada al CSIC, Facultat de Farmacia, and Institute of Biomedicine IBUB, Universitat de Barcelona, Av Diagonal, 643, Barcelona E 08028, Spain
    Bioorg Med Chem 16:9925-36. 2008
    ..A rimantadine analogue displayed significant trypanocidal activity. Moreover, to further characterize the pharmacology of these compounds, their effects on dopamine uptake were also assessed...
  86. doi request reprint Novel donepezil-based inhibitors of acetyl- and butyrylcholinesterase and acetylcholinesterase-induced beta-amyloid aggregation
    Pelayo Camps
    Laboratori de Química Farmacèutica Unitat Associada al CSIC, Facultat de Farmacia, Barcelona, Spain
    J Med Chem 51:3588-98. 2008
    ..Moreover, six out of the eight hybrids of the series, particularly those bearing an indane moiety, exhibit a significant A beta antiaggregating activity, which makes them promising anti-Alzheimer drug candidates...
  87. ncbi request reprint 3-Nitropropionic acid activates calpain/cdk5 pathway in rat striatum
    Natalia Crespo-Biel
    Unitat de Farmacologia i Farmacognosia, Facultat de Farmacia, Universitat de Barcelona, Nucli Universitari de Pedralbes, E 08028 Barcelona, Spain
    Neurosci Lett 421:77-81. 2007
    ..We suggest that calpain/cdk5 activation could also be a common pathway activated in other neurodegenerative diseases, which is liable to be targeted...
  88. ncbi request reprint Free radical production induced by methamphetamine in rat striatal synaptosomes
    David Pubill
    Unitat de Farmacologia i Farmacognosia, Facultat de Farmacia, Nucli Universitari de Pedralbes, Universitat de Barcelona, 08028 Barcelona, Spain
    Toxicol Appl Pharmacol 204:57-68. 2005
    ..This would lead to DAT inhibition and NOS and PKC activation, initiating oxidation of cytosolic DA...
  89. doi request reprint Neurophysiological and epigenetic effects of physical exercise on the aging process
    Perla Kaliman
    Instituto de Investigaciones Biomedicas August Pi i Sunyer, Barcelona, Spain
    Ageing Res Rev 10:475-86. 2011
    ....
  90. doi request reprint Retinol-binding protein 4 and peroxisome proliferator-activated receptor-γ in steatotic liver transplantation
    Arani Casillas-Ramirez
    Institut d Investigacions Biomediques August Pi i Sunyer, Barcelona, Spain
    J Pharmacol Exp Ther 338:143-53. 2011
    ..RBP4 treatment and PC, through RBP4 induction, reduced PPARγ levels in steatotic liver grafts, thus protecting them from the PPARγ detrimental effects...
  91. ncbi request reprint Activation of ERK and Akt signaling in focal cerebral ischemia: modulation by TGF-alpha and involvement of NMDA receptor
    Bibiana Friguls
    Departament de Farmacologia i Toxicologia, Institut d Investigacions Biomediques de Barcelona, CSIC IDIBAPS, Facultat de Farmacia, Universitat de Barcelona, Barcelona, Spain
    Neurobiol Dis 11:443-56. 2002
    ..This study illustrates that neuroprotection results from a fine balance between death and survival signaling pathways...